Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHL17	339451	broad.mit.edu	37	1	897302	897302	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:897302G>T	uc001aca.1	+	4	693	c.586G>T	c.(586-588)GGT>TGT	p.G196C	NOC2L_uc001abz.3_5'Flank|NOC2L_uc009vjq.2_5'Flank|NOC2L_uc009vjr.1_5'Flank|KLHL17_uc001acb.1_Missense_Mutation_p.G72C|KLHL17_uc010nya.1_Missense_Mutation_p.G72C|KLHL17_uc001acc.1_5'Flank|KLHL17_uc010nyb.1_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	196	BACK.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAACTGCCTGGGTATCCGGGG	0.627			NA											5	45					0.000602214	0.000682885	0.000602	1	0
AGRN	375790	broad.mit.edu	37	1	979000	979000	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:979000G>A	uc001ack.1	+	9	1736	c.1686G>A	c.(1684-1686)TTG>TTA	p.L562L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	562	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GCGTGGCTTTGGCCCAGCCCG	0.682			NA											8	36					0	0	0.00308	0	0
TAS1R3	83756	broad.mit.edu	37	1	1268367	1268367	+	Nonsense_Mutation	SNP	G	G	T	rs143311630	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:1268367G>T	uc010nyk.1	+	4	1342	c.1342G>T	c.(1342-1344)GGA>TGA	p.G448*		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	448	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CGACAGCAGCGGAAACGTGGA	0.662			NA											5	21					0.000602214	0.000682885	0.000602	1	0
ACTRT2	140625	broad.mit.edu	37	1	2939307	2939307	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:2939307A>T	uc001ajz.2	+	1	1262	c.1057A>T	c.(1057-1059)AGC>TGC	p.S353C		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	353						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CTCTCTGAGTAGCTTCAAGCA	0.602			NA											26	91					0	0	0.005443	0	0
AJAP1	55966	broad.mit.edu	37	1	4772150	4772150	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:4772150G>T	uc001alm.1	+	2	601	c.220G>T	c.(220-222)GTC>TTC	p.V74F	AJAP1_uc001aln.2_Missense_Mutation_p.V74F	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	74	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GCCAGCGCGGGTCCCGGCCCC	0.622			NA											4	36					0.000602214	0.000682885	0.000602	1	0
CAMTA1	23261	broad.mit.edu	37	1	7737720	7737720	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:7737720G>T	uc001aoi.2	+	11	3048	c.2841G>T	c.(2839-2841)TCG>TCT	p.S947S	CAMTA1_uc010nzv.1_Silent_p.S34S|CAMTA1_uc001aok.3_5'Flank	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	947	IPT/TIG.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCTCCAACTCGGTGGTGTTTG	0.552			NA											15	72					6.31663e-08	9.21544e-08	0.003163	1	0
SLC45A1	50651	broad.mit.edu	37	1	8397904	8397904	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:8397904C>T	uc001apb.2	+	6	1626	c.1626C>T	c.(1624-1626)CTC>CTT	p.L542L	SLC45A1_uc001apc.2_Silent_p.L240L	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	542	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGTTGCTCTTCTACACAG	0.557			NA											13	90					0	0	0.003163	0	0
UBE4B	10277	broad.mit.edu	37	1	10207066	10207066	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:10207066G>T	uc001aqs.3	+	19	3222	c.2509G>T	c.(2509-2511)GAG>TAG	p.E837*	UBE4B_uc001aqr.3_Nonsense_Mutation_p.E708*|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Nonsense_Mutation_p.E292*|UBE4B_uc001aqt.1_Nonsense_Mutation_p.E177*	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	837					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CCTACTTGACGAGAGCTTCCT	0.527			NA											22	60					9.95505e-16	1.75905e-15	0.002299	1	0
MTOR	2475	broad.mit.edu	37	1	11264722	11264722	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:11264722C>A	uc001asd.2	-	26	3961	c.3840G>T	c.(3838-3840)TGG>TGT	p.W1280C		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1280					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GCCATTCCAGCCAGTCATCTT	0.582			NA											6	16					0.00307968	0.0033563	0.00308	1	0
PTCHD2	57540	broad.mit.edu	37	1	11579514	11579514	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:11579514C>A	uc001ash.3	+	8	2130	c.1992C>A	c.(1990-1992)CCC>CCA	p.P664P	PTCHD2_uc001asi.1_Silent_p.P664P	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	664	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCCCCATACCCTACCTGGATG	0.647			NA											23	117					7.01153e-11	1.13305e-10	0.007291	1	0
TNFRSF8	943	broad.mit.edu	37	1	12164553	12164553	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:12164553C>T	uc001atq.2	+	4	608	c.386C>T	c.(385-387)TCT>TTT	p.S129F	TNFRSF8_uc010obc.1_Missense_Mutation_p.S18F	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	129	TNFR-Cys 3.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTTCCATTCTGTCTGTCCG	0.577			NA											3	22					0	0	0.009096	0	0
LOC440563	440563	broad.mit.edu	37	1	13183308	13183308	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:13183308G>C	uc010obg.1	-	1	660	c.565C>G	c.(565-567)CAG>GAG	p.Q189E		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	189						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TGTTTTATCTGGGTCAACTCC	0.433			NA											29	367					0	0	0.003755	0	0
CTRC	11330	broad.mit.edu	37	1	15770036	15770036	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:15770036G>A	uc001awi.1	+	5	502	c.479G>A	c.(478-480)TGG>TAG	p.W160*	CTRC_uc001awj.1_Nonsense_Mutation_p.W160*	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	160	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTCACCGGCTGGGGCCGCCTC	0.587			NA											26	99					0	0	0.003954	0	0
IGSF21	84966	broad.mit.edu	37	1	18661461	18661461	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:18661461G>C	uc001bau.1	+	4	764	c.381G>C	c.(379-381)GAG>GAC	p.E127D		NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	127	Ig-like 1.					extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCACCAGGGAGAAGGTGGTCC	0.607			NA											4	23					0	0	0.009096	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808309	18808309	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:18808309G>T	uc001bax.2	+	1	886	c.834G>T	c.(832-834)GCG>GCT	p.A278A	KLHDC7A_uc009vpg.2_Silent_p.A60A	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	278						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGAAGGCGGAGGGGGTTG	0.592			NA											12	91					7.93312e-07	1.09071e-06	0.00245	1	0
TAS1R2	80834	broad.mit.edu	37	1	19166166	19166166	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:19166166A>G	uc001bba.1	-	6	2448	c.2447T>C	c.(2446-2448)CTC>CCC	p.L816P		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	816	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGGGTAGAAGAGGATCATGTA	0.607			NA											4	28					0	0	0.000602	0	0
UBR4	23352	broad.mit.edu	37	1	19486754	19486754	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:19486754G>C	uc001bbi.2	-	39	5432	c.5428C>G	c.(5428-5430)CTC>GTC	p.L1810V	UBR4_uc001bbm.1_Missense_Mutation_p.L1021V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1810					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCTAACACGAGAGGAGCGAAG	0.413			NA											4	21					0	0	0.009096	0	0
UBR4	23352	broad.mit.edu	37	1	19513693	19513693	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:19513693G>A	uc001bbi.2	-	13	1601	c.1597C>T	c.(1597-1599)CTG>TTG	p.L533L		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	533					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTCAAGAGCAGGTTCATCAGT	0.433			NA											8	32					0	0	0.00308	0	0
HTR6	3362	broad.mit.edu	37	1	19992446	19992446	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:19992446C>T	uc001bcl.2	+	1	667	c.200C>T	c.(199-201)TCG>TTG	p.S67L		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	67	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	TTCCTGGTGTCGCTCTTCACG	0.677	Esophageal Squamous(168;1879 2619 6848 21062)		NA											5	10					0	0	0.001168	0	0
HP1BP3	50809	broad.mit.edu	37	1	21071429	21071429	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:21071429T>A	uc001bdw.1	-	13	1663	c.1523A>T	c.(1522-1524)AAG>ATG	p.K508M	HP1BP3_uc001bdv.1_Missense_Mutation_p.K470M|HP1BP3_uc010odh.1_Missense_Mutation_p.K470M|HP1BP3_uc001bdy.1_Missense_Mutation_p.K508M|HP1BP3_uc010odf.1_Missense_Mutation_p.K167M|HP1BP3_uc010odg.1_Missense_Mutation_p.K356M	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	508	Lys-rich.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GGGTCTGGTCTTCTTGGCAGG	0.542			NA											12	54					0	0	0.000978	0	0
USP48	84196	broad.mit.edu	37	1	22078012	22078012	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:22078012C>A	uc001bfb.2	-	6	1000	c.762G>T	c.(760-762)TCG>TCT	p.S254S	USP48_uc010odq.1_Silent_p.S254S|USP48_uc009vqc.2_Silent_p.S254S|USP48_uc001bfc.2_Silent_p.S254S|USP48_uc001bfe.1_Silent_p.S254S|USP48_uc001bff.2_Silent_p.S254S	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	254					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TCAAAAATTCCGAGATACAAT	0.358			NA											17	99					1.02788e-11	1.6949e-11	0.00499	1	0
LDLRAD2	401944	broad.mit.edu	37	1	22142456	22142456	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:22142456C>G	uc001bfg.1	+	3	719	c.532C>G	c.(532-534)CGC>GGC	p.R178G		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	178	Extracellular (Potential).|LDL-receptor class A.					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		TGCCTACTTCCGCTGCCAGAA	0.627			NA											7	70					0	0	0.000978	0	0
RUNX3	864	broad.mit.edu	37	1	25229066	25229066	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:25229066G>C	uc001bjq.2	-	5	1206	c.795C>G	c.(793-795)GAC>GAG	p.D265E	RUNX3_uc010oen.1_Missense_Mutation_p.D212E|RUNX3_uc009vrj.2_Missense_Mutation_p.D279E|RUNX3_uc001bjr.2_Missense_Mutation_p.D279E|RUNX3_uc001bjs.2_RNA	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	265	Pro/Ser/Thr-rich.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GCATCCTGGGGTCTGGGAAGC	0.672			NA											20	44					0	0	0.008871	0	0
