Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SSU72	29101	broad.mit.edu	37	1	1500188	1500188	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:1500188C>T	uc001agd.2	-	2	514	c.189G>A	c.(187-189)CAG>CAA	p.Q63Q	SSU72_uc009vkg.1_Silent_p.Q63Q|SSU72_uc001age.1_Silent_p.Q63Q	NM_014188	NP_054907	Q9NP77	SSU72_HUMAN	Ssu72 RNA polymerase II CTD phosphatase homolog	63					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity				0	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CATTGTACATCTGGTCATATG	0.493			NA											10	105					0	0	0.006214	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528512	6528512	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:6528512G>A	uc001ano.1	-	21	2653	c.2552C>T	c.(2551-2553)TCT>TTT	p.S851F	PLEKHG5_uc001ann.1_Missense_Mutation_p.S832F|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.S872F|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.S356F|PLEKHG5_uc009vma.1_Missense_Mutation_p.S635F|PLEKHG5_uc010nzr.1_Missense_Mutation_p.S864F|PLEKHG5_uc001ank.1_Missense_Mutation_p.S795F|PLEKHG5_uc009vmb.1_Missense_Mutation_p.S795F|PLEKHG5_uc001anl.1_Missense_Mutation_p.S795F|PLEKHG5_uc001anm.1_Missense_Mutation_p.S795F|PLEKHG5_uc001anr.1_Missense_Mutation_p.S58F	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	851					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGGCGTGGCAGATGAGGCAGT	0.637			NA											5	22					0	0	0.001168	0	0
EPHA8	2046	broad.mit.edu	37	1	22915468	22915468	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:22915468T>C	uc001bfx.1	+	5	1209	c.1084T>C	c.(1084-1086)TAC>CAC	p.Y362H	EPHA8_uc001bfw.2_Missense_Mutation_p.Y362H	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	362	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGACATCACCTACAATGCCGT	0.657			NA											4	27					0	0	0.000602	0	0
MYOM3	127294	broad.mit.edu	37	1	24406539	24406539	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:24406539G>A	uc001bin.3	-	20	2716	c.2553C>T	c.(2551-2553)GTC>GTT	p.V851V	MYOM3_uc001bim.3_Silent_p.V508V|MYOM3_uc001bio.2_Silent_p.V851V	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	851	Fibronectin type-III 5.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGCCTGGGGTGACCGGCTTCC	0.552			NA											6	65					0	0	0.001168	0	0
IFI6	2537	broad.mit.edu	37	1	27992960	27992960	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:27992960C>G	uc001boo.1	-	5	448	c.325G>C	c.(325-327)GGT>CGT	p.G109R	IFI6_uc001bon.1_Missense_Mutation_p.G117R|IFI6_uc001bop.1_Missense_Mutation_p.G113R	NM_002038	NP_002029	P09912	IFI6_HUMAN	interferon, alpha-inducible protein 6 isoform a	109					anti-apoptosis|negative regulation of caspase activity|negative regulation of mitochondrial depolarization|release of cytochrome c from mitochondria|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion	protein binding			ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;7.75e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCAATATTACCTATGACGACG	0.537			NA											6	44					0	0	0.00308	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047735	42047735	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:42047735C>G	uc001cgz.3	-	4	3947	c.2734G>C	c.(2734-2736)GAG>CAG	p.E912Q	HIVEP3_uc001cha.3_Missense_Mutation_p.E912Q|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	912	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGGCCATCTCTGCCAGGCGC	0.592			NA											8	127					0	0	0.00308	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047774	42047774	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:42047774C>G	uc001cgz.3	-	4	3908	c.2695G>C	c.(2695-2697)GAG>CAG	p.E899Q	HIVEP3_uc001cha.3_Missense_Mutation_p.E899Q|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	899	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGCAGCTTCTCAGCTGGGAGC	0.622			NA											8	86					0	0	0.004482	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403713	47403713	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:47403713G>T	uc001cqp.3	-	2	343	c.292C>A	c.(292-294)CAG>AAG	p.Q98K	CYP4A11_uc001cqq.2_Missense_Mutation_p.Q98K|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	98					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TCATAGAGCTGGACACGAACT	0.517			NA											10	86					2.17888e-05	2.592e-05	0.006214	1	0
TM2D1	83941	broad.mit.edu	37	1	62190779	62190779	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:62190779C>G	uc001czz.1	-	1	317	c.14G>C	c.(13-15)TGG>TCG	p.W5S		NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor	5					apoptosis					ovary(1)	1						ACCAGACGGCCAGGCGGCCGC	0.652			NA											7	81					0	0	0.004482	0	0
JAK1	3716	broad.mit.edu	37	1	65332689	65332689	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:65332689C>T	uc001dbu.1	-	7	1099	c.850G>A	c.(850-852)GAA>AAA	p.E284K	JAK1_uc009wam.1_Missense_Mutation_p.E272K	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	284	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCAAATATTTCAGCACCGTAA	0.398			NA	Mis		ALL								9	100					0	0	0.004482	0	0
LRRC8C	84230	broad.mit.edu	37	1	90180404	90180404	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:90180404G>A	uc001dnl.3	+	3	2517	c.2275G>A	c.(2275-2277)GTA>ATA	p.V759I		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	759	LRR 16.					endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CTACTTAGATGTAAAAGGTAA	0.393			NA											5	55					0	0	0.000602	0	0
CHD1L	9557	broad.mit.edu	37	1	146756095	146756095	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:146756095G>C	uc001epm.3	+	16	1840	c.1777G>C	c.(1777-1779)GAA>CAA	p.E593Q	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.E480Q|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.E499Q|CHD1L_uc010ozp.1_Missense_Mutation_p.E312Q|CHD1L_uc001epo.3_Missense_Mutation_p.E389Q|CHD1L_uc010ozq.1_Missense_Mutation_p.E166Q|CHD1L_uc009wji.2_Missense_Mutation_p.E312Q	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	593					chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					AAAATCATTTGAACAACTGGT	0.333			NA											8	88					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	1	148891528	148891528	+	Splice_Site	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:148891528G>T	uc009wkv.1	+	9		c.831_splice	c.e9-1							Homo sapiens cDNA, FLJ17483.												NA						TGTAATTTTAGACCCACCCAA	0.373			NA											4	32					0.00909568	0.00980116	0.009096	1	0
TARS2	80222	broad.mit.edu	37	1	150477190	150477190	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:150477190G>A	uc001euq.2	+	15	1808	c.1801G>A	c.(1801-1803)GAA>AAA	p.E601K	TARS2_uc001eur.2_Missense_Mutation_p.E519K|TARS2_uc009wlt.2_Missense_Mutation_p.E227K|TARS2_uc009wls.2_Missense_Mutation_p.E471K	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	601					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	AGTGCTGGCAGAAAGCTGCGG	0.567			NA											8	153					0	0	0.00308	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105617	151105617	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:151105617G>A	uc001ewu.2	-	19	2436	c.2136C>T	c.(2134-2136)CTC>CTT	p.L712L	SEMA6C_uc001ewv.2_Silent_p.L744L|SEMA6C_uc001eww.2_Silent_p.L704L|SEMA6C_uc010pcq.1_Missense_Mutation_p.S646F	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	712	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGGCGGCGCGGAGGTGCTTGA	0.617			NA											7	21					0	0	0.00308	0	0
FLG	2312	broad.mit.edu	37	1	152284856	152284856	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:152284856C>T	uc001ezu.1	-	3	2542	c.2506G>A	c.(2506-2508)GAT>AAT	p.D836N	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	836	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGACCATCTTGGGATGCT	0.587			NA							Ichthyosis				34	555					0	0	0.004878	0	0
INTS3	65123	broad.mit.edu	37	1	153740270	153740270	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:153740270C>T	uc009wom.2	+	22	2432	c.2211C>T	c.(2209-2211)CTC>CTT	p.L737L	INTS3_uc001fct.2_Silent_p.L737L|INTS3_uc001fcu.2_Silent_p.L429L|INTS3_uc001fcv.2_Silent_p.L531L|INTS3_uc010peb.1_Silent_p.L531L|INTS3_uc001fcw.2_Silent_p.L250L|INTS3_uc010pec.1_Silent_p.L250L|INTS3_uc001fcy.2_Silent_p.L34L|INTS3_uc001fcx.2_Silent_p.L34L	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	738					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ATGTGCGGCTCCTGTGCCACC	0.592			NA											7	74					0	0	0.00308	0	0
PKLR	5313	broad.mit.edu	37	1	155264172	155264172	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:155264172C>G	uc001fkb.3	-	7	1009	c.970G>C	c.(970-972)GAT>CAT	p.D324H	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.D293H	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	324					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	AGGATTTCATCAAACCTGAGA	0.562			NA											5	48					0	0	0.000602	0	0
RUSC1	23623	broad.mit.edu	37	1	155292113	155292113	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:155292113C>A	uc001fkj.2	+	2	778	c.549C>A	c.(547-549)AAC>AAA	p.N183K	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.N183K|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	183						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CGAACTGCAACGCCCTGACCA	0.627			NA											6	104					0.00307968	0.0034034	0.00308	1	0
NES	10763	broad.mit.edu	37	1	156640010	156640010	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:156640010G>A	uc001fpq.2	-	4	4103	c.3970C>T	c.(3970-3972)CAA>TAA	p.Q1324*		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1324	Tail.			DPTGEQRPPPQG -> TPLESRGHPLK (in Ref. 1; CAA46780).	brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTCTCCCCTTGAGGGGGTGGC	0.577			NA											8	136					0	0	0.00308	0	0
INSRR	3645	broad.mit.edu	37	1	156823675	156823675	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:156823675C>G	uc010pht.1	-	2	760	c.506G>C	c.(505-507)GGC>GCC	p.G169A	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.G169A	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	169					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGCTTGTTGCCCACGATGTG	0.637			NA											11	29					0	0	0.010729	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576991	158576991	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:158576991G>C	uc010pio.1	+	1	763	c.763G>C	c.(763-765)GCT>CCT	p.A255P		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TTATGGCTGTGCTTCCTTCGT	0.512			NA											52	223					0	0	0.00361	0	0
UAP1	6675	broad.mit.edu	37	1	162557435	162557435	+	Silent	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:162557435A>T	uc001gce.3	+	6	1334	c.1005A>T	c.(1003-1005)GTA>GTT	p.V335V		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	335					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TCTTCACTGTACCATTTCTGA	0.418			NA											15	148					0	0	0.004007	0	0
SLC19A2	10560	broad.mit.edu	37	1	169439421	169439421	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:169439421G>A	uc001gge.3	-	3	1015	c.811C>T	c.(811-813)CCC>TCC	p.P271S	SLC19A2_uc001ggf.3_Missense_Mutation_p.P70S	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	271	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					TCTGGCTTGGGTTCCTACATA	0.443			NA											4	61					0	0	0.009096	0	0
RASAL2	9462	broad.mit.edu	37	1	178421649	178421649	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:178421649C>G	uc001glr.2	+	9	1552	c.1427C>G	c.(1426-1428)TCA>TGA	p.S476*	RASAL2_uc001glq.2_Nonsense_Mutation_p.S624*|RASAL2_uc009wxc.2_5'UTR	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	476	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						ATCAGTGCCTCATTATTTCTC	0.478			NA											10	200					0	0	0.006214	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200776585	200776585	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:200776585G>T	uc001gvl.2	+	3	751	c.481G>T	c.(481-483)GCT>TCT	p.A161S	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.A161S|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.A161S	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	161						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						AATTGCGTGTGCTCAGCAGTA	0.383			NA											7	43					8.12818e-05	9.4384e-05	0.001984	1	0
CHIT1	1118	broad.mit.edu	37	1	203186907	203186907	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:203186907C>T	uc001gzn.2	-	10	1212	c.1116G>A	c.(1114-1116)CAG>CAA	p.Q372Q	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_Splice_Site_p.G135_splice|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Silent_p.Q363Q	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	372					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						GGTATCGGCCCTGGTTGCAGG	0.597			NA											4	61					0	0	0.000602	0	0
ARF1	375	broad.mit.edu	37	1	228285621	228285621	+	Silent	SNP	G	G	A	rs146827674		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:228285621G>A	uc001hrr.2	+	5	681	c.453G>A	c.(451-453)AGG>AGA	p.R151R	ARF1_uc001hrs.2_Silent_p.R151R|ARF1_uc001hrt.2_Missense_Mutation_p.E73K|ARF1_uc009xev.2_RNA|ARF1_uc001hru.2_Silent_p.R151R|ARF1_uc001hrv.2_Silent_p.R151R|ARF1_uc001hrw.2_Silent_p.R151R	NM_001024226	NP_001019397	P84077	ARF1_HUMAN	ADP-ribosylation factor 1	151					cellular copper ion homeostasis|COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|protein transport|regulation of defense response to virus by virus|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction|viral reproduction	cytosol|Golgi membrane|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding|receptor signaling protein activity				0		Prostate(94;0.0405)				TACGCCACAGGAACTGGTACA	0.617			NA											4	60					0	0	0.009096	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232600659	232600659	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:232600659C>G	uc001hvg.2	-	7	2905	c.2747G>C	c.(2746-2748)AGA>ACA	p.R916T	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	916					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ACATTCTCCTCTTTCGTAAAA	0.413			NA											4	53					0	0	0.000602	0	0
PCNXL2	80003	broad.mit.edu	37	1	233161085	233161085	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:233161085C>A	uc001hvl.2	-	26	4647	c.4412G>T	c.(4411-4413)GGC>GTC	p.G1471V	PCNXL2_uc001hvk.1_Missense_Mutation_p.G123V|PCNXL2_uc001hvm.1_Intron	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1471						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GCAGCAGCAGCCTCTGTCCTC	0.587			NA									OREG0014326	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	81					0.000442599	0.000499047	0.006214	1	0
NID1	4811	broad.mit.edu	37	1	236205225	236205225	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:236205225C>G	uc001hxo.2	-	4	1222	c.1120G>C	c.(1120-1122)GAG>CAG	p.E374Q	NID1_uc009xgd.2_Missense_Mutation_p.E374Q	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	374					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCTGTTTCCTCAACTTCATCC	0.512			NA											11	67					0	0	0.010729	0	0
OR2L13	284521	broad.mit.edu	37	1	248263108	248263108	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:248263108T>C	uc001ids.2	+	3	768	c.431T>C	c.(430-432)ATT>ACT	p.I144T		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GTGAAGATGATTGGAGGCTCT	0.488			NA											26	206					0	0	0.003954	0	0
OR14C36	127066	broad.mit.edu	37	1	248512634	248512634	+	Silent	SNP	T	T	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:248512634T>G	uc010pzl.1	+	1	558	c.558T>G	c.(556-558)TCT>TCG	p.S186S		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGAAGCTCTCTTGCTCTGACA	0.493			NA											10	78					0	0	0.008291	0	0
OR2T2	401992	broad.mit.edu	37	1	248616344	248616344	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:248616344G>T	uc001iek.1	+	1	246	c.246G>T	c.(244-246)ATG>ATT	p.M82I		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCCCCAAGATGCTCCAGGACC	0.527			NA											10	201					3.27435e-08	4.21763e-08	0.00245	1	0
OR2G6	391211	broad.mit.edu	37	1	248685329	248685329	+	Silent	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:248685329C>A	uc001ien.1	+	1	382	c.382C>A	c.(382-384)CGG>AGG	p.R128R		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCTGTCTGCCGGCCACTGCG	0.597			NA											17	57					1.15088e-07	1.45828e-07	0.004007	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37422873	37422873	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:37422873G>A	uc001iza.1	+	5	578	c.479G>A	c.(478-480)GGA>GAA	p.G160E		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	216	ANK 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTATGTCATGGATCATCAGAG	0.378			NA											11	137					0	0	0.001368	0	0
ZNF248	57209	broad.mit.edu	37	10	38121209	38121209	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:38121209C>G	uc001izd.1	-	6	1573	c.1074G>C	c.(1072-1074)GGG>GGC	p.G358G	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Silent_p.G358G	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAATTACTCCCATTTTCAT	0.403			NA											29	89					0	0	0.005443	0	0
C10orf53	282966	broad.mit.edu	37	10	50916560	50916560	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:50916560G>A	uc001jid.1	+	3	431	c.371G>A	c.(370-372)GGA>GAA	p.G124E		NM_182554	NP_872360	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform a	Error:Variant_position_missing_in_Q8N6V4_after_alignment											0		all_neural(218;0.107)				gcccagattggatcatgtatc	0			NA											19	181					0	0	0.007413	0	0
BICC1	80114	broad.mit.edu	37	10	60566792	60566792	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:60566792G>A	uc001jki.1	+	17	2250	c.2250G>A	c.(2248-2250)GAG>GAA	p.E750E	BICC1_uc001jkj.1_Silent_p.E391E	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	750					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TGGTGACGGAGGTCAGAACGC	0.398			NA											7	48					0	0	0.00308	0	0
MYPN	84665	broad.mit.edu	37	10	69926137	69926137	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:69926137C>A	uc001jnm.3	+	11	1872	c.1687C>A	c.(1687-1689)CCC>ACC	p.P563T	MYPN_uc001jnl.1_Missense_Mutation_p.P563T|MYPN_uc001jnn.3_Missense_Mutation_p.P288T|MYPN_uc001jno.3_Missense_Mutation_p.P563T|MYPN_uc009xps.2_Missense_Mutation_p.P563T|MYPN_uc009xpt.2_Missense_Mutation_p.P563T|MYPN_uc010qit.1_Missense_Mutation_p.P269T|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	563						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						GCCCTCCCCACCCCACTCAGA	0.572			NA											11	42					5.16669e-11	6.90667e-11	0.010729	1	0
