Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TARDBP	23435	broad.mit.edu	37	1	11082410	11082410	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:11082410C>T	uc001art.2	+	6	1078	c.944C>T	c.(943-945)GCG>GTG	p.A315V	TARDBP_uc010oap.1_Missense_Mutation_p.A199V	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	315	Gly-rich.		A -> T (in ALS10).		3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AACTTTGGTGCGTTCAGCATT	0.532			NA											5	82					0	0	0.000602	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884933	12884933	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:12884933T>C	uc001auk.2	-	4	1374	c.1178A>G	c.(1177-1179)CAA>CGA	p.Q393R		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	393											0						AGCCCTAATTTGAGCAAATCT	0.488			NA											30	317					0	0	0.00632	0	0
WLS	79971	broad.mit.edu	37	1	68603589	68603589	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:68603589C>A	uc001def.1	-	11	1661	c.1390G>T	c.(1390-1392)GGC>TGC	p.G464C	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.G462C|WLS_uc001deg.1_Missense_Mutation_p.G373C|WLS_uc009wbf.1_Missense_Mutation_p.G419C	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	464	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						ACTGTGACGCCGCCCCATTTC	0.438			NA											12	53					2.27111e-07	3.07699e-07	0.001368	1	0
C1orf173	127254	broad.mit.edu	37	1	75038965	75038965	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:75038965C>A	uc001dgg.2	-	14	2648	c.2429G>T	c.(2428-2430)AGG>ATG	p.R810M		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	810	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTTCCACGCCCTCAAGGGAGC	0.557			NA											15	89					0.000308642	0.000367744	0.003163	1	0
GBP3	2635	broad.mit.edu	37	1	89480335	89480335	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:89480335T>A	uc001dmt.2	-	4	528	c.323A>T	c.(322-324)GAC>GTC	p.D108V	GBP3_uc010oss.1_Missense_Mutation_p.D29V|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	108						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		ATTCTGGTTGTCACCCTGGAA	0.473			NA											25	61					0	0	0.008361	0	0
RBM15	64783	broad.mit.edu	37	1	110882201	110882201	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:110882201C>T	uc001dzl.1	+	1	257	c.174C>T	c.(172-174)TCC>TCT	p.S58S	RBM15_uc001dzm.1_Silent_p.S58S|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	58					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCAAACGCTCCCGTGGTGGTG	0.652			NA	T	MKL1	acute megakaryocytic leukemia								11	48					0	0	0.000978	0	0
GJA5	2702	broad.mit.edu	37	1	147230940	147230940	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:147230940C>T	uc001eps.1	-	2	548	c.407G>A	c.(406-408)TGG>TAG	p.W136*	GJA5_uc001ept.1_Nonsense_Mutation_p.W136*	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	136	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CCCTTCCTCCCAGCAGGACAG	0.602			NA											8	138					0	0	0.004482	0	0
ECM1	1893	broad.mit.edu	37	1	150485219	150485219	+	Silent	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:150485219G>C	uc001eus.2	+	9	1522	c.1323G>C	c.(1321-1323)CTG>CTC	p.L441L	ECM1_uc001eut.2_Silent_p.L316L|ECM1_uc001euu.2_Silent_p.L470L|ECM1_uc001euv.2_Silent_p.L468L|ECM1_uc009wlu.2_Silent_p.L201L	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	441					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TTCCTGGGCTGATCCACAACA	0.522	Melanoma(156;1696 2560 11093 19685)		NA											26	310					0	0	0.001786	0	0
PBXIP1	57326	broad.mit.edu	37	1	154919123	154919124	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:154919123_154919124CC>TA	uc001ffr.2	-	10	1085_1086	c.1026_1027GG>TA	c.(1024-1029)GAGGCC>GATACC	p.342_343EA>DT	PBXIP1_uc001ffs.2_Missense_Mutation_p.313_314EA>DT|PBXIP1_uc010pep.1_Missense_Mutation_p.187_188EA>DT	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	342_343	Potential.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACACAGTCGGCCTCCAGCCCCT	0.703			NA											12	21					0	0	0.004672	0	0
PEAR1	375033	broad.mit.edu	37	1	156882331	156882331	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:156882331A>T	uc001fqj.1	+	17	2242	c.2126A>T	c.(2125-2127)CAG>CTG	p.Q709L	PEAR1_uc001fqk.1_Missense_Mutation_p.Q334L	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	709						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGCCATGCCAGTGTGGTCCT	0.607			NA											19	66					0	0	0.007413	0	0
SPTA1	6708	broad.mit.edu	37	1	158609780	158609781	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:158609780_158609781CA>AG	uc001fst.1	-	34	4953_4954	c.4754_4755TG>CT	c.(4753-4755)CTG>CCT	p.L1585P		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1585	Spectrin 15.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AATGTTCCTTCAGCTGTTCCAG	0.48			NA											23	104					0	0	0.004672	0	0
ZP4	57829	broad.mit.edu	37	1	238048857	238048857	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:238048857C>A	uc001hym.2	-	8	994	c.994G>T	c.(994-996)GGT>TGT	p.G332C	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	332	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCACCAACACCGTAGTAAGAG	0.483	NSCLC(166;160 2029 11600 18754 19936)		NA											10	58					0.000442599	0.000523639	0.006214	1	0
OR2T33	391195	broad.mit.edu	37	1	248436327	248436327	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr1:248436327T>C	uc010pzi.1	-	1	790	c.790A>G	c.(790-792)AGG>GGG	p.R264G		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTAGTGGACCTATGGGATTTG	0.483			NA											41	161					0	0	0.00874	0	0
GPR158	57512	broad.mit.edu	37	10	25861630	25861630	+	Missense_Mutation	SNP	G	G	T	rs138045559		TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr10:25861630G>T	uc001isj.2	+	7	1627	c.1567G>T	c.(1567-1569)GGC>TGC	p.G523C		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	523	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ATATATGACTGGCGGACGGGT	0.418			NA											13	69					0.000219431	0.000267134	0.00245	1	0
ZNF248	57209	broad.mit.edu	37	10	38121171	38121171	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr10:38121171C>A	uc001izd.1	-	6	1611	c.1112G>T	c.(1111-1113)CGG>CTG	p.R371L	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.R371L	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGAGCTCTCCGAAGCTGGGT	0.418			NA											15	92					3.52763e-06	4.59412e-06	0.00499	1	0
CDH23	64072	broad.mit.edu	37	10	73569756	73569756	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr10:73569756G>A	uc001jrx.3	+	59	9279	c.8902G>A	c.(8902-8904)GTG>ATG	p.V2968M	CDH23_uc001jsg.3_Missense_Mutation_p.V728M|CDH23_uc001jsh.3_Missense_Mutation_p.V728M|CDH23_uc001jsi.3_Missense_Mutation_p.V728M|CDH23_uc001jsj.3_5'Flank|CDH23_uc010qjr.1_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2968	Cadherin 27.|Extracellular (Potential).		V -> A (in USH1D).		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCCCGACCGTGTGCGCGGCTT	0.602			NA											21	106					0	0	0.00278	0	0
MYOF	26509	broad.mit.edu	37	10	95216684	95216684	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr10:95216684C>A	uc001kin.2	-	2	222	c.99G>T	c.(97-99)AAG>AAT	p.K33N	MYOF_uc001kio.2_Missense_Mutation_p.K33N|MYOF_uc001kip.3_Missense_Mutation_p.K33N|MYOF_uc009xuf.2_Missense_Mutation_p.K15N	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	33	C2 1.|Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TCTTTGTTTTCTTTTTCTCAT	0.313			NA											5	46					1.23904e-05	1.589e-05	0.000602	1	0