SEPN1	57190	broad.mit.edu	37	1	26140371	26140371	+	Splice_Site	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:26140371G>T	uc010oer.1	+	14	1443	c.1388_splice	c.e14-1	p.G463_splice	SEPN1_uc010oes.1_Splice_Site_p.G429_splice	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor							endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCTGAACAGGTTCAGGGCG	0.597			NA											18	53					5.35267e-07	7.46502e-07	0.007413	1	0
CNKSR1	10256	broad.mit.edu	37	1	26509049	26509049	+	Missense_Mutation	SNP	G	G	A	rs140239583	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:26509049G>A	uc001bln.3	+	6	656	c.598G>A	c.(598-600)GAG>AAG	p.E200K	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.E200K|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	200	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCGTGCTCGAGCAGGTGCA	0.632	NSCLC(180;1396 2109 28270 30756 34275)		NA											6	24					0	0	0.001984	0	0
PIGV	55650	broad.mit.edu	37	1	27120928	27120928	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:27120928C>T	uc001bmz.2	+	3	734	c.403C>T	c.(403-405)CAT>TAT	p.H135Y	PIGV_uc001bmy.2_Intron|PIGV_uc009vso.2_Missense_Mutation_p.H135Y|PIGV_uc010ofg.1_Intron|PIGV_uc001bna.2_Missense_Mutation_p.H135Y	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	135	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		AGTTGCACTTCATGACCTGGG	0.502			NA											4	51					0	0	0.009096	0	0
TSSK3	81629	broad.mit.edu	37	1	32829695	32829695	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:32829695C>T	uc001bvf.2	+	2	1086	c.645C>T	c.(643-645)ATC>ATT	p.I215I	uc001bve.1_5'Flank	NM_052841	NP_443073	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	215	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				ACACAGACATCCCCAAGATGC	0.567			NA											24	87					0	0	0.00333	0	0
RLF	6018	broad.mit.edu	37	1	40701547	40701547	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:40701547G>T	uc001cfc.3	+	8	1204	c.1173G>T	c.(1171-1173)AAG>AAT	p.K391N	RLF_uc001cfd.3_Missense_Mutation_p.K82N	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	391					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGGAAATGAAGGCATCAGTTT	0.403			NA											11	48					1.08611e-07	1.558e-07	0.000978	1	0
HIVEP3	59269	broad.mit.edu	37	1	42047512	42047512	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:42047512C>A	uc001cgz.3	-	4	4170	c.2957G>T	c.(2956-2958)CGA>CTA	p.R986L	HIVEP3_uc001cha.3_Missense_Mutation_p.R986L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	986	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCGCATCTCTCGGGCATGTGG	0.607			NA											15	52					1.3612e-06	1.85225e-06	0.003163	1	0
EBNA1BP2	10969	broad.mit.edu	37	1	43637772	43637772	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:43637772G>A	uc001cin.2	-	1	215	c.18C>T	c.(16-18)CTC>CTT	p.L6L	EBNA1BP2_uc001cio.2_Silent_p.L61L|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_5'Flank|EBNA1BP2_uc010ojx.1_Silent_p.L61L|EBNA1BP2_uc010ojy.1_5'Flank	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	6					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCGAATCCGAGAGCGGGGGAG	0.647			NA											5	20					0	0	0.000602	0	0
CYP4B1	1580	broad.mit.edu	37	1	47283692	47283692	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:47283692C>G	uc001cqm.3	+	10	1344	c.1260C>G	c.(1258-1260)CCC>CCG	p.P420P	CYP4B1_uc001cqn.3_Silent_p.P421P|CYP4B1_uc009vym.2_Silent_p.P406P|CYP4B1_uc010omk.1_Silent_p.P257P	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	420					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CTGTATGGCCCGACCCTGAGG	0.582			NA											25	109					0	0	0.00632	0	0
TAL1	6886	broad.mit.edu	37	1	47685674	47685674	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:47685674G>T	uc001cqx.2	-	4	1291	c.714C>A	c.(712-714)TTC>TTA	p.F238L	TAL1_uc009vyq.2_5'UTR|TAL1_uc001cqy.2_Missense_Mutation_p.F238L	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	238	Helix-loop-helix motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						GCTTGGCCAAGAAGTTGATAT	0.537			NA	T	TRD@|SIL	lymphoblastic leukemia/biphasic								6	35					8.12818e-05	9.82943e-05	0.001984	1	0
KTI12	112970	broad.mit.edu	37	1	52498521	52498521	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:52498521C>A	uc001ctj.1	-	1	952	c.913G>T	c.(913-915)GAG>TAG	p.E305*	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	305							ATP binding			central_nervous_system(2)	2						CGCAAGTGCTCTGTGGTACCA	0.547			NA											16	71					2.31682e-05	2.9206e-05	0.003163	1	0
C1orf175	374977	broad.mit.edu	37	1	55148376	55148376	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:55148376G>C	uc010ooe.1	+	14	2753	c.2429G>C	c.(2428-2430)TGT>TCT	p.C810S	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.C378S|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.C328S|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.C810S|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_Intron|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.C12S	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	810						integral to membrane	binding				0						AAGCCCAGCTGTGATGTCCGA	0.612			NA											19	64					0	0	0.007413	0	0
DHCR24	1718	broad.mit.edu	37	1	55319740	55319740	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:55319740C>G	uc001cyc.1	-	7	1317	c.1188G>C	c.(1186-1188)CAG>CAC	p.Q396H	DHCR24_uc010ooi.1_Missense_Mutation_p.Q39H|DHCR24_uc010ooj.1_Missense_Mutation_p.Q210H|DHCR24_uc010ook.1_Missense_Mutation_p.Q355H	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	396					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						TGTGCAGGGCCTGCTGCAGGC	0.622	Pancreas(39;516 1021 24601 30715 32780)		NA											4	12					0	0	0.009096	0	0
INADL	10207	broad.mit.edu	37	1	62293239	62293239	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:62293239C>G	uc001dab.2	+	16	2078	c.1964C>G	c.(1963-1965)TCT>TGT	p.S655C	INADL_uc009waf.1_Missense_Mutation_p.S655C|INADL_uc001daa.2_Missense_Mutation_p.S655C|INADL_uc001dad.3_Missense_Mutation_p.S352C|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	655					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ACTGAAACCTCTCTTCCTGAG	0.453			NA											15	64					0	0	0.00499	0	0
ROR1	4919	broad.mit.edu	37	1	64515413	64515413	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:64515413G>T	uc001dbj.2	+	3	613	c.214G>T	c.(214-216)GGC>TGC	p.G72C	ROR1_uc001dbi.3_Missense_Mutation_p.G72C	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	72	Ig-like C2-type.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						CACGTCTCTGGGCCAGACAGC	0.557			NA											16	68					1.3612e-06	1.85225e-06	0.003163	1	0
IL12RB2	3595	broad.mit.edu	37	1	67861345	67861345	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:67861345C>G	uc001ddu.2	+	16	2802	c.2162C>G	c.(2161-2163)CCC>CGC	p.P721R	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.P635R|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	721	Cytoplasmic (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						TTCAGACATCCCCCCTGCTCC	0.542			NA											5	22					0	0	0.001168	0	0
LRRC7	57554	broad.mit.edu	37	1	70541879	70541879	+	Missense_Mutation	SNP	G	G	T	rs143842567		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:70541879G>T	uc001dep.2	+	22	4266	c.4236G>T	c.(4234-4236)TTG>TTT	p.L1412F	LRRC7_uc009wbg.2_Missense_Mutation_p.L696F|LRRC7_uc001deq.2_Missense_Mutation_p.L606F	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1412						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AGTCACCATTGCCTATTCAGA	0.517			NA											11	55					9.70103e-10	1.52042e-09	0.008291	1	0
TNNI3K	51086	broad.mit.edu	37	1	74701175	74701175	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:74701175G>T	uc001dgf.1	+	1	91	c.40G>T	c.(40-42)GAT>TAT	p.D14Y	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	14						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						AACTTGTACTGGTAATTATTC	0.289			NA											7	64					5.18039e-06	6.82593e-06	0.00308	1	0
C1orf173	127254	broad.mit.edu	37	1	75037806	75037806	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:75037806C>G	uc001dgg.2	-	14	3807	c.3588G>C	c.(3586-3588)CTG>CTC	p.L1196L		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1196	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCCTGCTGGACAGCTCTTCTC	0.552			NA											14	126					0	0	0.003163	0	0
C1orf173	127254	broad.mit.edu	37	1	75072430	75072430	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:75072430G>T	uc001dgg.2	-	10	1563	c.1344C>A	c.(1342-1344)AAC>AAA	p.N448K	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.N242K	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	448	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CAGAGGTTTTGTTCTCCTTGA	0.408			NA											23	122					2.21704e-12	3.6976e-12	0.00278	1	0
TYW3	127253	broad.mit.edu	37	1	75229748	75229748	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:75229748A>T	uc001dgn.2	+	6	820	c.731A>T	c.(730-732)GAT>GTT	p.D244V	TYW3_uc010oqw.1_Missense_Mutation_p.D211V|TYW3_uc010oqx.1_Missense_Mutation_p.D160V|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	244					tRNA processing		methyltransferase activity			ovary(2)	2						GAAAATGATGATGATGATGAT	0.323			NA											6	70					0	0	0.001984	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	76779596	76779596	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:76779596A>T	uc001dhh.2	+	2	288	c.125A>T	c.(124-126)CAA>CTA	p.Q42L	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.Q42L|ST6GALNAC3_uc010orh.1_Intron	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	42	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						TGCTTTGGACAACCTGGTACA	0.448			NA											9	55					0	0	0.000978	0	0
