Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HSPG2	3339	broad.mit.edu	37	1	22207993	22207993	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:22207993C>T	uc001bfj.2	-	14	1697	c.1657G>A	c.(1657-1659)GTG>ATG	p.V553M	HSPG2_uc009vqd.2_Missense_Mutation_p.V554M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	553	Laminin IV type A 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GTCACATTCACACCTGTGGGT	0.617			NA											33	94					0	0	0.004289	0	0
CLCA4	22802	broad.mit.edu	37	1	87031633	87031633	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:87031633C>T	uc009wcs.2	+	6	928	c.884C>T	c.(883-885)CCT>CTT	p.P295L	CLCA4_uc009wct.2_Missense_Mutation_p.P58L|CLCA4_uc009wcu.2_Missense_Mutation_p.P115L	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	295						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CCTCCTCCACCTGTCTTCTCA	0.403			NA											19	46					0	0	0.00278	0	0
DPH5	51611	broad.mit.edu	37	1	101460684	101460684	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:101460684G>T	uc001dts.2	-	6	659	c.512C>A	c.(511-513)TCT>TAT	p.S171Y	DPH5_uc001dtr.2_Missense_Mutation_p.S171Y|DPH5_uc001dtq.2_RNA|DPH5_uc001dtt.2_Missense_Mutation_p.S171Y|DPH5_uc001dtu.2_RNA|DPH5_uc001dtv.2_RNA|DPH5_uc001dtw.2_RNA|DPH5_uc001dtx.2_Missense_Mutation_p.S171Y|DPH5_uc001dty.2_Missense_Mutation_p.S50Y|DPH5_uc001dtz.2_RNA	NM_015958	NP_057042	Q9H2P9	DPH5_HUMAN	diphthine synthase isoform a	171					peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity				0		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)		ATTTTCCAAAGACTGCTCCTT	0.294			NA											5	19					0.00116845	0.00127686	0.001168	1	0
POLR3C	10623	broad.mit.edu	37	1	145608468	145608468	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:145608468G>A	uc001eoh.2	-	3	500	c.339C>T	c.(337-339)AAC>AAT	p.N113N	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Silent_p.N126N|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Silent_p.N113N	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	113					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			TCAGTTTGCCGTTCAACAGAA	0.468			NA											4	125					0	0	0.000602	0	0
FLG	2312	broad.mit.edu	37	1	152279739	152279739	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:152279739G>A	uc001ezu.1	-	3	7659	c.7623C>T	c.(7621-7623)GCC>GCT	p.A2541A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2541	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAGCTGTCGGCCCGAGAGG	0.582			NA							Ichthyosis				8	392					0	0	0.008291	0	0
FLG2	388698	broad.mit.edu	37	1	152328035	152328035	+	Missense_Mutation	SNP	A	A	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:152328035A>C	uc001ezw.3	-	3	2300	c.2227T>G	c.(2227-2229)TCT>GCT	p.S743A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	743	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAAAGCCAGAGGACTGACCT	0.507			NA											9	547					0	0	0.006214	0	0
FLG2	388698	broad.mit.edu	37	1	152328059	152328059	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:152328059G>A	uc001ezw.3	-	3	2276	c.2203C>T	c.(2203-2205)CAT>TAT	p.H735Y	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	735	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGATCCATGTTGGCCAAAG	0.498			NA											7	530					0	0	0.004482	0	0
ADAR	103	broad.mit.edu	37	1	154561033	154561033	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:154561033T>C	uc001ffh.2	-	10	3079	c.2879A>G	c.(2878-2880)TAT>TGT	p.Y960C	ADAR_uc001ffj.2_Missense_Mutation_p.Y915C|ADAR_uc001ffi.2_Missense_Mutation_p.Y934C|ADAR_uc001ffk.2_Missense_Mutation_p.Y665C	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	960	A to I editase.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		AGACCTGATATACAGATGGAA	0.448			NA											30	108					0	0	0.013726	0	0
C1orf104	284618	broad.mit.edu	37	1	155291133	155291133	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:155291133C>T	uc001fki.2	-	2	424	c.147G>A	c.(145-147)CAG>CAA	p.Q49Q	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_Intron|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	49											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GTCCCTTCCTCTGGGAGTAAG	0.647			NA											4	16					0	0	0.009096	0	0
TNN	63923	broad.mit.edu	37	1	175066576	175066576	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:175066576G>T	uc001gkl.1	+	8	1725	c.1612G>T	c.(1612-1614)GTG>TTG	p.V538L	TNN_uc010pmx.1_Intron	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	538	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCAAACCTGGTGACTGACCG	0.502			NA											21	37					1.10513e-12	1.54137e-12	0.014323	1	0
C1orf26	54823	broad.mit.edu	37	1	185149536	185149536	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:185149536C>T	uc001grg.3	+	6	1094	c.980C>T	c.(979-981)CCA>CTA	p.P327L	C1orf26_uc001grh.3_Missense_Mutation_p.P327L	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	327											0						TTTGAAGCACCATGTTGTTCC	0.249			NA											7	28					0	0	0.001984	0	0
HMCN1	83872	broad.mit.edu	37	1	186106702	186106702	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:186106702G>A	uc001grq.1	+	88	13884	c.13655G>A	c.(13654-13656)AGG>AAG	p.R4552K	HMCN1_uc001grs.1_Missense_Mutation_p.R121K	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4552	TSP type-1 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATCCAAAAGAGGAGTCGTCTG	0.483			NA											6	34					0	0	0.001168	0	0
PRSS38	339501	broad.mit.edu	37	1	228005073	228005073	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:228005073C>T	uc001hrh.2	+	3	475	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	159	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						GCTGAAGACCCGCATTGTGTT	0.567			NA											14	71					0	0	0.003163	0	0
OR2L8	391190	broad.mit.edu	37	1	248112889	248112889	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:248112889C>A	uc001idt.1	+	1	730	c.730C>A	c.(730-732)CTC>ATC	p.L244I	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CAGCACCCACCTCACTGTAGT	0.458			NA											30	82					1.96642e-18	2.93578e-18	0.006999	1	0
SFMBT2	57713	broad.mit.edu	37	10	7230597	7230597	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr10:7230597C>T	uc009xio.1	-	16	1888	c.1797G>A	c.(1795-1797)ACG>ACA	p.T599T	SFMBT2_uc001ijn.1_Silent_p.T599T|SFMBT2_uc010qay.1_Silent_p.T434T	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	599					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TGGCCTTCAGCGTCTCTTCCT	0.443			NA											11	31					0	0	0.008291	0	0
CUBN	8029	broad.mit.edu	37	10	17087120	17087120	+	Nonsense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr10:17087120G>T	uc001ioo.2	-	25	3610	c.3558C>A	c.(3556-3558)TAC>TAA	p.Y1186*		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1186	CUB 7.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGAGCTGTGGTAATAGGGCA	0.488			NA											16	49					6.49762e-13	9.12249e-13	0.006122	1	0
PCDH15	65217	broad.mit.edu	37	10	55755437	55755437	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr10:55755437G>C	uc001jju.1	-	21	3235	c.2840C>G	c.(2839-2841)ACA>AGA	p.T947R	PCDH15_uc010qhq.1_Missense_Mutation_p.T952R|PCDH15_uc010qhr.1_Missense_Mutation_p.T947R|PCDH15_uc010qhs.1_Missense_Mutation_p.T959R|PCDH15_uc010qht.1_Missense_Mutation_p.T954R|PCDH15_uc010qhu.1_Missense_Mutation_p.T947R|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.T947R|PCDH15_uc010qhw.1_Missense_Mutation_p.T910R|PCDH15_uc010qhx.1_Missense_Mutation_p.T876R|PCDH15_uc010qhy.1_Missense_Mutation_p.T952R|PCDH15_uc010qhz.1_Missense_Mutation_p.T947R|PCDH15_uc010qia.1_Missense_Mutation_p.T925R|PCDH15_uc010qib.1_Missense_Mutation_p.T925R|PCDH15_uc001jjw.2_Missense_Mutation_p.T947R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	947	Extracellular (Potential).|Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AGCATAAACTGTTGTGATAGG	0.388			NA								HNSCC(58;0.16)			19	69					0	0	0.00278	0	0
TLL2	7093	broad.mit.edu	37	10	98145954	98145954	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr10:98145954A>T	uc001kml.1	-	15	2097	c.1871T>A	c.(1870-1872)ATT>AAT	p.I624N		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	624	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CAGCTTGGTAATGAAACCGCC	0.552			NA											24	86					0	0	0.004656	0	0
MKI67	4288	broad.mit.edu	37	10	129911758	129911758	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr10:129911758C>A	uc001lke.2	-	8	1784	c.1589G>T	c.(1588-1590)GGA>GTA	p.G530V	MKI67_uc001lkf.2_Missense_Mutation_p.G170V|MKI67_uc009yav.1_Missense_Mutation_p.G105V|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	530					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGGGCTTCTCCCCTTTTGAG	0.473			NA											36	76					1.04594e-18	1.58385e-18	0.00623	1	0
OR56A3	390083	broad.mit.edu	37	11	5969311	5969311	+	Nonsense_Mutation	SNP	T	T	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:5969311T>A	uc010qzt.1	+	1	735	c.735T>A	c.(733-735)TGT>TGA	p.C245*		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAAGCACATGTGGCTCCCACT	0.517			NA											58	151					0	0	0.01441	0	0
TPP1	1200	broad.mit.edu	37	11	6637975	6637975	+	Missense_Mutation	SNP	C	C	G	rs141920079		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:6637975C>G	uc001mel.1	-	7	864	c.803G>C	c.(802-804)CGG>CCG	p.R268P	TPP1_uc001mek.1_Missense_Mutation_p.R25P	NM_000391	NP_000382	O14773	TPP1_HUMAN	tripeptidyl-peptidase I preproprotein	268					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		AATCCCGGCCCGGCCCCGGCC	0.577			NA											27	138					0	0	0.010818	0	0
MPPED2	744	broad.mit.edu	37	11	30601847	30601848	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:30601847_30601848GC>AA	uc001msr.2	-	1	193_194	c.73_74GC>TT	c.(73-75)GCA>TTA	p.A25L	MPPED2_uc001msq.3_Missense_Mutation_p.A25L|MPPED2_uc009yji.2_5'UTR	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	25					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						GTGCGTGAATGCCTGGGTGGGG	0.436			NA											30	73					0	0	0.004672	0	0
OR5B21	219968	broad.mit.edu	37	11	58275029	58275029	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:58275029C>A	uc010rki.1	-	1	550	c.550G>T	c.(550-552)GCT>TCT	p.A184S		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CATGAGAGAGCCAGGAGTGGG	0.473			NA											10	25					9.05144e-12	1.22223e-11	0.001855	1	0
CNTF	1270	broad.mit.edu	37	11	58391799	58391799	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:58391799G>C	uc001nna.3	+	2	487	c.407G>C	c.(406-408)CGC>CCC	p.R136P	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	136					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AAGATCCCCCGCAATGAGGCT	0.483			NA											13	39					0	0	0.001855	0	0
RARRES3	5920	broad.mit.edu	37	11	63312096	63312096	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:63312096A>G	uc001nxf.3	+	3	190	c.122A>G	c.(121-123)GAG>GGG	p.E41G		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	41					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						ATTGCAGGTGAGTACCCCGGG	0.547			NA											63	205					0	0	0.01441	0	0