IKZF5	64376	broad.mit.edu	37	10	124753508	124753508	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr10:124753508T>G	uc001lha.2	-	5	1347	c.1048A>C	c.(1048-1050)ACC>CCC	p.T350P	IKZF5_uc001lgz.2_Missense_Mutation_p.T188P	NM_022466	NP_071911	Q9H5V7	IKZF5_HUMAN	zinc finger protein, subfamily 1A, 5	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		GGGGCTGGGGTGCTTGGCTGG	0.547			NA											10	63					0	0	0.001786	0	0
MUC5B	727897	broad.mit.edu	37	11	1264070	1264070	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:1264070C>T	uc009ycr.1	+	47	8165	c.8039C>T	c.(8038-8040)TCC>TTC	p.S2680F	MUC5B_uc001ltb.2_Missense_Mutation_p.S1990F	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1987	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCTCTTCCTCCCTGGGCACC	0.637			NA											45	197					0	0	0.00361	0	0
OR52R1	119695	broad.mit.edu	37	11	4824767	4824767	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:4824767G>C	uc010qym.1	-	1	1081	c.1081C>G	c.(1081-1083)CTC>GTC	p.L361V		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTAGATAGAGATTAGCAAAC	0.468			NA											34	130					0	0	0.002445	0	0
USH1C	10083	broad.mit.edu	37	11	17542494	17542494	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:17542494C>T	uc001mnf.2	-	14	1242	c.1133G>A	c.(1132-1134)TGG>TAG	p.W378*	USH1C_uc001mne.2_Nonsense_Mutation_p.W378*|USH1C_uc009yhb.2_Nonsense_Mutation_p.W359*|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Nonsense_Mutation_p.W342*	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	378					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CTTTGAGCCCCAGTCTTCTTC	0.498			NA											105	448					0	0	0.00361	0	0
WT1	7490	broad.mit.edu	37	11	32413568	32413568	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:32413568G>T	uc001mtn.1	-	9	1578	c.1382C>A	c.(1381-1383)TCC>TAC	p.S461Y	WT1_uc001mtl.1_Missense_Mutation_p.S249Y|WT1_uc001mtm.1_Missense_Mutation_p.S232Y|WT1_uc001mto.1_Missense_Mutation_p.S461Y|WT1_uc001mtp.1_Missense_Mutation_p.S444Y|WT1_uc001mtq.1_Missense_Mutation_p.S444Y|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	393	C2H2-type 3.|Important for interaction with target DNA.				adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GTCGGACCGGGAGAACTTTCG	0.433			NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				28	162					9.45814e-24	1.49903e-23	0.004878	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735552	55735552	+	Missense_Mutation	SNP	T	T	G	rs140763949		TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:55735552T>G	uc010rit.1	-	1	388	c.388A>C	c.(388-390)AAA>CAA	p.K130Q		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					ATGCAGACTTTGTGGTTCATC	0.453			NA											7	33					0	0	0.008291	0	0
OR4D10	390197	broad.mit.edu	37	11	59245081	59245081	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:59245081A>G	uc001nnz.1	+	1	179	c.179A>G	c.(178-180)TAT>TGT	p.Y60C		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ACGCCCATGTATTTTTTGCTC	0.438			NA											16	188					0	0	0.003163	0	0
B3GAT1	27087	broad.mit.edu	37	11	134251867	134251867	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr11:134251867T>A	uc001qhq.2	-	6	1231	c.970A>T	c.(970-972)AAG>TAG	p.K324*	B3GAT1_uc001qhr.2_Nonsense_Mutation_p.K324*|B3GAT1_uc010scv.1_Nonsense_Mutation_p.K337*	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	324	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		AAGCCCTTCTTGCCCTCATTC	0.607			NA											6	70					0	0	0.001168	0	0
NCAPD2	9918	broad.mit.edu	37	12	6619879	6619879	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:6619879C>T	uc001qoo.2	+	5	393	c.347C>T	c.(346-348)GCC>GTC	p.A116V	NCAPD2_uc009zen.1_Intron|NCAPD2_uc010sfd.1_Missense_Mutation_p.A71V	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	116	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						CATCTAAATGCCCTCAAAATG	0.502			NA											5	104					0	0	0.001168	0	0
CD163	9332	broad.mit.edu	37	12	7649703	7649703	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:7649703C>T	uc001qsz.3	-	5	933	c.805G>A	c.(805-807)GTA>ATA	p.V269I	CD163_uc001qta.3_Missense_Mutation_p.V269I|CD163_uc009zfw.2_Missense_Mutation_p.V269I	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	269	SRCR 3.|Extracellular (Potential).	Cleavage; in calcium-free condition.			acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ACTCCATCTACCAGTCTCAGG	0.458			NA											9	86					0	0	0.006214	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	10					3.59834e-05	4.47793e-05	0.001168	1	0
KRT7	3855	broad.mit.edu	37	12	52629142	52629142	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:52629142C>A	uc001saa.1	+	2	655	c.528C>A	c.(526-528)TTC>TTA	p.F176L	KRT7_uc009zmf.1_Missense_Mutation_p.F176L	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	176	Rod.|Coil 1B.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TGGAGGACTTCAAGAATAAGT	0.622			NA											10	36					0.000673444	0.000785685	0.008291	1	0
NXPH4	11247	broad.mit.edu	37	12	57619307	57619307	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:57619307T>A	uc010srf.1	+	2	879	c.704T>A	c.(703-705)GTG>GAG	p.V235E	NXPH4_uc009zpj.2_Missense_Mutation_p.V41E	NM_007224	NP_009155	O95158	NXPH4_HUMAN	neurexophilin 4 precursor	235	V (Cys-rich).				neuropeptide signaling pathway	extracellular region					0						AATTGCCACGTGGAGTATGAG	0.692			NA											4	26					0	0	0.000248	0	0
UBE3B	89910	broad.mit.edu	37	12	109936113	109936113	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:109936113G>A	uc001top.2	+	11	1498	c.895G>A	c.(895-897)GAT>AAT	p.D299N	UBE3B_uc001toq.2_Missense_Mutation_p.D299N|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.D299N	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	299					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TCGATGCCGTGATGTATGTGA	0.438			NA											23	141					0	0	0.003954	0	0
NAA25	80018	broad.mit.edu	37	12	112471045	112471045	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:112471045G>A	uc001ttm.2	-	23	2808	c.2788C>T	c.(2788-2790)CTC>TTC	p.L930F	NAA25_uc001ttn.3_RNA	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	930						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ACCGGTGAGAGAGAAGTGTCT	0.368			NA											16	66					0	0	0.00499	0	0
RASAL1	8437	broad.mit.edu	37	12	113553497	113553497	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr12:113553497G>A	uc001tum.1	-	11	1239	c.946C>T	c.(946-948)CGG>TGG	p.R316W	RASAL1_uc010syp.1_Missense_Mutation_p.R316W|RASAL1_uc001tul.2_Missense_Mutation_p.R316W|RASAL1_uc001tun.1_Missense_Mutation_p.R316W|RASAL1_uc010syq.1_Missense_Mutation_p.R316W|RASAL1_uc001tuo.3_Missense_Mutation_p.R316W|RASAL1_uc010syr.1_Missense_Mutation_p.R316W	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	316	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						GCCAGTCCCCGGCCAAGAAAG	0.627			NA											7	49					0	0	0.00308	0	0
GPR180	160897	broad.mit.edu	37	13	95273342	95273342	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr13:95273342C>T	uc001vly.2	+	6	825	c.747C>T	c.(745-747)ATC>ATT	p.I249I	GPR180_uc001vlz.2_Silent_p.I148I|GPR180_uc010afi.2_Silent_p.I10I	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	249	Helical; (Potential).					integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TTTTTGACATCGCTTCCCAAA	0.343			NA											4	62					0	0	0.000248	0	0
OR4M1	441670	broad.mit.edu	37	14	20248875	20248875	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr14:20248875T>A	uc010tku.1	+	1	394	c.394T>A	c.(394-396)TAT>AAT	p.Y132N		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ACCCCTCCACTATGCTACCAT	0.507			NA											20	410					0	0	0.002299	0	0