LPHN2	23266	broad.mit.edu	37	1	82416772	82416772	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:82416772T>C	uc001dit.3	+	8	1744	c.1563T>C	c.(1561-1563)TGT>TGC	p.C521C	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.C521C|LPHN2_uc001div.2_Silent_p.C521C|LPHN2_uc009wcd.2_Silent_p.C521C|LPHN2_uc001diw.2_Silent_p.C92C	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	521	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTAGCAACTGTACCTCACACT	0.413			NA											9	67					0	0	0.004482	0	0
TTLL7	79739	broad.mit.edu	37	1	84394841	84394841	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:84394841C>A	uc001djc.2	-	10	1516	c.1120G>T	c.(1120-1122)GCG>TCG	p.A374S	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	374	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		AGCTTCAACGCATTTAGCAGC	0.338			NA											6	41					0.00116845	0.00130265	0.001168	1	0
LPAR3	23566	broad.mit.edu	37	1	85331308	85331308	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:85331308C>A	uc001dkl.2	-	1	535	c.496G>T	c.(496-498)GGC>TGC	p.G166C	LPAR3_uc009wcj.1_Missense_Mutation_p.G166C	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	166	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						CAATTCCAGCCCAGTGTGGGG	0.542			NA											24	105					1.42536e-11	2.34235e-11	0.004656	1	0
COL24A1	255631	broad.mit.edu	37	1	86591549	86591549	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:86591549C>A	uc001dlj.2	-	3	512	c.470G>T	c.(469-471)AGT>ATT	p.S157I	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.S157I	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	157	TSP N-terminal.|Laminin G-like.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATCATGAACACTGTAGTTGAA	0.343			NA											10	22					7.48243e-07	1.03265e-06	0.006214	1	0
GBP4	115361	broad.mit.edu	37	1	89655791	89655791	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:89655791C>T	uc001dnb.2	-	7	1243	c.1127G>A	c.(1126-1128)AGG>AAG	p.R376K		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	376						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		AATGGCTTCCCTCTCACAGGC	0.527			NA											4	34					0	0	0.009096	0	0
CDC7	8317	broad.mit.edu	37	1	91989846	91989846	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:91989846G>A	uc001doe.2	+	12	1744	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	CDC7_uc001dof.2_Missense_Mutation_p.E527K|CDC7_uc010osw.1_Missense_Mutation_p.E499K|CDC7_uc009wdc.2_Missense_Mutation_p.E527K|CDC7_uc009wdd.2_Missense_Mutation_p.E170K	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	527	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		ttgttttgatgagtataATAC	0.254			NA											19	108					0	0	0.008871	0	0
BTBD8	284697	broad.mit.edu	37	1	92554427	92554427	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:92554427G>C	uc001doo.2	+	2	589	c.322G>C	c.(322-324)GCT>CCT	p.A108P	BTBD8_uc010otc.1_RNA	NM_183242	NP_899065	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	108	BTB 1.					nucleus				ovary(1)	1		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		GAATGTTGAAGCTTTAGAATT	0.294			NA											11	25					0	0	0.008291	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94341979	94341979	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:94341979G>A	uc001dqf.2	-	2	1550	c.1512C>T	c.(1510-1512)TAC>TAT	p.Y504Y	DNTTIP2_uc010otm.1_RNA	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		CCTCTTCCAAGTAAAAATTTT	0.313			NA											4	11					0	0	0.009096	0	0
DPYD	1806	broad.mit.edu	37	1	97658654	97658654	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:97658654C>A	uc001drv.2	-	20	2730	c.2593G>T	c.(2593-2595)GTT>TTT	p.V865F		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	865					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ATACGTGGAACTGGTTTCCCT	0.433			NA											10	35					3.07112e-06	4.08734e-06	0.000978	1	0
DPYD	1806	broad.mit.edu	37	1	98015157	98015157	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:98015157C>T	uc001drv.2	-	12	1620	c.1483G>A	c.(1483-1485)GAT>AAT	p.D495N		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	495					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGCTTTCCATCATTCACCGAT	0.408			NA											16	61					0	0	0.004007	0	0
PALMD	54873	broad.mit.edu	37	1	100155280	100155280	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:100155280T>A	uc001dsg.2	+	7	1907	c.1464T>A	c.(1462-1464)GCT>GCA	p.A488A	PALMD_uc001dsf.2_Silent_p.A488A	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	488					regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		GATCAGAAGCTAGTCCTCATG	0.468			NA											8	29					0	0	0.00308	0	0
COL11A1	1301	broad.mit.edu	37	1	103348790	103348790	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:103348790C>A	uc001dul.2	-	64	5254	c.4936G>T	c.(4936-4938)GAG>TAG	p.E1646*	COL11A1_uc001duk.2_Nonsense_Mutation_p.E842*|COL11A1_uc001dum.2_Nonsense_Mutation_p.E1658*|COL11A1_uc001dun.2_Nonsense_Mutation_p.E1607*|COL11A1_uc009weh.2_Nonsense_Mutation_p.E1530*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1646	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATGCAAGTCTCACCACCAGAT	0.378			NA											13	53					5.50884e-06	7.18716e-06	0.001368	1	0
COL11A1	1301	broad.mit.edu	37	1	103444652	103444652	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:103444652A>T	uc001dul.2	-	33	2937	c.2619T>A	c.(2617-2619)GCT>GCA	p.A873A	COL11A1_uc001duk.2_Silent_p.A69A|COL11A1_uc001dum.2_Silent_p.A885A|COL11A1_uc001dun.2_Silent_p.A834A|COL11A1_uc009weh.2_Silent_p.A757A	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	873	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGTTTGCCAGCTACTCCCT	0.393			NA											4	23					0	0	0.000602	0	0
AMY1A	276	broad.mit.edu	37	1	104297234	104297234	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:104297234G>A	uc001duy.2	+	7	1206	c.992G>A	c.(991-993)TGG>TAG	p.W331*	AMY1A_uc001duz.2_Nonsense_Mutation_p.W331*	NM_001008221	NP_001008222	P04745	AMY1_HUMAN	salivary amylase alpha 1A precursor	331					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding|protein binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)		CTTACCTTCTGGGATGCTAGG	0.388	Pancreas(131;743 2392 43382 44986)		NA											33	271					0	0	0.002522	0	0
VAV3	10451	broad.mit.edu	37	1	108307697	108307697	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:108307697C>A	uc001dvk.1	-	9	975	c.921_splice	c.e9+1	p.E307_splice	VAV3_uc010ouw.1_Splice_Site_p.E307_splice|VAV3_uc001dvl.1_Splice_Site_p.E131_splice|VAV3_uc010oux.1_Splice_Site_p.E307_splice	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TAAATAGGCACCTCTAATTTC	0.338			NA											4	36					0.00909568	0.00969496	0.009096	1	0
KCNA10	3744	broad.mit.edu	37	1	111059903	111059903	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:111059903C>A	uc001dzt.1	-	1	1895	c.1507G>T	c.(1507-1509)GGC>TGC	p.G503C		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	503						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GTGGAACAGCCACCATTGGTC	0.363			NA											7	41					0.000157383	0.000187214	0.00308	1	0
ADORA3	140	broad.mit.edu	37	1	112042824	112042824	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:112042824A>G	uc001ebh.3	-	2	1472	c.705T>C	c.(703-705)GTT>GTC	p.V235V	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Intron	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	235	Helical; Name=6; (By similarity).				activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	ACAAGAAAAGAACCAGAAACA	0.433			NA											9	28					0	0	0.004482	0	0
IGSF3	3321	broad.mit.edu	37	1	117122231	117122231	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:117122231A>G	uc001egr.1	-	10	3822	c.3117T>C	c.(3115-3117)GAT>GAC	p.D1039D	IGSF3_uc001egq.1_Silent_p.D1059D	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	1039	Ig-like C2-type 8.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CAAAGACAGCATCTGGGCCCA	0.488			NA											5	17					0	0	0.000602	0	0
HSD3B2	3284	broad.mit.edu	37	1	119965140	119965140	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:119965140A>G	uc001ehs.2	+	3	1789	c.1016A>G	c.(1015-1017)TAT>TGT	p.Y339C	HSD3B2_uc001eht.2_Missense_Mutation_p.Y339C|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	339					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GATCTGGCGTATAAGCCACTC	0.512			NA											6	26					0	0	0.00308	0	0
NBPF9	400818	broad.mit.edu	37	1	144220792	144220792	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:144220792G>T	uc010oxr.1	+	19	2169	c.2165G>T	c.(2164-2166)AGC>ATC	p.S722I	NBPF9_uc010oxn.1_Missense_Mutation_p.S593I|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxt.1_Missense_Mutation_p.S510I|NBPF9_uc001ekg.1_Missense_Mutation_p.S22I|NBPF9_uc001ekk.1_Missense_Mutation_p.S266I|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Missense_Mutation_p.S22I|uc010oxz.1_Missense_Mutation_p.S510I	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	695	NBPF 5.					cytoplasm					0						TCCAGGCTCAGCAGGGAGCTG	0.458			NA											17	226					6.94344e-10	1.09058e-09	0.006122	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244			NA											4	102					0	0	0.009096	0	0
TCHH	7062	broad.mit.edu	37	1	152082419	152082419	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152082419G>C	uc001ezp.2	-	2	3274	c.3274C>G	c.(3274-3276)CAG>GAG	p.Q1092E	TCHH_uc009wne.1_Missense_Mutation_p.Q1092E	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1092	10 X 30 AA tandem repeats.|4-7.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCAGCAGctgctcttcctcc	0.174			NA											20	101					0	0	0.008871	0	0
HRNR	388697	broad.mit.edu	37	1	152188223	152188223	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152188223G>C	uc001ezt.1	-	3	5958	c.5882C>G	c.(5881-5883)TCT>TGT	p.S1961C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1961	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTAGCTGGAAGACTGCCCAGA	0.617			NA											15	745					0	0	0.007413	0	0