MMP7	4316	broad.mit.edu	37	11	102401431	102401431	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:102401431T>C	uc001phb.2	-	1	48	c.1A>G	c.(1-3)ATG>GTG	p.M1V	MMP7_uc009yxd.2_Missense_Mutation_p.M1V|MMP7_uc010rus.1_Missense_Mutation_p.M1V	NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	1					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		GTGAGTCGCATAGCTGCCGTC	0.547			NA											14	31					0	0	0.006122	0	0
ATM	472	broad.mit.edu	37	11	108163369	108163369	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:108163369C>A	uc001pkb.1	+	30	4845	c.4460C>A	c.(4459-4461)TCA>TAA	p.S1487*	ATM_uc009yxr.1_Nonsense_Mutation_p.S1487*|ATM_uc001pke.1_Nonsense_Mutation_p.S139*|ATM_uc001pkf.2_Intron	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1487					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATGGATGTGTCATTACGTAGC	0.363			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			44	100					1.66251e-12	2.28864e-12	0.01441	1	0
KIAA0528	9847	broad.mit.edu	37	12	22631320	22631320	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:22631320T>A	uc001rfq.2	-	15	2057	c.1829A>T	c.(1828-1830)CAC>CTC	p.H610L	KIAA0528_uc010sir.1_Missense_Mutation_p.H425L|KIAA0528_uc010sis.1_Missense_Mutation_p.H610L|KIAA0528_uc010sit.1_Missense_Mutation_p.H612L|KIAA0528_uc010siu.1_Missense_Mutation_p.H610L|KIAA0528_uc001rfr.2_Missense_Mutation_p.H601L|KIAA0528_uc009ziy.1_Missense_Mutation_p.H612L	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	610							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						ATGAGAGATGTGTTGTTCATA	0.368			NA											8	23					0	0	0.004482	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:25398284C>G	uc001rgp.1	-	2	216	c.35G>C	c.(34-36)GGT>GCT	p.G12A	KRAS_uc001rgq.1_Missense_Mutation_p.G12A|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	29					0	0	0.001984	0	0
RAB5B	5869	broad.mit.edu	37	12	56380786	56380786	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:56380786G>T	uc001siv.2	+	2	159	c.42G>T	c.(40-42)CAG>CAT	p.Q14H	RAB5B_uc001siw.2_Missense_Mutation_p.Q14H|RAB5B_uc009zog.2_Missense_Mutation_p.R5M|RAB5B_uc010spz.1_Missense_Mutation_p.Q14H	NM_002868	NP_002859	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	14					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			GGCAACCCCAGGCCAGCAAAA	0.388			NA											15	50					4.63292e-17	6.77365e-17	0.008871	1	0
TMEM5	10329	broad.mit.edu	37	12	64202608	64202608	+	Silent	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:64202608G>T	uc001srq.1	+	6	1172	c.1068G>T	c.(1066-1068)GTG>GTT	p.V356V	TMEM5_uc001srr.1_Silent_p.V253V|TMEM5_uc001srs.1_Silent_p.V96V	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	356	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TGGAAGACGTGATGACAGCTG	0.493			NA											26	77					2.85442e-18	4.23172e-18	0.010818	1	0
TMTC2	160335	broad.mit.edu	37	12	83444707	83444707	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:83444707G>T	uc001szt.2	+	10	2609	c.2177G>T	c.(2176-2178)CGT>CTT	p.R726L	TMTC2_uc010suk.1_Missense_Mutation_p.R481L	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	726	TPR 8.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						GAAGAAGCTCGTCTCATAGAA	0.383			NA											8	26					3.09899e-07	3.64992e-07	0.004482	1	0
POLR3B	55703	broad.mit.edu	37	12	106857254	106857254	+	Splice_Site	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:106857254A>G	uc001tlp.2	+	23	2793	c.2571_splice	c.e23-2	p.T857_splice	POLR3B_uc001tlq.2_Splice_Site_p.T799_splice	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1						innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TCTTAACACCAGCTACAAAGG	0.378			NA											13	38					0	0	0.00499	0	0
TMEM120B	144404	broad.mit.edu	37	12	122190118	122190118	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:122190118C>T	uc001ubc.3	+	5	594	c.450C>T	c.(448-450)GTC>GTT	p.V150V	TMEM120B_uc009zxh.2_Silent_p.V150V	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	150	Helical; (Potential).					integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		GTCGATTTGTCCTTCACTACA	0.607			NA											18	77					0	0	0.007413	0	0
C13orf23	80209	broad.mit.edu	37	13	39587831	39587831	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr13:39587831C>A	uc001uwy.2	-	11	2431	c.1558G>T	c.(1558-1560)GCC>TCC	p.A520S	C13orf23_uc001uwz.2_Missense_Mutation_p.A498S	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	520	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GCTGATGGGGCATAGCACTTG	0.552			NA											12	21					7.03913e-09	8.83015e-09	0.013537	1	0
GPC6	10082	broad.mit.edu	37	13	94482699	94482699	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr13:94482699C>A	uc001vlt.2	+	3	1244	c.612C>A	c.(610-612)CCC>CCA	p.P204P	GPC6_uc010tig.1_Silent_p.P204P|GPC6_uc001vlu.1_Silent_p.P134P	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	204						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAGACGTGCCCCGGAAACTGA	0.512			NA											10	23					0.00621372	0.00665307	0.006214	1	0
OR4M1	441670	broad.mit.edu	37	14	20249076	20249076	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:20249076A>T	uc010tku.1	+	1	595	c.595A>T	c.(595-597)ATG>TTG	p.M199L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGAGTTAGTGATGATCTGTAG	0.478			NA											60	116					0	0	0.01441	0	0
LTB4R	1241	broad.mit.edu	37	14	24785514	24785514	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:24785514C>A	uc001wos.2	+	2	978	c.657C>A	c.(655-657)ACC>ACA	p.T219T	LTB4R_uc010alp.2_Silent_p.T219T|LTB4R_uc001wou.2_Silent_p.T219T	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	219	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		GCCGCCGCACCGGCCGCCTGG	0.716			NA											8	24					0.00829132	0.0087888	0.008291	1	0
NPAS3	64067	broad.mit.edu	37	14	34269442	34269442	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:34269442C>A	uc001wru.2	+	12	1993	c.1929C>A	c.(1927-1929)GCC>GCA	p.A643A	NPAS3_uc001wrs.2_Silent_p.A630A|NPAS3_uc001wrt.2_Silent_p.A611A|NPAS3_uc001wrv.2_Silent_p.A613A	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	643					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CCAACAGTGCCTCGGTGCTCA	0.662			NA											33	34					2.04263e-09	2.59304e-09	0.004289	1	0
LRFN5	145581	broad.mit.edu	37	14	42356845	42356845	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:42356845C>A	uc001wvm.2	+	3	2215	c.1017C>A	c.(1015-1017)AAC>AAA	p.N339K	LRFN5_uc010ana.2_Missense_Mutation_p.N339K	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	339	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGTATGATAACGGAACACTTG	0.448			NA								HNSCC(30;0.082)			47	72					4.02871e-13	5.6939e-13	0.01441	1	0
DDHD1	80821	broad.mit.edu	37	14	53619303	53619303	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:53619303A>T	uc001xai.2	-	1	744	c.514T>A	c.(514-516)TAC>AAC	p.Y172N	DDHD1_uc001xaj.2_Missense_Mutation_p.Y172N|DDHD1_uc001xah.2_Missense_Mutation_p.Y172N	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	172					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					TCCTCCTTGTAGAACCAGCGT	0.677			NA											9	56					0	0	0.013537	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68282537	68282537	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:68282537C>T	uc001xka.2	-	2	283	c.144G>A	c.(142-144)AAG>AAA	p.K48K	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.K48K|ZFYVE26_uc010tta.1_Silent_p.K48K	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	48					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTTCTACCCTCTTTGGGATAT	0.522			NA											4	135					0	0	0.009096	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713810	70713810	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:70713810C>A	uc010ttg.1	-	1	709	c.58G>T	c.(58-60)GCT>TCT	p.A20S		NR_003951				SubName: Full=ADAM21-like protein;												0						GAGTTCTCAGCCTCTTCAAAT	0.433			NA											14	60					1.15088e-07	1.37071e-07	0.004007	1	0
DICER1	23405	broad.mit.edu	37	14	95598876	95598876	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:95598876T>C	uc001ydw.2	-	4	465	c.283A>G	c.(283-285)AGG>GGG	p.R95G	DICER1_uc001ydv.2_Missense_Mutation_p.R85G|DICER1_uc001ydx.2_Missense_Mutation_p.R95G|DICER1_uc001ydz.1_RNA|DICER1_uc001yea.1_RNA|DICER1_uc001yeb.1_RNA	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	95	Helicase ATP-binding.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AACACCGTCCTTTTTCCATTT	0.383			NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				3	128					0	0	0.004672	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416061	105416061	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr14:105416061C>A	uc010axc.1	-	7	5847	c.5727G>T	c.(5725-5727)GTG>GTT	p.V1909V	AHNAK2_uc001ypx.2_Silent_p.V1809V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1909						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGGCATATCCACCTTGGGCA	0.617			NA											12	199					6.31663e-08	7.65214e-08	0.003163	1	0
C15orf2	23742	broad.mit.edu	37	15	24923826	24923826	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr15:24923826G>T	uc001ywo.2	+	1	3286	c.2812G>T	c.(2812-2814)GGC>TGC	p.G938C		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	938					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCCACTGAGTGGCAGCATAAT	0.488			NA											12	69					9.04627e-18	1.33181e-17	0.001855	1	0
RAD51	5888	broad.mit.edu	37	15	41022102	41022102	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr15:41022102G>A	uc001zmi.3	+	9	1125	c.826G>A	c.(826-828)GCA>ACA	p.A276T	RAD51_uc010bbw.2_Intron|RAD51_uc010bbx.2_Missense_Mutation_p.A277T|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.A277T	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	276					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		AGTGGATGGAGCAGCGATGTT	0.438			NA						Homologous_recombination					3	37					0	0	0.004672	0	0
C15orf26	161502	broad.mit.edu	37	15	81429038	81429038	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr15:81429038G>A	uc002bgb.2	+	3	368	c.341G>A	c.(340-342)AGC>AAC	p.S114N	C15orf26_uc010blp.1_Missense_Mutation_p.S89N	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	114											0						TGTGGCCTGAGCGCAGTTCAA	0.423			NA											6	52					0	0	0.001984	0	0
ACAN	176	broad.mit.edu	37	15	89382237	89382237	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr15:89382237C>A	uc010upo.1	+	3	788	c.414C>A	c.(412-414)GGC>GGA	p.G138G	ACAN_uc002bmx.2_Silent_p.G138G|ACAN_uc010upp.1_Silent_p.G138G|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	138					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGATGCATGGCATCGAGGACA	0.607			NA											13	56					1.49906e-05	1.73661e-05	0.00245	1	0
PPL	5493	broad.mit.edu	37	16	4960865	4960865	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:4960865C>T	uc002cyd.1	-	2	238	c.148G>A	c.(148-150)GCC>ACC	p.A50T		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	50	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TGCATCTTGGCCTCTGTGTCC	0.567			NA											9	92					0	0	0.010729	0	0