NID2	22795	broad.mit.edu	37	14	52505627	52505627	+	Missense_Mutation	SNP	G	G	A	rs148168699	byFrequency	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr14:52505627G>A	uc001wzo.2	-	9	2329	c.2095C>T	c.(2095-2097)CGC>TGC	p.R699C	NID2_uc010tqs.1_Missense_Mutation_p.R699C|NID2_uc010tqt.1_Missense_Mutation_p.R699C|NID2_uc001wzp.2_Missense_Mutation_p.R699C	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	699	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TGGTGGATGCGGTAGGACCAT	0.512			NA											6	91					0	0	0.001168	0	0
PELI2	57161	broad.mit.edu	37	14	56755184	56755184	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr14:56755184C>G	uc001xch.2	+	4	625	c.339C>G	c.(337-339)GAC>GAG	p.D113E		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	113					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						GCCCTATCGACTTCGTTGTCA	0.478			NA											10	31					0	0	0.000978	0	0
C15orf2	23742	broad.mit.edu	37	15	24922305	24922305	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr15:24922305G>T	uc001ywo.2	+	1	1765	c.1291G>T	c.(1291-1293)GAC>TAC	p.D431Y		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	431	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGACTTGGCTGACCTGGCTAC	0.542			NA											7	62					0.00198382	0.0022519	0.001984	1	0
CSPG4	1464	broad.mit.edu	37	15	75981484	75981484	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr15:75981484C>A	uc002baw.2	-	3	2015	c.1922G>T	c.(1921-1923)CGG>CTG	p.R641L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	641	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|CSPG 2.|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						ATCGCTGACCCGGAACGTCAA	0.687			NA											7	52					6.5536e-12	9.74341e-12	0.00308	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651344	84651344	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr15:84651344G>C	uc002bjz.3	+	21	3188	c.2964G>C	c.(2962-2964)CAG>CAC	p.Q988H	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.Q988H|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.Q988H	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	988	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCTCTGCACAGGAAACAGTTG	0.567			NA											38	85					0	0	0.007835	0	0
SMG1	23049	broad.mit.edu	37	16	18866017	18866017	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr16:18866017C>T	uc002dfm.2	-	30	4807	c.4444G>A	c.(4444-4446)GAA>AAA	p.E1482K	SMG1_uc010bwb.2_Missense_Mutation_p.E1342K|SMG1_uc010bwa.2_Missense_Mutation_p.E213K	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1482	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ATATCAAGTTCGGGCCCCCAT	0.338			NA											8	56					0	0	0.00308	0	0
TNRC6A	27327	broad.mit.edu	37	16	24803129	24803129	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr16:24803129A>T	uc002dmm.2	+	6	3280	c.3166A>T	c.(3166-3168)AGT>TGT	p.S1056C	TNRC6A_uc010bxs.2_Missense_Mutation_p.S803C|TNRC6A_uc010vcc.1_Missense_Mutation_p.S803C|TNRC6A_uc002dmn.2_Missense_Mutation_p.S803C|TNRC6A_uc002dmo.2_Missense_Mutation_p.S803C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1056	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		AGAGGCAAGCAGTGGCTCTGG	0.408			NA											4	12					0	0	0.000602	0	0
KATNB1	10300	broad.mit.edu	37	16	57775655	57775655	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr16:57775655G>T	uc002eml.1	+	3	471	c.97G>T	c.(97-99)GGG>TGG	p.G33W		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	33	WD 1.|Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CAAAGCCTCCGGGCGGCTGCT	0.647			NA											9	40					0.000274275	0.000331498	0.004482	1	0
LOC283922	283922	broad.mit.edu	37	16	74366531	74366531	+	Missense_Mutation	SNP	A	A	C	rs3743922	by1000genomes	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr16:74366531A>C	uc002fcr.2	-	14	2183	c.837T>G	c.(835-837)AAT>AAG	p.N279K	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						CCCGGATCCCATTTGCATAGC	0.502			NA											6	17					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	16	90161578	90161578	+	Silent	SNP	G	G	A	rs13337896	by1000genomes	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr16:90161578G>A	uc002fqp.2	+	3	931	c.453G>A	c.(451-453)ACG>ACA	p.T151T	uc002fqq.2_Silent_p.T168T					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.												NA						GCCAAGGGACGCTACACCGAA	0.587			NA											4	69					0	0	0.000248	0	0
ZBTB4	57659	broad.mit.edu	37	17	7365687	7365687	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:7365687C>A	uc002ghc.3	-	4	2864	c.2614G>T	c.(2614-2616)GTG>TTG	p.V872L	ZBTB4_uc002ghd.3_Missense_Mutation_p.V872L	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	872					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		AATTCCTGCACAGGTGGGTAT	0.627			NA											9	46					1.58986e-06	2.11982e-06	0.008291	1	0
CNTROB	116840	broad.mit.edu	37	17	7851025	7851025	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:7851025G>T	uc002gjq.2	+	15	3049	c.2130G>T	c.(2128-2130)AAG>AAT	p.K710N	CNTROB_uc002gjp.2_Missense_Mutation_p.K710N|CNTROB_uc002gjr.2_Missense_Mutation_p.K612N	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	710	Pro-rich.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				AGGGCCTCAAGAATTTTTTGC	0.542			NA											12	91					1.08611e-07	1.48346e-07	0.000978	1	0
TMEM132E	124842	broad.mit.edu	37	17	32961947	32961947	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:32961947C>T	uc002hif.2	+	8	1876	c.1548C>T	c.(1546-1548)TCC>TCT	p.S516S		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	516	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CGACATCATCCGAGGGCACTG	0.637			NA											8	85					0	0	0.008291	0	0
KRT40	125115	broad.mit.edu	37	17	39137108	39137108	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:39137108G>T	uc010cxh.1	-	7	1065	c.904C>A	c.(904-906)CAG>AAG	p.Q302K	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	302	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				ATCTCCATCTGGCAGCCCTGC	0.522			NA											17	136					2.5808e-16	3.97774e-16	0.006122	1	0
TTC25	83538	broad.mit.edu	37	17	40101407	40101407	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:40101407A>C	uc002hyj.3	+	8	1165	c.1076A>C	c.(1075-1077)AAA>ACA	p.K359T	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Missense_Mutation_p.N215H	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	359						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CCTGATGCAAAATCGAGAGCC	0.378			NA											3	14					0	0	0.004672	0	0
CNP	1267	broad.mit.edu	37	17	40120102	40120102	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:40120102G>A	uc002hyl.1	+	2	164	c.20G>A	c.(19-21)CGA>CAA	p.R7Q	CNP_uc002hyk.1_Missense_Mutation_p.R7Q|CNP_uc010wfz.1_Missense_Mutation_p.R7Q|CNP_uc002hym.1_5'UTR|CNP_uc010wga.1_Intron	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	7					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		GGCTTCTCCCGAAAAAGCCAC	0.567			NA											7	98					0	0	0.00308	0	0
TEX2	55852	broad.mit.edu	37	17	62238285	62238285	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:62238285T>A	uc002jec.2	-	8	2853	c.2680A>T	c.(2680-2682)ATT>TTT	p.I894F	TEX2_uc002jed.2_Missense_Mutation_p.I901F|TEX2_uc002jee.2_Missense_Mutation_p.I894F	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	894					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TCCAAATCAATCCAGAGTCCT	0.363			NA											18	97					0	0	0.00499	0	0
CCDC57	284001	broad.mit.edu	37	17	80059641	80059641	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:80059641T>C	uc002kdx.1	-	17	2702	c.2665A>G	c.(2665-2667)ACA>GCA	p.T889A		NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	890										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			GAGGCTCCTGTGGTCTTGGCC	0.612			NA											16	105					0	0	0.004007	0	0