COL13A1	1305	broad.mit.edu	37	10	71707089	71707089	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:71707089G>A	uc001jpr.1	+	36	2552	c.2016G>A	c.(2014-2016)AAG>AAA	p.K672K	COL13A1_uc001jqj.1_Silent_p.K645K|COL13A1_uc001jps.1_Silent_p.K643K|COL13A1_uc001jpt.1_Silent_p.K631K|COL13A1_uc001jpu.1_Silent_p.K641K|COL13A1_uc001jpv.1_Silent_p.K646K|COL13A1_uc001jpx.1_Silent_p.K623K|COL13A1_uc001jpw.1_Silent_p.K619K|COL13A1_uc001jpy.1_Silent_p.K610K|COL13A1_uc001jpz.1_Silent_p.K615K|COL13A1_uc001jqa.1_Silent_p.K612K|COL13A1_uc001jqc.1_Silent_p.K657K|COL13A1_uc001jqb.1_Silent_p.K594K|COL13A1_uc001jql.2_Silent_p.K672K|COL13A1_uc001jqd.1_Silent_p.K660K|COL13A1_uc001jqe.1_Silent_p.K655K|COL13A1_uc001jqf.1_Silent_p.K653K|COL13A1_uc001jqg.1_Silent_p.K650K|COL13A1_uc001jqh.1_Silent_p.K660K|COL13A1_uc001jqi.1_Silent_p.K658K|COL13A1_uc010qjf.1_Silent_p.K447K	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	672	Extracellular (Potential).|Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	CCGGGGACAAGGGAAACCGGG	0.527			NA											6	48					0	0	0.001984	0	0
H2AFY2	55506	broad.mit.edu	37	10	71851671	71851671	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:71851671G>A	uc001jqm.2	+	4	897	c.438G>A	c.(436-438)GGG>GGA	p.G146G	H2AFY2_uc001jqn.2_RNA	NM_018649	NP_061119	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	146	Lys-rich.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			skin(1)	1						AGAAGGGGGGGAAGAAATCCA	0.537			NA											4	44					0	0	0.000602	0	0
SGPL1	8879	broad.mit.edu	37	10	72633268	72633268	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:72633268C>T	uc001jrm.2	+	12	1442	c.1220C>T	c.(1219-1221)GCC>GTC	p.A407V	SGPL1_uc009xqk.2_RNA	NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	407	Cytoplasmic (Potential).				apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	TGTTGGGCTGCCTTGATGCAC	0.522	Colon(151;1054 2458 6676 40971)		NA											6	114					0	0	0.001168	0	0
SEC24C	9632	broad.mit.edu	37	10	75525632	75525632	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:75525632C>T	uc001juw.2	+	11	1620	c.1441C>T	c.(1441-1443)CTG>TTG	p.L481L	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Silent_p.L339L|SEC24C_uc001jux.2_Silent_p.L481L|SEC24C_uc010qko.1_Silent_p.L362L|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	481					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					TGAGCTATCCCTGGGCTCTTA	0.517			NA											28	141					0	0	0.007291	0	0
GHITM	27069	broad.mit.edu	37	10	85909813	85909813	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:85909813G>T	uc001kcs.1	+	7	799	c.595G>T	c.(595-597)GTG>TTG	p.V199L	GHITM_uc010qma.1_Missense_Mutation_p.V130L|GHITM_uc010qmb.1_Missense_Mutation_p.V129L	NM_014394	NP_055209	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	199	Helical; (Potential).				apoptosis	integral to membrane|mitochondrial inner membrane					0						TTCTCCAGGTGTGATGGGTGC	0.433			NA											17	62					3.5997e-14	4.96554e-14	0.002299	1	0
MYOF	26509	broad.mit.edu	37	10	95111578	95111578	+	Silent	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:95111578G>C	uc001kin.2	-	33	3630	c.3507C>G	c.(3505-3507)CTC>CTG	p.L1169L	MYOF_uc001kio.2_Silent_p.L1156L|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1169	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TGCTCCGATGGAGGAAACAGA	0.433			NA											5	38					0	0	0.001168	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115609007	115609007	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr10:115609007C>G	uc001law.2	-	2	2775	c.1857G>C	c.(1855-1857)GAG>GAC	p.E619D		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	619					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		AAAGCTGACTCTCATGTAAAG	0.403			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					9	86					0	0	0.008291	0	0
NUP98	4928	broad.mit.edu	37	11	3733881	3733881	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:3733881C>G	uc001lyh.2	-	20	2946	c.2655G>C	c.(2653-2655)AAG>AAC	p.K885N	NUP98_uc001lyi.2_Missense_Mutation_p.K885N|NUP98_uc001lyj.1_Missense_Mutation_p.K885N|NUP98_uc001lyk.1_Missense_Mutation_p.K902N	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	902					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCTTCAACTTCTTTGTACTAG	0.478			NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								9	109					0	0	0.008291	0	0
OR52E8	390079	broad.mit.edu	37	11	5878756	5878756	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:5878756C>A	uc010qzr.1	-	1	177	c.177G>T	c.(175-177)CAG>CAT	p.Q59H	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	59	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATGGAGACTCTGCTCAGTCT	0.468			NA											21	117					1.64113e-05	1.97647e-05	0.010504	1	0
BTBD10	84280	broad.mit.edu	37	11	13435091	13435091	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:13435091T>G	uc001mkz.2	-	6	1051	c.794A>C	c.(793-795)AAA>ACA	p.K265T	BTBD10_uc010rcl.1_Missense_Mutation_p.K273T|BTBD10_uc001mla.2_Missense_Mutation_p.K249T|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.K217T|BTBD10_uc010rcn.1_Missense_Mutation_p.K234T|BTBD10_uc009ygo.2_Missense_Mutation_p.K217T	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	265						nucleus					0				Epithelial(150;0.0214)		ATCTCTACATTTAATAGTGCT	0.323			NA											3	44					0	0	0.009096	0	0
PDE3B	5140	broad.mit.edu	37	11	14865513	14865513	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:14865513C>A	uc001mln.2	+	12	2814	c.2461C>A	c.(2461-2463)CAT>AAT	p.H821N	PDE3B_uc010rcr.1_Missense_Mutation_p.H770N	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	821	Catalytic (By similarity).	Divalent metal cation 1.			cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						AGCTGCCATGCATGATTATGA	0.418			NA											23	62					1.42536e-11	1.93193e-11	0.004656	1	0
KCNA4	3739	broad.mit.edu	37	11	30033664	30033664	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:30033664C>A	uc001msk.2	-	2	1714	c.562G>T	c.(562-564)GAG>TAG	p.E188*		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	188						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATTTGGGTCTCAAAGCGTAGG	0.498			NA											15	39					1.3612e-06	1.69714e-06	0.003163	1	0
KCNA4	3739	broad.mit.edu	37	11	30033840	30033840	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:30033840T>G	uc001msk.2	-	2	1538	c.386A>C	c.(385-387)GAG>GCG	p.E129A		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	129	Poly-Glu.					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ttcctcctcctcctcatcttc	0.413			NA											6	41					0	0	0.001168	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137205	40137206	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:40137205_40137206GG>TT	uc001mxa.1	-	2	2601_2602	c.637_638CC>AA	c.(637-639)CCT>AAT	p.P213N	LRRC4C_uc001mxc.1_Missense_Mutation_p.P209N|LRRC4C_uc001mxd.1_Missense_Mutation_p.P209N|LRRC4C_uc001mxb.1_Missense_Mutation_p.P209N	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	213	LRR 6.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGTGAGGTTAGGGATTTCCCGA	0.455			NA											7	38					0	0	0.004672	0	0
OR4A5	81318	broad.mit.edu	37	11	51411644	51411644	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:51411644C>A	uc001nhi.1	-	1	752	c.752G>T	c.(751-753)TGT>TTT	p.C251F		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				TATGAAAATACAGGGTACAAA	0.388			NA											6	30					0.00116845	0.00129864	0.001168	1	0
OR5L1	219437	broad.mit.edu	37	11	55579362	55579362	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:55579362G>T	uc001nhw.1	+	1	420	c.420G>T	c.(418-420)GTG>GTT	p.V140V		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CTTGGAAGGTGCGTGTGGAGC	0.502			NA											14	106					0.000151284	0.000174111	0.001855	1	0
OR5J2	282775	broad.mit.edu	37	11	55944298	55944298	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:55944298G>T	uc010rjb.1	+	1	205	c.205G>T	c.(205-207)GTG>TTG	p.V69L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TCTTTCATTTGTGGATGCCTG	0.443			NA											10	147					0.000442599	0.000499047	0.006214	1	0
OR5M3	219482	broad.mit.edu	37	11	56237626	56237626	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:56237626C>A	uc010rjk.1	-	1	348	c.348G>T	c.(346-348)ATG>ATT	p.M116I		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TATCAAAGGCCATCGCAGCAA	0.358			NA											5	71					0.000602214	0.000673165	0.000602	1	0
OR5B21	219968	broad.mit.edu	37	11	58275352	58275352	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:58275352G>A	uc010rki.1	-	1	227	c.227C>T	c.(226-228)GCC>GTC	p.A76V		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CGTTTTGGGGGCTACAGCTGA	0.507			NA											6	54					0	0	0.00308	0	0
TM7SF2	7108	broad.mit.edu	37	11	64883032	64883032	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:64883032G>C	uc001oct.2	+	9	1205	c.1058G>C	c.(1057-1059)GGA>GCA	p.G353A	TM7SF2_uc010rny.1_Missense_Mutation_p.G237A|TM7SF2_uc001ocu.2_Missense_Mutation_p.G326A|TM7SF2_uc001ocv.2_Missense_Mutation_p.G374A|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	353					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						AACTATCTTGGAGACCTCATC	0.592			NA											3	50					0	0	0.004672	0	0
PACS1	55690	broad.mit.edu	37	11	65983614	65983614	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:65983614G>T	uc001oha.1	+	5	819	c.685G>T	c.(685-687)GCA>TCA	p.A229S	PACS1_uc001ogz.1_Missense_Mutation_p.A229S	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	229					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TAATGAAGGCGCACTGGTGCT	0.537			NA											13	58					2.61681e-11	3.52229e-11	0.00245	1	0
BBS1	582	broad.mit.edu	37	11	66282012	66282012	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:66282012C>T	uc001oij.1	+	4	307	c.295C>T	c.(295-297)CCC>TCC	p.P99S	BBS1_uc001oii.1_Missense_Mutation_p.P136S|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Missense_Mutation_p.P99S|BBS1_uc001oik.1_Missense_Mutation_p.P23S|BBS1_uc001oil.1_Missense_Mutation_p.P99S	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	99					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						GCAACATGAGCCCCGGACCCC	0.572	GBM(152;173 2612 9770 10137)		NA							Bardet-Biedl_syndrome				13	184					0	0	0.001855	0	0
CLPB	81570	broad.mit.edu	37	11	72145270	72145270	+	Silent	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:72145270G>C	uc001osj.2	-	1	299	c.249C>G	c.(247-249)CTC>CTG	p.L83L	CLPB_uc010rqx.1_Missense_Mutation_p.R3G|CLPB_uc010rqy.1_Silent_p.L83L|CLPB_uc001osk.2_Silent_p.L83L|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_5'UTR	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	83					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						TGGCAGCCGCGAGGCATTTGG	0.692			NA									OREG0021194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	69					0	0	0.006214	0	0
RNF169	254225	broad.mit.edu	37	11	74547638	74547638	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:74547638C>T	uc001ovl.3	+	6	2003	c.1990C>T	c.(1990-1992)CAG>TAG	p.Q664*	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	664							zinc ion binding			ovary(1)	1						GCAGAAGCTTCAGCAAGAGGA	0.537			NA											6	75					0	0	0.001168	0	0
FAT3	120114	broad.mit.edu	37	11	92086102	92086102	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:92086102C>A	uc001pdj.3	+	1	841	c.824C>A	c.(823-825)TCG>TAG	p.S275*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	275	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTTCCTTTCTCGTTGGAAAAA	0.448			NA								TCGA Ovarian(4;0.039)			13	102					0.00010058	0.0001161	0.001368	1	0
C11orf54	28970	broad.mit.edu	37	11	93488502	93488502	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:93488502C>T	uc009ywi.2	+	7	788	c.457C>T	c.(457-459)CAG>TAG	p.Q153*	C11orf54_uc001pee.1_Intron|C11orf54_uc001pef.2_Nonsense_Mutation_p.Q153*|C11orf54_uc001peg.2_Nonsense_Mutation_p.Q153*|C11orf54_uc001peh.2_Nonsense_Mutation_p.Q153*|C11orf54_uc001pei.2_Nonsense_Mutation_p.Q134*|C11orf54_uc001pej.2_Nonsense_Mutation_p.Q134*|C11orf54_uc001pek.2_Nonsense_Mutation_p.Q42*	NM_014039	NP_054758	Q9H0W9	CK054_HUMAN	hypothetical protein LOC28970	153						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TCATGATTTTCAGTGTGCATT	0.423			NA											4	42					0	0	0.009096	0	0
TRPC6	7225	broad.mit.edu	37	11	101344457	101344457	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:101344457G>C	uc001pgk.3	-	7	2217	c.1792C>G	c.(1792-1794)CTT>GTT	p.L598V	TRPC6_uc009ywy.2_Missense_Mutation_p.L482V|TRPC6_uc009ywz.1_Missense_Mutation_p.L543V	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	598	Helical; (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ATTGCATAAAGACCTTCAGAT	0.363	Colon(166;1315 1927 11094 12848 34731)		NA											3	59					0	0	0.004672	0	0
HYOU1	10525	broad.mit.edu	37	11	118925964	118925964	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:118925964C>A	uc001puu.2	-	5	545	c.352G>T	c.(352-354)GCC>TCC	p.A118S	HYOU1_uc001put.2_Missense_Mutation_p.A83S|HYOU1_uc010ryu.1_Missense_Mutation_p.A138S|HYOU1_uc010ryv.1_Intron|HYOU1_uc001pux.3_Missense_Mutation_p.A118S|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.A118S	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	118						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GGGAAGCGGGCCTGGTAAAGA	0.567			NA											16	102					8.60227e-14	1.18243e-13	0.004007	1	0
ABCG4	64137	broad.mit.edu	37	11	119027683	119027683	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:119027683G>A	uc001pvs.2	+	9	1363	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K	ABCG4_uc009zar.2_Missense_Mutation_p.E343K	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	343	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GAGCAGCCCTGAGAAGAACGA	0.607			NA											8	104					0	0	0.006214	0	0
TECTA	7007	broad.mit.edu	37	11	121032845	121032845	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:121032845G>T	uc010rzo.1	+	15	5038	c.5038G>T	c.(5038-5040)GTG>TTG	p.V1680L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1680	VWFD 4.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GTGTGACAATGTGCACATCCA	0.537			NA											10	93					2.17888e-05	2.592e-05	0.006214	1	0
CRTAM	56253	broad.mit.edu	37	11	122738175	122738175	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:122738175G>T	uc001pyj.2	+	8	876	c.876G>T	c.(874-876)ACG>ACT	p.T292T	CRTAM_uc001pyk.2_Silent_p.T93T	NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated	292	Helical; (Potential).				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGCTGCTCACGCTGGTGTCCT	0.418			NA											3	20					0.004672	0.00511946	0.004672	1	0
OR10G4	390264	broad.mit.edu	37	11	123886957	123886957	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:123886957C>T	uc010sac.1	+	1	676	c.676C>T	c.(676-678)CGG>TGG	p.R226W		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TTCCATCCTGCGGATCCGCAC	0.517			NA											5	97					0	0	0.001984	0	0
IGSF9B	22997	broad.mit.edu	37	11	133791250	133791250	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr11:133791250G>A	uc001qgx.3	-	18	2601	c.2370C>T	c.(2368-2370)CTC>CTT	p.L790L		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	790	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		ACGGCGCTCGGAGCGTGCGGA	0.657			NA											4	34					0	0	0.009096	0	0
WNK1	65125	broad.mit.edu	37	12	992609	992609	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:992609C>G	uc001qio.3	+	16	4045	c.3538C>G	c.(3538-3540)CAA>GAA	p.Q1180E	WNK1_uc001qip.3_Missense_Mutation_p.Q933E|WNK1_uc001qir.3_Missense_Mutation_p.Q353E	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1180					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTTTGTGGATCAAGTGCGAGA	0.388	Colon(19;451 567 6672 12618 28860)		NA											3	39					0	0	0.004672	0	0
WNK1	65125	broad.mit.edu	37	12	1006841	1006841	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:1006841C>T	uc001qio.3	+	25	6949	c.6442C>T	c.(6442-6444)CTT>TTT	p.L2148F	WNK1_uc001qip.3_Missense_Mutation_p.L1900F|WNK1_uc001qir.3_Missense_Mutation_p.L1321F|WNK1_uc009zdm.1_5'Flank|WNK1_uc009zdn.1_5'Flank	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2148					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AAGCCCCCAGCTTTCAGGTAA	0.488	Colon(19;451 567 6672 12618 28860)		NA											3	25					0	0	0.004672	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6436574	6436574	+	Missense_Mutation	SNP	C	C	T	rs71584817	byFrequency	TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:6436574C>T	uc001qnr.2	+	15	1973	c.1825C>T	c.(1825-1827)CGC>TGC	p.R609C	PLEKHG6_uc010sew.1_Missense_Mutation_p.R609C|PLEKHG6_uc010sex.1_Missense_Mutation_p.R577C	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	609					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						GAGCCGTCTACGCCAAAGAGC	0.647			NA											6	156					0	0	0.001984	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48132935	48132935	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:48132935G>A	uc009zkp.2	-	23	2766	c.2326C>T	c.(2326-2328)CTT>TTT	p.L776F	uc001rpv.2_Intron|RAPGEF3_uc001rpw.2_Missense_Mutation_p.L111F|RAPGEF3_uc001rpx.2_Missense_Mutation_p.L233F|RAPGEF3_uc010sln.1_Missense_Mutation_p.L273F|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Missense_Mutation_p.L776F|RAPGEF3_uc001rpz.3_Missense_Mutation_p.L818F	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	776					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CCTTTGAGAAGAAGGGGCATG	0.348			NA											6	28					0	0	0.00308	0	0
COL2A1	1280	broad.mit.edu	37	12	48372469	48372469	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:48372469C>T	uc001rqu.2	-	42	2987	c.2806G>A	c.(2806-2808)GGC>AGC	p.G936S	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.G867S	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	936	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CCAGGGGGGCCGCTGTCTCCT	0.637			NA											6	33					0	0	0.001984	0	0