A2BP1	54715	broad.mit.edu	37	16	7759094	7759094	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:7759094C>A	uc002cys.2	+	15	2020	c.1032C>A	c.(1030-1032)CAC>CAA	p.H344Q	A2BP1_uc002cyt.2_Missense_Mutation_p.H317Q|A2BP1_uc010uxz.1_Missense_Mutation_p.H387Q|A2BP1_uc010uya.1_Missense_Mutation_p.T319K|A2BP1_uc010uyb.1_Missense_Mutation_p.H344Q|A2BP1_uc002cyw.2_Missense_Mutation_p.T383K|A2BP1_uc002cyy.2_Missense_Mutation_p.H365Q|A2BP1_uc002cyx.2_Missense_Mutation_p.H365Q|A2BP1_uc010uyc.1_Missense_Mutation_p.H338Q	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	344					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		CCTACCACCACGCACTTGCTC	0.498			NA											17	78					0.000295444	0.000327927	0.014323	1	0
ABCC6	368	broad.mit.edu	37	16	16255397	16255397	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:16255397G>A	uc002den.3	-	25	3568	c.3531C>T	c.(3529-3531)CTC>CTT	p.L1177L	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1177	Helical; Name=16; (By similarity).|ABC transmembrane type-1 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CATTCCCCAGGAGCTCCACAT	0.607			NA											3	44					0	0	0.004672	0	0
ERN2	10595	broad.mit.edu	37	16	23718096	23718096	+	Missense_Mutation	SNP	G	G	T	rs143761786		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:23718096G>T	uc002dma.3	-	6	779	c.610C>A	c.(610-612)CGC>AGC	p.R204S	ERN2_uc010bxp.2_Missense_Mutation_p.R204S|ERN2_uc010bxq.1_Missense_Mutation_p.R12S	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	156	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		ATGTAGAGGCGGGGGGTGGAG	0.607			NA											15	62					2.52088e-20	3.87265e-20	0.00278	1	0
DOC2A	8448	broad.mit.edu	37	16	30020381	30020381	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:30020381C>G	uc002dvm.2	-	5	563	c.463G>C	c.(463-465)GTG>CTG	p.V155L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Missense_Mutation_p.V155L|DOC2A_uc002dvn.2_Missense_Mutation_p.V155L|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Missense_Mutation_p.V155L|DOC2A_uc002dvp.2_Missense_Mutation_p.V155L|DOC2A_uc002dvq.2_Missense_Mutation_p.V155L	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	155	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						TCATTCCACACGGGATTCAGT	0.567			NA											7	60					0	0	0.001984	0	0
ITGAX	3687	broad.mit.edu	37	16	31384586	31384586	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:31384586G>T	uc002ebu.1	+	20	2450	c.2383G>T	c.(2383-2385)GTG>TTG	p.V795L	ITGAX_uc002ebt.2_Missense_Mutation_p.V795L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	795	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTCCCTGCTGGTGGGGAGTAA	0.542			NA											18	79					4.35082e-09	5.49032e-09	0.010504	1	0
ARMC5	79798	broad.mit.edu	37	16	31474186	31474186	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:31474186C>G	uc002ecc.2	+	3	1847	c.1318C>G	c.(1318-1320)CCT>GCT	p.P440A	ARMC5_uc010vfn.1_Missense_Mutation_p.P535A|ARMC5_uc010vfo.1_Missense_Mutation_p.P472A|ARMC5_uc002eca.3_Missense_Mutation_p.P440A|ARMC5_uc010vfp.1_Missense_Mutation_p.P248A|ARMC5_uc002ecb.2_Missense_Mutation_p.P440A	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	440	ARM 7.						binding			pancreas(1)	1						CTGGGACTTTCCTGAGGAGAG	0.627			NA											3	14					0	0	0.004672	0	0
CDH8	1006	broad.mit.edu	37	16	62055216	62055216	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:62055216G>A	uc002eog.1	-	2	344	c.92C>T	c.(91-93)CCG>CTG	p.P31L		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	31					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CTGATTCATCGGAGCCATGTA	0.458			NA											5	45					0	0	0.000602	0	0
ZNF821	55565	broad.mit.edu	37	16	71913844	71913844	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:71913844G>A	uc010vmj.1	-	2	382	c.6C>T	c.(4-6)TCC>TCT	p.S2S	ATXN1L_uc010vmi.1_Intron|ZNF821_uc002fbe.2_5'UTR|ZNF821_uc002fbf.2_Silent_p.S2S|ZNF821_uc002fbg.3_5'UTR|ZNF821_uc002fbh.3_Silent_p.S2S|ZNF821_uc002fbi.3_5'UTR	NM_017530	NP_060000	O75541	ZN821_HUMAN	zinc finger protein 821	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTTTCCGACGGGACATGTTTC	0.448			NA											14	153					0	0	0.004007	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369751	77369751	+	Silent	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:77369751G>T	uc002ffc.3	-	12	2180	c.1761C>A	c.(1759-1761)CCC>CCA	p.P587P	ADAMTS18_uc010chc.1_Silent_p.P175P|ADAMTS18_uc002ffe.1_Silent_p.P283P	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	587					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGCCGTGGATGGGCCGGGGCC	0.577			NA											56	98					2.6711e-34	4.2577e-34	0.01441	1	0
ACSF3	197322	broad.mit.edu	37	16	89178532	89178532	+	Silent	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr16:89178532G>T	uc002fmp.2	+	5	1195	c.855G>T	c.(853-855)CCG>CCT	p.P285P	ACSF3_uc010cig.1_Silent_p.P285P|ACSF3_uc010cih.1_Silent_p.P20P|ACSF3_uc002fmq.1_RNA|ACSF3_uc010cii.1_RNA|ACSF3_uc002fmr.1_Silent_p.P20P	NM_174917	NP_777577	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3 precursor	285					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0281)		CTGAAACGCCGCGGATCAATG	0.532			NA											49	114					2.24722e-20	3.47745e-20	0.01441	1	0
RANGRF	29098	broad.mit.edu	37	17	8193136	8193136	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:8193136A>G	uc002gkv.2	+	5	561	c.443A>G	c.(442-444)GAC>GGC	p.D148G	SLC25A35_uc002gku.1_Intron|SLC25A35_uc002gkt.2_Intron|RANGRF_uc002gkw.2_Nonstop_Mutation_p.*119W|RANGRF_uc002gky.2_3'UTR|RANGRF_uc002gkx.2_3'UTR|SLC25A35_uc002gkz.1_Intron	NM_016492	NP_057576	Q9HD47	MOG1_HUMAN	RAN guanine nucleotide release factor	148					protein transport	cytoplasm|nucleus	guanyl-nucleotide exchange factor activity				0						CCAAGCCCTGACAACAGGTCA	0.542			NA											11	58					0	0	0.001855	0	0
EPN2	22905	broad.mit.edu	37	17	19186997	19186997	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:19186997G>T	uc002gvd.3	+	3	1013	c.565G>T	c.(565-567)GCC>TCC	p.A189S	EPN2_uc002gvc.2_Missense_Mutation_p.A189S|EPN2_uc010vyn.1_Missense_Mutation_p.A189S|EPN2_uc010cql.1_Intron|EPN2_uc002gve.3_Missense_Mutation_p.A189S|EPN2_uc002gvf.3_Intron|EPN2_uc010vyo.1_Intron|EPN2_uc002gvg.1_Missense_Mutation_p.A189S|EPN2_uc010vyp.1_Missense_Mutation_p.A189S|EPN2_uc010vyq.1_Missense_Mutation_p.A189S|EPN2_uc002gvh.1_Missense_Mutation_p.A189S	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	189					endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					GTATGGCAAGGCCGGGGGCTC	0.627			NA											3	22					1.024e-07	1.23345e-07	0.000602	1	0
KRT35	3886	broad.mit.edu	37	17	39633315	39633315	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:39633315C>T	uc002hws.2	-	7	1404	c.1361G>A	c.(1360-1362)CGG>CAG	p.R454Q		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	454	Tail.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				CTCTCAGAACCGACCCCCTGG	0.602			NA											15	49					0	0	0.008871	0	0
COIL	8161	broad.mit.edu	37	17	55028031	55028031	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:55028031C>T	uc002iuu.2	-	2	603	c.572G>A	c.(571-573)TGT>TAT	p.C191Y		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	191	Lys-rich (basic).					Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					TTTATATTCACATTTCTCCTT	0.393			NA											34	50					0	0	0.003271	0	0
ITGB4	3691	broad.mit.edu	37	17	73738716	73738716	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:73738716G>T	uc002jpg.2	+	25	3023	c.2836G>T	c.(2836-2838)GTG>TTG	p.V946L	ITGB4_uc002jph.2_Missense_Mutation_p.V946L|ITGB4_uc002jpi.3_Missense_Mutation_p.V946L|ITGB4_uc010dgp.1_Missense_Mutation_p.G958V|ITGB4_uc002jpj.2_Missense_Mutation_p.V946L	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	946	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGACGTACGGGTGCCCCTCTT	0.687			NA											14	57					1.02788e-11	1.37919e-11	0.00499	1	0
CSNK1D	1453	broad.mit.edu	37	17	80210968	80210968	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:80210968C>A	uc002kej.2	-	4	805	c.489G>T	c.(487-489)CAG>CAT	p.Q163H	SLC16A3_uc002kee.2_Intron|CSNK1D_uc002kef.2_Missense_Mutation_p.Q163H|CSNK1D_uc002kei.2_Missense_Mutation_p.Q163H|CSNK1D_uc010wvj.1_Intron|CSNK1D_uc010dil.2_5'Flank|CSNK1D_uc002keh.2_Missense_Mutation_p.Q28H|CSNK1D_uc010dim.1_5'Flank	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	163	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			AGGGGATGTGCTGGTGGGTGC	0.602			NA											17	97					3.41278e-10	4.43871e-10	0.00499	1	0
ARHGAP28	79822	broad.mit.edu	37	18	6873574	6873574	+	Splice_Site	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr18:6873574G>T	uc010wzi.1	+	7	827	c.589_splice	c.e7+1	p.D197_splice	ARHGAP28_uc002knc.2_Splice_Site_p.D322_splice|ARHGAP28_uc002knd.2_Splice_Site_p.D215_splice|ARHGAP28_uc002kne.2_Splice_Site_p.D215_splice|ARHGAP28_uc002knf.2_Splice_Site_p.D206_splice			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;						signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				AAAGGACGAGGTAACTAAGAA	0.358			NA											8	55					0.00621372	0.00665307	0.006214	1	0
MC2R	4158	broad.mit.edu	37	18	13885199	13885199	+	Missense_Mutation	SNP	C	C	T	rs104894661		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr18:13885199C>T	uc002ksp.1	-	2	496	c.319G>A	c.(319-321)GAC>AAC	p.D107N		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	107	Helical; Name=3; (By similarity).		D -> N (in GCCD1).		G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	AACAGGGAGTCGATGATGTCA	0.498	Colon(141;1584 1782 35999 48227 48692)		NA											9	51					0	0	0.006214	0	0
CABYR	26256	broad.mit.edu	37	18	21736900	21736900	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr18:21736900C>A	uc002kux.2	+	4	1587	c.1435C>A	c.(1435-1437)CTT>ATT	p.L479I	CABYR_uc010xbb.1_Missense_Mutation_p.L381I|CABYR_uc002kuy.2_Intron|CABYR_uc002kuz.2_Intron|CABYR_uc002kva.2_Missense_Mutation_p.L461I|CABYR_uc002kvb.2_Intron|CABYR_uc002kvc.2_Intron|CABYR_uc010dlw.2_RNA	NM_012189	NP_036321	O75952	CABYR_HUMAN	calcium-binding tyrosine	479					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding				0	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					TCCAGAAGGCCTTACTGCACC	0.468			NA											14	26					6.31663e-08	7.65214e-08	0.003163	1	0
SS18	6760	broad.mit.edu	37	18	23619334	23619334	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr18:23619334T>C	uc002kvm.2	-	6	772	c.694A>G	c.(694-696)ATG>GTG	p.M232V	SS18_uc002kvn.2_Missense_Mutation_p.M232V|SS18_uc010xbf.1_Missense_Mutation_p.M150V|SS18_uc010xbg.1_Missense_Mutation_p.M180V|SS18_uc010xbh.1_Missense_Mutation_p.M180V|SS18_uc010xbi.1_Missense_Mutation_p.M209V|SS18_uc010dlz.1_Missense_Mutation_p.M180V	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	232	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					ATCATTCCCATAGGTGGCTGC	0.478			NA	T	SSX1| SSX2	synovial sarcoma								40	110					0	0	0.006999	0	0