CLUL1	27098	broad.mit.edu	37	18	641480	641480	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr18:641480G>T	uc002kkp.2	+	7	1293	c.1148G>T	c.(1147-1149)GGC>GTC	p.G383V	CLUL1_uc010wys.1_Missense_Mutation_p.G435V|CLUL1_uc002kkq.2_Missense_Mutation_p.G383V	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	383					cell death	extracellular region				ovary(2)	2						GGGCAATTTGGCTGGGTGTCT	0.493			NA											11	94					5.50884e-06	7.11911e-06	0.001368	1	0
LRRC30	339291	broad.mit.edu	37	18	7231146	7231146	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr18:7231146A>G	uc010wzk.1	+	1	10	c.10A>G	c.(10-12)AGG>GGG	p.R4G		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	4										ovary(1)|liver(1)	2						AATGGGGGCCAGGCAGTCAAG	0.607			NA											7	80					0	0	0.00308	0	0
POTEC	388468	broad.mit.edu	37	18	14542792	14542792	+	Silent	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr18:14542792G>T	uc010dln.2	-	1	808	c.354C>A	c.(352-354)GGC>GGA	p.G118G	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	118										skin(3)	3						CTCCCCAAGCGCCCACGTTGC	0.597			NA											14	200					1.05317e-09	1.52528e-09	0.00245	1	0
CDH7	1005	broad.mit.edu	37	18	63430252	63430252	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr18:63430252G>T	uc002ljz.2	+	2	499	c.174G>T	c.(172-174)GAG>GAT	p.E58D	CDH7_uc002lka.2_Missense_Mutation_p.E58D|CDH7_uc002lkb.2_Missense_Mutation_p.E58D	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	58	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TTGTGCTGGAGGAATACATGG	0.458			NA											12	48					4.36969e-10	6.38355e-10	0.001855	1	0
ADNP2	22850	broad.mit.edu	37	18	77896341	77896341	+	Silent	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr18:77896341G>C	uc002lnw.2	+	4	3500	c.3045G>C	c.(3043-3045)GTG>GTC	p.V1015V		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	1015					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CGAGTGTTGTGCCTTTTAAAA	0.507			NA											13	47					0	0	0.003163	0	0
PTPRS	5802	broad.mit.edu	37	19	5274329	5274329	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:5274329T>A	uc002mbv.2	-	3	352	c.118A>T	c.(118-120)AAG>TAG	p.K40*	PTPRS_uc002mbu.1_Nonsense_Mutation_p.K40*|PTPRS_uc010xin.1_Nonsense_Mutation_p.K40*|PTPRS_uc002mbw.2_Nonsense_Mutation_p.K40*|PTPRS_uc002mbx.2_Nonsense_Mutation_p.K40*|PTPRS_uc002mby.2_Nonsense_Mutation_p.K40*|PTPRS_uc002mbz.1_Nonsense_Mutation_p.K40*	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	40	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		ATCTGGTCCTTGGGTTCTTTG	0.597			NA											16	28					0	0	0.004007	0	0
MBD3L1	85509	broad.mit.edu	37	19	8953771	8953771	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:8953771C>T	uc002mko.2	+	1	503	c.417C>T	c.(415-417)ATC>ATT	p.I139I		NM_145208	NP_660209	Q8WWY6	MB3L1_HUMAN	methyl-CpG binding domain protein 3-like	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GAGTGGGTATCTCGCAGCTCC	0.522			NA											5	27					0	0	0.000602	0	0
KIAA1683	80726	broad.mit.edu	37	19	18375896	18375896	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:18375896C>T	uc002nin.2	-	3	2670	c.2454G>A	c.(2452-2454)CAG>CAA	p.Q818Q	KIAA1683_uc010ebn.2_Silent_p.Q818Q|KIAA1683_uc010xqe.1_Silent_p.Q772Q	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	818						mitochondrion				ovary(2)	2						ATGGTCCCCCCTGAGTGGTCT	0.687			NA											9	134					0	0	0.008291	0	0
ZNF420	147923	broad.mit.edu	37	19	37619025	37619025	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:37619025C>T	uc002ofl.2	+	5	1347	c.1132C>T	c.(1132-1134)CTT>TTT	p.L378F		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	378	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGCTCACAACTTACTCAACA	0.418			NA											8	83					0	0	0.004482	0	0
FCGBP	8857	broad.mit.edu	37	19	40411646	40411646	+	Nonsense_Mutation	SNP	T	T	A	rs139603547		TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:40411646T>A	uc002omp.3	-	7	3990	c.3982A>T	c.(3982-3984)AAG>TAG	p.K1328*		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1328	VWFD 3.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACCGTGACCTTCCACTGTCTC	0.647			NA											30	119					0	0	0.002836	0	0
PSG8	440533	broad.mit.edu	37	19	43258571	43258571	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:43258571G>T	uc002ouo.2	-	5	1255	c.1157C>A	c.(1156-1158)ACA>AAA	p.T386K	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.T225K|PSG8_uc002ouh.2_Missense_Mutation_p.T386K|PSG8_uc010ein.2_Missense_Mutation_p.T264K|PSG8_uc002ouj.3_Missense_Mutation_p.T168K|PSG8_uc002ouk.3_Missense_Mutation_p.T225K|PSG8_uc002oul.3_Missense_Mutation_p.T386K|PSG8_uc002oum.3_Missense_Mutation_p.T293K|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.T293K	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	386	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				GCTATGCTTTGTAGTAATTTG	0.468			NA											56	249					1.45723e-30	2.35398e-30	0.00361	1	0
KPTN	11133	broad.mit.edu	37	19	47986421	47986421	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:47986421G>C	uc002pgy.2	-	4	550	c.446C>G	c.(445-447)GCG>GGG	p.A149G	KPTN_uc010xys.1_RNA|uc002pgz.1_5'Flank	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	149					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		CACTCACTCCGCATGGCACAG	0.537			NA											43	230					0	0	0.00361	0	0
ZNF600	162966	broad.mit.edu	37	19	53268962	53268962	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:53268962G>C	uc002qab.3	-	3	2333	c.2047C>G	c.(2047-2049)CAA>GAA	p.Q683E		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	683	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CCAGTATGTTGTTTCAGGTGT	0.403	Esophageal Squamous(196;1235 2112 2375 33339 34207)		NA											13	63					0	0	0.001368	0	0
ZNF28	7576	broad.mit.edu	37	19	53303701	53303701	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:53303701G>T	uc002qad.2	-	4	1517	c.1397C>A	c.(1396-1398)CCA>CAA	p.P466Q	ZNF28_uc002qac.2_Missense_Mutation_p.P413Q|ZNF28_uc010eqe.2_Missense_Mutation_p.P412Q	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		ACATTTGTATGGTTTCTCTGC	0.388			NA											11	93					3.07112e-06	4.03084e-06	0.000978	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58565042	58565042	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:58565042C>T	uc002qrc.1	+	6	1097	c.850C>T	c.(850-852)CGT>TGT	p.R284C		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	284					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGTAGTGCCGCGTGGGCCCCG	0.627			NA											8	69					0	0	0.00308	0	0
RNF144A	9781	broad.mit.edu	37	2	7170334	7170334	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:7170334G>A	uc002qys.2	+	8	1177	c.735G>A	c.(733-735)TGG>TGA	p.W245*	RNF144A_uc002qyt.2_Nonsense_Mutation_p.W94*	NM_014746	NP_055561	P50876	R144A_HUMAN	ring finger protein 144	245						Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			ovary(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)		CTGTGATCTGGCATCGGACAC	0.423			NA											6	90					0	0	0.001984	0	0
KCNF1	3754	broad.mit.edu	37	2	11053812	11053812	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:11053812G>T	uc002rax.2	+	1	1750	c.1260G>T	c.(1258-1260)GAG>GAT	p.E420D		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	420	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GCGTCCTGGAGACCGCGGCCA	0.622			NA											4	40					0.000602214	0.000707497	0.000602	1	0
FSHR	2492	broad.mit.edu	37	2	49381520	49381520	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:49381520T>A	uc002rww.2	-	1	111	c.37A>T	c.(37-39)AGC>TGC	p.S13C	FSHR_uc002rwx.2_Missense_Mutation_p.S13C|FSHR_uc010fbn.2_Missense_Mutation_p.S13C|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	13				S -> R (in Ref. 8; CAA48179).	female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GAGCCCAAGCTCAGGAATGCC	0.498			NA							Gonadal_Dysgenesis_46_XX				19	37					0	0	0.007413	0	0