RHEBL1	121268	broad.mit.edu	37	12	49460259	49460259	+	Missense_Mutation	SNP	C	C	T	rs148047837		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:49460259C>T	uc001rtc.1	-	5	539	c.332G>A	c.(331-333)CGG>CAG	p.R111Q	RHEBL1_uc001rtd.1_Missense_Mutation_p.R107Q|RHEBL1_uc009zlc.1_RNA	NM_144593	NP_653194	Q8TAI7	REBL1_HUMAN	Ras homolog enriched in brain like 1 precursor	111					positive regulation of NF-kappaB transcription factor activity|small GTPase mediated signal transduction|TOR signaling cascade	cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding			lung(1)|breast(1)	2						GGCCACTTACCGGGTTTTCCC	0.483			NA											14	457					0	0	0.004007	0	0
KRT7	3855	broad.mit.edu	37	12	52635264	52635264	+	Silent	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:52635264A>T	uc001saa.1	+	5	829	c.702A>T	c.(700-702)ACA>ACT	p.T234T	KRT7_uc009zmf.1_Silent_p.T234T	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	234	Rod.|Coil 1B.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		AGGAGTTGACAGAGCTGCAGT	0.577			NA											4	64					0	0	0.001168	0	0
LRP1	4035	broad.mit.edu	37	12	57590912	57590912	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:57590912C>T	uc001snd.2	+	56	9506	c.9040C>T	c.(9040-9042)CGC>TGC	p.R3014C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3014	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTATGCACCCCGCGGCGGCGA	0.637			NA											9	72					0	0	0.004482	0	0
SRGAP1	57522	broad.mit.edu	37	12	64437229	64437229	+	Silent	SNP	A	A	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:64437229A>G	uc010ssp.1	+	6	731	c.675A>G	c.(673-675)AGA>AGG	p.R225R	SRGAP1_uc001srt.2_Silent_p.R225R|SRGAP1_uc001srv.2_Silent_p.R185R	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	225					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CATTCCAGAGACAAGCAAAAT	0.333			NA											4	21					0	0	0.009096	0	0
SELPLG	6404	broad.mit.edu	37	12	109017937	109017937	+	Silent	SNP	T	T	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:109017937T>C	uc001tni.2	-	2	307	c.147A>G	c.(145-147)CTA>CTG	p.L49L	SELPLG_uc001tnh.2_Silent_p.L49L|SELPLG_uc010sxe.1_Silent_p.L65L	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	49	Extracellular (Potential).			YEYLDY->FEFLDF: No sulfation. Almost complete loss of P-selectin binding. No effect on E-selectin binding.|YEYLDYD->FEFLDFE: No sulfation. Almost complete loss of P-selectin binding. No effect on E-selectin binding.	blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						AATCATAATCTAGGTACTCAT	0.572			NA											3	54					0	0	0.009096	0	0
TBX5	6910	broad.mit.edu	37	12	114793577	114793577	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:114793577C>G	uc001tvo.2	-	9	1812	c.1317G>C	c.(1315-1317)CTG>CTC	p.L439L	TBX5_uc001tvp.2_Silent_p.L439L|TBX5_uc001tvq.2_Silent_p.L389L	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	439				MDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQ TS -> WTGYPTSTSPLTSPRGPWSLGWLAWQPWLPTAGRG NVPSTRPP (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CCATGCCAGCCAGCCGAGGGA	0.662	NSCLC(152;1358 1980 4050 23898 40356)		NA											4	28					0	0	0.009096	0	0
RFC5	5985	broad.mit.edu	37	12	118467620	118467620	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:118467620G>A	uc001twq.2	+	10	1041	c.916G>A	c.(916-918)GCA>ACA	p.A306T	RFC5_uc010syx.1_Missense_Mutation_p.A285T|RFC5_uc010syy.1_Missense_Mutation_p.A285T|RFC5_uc010syz.1_Missense_Mutation_p.A221T|RFC5_uc009zwr.2_Missense_Mutation_p.A303T	NM_007370	NP_031396	P40937	RFC5_HUMAN	replication factor C 5 isoform 1	306					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACCAAAATGGCAGACATTGA	0.358			NA											10	99					0	0	0.001855	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124235710	124235710	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr12:124235710C>T	uc001ufr.2	+	16	2237	c.1989C>T	c.(1987-1989)CTC>CTT	p.L663L		NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	663	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TCCCTGTCCTCTTCTTGGGAA	0.502			NA											19	126					0	0	0.006122	0	0
ZMYM5	9205	broad.mit.edu	37	13	20409647	20409647	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr13:20409647G>A	uc010tcn.1	-	7	1486	c.1221C>T	c.(1219-1221)TGC>TGT	p.C407C	ZMYM5_uc001umm.1_Silent_p.C231C	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	407	MYM-type 4.					nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		AACTTTGGCAGCAAAATCTCT	0.373			NA											3	47					0	0	0.004672	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895869	24895869	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr13:24895869C>A	uc001upj.2	+	4	1026	c.965C>A	c.(964-966)ACA>AAA	p.T322K	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	322	C1q.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		GACGATGACACAACTTTCACA	0.517			NA											16	172					0.000422831	0.000479538	0.004007	1	0
FREM2	341640	broad.mit.edu	37	13	39266294	39266294	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr13:39266294A>C	uc001uwv.2	+	1	5122	c.4813A>C	c.(4813-4815)AAA>CAA	p.K1605Q		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1605	Extracellular (Potential).|CSPG 11.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AATCAGCTACAAACATGATGG	0.418			NA											4	67					0	0	0.009096	0	0
NEK3	4752	broad.mit.edu	37	13	52707317	52707317	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr13:52707317C>T	uc001vgi.2	-	18	1717	c.1482G>A	c.(1480-1482)CTG>CTA	p.L494L	NEK3_uc001vgg.2_Silent_p.L471L|NEK3_uc001vgh.2_Silent_p.L498L|NEK3_uc010tgx.1_RNA|NEK3_uc010tgy.1_Silent_p.L477L	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a	494					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		CTCGCTTCTTCAGCTCTGACA	0.498			NA											5	17					0	0	0.000602	0	0
PCDH9	5101	broad.mit.edu	37	13	67801390	67801390	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr13:67801390C>A	uc001vik.2	-	2	1875	c.1183G>T	c.(1183-1185)GTG>TTG	p.V395L	PCDH9_uc001vil.2_Missense_Mutation_p.V395L|PCDH9_uc010thl.1_Missense_Mutation_p.V395L|PCDH9_uc001vin.3_Missense_Mutation_p.V395L	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	395	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTGCCATTCACATCTGTGTCC	0.373			NA											4	82					0.00909568	0.00980116	0.009096	1	0
CARKD	55739	broad.mit.edu	37	13	111290831	111290831	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr13:111290831A>T	uc001vrb.2	+	10	1014	c.1000A>T	c.(1000-1002)ATC>TTC	p.I334F	CARKD_uc010tjj.1_Missense_Mutation_p.I316F|CARKD_uc001vqz.2_RNA|CARKD_uc001vra.2_RNA|CARKD_uc010tjk.1_Missense_Mutation_p.I224F|CARKD_uc010tjl.1_Missense_Mutation_p.I203F|CARKD_uc001vrc.2_Missense_Mutation_p.D379V			Q8IW45	CARKD_HUMAN	RecName: Full=Carbohydrate kinase domain-containing protein; Flags: Precursor;	334	YjeF C-terminal.									skin(1)	1						CTCCGACATGATCGCCGAGGT	0.632			NA											15	64					0	0	0.004007	0	0
PARP2	10038	broad.mit.edu	37	14	20815046	20815046	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:20815046G>C	uc001vxc.2	+	4	365	c.337G>C	c.(337-339)GAT>CAT	p.D113H	PARP2_uc001vxd.2_Missense_Mutation_p.D100H|PARP2_uc001vxb.1_Missense_Mutation_p.D113H	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	113					protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		TGAAGGAAATGATGTCTATGA	0.368			NA						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					5	40					0	0	0.001168	0	0
OR4E2	26686	broad.mit.edu	37	14	22133768	22133768	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:22133768G>T	uc010tmd.1	+	1	472	c.472G>T	c.(472-474)GGG>TGG	p.G158W		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TCACTCACTAGGGCAGACCTT	0.488			NA											15	114					2.32078e-09	3.06029e-09	0.003163	1	0
FERMT2	10979	broad.mit.edu	37	14	53325133	53325133	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:53325133C>T	uc001xad.2	-	15	2060	c.2005G>A	c.(2005-2007)GAA>AAA	p.E669K	FERMT2_uc001xac.2_Missense_Mutation_p.E676K|FERMT2_uc001xae.2_Missense_Mutation_p.E669K	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	669					actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					AACATCTCTTCATCTAAACTC	0.363			NA											9	60					0	0	0.010729	0	0
PRKCH	5583	broad.mit.edu	37	14	61997242	61997242	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:61997242G>A	uc001xfn.2	+	12	1995	c.1690G>A	c.(1690-1692)GAG>AAG	p.E564K	PRKCH_uc010tsa.1_Missense_Mutation_p.E403K|PRKCH_uc010tsb.1_Missense_Mutation_p.E132K	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	564	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TGACCTCTTTGAGGCCATACT	0.522	Melanoma(135;863 1779 8064 14443 26348)		NA											12	86					0	0	0.001855	0	0
KCNH5	27133	broad.mit.edu	37	14	63174541	63174541	+	Silent	SNP	C	C	A	rs143147156	byFrequency	TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:63174541C>A	uc001xfx.2	-	11	2703	c.2652G>T	c.(2650-2652)CCG>CCT	p.P884P	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	884	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGTGCTCTAGCGGACTTCGGG	0.502			NA											16	100					4.7546e-09	6.20651e-09	0.004007	1	0
ESRRB	2103	broad.mit.edu	37	14	76948464	76948464	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:76948464A>T	uc001xsq.1	+	4	687	c.620A>T	c.(619-621)AAG>ATG	p.K207M	ESRRB_uc001xsr.2_Missense_Mutation_p.K207M|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	207						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CCTGCTAAAAAGCCATGTGAG	0.542			NA											5	42					0	0	0.000602	0	0
ADCK1	57143	broad.mit.edu	37	14	78353523	78353523	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr14:78353523G>T	uc001xui.2	+	5	612	c.513G>T	c.(511-513)CGG>CGT	p.R171R	ADCK1_uc010tvo.1_Intron|ADCK1_uc001xuj.2_Silent_p.R103R|ADCK1_uc001xuk.1_Silent_p.R45R	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	178	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		ATGATGGGCGGACGGTGGCCG	0.607			NA											8	98					0.000157383	0.000180065	0.00308	1	0
RYR3	6263	broad.mit.edu	37	15	34151830	34151830	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:34151830G>C	uc001zhi.2	+	100	14267	c.14197G>C	c.(14197-14199)GAA>CAA	p.E4733Q	RYR3_uc010bar.2_Missense_Mutation_p.E4728Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4733					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATTGGTGATGAAATTGAAGA	0.423			NA											4	41					0	0	0.009096	0	0
GPR176	11245	broad.mit.edu	37	15	40093560	40093561	+	Nonsense_Mutation	DNP	CC	CC	AT			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:40093560_40093561CC>AT	uc001zkj.1	-	3	2186_2187	c.1320_1321GG>AT	c.(1318-1323)GTGGAA>GTATAA	p.E441*	GPR176_uc010uck.1_Nonsense_Mutation_p.E381*	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	441	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		GTTTCAGGTTCCACAGGGGCTG	0.594			NA											6	140					0	0	0.004672	0	0
MGA	23269	broad.mit.edu	37	15	42041375	42041375	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:42041375C>T	uc010ucy.1	+	17	5751	c.5570C>T	c.(5569-5571)TCG>TTG	p.S1857L	MGA_uc010ucz.1_Missense_Mutation_p.S1648L|MGA_uc010uda.1_Missense_Mutation_p.S473L|MGA_uc001zoi.2_Missense_Mutation_p.S71L	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1818						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCTTCCACTTCGTCCTCTGCT	0.443			NA											6	81					0	0	0.001984	0	0
MGA	23269	broad.mit.edu	37	15	42041491	42041491	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:42041491C>T	uc010ucy.1	+	17	5867	c.5686C>T	c.(5686-5688)CAG>TAG	p.Q1896*	MGA_uc010ucz.1_Nonsense_Mutation_p.Q1687*|MGA_uc010uda.1_Nonsense_Mutation_p.Q512*|MGA_uc001zoi.2_Nonsense_Mutation_p.Q110*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1857						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TTTTGTGTCTCAGGCTGGTAC	0.438			NA											5	51					0	0	0.000602	0	0
C2CD4A	145741	broad.mit.edu	37	15	62360140	62360140	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:62360140G>C	uc002ahf.3	+	2	469	c.328G>C	c.(328-330)GAG>CAG	p.E110Q		NM_207322	NP_997205	Q8NCU7	C2C4A_HUMAN	nuclear localized factor 1	110						nucleus					0						CGCGCTGCTCGAGAGCCCGCA	0.517			NA											2	9					0	0	0.004672	0	0
DIS3L	115752	broad.mit.edu	37	15	66621441	66621441	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:66621441G>A	uc010ujm.1	+	13	2350	c.2335G>A	c.(2335-2337)GAG>AAG	p.E779K	DIS3L_uc002app.2_Missense_Mutation_p.E696K|DIS3L_uc010bho.2_Missense_Mutation_p.E645K	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	779					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						ATCCTGTGCGGAGGAGGAGTT	0.468			NA											5	61					0	0	0.000602	0	0
LOXL1	4016	broad.mit.edu	37	15	74219600	74219600	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:74219600C>G	uc002awc.1	+	1	812	c.476C>G	c.(475-477)TCG>TGG	p.S159W	uc002awa.1_Intron|uc002awb.1_Intron	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	159					protein deamination	extracellular space	copper ion binding				0						TCCTCGGTCTCGGCTTCGGCC	0.711			NA											7	76					0	0	0.00308	0	0
FSD2	123722	broad.mit.edu	37	15	83456108	83456108	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:83456108T>G	uc002bjd.2	-	2	202	c.35A>C	c.(34-36)GAC>GCC	p.D12A	FSD2_uc010uol.1_Missense_Mutation_p.D12A|FSD2_uc010uom.1_Missense_Mutation_p.D12A	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	12										central_nervous_system(1)	1						AGTAGACCTGTCCAGCCCCAG	0.468			NA											6	64					0	0	0.001168	0	0
ZNF592	9640	broad.mit.edu	37	15	85345225	85345225	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr15:85345225G>A	uc002bld.2	+	11	3741	c.3405G>A	c.(3403-3405)TCG>TCA	p.S1135S	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	1135	C2H2-type 12; atypical.				cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCACAGACTCGGGGCTCGAGT	0.562			NA											5	43					0	0	0.000602	0	0
SOX8	30812	broad.mit.edu	37	16	1034985	1034985	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:1034985C>A	uc002ckn.2	+	3	1055	c.940C>A	c.(940-942)CCC>ACC	p.P314T		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	314					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				CGGGGCGTCCCCCGTGTGGGC	0.756			NA											5	11					1.23904e-05	1.49685e-05	0.000602	1	0
ADCY9	115	broad.mit.edu	37	16	4164189	4164189	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:4164189G>A	uc002cvx.2	-	2	1794	c.1255C>T	c.(1255-1257)CTG>TTG	p.L419L		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	419	Cytoplasmic (Potential).|Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						AGATCGTTCAGGAGACCCACC	0.532			NA											10	65					0	0	0.006214	0	0
SEC14L5	9717	broad.mit.edu	37	16	5038216	5038216	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:5038216C>G	uc002cye.2	+	4	460	c.280C>G	c.(280-282)CTC>GTC	p.L94V		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	94	PRELI/MSF1.					integral to membrane|intracellular	transporter activity				0						GAGGACGCTCCTCATCGAAGC	0.632			NA											5	38					0	0	0.000602	0	0
ABCC6	368	broad.mit.edu	37	16	16302622	16302622	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:16302622C>G	uc002den.3	-	7	794	c.757G>C	c.(757-759)GAA>CAA	p.E253Q	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Missense_Mutation_p.E265Q	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	253	Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CACTCCTTTTCAAGCCGGGAA	0.507			NA											9	85					0	0	0.004482	0	0
KCTD19	146212	broad.mit.edu	37	16	67325290	67325290	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:67325290G>T	uc002esu.2	-	14	2538	c.2487C>A	c.(2485-2487)GAC>GAA	p.D829E	KCTD19_uc002est.2_Missense_Mutation_p.D601E|KCTD19_uc010vjj.1_Missense_Mutation_p.D572E	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	829						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCATGATGATGTCAGCCAGGA	0.517			NA											4	47					0.000602214	0.000673165	0.000602	1	0
GAN	8139	broad.mit.edu	37	16	81399073	81399073	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:81399073G>A	uc002fgo.2	+	9	1640	c.1492G>A	c.(1492-1494)GAG>AAG	p.E498K		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	498	Kelch 5.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				CTACCATGATGAGTTTAAAAG	0.428	GBM(106;1239 1507 7582 9741 33976)		NA											9	86					0	0	0.004482	0	0
OSGIN1	29948	broad.mit.edu	37	16	83999139	83999139	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr16:83999139G>C	uc002fha.2	+	7	1593	c.1210G>C	c.(1210-1212)GAC>CAC	p.D404H	OSGIN1_uc002fhb.2_Missense_Mutation_p.D321H|OSGIN1_uc002fhc.2_Missense_Mutation_p.D321H	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	404					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						GGCCGTGGACGACCCTGGCCT	0.652			NA											4	46					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7573991	7573991	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:7573991C>A	uc002gim.2	-	10	1230	c.1036G>T	c.(1036-1038)GAG>TAG	p.E346*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.E214*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.E346*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	346	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		E -> A (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L344fs*23(2)|p.L344fs*22(1)|p.E346A(1)|p.?(1)|p.E346*(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCAAGGCCTCATTCAGCTCT	0.542	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	49					1.58986e-06	1.96961e-06	0.008291	1	0
MYH1	4619	broad.mit.edu	37	17	10419566	10419566	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:10419566G>A	uc002gmo.2	-	4	392	c.298C>T	c.(298-300)CCT>TCT	p.P100S	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	100	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AGCACAGCAGGCTCGTGTAGA	0.463			NA											17	110					0	0	0.00499	0	0
ATAD5	79915	broad.mit.edu	37	17	29205039	29205039	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:29205039G>A	uc002hfs.1	+	17	4283	c.3937G>A	c.(3937-3939)GAA>AAA	p.E1313K		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1313					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AATTTTTGATGAAGATGCTGG	0.284			NA											7	84					0	0	0.001984	0	0
C17orf50	146853	broad.mit.edu	37	17	34091593	34091593	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:34091593G>A	uc002hjx.2	+	3	526	c.481G>A	c.(481-483)GAT>AAT	p.D161N	MMP28_uc002hjw.1_Intron	NM_145272	NP_660315	Q8WW18	CQ050_HUMAN	hypothetical protein LOC146853	161											0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGCGTTCTGGATCACCCGGA	0.662			NA											12	23					0	0	0.003163	0	0