HRNR	388697	broad.mit.edu	37	1	152192704	152192704	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152192704G>T	uc001ezt.1	-	3	1477	c.1401C>A	c.(1399-1401)CAC>CAA	p.H467Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	467					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGACTCGTGGTGACCAAAGC	0.572			NA											31	155					6.00712e-18	1.09057e-17	0.002445	1	0
FLG	2312	broad.mit.edu	37	1	152279701	152279701	+	Nonsense_Mutation	SNP	G	G	T	rs121909626		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152279701G>T	uc001ezu.1	-	3	7697	c.7661C>A	c.(7660-7662)TCA>TAA	p.S2554*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2554	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGCCCCTCTGATTGTCCCTG	0.597			NA							Ichthyosis				34	210					8.73648e-17	1.56077e-16	0.004289	1	0
FLG2	388698	broad.mit.edu	37	1	152328896	152328896	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152328896G>C	uc001ezw.3	-	3	1439	c.1366C>G	c.(1366-1368)CAT>GAT	p.H456D	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	456	Filaggrin 2.|Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTAGACTCATGCTGGCCACAA	0.488			NA											33	106					0	0	0.002836	0	0
CRNN	49860	broad.mit.edu	37	1	152382557	152382557	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152382557C>T	uc001ezx.2	-	3	1075	c.1001G>A	c.(1000-1002)GGC>GAC	p.G334D		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	334	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTCCTGCCTTGACCGTG	0.592			NA											24	163					0	0	0.003954	0	0
LCE2A	353139	broad.mit.edu	37	1	152671565	152671565	+	Missense_Mutation	SNP	G	G	C	rs61812673		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:152671565G>C	uc001faj.2	+	2	239	c.188G>C	c.(187-189)GGG>GCG	p.G63A		NM_178428	NP_848515	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	63	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAGCTCTGGGGGTGGCGGC	0.682			NA											17	73					0	0	0.00499	0	0
CRTC2	200186	broad.mit.edu	37	1	153924738	153924738	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:153924738G>A	uc010ped.1	-	10	823	c.753C>T	c.(751-753)AAC>AAT	p.N251N	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_5'UTR	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	251					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ATGGAAAGATGCTAGGGGAAG	0.547			NA											15	23					0	0	0.00499	0	0
AQP10	89872	broad.mit.edu	37	1	154296832	154296832	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:154296832A>T	uc001feu.2	+	6	822	c.782A>T	c.(781-783)CAG>CTG	p.Q261L	AQP10_uc001fev.2_3'UTR|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	261	Extracellular (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCCACTTACCAGCTGTTGGTG	0.602			NA									OREG0013832	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	66					0	0	0.003163	0	0
KCNN3	3782	broad.mit.edu	37	1	154744567	154744567	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:154744567G>T	uc001ffp.2	-	3	1646	c.1332C>A	c.(1330-1332)AAC>AAA	p.N444K	KCNN3_uc001ffo.2_Missense_Mutation_p.N139K|KCNN3_uc009wox.1_Missense_Mutation_p.N444K	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	449						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GGGTGTTGAAGTTGATCTTGT	0.577			NA											12	53					5.50884e-06	7.18716e-06	0.001368	1	0
RHBG	57127	broad.mit.edu	37	1	156354617	156354617	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:156354617G>T	uc010pho.1	+	11	1395	c.1357G>T	c.(1357-1359)GAG>TAG	p.E453*	RHBG_uc001fos.2_3'UTR|RHBG_uc009wrz.2_3'UTR|RHBG_uc001for.2_3'UTR	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	Error:Variant_position_missing_in_Q9H310_after_alignment					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					GAGGGTGGAGGAGGCAGACAC	0.577			NA									OREG0013871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	16					3.59834e-05	4.49329e-05	0.001168	1	0
NES	10763	broad.mit.edu	37	1	156642662	156642662	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:156642662C>A	uc001fpq.2	-	4	1451	c.1318G>T	c.(1318-1320)GTC>TTC	p.V440F		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	440	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCAGGCAGGACGCTGGCAGGA	0.667			NA											9	59					1.58986e-06	2.14735e-06	0.008291	1	0
FCRL5	83416	broad.mit.edu	37	1	157497686	157497686	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:157497686C>A	uc001fqu.2	-	9	1840	c.1682_splice	c.e9-1	p.V561_splice	FCRL5_uc009wsm.2_Splice_Site_p.V561_splice|FCRL5_uc010phv.1_Splice_Site_p.V561_splice|FCRL5_uc010phw.1_Splice_Site_p.V476_splice	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5							integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GACACTGGAACTGAGAGAGAA	0.423			NA											12	56					0.000219431	0.000260597	0.00245	1	0
KIRREL	55243	broad.mit.edu	37	1	158064602	158064602	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158064602G>T	uc001frn.3	+	15	2370	c.1966G>T	c.(1966-1968)GGC>TGC	p.G656C	KIRREL_uc010pib.1_Missense_Mutation_p.G556C|KIRREL_uc009wsq.2_Missense_Mutation_p.G492C|KIRREL_uc001fro.3_Missense_Mutation_p.G470C|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	656	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CTATAGCCGGGGCCCTGCCTC	0.657			NA											17	29					3.32936e-07	4.67008e-07	0.006122	1	0
CD1D	912	broad.mit.edu	37	1	158152753	158152753	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158152753A>T	uc001frr.2	+	5	1192	c.693A>T	c.(691-693)CCA>CCT	p.P231P	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	231	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GATTCTACCCAAAGCCTGTAT	0.612			NA											13	94					0	0	0.001368	0	0
CD1C	911	broad.mit.edu	37	1	158261151	158261151	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158261151C>G	uc001fru.2	+	2	581	c.289C>G	c.(289-291)CGG>GGG	p.R97G	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	97	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					TGGATTAACTCGGGAGATTCA	0.368			NA											12	55					0	0	0.001368	0	0
CD1C	911	broad.mit.edu	37	1	158262139	158262139	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158262139G>A	uc001fru.2	+	3	886	c.594G>A	c.(592-594)ATG>ATA	p.M198I	CD1C_uc001frv.2_Missense_Mutation_p.M1I	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	198	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding	p.M198I(1)		ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					CAGGGAAGATGTATGTACACA	0.453			NA											49	265					0	0	0.00361	0	0
OR10T2	128360	broad.mit.edu	37	1	158368428	158368428	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158368428T>C	uc010pih.1	-	1	829	c.829A>G	c.(829-831)ACC>GCC	p.T277A		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					ACTGTGTAGGTCACTGCCACC	0.473			NA											7	28					0	0	0.00308	0	0
OR10R2	343406	broad.mit.edu	37	1	158450496	158450496	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158450496T>A	uc010pik.1	+	1	829	c.829T>A	c.(829-831)TTC>ATC	p.F277I	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	277	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					CTGTGCTTCCTTCATCTACCT	0.483			NA											6	48					0	0	0.001168	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576328	158576328	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158576328C>T	uc010pio.1	+	1	100	c.100C>T	c.(100-102)CTG>TTG	p.L34L		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					GTTCCTCTCTCTGTATCTAGT	0.502			NA											22	122					0	0	0.00278	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576605	158576605	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158576605T>C	uc010pio.1	+	1	377	c.377T>C	c.(376-378)ATC>ACC	p.I126T		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TATGTGGCCATCTGTGCTCCA	0.527			NA											15	82					0	0	0.003163	0	0
SPTA1	6708	broad.mit.edu	37	1	158613118	158613118	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158613118A>T	uc001fst.1	-	31	4635	c.4436T>A	c.(4435-4437)CTA>CAA	p.L1479Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1479	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGACCTGTCTAGTACACGTTG	0.458			NA											10	35					0	0	0.000978	0	0
SPTA1	6708	broad.mit.edu	37	1	158615169	158615169	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158615169G>C	uc001fst.1	-	29	4202	c.4003C>G	c.(4003-4005)CGT>GGT	p.R1335G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1335	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATGTCAGCACGGTGCTCCTGT	0.488			NA											5	43					0	0	0.001984	0	0
OR6K3	391114	broad.mit.edu	37	1	158687240	158687240	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158687240A>T	uc010pip.1	-	1	714	c.714T>A	c.(712-714)ACT>ACA	p.T238T		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TCAATATCACAGTGACAATTC	0.448			NA											16	42					0	0	0.003163	0	0
OR6K3	391114	broad.mit.edu	37	1	158687470	158687470	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158687470C>A	uc010pip.1	-	1	484	c.484G>T	c.(484-486)GCA>TCA	p.A162S		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CAGGAACCTGCAGAGAGTTGA	0.512			NA											19	68					8.00594e-06	1.04263e-05	0.007413	1	0
OR6N1	128372	broad.mit.edu	37	1	158736408	158736408	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158736408C>T	uc010piq.1	-	1	65	c.65G>A	c.(64-66)GGT>GAT	p.G22D		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AATCTGGACACCCTGGAGATG	0.502			NA											8	23					0	0	0.00308	0	0
MNDA	4332	broad.mit.edu	37	1	158813156	158813156	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158813156C>A	uc001fsz.1	+	3	553	c.353C>A	c.(352-354)GCA>GAA	p.A118E		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	118					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					GCACCCACCGCAAGAAACAAA	0.448			NA											8	20					1.12685e-05	1.44938e-05	0.004482	1	0