PLEK	5341	broad.mit.edu	37	2	68615552	68615552	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:68615552A>G	uc002sen.3	+	6	853	c.691A>G	c.(691-693)AGT>GGT	p.S231G	PLEK_uc010fde.2_Missense_Mutation_p.S231G	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	231					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGAGAATTCCAGTGATGATGA	0.458			NA											6	138					0	0	0.001984	0	0
POLR1A	25885	broad.mit.edu	37	2	86272749	86272749	+	Silent	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:86272749G>A	uc002sqs.2	-	20	3256	c.2877C>T	c.(2875-2877)ATC>ATT	p.I959I	POLR1A_uc010ytb.1_Silent_p.I325I|POLR1A_uc002sqt.1_5'Flank	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	959					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CAGGAGGTTTGATGCCGGTGA	0.507			NA											13	122					0	0	0.00245	0	0
ANKRD36	375248	broad.mit.edu	37	2	97779487	97779487	+	Missense_Mutation	SNP	G	G	A	rs141447363	by1000genomes	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:97779487G>A	uc010yva.1	+	1	255	c.11G>A	c.(10-12)GGC>GAC	p.G4D	ANKRD36_uc002sxn.2_Missense_Mutation_p.G4D|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.G4D|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	4											0						ATGGAAGACGGCAAGCGGGAG	0.562			NA											4	134					0	0	0.000248	0	0
MERTK	10461	broad.mit.edu	37	2	112754934	112754934	+	Silent	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:112754934G>T	uc002thk.1	+	10	1607	c.1485G>T	c.(1483-1485)GCG>GCT	p.A495A	MERTK_uc002thl.1_Silent_p.A319A	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	495	Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						CAACTCCGGCGCCTGGCAACG	0.448			NA											46	171					3.21987e-24	5.15179e-24	0.00361	1	0
YSK4	80122	broad.mit.edu	37	2	135744057	135744057	+	Silent	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:135744057G>A	uc002tue.1	-	7	2416	c.2385C>T	c.(2383-2385)TCC>TCT	p.S795S	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.S682S|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Silent_p.S523S|YSK4_uc002tui.3_Silent_p.S812S	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	795							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCTGTTTCATGGACTGCTCAG	0.388			NA											6	68					0	0	0.001168	0	0
THSD7B	80731	broad.mit.edu	37	2	137814267	137814267	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:137814267G>C	uc002tva.1	+	2	324	c.324G>C	c.(322-324)CAG>CAC	p.Q108H	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATGGACTGCAGCACCGGATGG	0.552			NA											15	93					0	0	0.003163	0	0
PPIG	9360	broad.mit.edu	37	2	170493582	170493582	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:170493582G>T	uc002uez.2	+	14	2034	c.1814G>T	c.(1813-1815)CGA>CTA	p.R605L	PPIG_uc010fpx.2_Missense_Mutation_p.R590L|PPIG_uc010fpy.2_Missense_Mutation_p.R598L|PPIG_uc002ufb.2_Missense_Mutation_p.R605L|PPIG_uc002ufd.2_Missense_Mutation_p.R602L	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	605	Arg/Ser-rich (RS domain).				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	GGACGGTCACGAAGCCGAGAG	0.488			NA											5	26					2.7689e-08	3.81291e-08	0.001984	1	0
TTN	7273	broad.mit.edu	37	2	179451522	179451522	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:179451522G>A	uc010zfg.1	-	257	56626	c.56402C>T	c.(56401-56403)CCC>CTC	p.P18801L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P12496L|TTN_uc010zfi.1_Missense_Mutation_p.P12429L|TTN_uc010zfj.1_Missense_Mutation_p.P12304L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19728							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCTTGGGGGATCCGGCTC	0.408			NA											10	104					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179583959	179583959	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:179583959C>A	uc010zfg.1	-	80	20650	c.20426G>T	c.(20425-20427)GGC>GTC	p.G6809V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G3470V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7736							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTGTATATGCCTGTGTCGGA	0.502			NA											6	107					0.00116845	0.00135379	0.001168	1	0
NRP2	8828	broad.mit.edu	37	2	206581060	206581061	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:206581060_206581061GG>TT	uc002vaw.2	+	3	1186_1187	c.395_396GG>TT	c.(394-396)GGG>GTT	p.G132V	NRP2_uc002vat.2_Missense_Mutation_p.G132V|NRP2_uc002vau.2_Missense_Mutation_p.G132V|NRP2_uc002vav.2_Missense_Mutation_p.G132V|NRP2_uc002vax.2_Missense_Mutation_p.G132V|NRP2_uc002vay.2_Missense_Mutation_p.G132V|NRP2_uc010fud.2_Missense_Mutation_p.G132V	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	132	Extracellular (Potential).|CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GCCCGGCAGGGGGCAGGCTTCT	0.609			NA											19	78					0	0	0.004672	0	0
ARMC9	80210	broad.mit.edu	37	2	232146780	232146780	+	Silent	SNP	G	G	A	rs34385474	byFrequency	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:232146780G>A	uc002vrq.3	+	17	1672	c.1560G>A	c.(1558-1560)CCG>CCA	p.P520P	ARMC9_uc002vrp.3_Silent_p.P520P|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	520							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		AGATACAGCCGTATGTGAATG	0.423			NA											7	140					0	0	0.00308	0	0
OTOS	150677	broad.mit.edu	37	2	241078674	241078674	+	Silent	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr2:241078674G>T	uc002vyv.2	-	4	338	c.183C>A	c.(181-183)CCC>CCA	p.P61P	MYEOV2_uc002vyu.1_5'Flank|MYEOV2_uc010zof.1_5'Flank	NM_148961	NP_683764	Q8NHW6	OTOSP_HUMAN	otospiralin precursor	61						extracellular region					0		all_epithelial(40;2.79e-15)|Breast(86;3.04e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|Hepatocellular(293;0.148)|all_hematologic(139;0.158)|Melanoma(123;0.16)		Epithelial(32;2.56e-30)|all cancers(36;7.18e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.37e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.07e-06)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		CCTCGATCTGGGGGTAGGCCC	0.622			NA											11	114					1.58986e-06	2.11982e-06	0.008291	1	0
HSPA12B	116835	broad.mit.edu	37	20	3728940	3728940	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr20:3728940G>A	uc002wjd.2	+	8	855	c.752G>A	c.(751-753)CGC>CAC	p.R251H	HSPA12B_uc010zqi.1_Missense_Mutation_p.R250H|HSPA12B_uc002wje.2_Missense_Mutation_p.R164H|HSPA12B_uc010zqj.1_Missense_Mutation_p.R85H	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	251							ATP binding				0						GTATACTGCCGCAAGCTGCGC	0.682			NA											11	62					0	0	0.000978	0	0
CEP250	11190	broad.mit.edu	37	20	34078568	34078568	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr20:34078568A>G	uc002xcm.2	+	22	3363	c.2692A>G	c.(2692-2694)ATG>GTG	p.M898V	CEP250_uc010zve.1_Missense_Mutation_p.M266V	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	898	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCAGACAGAAATGGAGGCCAT	0.572			NA											7	94					0	0	0.00308	0	0
ZNF217	7764	broad.mit.edu	37	20	52198292	52198292	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr20:52198292C>T	uc002xwq.3	-	1	1345	c.1074G>A	c.(1072-1074)GCG>GCA	p.A358A	ZNF217_uc010gij.1_Silent_p.A350A	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	358					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CCACGGAGGGCGCTTCGCCGT	0.557			NA											9	110					0	0	0.004482	0	0