CCL16	6360	broad.mit.edu	37	17	34304721	34304721	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:34304721C>T	uc002hkl.2	-	3	311	c.244G>A	c.(244-246)GAC>AAC	p.D82N	CCL16_uc002hkm.2_RNA	NM_004590	NP_004581	O15467	CCL16_HUMAN	small inducible cytokine A16 precursor	82					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGACCCAGTCGTCATTGGGG	0.522			NA											8	110					0	0	0.004482	0	0
TNS4	84951	broad.mit.edu	37	17	38643291	38643291	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:38643291C>A	uc010cxb.2	-	4	1449	c.1285G>T	c.(1285-1287)GAG>TAG	p.E429*		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	429					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GACGTACCCTCTGGGCATGTG	0.458			NA											23	347					2.39556e-15	3.32812e-15	0.00278	1	0
DBF4B	80174	broad.mit.edu	37	17	42818707	42818707	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:42818707G>C	uc002ihf.2	+	10	930	c.717G>C	c.(715-717)AAG>AAC	p.K239N	DBF4B_uc010wjb.1_Intron|DBF4B_uc002ihe.2_Missense_Mutation_p.K53N|DBF4B_uc010wjc.1_Missense_Mutation_p.K223N	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	239					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				GTTGCAGGAAGTTTCGTCCTT	0.493			NA											9	94					0	0	0.010729	0	0
C17orf46	124783	broad.mit.edu	37	17	43333147	43333147	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:43333147C>G	uc002iis.1	-	4	498	c.402G>C	c.(400-402)CGG>CGC	p.R134R	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Silent_p.R113R	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	134										large_intestine(1)|ovary(1)	2						CCGTGAAACTCCGGCAGTTTG	0.567			NA											6	107					0	0	0.001168	0	0
MBTD1	54799	broad.mit.edu	37	17	49280153	49280153	+	Silent	SNP	A	A	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:49280153A>G	uc002itr.3	-	10	1316	c.972T>C	c.(970-972)GAT>GAC	p.D324D	MBTD1_uc002itp.3_Silent_p.D160D|MBTD1_uc002itq.3_Silent_p.D324D	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	324	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CATCTGTTCTATCTTCGCTTT	0.423			NA											9	117					0	0	0.006214	0	0
C17orf47	284083	broad.mit.edu	37	17	56621265	56621265	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:56621265C>G	uc002iwq.1	-	1	419	c.283G>C	c.(283-285)GAA>CAA	p.E95Q		NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	95										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGGATGATTCTGTTCTTGGT	0.537			NA											5	55					0	0	0.000602	0	0
HELZ	9931	broad.mit.edu	37	17	65103325	65103325	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:65103325G>C	uc010wqk.1	-	31	5391	c.5204C>G	c.(5203-5205)TCT>TGT	p.S1735C	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.S1734C	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TACTGTTCGAGATGACAATGG	0.398			NA											7	147					0	0	0.001984	0	0
SDK2	54549	broad.mit.edu	37	17	71427671	71427671	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:71427671C>T	uc010dfm.2	-	11	1450	c.1450G>A	c.(1450-1452)GAT>AAT	p.D484N	SDK2_uc010dfn.2_Missense_Mutation_p.D163N	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	484	Ig-like C2-type 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						GAGGCCTCATCGACCCCCCGA	0.597			NA											19	172					0	0	0.010504	0	0
KIF19	124602	broad.mit.edu	37	17	72350304	72350304	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:72350304G>A	uc002jkm.3	+	18	2450	c.2312G>A	c.(2311-2313)AGG>AAG	p.R771K		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	771					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GCTGCAGAGAGGAAGGAGATC	0.607			NA											5	84					0	0	0.000602	0	0
BAHCC1	57597	broad.mit.edu	37	17	79410070	79410070	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:79410070G>C	uc002kaf.2	+	3	1695	c.1695G>C	c.(1693-1695)AAG>AAC	p.K565N	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	565							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CTGAGGCCAAGCGCAAGTCCC	0.716			NA											4	42					0	0	0.009096	0	0
SIRT7	51547	broad.mit.edu	37	17	79875977	79875977	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr17:79875977G>A	uc002kcj.1	-	1	64	c.31C>T	c.(31-33)CGC>TGC	p.R11C	SIRT7_uc002kck.1_5'UTR|SIRT7_uc002kcl.1_5'UTR	NM_016538	NP_057622	Q9NRC8	SIRT7_HUMAN	sirtuin 7	11	Arg-rich.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GCCGCTTTGCGCTCGGAGCGG	0.597			NA											5	39					0	0	0.001984	0	0
ZNF521	25925	broad.mit.edu	37	18	22804498	22804498	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr18:22804498C>T	uc002kvk.2	-	4	3631	c.3384G>A	c.(3382-3384)GAG>GAA	p.E1128E	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.E1128E|ZNF521_uc002kvl.2_Silent_p.E908E	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1128					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGCCTTTCCCCTCAATGGCAC	0.542			NA	T	PAX5	ALL								9	51					0	0	0.004482	0	0
CCBE1	147372	broad.mit.edu	37	18	57103325	57103325	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr18:57103325G>T	uc002lib.2	-	11	1106	c.1036C>A	c.(1036-1038)CGC>AGC	p.R346S	CCBE1_uc010dpq.2_Missense_Mutation_p.R75S|CCBE1_uc002lia.2_Missense_Mutation_p.R199S	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	346					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				ATGTCATTGCGGATGTCAGCC	0.522	NSCLC(137;1340 1860 15773 39604 51087)|Esophageal Squamous(139;339 1777 2926 19691 38524)		NA											13	118					3.27435e-08	4.21763e-08	0.00245	1	0
STK11	6794	broad.mit.edu	37	19	1218415	1218415	+	Splice_Site	SNP	G	G	T	rs112675807		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:1218415G>T	uc002lrl.1	+	2	1406	c.291_splice	c.e2-1	p.K97_splice		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11						anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(3)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTGTCCCAGGGAAATTCAA	0.522			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			23	106					3.62473e-10	4.79599e-10	0.012319	1	0
DAPK3	1613	broad.mit.edu	37	19	3964802	3964802	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:3964802C>T	uc002lzc.1	-	2	343	c.250G>A	c.(250-252)GAG>AAG	p.E84K	DAPK3_uc002lzb.1_5'Flank|DAPK3_uc002lzd.1_Missense_Mutation_p.E84K	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	84	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCTTGTTCTCGAAGATGTCG	0.632			NA											14	86					0	0	0.001855	0	0
LASS4	79603	broad.mit.edu	37	19	8326635	8326635	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:8326635C>G	uc002mjg.2	+	11	1232	c.912C>G	c.(910-912)TTC>TTG	p.F304L	LASS4_uc002mjh.2_Missense_Mutation_p.F253L|LASS4_uc002mji.2_Missense_Mutation_p.F140L|LASS4_uc010dvz.2_Intron	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	304	TLC.|Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						GCTACTACTTCTTCAACGGGC	0.552			NA											8	65					0	0	0.00308	0	0
PRAM1	84106	broad.mit.edu	37	19	8563881	8563881	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:8563881T>C	uc002mkd.2	-	2	831	c.811A>G	c.(811-813)AAA>GAA	p.K271E	PRAM1_uc002mkc.2_Missense_Mutation_p.K271E	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	319	Pro-rich.						lipid binding|protein binding				0						GAGGCCTTTTTGGGAAAGGCG	0.632			NA											14	40					0	0	0.00245	0	0
MUC16	94025	broad.mit.edu	37	19	9061796	9061796	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:9061796C>T	uc002mkp.2	-	3	25854	c.25650G>A	c.(25648-25650)CCG>CCA	p.P8550P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8552	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGGAAGGCTCGGCCATGGCA	0.498			NA											5	42					0	0	0.000602	0	0
OR7G2	390882	broad.mit.edu	37	19	9213383	9213383	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:9213383A>T	uc010xkk.1	-	1	600	c.600T>A	c.(598-600)TGT>TGA	p.C200*		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAGCCAGTTCACAGAAGAAGA	0.473	Esophageal Squamous(67;143 1448 28637 40648)		NA											6	48					0	0	0.001168	0	0
OR7G1	125962	broad.mit.edu	37	19	9226385	9226385	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:9226385C>T	uc002mks.1	-	1	55	c.55G>A	c.(55-57)GAG>AAG	p.E19K		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TCTGGGTCCTCTGTCACTTTC	0.433			NA											8	90					0	0	0.006214	0	0
CARM1	10498	broad.mit.edu	37	19	11031219	11031219	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:11031219C>T	uc002mpz.2	+	11	1430	c.1304C>T	c.(1303-1305)TCA>TTA	p.S435L	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Missense_Mutation_p.S218L	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	435					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						GACACGCTCTCAGGGACATGT	0.637			NA											4	44					0	0	0.009096	0	0
CARM1	10498	broad.mit.edu	37	19	11032406	11032406	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:11032406G>A	uc002mpz.2	+	16	1926	c.1800G>A	c.(1798-1800)CCG>CCA	p.P600P	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Silent_p.P360P	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	600	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						TGTCCATCCCGACCAACACCA	0.557			NA											8	84					0	0	0.006214	0	0
C19orf43	79002	broad.mit.edu	37	19	12842184	12842184	+	Missense_Mutation	SNP	C	C	A	rs11542951		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:12842184C>A	uc002muu.2	-	2	455	c.397G>T	c.(397-399)GCC>TCC	p.A133S		NM_024038	NP_076943	Q9BQ61	CS043_HUMAN	hypothetical protein MGC2803	133											0						TGCTTCTTGGCTACTATTCCC	0.597			NA											11	58					3.07112e-06	3.78058e-06	0.010729	1	0
CYP4F3	4051	broad.mit.edu	37	19	15760837	15760837	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:15760837G>A	uc002nbj.2	+	7	812	c.762G>A	c.(760-762)CAG>CAA	p.Q254Q	CYP4F3_uc010xok.1_Silent_p.Q254Q|CYP4F3_uc010xol.1_Silent_p.Q254Q|CYP4F3_uc010xom.1_Silent_p.Q105Q|CYP4F3_uc002nbk.2_Silent_p.Q254Q|CYP4F3_uc010xon.1_5'UTR	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	254					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						CTGATGGGCAGCGTTTCCGCA	0.577			NA											37	103					0	0	0.005524	0	0
SPTBN4	57731	broad.mit.edu	37	19	41063206	41063206	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:41063206G>A	uc002ony.2	+	26	5653	c.5567G>A	c.(5566-5568)CGG>CAG	p.R1856Q	SPTBN4_uc002onx.2_Missense_Mutation_p.R1856Q|SPTBN4_uc002onz.2_Missense_Mutation_p.R1856Q|SPTBN4_uc010egx.2_Missense_Mutation_p.R599Q|SPTBN4_uc002ooa.2_Missense_Mutation_p.R532Q	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1856	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AAGCGGAGGCGGCTGCCCCGC	0.647			NA											6	59					0	0	0.001168	0	0
CYP2A7	1549	broad.mit.edu	37	19	41383245	41383245	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:41383245C>G	uc002opm.2	-	7	1553	c.1011G>C	c.(1009-1011)AAG>AAC	p.K337N	CYP2A7_uc002opo.2_Missense_Mutation_p.K337N|CYP2A7_uc002opn.2_Missense_Mutation_p.K286N	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	337						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GCTGCCGGTTCTTGCCGATCA	0.532			NA											6	59					0	0	0.004482	0	0
ZNF526	116115	broad.mit.edu	37	19	42729969	42729969	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:42729969C>T	uc002osz.1	+	3	1570	c.1414C>T	c.(1414-1416)CAC>TAC	p.H472Y		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	472	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				TGAACGGCGTCACCGCTGTGG	0.652			NA											12	107					0	0	0.00245	0	0
MEGF8	1954	broad.mit.edu	37	19	42853690	42853690	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:42853690A>C	uc002otl.3	+	13	2772	c.2137A>C	c.(2137-2139)ACG>CCG	p.T713P	MEGF8_uc002otm.3_Missense_Mutation_p.T321P	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	780	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GGAGAAGGAGACGCGGCGGCT	0.647			NA											5	27					0	0	0.001168	0	0
ZNF841	284371	broad.mit.edu	37	19	52568907	52568907	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:52568907C>A	uc002pyl.1	-	5	2432	c.1880G>T	c.(1879-1881)GGG>GTG	p.G627V	ZNF841_uc010ydh.1_Missense_Mutation_p.G743V|ZNF841_uc010epk.1_Intron	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	627	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGACTTTCCCACATTCAAT	0.393			NA											7	12					8.12818e-05	9.4384e-05	0.001984	1	0
C19orf51	352909	broad.mit.edu	37	19	55670627	55670627	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:55670627C>G	uc002qji.1	-	12	1463	c.1429G>C	c.(1429-1431)GAC>CAC	p.D477H	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.D292H|C19orf51_uc002qjj.1_Missense_Mutation_p.D524H|C19orf51_uc002qjk.1_Missense_Mutation_p.D423H|C19orf51_uc002qjl.1_Missense_Mutation_p.D544H			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	477											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GCCAGGATGTCAAGGGGCGGA	0.647			NA											5	31					0	0	0.001168	0	0
U2AF2	11338	broad.mit.edu	37	19	56180086	56180086	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:56180086C>G	uc002qlu.2	+	9	1928	c.873C>G	c.(871-873)GTC>GTG	p.V291V	U2AF2_uc002qlt.2_Silent_p.V291V	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	291	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TCAACCTGGTCAAGGACAGTG	0.632			NA											9	65					0	0	0.008291	0	0
MBOAT2	129642	broad.mit.edu	37	2	9008594	9008594	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:9008594C>G	uc002qzg.1	-	9	1102	c.969G>C	c.(967-969)TTG>TTC	p.L323F	MBOAT2_uc010yix.1_Missense_Mutation_p.L323F	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain	323					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTTGAATTCTCAAATTGGAAA	0.363	Ovarian(194;1699 3813 22401)		NA											8	58					0	0	0.00308	0	0
TP53I3	9540	broad.mit.edu	37	2	24305854	24305854	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:24305854C>T	uc002rey.1	-	3	367	c.307G>A	c.(307-309)GAA>AAA	p.E103K	LOC375190_uc002rew.2_Intron|TP53I3_uc002rex.1_Missense_Mutation_p.E103K|TP53I3_uc002rez.1_Missense_Mutation_p.E103K|TP53I3_uc010ykk.1_Intron	NM_147184	NP_671713	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	103					induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGCCCTTCGGGGACAGTG	0.652			NA											4	41					0	0	0.009096	0	0
ASXL2	55252	broad.mit.edu	37	2	25966745	25966745	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:25966745G>A	uc002rgs.2	-	12	2682	c.2461C>T	c.(2461-2463)CCA>TCA	p.P821S	ASXL2_uc002rgt.1_Missense_Mutation_p.P561S	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	821					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCCTTGTGGATGGCTGACA	0.522			NA											16	199					0	0	0.004007	0	0
CAPN13	92291	broad.mit.edu	37	2	30966341	30966341	+	Silent	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:30966341C>A	uc002rnn.2	-	12	1529	c.1353G>T	c.(1351-1353)CTG>CTT	p.L451L	CAPN13_uc002rnm.2_RNA|CAPN13_uc002rno.2_Silent_p.L5L	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	451					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TCCCAGGGCTCAGATGGTAAG	0.463			NA											27	168					7.92952e-12	1.07853e-11	0.003954	1	0
THUMPD2	80745	broad.mit.edu	37	2	39963894	39963894	+	Missense_Mutation	SNP	G	G	A	rs145653260	byFrequency	TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:39963894G>A	uc002rru.2	-	10	1530	c.1493C>T	c.(1492-1494)TCG>TTG	p.S498L	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Missense_Mutation_p.S389L	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	498							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				AGAAGAGTGCGACTTCTTATA	0.448			NA											4	36					0	0	0.009096	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655756	40655756	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:40655756G>T	uc002rrx.2	-	1	1689	c.1665C>A	c.(1663-1665)ATC>ATA	p.I555I	SLC8A1_uc002rry.2_Silent_p.I555I|SLC8A1_uc002rrz.2_Silent_p.I555I|SLC8A1_uc002rsa.2_Silent_p.I555I|SLC8A1_uc002rsd.3_Silent_p.I555I|SLC8A1_uc002rsb.1_Silent_p.I555I|SLC8A1_uc010fan.1_Silent_p.I555I|SLC8A1_uc002rsc.1_Silent_p.I555I	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	555	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCACCTCCATGATGCCAATGC	0.458			NA											9	97					2.17888e-05	2.592e-05	0.006214	1	0
ASB3	51130	broad.mit.edu	37	2	53977961	53977961	+	Missense_Mutation	SNP	G	G	C	rs139014010		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:53977961G>C	uc002rxg.1	-	3	449	c.314C>G	c.(313-315)CCT>CGT	p.P105R	ASB3_uc002rxh.1_Missense_Mutation_p.P32R|ASB3_uc002rxi.3_Missense_Mutation_p.P143R|ASB3_uc010yoo.1_Missense_Mutation_p.P105R	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	105	ANK 3.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGTTGCATTAGGATCTGCCCC	0.353			NA											9	45					0	0	0.006214	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472433	69472433	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:69472433C>G	uc002sfg.2	+	18	1867	c.1511C>G	c.(1510-1512)TCC>TGC	p.S504C		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	504	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						TACCACAcctcctcgccgcct	0.249			NA							Familial_Infantile_Hemangioma				3	53					0	0	0.009096	0	0
MARCO	8685	broad.mit.edu	37	2	119727727	119727727	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:119727727G>T	uc002tln.1	+	3	369	c.237G>T	c.(235-237)ATG>ATT	p.M79I	MARCO_uc010yyf.1_Missense_Mutation_p.M1I	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	79	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TCCTGGAGATGTATTTCCTCA	0.577	GBM(8;18 374 7467 11269 32796)		NA											13	78					6.31663e-08	8.05629e-08	0.003163	1	0
POTEF	728378	broad.mit.edu	37	2	130877990	130877990	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:130877990G>A	uc010fmh.2	-	3	499	c.99C>T	c.(97-99)CCC>CCT	p.P33P		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	33						cell cortex	ATP binding			skin(3)|ovary(2)	5						CCCTGCAGCAGGGGAAGCAAC	0.577			NA											26	246					0	0	0.00632	0	0