MNDA	4332	broad.mit.edu	37	1	158813815	158813815	+	Missense_Mutation	SNP	C	C	A	rs149728698		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158813815C>A	uc001fsz.1	+	4	673	c.473C>A	c.(472-474)CCC>CAC	p.P158H		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	158					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					CAGAGTAAGCCCCCAGGTCCC	0.463			NA											20	82					8.34094e-07	1.14354e-06	0.008871	1	0
MNDA	4332	broad.mit.edu	37	1	158815621	158815621	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158815621C>A	uc001fsz.1	+	5	1015	c.815C>A	c.(814-816)TCT>TAT	p.S272Y		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	272	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TCTGATTACTCTGAATGTAAA	0.338			NA											14	54					7.93312e-07	1.09071e-06	0.00245	1	0
OR10J3	441911	broad.mit.edu	37	1	159283942	159283942	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:159283942A>T	uc010piu.1	-	1	508	c.508T>A	c.(508-510)TGT>AGT	p.C170S		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					AAGGCATCACAGAATGGCAGG	0.502			NA											9	33					0	0	0.006214	0	0
CD244	51744	broad.mit.edu	37	1	160811393	160811393	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:160811393C>A	uc009wtq.2	-	2	538	c.360G>T	c.(358-360)ACG>ACT	p.T120T	CD244_uc001fxa.2_Silent_p.T120T|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Silent_p.T120T|CD244_uc010pjt.1_RNA	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	120	Extracellular (Potential).|Ig-like 1.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AAACCTGGAACGTGGCTGTCT	0.468			NA											12	20					6.40141e-05	7.85211e-05	0.000978	1	0
APOA2	336	broad.mit.edu	37	1	161192794	161192794	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:161192794C>G	uc001fzc.1	-	3	157	c.99G>C	c.(97-99)CTG>CTC	p.L33L	APOA2_uc001fzb.1_Intron	NM_001643	NP_001634	P02652	APOA2_HUMAN	apolipoprotein A-II preproprotein	33					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			ACTGAGAAACCAGGCTCTCCA	0.448			NA											9	72					0	0	0.006214	0	0
FCGR2A	2212	broad.mit.edu	37	1	161479613	161479613	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:161479613G>A	uc001gan.2	+	4	421	c.368G>A	c.(367-369)TGG>TAG	p.W123*	FCGR2A_uc001gam.2_Nonsense_Mutation_p.W122*|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	123	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTTTCAGAATGGCTGGTGCTC	0.468			NA											35	64					0	0	0.004289	0	0
FCGR2B	2213	broad.mit.edu	37	1	161641338	161641338	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:161641338C>A	uc001gaz.1	+	3	382	c.290C>A	c.(289-291)CCC>CAC	p.P97H	FCGR2B_uc009wum.1_Missense_Mutation_p.P97H|FCGR2B_uc001gay.1_Missense_Mutation_p.P96H|FCGR2B_uc001gba.1_Missense_Mutation_p.P96H|FCGR2B_uc001gbb.1_Missense_Mutation_p.P97H|FCGR2B_uc009wun.1_Missense_Mutation_p.P90H	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	97	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CACACGCAGCCCAGCTACAGG	0.577			NA	T	?	ALL								8	64					0.000157383	0.000187214	0.00308	1	0
ATF6	22926	broad.mit.edu	37	1	161736161	161736161	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:161736161C>T	uc001gbr.2	+	1	78	c.11C>T	c.(10-12)CCG>CTG	p.P4L	ATF6_uc001gbq.1_Missense_Mutation_p.P4L	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	4	Cytoplasmic (Potential).|Transcription activation.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			ATGGGGGAGCCGGCTGGGGTT	0.567			NA											9	30					0	0	0.000978	0	0
PBX1	5087	broad.mit.edu	37	1	164789339	164789339	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:164789339C>G	uc001gct.2	+	7	1286	c.1028C>G	c.(1027-1029)TCT>TGT	p.S343C	PBX1_uc010pku.1_Missense_Mutation_p.S343C|PBX1_uc010pkv.1_Missense_Mutation_p.S260C|PBX1_uc001gcs.2_Intron|PBX1_uc010pkw.1_Missense_Mutation_p.S233C	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	343					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						ATGTCAAACTCTGGAGATTTG	0.488			NA	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								5	54					0	0	0.000602	0	0
FAM78B	149297	broad.mit.edu	37	1	166039586	166039586	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:166039586C>G	uc001gdr.2	-	3	1268	c.678G>C	c.(676-678)ATG>ATC	p.M226I	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	226										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					GGATGGGTTCCATCCGGCTCA	0.627			NA											14	87					0	0	0.001855	0	0
DUSP27	92235	broad.mit.edu	37	1	167095342	167095342	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:167095342G>C	uc001geb.1	+	5	974	c.974G>C	c.(973-975)AGT>ACT	p.S325T		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	325					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGCCACCTGAGTGGCTCCTCC	0.657			NA											3	1					0	0	0.009096	0	0
ADCY10	55811	broad.mit.edu	37	1	167793718	167793718	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:167793718T>A	uc001ger.2	-	28	4346	c.4048A>T	c.(4048-4050)AGC>TGC	p.S1350C	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.S1258C|ADCY10_uc010plj.1_Missense_Mutation_p.S1197C	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1350					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AAATACCTGCTGTTCAGAAGG	0.493			NA											21	148					0	0	0.00333	0	0
SFT2D2	375035	broad.mit.edu	37	1	168206008	168206008	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:168206008G>T	uc001gfi.3	+	6	476	c.413G>T	c.(412-414)TGG>TTG	p.W138L	TBX19_uc001gfj.3_Intron	NM_199344	NP_955376	O95562	SFT2B_HUMAN	SFT2 domain containing 2	138	Helical; Name=4; (Potential).				protein transport|vesicle-mediated transport	integral to membrane				skin(1)	1	all_hematologic(923;0.215)					GCATTGACGTGGTAAGTAACC	0.393			NA											48	152					3.76525e-18	6.85275e-18	0.00361	1	0
F5	2153	broad.mit.edu	37	1	169510946	169510946	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:169510946G>T	uc001ggg.1	-	13	3527	c.3382C>A	c.(3382-3384)CAA>AAA	p.Q1128K		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1128	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GGGAATGTTTGATAGTGTTCC	0.483			NA											20	90					1.33834e-09	2.07964e-09	0.007413	1	0
SELE	6401	broad.mit.edu	37	1	169698749	169698749	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:169698749T>C	uc001ggm.3	-	6	938	c.781A>G	c.(781-783)AGC>GGC	p.S261G	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	261	Sushi 2.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					CATGGGAAGCTTCCAGGGTTT	0.448			NA											15	67					0	0	0.003163	0	0
GORAB	92344	broad.mit.edu	37	1	170501310	170501310	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:170501310G>A	uc001gha.2	+	1	48	c.21G>A	c.(19-21)TTG>TTA	p.L7L	GORAB_uc009wvw.2_Silent_p.L7L|GORAB_uc001ggz.3_Silent_p.L7L|GORAB_uc009wvx.2_5'UTR|GORAB_uc001ghb.2_5'UTR	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	7						Golgi apparatus|nucleus					0						CAGCAGTGTTGGCAGTCGCGG	0.657			NA											7	59					0	0	0.00308	0	0
BAT2L2	23215	broad.mit.edu	37	1	171560734	171560734	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:171560734G>T	uc010pmg.1	+	34	8468	c.8202G>T	c.(8200-8202)CAG>CAT	p.Q2734H	BAT2L2_uc010pmh.1_Missense_Mutation_p.Q1646H|BAT2L2_uc010pmi.1_Missense_Mutation_p.Q650H|BAT2L2_uc010pmj.1_Missense_Mutation_p.Q266H	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							protein C-terminus binding				0						AGGCAAAGCAGAGAGCAGAGG	0.413			NA											7	57					1.26484e-09	1.97386e-09	0.00308	1	0
TNR	7143	broad.mit.edu	37	1	175334200	175334200	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:175334200C>A	uc001gkp.1	-	10	2614	c.2533G>T	c.(2533-2535)GTG>TTG	p.V845L	TNR_uc009wwu.1_Missense_Mutation_p.V845L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	845	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TGGACAGCCACAAGGTTCACA	0.557			NA											8	71					0.000274275	0.000319476	0.004482	1	0
TNR	7143	broad.mit.edu	37	1	175372489	175372489	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:175372489G>C	uc001gkp.1	-	2	844	c.763C>G	c.(763-765)CCC>GCC	p.P255A	TNR_uc009wwu.1_Missense_Mutation_p.P255A|TNR_uc010pmz.1_Missense_Mutation_p.P255A	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	255	EGF-like 3.|Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CCAGTGTAGGGCTCTTCACAG	0.622			NA											4	45					0	0	0.001168	0	0
PAPPA2	60676	broad.mit.edu	37	1	176709266	176709266	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:176709266G>T	uc001gkz.2	+	14	5249	c.4085G>T	c.(4084-4086)CGC>CTC	p.R1362L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1362					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACATCCTCCCGCATTGGTCTT	0.507			NA											20	44					1.96292e-10	3.13036e-10	0.010504	1	0
SEC16B	89866	broad.mit.edu	37	1	177929539	177929539	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:177929539C>A	uc001gli.1	-	8	1027	c.937_splice	c.e8-1	p.V313_splice	SEC16B_uc001glk.1_Translation_Start_Site|SEC16B_uc001glh.1_Translation_Start_Site|SEC16B_uc009wwz.1_Intron|SEC16B_uc001glj.1_Splice_Site_p.V314_splice|SEC16B_uc001gll.3_Splice_Site_p.V314_splice	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2						protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						TAAGAATAACCTGGAATAAAA	0.453			NA											5	6					0.000602214	0.000682885	0.000602	1	0
TDRD5	163589	broad.mit.edu	37	1	179621306	179621306	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:179621306T>C	uc001gnf.1	+	13	2384	c.2134T>C	c.(2134-2136)TCA>CCA	p.S712P	TDRD5_uc010pnp.1_Missense_Mutation_p.S712P|TDRD5_uc001gnh.1_Missense_Mutation_p.S267P	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	712					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						AAGTCCACAGTCAAAAGAGAG	0.323			NA											8	43					0	0	0.004482	0	0