OPRL1	4987	broad.mit.edu	37	20	62730084	62730084	+	Missense_Mutation	SNP	G	G	A	rs138440707		TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr20:62730084G>A	uc002yic.2	+	5	1447	c.1045G>A	c.(1045-1047)GTG>ATG	p.V349M	OPRL1_uc002yid.2_Missense_Mutation_p.V349M|OPRL1_uc002yif.3_Missense_Mutation_p.V344M	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	349	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GTCTGACCGCGTGCGCAGCAT	0.642			NA											14	49					0	0	0.001855	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410632	32410632	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr21:32410632T>G	uc010glt.2	-	1	164	c.131A>C	c.(130-132)TAT>TCT	p.Y44S		NM_001099219	NP_001092689	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	44						intermediate filament				upper_aerodigestive_tract(1)	1						GCTGAATCCATAGCCTCCGTA	0.517			NA											19	97					0	0	0.008871	0	0
TBX1	6899	broad.mit.edu	37	22	19750849	19750849	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr22:19750849G>A	uc002zqb.2	+	4	625	c.496G>A	c.(496-498)GAC>AAC	p.D166N	TBX1_uc002zqa.1_Missense_Mutation_p.D166N|TBX1_uc002zqc.2_Missense_Mutation_p.D166N	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	166	T-box.				embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				CGTGCCGGTGGACGATAAGCG	0.612			NA											13	40					0	0	0.001855	0	0
HHATL	57467	broad.mit.edu	37	3	42735266	42735266	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr3:42735266G>T	uc003clw.2	-	11	1238	c.1091C>A	c.(1090-1092)CCA>CAA	p.P364Q	HHATL_uc003clx.2_Missense_Mutation_p.P364Q	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	364					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TGCCAGCTCTGGGATCACAGC	0.542			NA											6	37					2.7689e-08	3.81291e-08	0.001984	1	0
KCNAB1	7881	broad.mit.edu	37	3	156175266	156175266	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr3:156175266G>A	uc003far.2	+	4	446	c.382G>A	c.(382-384)GCC>ACC	p.A128T	KCNAB1_uc011bon.1_Missense_Mutation_p.A128T|KCNAB1_uc003fas.2_Missense_Mutation_p.A117T|KCNAB1_uc003fat.2_Missense_Mutation_p.A110T|KCNAB1_uc010hvt.1_Missense_Mutation_p.A110T|KCNAB1_uc011boo.1_Missense_Mutation_p.A4T	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	128						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GATGACCATCGCCTATGAAAG	0.473			NA											14	97					0	0	0.004007	0	0
ACAP2	23527	broad.mit.edu	37	3	195000115	195000115	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr3:195000115A>G	uc003fun.3	-	23	2520	c.2279T>C	c.(2278-2280)ATG>ACG	p.M760T		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	760					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						ATTGGATGCCATTTGGGAAAA	0.313			NA											9	35					0	0	0.008291	0	0
PIGG	54872	broad.mit.edu	37	4	515677	515677	+	Missense_Mutation	SNP	G	G	A	rs138569779	byFrequency	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr4:515677G>A	uc003gak.3	+	8	1697	c.1561G>A	c.(1561-1563)GTG>ATG	p.V521M	PIGG_uc003gaj.3_Missense_Mutation_p.V513M|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.V388M|PIGG_uc003gal.3_Missense_Mutation_p.V432M|PIGG_uc003gai.2_Intron|PIGG_uc011buw.1_3'UTR|PIGG_uc003gam.2_3'UTR|PIGG_uc003gan.2_Missense_Mutation_p.V432M	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	521	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GCTGCTGTGTGTGATTGTGTC	0.587			NA											5	60					0	0	0.000602	0	0
PCDH10	57575	broad.mit.edu	37	4	134073195	134073195	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr4:134073195C>G	uc003iha.2	+	1	2726	c.1900C>G	c.(1900-1902)CGC>GGC	p.R634G	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.R634G	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	634	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CATGGACTGGCGCACCGGGGA	0.692			NA											19	53					0	0	0.001882	0	0
IQGAP2	10788	broad.mit.edu	37	5	75996968	75996968	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr5:75996968G>T	uc003kek.2	+	34	4657	c.4435G>T	c.(4435-4437)GTG>TTG	p.V1479L	IQGAP2_uc011csv.1_Missense_Mutation_p.V975L|IQGAP2_uc003kel.2_Missense_Mutation_p.V975L	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1479					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGCGAAGCCAGTGAAGTACAC	0.408			NA											10	59					2.17888e-05	2.77312e-05	0.006214	1	0
FER	2241	broad.mit.edu	37	5	108382819	108382819	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr5:108382819A>G	uc003kop.1	+	16	2228	c.1844A>G	c.(1843-1845)TAT>TGT	p.Y615C	FER_uc011cvg.1_Missense_Mutation_p.Y440C	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	615	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		CTCAAGCAATATGATCATCCC	0.313	Colon(146;1051 1799 9836 27344 47401)		NA											5	27					0	0	0.000602	0	0
SLC6A7	6534	broad.mit.edu	37	5	149578887	149578887	+	Silent	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr5:149578887C>A	uc003lrr.2	+	5	1052	c.681C>A	c.(679-681)ATC>ATA	p.I227I		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	227	Helical; Name=4; (Potential).					integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	CCTGGGTCATCGTGTTCCTCT	0.423			NA											23	64					1.22574e-08	1.71603e-08	0.002299	1	0
CDHR2	54825	broad.mit.edu	37	5	176011494	176011494	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr5:176011494G>A	uc003mem.1	+	19	2278	c.2212G>A	c.(2212-2214)GGT>AGT	p.G738S	CDHR2_uc003men.1_Missense_Mutation_p.G738S	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	738	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GTCGGGGAGTGGTGCCAACTA	0.642			NA											42	134					0	0	0.002222	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178540919	178540919	+	Silent	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr5:178540919G>T	uc003mjw.2	-	22	3585	c.3585C>A	c.(3583-3585)ATC>ATA	p.I1195I	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1195					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGAGCTCTTGGATTCTTTGGT	0.433			NA											13	136					2.68362e-12	4.02543e-12	0.001368	1	0
PIP5K1P1	206426	broad.mit.edu	37	6	7987629	7987629	+	Missense_Mutation	SNP	C	C	A	rs138980345	by1000genomes	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr6:7987629C>A	uc003mxx.3	+	1	1295	c.860C>A	c.(859-861)ACG>AAG	p.T287K	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						GATGCTGACACGTACAATGCT	0.468			NA											5	36					3.59834e-05	4.47793e-05	0.001168	1	0
OR2B2	81697	broad.mit.edu	37	6	27879450	27879450	+	Silent	SNP	T	T	G	rs147063988	by1000genomes	TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr6:27879450T>G	uc011dkw.1	-	1	648	c.648A>C	c.(646-648)ATA>ATC	p.I216I		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGCATACGATATAAGGATGA	0.443			NA											3	47					0	0	0.000602	0	0
TAP2	6891	broad.mit.edu	37	6	32803552	32803552	+	Splice_Site	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr6:32803552T>A	uc003occ.2	-	3	640	c.609_splice	c.e3-1	p.S203_splice	TAP2_uc011dqf.1_Splice_Site_p.S203_splice|TAP2_uc003ocb.1_Splice_Site_p.S203_splice|TAP2_uc003ocd.2_Splice_Site_p.S203_splice	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family						antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GACAGTGAGCTGTGGGGTAGG	0.582			NA											7	72					0	0	0.006214	0	0
DST	667	broad.mit.edu	37	6	56371588	56371588	+	Splice_Site	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr6:56371588C>A	uc003pdf.2	-	70	12911	c.12883_splice	c.e70-1	p.T4295_splice	DST_uc003pcz.3_Splice_Site_p.T4117_splice|DST_uc011dxj.1_Splice_Site_p.T4146_splice|DST_uc011dxk.1_Splice_Site_p.T4157_splice|DST_uc003pcy.3_Splice_Site_p.T3791_splice	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCCTTATGGTCTAGAATAAGA	0.378			NA											27	94					4.02929e-09	5.78564e-09	0.002096	1	0