GPR148	344561	broad.mit.edu	37	2	131487352	131487352	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:131487352C>A	uc002trv.1	+	1	630	c.628C>A	c.(628-630)CAG>AAG	p.Q210K		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	210	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					CATGGGCACCCAGCCGGGATG	0.542			NA											14	90					3.27435e-08	4.21763e-08	0.00245	1	0
LCT	3938	broad.mit.edu	37	2	136547323	136547323	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:136547323G>A	uc002tuu.1	-	16	5392	c.5381C>T	c.(5380-5382)GCG>GTG	p.A1794V		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1794	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATTGTCCATCGCACTCCAAAC	0.483			NA											13	128					0	0	0.001368	0	0
LRP1B	53353	broad.mit.edu	37	2	141680547	141680548	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:141680547_141680548GG>TT	uc002tvj.1	-	21	4277_4278	c.3305_3306CC>AA	c.(3304-3306)TCC>TAA	p.S1102*	LRP1B_uc010fnl.1_Nonsense_Mutation_p.S284*	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1102	Extracellular (Potential).|LDL-receptor class A 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TACTCCAACAGGAAAACTTGGT	0.441	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			7	41					0	0	0.004672	0	0
FIGN	55137	broad.mit.edu	37	2	164468312	164468312	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:164468312C>G	uc002uck.1	-	3	341	c.30G>C	c.(28-30)TTG>TTC	p.L10F		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	10						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						ACTGCATCTTCAAGCCTAAGA	0.443			NA											3	42					0	0	0.004672	0	0
SCN3A	6328	broad.mit.edu	37	2	165947170	165947170	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:165947170T>A	uc002ucx.2	-	28	5985	c.5493A>T	c.(5491-5493)AAA>AAT	p.K1831N	SCN3A_uc010zcy.1_Missense_Mutation_p.K314N|SCN3A_uc002ucy.2_Missense_Mutation_p.K1782N|SCN3A_uc002ucz.2_Missense_Mutation_p.K1782N	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1831						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TAAGCTGGACTTTGTTGGGTT	0.453			NA											9	99					0	0	0.008291	0	0
LRP2	4036	broad.mit.edu	37	2	170042448	170042448	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:170042448C>G	uc002ues.2	-	50	9623	c.9410G>C	c.(9409-9411)TGT>TCT	p.C3137S		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3137	EGF-like 11.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCAGGACGACAGGAACAATA	0.438			NA											7	66					0	0	0.001984	0	0
ATF2	1386	broad.mit.edu	37	2	175957959	175957959	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:175957959T>C	uc002ujl.2	-	12	1277	c.1015A>G	c.(1015-1017)ACA>GCA	p.T339A	ATF2_uc010fqv.2_Missense_Mutation_p.T290A|ATF2_uc002ujv.2_Missense_Mutation_p.T86A|ATF2_uc002ujm.2_Missense_Mutation_p.T281A|ATF2_uc002ujn.2_RNA|ATF2_uc002ujo.2_Intron|ATF2_uc002ujp.2_RNA|ATF2_uc002ujq.2_Missense_Mutation_p.T339A|ATF2_uc002ujr.2_RNA|ATF2_uc010fqu.2_Missense_Mutation_p.T321A|ATF2_uc002ujs.2_Missense_Mutation_p.T281A|ATF2_uc002ujt.2_RNA|ATF2_uc002uju.2_RNA|ATF2_uc002ujw.1_Missense_Mutation_p.T281A|ATF2_uc002ujx.1_RNA	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	339					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(1)|breast(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.125)			CGACCACTTGTACTTTGGGTC	0.413	Pancreas(17;87 705 4534 15538 30988)		NA											4	32					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179591958	179591958	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:179591958C>T	uc010zfg.1	-	66	16626	c.16402G>A	c.(16402-16404)GAT>AAT	p.D5468N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D2129N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6395							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTACTTATCACTGGCTGGA	0.443			NA											7	52					0	0	0.00308	0	0
DNAH7	56171	broad.mit.edu	37	2	196740445	196740445	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:196740445C>A	uc002utj.3	-	38	6341	c.6240G>T	c.(6238-6240)ATG>ATT	p.M2080I		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2080	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTAGTTTAATCATGGAACAAT	0.418			NA											9	32					3.09899e-07	3.90131e-07	0.004482	1	0
PLCL1	5334	broad.mit.edu	37	2	198950567	198950567	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:198950567C>G	uc010fsp.2	+	2	2617	c.2326C>G	c.(2326-2328)CCT>GCT	p.P776A	PLCL1_uc002uuv.3_Missense_Mutation_p.P697A	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	776	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CAGTGATAATCCTATTTTTGA	0.393			NA											6	61					0	0	0.001168	0	0
TTLL4	9654	broad.mit.edu	37	2	219602948	219602948	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:219602948C>G	uc002viy.2	+	3	919	c.549C>G	c.(547-549)CTC>CTG	p.L183L	TTLL4_uc010zkl.1_Silent_p.L18L|TTLL4_uc010fvx.2_Silent_p.L183L	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	183					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AACCATACCTCTGCTTGGCAG	0.567	GBM(172;1818 2053 15407 20943 49753)		NA											6	113					0	0	0.001168	0	0
NGEF	25791	broad.mit.edu	37	2	233745891	233745891	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:233745891G>T	uc002vts.2	-	14	2155	c.1907C>A	c.(1906-1908)GCC>GAC	p.A636D	NGEF_uc010zmm.1_Missense_Mutation_p.A359D|NGEF_uc010fyg.1_Missense_Mutation_p.A544D	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	636	SH3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GAGGATGTCGGCGAGCTCCAG	0.662			NA											13	73					2.61681e-11	3.52229e-11	0.00245	1	0
UGT1A5	54579	broad.mit.edu	37	2	234622209	234622209	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr2:234622209C>G	uc002vuw.2	+	1	572	c.572C>G	c.(571-573)TCC>TGC	p.S191C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Missense_Mutation_p.S191C	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	191					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		CCAAACCCTTCCTCCTATATT	0.478			NA											14	201					0	0	0.001855	0	0
CSNK2A1	1457	broad.mit.edu	37	20	485802	485802	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:485802T>C	uc002wdw.1	-	4	566	c.173A>G	c.(172-174)AAC>AGC	p.N58S	CSNK2A1_uc002wdx.1_Missense_Mutation_p.N58S|CSNK2A1_uc002wdy.1_5'UTR	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	58	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			ATTTGTGATGTTGATGGCTTC	0.313			NA											5	28					0	0	0.001168	0	0
PTPRA	5786	broad.mit.edu	37	20	3005234	3005234	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:3005234G>A	uc010zqd.1	+	16	1931	c.1614G>A	c.(1612-1614)GGG>GGA	p.G538G	PTPRA_uc002whj.2_Silent_p.G527G|PTPRA_uc002whk.2_Silent_p.G518G|PTPRA_uc002whl.2_Silent_p.G518G|PTPRA_uc002whm.2_Silent_p.G294G|PTPRA_uc002whn.2_Silent_p.G518G|PTPRA_uc002who.2_Silent_p.G190G	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	527	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						AAATCCCAGGGACCAGCAACA	0.453			NA											7	121					0	0	0.001984	0	0
HSPA12B	116835	broad.mit.edu	37	20	3725682	3725682	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:3725682G>C	uc002wjd.2	+	5	503	c.400G>C	c.(400-402)GCG>CCG	p.A134P	HSPA12B_uc010zqi.1_Missense_Mutation_p.A134P|HSPA12B_uc002wje.2_Missense_Mutation_p.A47P|HSPA12B_uc010zqj.1_5'UTR	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	134							ATP binding				0						CCCCGAAGAGGCGCGGGACTG	0.622			NA											21	203					0	0	0.012319	0	0
PAK7	57144	broad.mit.edu	37	20	9561232	9561232	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:9561232C>T	uc002wnl.2	-	5	1095	c.550G>A	c.(550-552)GAG>AAG	p.E184K	PAK7_uc002wnk.2_Missense_Mutation_p.E184K|PAK7_uc002wnj.2_Missense_Mutation_p.E184K|PAK7_uc010gby.1_Missense_Mutation_p.E184K	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	184	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GGCTTCACCTCAGAATAGTAG	0.458			NA											12	117					0	0	0.001368	0	0
CD93	22918	broad.mit.edu	37	20	23066051	23066051	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:23066051G>A	uc002wsv.2	-	1	927	c.779C>T	c.(778-780)CCC>CTC	p.P260L		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	260	EGF-like 1.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCCATACTTGGGGCTGACACA	0.602			NA											14	172					0	0	0.00245	0	0
EIF6	3692	broad.mit.edu	37	20	33867900	33867900	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:33867900C>G	uc002xbv.1	-	4	607	c.391G>C	c.(391-393)GAT>CAT	p.D131H	EDEM2_uc010zuv.1_5'Flank|EIF6_uc002xbx.1_Missense_Mutation_p.D131H|EIF6_uc002xbz.1_Missense_Mutation_p.D112H|EIF6_uc002xby.1_RNA	NM_181468	NP_852133	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	131					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TTGAGCACATCTGCCAGAATT	0.507			NA											6	172					0	0	0.00308	0	0
EIF6	3692	broad.mit.edu	37	20	33867912	33867912	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:33867912C>T	uc002xbv.1	-	4	595	c.379G>A	c.(379-381)GAA>AAA	p.E127K	EDEM2_uc010zuv.1_5'Flank|EIF6_uc002xbx.1_Missense_Mutation_p.E127K|EIF6_uc002xbz.1_Missense_Mutation_p.E108K|EIF6_uc002xby.1_RNA	NM_181468	NP_852133	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	127					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCCAGAATTTCTTCTGTCTCC	0.517			NA											6	156					0	0	0.001168	0	0
CPNE1	8904	broad.mit.edu	37	20	34214539	34214539	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:34214539C>G	uc002xdf.2	-	17	1786	c.1423G>C	c.(1423-1425)GCT>CCT	p.A475P	CPNE1_uc002xdc.2_Missense_Mutation_p.A137P|CPNE1_uc010zvj.1_Missense_Mutation_p.A480P|CPNE1_uc002xde.2_Missense_Mutation_p.A451P|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.A475P|CPNE1_uc002xdi.2_Missense_Mutation_p.A475P|CPNE1_uc002xdj.2_Missense_Mutation_p.A475P|CPNE1_uc002xdk.2_Missense_Mutation_p.A475P|CPNE1_uc002xdl.2_Missense_Mutation_p.A475P|CPNE1_uc002xdm.2_Missense_Mutation_p.A475P	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	475	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CGGGCAGCAGCCTGCCCAGAA	0.557			NA											4	137					0	0	0.009096	0	0
CHD6	84181	broad.mit.edu	37	20	40054752	40054752	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:40054752C>A	uc002xka.1	-	28	4288	c.4110G>T	c.(4108-4110)AAG>AAT	p.K1370N		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1370					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGTCATCCTTCTTTTCGCTAA	0.423			NA											7	179					5.18039e-06	6.31715e-06	0.00308	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47582495	47582495	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:47582495G>C	uc002xtx.3	+	8	1146	c.994G>C	c.(994-996)GAT>CAT	p.D332H		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	332					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CCCAGGAGTTGATGAAAACTC	0.483	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											5	29					0	0	0.000602	0	0
DIDO1	11083	broad.mit.edu	37	20	61512816	61512816	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:61512816C>G	uc002ydr.1	-	16	4756	c.4492G>C	c.(4492-4494)GAA>CAA	p.E1498Q	DIDO1_uc002yds.1_Missense_Mutation_p.E1498Q	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1498					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTGAGAGCTTCTTCTTGCTCC	0.607	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											4	124					0	0	0.000602	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31691969	31691969	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr21:31691969G>T	uc002ynw.2	-	1	639	c.385C>A	c.(385-387)CTC>ATC	p.L129I		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	129						intermediate filament				ovary(1)	1						TAACTATTGAGCAGCGGCCTC	0.537			NA											29	156					1.39806e-14	1.93539e-14	0.008361	1	0
SOD1	6647	broad.mit.edu	37	21	33036154	33036154	+	Missense_Mutation	SNP	G	G	T	rs121912433		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr21:33036154G>T	uc002ypa.2	+	2	272	c.124G>T	c.(124-126)GGC>TGC	p.G42C	SOD1_uc002ypb.2_Missense_Mutation_p.G23C|SOD1_uc002ypc.2_RNA	NM_000454	NP_000445	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	42			G -> D (in ALS1).|G -> S (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding				0						ACTGACTGAAGGCCTGCATGG	0.433			NA											15	80					2.48551e-13	3.40444e-13	0.00499	1	0
PFKL	5211	broad.mit.edu	37	21	45741720	45741720	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr21:45741720G>T	uc002zel.2	+	13	1359	c.1300G>T	c.(1300-1302)GTG>TTG	p.V434L	PFKL_uc002zek.2_Missense_Mutation_p.V481L|PFKL_uc002zem.2_Missense_Mutation_p.V21L|PFKL_uc002zen.2_Missense_Mutation_p.V21L	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	434					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		CACAGTATACGTGGTGCACGA	0.647			NA											19	85					5.03518e-11	6.75409e-11	0.007413	1	0
TCF20	6942	broad.mit.edu	37	22	42605678	42605678	+	Silent	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr22:42605678C>A	uc003bcj.1	-	1	5768	c.5634G>T	c.(5632-5634)GCG>GCT	p.A1878A	TCF20_uc003bck.1_Silent_p.A1878A|TCF20_uc003bnt.2_Silent_p.A1878A	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1878					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CTATTTCCAGCGCTTCCTGCA	0.433			NA											5	116					3.59834e-05	4.24167e-05	0.001168	1	0
EFCAB6	64800	broad.mit.edu	37	22	44178131	44178131	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr22:44178131G>C	uc003bdy.1	-	3	283	c.68C>G	c.(67-69)TCA>TGA	p.S23*	EFCAB6_uc003bdz.1_Intron|EFCAB6_uc010gzi.1_5'UTR|EFCAB6_uc011aqa.1_5'UTR|EFCAB6_uc003bea.1_Nonsense_Mutation_p.S20*|EFCAB6_uc003beb.3_5'UTR	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				ATGGGGTCTTGAATGTGTAAA	0.373			NA											4	57					0	0	0.009096	0	0
FGD5	152273	broad.mit.edu	37	3	14862303	14862303	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:14862303G>A	uc003bzc.2	+	1	1835	c.1725G>A	c.(1723-1725)AGG>AGA	p.R575R	FGD5_uc011avk.1_Silent_p.R575R	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	575					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						ATGACCACAGGATAAAGAGGA	0.557			NA											4	36					0	0	0.009096	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54905639	54905639	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:54905639G>A	uc003dhf.2	+	18	1748	c.1700G>A	c.(1699-1701)CGA>CAA	p.R567Q	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.R473Q|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.R301Q	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	567	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGGGAAGACCGAGATGACGTG	0.493			NA											4	47					0	0	0.001168	0	0
FAM19A1	407738	broad.mit.edu	37	3	68587954	68587954	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:68587954G>C	uc003dnd.2	+	4	523	c.307G>C	c.(307-309)GAA>CAA	p.E103Q	FAM19A1_uc003dne.2_Missense_Mutation_p.E103Q|FAM19A1_uc003dng.2_Missense_Mutation_p.E103Q	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	103						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		GCCTTGCCTAGAAGGAGAAGA	0.438			NA											7	48					0	0	0.00308	0	0
EPHA3	2042	broad.mit.edu	37	3	89259011	89259011	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:89259011G>A	uc003dqy.2	+	3	380	c.155G>A	c.(154-156)TGG>TAG	p.W52*	EPHA3_uc003dqx.1_Nonsense_Mutation_p.W52*|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	52	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATTCTTCAGTGGGAAGAGATC	0.398			NA								TSP Lung(6;0.00050)			6	18					0	0	0.001168	0	0
EPHA3	2042	broad.mit.edu	37	3	89521758	89521758	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:89521758G>C	uc003dqy.2	+	16	3060	c.2835G>C	c.(2833-2835)AAG>AAC	p.K945N	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	945	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CAATAGCCAAGATTTCCACAG	0.408			NA								TSP Lung(6;0.00050)			6	66					0	0	0.001168	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632712	122632712	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:122632712C>T	uc003efz.1	-	15	2429	c.2125G>A	c.(2125-2127)GAG>AAG	p.E709K	SEMA5B_uc011bju.1_Missense_Mutation_p.E651K|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.E709K|SEMA5B_uc010hro.1_Missense_Mutation_p.E651K|SEMA5B_uc003efy.1_5'Flank	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	709	Extracellular (Potential).|TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CACCGTTCCTCCCGGCTCTTG	0.662			NA											8	95					0	0	0.008291	0	0
CCDC37	348807	broad.mit.edu	37	3	126138534	126138534	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:126138534C>G	uc003eiu.1	+	9	885	c.786C>G	c.(784-786)TTC>TTG	p.F262L	CCDC37_uc010hsg.1_Missense_Mutation_p.F263L	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	262										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		ATAAGGATTTCCTATACAAGC	0.502			NA											4	84					0	0	0.000602	0	0
MGLL	11343	broad.mit.edu	37	3	127439934	127439934	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:127439934G>A	uc003ejx.2	-	5	587	c.442C>T	c.(442-444)CTG>TTG	p.L148L	MGLL_uc003ejw.2_Silent_p.L158L|MGLL_uc011bko.1_Silent_p.L158L|MGLL_uc010hsp.1_Silent_p.L148L|MGLL_uc003ejv.2_Silent_p.L122L	NM_001003794	NP_001003794	Q99685	MGLL_HUMAN	monoglyceride lipase isoform 2	148					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity				0						GCAAGAACCAGAGGCGAAATG	0.552			NA											6	48					0	0	0.001984	0	0
RUVBL1	8607	broad.mit.edu	37	3	127817729	127817729	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:127817729G>C	uc003ekh.2	-	7	917	c.813C>G	c.(811-813)ATC>ATG	p.I271M	RUVBL1_uc003eke.2_Missense_Mutation_p.I12M|RUVBL1_uc003ekf.2_Missense_Mutation_p.I211M|RUVBL1_uc010hss.2_Missense_Mutation_p.I271M	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	271					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		TCCTACCTGTGATTTCTGTCT	0.547			NA											3	65					0	0	0.004672	0	0
IFT122	55764	broad.mit.edu	37	3	129211017	129211017	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:129211017G>C	uc003emm.2	+	17	2232	c.2026G>C	c.(2026-2028)GAG>CAG	p.E676Q	IFT122_uc003eml.2_Missense_Mutation_p.E727Q|IFT122_uc003emn.2_Missense_Mutation_p.E617Q|IFT122_uc003emo.2_Missense_Mutation_p.E565Q|IFT122_uc003emp.2_Missense_Mutation_p.E526Q|IFT122_uc010htc.2_Missense_Mutation_p.E668Q|IFT122_uc011bky.1_Missense_Mutation_p.E467Q|IFT122_uc003emq.2_Missense_Mutation_p.E516Q|IFT122_uc003emr.2_Intron|IFT122_uc011bla.1_Intron|IFT122_uc010hte.2_Missense_Mutation_p.E56Q|IFT122_uc003ems.2_Intron|IFT122_uc011bkx.1_Missense_Mutation_p.E516Q|IFT122_uc010htd.1_Missense_Mutation_p.E155Q	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	676					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CCGATATTTAGAGCTCATCAG	0.438			NA											9	135					0	0	0.006214	0	0