TDRD5	163589	broad.mit.edu	37	1	179659919	179659919	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:179659919A>G	uc001gnf.1	+	17	3037	c.2787A>G	c.(2785-2787)GTA>GTG	p.V929V	TDRD5_uc010pnp.1_Silent_p.V983V|TDRD5_uc001gnh.1_Silent_p.V484V	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	929					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						AAGAATCTGTAGACCAGCTGT	0.443			NA											22	37					0	0	0.010504	0	0
CEP350	9857	broad.mit.edu	37	1	179981084	179981084	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:179981084A>G	uc001gnt.2	+	9	1650	c.1267A>G	c.(1267-1269)ACA>GCA	p.T423A	CEP350_uc009wxl.2_Missense_Mutation_p.T422A|CEP350_uc001gnu.2_Missense_Mutation_p.T257A	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	423						centrosome|nucleus|spindle				ovary(4)	4						TCTTATAAGTACATCTTCTTG	0.353			NA											3	12					0	0	0.009096	0	0
IER5	51278	broad.mit.edu	37	1	181058930	181058930	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:181058930G>T	uc001got.3	+	1	1293	c.892G>T	c.(892-894)GGT>TGT	p.G298C		NM_016545	NP_057629	Q5VY09	IER5_HUMAN	immediate early response 5	298										pancreas(1)	1						AGAGGAGAGCGGTCCGGAAGC	0.627			NA											5	16					1.23904e-05	1.57558e-05	0.000602	1	0
CACNA1E	777	broad.mit.edu	37	1	181620524	181620524	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:181620524C>T	uc001gow.2	+	7	1167	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	CACNA1E_uc009wxr.2_Silent_p.L241L|CACNA1E_uc009wxs.2_Silent_p.L241L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	334	I.|Helical; Name=S6 of repeat I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCATCCCCCTCATCATCATTG	0.438			NA											12	73					0	0	0.000978	0	0
CACNA1E	777	broad.mit.edu	37	1	181680202	181680202	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:181680202G>C	uc001gow.2	+	8	1333	c.1168G>C	c.(1168-1170)GCA>CCA	p.A390P	CACNA1E_uc009wxs.2_Missense_Mutation_p.A297P	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	390	Cytoplasmic (Potential).|Binding to the beta subunit (By similarity).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GATAGACAAAGCAGGTAGGCC	0.607			NA											5	46					0	0	0.000602	0	0
RGL1	23179	broad.mit.edu	37	1	183895386	183895386	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:183895386G>T	uc001gqo.2	+	18	2424	c.2267G>T	c.(2266-2268)CGG>CTG	p.R756L	RGL1_uc001gqm.2_Missense_Mutation_p.R791L|RGL1_uc010pog.1_Missense_Mutation_p.R754L|RGL1_uc010poh.1_Missense_Mutation_p.R754L|RGL1_uc010poi.1_Missense_Mutation_p.R727L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	756					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ACAGCTAAACGGGGCTGCTGG	0.527			NA											12	49					2.68362e-12	4.45536e-12	0.001368	1	0
C1orf26	54823	broad.mit.edu	37	1	185143897	185143897	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:185143897G>T	uc001grg.3	+	5	732	c.618G>T	c.(616-618)TGG>TGT	p.W206C	C1orf26_uc001grh.3_Missense_Mutation_p.W206C	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	206											0						TAGAGAAATGGAAGAGAAATC	0.328			NA											27	72					3.28513e-13	5.54246e-13	0.003954	1	0
HMCN1	83872	broad.mit.edu	37	1	186084471	186084471	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:186084471G>T	uc001grq.1	+	75	11715	c.11486G>T	c.(11485-11487)GGG>GTG	p.G3829V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3829	Ig-like C2-type 37.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAGGCTACTGGGATACCAAAA	0.388			NA											13	83					0.00185496	0.00205542	0.001855	1	0
HMCN1	83872	broad.mit.edu	37	1	186113375	186113375	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:186113375A>T	uc001grq.1	+	90	14224	c.13995A>T	c.(13993-13995)ACA>ACT	p.T4665T	HMCN1_uc001grs.1_Silent_p.T234T	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4665	TSP type-1 3.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTACTCAGACAAGAGCAAGAC	0.478			NA											19	119					0	0	0.008871	0	0
TPR	7175	broad.mit.edu	37	1	186308841	186308841	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:186308841C>G	uc001grv.2	-	30	4381	c.4084G>C	c.(4084-4086)GAA>CAA	p.E1362Q		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1362	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GTATGAACTTCCTTTTCAGAA	0.318			NA	T	NTRK1	papillary thyroid								5	39					0	0	0.000602	0	0
RGS1	5996	broad.mit.edu	37	1	192544930	192544930	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:192544930C>T	uc001gsi.1	+	1	74	c.8C>T	c.(7-9)GCA>GTA	p.A3V	RGS1_uc010pou.1_Missense_Mutation_p.A3V	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	3					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				ACCATGCGCGCAGCAGCCATC	0.443			NA											14	35					0	0	0.003163	0	0
CFH	3075	broad.mit.edu	37	1	196711029	196711029	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:196711029G>T	uc001gtj.3	+	19	3221	c.2981G>T	c.(2980-2982)AGC>ATC	p.S994I		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	994	Sushi 17.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						AGTTTACCTAGCTTTGAAAAT	0.363			NA											11	42					3.86212e-05	4.78167e-05	0.008291	1	0
CFHR4	10877	broad.mit.edu	37	1	196881879	196881879	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:196881879C>G	uc001gto.2	+	3	335	c.266C>G	c.(265-267)TCA>TGA	p.S89*	CFHR4_uc009wyy.2_Nonsense_Mutation_p.S335*|CFHR4_uc001gtp.2_Nonsense_Mutation_p.S336*	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	89	Sushi 2.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GGAACATGCTCAAAATCAGAT	0.244			NA											3	30					0	0	0.009096	0	0
CFHR5	81494	broad.mit.edu	37	1	196965196	196965196	+	Missense_Mutation	SNP	T	T	A	rs143240067	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:196965196T>A	uc001gts.3	+	6	963	c.835T>A	c.(835-837)TAT>AAT	p.Y279N		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	279	Sushi 5.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						CGAGTACGGTTATGTTCAGCC	0.353			NA											18	108					0	0	0.007413	0	0
CFHR5	81494	broad.mit.edu	37	1	196967403	196967403	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:196967403C>T	uc001gts.3	+	7	1244	c.1116C>T	c.(1114-1116)AAC>AAT	p.N372N		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	372	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TCTGTATAAACGGGAAATGGA	0.308			NA											14	15					0	0	0.007413	0	0
F13B	2165	broad.mit.edu	37	1	197024886	197024886	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:197024886C>T	uc001gtt.1	-	8	1357	c.1313G>A	c.(1312-1314)CGT>CAT	p.R438H		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	438	Sushi 7.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTGTTCGCAACGAGATATTTT	0.413			NA											26	52					0	0	0.005443	0	0
ASPM	259266	broad.mit.edu	37	1	197069979	197069979	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:197069979G>A	uc001gtu.2	-	18	8659	c.8402C>T	c.(8401-8403)TCT>TTT	p.S2801F	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.S649F	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2801					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGCAAGGCCAGAAGCTTTATA	0.393			NA											17	109					0	0	0.006122	0	0
CRB1	23418	broad.mit.edu	37	1	197398720	197398720	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:197398720C>A	uc001gtz.2	+	8	2953	c.2818C>A	c.(2818-2820)CAG>AAG	p.Q940K	CRB1_uc010poz.1_Missense_Mutation_p.Q916K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.Q828K|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.Q421K|CRB1_uc001gub.1_Missense_Mutation_p.Q589K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	940	Extracellular (Potential).|EGF-like 14.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGCCCAGTGCCAGCCGGTGCT	0.507			NA											4	47					5.9392e-07	8.25141e-07	0.001168	1	0
CRB1	23418	broad.mit.edu	37	1	197404326	197404326	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:197404326A>C	uc001gtz.2	+	9	3468	c.3333A>C	c.(3331-3333)GAA>GAC	p.E1111D	CRB1_uc010poz.1_Missense_Mutation_p.E1087D|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.E999D|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.E592D|CRB1_uc001gub.1_Missense_Mutation_p.E760D	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1111	Extracellular (Potential).|Laminin G-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTTACTTTGAAAATGTTCATG	0.378			NA											13	78					0	0	0.001368	0	0
PTPRC	5788	broad.mit.edu	37	1	198668713	198668713	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:198668713C>A	uc001gur.1	+	5	493	c.313C>A	c.(313-315)CCT>ACT	p.P105T	PTPRC_uc001gus.1_Missense_Mutation_p.P105T|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.P41T|PTPRC_uc009wzf.1_Missense_Mutation_p.P41T|PTPRC_uc010ppg.1_Missense_Mutation_p.P41T|PTPRC_uc001guu.1_Missense_Mutation_p.P148T|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	105	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						AGTACAGACGCCTCACCTTCC	0.512			NA									OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	80					1.15088e-07	1.64282e-07	0.004007	1	0
NAV1	89796	broad.mit.edu	37	1	201779675	201779675	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:201779675G>T	uc001gwu.2	+	23	4924	c.4577G>T	c.(4576-4578)AGC>ATC	p.S1526I	NAV1_uc001gwx.2_Missense_Mutation_p.S1135I	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1529					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TGCGTCGACAGCCTGGTGTTC	0.577			NA											8	8					5.4927e-09	8.34799e-09	0.004482	1	0
LMOD1	25802	broad.mit.edu	37	1	201869655	201869655	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:201869655C>A	uc001gxb.2	-	2	734	c.486G>T	c.(484-486)CGG>CGT	p.R162R	LMOD1_uc010ppu.1_Silent_p.R111R	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	162					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						CAGCCCTGACCCGGCCCTTGT	0.318			NA											24	48					5.45024e-15	9.45834e-15	0.00333	1	0