PRIM2	5558	broad.mit.edu	37	6	57398228	57398228	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr6:57398228C>A	uc003pdx.2	+	10	1018	c.931C>A	c.(931-933)CTA>ATA	p.L311I		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	311					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GCAGTATGTCCTATTTCTGAA	0.403			NA											6	188					5.4927e-09	7.82012e-09	0.004482	1	0
MRPL18	29074	broad.mit.edu	37	6	160211662	160211662	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr6:160211662A>G	uc003qsw.3	+	1	171	c.43A>G	c.(43-45)AGG>GGG	p.R15G	TCP1_uc003qsr.2_5'Flank|TCP1_uc003qss.2_5'Flank|TCP1_uc010kjz.2_5'Flank|TCP1_uc003qst.2_5'Flank|TCP1_uc010kka.1_5'Flank|MRPL18_uc010kkb.2_Intron	NM_014161	NP_054880	Q9H0U6	RM18_HUMAN	mitochondrial ribosomal protein L18 precursor	15					rRNA transport|translation	mitochondrial ribosome	5S rRNA binding|structural constituent of ribosome				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.79e-06)		CTCGGTTTGCAGGAACCCTGG	0.557			NA											3	63					0	0	0.000248	0	0
C7orf28B	221960	broad.mit.edu	37	7	6862974	6862974	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr7:6862974C>T	uc003sqx.1	-	5	441	c.408G>A	c.(406-408)TCG>TCA	p.S136S	C7orf28B_uc011jxd.1_5'UTR|C7orf28B_uc003sqy.1_3'UTR	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960	136						lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		GCCGCAGCACCGAGCTATAAA	0.493			NA											11	97					0	0	0.007413	0	0
ABCB5	340273	broad.mit.edu	37	7	20721241	20721241	+	Silent	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr7:20721241T>A	uc003suw.3	+	6	1032	c.486T>A	c.(484-486)GCT>GCA	p.A162A	ABCB5_uc010kuh.2_Silent_p.A607A	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	162	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GAGCACATGCTGAACTAATGG	0.428			NA											10	51					0	0	0.008291	0	0
AKAP9	10142	broad.mit.edu	37	7	91622330	91622330	+	Silent	SNP	A	A	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr7:91622330A>G	uc003ulg.2	+	5	762	c.537A>G	c.(535-537)GAA>GAG	p.E179E	AKAP9_uc003uld.3_Silent_p.E179E|AKAP9_uc003ule.2_Silent_p.E191E|AKAP9_uc003ulf.2_Silent_p.E179E	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	191	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGAGCTGGAAGAAATGAGGG	0.433			NA	T	BRAF	papillary thyroid								6	51					0	0	0.001984	0	0
PRSS37	136242	broad.mit.edu	37	7	141537006	141537006	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr7:141537006A>C	uc003vws.1	-	4	845	c.473T>G	c.(472-474)ATG>AGG	p.M158R	PRSS37_uc011krk.1_Missense_Mutation_p.M145R|PRSS37_uc011krl.1_Missense_Mutation_p.M157R|PRSS37_uc003vwt.1_Missense_Mutation_p.M145R	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	158	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						TCGATCAGACATCACGGGGGC	0.453			NA											7	70					0	0	0.004482	0	0
CSMD1	64478	broad.mit.edu	37	8	2824215	2824215	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:2824215C>A	uc011kwk.1	-	58	9370	c.8980G>T	c.(8980-8982)GAT>TAT	p.D2994Y	CSMD1_uc011kwj.1_Missense_Mutation_p.D2323Y|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2994	Extracellular (Potential).|Sushi 23.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGAATGCCATCACTACTGACA	0.552			NA											4	20					0.00198382	0.0022519	0.001984	1	0
CSMD1	64478	broad.mit.edu	37	8	3216716	3216716	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:3216716C>A	uc011kwk.1	-	21	3655	c.3265G>T	c.(3265-3267)GGG>TGG	p.G1089W	CSMD1_uc011kwj.1_Missense_Mutation_p.G481W|CSMD1_uc003wqe.2_Missense_Mutation_p.G245W	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1089	Sushi 6.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGGCGGCCCCCACCCAGGCAG	0.557			NA											12	113					0.00316338	0.00356676	0.003163	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767139	77767139	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:77767139G>A	uc003yav.2	+	10	8234	c.7847G>A	c.(7846-7848)AGG>AAG	p.R2616K	ZFHX4_uc003yau.1_Missense_Mutation_p.R2661K|ZFHX4_uc003yaw.1_Missense_Mutation_p.R2616K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2616	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCGCGGGAGAGGAAAGGCCAG	0.522			NA								HNSCC(33;0.089)			19	89					0	0	0.006122	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768513	77768513	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:77768513C>A	uc003yav.2	+	10	9608	c.9221C>A	c.(9220-9222)CCG>CAG	p.P3074Q	ZFHX4_uc003yau.1_Missense_Mutation_p.P3119Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.P3074Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3074	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCTCCTTGCCGGGATTTCCA	0.512			NA								HNSCC(33;0.089)			12	41					0.00010058	0.000123339	0.001368	1	0
RIMS2	9699	broad.mit.edu	37	8	105261795	105261795	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:105261795C>T	uc003yls.2	+	26	3965	c.3724C>T	c.(3724-3726)CCA>TCA	p.P1242S	RIMS2_uc003ylp.2_Missense_Mutation_p.P1224S|RIMS2_uc003ylw.2_Missense_Mutation_p.P1231S|RIMS2_uc003ylq.2_Missense_Mutation_p.P1038S|RIMS2_uc003ylr.2_Missense_Mutation_p.P1063S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1286	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGTTGTAAAACCAGGTTCCAA	0.403			NA								HNSCC(12;0.0054)			4	43					0	0	0.000248	0	0
MAL2	114569	broad.mit.edu	37	8	120252494	120252494	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:120252494C>T	uc003yop.2	+	4	495	c.393C>T	c.(391-393)TGC>TGT	p.C131C		NM_052886	NP_443118	Q969L2	MAL2_HUMAN	MAL2 proteolipid protein	131	Lumenal (Potential).|MARVEL.					apical plasma membrane|endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding				0	all_cancers(13;1.91e-26)|Lung NSC(37;8.61e-08)|Ovarian(258;0.018)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000967)			ATTTGCATTGCAATACAACCA	0.403			NA											7	51					0	0	0.00308	0	0
ENPP2	5168	broad.mit.edu	37	8	120594688	120594688	+	Silent	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:120594688G>T	uc003yot.1	-	18	1784	c.1698C>A	c.(1696-1698)GGC>GGA	p.G566G	ENPP2_uc011lic.1_Silent_p.G83G|ENPP2_uc003yor.1_Silent_p.G205G|ENPP2_uc003yos.1_Silent_p.G618G|ENPP2_uc010mdd.1_Silent_p.G566G	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	566					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CACAAGTGCAGCCCAGGTCAA	0.383	Melanoma(20;305 879 2501 4818 31020)		NA											18	99					1.02788e-11	1.51478e-11	0.00499	1	0
NFKBIL2	4796	broad.mit.edu	37	8	145661703	145661703	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr8:145661703T>C	uc011llg.1	-	17	2128	c.2113A>G	c.(2113-2115)AGC>GGC	p.S705G	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	705					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGTCTAGTGCTATTAGAGGGG	0.652			NA											6	90					0	0	0.001984	0	0
TMEM215	401498	broad.mit.edu	37	9	32784340	32784340	+	Silent	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:32784340C>T	uc003zri.3	+	2	524	c.159C>T	c.(157-159)GGC>GGT	p.G53G		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	53	Helical; (Potential).					integral to membrane					0						GCCTACCAGGCATCGCAGCCA	0.587			NA											10	50					0	0	0.006214	0	0
KIAA1161	57462	broad.mit.edu	37	9	34371852	34371852	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:34371852C>T	uc003zue.3	-	3	1257	c.1090G>A	c.(1090-1092)GAC>AAC	p.D364N		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	364	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		TCATCGAAGTCGAAGTCGCCA	0.582			NA											6	62					0	0	0.001168	0	0