SERPINB4	6318	broad.mit.edu	37	18	61328409	61328409	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr18:61328409G>A	uc002ljg.2	-	1	68	c.42C>T	c.(40-42)GAC>GAT	p.D14D	SERPINB3_uc002lji.2_Silent_p.D14D|SERPINB3_uc010dqa.2_Silent_p.D14D|SERPINB3_uc010dqb.2_Silent_p.D14D|SERPINB3_uc010dqc.2_Silent_p.D14D			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	14					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GTTGGAACAGGTCGAACATGA	0.433			NA											12	188					0	0	0.010729	0	0
TUBB4	10382	broad.mit.edu	37	19	6496074	6496074	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:6496074C>T	uc002mfg.1	-	4	543	c.436G>A	c.(436-438)GGA>AGA	p.G146R	TUBB4_uc002mff.1_Missense_Mutation_p.G74R	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	146	GTP (Potential).				'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GTGCCCATTCCGGACCCCGTG	0.637			NA											8	60					0	0	0.006214	0	0
MUC16	94025	broad.mit.edu	37	19	9067611	9067611	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:9067611G>T	uc002mkp.2	-	3	20039	c.19835C>A	c.(19834-19836)GCC>GAC	p.A6612D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6614	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTGAGTAGGCTGGGACAGA	0.443			NA											49	87					2.82306e-37	4.53401e-37	0.01441	1	0
MUC16	94025	broad.mit.edu	37	19	9076071	9076071	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:9076071A>G	uc002mkp.2	-	3	11579	c.11375T>C	c.(11374-11376)ATG>ACG	p.M3792T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3793	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTCCTTGCCATTGCAGCTGG	0.507			NA											45	65					0	0	0.01441	0	0
ZNF560	147741	broad.mit.edu	37	19	9580363	9580363	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:9580363G>T	uc002mlp.1	-	8	682	c.472C>A	c.(472-474)CTG>ATG	p.L158M	ZNF560_uc010dwr.1_Missense_Mutation_p.L52M	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	158	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						CAAGAGATCAGACTGGGTTTG	0.473			NA											11	26					1.5842e-08	1.96404e-08	0.001855	1	0
CHST8	64377	broad.mit.edu	37	19	34263626	34263626	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:34263626C>T	uc002nus.3	+	5	1438	c.933C>T	c.(931-933)TTC>TTT	p.F311F	CHST8_uc002nut.3_Silent_p.F311F|CHST8_uc002nuu.2_Silent_p.F311F	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	311	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					TTCCCGAGTTCGTCCAGTACC	0.652			NA											5	47					0	0	0.001168	0	0
ZNF585A	199704	broad.mit.edu	37	19	37646813	37646813	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:37646813C>T	uc002ofo.1	-	4	477	c.246G>A	c.(244-246)AAG>AAA	p.K82K	ZNF585A_uc002ofm.1_Silent_p.K27K|ZNF585A_uc002ofn.1_Silent_p.K27K	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	82	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCCATGGTTCCTTTCCTTGCT	0.527			NA											20	66					0	0	0.00278	0	0
FCGBP	8857	broad.mit.edu	37	19	40357618	40357618	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:40357618C>T	uc002omp.3	-	34	15703	c.15695G>A	c.(15694-15696)CGT>CAT	p.R5232H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5232						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACAGAGACCACGGGTGGCCCA	0.627			NA											3	63					0	0	0.004672	0	0
ZNF235	9310	broad.mit.edu	37	19	44792290	44792290	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:44792290C>T	uc002oza.3	-	5	1401	c.1298G>A	c.(1297-1299)TGT>TAT	p.C433Y	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Missense_Mutation_p.C429Y|ZNF235_uc010xwx.1_Missense_Mutation_p.C347Y	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	433	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				ACAATCCCCACATTTATATGG	0.418			NA											18	58					0	0	0.007413	0	0
CPT1C	126129	broad.mit.edu	37	19	50208359	50208359	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:50208359G>T	uc002ppj.2	+	8	1072	c.867G>T	c.(865-867)CAG>CAT	p.Q289H	CPT1C_uc002ppl.3_Missense_Mutation_p.Q255H|CPT1C_uc002ppi.2_Missense_Mutation_p.Q206H|CPT1C_uc002ppk.2_Missense_Mutation_p.Q278H|CPT1C_uc010eng.2_Missense_Mutation_p.Q289H|CPT1C_uc010enh.2_Missense_Mutation_p.Q289H|CPT1C_uc010ybc.1_Missense_Mutation_p.Q127H|CPT1C_uc010eni.1_5'Flank	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	289	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TGAACCGCCAGGAGATACCCC	0.662			NA											17	55					1.78486e-19	2.72224e-19	0.007413	1	0
SIGLEC6	946	broad.mit.edu	37	19	52033113	52033113	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:52033113G>T	uc002pwy.2	-	5	1039	c.877C>A	c.(877-879)CTG>ATG	p.L293M	SIGLEC6_uc002pwz.2_Missense_Mutation_p.L277M|SIGLEC6_uc002pxa.2_Missense_Mutation_p.L293M|SIGLEC6_uc010ydb.1_Missense_Mutation_p.L230M|SIGLEC6_uc010ydc.1_Missense_Mutation_p.L293M|SIGLEC6_uc010eoz.1_Missense_Mutation_p.L271M|SIGLEC6_uc010epb.1_Missense_Mutation_p.L246M|SIGLEC6_uc010epa.1_Missense_Mutation_p.L282M	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	293	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GTGGCGTTCAGGGCGGGGAAG	0.642			NA											19	63					3.08376e-08	3.77895e-08	0.00333	1	0
ZNF331	55422	broad.mit.edu	37	19	54080559	54080559	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:54080559G>A	uc002qbx.1	+	7	2179	c.745G>A	c.(745-747)GGG>AGG	p.G249R	ZNF331_uc002qby.1_Missense_Mutation_p.G249R|ZNF331_uc002qbz.1_Missense_Mutation_p.G249R|ZNF331_uc002qca.1_Missense_Mutation_p.G249R|ZNF331_uc010eqr.1_Missense_Mutation_p.G249R|ZNF331_uc002qcb.1_Missense_Mutation_p.G249R|ZNF331_uc002qcc.1_Missense_Mutation_p.G249R|ZNF331_uc002qcd.1_Missense_Mutation_p.G249R	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	249	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CAAAGACTGTGGGAAGACCTT	0.458			NA	T	?	follicular thyroid adenoma								25	56					0	0	0.007291	0	0
ALK	238	broad.mit.edu	37	2	29543738	29543738	+	Silent	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:29543738A>T	uc002rmy.2	-	7	2332	c.1425T>A	c.(1423-1425)CCT>CCA	p.P475P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	475	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AAAAACCCACAGGCAGTTTCC	0.502			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				11	74					0	0	0.013537	0	0
VRK2	7444	broad.mit.edu	37	2	58313494	58313494	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:58313494A>G	uc002rzo.2	+	8	1022	c.277A>G	c.(277-279)AAA>GAA	p.K93E	VRK2_uc010fcb.2_Missense_Mutation_p.K93E|VRK2_uc002rzs.2_Missense_Mutation_p.K93E|VRK2_uc002rzr.2_Missense_Mutation_p.K93E|VRK2_uc010fcc.2_5'UTR|VRK2_uc002rzv.2_Missense_Mutation_p.K93E|VRK2_uc010fcd.2_Missense_Mutation_p.K70E|VRK2_uc002rzp.2_Missense_Mutation_p.K93E|VRK2_uc010ypg.1_Missense_Mutation_p.K93E|VRK2_uc002rzq.2_Missense_Mutation_p.K93E|VRK2_uc002rzu.2_Missense_Mutation_p.K93E|VRK2_uc002rzt.2_5'UTR|VRK2_uc010yph.1_5'UTR	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	93	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						GATAGAACGCAAACAACTTGA	0.274			NA											15	90					0	0	0.00499	0	0
GPR45	11250	broad.mit.edu	37	2	105858376	105858376	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:105858376G>A	uc002tco.1	+	1	177	c.61G>A	c.(61-63)GCC>ACC	p.A21T		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	21	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CACCAGCAACGCCTCAGACTC	0.602			NA											39	83					0	0	0.01441	0	0
THSD7B	80731	broad.mit.edu	37	2	137814416	137814416	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:137814416C>A	uc002tva.1	+	2	473	c.473C>A	c.(472-474)TCC>TAC	p.S158Y	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.S48Y	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTACCATGGTCCAACTGTAGC	0.488			NA											71	228					1.91593e-42	3.10059e-42	0.01441	1	0
CCDC148	130940	broad.mit.edu	37	2	159196795	159196795	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:159196795G>A	uc002tzq.2	-	5	708	c.445C>T	c.(445-447)CAC>TAC	p.H149Y	CCDC148_uc002tzr.2_Intron|CCDC148_uc010foh.2_Intron|CCDC148_uc010foi.1_Missense_Mutation_p.H96Y|CCDC148_uc010foj.1_Intron|CCDC148_uc010fok.1_Missense_Mutation_p.H63Y|CCDC148_uc002tzs.1_Missense_Mutation_p.H149Y	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	149										ovary(2)	2						ATATGTGGGTGTGAATGCTGC	0.338			NA											3	88					0	0	0.004672	0	0
BAZ2B	29994	broad.mit.edu	37	2	160241699	160241699	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:160241699A>T	uc002uao.2	-	23	4005	c.3653T>A	c.(3652-3654)ATC>AAC	p.I1218N	BAZ2B_uc002uap.2_Missense_Mutation_p.I1182N	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CAGTTCATTGATCAGGAAAGC	0.418			NA											18	133					0	0	0.00278	0	0
G6PC2	57818	broad.mit.edu	37	2	169764282	169764282	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:169764282C>T	uc002uem.2	+	5	853	c.761C>T	c.(760-762)ACG>ATG	p.T254M	G6PC2_uc002uen.2_3'UTR|G6PC2_uc010fpv.2_Missense_Mutation_p.T138M	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	254	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						ATTGACACCACGCCTTTTGCT	0.522			NA											17	46					0	0	0.004007	0	0
DLX1	1745	broad.mit.edu	37	2	172951500	172951500	+	Silent	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:172951500C>T	uc002uhl.2	+	2	630	c.432C>T	c.(430-432)AAC>AAT	p.N144N	DLX1_uc010fqj.1_Silent_p.N144N|DLX1_uc002uhm.2_Intron	NM_178120	NP_835221	P56177	DLX1_HUMAN	distal-less homeobox 1 isoform 1	144	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AGGCTTTGAACCGGAGGTTCC	0.572			NA											52	152					0	0	0.01441	0	0
TTN	7273	broad.mit.edu	37	2	179667046	179667046	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:179667046G>A	uc002und.2	-	3	339	c.114C>T	c.(112-114)AGC>AGT	p.S38S	TTN_uc010zfg.1_Silent_p.S38S|TTN_uc010zfh.1_Silent_p.S38S|TTN_uc010zfi.1_Silent_p.S38S|TTN_uc010zfj.1_Silent_p.S38S|TTN_uc002unb.2_Silent_p.S38S			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	38							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTAAACCAGCTCACCTCAG	0.522			NA											4	11					0	0	0.009096	0	0
PDE1A	5136	broad.mit.edu	37	2	183387015	183387015	+	Missense_Mutation	SNP	C	C	A	rs137961386	byFrequency	TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:183387015C>A	uc002uos.2	-	2	173	c.89G>T	c.(88-90)CGC>CTC	p.R30L	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Missense_Mutation_p.R30L|PDE1A_uc010zfq.1_Missense_Mutation_p.R30L|PDE1A_uc002uov.1_RNA	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	30	Calmodulin-binding (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TCCTTTCAGGCGCTGCCACAT	0.418			NA											7	34					0.000157383	0.000176536	0.00308	1	0