CPNE4	131034	broad.mit.edu	37	3	131388587	131388587	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:131388587G>A	uc003eok.2	-	7	1048	c.613C>T	c.(613-615)CCA>TCA	p.P205S	CPNE4_uc011blq.1_Missense_Mutation_p.P223S|CPNE4_uc003eol.2_Missense_Mutation_p.P223S|CPNE4_uc003eom.2_Missense_Mutation_p.P205S	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	205	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTCCAGGCTGGGCTTAAGTTA	0.428			NA											6	80					0	0	0.001168	0	0
MRPS22	56945	broad.mit.edu	37	3	139065737	139065737	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:139065737G>C	uc003etb.2	+	2	198	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.E63Q|MRPS22_uc003ete.2_Missense_Mutation_p.E23Q	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	64						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						TGGTAGCCCAGAGACCAAGAA	0.363			NA											4	44					0	0	0.009096	0	0
SI	6476	broad.mit.edu	37	3	164757724	164757724	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:164757724G>C	uc003fei.2	-	19	2257	c.2195C>G	c.(2194-2196)ACT>AGT	p.T732S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	732	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAAAAACTCAGTGTCCTCAAT	0.333			NA								HNSCC(35;0.089)			7	102					0	0	0.001984	0	0
SI	6476	broad.mit.edu	37	3	164786563	164786563	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:164786563T>G	uc003fei.2	-	5	492	c.430A>C	c.(430-432)AAC>CAC	p.N144H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	144	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGAACACTGTTGATGTCATTT	0.343			NA								HNSCC(35;0.089)			3	63					0	0	0.009096	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916873	178916873	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:178916873G>C	uc003fjk.2	+	2	417	c.260G>C	c.(259-261)AGA>ACA	p.R87T		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	87	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GATGAAACAAGACGACTTTGT	0.363	Colon(199;1504 1750 3362 26421 31210 32040)		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			4	63					0	0	0.009096	0	0
ATP13A5	344905	broad.mit.edu	37	3	193068888	193068888	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:193068888A>T	uc011bsq.1	-	7	709	c.709T>A	c.(709-711)TCC>ACC	p.S237T		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	237	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AAGACAATGGAGATAACAGTC	0.388			NA											5	22					0	0	0.000602	0	0
MUC4	4585	broad.mit.edu	37	3	195516290	195516290	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:195516290C>G	uc011bto.1	-	2	2621	c.2161G>C	c.(2161-2163)GAT>CAT	p.D721H	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.D603H	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	726					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGGTGGCATCATGGCTGCTG	0.612			NA											7	142					0	0	0.00308	0	0
MUC4	4585	broad.mit.edu	37	3	195516684	195516684	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:195516684C>T	uc011bto.1	-	2	2227	c.1767G>A	c.(1765-1767)ATG>ATA	p.M589I	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.M471I	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	594					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CCGTTTTTATCATCTGAGTCA	0.478			NA											24	338					0	0	0.004656	0	0
MUC4	4585	broad.mit.edu	37	3	195516687	195516687	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:195516687C>T	uc011bto.1	-	2	2224	c.1764G>A	c.(1762-1764)CAG>CAA	p.Q588Q	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Silent_p.Q470Q	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	593					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TTTTTATCATCTGAGTCACAC	0.488			NA											25	335					0	0	0.005443	0	0
MUC4	4585	broad.mit.edu	37	3	195518150	195518150	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:195518150G>C	uc011bto.1	-	2	761	c.301C>G	c.(301-303)CTT>GTT	p.L101V	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_5'Flank	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	101					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAAGAAAAAAGAGTTGATGTC	0.478			NA											7	75					0	0	0.001984	0	0
MUC4	4585	broad.mit.edu	37	3	195518254	195518254	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:195518254G>C	uc011bto.1	-	2	657	c.197C>G	c.(196-198)TCT>TGT	p.S66C	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_5'Flank	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	66					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTCCTGATTAGAGGTCCTTGA	0.483			NA											6	153					0	0	0.001168	0	0
LRRC33	375387	broad.mit.edu	37	3	196388383	196388383	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:196388383C>G	uc003fwv.2	+	3	1973	c.1869C>G	c.(1867-1869)CTC>CTG	p.L623L		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	623	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CCTGCAACCTCTCCTCCAAGA	0.647			NA											5	128					0	0	0.001168	0	0
DLG1	1739	broad.mit.edu	37	3	196831852	196831852	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:196831852C>A	uc003fxo.3	-	15	1757	c.1567G>T	c.(1567-1569)GCT>TCT	p.A523S	DLG1_uc011bub.1_Missense_Mutation_p.A407S|DLG1_uc011buc.1_Missense_Mutation_p.A407S|DLG1_uc011bud.1_Missense_Mutation_p.A206S|DLG1_uc003fxn.3_Missense_Mutation_p.A523S|DLG1_uc011bue.1_Missense_Mutation_p.A490S|DLG1_uc010ial.2_Missense_Mutation_p.A523S|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.A490S	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	523	PDZ 3.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TCATGACTAGCAGCTCTGAGG	0.388			NA											4	47					0.00909568	0.00980116	0.009096	1	0
SLC2A9	56606	broad.mit.edu	37	4	9982333	9982333	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:9982333G>T	uc003gmc.2	-	5	625	c.564C>A	c.(562-564)TAC>TAA	p.Y188*	SLC2A9_uc003gmd.2_Nonsense_Mutation_p.Y159*	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	188	Helical; Name=4; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						TCTCACTAAGGTACATGGGGA	0.567			NA											8	31					4.68919e-08	6.00031e-08	0.008291	1	0
ZNF518B	85460	broad.mit.edu	37	4	10447569	10447569	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:10447569C>G	uc003gmn.2	-	3	871	c.384G>C	c.(382-384)AGG>AGC	p.R128S		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						GCTTAAAGTTCCTTACCTTAA	0.373			NA											7	86					0	0	0.001984	0	0
BOD1L	259282	broad.mit.edu	37	4	13606644	13606644	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:13606644G>C	uc003gmz.1	-	10	1997	c.1880C>G	c.(1879-1881)CCA>CGA	p.P627R	BOD1L_uc010idr.1_5'UTR	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	627	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						AGGTTTACTTGGTTCACTTTT	0.353			NA											7	51					0	0	0.001984	0	0
SLIT2	9353	broad.mit.edu	37	4	20525659	20525659	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:20525659A>G	uc003gpr.1	+	14	1501	c.1297A>G	c.(1297-1299)ATT>GTT	p.I433V	SLIT2_uc003gps.1_Missense_Mutation_p.I433V	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	433	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GAACCCCTTTATTTGTGACTG	0.488			NA											6	146					0	0	0.00308	0	0
THAP9	79725	broad.mit.edu	37	4	83838125	83838125	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:83838125G>A	uc003hnt.2	+	5	879	c.760G>A	c.(760-762)GGT>AGT	p.G254S	THAP9_uc003hns.1_Missense_Mutation_p.G110S|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_5'UTR	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	254							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				ACCCAGTCCAGGTTTCAACAG	0.348			NA											7	74					0	0	0.001984	0	0
WDFY3	23001	broad.mit.edu	37	4	85731329	85731329	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:85731329G>A	uc003hpd.2	-	14	2464	c.2056C>T	c.(2056-2058)CAC>TAC	p.H686Y	WDFY3_uc003hpf.2_Missense_Mutation_p.H686Y	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	686						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AACACAGTGTGAAGAAGTTCA	0.448			NA											9	63					0	0	0.006214	0	0
CENPE	1062	broad.mit.edu	37	4	104084360	104084360	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:104084360C>T	uc003hxb.1	-	18	1866	c.1776G>A	c.(1774-1776)AAG>AAA	p.K592K	CENPE_uc003hxc.1_Silent_p.K567K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	592	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CCTGTAGCTTCTTAATCTGGT	0.328			NA											6	20					0	0	0.001168	0	0
ANK2	287	broad.mit.edu	37	4	114274912	114274912	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:114274912A>T	uc003ibe.3	+	38	5238	c.5138A>T	c.(5137-5139)AAA>ATA	p.K1713I	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.K1728I	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1680					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAAAAGCAGAAACAAAAAGAG	0.403			NA											8	114					0	0	0.004482	0	0
FAT4	79633	broad.mit.edu	37	4	126240995	126240995	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:126240995G>C	uc003ifj.3	+	1	3429	c.3429G>C	c.(3427-3429)CAG>CAC	p.Q1143H		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1143	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAATGGTGCAGCCAGATTTTG	0.453			NA											6	113					0	0	0.001168	0	0
ELF2	1998	broad.mit.edu	37	4	139983041	139983041	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:139983041C>T	uc003ihp.1	-	7	954	c.748G>A	c.(748-750)GAA>AAA	p.E250K	ELF2_uc003ihm.1_Missense_Mutation_p.E202K|ELF2_uc003ihn.1_Missense_Mutation_p.E190K|ELF2_uc003iho.1_Missense_Mutation_p.E173K|ELF2_uc011chc.1_Missense_Mutation_p.E65K	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	262	ETS.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					CCCATGGTTTCATAGTTCATG	0.358			NA											6	46					0	0	0.001984	0	0
CLCN3	1182	broad.mit.edu	37	4	170613428	170613428	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:170613428A>G	uc003isi.2	+	7	1402	c.893A>G	c.(892-894)TAC>TGC	p.Y298C	CLCN3_uc003ish.2_Missense_Mutation_p.Y298C|CLCN3_uc011cjz.1_Missense_Mutation_p.Y281C|CLCN3_uc011cka.1_Missense_Mutation_p.Y298C|CLCN3_uc003isj.1_Missense_Mutation_p.Y271C	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	298	Helical; (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		ATCTTTTCCTACCTCTTTCCA	0.353			NA											8	107					0	0	0.00308	0	0
TRIML1	339976	broad.mit.edu	37	4	189068192	189068192	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr4:189068192G>T	uc003izm.1	+	6	1188	c.1073G>T	c.(1072-1074)TGC>TTC	p.C358F	TRIML1_uc003izn.1_Missense_Mutation_p.C82F	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	358	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GTGGGCATCTGCAAGGACTCT	0.537	Melanoma(31;213 1036 16579 23968 32372)		NA											9	66					0.000274275	0.000311968	0.004482	1	0
TRIP13	9319	broad.mit.edu	37	5	908512	908512	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:908512A>T	uc003jbr.2	+	9	912	c.802A>T	c.(802-804)ACC>TCC	p.T268S	TRIP13_uc010ite.1_Missense_Mutation_p.T268S	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	268					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			CAGGGCGGGCACCGAGCCATC	0.557			NA											8	59					0	0	0.00308	0	0
PRDM9	56979	broad.mit.edu	37	5	23526991	23526991	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:23526991C>A	uc003jgo.2	+	11	1976	c.1794C>A	c.(1792-1794)CAC>CAA	p.H598Q		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	598	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCCTCACTCACCAGAGGACAC	0.597			NA								HNSCC(3;0.000094)			11	104					3.52763e-06	4.31525e-06	0.00499	1	0
CDH10	1008	broad.mit.edu	37	5	24498546	24498546	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:24498546G>T	uc003jgr.1	-	9	1808	c.1476C>A	c.(1474-1476)TTC>TTA	p.F492L	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	492	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AAGTGTCATAGAACACAGCAA	0.398			NA								HNSCC(23;0.051)			8	39					3.09899e-07	3.90131e-07	0.004482	1	0
PDZD2	23037	broad.mit.edu	37	5	32010523	32010523	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:32010523G>A	uc003jhl.2	+	6	1730	c.1342G>A	c.(1342-1344)GAT>AAT	p.D448N	PDZD2_uc003jhm.2_Missense_Mutation_p.D448N|PDZD2_uc011cnx.1_Missense_Mutation_p.D274N	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	448					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTCCTGGACTGATAACGAAGA	0.532			NA											8	76					0	0	0.00308	0	0
DDX4	54514	broad.mit.edu	37	5	55083796	55083796	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:55083796G>A	uc003jqg.3	+	15	1214	c.1140G>A	c.(1138-1140)CAG>CAA	p.Q380Q	DDX4_uc010ivz.2_Silent_p.Q360Q|DDX4_uc003jqh.3_Silent_p.Q346Q|DDX4_uc003jqj.2_Silent_p.Q231Q	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	380	Helicase ATP-binding.			Q -> K (in Ref. 5; AAH47455).	multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGGTCAACCAGATTTATTTGG	0.373			NA											3	28					0	0	0.009096	0	0
CD180	4064	broad.mit.edu	37	5	66479858	66479858	+	Silent	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:66479858G>C	uc003juy.2	-	3	961	c.813C>G	c.(811-813)CTC>CTG	p.L271L		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	271	Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		ACATTTCACAGAGTCCCTTGA	0.463			NA											5	59					0	0	0.000602	0	0
BDP1	55814	broad.mit.edu	37	5	70805797	70805797	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:70805797A>T	uc003kbp.1	+	17	3141	c.2878A>T	c.(2878-2880)ACT>TCT	p.T960S	BDP1_uc003kbn.1_Missense_Mutation_p.T960S|BDP1_uc003kbo.2_Missense_Mutation_p.T960S	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	960	3.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TTTGAAAGCAACTGGAAATGA	0.428			NA											17	59					0	0	0.004007	0	0
SV2C	22987	broad.mit.edu	37	5	75427941	75427941	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:75427941G>C	uc003kei.1	+	2	500	c.366G>C	c.(364-366)GAG>GAC	p.E122D		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	122	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		ACCGGCGGGAGCTGGAATCAG	0.547			NA											8	52					0	0	0.004482	0	0
GPR98	84059	broad.mit.edu	37	5	89985761	89985761	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:89985761G>C	uc003kju.2	+	30	6670	c.6574G>C	c.(6574-6576)GAT>CAT	p.D2192H	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2192	Extracellular (Potential).|Calx-beta 15.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTCATTAATGATATCTATCC	0.393			NA											5	20					0	0	0.000602	0	0
C5orf15	56951	broad.mit.edu	37	5	133295282	133295282	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:133295282G>C	uc003kyo.2	-	2	700	c.569C>G	c.(568-570)TCA>TGA	p.S190*		NM_020199	NP_064584	Q8NC54	KCT2_HUMAN	keratinocytes associated transmembrane protein 2	190	Extracellular (Potential).					integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TTCTATATTTGAGGATGGCAT	0.388			NA											7	50					0	0	0.001984	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432960	140432960	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:140432960C>G	uc003lik.1	+	1	1982	c.1905C>G	c.(1903-1905)GAC>GAG	p.D635E		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGAGAGAGACCCCATGATGC	0.428			NA											7	107					0	0	0.004482	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481446	140481446	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:140481446T>A	uc003lio.2	+	1	1213	c.1213T>A	c.(1213-1215)TCA>ACA	p.S405T	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	405	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCCTAGTGTCAGAAGGCGC	0.468			NA											7	67					0	0	0.001984	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603915	140603915	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:140603915A>T	uc003ljb.2	+	1	838	c.838A>T	c.(838-840)ACA>TCA	p.T280S	PCDHB14_uc011dal.1_Missense_Mutation_p.T127S	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	280	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATATCTTACACATTTTTCCA	0.408	Ovarian(141;50 1831 27899 33809 37648)		NA											5	37					0	0	0.000602	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604343	140604343	+	Silent	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:140604343C>A	uc003ljb.2	+	1	1266	c.1266C>A	c.(1264-1266)ACC>ACA	p.T422T	PCDHB14_uc011dal.1_Silent_p.T269T	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	422	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCACGATCACCGTCACAGACT	0.498	Ovarian(141;50 1831 27899 33809 37648)		NA											10	141					0.00621372	0.00678971	0.006214	1	0
SLC25A2	83884	broad.mit.edu	37	5	140683204	140683204	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:140683204C>T	uc003ljf.2	-	1	409	c.229G>A	c.(229-231)GAA>AAA	p.E77K		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	77	Helical; Name=2; (Potential).|Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	ACCGAGTTTTCGGCGACGTAG	0.577			NA											15	84					0	0	0.00245	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710633	140710633	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:140710633G>A	uc003lji.1	+	1	382	c.382G>A	c.(382-384)GAC>AAC	p.D128N	PCDHGA1_uc011dan.1_Missense_Mutation_p.D128N	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	128	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATATTAATGACAACACTCC	0.403			NA											24	130					0	0	0.003954	0	0
SPINK5	11005	broad.mit.edu	37	5	147473998	147473998	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:147473998G>C	uc003lox.2	+	9	821	c.748G>C	c.(748-750)GAC>CAC	p.D250H	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.D222H|SPINK5_uc010jgr.2_Missense_Mutation_p.D231H|SPINK5_uc003low.2_Missense_Mutation_p.D250H|SPINK5_uc003loy.2_Missense_Mutation_p.D250H	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	250	Kazal-like 4.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGTGGCCCTGACGGCAGGAT	0.423			NA											4	94					0	0	0.000602	0	0