ASTN2	23245	broad.mit.edu	37	9	119202889	119202889	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:119202889T>A	uc004bjs.1	-	22	3882	c.3781A>T	c.(3781-3783)AGG>TGG	p.R1261W	ASTN2_uc004bjr.1_Missense_Mutation_p.R1257W|ASTN2_uc004bjt.1_Missense_Mutation_p.R1210W|ASTN2_uc004bjp.1_Missense_Mutation_p.R354W|ASTN2_uc004bjq.1_Missense_Mutation_p.R313W|ASTN2_uc011lxr.1_Missense_Mutation_p.R313W|ASTN2_uc011lxs.1_Missense_Mutation_p.R313W|ASTN2_uc011lxt.1_Missense_Mutation_p.R313W|ASTN2_uc004bjo.1_Missense_Mutation_p.R42W	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1261	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGCCCATACCTGGGCCCCAGC	0.507			NA											5	45					0	0	0.000602	0	0
TOR1A	1861	broad.mit.edu	37	9	132584947	132584947	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:132584947A>C	uc004byl.2	-	2	434	c.357T>G	c.(355-357)ATT>ATG	p.I119M	TOR1A_uc004bym.2_RNA|TOR1A_uc004byn.2_Missense_Mutation_p.I119M	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	119					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				CACCCTCGTAAATATTCTCTG	0.488			NA											10	128					0	0	0.000978	0	0
NUP214	8021	broad.mit.edu	37	9	134034776	134034776	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:134034776C>T	uc004cag.2	+	18	2554	c.2443C>T	c.(2443-2445)CGG>TGG	p.R815W	NUP214_uc004cah.2_Missense_Mutation_p.R805W|NUP214_uc004cai.2_Missense_Mutation_p.R245W|NUP214_uc004caf.1_Missense_Mutation_p.R804W|NUP214_uc010mzf.2_Missense_Mutation_p.R113W	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	815	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		ATAGGAAATTCGGCGCCTTCA	0.343	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								6	25					0	0	0.001984	0	0
CACNA1B	774	broad.mit.edu	37	9	140968458	140968458	+	Silent	SNP	G	G	T			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:140968458G>T	uc004cog.2	+	33	4942	c.4797G>T	c.(4795-4797)CTG>CTT	p.L1599L	CACNA1B_uc004coi.2_Silent_p.L811L|CACNA1B_uc004cok.1_5'Flank|CACNA1B_uc010ncp.1_5'Flank	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1599	Cytoplasmic (Potential).|IV.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGCAGGCCCTGCCCTACGTGT	0.577			NA											29	114					8.16721e-17	1.27045e-16	0.002096	1	0
FAM47C	442444	broad.mit.edu	37	X	37027425	37027425	+	Silent	SNP	C	C	G			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chrX:37027425C>G	uc004ddl.1	+	1	956	c.942C>G	c.(940-942)CGC>CGG	p.R314R		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	314										ovary(3)	3						CCAAGTCACGCGTATCTCATC	0.607			NA											20	37					0	0	0.008871	0	0
ZIC3	7547	broad.mit.edu	37	X	136649338	136649338	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chrX:136649338C>A	uc004fak.2	+	1	993	c.488C>A	c.(487-489)CCC>CAC	p.P163H		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	163					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TTGCTGTTTCCCGGGCTGCAT	0.711			NA											13	31					0.000308642	0.000367744	0.003163	1	0
AFF2	2334	broad.mit.edu	37	X	148037518	148037518	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chrX:148037518C>A	uc004fcp.2	+	11	2422	c.1943C>A	c.(1942-1944)CCA>CAA	p.P648Q	AFF2_uc004fcq.2_Missense_Mutation_p.P638Q|AFF2_uc004fcr.2_Missense_Mutation_p.P609Q|AFF2_uc011mxb.1_Missense_Mutation_p.P613Q|AFF2_uc004fcs.2_Missense_Mutation_p.P615Q|AFF2_uc011mxc.1_Missense_Mutation_p.P289Q	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	648					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCCAAACCAAATATTACC	0.478			NA											48	48					6.08268e-21	9.55038e-21	0.00361	1	0
F8	2157	broad.mit.edu	37	X	154159066	154159066	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chrX:154159066G>A	uc004fmt.2	-	14	3170	c.2999C>T	c.(2998-3000)CCT>CTT	p.P1000L		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1000	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAACAAAGCAGGTCCATGAGC	0.343			NA											16	47					0	0	0.00499	0	0
FLT3	2322	broad.mit.edu	37	13	28589835	28589835	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr13:28589835delG	uc001urw.2	-	21	2627	c.2545delC	c.(2545-2547)CGTfs	p.R849fs	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Frame_Shift_Del_p.R808fs	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	849	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACAGGCAGACGGGCCTGTGGA	0.413			NA	Mis|O		AML|ALL								13	61	---	---	---	---	NA	NA	NA	NA	NA
EIF2AK4	440275	broad.mit.edu	37	15	40268969	40268969	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr15:40268969delG	uc001zkm.1	+	12	2223	c.2173delG	c.(2173-2175)GCCfs	p.A725fs	EIF2AK4_uc010bbj.1_Frame_Shift_Del_p.A454fs	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	725	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CCGTTTCCCCGCCACCGGCCC	0.711			NA											10	89	---	---	---	---	NA	NA	NA	NA	NA
C17orf87	388325	broad.mit.edu	37	17	5124612	5124612	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr17:5124612delT	uc002gbh.2	-	3	212	c.179delA	c.(178-180)CACfs	p.H60fs	uc002gbf.1_Intron|uc002gbg.1_Intron|C17orf87_uc010clb.1_Frame_Shift_Del_p.H53fs|C17orf87_uc002gbi.2_Frame_Shift_Del_p.H53fs	NM_207103	NP_996986	Q6UWF3	CQ087_HUMAN	hypothetical protein LOC388325	60						integral to membrane				ovary(1)	1						TACTTGCTTGTGTTTCAGGGG	0.423			NA											8	95	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1207136	1207137	+	Frame_Shift_Ins	INS	-	-	CTCCT			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr19:1207136_1207137insCTCCT	uc002lrl.1	+	1	1339_1340	c.224_225insCTCCT	c.(223-225)AGGfs	p.R75fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	75	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(3)|p.G52_P179del(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGTGCAGGAGGGCCGTCAAGA	0.619			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			9	19	---	---	---	---	NA	NA	NA	NA	NA
PURA	5813	broad.mit.edu	37	5	139493896	139493898	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	GGC	GGC	-	-	GGC	GGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr5:139493896_139493898delGGC	uc003lfa.2	+	1	189_191	c.130_132delGGC	c.(130-132)GGCdel	p.G49del		NM_005859	NP_005850	Q00577	PURA_HUMAN	purine-rich element binding protein A	49	Gly-rich.				DNA unwinding involved in replication|DNA-dependent DNA replication initiation	DNA replication factor A complex	double-stranded telomeric DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|single-stranded DNA binding|transcription factor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			cggcggcagtggcggcggcggcg	0.517			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
ASTN2	23245	broad.mit.edu	37	9	119976964	119976964	+	Frame_Shift_Del	DEL	G	G	-	rs149649522		TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chr9:119976964delG	uc004bjs.1	-	3	789	c.688delC	c.(688-690)CAGfs	p.Q230fs	ASTN2_uc004bjr.1_Frame_Shift_Del_p.Q230fs|ASTN2_uc004bjt.1_Frame_Shift_Del_p.Q230fs	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	230	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CAACGTCGCTGGGCGTACAGC	0.607			NA											7	60	---	---	---	---	NA	NA	NA	NA	NA
RBM10	8241	broad.mit.edu	37	X	47041355	47041355	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6983-01A-11D-1945-08	TCGA-55-6983-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6d4d37e4-0f9b-4f44-bda6-f4c280067d72	f71b30ee-ce4c-4a56-9cf9-ad2e139a5689	g.chrX:47041355delC	uc004dhf.2	+	16	2078	c.1699delC	c.(1699-1701)CCCfs	p.P567fs	RBM10_uc004dhg.2_Frame_Shift_Del_p.P489fs|RBM10_uc004dhh.2_Frame_Shift_Del_p.P566fs|RBM10_uc010nhq.2_Frame_Shift_Del_p.P490fs|RBM10_uc004dhi.2_Frame_Shift_Del_p.P632fs	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	567	Tyr-rich.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CCTAGCTGTTCCCGACGTCTC	0.577	Melanoma(171;120 2705 19495 39241)		NA											20	13	---	---	---	---	NA	NA	NA	NA	NA