ATG16L1	55054	broad.mit.edu	37	2	234178672	234178672	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr2:234178672A>T	uc002vty.2	+	6	923	c.666A>T	c.(664-666)AAA>AAT	p.K222N	ATG16L1_uc002vtx.1_Missense_Mutation_p.K78N|ATG16L1_uc002vua.2_Missense_Mutation_p.K222N|ATG16L1_uc002vub.2_Missense_Mutation_p.K99N|ATG16L1_uc002vtz.2_Missense_Mutation_p.K78N|ATG16L1_uc002vud.3_Missense_Mutation_p.K138N	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	222	Potential.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GGCTGCAGAAAGAGCTTGCAG	0.428			NA											19	40					0	0	0.012319	0	0
TMEM90B	79953	broad.mit.edu	37	20	24524042	24524042	+	Silent	SNP	G	G	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr20:24524042G>C	uc002wtw.1	+	2	942	c.309G>C	c.(307-309)GGG>GGC	p.G103G		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	103	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						GCTCCTGGGGGGACGGTGTGG	0.632			NA											22	84					0	0	0.003954	0	0
NFATC2	4773	broad.mit.edu	37	20	50139803	50139803	+	Missense_Mutation	SNP	C	C	A	rs145325613	byFrequency	TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr20:50139803C>A	uc002xwd.2	-	2	1197	c.977G>T	c.(976-978)AGC>ATC	p.S326I	NFATC2_uc002xwc.2_Missense_Mutation_p.S326I|NFATC2_uc010zyv.1_Missense_Mutation_p.S107I|NFATC2_uc010zyw.1_Missense_Mutation_p.S107I|NFATC2_uc010zyx.1_Missense_Mutation_p.S306I|NFATC2_uc010zyy.1_Missense_Mutation_p.S107I|NFATC2_uc010zyz.1_Missense_Mutation_p.S107I|NFATC2_uc002xwe.2_Missense_Mutation_p.S306I	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	326					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGGGTCAGGGCTGGTCTTCCA	0.692			NA											17	37					5.03518e-11	6.67162e-11	0.007413	1	0
CSTF1	1477	broad.mit.edu	37	20	54972262	54972262	+	Splice_Site	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr20:54972262G>T	uc002xxl.1	+	3	370	c.170_splice	c.e3-1	p.G57_splice	CSTF1_uc002xxm.1_Splice_Site_p.G57_splice|CSTF1_uc002xxn.1_Splice_Site_p.G57_splice|CSTF1_uc002xxo.1_Splice_Site	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			ATTTCTTTCAGGAATGGAAAA	0.403			NA											18	43					3.51602e-12	4.809e-12	0.008871	1	0
DIDO1	11083	broad.mit.edu	37	20	61511164	61511164	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr20:61511164G>A	uc002ydr.1	-	16	6408	c.6144C>T	c.(6142-6144)TCC>TCT	p.S2048S	DIDO1_uc002yds.1_Silent_p.S2048S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2048					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					AGGAGAGCGCGGAGGGCGGCC	0.721	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											19	43					0	0	0.007413	0	0
KRTAP21-2	337978	broad.mit.edu	37	21	32119349	32119349	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr21:32119349C>A	uc011adh.1	-	1	172	c.172G>T	c.(172-174)GGA>TGA	p.G58*		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	58						intermediate filament					0						cagccatatccacagccagag	0.199			NA											18	52					1.33834e-09	1.7092e-09	0.007413	1	0
MN1	4330	broad.mit.edu	37	22	28194031	28194031	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr22:28194031T>C	uc003adj.2	-	1	3456	c.2501A>G	c.(2500-2502)AAC>AGC	p.N834S		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	834							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GGCGATCATGTTCTGGCAAGC	0.617			NA	T	ETV6	AML|meningioma								33	83					0	0	0.003271	0	0
RASD2	23551	broad.mit.edu	37	22	35943106	35943106	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr22:35943106C>A	uc003anx.2	+	2	455	c.250C>A	c.(250-252)CGC>AGC	p.R84S	RASD2_uc003any.2_Missense_Mutation_p.R84S	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	84					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CCCCGCCATGCGCAGGCTGTC	0.637			NA											24	66					1.836e-18	2.76051e-18	0.003755	1	0
ULK4	54986	broad.mit.edu	37	3	41953070	41953070	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:41953070G>T	uc003ckv.3	-	10	1179	c.978C>A	c.(976-978)CAC>CAA	p.H326Q	ULK4_uc003ckw.2_Missense_Mutation_p.H326Q|ULK4_uc003ckx.1_Missense_Mutation_p.H326Q	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	326							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GACCACTCTTGTGCCCTTTTG	0.408			NA											5	34					3.59834e-05	4.14591e-05	0.001168	1	0
RNF123	63891	broad.mit.edu	37	3	49758482	49758482	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:49758482C>G	uc003cxh.2	+	38	3854	c.3768C>G	c.(3766-3768)ATC>ATG	p.I1256M	RNF123_uc003cxi.2_RNA|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1256	RING-type.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TCTGCCCCATCTGCTATGCCC	0.607			NA											5	67					0	0	0.001168	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64587701	64587701	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:64587701C>G	uc003dmg.2	-	26	3968	c.3936G>C	c.(3934-3936)GAG>GAC	p.E1312D	ADAMTS9_uc011bfo.1_Missense_Mutation_p.E1284D|ADAMTS9_uc003dmh.1_Missense_Mutation_p.E1141D|ADAMTS9_uc011bfp.1_Missense_Mutation_p.E223D	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1312					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GACGATAGTCCTCATTTTGGA	0.572			NA											44	69					0	0	0.013114	0	0
PLA1A	51365	broad.mit.edu	37	3	119347694	119347694	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:119347694T>C	uc003ecu.2	+	10	1307	c.1268T>C	c.(1267-1269)CTT>CCT	p.L423P	PLA1A_uc003ecv.2_Missense_Mutation_p.L407P|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Missense_Mutation_p.L250P	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	423	Involved in the recognition of diacyl- phospholipids.				lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						TGCACTGCCCTTTTGCCTGTC	0.458			NA											3	113					0	0	0.009096	0	0
UROC1	131669	broad.mit.edu	37	3	126219611	126219611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:126219611G>A	uc003eiz.1	-	11	1104	c.1072C>T	c.(1072-1074)CAG>TAG	p.Q358*	UROC1_uc010hsi.1_Nonsense_Mutation_p.Q418*	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	358					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		AAGCTGAGCTGCACAGGGTAG	0.602			NA											14	98					0	0	0.001855	0	0
SR140	23350	broad.mit.edu	37	3	142769829	142769829	+	Nonsense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:142769829A>T	uc003evh.1	+	25	2692	c.2593A>T	c.(2593-2595)AAA>TAA	p.K865*	SR140_uc003evi.1_Nonsense_Mutation_p.K456*|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Nonsense_Mutation_p.K864*|SR140_uc003evl.1_Nonsense_Mutation_p.K432*	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	865	Potential.|Glu-rich.				RNA processing	nucleus	nucleotide binding|RNA binding				0						GAAAAGACCTAAAAAACCAGG	0.318	Colon(87;897 1320 15089 19747 35974)		NA											5	17					0	0	0.001168	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198095	170198095	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:170198095G>A	uc003fgz.2	-	7	2292	c.1976C>T	c.(1975-1977)GCG>GTG	p.A659V	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	659	Helical; (Potential).					integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GCACCAGACCGCAAACCGGAT	0.498			NA											3	100					0	0	0.009096	0	0
MFN1	55669	broad.mit.edu	37	3	179085233	179085233	+	Nonsense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:179085233A>T	uc003fjs.2	+	8	886	c.760A>T	c.(760-762)AGA>TGA	p.R254*	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Nonsense_Mutation_p.R282*|MFN1_uc010hxc.2_Nonsense_Mutation_p.R107*	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	254	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GTAGGTACGCAGACAGCACAT	0.348			NA											5	40					0	0	0.000602	0	0
ECE2	9718	broad.mit.edu	37	3	183995734	183995734	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr3:183995734G>T	uc003fni.3	+	5	892	c.854G>T	c.(853-855)AGC>ATC	p.S285I	ECE2_uc011brg.1_Missense_Mutation_p.S213I|ECE2_uc011brh.1_Missense_Mutation_p.S138I|ECE2_uc003fnl.3_Missense_Mutation_p.S213I|ECE2_uc003fnm.3_Missense_Mutation_p.S167I|ECE2_uc003fnk.3_Missense_Mutation_p.S138I|ECE2_uc011bri.1_Missense_Mutation_p.S200I|ECE2_uc010hxv.2_5'UTR	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	285	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCAACTCCAGCAGTGAAGCT	0.557			NA											27	66					1.12875e-08	1.40762e-08	0.00632	1	0
CTBP1	1487	broad.mit.edu	37	4	1206184	1206184	+	Silent	SNP	G	G	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:1206184G>C	uc003gcv.1	-	9	1332	c.1167C>G	c.(1165-1167)GCC>GCG	p.A389A	uc003gcs.1_RNA|CTBP1_uc003gct.1_Silent_p.A370A|CTBP1_uc003gcu.1_Silent_p.A378A|CTBP1_uc003gcw.2_Silent_p.A64A	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	389					interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		TGCCAGTGGGGGCCACGCCCA	0.716			NA											5	7					0	0	0.001168	0	0
MAEA	10296	broad.mit.edu	37	4	1321485	1321485	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:1321485C>G	uc003gda.2	+	5	680	c.650C>G	c.(649-651)GCT>GGT	p.A217G	MAEA_uc010ibs.1_Missense_Mutation_p.A176G|MAEA_uc003gdb.2_Missense_Mutation_p.A176G|MAEA_uc011bvb.1_Missense_Mutation_p.A149G|MAEA_uc003gdc.2_Intron|MAEA_uc003gdd.2_Intron|MAEA_uc011bvc.1_Missense_Mutation_p.A216G|MAEA_uc011bvd.1_Missense_Mutation_p.A169G|MAEA_uc010ibt.2_Intron|MAEA_uc010ibu.2_5'Flank	NM_001017405	NP_001017405	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher isoform 1	217					cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			AGACTGGACGCTGTGAGGTAG	0.572			NA											13	26					0	0	0.00245	0	0
FGFR3	2261	broad.mit.edu	37	4	1808905	1808905	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:1808905C>G	uc003gdr.3	+	18	2593	c.2337C>G	c.(2335-2337)AGC>AGG	p.S779R	FGFR3_uc003gdu.2_Missense_Mutation_p.S781R|FGFR3_uc003gds.3_Missense_Mutation_p.S667R|FGFR3_uc003gdq.3_Missense_Mutation_p.L757V	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	779	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACACCCCCAGCTCCAGCTCCT	0.716			1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				2	11					0	0	0.004672	0	0
AMBN	258	broad.mit.edu	37	4	71468534	71468534	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:71468534C>A	uc003hfl.2	+	8	665	c.590C>A	c.(589-591)CCT>CAT	p.P197H		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	197	1.				bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			ATGGATTTTCCTGATCCACAA	0.204			NA											10	25					0.000151284	0.000170597	0.001855	1	0
FAT4	79633	broad.mit.edu	37	4	126373318	126373318	+	Missense_Mutation	SNP	G	G	T	rs139635339		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:126373318G>T	uc003ifj.3	+	9	11147	c.11147G>T	c.(11146-11148)CGT>CTT	p.R3716L	FAT4_uc011cgp.1_Missense_Mutation_p.R2014L|FAT4_uc003ifi.1_Missense_Mutation_p.R1194L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3716	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATCTTACTTCGTCTCGGCGTA	0.468			NA											29	81					1.06647e-15	1.54858e-15	0.003755	1	0