LRRN2	10446	broad.mit.edu	37	1	204587709	204587709	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:204587709C>A	uc001hbe.1	-	3	1800	c.1412G>T	c.(1411-1413)GGC>GTC	p.G471V	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.G471V|LRRN2_uc009xbf.1_Missense_Mutation_p.G471V|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	471	Ig-like C2-type.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GTACCTCCTGCCTGCATGGGC	0.647			NA											5	35					0.000602214	0.000682885	0.000602	1	0
TRAF3IP3	80342	broad.mit.edu	37	1	209951493	209951493	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:209951493G>A	uc001hho.2	+	13	1517	c.1227G>A	c.(1225-1227)CTG>CTA	p.L409L	TRAF3IP3_uc001hhl.2_Silent_p.L389L|TRAF3IP3_uc001hhm.1_3'UTR|TRAF3IP3_uc001hhn.2_Silent_p.L389L|TRAF3IP3_uc009xcr.2_Silent_p.L409L	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	409	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		AACTCACCCTGGTGACCAGAG	0.458			NA											5	33					0	0	0.000602	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209951495	209951495	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:209951495T>A	uc001hho.2	+	13	1519	c.1229T>A	c.(1228-1230)GTG>GAG	p.V410E	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.V390E|TRAF3IP3_uc001hhm.1_3'UTR|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.V390E|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.V410E	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	410	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CTCACCCTGGTGACCAGAGTA	0.463			NA											5	34					0	0	0.000602	0	0
HHAT	55733	broad.mit.edu	37	1	210577832	210577832	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:210577832G>A	uc009xcx.2	+	6	659	c.493G>A	c.(493-495)GAG>AAG	p.E165K	HHAT_uc010psq.1_Intron|HHAT_uc001hhz.3_Missense_Mutation_p.E165K|HHAT_uc010psr.1_Missense_Mutation_p.E166K|HHAT_uc010pss.1_Missense_Mutation_p.E120K|HHAT_uc009xcy.2_Missense_Mutation_p.E100K|HHAT_uc010pst.1_Missense_Mutation_p.E102K|HHAT_uc010psu.1_Missense_Mutation_p.E100K	NM_001122834	NP_001116306	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	165					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		GACAGAAAACGAGTACTACCT	0.557			NA											7	33					0	0	0.001984	0	0
NSL1	25936	broad.mit.edu	37	1	212911978	212911978	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:212911978C>T	uc001hjn.2	-	6	652	c.618G>A	c.(616-618)AGG>AGA	p.R206R	NSL1_uc001hjm.2_3'UTR|NSL1_uc010pti.1_Silent_p.R165R	NM_015471	NP_056286	Q96IY1	NSL1_HUMAN	NSL1, MIND kinetochore complex component isoform	206					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		CAGGCTGCATCCTGAGAACTT	0.398			NA											19	72					0	0	0.010504	0	0
VASH2	79805	broad.mit.edu	37	1	213134569	213134569	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:213134569C>A	uc001hjy.2	+	2	542	c.338C>A	c.(337-339)GCG>GAG	p.A113E	VASH2_uc001hju.2_Missense_Mutation_p.A113E|VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.A48E|VASH2_uc010ptn.1_Missense_Mutation_p.A9E|VASH2_uc001hjw.2_Missense_Mutation_p.A113E	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	113					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		TGGCTCCAGGCGATCCAGAAT	0.522			NA											19	101					2.27731e-05	2.87577e-05	0.001882	1	0
RPS6KC1	26750	broad.mit.edu	37	1	213415049	213415049	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:213415049C>A	uc010ptr.1	+	11	2389	c.2230C>A	c.(2230-2232)CAT>AAT	p.H744N	RPS6KC1_uc001hkd.2_Missense_Mutation_p.H732N|RPS6KC1_uc010pts.1_Missense_Mutation_p.H532N|RPS6KC1_uc010ptt.1_Missense_Mutation_p.H532N|RPS6KC1_uc010ptu.1_Missense_Mutation_p.H563N|RPS6KC1_uc010ptv.1_Missense_Mutation_p.H279N|RPS6KC1_uc001hke.2_Missense_Mutation_p.H563N	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	744					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		ATGCCAAGCACATGAGGAGAA	0.408			NA											22	28					2.27731e-05	2.87577e-05	0.001882	1	0
USH2A	7399	broad.mit.edu	37	1	215956147	215956147	+	Silent	SNP	C	C	T	rs114719960	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:215956147C>T	uc001hku.1	-	53	10905	c.10518G>A	c.(10516-10518)ACG>ACA	p.T3506T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3506	Extracellular (Potential).|Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTTGGTCCACGTAGGGGGAC	0.403			NA								HNSCC(13;0.011)			10	58					0	0	0.008291	0	0
USH2A	7399	broad.mit.edu	37	1	215960131	215960131	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:215960131T>A	uc001hku.1	-	52	10655	c.10268A>T	c.(10267-10269)CAC>CTC	p.H3423L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3423	Fibronectin type-III 19.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGTGCAAATGTGGCTGGTAAA	0.468			NA								HNSCC(13;0.011)			5	48					0	0	0.000602	0	0
USH2A	7399	broad.mit.edu	37	1	216052364	216052364	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:216052364G>T	uc001hku.1	-	42	8687	c.8300C>A	c.(8299-8301)ACT>AAT	p.T2767N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2767	Fibronectin type-III 14.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTGGTTAAAGTGATGTGAGG	0.408			NA								HNSCC(13;0.011)			17	74					1.99824e-07	2.83847e-07	0.00499	1	0
USH2A	7399	broad.mit.edu	37	1	216420490	216420490	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:216420490C>T	uc001hku.1	-	13	2633	c.2246G>A	c.(2245-2247)TGT>TAT	p.C749Y	USH2A_uc001hkv.2_Missense_Mutation_p.C749Y	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	749	Laminin EGF-like 5.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATGGAGGTTACACTGGCAGGG	0.408			NA								HNSCC(13;0.011)			18	97					0	0	0.008871	0	0
GPATCH2	55105	broad.mit.edu	37	1	217783678	217783678	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:217783678C>A	uc001hlf.1	-	5	1179	c.1083G>T	c.(1081-1083)GGG>GGT	p.G361G	GPATCH2_uc001hlg.3_Silent_p.G361G	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	361						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		AAGTTGGAGTCCCTCCAGATT	0.343			NA											18	75					1.50039e-11	2.46287e-11	0.001882	1	0
IARS2	55699	broad.mit.edu	37	1	220269552	220269552	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:220269552G>T	uc001hmc.2	+	2	478	c.374G>T	c.(373-375)GGA>GTA	p.G125V		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	125	HIGH region (By similarity).				isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CCTCATGTTGGACATGCTTTA	0.308			NA											6	30					4.096e-09	6.2909e-09	0.001168	1	0
DUSP10	11221	broad.mit.edu	37	1	221875811	221875811	+	Missense_Mutation	SNP	G	G	T	rs61757363		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:221875811G>T	uc001hmy.1	-	4	1574	c.1392C>A	c.(1390-1392)AAC>AAA	p.N464K	DUSP10_uc001hmx.1_Missense_Mutation_p.N122K|DUSP10_uc001hmz.1_Missense_Mutation_p.N122K	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	464					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GTGTCACACCGTTGTTTAGGT	0.468			NA											18	155					1.45105e-14	2.50621e-14	0.006122	1	0
DUSP10	11221	broad.mit.edu	37	1	221912792	221912792	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:221912792C>A	uc001hmy.1	-	2	477	c.295G>T	c.(295-297)GCT>TCT	p.A99S	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	99					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GTGGTGCCAGCGGCAATGGCT	0.562			NA											11	23					7.03913e-09	1.06427e-08	0.001368	1	0
SUSD4	55061	broad.mit.edu	37	1	223400986	223400986	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:223400986G>T	uc001hnx.2	-	6	1645	c.1011C>A	c.(1009-1011)GTC>GTA	p.V337V	SUSD4_uc001hny.3_Silent_p.V337V|SUSD4_uc010puw.1_Silent_p.V177V	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	337	Helical; (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		TGGCCAGGATGACGAGCAGCA	0.582			NA											8	20					5.4927e-09	8.34799e-09	0.004482	1	0
NUP133	55746	broad.mit.edu	37	1	229613447	229613447	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:229613447C>T	uc001htn.2	-	13	1745	c.1653G>A	c.(1651-1653)TTG>TTA	p.L551L		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	551					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				AATCAGAATCCAAATCAGAGT	0.443			NA											4	34					0	0	0.009096	0	0
TAF5L	27097	broad.mit.edu	37	1	229738095	229738095	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:229738095A>T	uc001htq.2	-	4	985	c.819T>A	c.(817-819)ACT>ACA	p.T273T	TAF5L_uc001htr.2_Silent_p.T273T	NM_014409	NP_055224	O75529	TAF5L_HUMAN	PCAF associated factor 65 beta isoform a	273	WD 1.				histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				AGATTTCTGCAGTGTTCAACA	0.478			NA											20	36					0	0	0.010504	0	0
EXOC8	149371	broad.mit.edu	37	1	231473215	231473215	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:231473215C>G	uc001huq.2	-	1	364	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	C1orf124_uc001hur.2_5'Flank|C1orf124_uc001hus.2_5'Flank|C1orf124_uc001hut.2_5'Flank	NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	93					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				CTTTTCTGCTCGGTCAGCAAA	0.468			NA											6	33					0	0	0.001168	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232600887	232600887	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:232600887T>A	uc001hvg.2	-	7	2677	c.2519A>T	c.(2518-2520)AAG>ATG	p.K840M	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	840					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TGGCTTTACCTTCTCCTTTTT	0.507			NA											20	91					0	0	0.002299	0	0
LYST	1130	broad.mit.edu	37	1	235915417	235915417	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:235915417T>C	uc001hxj.2	-	27	7690	c.7515A>G	c.(7513-7515)ATA>ATG	p.I2505M	LYST_uc009xga.1_Missense_Mutation_p.I87M	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2505					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGTAACTGCTATGAAAAGTT	0.313			NA							Chediak-Higashsyndrome				6	34					0	0	0.001984	0	0