SH3TC2	79628	broad.mit.edu	37	5	148411177	148411177	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:148411177C>G	uc003lpu.2	-	9	1227	c.1075G>C	c.(1075-1077)GAG>CAG	p.E359Q	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_5'UTR|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.E352Q|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.E244Q	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	359							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGAACACTCAGTCTGCTTA	0.537			NA											6	39					0	0	0.001168	0	0
ABLIM3	22885	broad.mit.edu	37	5	148632354	148632354	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:148632354G>A	uc003lpy.2	+	23	2143	c.1892G>A	c.(1891-1893)AGA>AAA	p.R631K	ABLIM3_uc003lpz.1_Missense_Mutation_p.R631K|ABLIM3_uc003lqa.1_Missense_Mutation_p.R528K|ABLIM3_uc003lqb.2_Missense_Mutation_p.R520K|ABLIM3_uc003lqc.1_Missense_Mutation_p.R598K|ABLIM3_uc003lqd.1_Missense_Mutation_p.R536K|ABLIM3_uc003lqf.2_Missense_Mutation_p.R520K|ABLIM3_uc003lqe.1_Missense_Mutation_p.R520K	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	631	HP.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGACTACAAGAGGAAGAAAC	0.488			NA											5	75					0	0	0.000602	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025501	176025501	+	Silent	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:176025501C>A	uc003meo.1	-	2	1510	c.1335G>T	c.(1333-1335)GTG>GTT	p.V445V		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	445						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCCTTTCCCACAGACACAC	0.532			NA											11	97					0.00010058	0.0001161	0.001368	1	0
MAML1	9794	broad.mit.edu	37	5	179192956	179192956	+	Silent	SNP	A	A	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr5:179192956A>G	uc003mkm.2	+	2	1208	c.945A>G	c.(943-945)CCA>CCG	p.P315P	MAML1_uc003mkn.1_Silent_p.P315P	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	315					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGGCTCTCCACAAGTGAGGG	0.552			NA											4	64					0	0	0.009096	0	0
RIPK1	8737	broad.mit.edu	37	6	3081338	3081338	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:3081338C>T	uc010jni.2	+	4	679	c.447C>T	c.(445-447)GAC>GAT	p.D149D	RIPK1_uc003muv.3_5'UTR|RIPK1_uc003muw.3_Silent_p.D84D|RIPK1_uc011dhs.1_Intron|RIPK1_uc003mux.2_Silent_p.D149D	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	149	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TTGATAATGACTTCCACATTA	0.378			NA											3	34					0	0	0.004672	0	0
KDM1B	221656	broad.mit.edu	37	6	18222215	18222215	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:18222215G>A	uc003nco.1	+	15	1927	c.1852G>A	c.(1852-1854)GCA>ACA	p.A618T	KDM1B_uc003ncn.1_Missense_Mutation_p.A589T|KDM1B_uc003ncp.1_Missense_Mutation_p.A174T|KDM1B_uc003ncq.1_Missense_Mutation_p.S172N	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	821					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						CAAGATTGCAGCATTTTAAGA	0.408			NA											5	51					0	0	0.000602	0	0
BTN2A2	10385	broad.mit.edu	37	6	26385379	26385379	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:26385379C>T	uc003nhq.2	+	3	317	c.231C>T	c.(229-231)CCC>CCT	p.P77P	BTN2A2_uc011dkf.1_Intron|BTN2A2_uc011dkg.1_Silent_p.P77P|BTN2A2_uc003nhr.2_Intron|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Silent_p.P77P|BTN2A2_uc003nht.2_Silent_p.P77P	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	77	Extracellular (Potential).|Ig-like V-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						AGTTCTCCCCCGCAGTGTTTG	0.532			NA											4	71					0	0	0.009096	0	0
OR2J3	442186	broad.mit.edu	37	6	29079946	29079946	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:29079946G>T	uc011dll.1	+	1	279	c.279G>T	c.(277-279)AAG>AAT	p.K93N		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCCGGAAAAGACCATCTCTT	0.478			NA											12	159					2.80697e-09	3.6889e-09	0.010729	1	0
ZBTB12	221527	broad.mit.edu	37	6	31869005	31869005	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:31869005G>A	uc003nyd.1	-	2	254	c.78C>T	c.(76-78)CTC>CTT	p.L26L	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_Intron	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	26					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTCTGCCCGGAGCTGGTTCA	0.657			NA											4	36					0	0	0.009096	0	0
EGFL8	80864	broad.mit.edu	37	6	32134567	32134567	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:32134567C>A	uc003oab.1	+	4	372	c.314C>A	c.(313-315)CCG>CAG	p.P105Q	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.P105Q	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	105	EMI.					extracellular region|integral to membrane	calcium ion binding				0						AAGCGGCACCCGGGGGCGCTC	0.667			NA											3	43					0.004672	0.00511946	0.004672	1	0
CPNE5	57699	broad.mit.edu	37	6	36710137	36710137	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:36710137G>A	uc003omr.1	-	21	1757	c.1690C>T	c.(1690-1692)CGC>TGC	p.R564C	CPNE5_uc003omp.1_Missense_Mutation_p.R272C|CPNE5_uc010jwn.1_Missense_Mutation_p.R214C|CPNE5_uc003omq.1_Missense_Mutation_p.R214C	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	564										skin(1)	1						GGACGCGGGCGAATGCCCTGT	0.687			NA											6	102					0	0	0.001168	0	0
BTBD9	114781	broad.mit.edu	37	6	38562074	38562074	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:38562074G>C	uc003ooa.3	-	4	791	c.215C>G	c.(214-216)TCT>TGT	p.S72C	BTBD9_uc003ony.3_Missense_Mutation_p.S4C|BTBD9_uc010jwv.2_Missense_Mutation_p.S4C|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.S72C	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	72	BTB.				cell adhesion						0						TTCAGGCTGAGACTCTCGCAT	0.428			NA											6	68					0	0	0.001168	0	0
TREM2	54209	broad.mit.edu	37	6	41126515	41126515	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:41126515A>C	uc003opy.2	-	5	782	c.680T>G	c.(679-681)CTG>CGG	p.L227R	TREM2_uc003opz.2_3'UTR|TREM2_uc010jxl.1_Silent_p.A192A	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	227	Cytoplasmic (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					CGTGTCTCTCAGCCCTGCAAT	0.617			NA											10	93					0	0	0.006214	0	0
GPR116	221395	broad.mit.edu	37	6	46826925	46826925	+	Silent	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:46826925G>C	uc003oyo.3	-	17	3004	c.2715C>G	c.(2713-2715)CTC>CTG	p.L905L	GPR116_uc011dwj.1_Silent_p.L460L|GPR116_uc011dwk.1_Silent_p.L334L|GPR116_uc003oyp.3_Silent_p.L763L|GPR116_uc003oyq.3_Silent_p.L905L|GPR116_uc010jzi.1_Silent_p.L577L	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	905	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			GGATGGCTTGGAGAGTTGGGA	0.453	NSCLC(59;410 1274 8751 36715 50546)		NA											8	64					0	0	0.00308	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55378876	55378876	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:55378876G>T	uc003pcn.2	-	6	761	c.602C>A	c.(601-603)TCT>TAT	p.S201Y	HMGCLL1_uc003pco.2_Missense_Mutation_p.S171Y|HMGCLL1_uc010jzx.2_Missense_Mutation_p.S72Y|HMGCLL1_uc011dxc.1_Missense_Mutation_p.S139Y|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron|HMGCLL1_uc003pcp.2_Missense_Mutation_p.S139Y	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	201							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GTGTCTTGCAGACTTAACAAC	0.338	Ovarian(35;840 893 7837 15538 42887)		NA											6	32					5.9392e-07	7.45274e-07	0.001168	1	0
BAI3	577	broad.mit.edu	37	6	70070957	70070957	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:70070957G>T	uc003pev.3	+	29	4240	c.3792G>T	c.(3790-3792)GAG>GAT	p.E1264D	BAI3_uc010kak.2_Missense_Mutation_p.E1264D|BAI3_uc011dxx.1_Missense_Mutation_p.E470D	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1264	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GTATGAATGAGCTTAGCAATC	0.423			NA											11	33					4.68919e-08	6.00031e-08	0.008291	1	0
CNR1	1268	broad.mit.edu	37	6	88854258	88854258	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:88854258C>T	uc011dzq.1	-	2	4299	c.736G>A	c.(736-738)GTG>ATG	p.V246M	CNR1_uc010kbz.2_Missense_Mutation_p.V246M|CNR1_uc011dzr.1_Missense_Mutation_p.V246M|CNR1_uc011dzs.1_Missense_Mutation_p.V246M|CNR1_uc003pmq.3_Missense_Mutation_p.V246M|CNR1_uc011dzt.1_Missense_Mutation_p.V246M|CNR1_uc010kca.2_Missense_Mutation_p.V213M	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	246	Helical; Name=4; (Potential).			V -> A (in Ref. 5; AAD34320).	G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ACGGCGATCACAATGGCTATG	0.527			NA											7	57					0	0	0.00308	0	0
MANEA	79694	broad.mit.edu	37	6	96034645	96034645	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:96034645G>T	uc003poo.1	+	2	470	c.330G>T	c.(328-330)TGG>TGT	p.W110C	MANEA_uc003pon.2_Missense_Mutation_p.W110C	NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	110	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ATTACAGTTGGTATGGAAATC	0.363			NA											7	39					8.12818e-05	9.4384e-05	0.001984	1	0
HSF2	3298	broad.mit.edu	37	6	122744757	122744757	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:122744757G>C	uc003pyu.2	+	10	1289	c.1102G>C	c.(1102-1104)GAC>CAC	p.D368H	HSF2_uc003pyv.2_Missense_Mutation_p.D368H	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	368	Hydrophobic repeat HR-C.				response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TGACAGTATTGACTGCAGTTT	0.338			NA											7	61					0	0	0.004482	0	0
VTA1	51534	broad.mit.edu	37	6	142468513	142468513	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:142468513G>A	uc003qiw.2	+	1	104	c.89G>A	c.(88-90)CGA>CAA	p.R30Q	VTA1_uc011edt.1_RNA|VTA1_uc011edu.1_Missense_Mutation_p.E4K	NM_016485	NP_057569	Q9NP79	VTA1_HUMAN	Vps20-associated 1 homolog	30	Interaction with CHMP5.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding				0	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		CATGACAAGCGAGACCCTGTG	0.582			NA									OREG0017699	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	23					0	0	0.004672	0	0
SYNJ2	8871	broad.mit.edu	37	6	158492658	158492658	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:158492658G>C	uc003qqx.1	+	15	2040	c.1965G>C	c.(1963-1965)AAG>AAC	p.K655N	SYNJ2_uc003qqw.1_Missense_Mutation_p.K655N|SYNJ2_uc003qqy.1_Missense_Mutation_p.K368N|SYNJ2_uc003qqz.1_Missense_Mutation_p.K272N|SYNJ2_uc003qra.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	655	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		ACACAGTGAAGACGGGCATGG	0.612			NA											6	75					0	0	0.001984	0	0
TAGAP	117289	broad.mit.edu	37	6	159456967	159456967	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:159456967G>T	uc003qrz.2	-	10	2420	c.2088C>A	c.(2086-2088)ACC>ACA	p.T696T	TAGAP_uc011eft.1_Silent_p.T633T|TAGAP_uc003qsa.2_Silent_p.T518T	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	696					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ACTCGGAGACGGTCCTCAGCG	0.582			NA											10	38					2.17888e-05	2.592e-05	0.006214	1	0
PLG	5340	broad.mit.edu	37	6	161127552	161127552	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr6:161127552G>T	uc003qtm.3	+	2	226	c.163G>T	c.(163-165)GAG>TAG	p.E55*		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	55	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAAATGTGAGGAGGACGAAGA	0.428			NA											18	99					1.01871e-10	1.35712e-10	0.008871	1	0
TTYH3	80727	broad.mit.edu	37	7	2696097	2696097	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:2696097C>T	uc003smp.2	+	11	1366	c.1179C>T	c.(1177-1179)CTC>CTT	p.L393L	TTYH3_uc010ksn.2_Silent_p.L113L|TTYH3_uc003smq.2_Silent_p.L222L	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	393	Helical; Name=5; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		ACCTGGCCCTCTTCTCCTTCG	0.627			NA											10	84					0	0	0.006214	0	0
GNA12	2768	broad.mit.edu	37	7	2771079	2771079	+	Silent	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:2771079G>A	uc003smu.2	-	4	1046	c.882C>T	c.(880-882)TTC>TTT	p.F294F	GNA12_uc011jwb.1_Silent_p.F277F|GNA12_uc003smt.2_Silent_p.F235F	NM_007353	NP_031379	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein)	294					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		TCTTGTTGAGGAAGAGAATGA	0.557			NA											6	64					0	0	0.001168	0	0
ADCY1	107	broad.mit.edu	37	7	45614412	45614412	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:45614412G>T	uc003tne.3	+	1	288	c.270G>T	c.(268-270)CTG>CTT	p.L90L	ADCY1_uc003tnd.2_Intron	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	90	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	cgcccggccTGGCCAAGGGCT	0.622			NA											4	20					0.00024832	0.000283274	0.009096	1	0
TRRAP	8295	broad.mit.edu	37	7	98528293	98528293	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:98528293G>C	uc003upp.2	+	25	3640	c.3431G>C	c.(3430-3432)CGC>CCC	p.R1144P	TRRAP_uc011kis.1_Missense_Mutation_p.R1144P|TRRAP_uc003upr.2_Missense_Mutation_p.R836P	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1144					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATCGTGGAGCGCCTGTGTGCA	0.458			NA											16	186					0	0	0.004007	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621545	99621545	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:99621545C>T	uc003usk.1	+	2	635	c.416C>T	c.(415-417)TCA>TTA	p.S139L	ZKSCAN1_uc003usj.2_Missense_Mutation_p.S138L|ZKSCAN1_uc003usl.1_Missense_Mutation_p.S103L|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	139					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CTTGATTTATCAGGACAACAG	0.507			NA											7	68					0	0	0.00308	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509705	106509705	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:106509705C>G	uc003vdv.3	+	2	1784	c.1699C>G	c.(1699-1701)CTC>GTC	p.L567V	PIK3CG_uc003vdu.2_Missense_Mutation_p.L567V|PIK3CG_uc003vdw.2_Missense_Mutation_p.L567V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	567					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACTTAACCCTCTCACAGCAGA	0.502			NA											5	55					0	0	0.000602	0	0
CADPS2	93664	broad.mit.edu	37	7	122131426	122131426	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:122131426C>T	uc010lkp.2	-	10	1754	c.1591G>A	c.(1591-1593)GAA>AAA	p.E531K	CADPS2_uc003vkg.3_Missense_Mutation_p.E231K|CADPS2_uc010lkq.2_Missense_Mutation_p.E531K	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	531	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TCTTGTGGTTCAGACTTCTTT	0.353			NA											3	6					0	0	0.004672	0	0
ADCK2	90956	broad.mit.edu	37	7	140390572	140390572	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:140390572A>C	uc003vvy.1	+	7	1877	c.1699A>C	c.(1699-1701)AGC>CGC	p.S567R	ADCK2_uc003vvz.2_Missense_Mutation_p.S567R	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	567	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					TCATGTGTCCAGCCTTCTCTC	0.547			NA											26	294					0	0	0.00632	0	0
SSPO	23145	broad.mit.edu	37	7	149528279	149528279	+	Silent	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr7:149528279G>T	uc010lpk.2	+	110	15195	c.15195G>T	c.(15193-15195)GGG>GGT	p.G5065G	SSPO_uc003wgh.2_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	5065	CTCK.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCACCAAAGGGACCTGTTACC	0.617			NA											4	24					1.23904e-05	1.49685e-05	0.000602	1	0
RP1L1	94137	broad.mit.edu	37	8	10468390	10468390	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:10468390C>A	uc003wtc.2	-	4	3447	c.3218G>T	c.(3217-3219)CGG>CTG	p.R1073L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1073					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGAAGTGCCCGCAGGCTCAC	0.697			NA											5	21					0.000602214	0.000673165	0.000602	1	0
LZTS1	11178	broad.mit.edu	37	8	20110421	20110422	+	Nonsense_Mutation	DNP	CC	CC	AA	rs147904321		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:20110421_20110422CC>AA	uc003wzr.2	-	2	1131_1132	c.1020_1021GG>TT	c.(1018-1023)CAGGAG>CATTAG	p.340_341QE>H*	LZTS1_uc010ltg.1_Nonsense_Mutation_p.340_341QE>H*	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	340_341	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TGCCGCTTCTCCTGCTGAAGCT	0.644			NA											4	32					0	0	0.004672	0	0
KCNU1	157855	broad.mit.edu	37	8	36766899	36766899	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:36766899C>G	uc010lvw.2	+	21	2264	c.2177C>G	c.(2176-2178)TCA>TGA	p.S726*	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	726	Segment S9.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GATGCCCACTCAGCCCCGATG	0.468			NA											33	236					0	0	0.004289	0	0
TRIB1	10221	broad.mit.edu	37	8	126448348	126448348	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:126448348G>T	uc003yrx.2	+	3	1336	c.754G>T	c.(754-756)GAG>TAG	p.E252*	TRIB1_uc011lis.1_Nonsense_Mutation_p.E86*|TRIB1_uc010mdn.2_Nonsense_Mutation_p.E21*	NM_025195	NP_079471	Q96RU8	TRIB1_HUMAN	G-protein-coupled receptor induced protein	252	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			lung(1)	1	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			CGTGAGCCCTGAGATCCTCAA	0.532			NA											5	62					1.23904e-05	1.49685e-05	0.000602	1	0
TMEM71	137835	broad.mit.edu	37	8	133759318	133759318	+	Silent	SNP	A	A	G	rs74775484	byFrequency	TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:133759318A>G	uc003ytp.2	-	5	586	c.357T>C	c.(355-357)TCT>TCC	p.S119S	TMEM71_uc003ytm.1_5'UTR|TMEM71_uc003ytn.2_Intron|TMEM71_uc003yto.2_Silent_p.S119S	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	119						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GGTTGAAGAGAGAAGAAAAGG	0.393			NA											3	54					0	0	0.004672	0	0
TG	7038	broad.mit.edu	37	8	133883593	133883593	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:133883593G>T	uc003ytw.2	+	4	316	c.275G>T	c.(274-276)TGT>TTT	p.C92F		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	92	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTACCCACAGGTCTGTCATTT	0.507			NA											13	95					1.5842e-08	2.06105e-08	0.001855	1	0