RXFP1	59350	broad.mit.edu	37	4	159493897	159493897	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:159493897C>A	uc003ipz.2	+	2	179	c.97C>A	c.(97-99)CCC>ACC	p.P33T	RXFP1_uc010iqj.1_5'UTR|RXFP1_uc011cja.1_5'UTR|RXFP1_uc010iqo.2_Missense_Mutation_p.P33T|RXFP1_uc011cjb.1_5'UTR|RXFP1_uc010iqk.2_5'UTR|RXFP1_uc011cjc.1_5'UTR|RXFP1_uc011cjd.1_5'UTR|RXFP1_uc010iql.2_5'UTR|RXFP1_uc011cje.1_Missense_Mutation_p.P33T|RXFP1_uc010iqm.2_Missense_Mutation_p.P33T|RXFP1_uc011cjf.1_5'UTR|RXFP1_uc010iqn.2_Intron	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	33	Extracellular (Potential).|LDL-receptor class A.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TGGCTATTTCCCCTGTGGGAA	0.517			NA											30	68					2.61193e-14	3.74142e-14	0.009535	1	0
TRIML1	339976	broad.mit.edu	37	4	189061712	189061712	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr4:189061712C>T	uc003izm.1	+	2	554	c.439C>T	c.(439-441)CGT>TGT	p.R147C		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	147	Potential.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAATCTTTTGCGTGTAAGGAG	0.473	Melanoma(31;213 1036 16579 23968 32372)		NA											8	51					0	0	0.006214	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140803124	140803124	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr5:140803124G>T	uc003lkq.1	+	1	2588	c.2330G>T	c.(2329-2331)GGG>GTG	p.G777V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.G777V|PCDHGA11_uc003lkp.1_Intron|PCDHGB8P_uc011daz.1_5'Flank	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	777	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAACTATGGGGACACGCTC	0.517			NA											43	91					2.34695e-46	3.82734e-46	0.01441	1	0
ZNF300	91975	broad.mit.edu	37	5	150276251	150276251	+	Missense_Mutation	SNP	A	A	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr5:150276251A>C	uc003lsy.1	-	6	817	c.550T>G	c.(550-552)TTC>GTC	p.F184V	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TATTTATGGAATCTCTGTATT	0.328			NA											15	48					0	0	0.00245	0	0
SQSTM1	8878	broad.mit.edu	37	5	179251243	179251243	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr5:179251243G>A	uc003mkw.3	+	4	688	c.593G>A	c.(592-594)TGG>TAG	p.W198*	SQSTM1_uc011dgr.1_Nonsense_Mutation_p.W114*|SQSTM1_uc011dgs.1_Nonsense_Mutation_p.W114*|SQSTM1_uc003mkv.3_Nonsense_Mutation_p.W198*|SQSTM1_uc003mkx.2_Nonsense_Mutation_p.W114*	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	198	Interaction with GABRR3 (By similarity).|LIM protein-binding (LB).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCCAGGATGGGAAATGGGT	0.652			NA							Paget_Disease_of_Bone				11	48					0	0	0.013537	0	0
AGER	177	broad.mit.edu	37	6	32150671	32150671	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr6:32150671C>A	uc003oal.1	-	6	662	c.638G>T	c.(637-639)GGC>GTC	p.G213V	AGER_uc003oak.1_5'UTR|AGER_uc003oar.2_Missense_Mutation_p.G112V|AGER_uc011dpm.1_Missense_Mutation_p.G112V|AGER_uc011dpn.1_Missense_Mutation_p.G112V|AGER_uc010jtv.1_Missense_Mutation_p.G213V|AGER_uc011dpo.1_Missense_Mutation_p.G126V|AGER_uc003oam.1_Intron|AGER_uc003oan.1_Missense_Mutation_p.G199V|AGER_uc003oap.1_Missense_Mutation_p.G229V|AGER_uc003oat.1_Missense_Mutation_p.G229V|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Missense_Mutation_p.G199V|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_Missense_Mutation_p.G213V|AGER_uc003oau.1_Missense_Mutation_p.G213V|AGER_uc011dpp.1_Missense_Mutation_p.G213V|AGER_uc011dpq.1_Missense_Mutation_p.G229V	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	213	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						TCGGGGAAGGCCTGGGCTGAA	0.662			NA											3	103					0.004672	0.00505339	0.004672	1	0
HCRTR2	3062	broad.mit.edu	37	6	55113507	55113507	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr6:55113507G>A	uc003pcl.2	+	2	609	c.294G>A	c.(292-294)CTG>CTA	p.L98L	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Silent_p.L33L	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	98	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATCTTTCTCTGGCTGATGTGC	0.458			NA											41	133					0	0	0.009718	0	0
FYN	2534	broad.mit.edu	37	6	112035607	112035607	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr6:112035607C>T	uc003pvj.2	-	4	627	c.287G>A	c.(286-288)CGG>CAG	p.R96Q	FYN_uc003pvi.2_Missense_Mutation_p.R96Q|FYN_uc003pvk.2_Missense_Mutation_p.R96Q|FYN_uc003pvh.2_Missense_Mutation_p.R96Q	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	96	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	ATCTTCTGTCCGTGCTTCATA	0.403			NA											9	52					0	0	0.010729	0	0
LAMA2	3908	broad.mit.edu	37	6	129637037	129637038	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr6:129637037_129637038GG>AT	uc003qbn.2	+	26	3971_3972	c.3866_3867GG>AT	c.(3865-3867)AGG>AAT	p.R1289N	LAMA2_uc003qbo.2_Missense_Mutation_p.R1289N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1289	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATTATCGTCAGGCATATGGCTG	0.421			NA											21	49					0	0	0.004672	0	0
BCLAF1	9774	broad.mit.edu	37	6	136596725	136596725	+	Silent	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr6:136596725T>C	uc003qgx.1	-	6	2050	c.1797A>G	c.(1795-1797)AAA>AAG	p.K599K	BCLAF1_uc003qgw.1_Silent_p.K426K|BCLAF1_uc003qgy.1_Silent_p.K597K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.K597K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	599					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTGAAGTGCTTTTGCTGGCCT	0.393	Colon(142;1534 1789 5427 7063 28491)		NA											9	104					0	0	0.00245	0	0
C6orf72	116254	broad.mit.edu	37	6	149893739	149893739	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr6:149893739G>T	uc003qmq.1	+	3	304	c.277G>T	c.(277-279)GTG>TTG	p.V93L	C6orf72_uc010kie.1_Intron	NM_138785	NP_620140	Q9NU53	CF072_HUMAN	hypothetical protein LOC116254 precursor	93	Extracellular (Potential).					integral to membrane					0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.66e-12)|GBM - Glioblastoma multiforme(68;0.171)		GACTTTGATAGGTGAGTATTA	0.259			NA											11	17					2.27111e-07	2.68981e-07	0.013537	1	0
CARD11	84433	broad.mit.edu	37	7	2983872	2983872	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:2983872T>A	uc003smv.2	-	5	1062	c.658A>T	c.(658-660)ATG>TTG	p.M220L		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	220	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CGGCTCCTCATGACCGCCATG	0.582			NA	Mis		DLBCL								8	40					0	0	0.004482	0	0
COL28A1	340267	broad.mit.edu	37	7	7476096	7476096	+	Splice_Site	SNP	T	T	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:7476096T>C	uc003src.1	-	23	1909	c.1792_splice	c.e23-1	p.G598_splice	COL28A1_uc011jxe.1_Splice_Site_p.G281_splice|COL28A1_uc003srd.2_Splice_Site_p.G153_splice|COL28A1_uc003sre.1_Splice_Site_p.G19_splice	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor						cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TCTATCTCCCTGTACATTTCA	0.398			NA											23	38					0	0	0.005443	0	0
LANCL2	55915	broad.mit.edu	37	7	55468954	55468954	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:55468954C>T	uc003tqp.2	+	5	1344	c.766C>T	c.(766-768)CGG>TGG	p.R256W		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	256					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			CCAGTGGCACCGGAAGCAGTA	0.438			NA											16	101					0	0	0.006122	0	0
ZNF716	441234	broad.mit.edu	37	7	57529215	57529215	+	Nonsense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:57529215A>T	uc011kdi.1	+	4	1160	c.1048A>T	c.(1048-1050)AAA>TAA	p.K350*		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TACTGGGGAGAAACTCTACAC	0.398			NA											4	19					0	0	0.009096	0	0
AP1S1	1174	broad.mit.edu	37	7	100799899	100799899	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:100799899C>G	uc003uxv.3	+	2	138	c.28C>G	c.(28-30)CGG>GGG	p.R10G		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	10					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					ATTATTCAGCCGGCAGGGAAA	0.527			NA											8	13					0	0	0.010729	0	0
CAV2	858	broad.mit.edu	37	7	116146056	116146056	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:116146056A>T	uc003vid.2	+	3	762	c.370A>T	c.(370-372)ATG>TTG	p.M124L	CAV2_uc003vhv.2_RNA|CAV2_uc003vhw.2_RNA|CAV2_uc003vhx.2_RNA|CAV2_uc010lkb.1_RNA|CAV2_uc010lkc.2_RNA|CAV2_uc003vib.2_RNA|CAV2_uc003vhz.2_RNA|CAV2_uc003via.2_RNA|CAV1_uc010lkd.1_5'UTR|CAV1_uc010lke.1_5'UTR|CAV2_uc003vie.2_Missense_Mutation_p.N61I	NM_001233	NP_001224	P51636	CAV2_HUMAN	caveolin 2 isoform a and b	124	Cytoplasmic (Potential).				caveola assembly|endoplasmic reticulum organization|mitochondrion organization|negative regulation of endothelial cell proliferation|positive regulation of dopamine receptor signaling pathway|regulation of mitosis|skeletal muscle fiber development|vesicle docking|vesicle fusion	caveola|extrinsic to internal side of plasma membrane|Golgi membrane|integral to plasma membrane|membrane fraction|nucleus|perinuclear region of cytoplasm|transport vesicle	D1 dopamine receptor binding|protein homodimerization activity				0	all_epithelial(6;1.53e-06)|Lung NSC(10;0.00592)|all_lung(10;0.00642)		STAD - Stomach adenocarcinoma(10;0.00878)			GACCTGCCTAATGGTTCTGCC	0.433			NA											10	44					0	0	0.006214	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652317	121652317	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:121652317A>T	uc003vjy.2	+	12	3612	c.3217A>T	c.(3217-3219)AAC>TAC	p.N1073Y	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1073	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						AGTCATGCCCAACATGTATGA	0.393			NA											16	51					0	0	0.006122	0	0
GRM8	2918	broad.mit.edu	37	7	126173883	126173883	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:126173883A>T	uc003vlr.2	-	8	1864	c.1553T>A	c.(1552-1554)CTG>CAG	p.L518Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.L518Q|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	518	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTTACACGGCAGGCTGCAGAC	0.522			NA								HNSCC(24;0.065)			13	93					0	0	0.001855	0	0
AKR1B10	57016	broad.mit.edu	37	7	134216666	134216666	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:134216666C>T	uc003vrr.2	+	3	561	c.241C>T	c.(241-243)CCC>TCC	p.P81S		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	81					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						GCAGTTGTGGCCCACTTTCTT	0.458			NA											12	54					0	0	0.013537	0	0
MGAM	8972	broad.mit.edu	37	7	141803165	141803165	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:141803165C>T	uc003vwy.2	+	47	5476	c.5422C>T	c.(5422-5424)CCC>TCC	p.P1808S		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1808	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGGCAGTGTCCCCGTTACCAG	0.453			NA											3	18					0	0	0.004672	0	0
ZYX	7791	broad.mit.edu	37	7	143079991	143079991	+	Missense_Mutation	SNP	G	G	T	rs150223874		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:143079991G>T	uc003wcw.2	+	5	754	c.599G>T	c.(598-600)TGG>TTG	p.W200L	ZYX_uc011ktd.1_Missense_Mutation_p.W43L|ZYX_uc003wcx.2_Missense_Mutation_p.W200L|ZYX_uc011kte.1_Missense_Mutation_p.W169L|ZYX_uc011ktf.1_Missense_Mutation_p.W43L	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	200					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CTGCCTCCTTGGAAGTCCCCT	0.537			NA											11	64					0.00829132	0.0087888	0.008291	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147675028	147675028	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:147675028G>T	uc003weu.1	+	15	2846	c.2330G>T	c.(2329-2331)CGT>CTT	p.R777L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	777	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GATACTGACCGTCAAGGCTCA	0.473			NA								HNSCC(39;0.1)			3	60					6.4e-05	7.25721e-05	0.004672	1	0
SSPO	23145	broad.mit.edu	37	7	149525062	149525062	+	Silent	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:149525062G>T	uc010lpk.2	+	107	14970	c.14970G>T	c.(14968-14970)GGG>GGT	p.G4990G	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_RNA|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4990	VWFC 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCACCTTGGGCGTCCCCACC	0.672			NA											5	34					2.7689e-08	3.41283e-08	0.001984	1	0
SOX7	83595	broad.mit.edu	37	8	10583375	10583376	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr8:10583375_10583376CC>AA	uc003wtf.2	-	2	1118_1119	c.1039_1040GG>TT	c.(1039-1041)GGG>TTG	p.G347L	SOX7_uc011kwz.1_Missense_Mutation_p.G399L	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	347	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGCCATGGCCCCTGTGGCGGAG	0.619			NA											6	45					0	0	0.004672	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885446	88885446	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr8:88885446C>T	uc003ydz.2	-	1	851	c.754G>A	c.(754-756)GAT>AAT	p.D252N		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	252										ovary(1)	1						CAGCGCAGATCAATGCCAAAG	0.507			NA											12	151					0	0	0.00245	0	0
CSMD3	114788	broad.mit.edu	37	8	113237134	113237134	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr8:113237134C>A	uc003ynu.2	-	71	11149	c.10990G>T	c.(10990-10992)GGA>TGA	p.G3664*	CSMD3_uc003yns.2_Nonsense_Mutation_p.G2866*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.G3624*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.G3495*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3664	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTGAACATCCTGTATACTGT	0.403			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	191					1.52009e-12	2.10627e-12	0.003163	1	0
TRPS1	7227	broad.mit.edu	37	8	116599521	116599521	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr8:116599521G>A	uc003ynz.2	-	4	2827	c.2368C>T	c.(2368-2370)CGC>TGC	p.R790C	TRPS1_uc011lhy.1_Missense_Mutation_p.R794C|TRPS1_uc003yny.2_Missense_Mutation_p.R803C|TRPS1_uc010mcy.2_Missense_Mutation_p.R790C	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	790	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTCACATTGCGAAGGTCATCA	0.567			NA							Langer-Giedion_syndrome				55	588					0	0	0.01441	0	0
TAF2	6873	broad.mit.edu	37	8	120758944	120758944	+	Splice_Site	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr8:120758944C>A	uc003you.2	-	23	3378	c.3108_splice	c.e23+1	p.P1036_splice		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2						G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GTGATTCTTACAGGGTTCTGA	0.388			NA											92	94					1.41191e-52	2.32034e-52	0.01441	1	0
OC90	729330	broad.mit.edu	37	8	133053374	133053374	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr8:133053374T>A	uc003ytg.2	-	4	326	c.326A>T	c.(325-327)GAG>GTG	p.E109V	OC90_uc011lix.1_Missense_Mutation_p.E125V	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	125	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			AGCGGCCTCCTCATAGCACCT	0.567			NA											84	89					0	0	0.01441	0	0
JAK2	3717	broad.mit.edu	37	9	5080270	5080270	+	Nonsense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:5080270G>T	uc010mhm.2	+	16	2286	c.2173G>T	c.(2173-2175)GAA>TAA	p.E725*	JAK2_uc003ziw.2_Nonsense_Mutation_p.E725*	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	725	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TGAATGCATTGAAAATCCTAA	0.363			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				53	84					1.78197e-24	2.79835e-24	0.01441	1	0
PTPRD	5789	broad.mit.edu	37	9	8340408	8340408	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:8340408G>A	uc003zkk.2	-	41	5899	c.5188C>T	c.(5188-5190)CGG>TGG	p.R1730W	PTPRD_uc003zkp.2_Missense_Mutation_p.R1324W|PTPRD_uc003zkq.2_Missense_Mutation_p.R1323W|PTPRD_uc003zkr.2_Missense_Mutation_p.R1314W|PTPRD_uc003zks.2_Missense_Mutation_p.R1323W|PTPRD_uc003zkl.2_Missense_Mutation_p.R1721W|PTPRD_uc003zkm.2_Missense_Mutation_p.R1717W|PTPRD_uc003zkn.2_Missense_Mutation_p.R1319W|PTPRD_uc003zko.2_Missense_Mutation_p.R1320W	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1730	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CAGAGCATCCGCCAGAAGTCT	0.473			NA								TSP Lung(15;0.13)			5	33					0	0	0.000602	0	0
INVS	27130	broad.mit.edu	37	9	102888823	102888823	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:102888823G>T	uc004bap.1	+	3	477	c.265G>T	c.(265-267)GCC>TCC	p.A89S	INVS_uc010mta.1_5'UTR|INVS_uc011lve.1_5'UTR|INVS_uc004bao.1_Missense_Mutation_p.A89S|INVS_uc004baq.1_5'UTR|INVS_uc004bar.1_5'UTR|INVS_uc010mtb.1_5'UTR	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	89	ANK 3.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				CCATCTTGCAGCCCAGAAGGT	0.428			NA											17	45					7.45023e-12	1.01247e-11	0.010504	1	0
C9orf91	203197	broad.mit.edu	37	9	117400932	117400932	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:117400932G>T	uc004bjd.3	+	8	992	c.775G>T	c.(775-777)GGC>TGC	p.G259C	C9orf91_uc004bje.3_Missense_Mutation_p.G238C|C9orf91_uc004bjf.3_Missense_Mutation_p.G158C	NM_153045	NP_694590	Q5VZI3	CI091_HUMAN	hypothetical protein LOC203197	259						integral to membrane				pancreas(1)	1						TCTCCTGCCCGGCAATTCTTG	0.577			NA											5	61					5.9392e-07	6.95641e-07	0.001168	1	0
INPP5E	56623	broad.mit.edu	37	9	139327515	139327515	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:139327515G>C	uc004cho.2	-	5	1557	c.1172C>G	c.(1171-1173)TCC>TGC	p.S391C	INPP5E_uc010nbm.2_Missense_Mutation_p.S391C	NM_019892	NP_063945	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase E	391						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			skin(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GGTCACCGTGGAGCACTCCAC	0.632			NA											17	33					0	0	0.008871	0	0
MXRA5	25878	broad.mit.edu	37	X	3228353	3228353	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:3228353G>T	uc004crg.3	-	7	8048	c.7891C>A	c.(7891-7893)CTG>ATG	p.L2631M		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2631						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCCACCTTCAGGGAGACCAGC	0.622			NA											14	36					1.5739e-10	2.05967e-10	0.004007	1	0
MXRA5	25878	broad.mit.edu	37	X	3238388	3238388	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:3238388G>A	uc004crg.3	-	5	5495	c.5338C>T	c.(5338-5340)CTG>TTG	p.L1780L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1780						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCAAAGTCCAGATGGAAGGTG	0.522			NA											11	33					0	0	0.001855	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069327	6069327	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:6069327G>T	uc010ndh.2	-	2	682	c.181C>A	c.(181-183)CCG>ACG	p.P61T	NLGN4X_uc004crp.2_Missense_Mutation_p.P61T|NLGN4X_uc004crq.2_Missense_Mutation_p.P61T|NLGN4X_uc010ndi.2_Missense_Mutation_p.P61T|NLGN4X_uc004crr.2_Missense_Mutation_p.P61T|NLGN4X_uc010ndj.2_Missense_Mutation_p.P61T	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	61	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TTGGGTAACGGTGTTCTTAGG	0.537			NA											7	92					2.0095e-06	2.34073e-06	0.001984	1	0
SYTL5	94122	broad.mit.edu	37	X	37969597	37969597	+	Silent	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:37969597G>A	uc004ddu.2	+	14	1992	c.1458G>A	c.(1456-1458)CTG>CTA	p.L486L	SYTL5_uc004ddv.2_Silent_p.L486L|SYTL5_uc004ddx.2_Silent_p.L508L	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	486	C2 1.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						ATACCCAGCTGGAAACAAGAA	0.453			NA											13	62					0	0	0.001855	0	0
DUSP21	63904	broad.mit.edu	37	X	44703617	44703617	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:44703617G>A	uc004dgd.2	+	1	369	c.239G>A	c.(238-240)CGT>CAT	p.R80H		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	80	Tyrosine-protein phosphatase.|Sufficient for mitochondrial localization (By similarity).					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						CGTGACTCGCGTCTCTACGAC	0.537			NA											15	124					0	0	0.00499	0	0
PHF16	9767	broad.mit.edu	37	X	46913915	46913915	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:46913915A>G	uc004dgx.2	+	9	1379	c.1328A>G	c.(1327-1329)AAT>AGT	p.N443S	PHF16_uc004dgy.2_Missense_Mutation_p.N443S	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	443					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						AGTAACTTCAATAAGCCATTA	0.453			NA											11	39					0	0	0.008291	0	0
GATA1	2623	broad.mit.edu	37	X	48652249	48652249	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:48652249G>T	uc004dkq.3	+	6	1011	c.920G>T	c.(919-921)CGC>CTC	p.R307L		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	307					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						ACTCGAAACCGCAAGGCATCT	0.587	Pancreas(9;429 505 11287 29617)		NA	Mis|F		megakaryoblastic leukemia of Downs Syndrome								3	13					0.00024832	0.000277073	0.009096	1	0
OPHN1	4983	broad.mit.edu	37	X	67426434	67426434	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:67426434T>A	uc004dww.3	-	10	1208	c.914A>T	c.(913-915)CAG>CTG	p.Q305L	OPHN1_uc011mpg.1_Missense_Mutation_p.Q305L	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	305	PH.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						ACCTGGCTTCTGCTCCATAGG	0.408			NA											17	40					0	0	0.00499	0	0
TEX11	56159	broad.mit.edu	37	X	69825332	69825332	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:69825332C>A	uc004dyl.2	-	25	2193	c.2031G>T	c.(2029-2031)CTG>CTT	p.L677L	TEX11_uc004dyk.2_Silent_p.L352L|TEX11_uc004dym.2_Silent_p.L662L	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	677							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TCCGTGCAATCAGAATTACTT	0.388			NA											8	58					0.00307968	0.00334816	0.00308	1	0