EPPK1	83481	broad.mit.edu	37	8	144945369	144945369	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:144945369C>G	uc003zaa.1	-	1	2066	c.2053G>C	c.(2053-2055)GAG>CAG	p.E685Q		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	685	Plectin 13.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACAGCGCGCTCAGCCGACAGC	0.612			NA											6	50					0	0	0.001168	0	0
GPT	2875	broad.mit.edu	37	8	145730156	145730156	+	Silent	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:145730156C>G	uc011lli.1	+	4	412	c.255C>G	c.(253-255)GTC>GTG	p.V85V	GPT_uc011llj.1_Silent_p.V85V|GPT_uc003zdh.3_Silent_p.V85V	NM_005309	NP_005300	P24298	ALAT1_HUMAN	glutamic pyruvate transaminase	85					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|central_nervous_system(1)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTTCCCAGGTCTTGGCCCTCT	0.647			NA											29	296					0	0	0.009535	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145770662	145770662	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:145770662C>A	uc003zdt.1	-	7	3047	c.2492G>T	c.(2491-2493)CGG>CTG	p.R831L	ARHGAP39_uc011llk.1_Missense_Mutation_p.R831L|ARHGAP39_uc003zds.1_Missense_Mutation_p.R831L	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	831	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GTCCATGTGCCGGTAGATGTA	0.627			NA											12	46					3.07112e-06	3.78058e-06	0.010729	1	0
KIAA1432	57589	broad.mit.edu	37	9	5763244	5763244	+	Silent	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr9:5763244G>C	uc003zji.2	+	18	2073	c.1980G>C	c.(1978-1980)CTG>CTC	p.L660L	KIAA1432_uc003zjh.2_Silent_p.L660L|KIAA1432_uc003zjl.3_Silent_p.L623L|KIAA1432_uc003zjj.1_Silent_p.L202L	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	739						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCCTCTGGCTGAGCTGTGGTG	0.532			NA											5	114					0	0	0.000602	0	0
PRUNE2	158471	broad.mit.edu	37	9	79520851	79520851	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr9:79520851G>C	uc010mpk.2	-	1	153	c.29C>G	c.(28-30)TCT>TGT	p.S10C	PRUNE2_uc004akn.2_Missense_Mutation_p.S10C	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	10					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TACCAGTTTAGATTTGGCGCG	0.532			NA											7	65					0	0	0.001984	0	0
C9orf129	445577	broad.mit.edu	37	9	96080730	96080730	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr9:96080730G>A	uc010mre.2	-	5	905	c.541C>T	c.(541-543)CCG>TCG	p.P181S	WNK2_uc011lud.1_3'UTR|WNK2_uc004atj.2_Intron|WNK2_uc004atk.2_3'UTR	NM_001098808	NP_001092278	Q5T035	CI129_HUMAN	hypothetical protein LOC445577	181										ovary(1)	1						CACACTGGCGGAGCTGCTTGC	0.612			NA											8	86					0	0	0.006214	0	0
COL27A1	85301	broad.mit.edu	37	9	116930955	116930955	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr9:116930955G>T	uc011lxl.1	+	3	1120	c.1120G>T	c.(1120-1122)GCC>TCC	p.A374S	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.A224S	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	374	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CAAGCCTTCGGCCCCTTCTAC	0.537			NA											10	99					1.58986e-06	1.96961e-06	0.008291	1	0
CEP110	11064	broad.mit.edu	37	9	123919802	123919802	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr9:123919802G>C	uc004bkx.1	+	26	4451	c.4420G>C	c.(4420-4422)GAG>CAG	p.E1474Q	CEP110_uc004bla.1_Missense_Mutation_p.E922Q|CEP110_uc010mvo.1_Missense_Mutation_p.E143Q|CEP110_uc004blb.1_Missense_Mutation_p.E143Q|CEP110_uc010mvp.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1474	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ATTGCAAACTGAGTCAGATGC	0.408			NA											4	41					0	0	0.009096	0	0
DMD	1756	broad.mit.edu	37	X	32841411	32841411	+	Splice_Site	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:32841411C>A	uc004dda.1	-	5	601	c.357_splice	c.e5+1	p.Q119_splice	DMD_uc004dcz.2_Splice_Site|DMD_uc004dcy.1_Splice_Site_p.Q115_splice|DMD_uc004ddb.1_Splice_Site_p.Q111_splice|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Splice_Site_p.Q111_splice|DMD_uc010ngq.1_Splice_Site|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGGATTCTTACCTGCCAGTGG	0.328			NA											5	113					3.59834e-05	4.24167e-05	0.001168	1	0
ZNF41	7592	broad.mit.edu	37	X	47306910	47306910	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:47306910C>G	uc004dhs.3	-	4	2452	c.2385G>C	c.(2383-2385)CAG>CAC	p.Q795H	ZNF41_uc004dhu.3_Missense_Mutation_p.Q787H|ZNF41_uc004dht.3_Missense_Mutation_p.Q667H|ZNF41_uc004dhv.3_Missense_Mutation_p.Q763H|ZNF41_uc004dhw.3_Missense_Mutation_p.Q755H|ZNF41_uc004dhy.3_Missense_Mutation_p.Q753H|ZNF41_uc004dhx.3_Missense_Mutation_p.Q753H|ZNF41_uc011mlm.1_Missense_Mutation_p.Q667H	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	795	C2H2-type 18.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TAAAGGCCTTCTGACATTCTG	0.383			NA											13	70					0	0	0.001368	0	0
HUWE1	10075	broad.mit.edu	37	X	53591666	53591666	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:53591666C>G	uc004dsp.2	-	51	7300	c.6898G>C	c.(6898-6900)GAA>CAA	p.E2300Q	HUWE1_uc004dsn.2_Missense_Mutation_p.E1124Q	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2300	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCCTGCACTTCTGCTTCCCCA	0.517			NA											5	107					0	0	0.001984	0	0
HUWE1	10075	broad.mit.edu	37	X	53616620	53616620	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:53616620G>T	uc004dsp.2	-	36	4750	c.4348C>A	c.(4348-4350)CTT>ATT	p.L1450I	HUWE1_uc004dsn.2_Missense_Mutation_p.L275I	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1450					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCATCAAGAAGGTGGAAGCAG	0.468			NA											9	93					0.00448238	0.00493951	0.004482	1	0
MTMR8	55613	broad.mit.edu	37	X	63445529	63445529	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:63445529A>T	uc011mou.1	-	10	1195	c.1127T>A	c.(1126-1128)ATG>AAG	p.M376K	ASB12_uc004dvp.1_5'Flank|ASB12_uc004dvq.1_Missense_Mutation_p.M1K|ASB12_uc004dvr.1_Missense_Mutation_p.M1K	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AACTATTCTCATTATGAGCAC	0.493			NA											3	8					0	0	0.004672	0	0
VSIG4	11326	broad.mit.edu	37	X	65253491	65253491	+	Silent	SNP	C	C	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:65253491C>T	uc004dwh.2	-	2	364	c.237G>A	c.(235-237)CAG>CAA	p.Q79Q	VSIG4_uc004dwi.2_Silent_p.Q79Q|VSIG4_uc010nkq.1_Silent_p.Q79Q|VSIG4_uc004dwj.2_Silent_p.Q79Q|VSIG4_uc011moy.1_Silent_p.Q79Q|VSIG4_uc004dwk.2_Silent_p.Q79Q|VSIG4_uc004dwl.2_5'UTR	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	79	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						GGTACTTTGCCTGCTGGATAT	0.547			NA											13	101					0	0	0.001855	0	0
AR	367	broad.mit.edu	37	X	66863140	66863140	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:66863140C>G	uc004dwu.1	+	2	2774	c.1659C>G	c.(1657-1659)TAC>TAG	p.Y553*	AR_uc011mpd.1_Nonsense_Mutation_p.Y553*|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Nonsense_Mutation_p.Y553*|AR_uc004dwv.1_Nonsense_Mutation_p.Y21*	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	552	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TTGACTATTACTTTCCACCCC	0.468			NA							Androgen_Insensitivity_Syndrome				7	58					0	0	0.00308	0	0
RLIM	51132	broad.mit.edu	37	X	73811920	73811920	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:73811920C>G	uc004ebu.2	-	5	1520	c.1230G>C	c.(1228-1230)ATG>ATC	p.M410I	RLIM_uc004ebw.2_Missense_Mutation_p.M410I	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	410					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CAAAACCTGTCATTATCTGCC	0.408	Esophageal Squamous(169;1899 1923 14997 18818 32118)		NA											8	91					0	0	0.004482	0	0
P2RY10	27334	broad.mit.edu	37	X	78216469	78216469	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:78216469G>C	uc004ede.2	+	4	821	c.452G>C	c.(451-453)GGC>GCC	p.G151A	P2RY10_uc004edf.2_Missense_Mutation_p.G151A	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	151	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						TACGATGTGGGCATCAGTGCT	0.498			NA											23	71					0	0	0.012319	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529098	102529098	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:102529098G>A	uc004ejz.1	-	3	689	c.394C>T	c.(394-396)CAG>TAG	p.Q132*		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						AAGTCCTCCTGAGAGTCCTTG	0.532			NA											6	166					0	0	0.001984	0	0
MID2	11043	broad.mit.edu	37	X	107160843	107160843	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:107160843C>A	uc004enl.2	+	7	1882	c.1309C>A	c.(1309-1311)CAG>AAG	p.Q437K	MID2_uc004enk.2_Missense_Mutation_p.Q437K	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	437	Fibronectin type-III.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CTATGAGCTTCAGTACACCAT	0.488			NA											18	274					3.52763e-06	4.31525e-06	0.00499	1	0
ALG13	79868	broad.mit.edu	37	X	110951607	110951607	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:110951607G>T	uc011msy.1	+	4	770	c.736G>T	c.(736-738)GCC>TCC	p.A246S	ALG13_uc011msw.1_Missense_Mutation_p.A168S|ALG13_uc011msx.1_Missense_Mutation_p.A142S|ALG13_uc011msz.1_Missense_Mutation_p.A168S|ALG13_uc011mta.1_Missense_Mutation_p.A142S|ALG13_uc011mtb.1_Missense_Mutation_p.A142S			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	246	OTU.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						CCTCTTTCGGGCCATTTCGGA	0.448			NA											12	146					7.93312e-07	9.92278e-07	0.00245	1	0
ATP1B4	23439	broad.mit.edu	37	X	119513442	119513442	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:119513442G>A	uc004esr.2	+	8	1111	c.1027G>A	c.(1027-1029)GAT>AAT	p.D343N	ATP1B4_uc004esq.2_Missense_Mutation_p.D339N|ATP1B4_uc011mtx.1_Missense_Mutation_p.D308N|ATP1B4_uc011mty.1_Missense_Mutation_p.D300N	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	343	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						TGTCATCAATGATCGTTTTGT	0.453			NA											6	84					0	0	0.001168	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685379	125685379	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:125685379C>A	uc004eul.2	-	1	1464	c.1213G>T	c.(1213-1215)GCC>TCC	p.A405S		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	405										skin(3)|ovary(1)	4						CTGCCACAGGCAAGCCTGAGC	0.557			NA											15	110					1.5739e-10	2.08958e-10	0.004007	1	0
SMARCA1	6594	broad.mit.edu	37	X	128599538	128599538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:128599538G>A	uc004eun.3	-	23	3102	c.2989C>T	c.(2989-2991)CAG>TAG	p.Q997*	SMARCA1_uc004eup.3_Nonsense_Mutation_p.Q985*|SMARCA1_uc011muk.1_Nonsense_Mutation_p.Q997*|SMARCA1_uc011mul.1_Nonsense_Mutation_p.Q985*	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	997	SANT 2.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						AATCTAAACTGGGGAGCATTT	0.338			NA											5	66					0	0	0.000602	0	0
ELF4	2000	broad.mit.edu	37	X	129201451	129201451	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:129201451A>C	uc004evd.3	-	9	1622	c.1237T>G	c.(1237-1239)TCG>GCG	p.S413A	ELF4_uc004eve.3_Missense_Mutation_p.S413A	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	413					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCGAGCCCGACCCCACGGGG	0.597			NA	T	ERG	AML								4	95					0	0	0.009096	0	0
USP26	83844	broad.mit.edu	37	X	132160973	132160973	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:132160973C>G	uc010nrm.1	-	6	1746	c.1276G>C	c.(1276-1278)GAC>CAC	p.D426H	USP26_uc011mvf.1_Missense_Mutation_p.D426H	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	426					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					CCACTGGTGTCAGGATCATCA	0.378	NSCLC(104;342 1621 36940 47097 52632)		NA											11	80					0	0	0.008291	0	0
GPR112	139378	broad.mit.edu	37	X	135426905	135426905	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:135426905C>A	uc004ezu.1	+	6	1331	c.1040C>A	c.(1039-1041)TCT>TAT	p.S347Y	GPR112_uc010nsb.1_Missense_Mutation_p.S142Y|GPR112_uc010nsc.1_Missense_Mutation_p.S114Y	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	347	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AAATCTCCATCTTCAGAAAGC	0.393			NA											6	47					0.00116845	0.00129864	0.001168	1	0
RBMX	27316	broad.mit.edu	37	X	135960088	135960088	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:135960088C>A	uc004fae.1	-	4	584	c.374G>T	c.(373-375)CGG>CTG	p.R125L	RBMX_uc011mwf.1_Intron|RBMX_uc004fad.1_Missense_Mutation_p.R125L|RBMX_uc011mwg.1_Missense_Mutation_p.R86L|RBMX_uc004faf.1_Intron|RBMX_uc010nsf.1_Missense_Mutation_p.R86L|RBMX_uc004fag.1_5'UTR	NM_002139	NP_002130	P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked isoform 1	125						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GTGTCCTCCCCGTGAGGGAGG	0.547			NA											7	76					8.12818e-05	9.4384e-05	0.001984	1	0
ATP11C	286410	broad.mit.edu	37	X	138827966	138827966	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:138827966G>T	uc004faz.2	-	25	2987	c.2888C>A	c.(2887-2889)ACA>AAA	p.T963K	ATP11C_uc004fax.2_Missense_Mutation_p.T171K|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.T963K	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	963	Helical; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					AGCCAGAAATGTCCAATATAA	0.393			NA											8	62					1.06961e-07	1.35974e-07	0.00308	1	0
LDOC1	23641	broad.mit.edu	37	X	140270995	140270995	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:140270995G>C	uc004fbj.2	-	1	316	c.212C>G	c.(211-213)ACG>AGG	p.T71R		NM_012317	NP_036449	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	71					negative regulation of cell proliferation	nucleus	protein binding				0	Acute lymphoblastic leukemia(192;7.65e-05)					GTAAGACGCCGTCTGCACGAT	0.622			NA											9	91					0	0	0.004482	0	0
AFF2	2334	broad.mit.edu	37	X	148037467	148037467	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:148037467C>A	uc004fcp.2	+	11	2371	c.1892C>A	c.(1891-1893)CCC>CAC	p.P631H	AFF2_uc004fcq.2_Missense_Mutation_p.P621H|AFF2_uc004fcr.2_Missense_Mutation_p.P592H|AFF2_uc011mxb.1_Missense_Mutation_p.P596H|AFF2_uc004fcs.2_Missense_Mutation_p.P598H|AFF2_uc011mxc.1_Missense_Mutation_p.P272H	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	631					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AAAAAACAGCCCAAAAAAGTT	0.433			NA											15	134					0.00244969	0.0027149	0.00245	1	0
GABRE	2564	broad.mit.edu	37	X	151124235	151124235	+	Silent	SNP	G	G	C			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:151124235G>C	uc004ffi.2	-	7	936	c.882C>G	c.(880-882)CTC>CTG	p.L294L	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	294	Helical; (Potential).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AAACCCAGGAGAGCATCGTGG	0.498			NA											7	105					0	0	0.001984	0	0
GABRE	2564	broad.mit.edu	37	X	151128375	151128375	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:151128375C>A	uc004ffi.2	-	6	774	c.720G>T	c.(718-720)TGG>TGT	p.W240C	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA|MIR224_hsa-mir-224|MI0000301_5'Flank|MIR452_hsa-mir-452|MI0001733_5'Flank	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	240	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGAAGAGCTTCCAGGAGTTCT	0.443			NA											8	81					0.000157383	0.000180065	0.00308	1	0
F8	2157	broad.mit.edu	37	X	154221309	154221309	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chrX:154221309G>A	uc004fmt.2	-	4	674	c.503C>T	c.(502-504)TCT>TTT	p.S168F	F8_uc011mzx.1_Missense_Mutation_p.S133F	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	168	Plastocyanin-like 1.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAGTGGGTCAGAGGCCATTGG	0.463			NA											16	193					0	0	0.006122	0	0
IRF2BP2	359948	broad.mit.edu	37	1	234743316	234743317	+	Frame_Shift_Ins	INS	-	-	CT			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:234743316_234743317insCT	uc001hwg.2	-	2	1361_1362	c.1330_1331insAG	c.(1330-1332)GCCfs	p.A444fs	IRF2BP2_uc009xfw.2_Frame_Shift_Ins_p.A54fs|IRF2BP2_uc001hwf.2_Frame_Shift_Ins_p.A428fs	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			AACCTGGTTGGCATCTTTTGAG	0.604			NA											11	164	---	---	---	---	NA	NA	NA	NA	NA
OR2M2	391194	broad.mit.edu	37	1	248343457	248343457	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr1:248343457delC	uc010pzf.1	+	1	170	c.170delC	c.(169-171)ACCfs	p.T57fs		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAGCTCCACACCCCCATGTAC	0.537			NA											31	392	---	---	---	---	NA	NA	NA	NA	NA
ZNF585A	199704	broad.mit.edu	37	19	37643721	37643721	+	Frame_Shift_Del	DEL	C	C	-	rs146669317		TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr19:37643721delC	uc002ofo.1	-	5	1311	c.1080delG	c.(1078-1080)GGGfs	p.G360fs	ZNF585A_uc002ofm.1_Frame_Shift_Del_p.G305fs|ZNF585A_uc002ofn.1_Frame_Shift_Del_p.G305fs	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	360	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAAAGGCCTTCCCACACTCAG	0.408			NA											26	73	---	---	---	---	NA	NA	NA	NA	NA
FLRT3	23767	broad.mit.edu	37	20	14306373	14306375	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	AAG	AAG	-	-	AAG	AAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr20:14306373_14306375delAAG	uc002wov.1	-	3	2245_2247	c.1778_1780delCTT	c.(1777-1782)TCTTTT>TTT	p.S593del	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_In_Frame_Del_p.S593del	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	593	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		AACATCTGAAAAGAAGTTTCCCT	0.399			NA											16	137	---	---	---	---	NA	NA	NA	NA	NA
EPHB1	2047	broad.mit.edu	37	3	134851761	134851761	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr3:134851761delC	uc003eqt.2	+	5	1387	c.1167delC	c.(1165-1167)TGCfs	p.C389fs	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	389	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGACGGAGTGCCGCGTCTCCA	0.617			NA											8	43	---	---	---	---	NA	NA	NA	NA	NA
DCAF4L2	138009	broad.mit.edu	37	8	88885535	88885536	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7574-01A-11D-2036-08	TCGA-55-7574-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61ff2f50-8ae1-4332-a96e-e5dc24213556	c5e5daaa-44dc-4055-91d9-36d4ab69a60f	g.chr8:88885535_88885536insA	uc003ydz.2	-	1	761_762	c.664_665insT	c.(664-666)GGGfs	p.G222fs		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	222										ovary(1)	1						ACTGCTAGTCCCAAATGACTGC	0.53			NA											8	131	---	---	---	---	NA	NA	NA	NA	NA