ATP7A	538	broad.mit.edu	37	X	77298834	77298834	+	Missense_Mutation	SNP	T	T	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:77298834T>G	uc004ecx.3	+	21	4185	c.4025T>G	c.(4024-4026)GTG>GGG	p.V1342G		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1342	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						CTGGATGTAGTGGCAAGTATT	0.338			NA											6	110					0	0	0.00308	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133872	91133872	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:91133872C>A	uc004efk.1	+	2	3478	c.2633C>A	c.(2632-2634)CCT>CAT	p.P878H	PCDH11X_uc004efl.1_Missense_Mutation_p.P878H|PCDH11X_uc004efo.1_Missense_Mutation_p.P878H|PCDH11X_uc010nmv.1_Missense_Mutation_p.P878H|PCDH11X_uc004efm.1_Missense_Mutation_p.P878H|PCDH11X_uc004efn.1_Missense_Mutation_p.P878H|PCDH11X_uc004efh.1_Missense_Mutation_p.P878H|PCDH11X_uc004efj.1_Missense_Mutation_p.P878H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	878	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						aagCATTCCCCTAAGAACTTG	0.353	NSCLC(38;925 1092 2571 38200 45895)		NA											14	35					1.05317e-09	1.35316e-09	0.00245	1	0
GPRASP1	9737	broad.mit.edu	37	X	101912229	101912229	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:101912229A>G	uc004ejj.3	+	5	4189	c.3388A>G	c.(3388-3390)AGG>GGG	p.R1130G	GPRASP1_uc004eji.3_Missense_Mutation_p.R1130G|GPRASP1_uc010nod.2_Missense_Mutation_p.R1130G	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1130	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AGAGCATCTTAGGGCCAAGGA	0.433			NA											7	112					0	0	0.00308	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117960320	117960320	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:117960320G>T	uc004equ.2	+	4	1586	c.1113G>T	c.(1111-1113)GAG>GAT	p.E371D		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						AGGTTTTTGAGAATTTGATCA	0.498			NA											11	49					0.000673444	0.000739742	0.008291	1	0
SH2D1A	4068	broad.mit.edu	37	X	123480601	123480601	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:123480601G>T	uc004euf.3	+	1	454	c.109G>T	c.(109-111)GTG>TTG	p.V37L	SH2D1A_uc004euh.3_Missense_Mutation_p.V37L|SH2D1A_uc004eug.3_RNA|SH2D1A_uc010nqw.2_RNA|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	37	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						CAGCGAGAGCGTGCCAGGCGT	0.602			NA							X-linked_Lymphoproliferative_syndrome				11	97					6.40141e-05	7.25721e-05	0.010729	1	0
FMR1	2332	broad.mit.edu	37	X	147027066	147027066	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:147027066A>T	uc010nst.2	+	16	1856	c.1667A>T	c.(1666-1668)CAC>CTC	p.H556L	FMR1_uc004fcj.2_Missense_Mutation_p.H533L|FMR1_uc004fck.3_Missense_Mutation_p.H510L|FMR1_uc004fcl.3_Missense_Mutation_p.H396L|FMR1_uc011mxa.1_Missense_Mutation_p.H203L	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	556	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AACGACGATCACTCCCGAACA	0.398			NA							Fragile_X_syndrome				10	31					0	0	0.010729	0	0
FMR1NB	158521	broad.mit.edu	37	X	147084782	147084782	+	Silent	SNP	C	C	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:147084782C>A	uc004fcm.2	+	2	413	c.339C>A	c.(337-339)GGC>GGA	p.G113G		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	113	Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCTCATGGCCAATCTCTGG	0.363			NA											25	75					2.48779e-11	3.31706e-11	0.005443	1	0
MAGEA11	4110	broad.mit.edu	37	X	148798206	148798206	+	Nonsense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:148798206G>T	uc004fdq.2	+	5	1162	c.1060G>T	c.(1060-1062)GAG>TAG	p.E354*	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Nonsense_Mutation_p.E325*	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	354	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCTCTTTGGGGAGCCCAAGAG	0.542			NA											46	189					1.07234e-20	1.67159e-20	0.01441	1	0
MAMLD1	10046	broad.mit.edu	37	X	149631068	149631068	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:149631068G>T	uc004fee.1	+	2	203	c.127G>T	c.(127-129)GAT>TAT	p.D43Y	MAMLD1_uc011mxt.1_Missense_Mutation_p.D5Y|MAMLD1_uc011mxu.1_Intron|MAMLD1_uc011mxv.1_Intron	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	43					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGGAAGAAGATTTATCTTT	0.413			NA											12	46					1.45105e-14	2.09267e-14	0.006122	1	0
AVPR2	554	broad.mit.edu	37	X	153172004	153172004	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:153172004T>A	uc004fjh.3	+	3	1009	c.938T>A	c.(937-939)CTG>CAG	p.L313Q	AVPR2_uc004fjg.3_Missense_Mutation_p.L102Q|AVPR2_uc004fji.2_3'UTR	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	313	Helical; Name=7; (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTCATGTTGCTGGCCAGCCTC	0.617			NA											58	244					0	0	0.01441	0	0
FLNA	2316	broad.mit.edu	37	X	153588368	153588368	+	Silent	SNP	A	A	G			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:153588368A>G	uc004fkk.2	-	22	4044	c.3795T>C	c.(3793-3795)ATT>ATC	p.I1265I	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Silent_p.I1265I	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1265	Filamin 11.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGGCCCTCAATACCAGGCC	0.642			NA											7	60					0	0	0.00308	0	0
OR2M3	127062	broad.mit.edu	37	1	248366489	248366489	+	Frame_Shift_Del	DEL	G	G	-	rs143468114		TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr1:248366489delG	uc010pzg.1	+	1	120	c.120delG	c.(118-120)ATGfs	p.M40fs		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGCCTTCATGGGAAACTCTG	0.542			NA											53	326	---	---	---	---	NA	NA	NA	NA	NA
CNTF	1270	broad.mit.edu	37	11	58391793	58391794	+	Frame_Shift_Ins	INS	-	-	C			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:58391793_58391794insC	uc001nna.3	+	2	481_482	c.401_402insC	c.(400-402)ATCfs	p.I134fs	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	134					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GAATACAAGATCCCCCGCAATG	0.48			NA											12	44	---	---	---	---	NA	NA	NA	NA	NA
ATM	472	broad.mit.edu	37	11	108128207	108128208	+	Splice_Site	INS	-	-	T			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr11:108128207_108128208insT	uc001pkb.1	+	15	2636	c.2251_splice	c.e15-1	p.S751_splice	ATM_uc009yxr.1_Splice_Site_p.S751_splice	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATTCACAATAGTCTCTAATGCA	0.297			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			7	41	---	---	---	---	NA	NA	NA	NA	NA
TBX3	6926	broad.mit.edu	37	12	115118942	115118942	+	Frame_Shift_Del	DEL	A	A	-			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr12:115118942delA	uc001tvt.1	-	2	1363	c.399delT	c.(397-399)TTTfs	p.F133fs	TBX3_uc001tvu.1_Frame_Shift_Del_p.F133fs|TBX3_uc010syw.1_Frame_Shift_Del_p.F133fs	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	133	T-box; first part.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TAAATGGAGGAAACATTCGCC	0.328			NA											14	101	---	---	---	---	NA	NA	NA	NA	NA
AATF	26574	broad.mit.edu	37	17	35378272	35378273	+	Frame_Shift_Ins	INS	-	-	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr17:35378272_35378273insA	uc002hni.2	+	10	1757_1758	c.1506_1507insA	c.(1504-1509)CACAAAfs	p.H502fs	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	502_503					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				GCAAAATCCACAAAAAAGTAGA	0.361	NSCLC(49;901 1159 19183 41572 46244)		NA											15	20	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1207090	1207091	+	Frame_Shift_Ins	INS	-	-	A			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr19:1207090_1207091insA	uc002lrl.1	+	1	1293_1294	c.178_179insA	c.(178-180)TACfs	p.Y60fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	60	ATP (By similarity).|Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(3)|p.Y60fs*1(3)|p.Y60*(2)|p.G56fs*4(1)|p.G52_P179del(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGGCTCTTACGGCAAGGTG	0.629			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			19	27	---	---	---	---	NA	NA	NA	NA	NA
ARL4A	10124	broad.mit.edu	37	7	12727948	12727976	+	Frame_Shift_Del	DEL	TGTTATTCTGGGTTTGGACTGTGCTGGAA	TGTTATTCTGGGTTTGGACTGTGCTGGAA	-	rs144595174	byFrequency	TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	TGTTATTCTGGGTTTGGACTGTGCTGGAA	TGTTATTCTGGGTTTGGACTGTGCTGGAA	-	-	TGTTATTCTGGGTTTGGACTGTGCTGGAA	TGTTATTCTGGGTTTGGACTGTGCTGGAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr7:12727948_12727976delTGTTATTCTGGGTTTGGACTGTGCTGGAA	uc003ssp.2	+	2	346_374	c.69_97delTGTTATTCTGGGTTTGGACTGTGCTGGAA	c.(67-99)ATTGTTATTCTGGGTTTGGACTGTGCTGGAAAGfs	p.I23fs	ARL4A_uc003ssq.2_Frame_Shift_Del_p.I23fs|ARL4A_uc003ssr.2_Frame_Shift_Del_p.I23fs|ARL4A_uc003sss.2_Frame_Shift_Del_p.I23fs	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	23_33	GTP (By similarity).				small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		CTTTCCACATTGTTATTCTGGGTTTGGACTGTGCTGGAAAGACAACTGT	0.406			NA											7	83	---	---	---	---	NA	NA	NA	NA	NA
DOCK8	81704	broad.mit.edu	37	9	420560	420561	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:420560_420561delTG	uc003zgf.2	+	31	4112_4113	c.4000_4001delTG	c.(4000-4002)TGTfs	p.C1334fs	DOCK8_uc010mgu.2_Frame_Shift_Del_p.C636fs|DOCK8_uc010mgv.2_Frame_Shift_Del_p.C1234fs|DOCK8_uc003zgk.2_Frame_Shift_Del_p.C792fs	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1334	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ACTTTTCATCTGTGTGTTATGT	0.411			NA											8	110	---	---	---	---	NA	NA	NA	NA	NA
ADAMTSL1	92949	broad.mit.edu	37	9	18533290	18533290	+	Frame_Shift_Del	DEL	G	G	-			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chr9:18533290delG	uc003zne.3	+	3	364	c.237delG	c.(235-237)GTGfs	p.V79fs	ADAMTSL1_uc003znb.2_Frame_Shift_Del_p.V79fs|ADAMTSL1_uc003znc.3_Frame_Shift_Del_p.V79fs	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	79	TSP type-1 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GCAGTAATGTGGTAAGTATAA	0.333			NA											16	45	---	---	---	---	NA	NA	NA	NA	NA
FOXO4	4303	broad.mit.edu	37	X	70320642	70320642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:70320642delG	uc004dys.1	+	2	915	c.562delG	c.(562-564)GGCfs	p.G188fs	FOXO4_uc010nkz.2_Frame_Shift_Del_p.G188fs|FOXO4_uc004dyt.1_Frame_Shift_Del_p.G133fs	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	188	Fork-head.				cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)					AGGCAAGAGCGGCAAAgcccc	0.522			NA									OREG0019856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	25	---	---	---	---	NA	NA	NA	NA	NA
SLITRK2	84631	broad.mit.edu	37	X	144904859	144904859	+	Frame_Shift_Del	DEL	A	A	-			TCGA-53-7813-01A-11D-2167-08	TCGA-53-7813-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	70fe51ad-3d21-42f5-9ccf-1f8c37560f1b	3d0cb74b-6f66-41bc-8af3-29e99f78ae29	g.chrX:144904859delA	uc004fcd.2	+	5	1906	c.916delA	c.(916-918)AAAfs	p.K306fs	SLITRK2_uc010nsp.2_Frame_Shift_Del_p.K306fs|SLITRK2_uc010nso.2_Frame_Shift_Del_p.K306fs|SLITRK2_uc011mwq.1_Frame_Shift_Del_p.K306fs|SLITRK2_uc011mwr.1_Frame_Shift_Del_p.K306fs|SLITRK2_uc011mws.1_Frame_Shift_Del_p.K306fs|SLITRK2_uc004fcg.2_Frame_Shift_Del_p.K306fs|SLITRK2_uc011mwt.1_Frame_Shift_Del_p.K306fs	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	306	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCGGCCGCCCAAAATGAGAAA	0.552			NA											18	69	---	---	---	---	NA	NA	NA	NA	NA