LYST	1130	broad.mit.edu	37	1	235973489	235973489	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:235973489G>A	uc001hxj.2	-	5	804	c.629C>T	c.(628-630)ACC>ATC	p.T210I	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.T210I	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	210					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTGTTCTTTGGTTGCTAAGCG	0.433			NA							Chediak-Higashsyndrome				31	126					0	0	0.002836	0	0
HEATR1	55127	broad.mit.edu	37	1	236754225	236754225	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:236754225C>G	uc001hyd.1	-	12	1577	c.1452G>C	c.(1450-1452)ATG>ATC	p.M484I		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	484					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TCAGGCTGAGCATCAAAGAAG	0.348			NA											6	19					0	0	0.001984	0	0
ZNF238	10472	broad.mit.edu	37	1	244217947	244217947	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:244217947G>A	uc001iae.2	+	1	1366	c.844G>A	c.(844-846)GAG>AAG	p.E282K	ZNF238_uc001iad.3_Missense_Mutation_p.E291K|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	282					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			TTCCTGTGATGAGAGTGATGT	0.468			NA											9	56					0	0	0.006214	0	0
NLRP3	114548	broad.mit.edu	37	1	247592911	247592911	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:247592911C>A	uc001icr.2	+	6	2319	c.2181C>A	c.(2179-2181)TCC>TCA	p.S727S	NLRP3_uc001ics.2_Silent_p.S727S|NLRP3_uc001icu.2_Silent_p.S727S|NLRP3_uc001icw.2_Intron|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Silent_p.S725S	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	727					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACCTCACTTCCAGTTTTTGCC	0.502			NA											18	122					5.03518e-11	8.19132e-11	0.007413	1	0
OR2G2	81470	broad.mit.edu	37	1	247751823	247751823	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:247751823G>T	uc010pyy.1	+	1	162	c.162G>T	c.(160-162)CTG>CTT	p.L54L		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTTCTCGTCTGGAACCCAAGC	0.428			NA											23	155					5.45024e-15	9.45834e-15	0.00333	1	0
OR2G2	81470	broad.mit.edu	37	1	247752093	247752093	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:247752093C>A	uc010pyy.1	+	1	432	c.432C>A	c.(430-432)TGC>TGA	p.C144*		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCCATCTCTGCATGGCCTTGG	0.572			NA											29	153					8.88839e-20	1.64024e-19	0.002096	1	0
OR2G2	81470	broad.mit.edu	37	1	247752523	247752523	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:247752523C>G	uc010pyy.1	+	1	862	c.862C>G	c.(862-864)CTT>GTT	p.L288V		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AACCCGCATGCTTAACCCTCT	0.348			NA											27	143					0	0	0.008361	0	0
OR2G3	81469	broad.mit.edu	37	1	247769067	247769067	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:247769067C>G	uc010pyz.1	+	1	180	c.180C>G	c.(178-180)TAC>TAG	p.Y60*		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CCCCAATGTACTTTTTTCTCA	0.423			NA											39	217					0	0	0.00623	0	0
OR2AK2	391191	broad.mit.edu	37	1	248128964	248128964	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248128964G>T	uc010pzd.1	+	1	331	c.331G>T	c.(331-333)GGC>TGC	p.G111C	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	111	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TAGATTTTTGGGCTGTGAGAT	0.478	Melanoma(45;390 1181 23848 28461 41504)		NA											27	147					2.65835e-16	4.73173e-16	0.007291	1	0
OR2L1P	26247	broad.mit.edu	37	1	248154134	248154134	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248154134A>T	uc001idv.1	+	1	566	c.322A>T	c.(322-324)ACG>TCG	p.T108S	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						CCTAGCCTGCACGGATACCTG	0.458			NA											13	76					0	0	0.003163	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285736	248285737	+	Missense_Mutation	DNP	AC	AC	TT			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248285736_248285737AC>TT	uc001idy.1	+	1	299_300	c.299_300AC>TT	c.(298-300)TAC>TTT	p.Y100F		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						TCCTTCTCCTACTGTGGGTCTC	0.416			NA											28	188					0	0	0.004672	0	0
OR2M5	127059	broad.mit.edu	37	1	248309381	248309381	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248309381G>T	uc010pze.1	+	1	932	c.932G>T	c.(931-933)GGA>GTA	p.G311V		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GGCAAGTGTGGAGAGTGAGTA	0.428			NA											6	40					0.00116845	0.00130265	0.001168	1	0
OR2M2	391194	broad.mit.edu	37	1	248343360	248343360	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248343360A>T	uc010pzf.1	+	1	73	c.73A>T	c.(73-75)ACG>TCG	p.T25S		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCCACCACACACGTTCCTCTT	0.498			NA											41	167					0	0	0.007835	0	0
OR2M2	391194	broad.mit.edu	37	1	248343446	248343446	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248343446C>G	uc010pzf.1	+	1	159	c.159C>G	c.(157-159)ACC>ACG	p.T53T		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACCTGGACACCCAGCTCCACA	0.537			NA											31	245					0	0	0.003271	0	0
OR2M4	26245	broad.mit.edu	37	1	248402423	248402423	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248402423C>T	uc010pzh.1	+	1	193	c.193C>T	c.(193-195)CAA>TAA	p.Q65*		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTCCTCAGTCAACTGTCCCT	0.478			NA											15	112					0	0	0.004007	0	0
OR2T6	254879	broad.mit.edu	37	1	248551230	248551230	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248551230T>C	uc001iei.1	+	1	321	c.321T>C	c.(319-321)TTT>TTC	p.F107F		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACATGGGCTTTATGGGGGCTG	0.557			NA											15	70					0	0	0.003163	0	0
OR2T1	26696	broad.mit.edu	37	1	248569919	248569919	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248569919C>A	uc010pzm.1	+	1	624	c.624C>A	c.(622-624)CTC>CTA	p.L208L		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	208	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGGCTTCCTCCTAACCCCCA	0.532			NA											9	53					1.12685e-05	1.44938e-05	0.004482	1	0
OR2T1	26696	broad.mit.edu	37	1	248570181	248570181	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248570181A>C	uc010pzm.1	+	1	886	c.886A>C	c.(886-888)ACT>CCT	p.T296P		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	296	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCCCACATGACTGTGGTGTC	0.517			NA											19	85					0	0	0.008871	0	0
OR2G6	391211	broad.mit.edu	37	1	248685080	248685080	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248685080C>A	uc001ien.1	+	1	133	c.133C>A	c.(133-135)CTC>ATC	p.L45I		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAACACTGCCCTCATACTAGT	0.468			NA											12	68					0.00136819	0.00152184	0.001368	1	0
OR2T11	127077	broad.mit.edu	37	1	248789791	248789791	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:248789791A>T	uc001ier.1	-	1	639	c.639T>A	c.(637-639)ACT>ACA	p.T213T		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGAGTAGGAAGTGGAGATGA	0.493			NA											8	41					0	0	0.004482	0	0
IL15RA	3601	broad.mit.edu	37	10	5995118	5995118	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:5995118C>T	uc001iiv.2	-	7	826	c.744G>A	c.(742-744)CCG>CCA	p.P248P	IL15RA_uc001iiu.2_Intron|IL15RA_uc010qau.1_Silent_p.P215P|IL15RA_uc001iiw.2_Silent_p.P212P|IL15RA_uc001iix.2_Silent_p.P179P|IL15RA_uc001iiy.2_Silent_p.P96P	NM_002189	NP_002180	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha isoform 1	248	Cytoplasmic (Potential).				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity				0						CCCAAGTCACCGGCAGAGCCT	0.557			NA											6	30					0	0	0.001168	0	0
ITIH5	80760	broad.mit.edu	37	10	7621752	7621752	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:7621752G>T	uc001ijq.2	-	9	1463	c.1384C>A	c.(1384-1386)CAC>AAC	p.H462N	ITIH5_uc001ijp.2_Missense_Mutation_p.H248N|ITIH5_uc001ijr.1_Missense_Mutation_p.H462N	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	462	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TCCTCCTCGTGCACGCGCCGT	0.612			NA											4	49					0.00024832	0.000292993	0.009096	1	0
ITIH5	80760	broad.mit.edu	37	10	7659155	7659155	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:7659155C>A	uc001ijq.2	-	6	822	c.743G>T	c.(742-744)AGG>ATG	p.R248M	ITIH5_uc001ijp.2_Missense_Mutation_p.R34M|ITIH5_uc001ijr.1_Missense_Mutation_p.R248M	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	248					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CTGGGCAATCCTGGCTTGTTG	0.403			NA											16	74					2.32078e-09	3.57952e-09	0.003163	1	0
GATA3	2625	broad.mit.edu	37	10	8100386	8100386	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:8100386G>T	uc001ika.2	+	3	917	c.360G>T	c.(358-360)ACG>ACT	p.T120T	GATA3_uc001ijz.2_Silent_p.T120T	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	120					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						TCTCCAAGACGTCCATCCACC	0.697			NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						10	76					4.68919e-08	6.87559e-08	0.008291	1	0
GATA3	2625	broad.mit.edu	37	10	8115980	8115980	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:8115980G>T	uc001ika.2	+	6	1883	c.1326G>T	c.(1324-1326)ATG>ATT	p.M442I	GATA3_uc001ijz.2_Missense_Mutation_p.M443I	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	442					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						TCACCGCCATGGGTTAGAGCC	0.607			NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						10	26					2.80697e-09	4.31569e-09	0.000978	1	0
CUBN	8029	broad.mit.edu	37	10	16955835	16955835	+	Missense_Mutation	SNP	G	G	A	rs140983139	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:16955835G>A	uc001ioo.2	-	48	7560	c.7508C>T	c.(7507-7509)CCG>CTG	p.P2503L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2503	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTGCAGGACGGATGCGTGGC	0.493			NA											29	67					0	0	0.003755	0	0
MRC1	4360	broad.mit.edu	37	10	18138603	18138603	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:18138603G>T	uc001ipm.2	+	7	1262	c.1159G>T	c.(1159-1161)GCT>TCT	p.A387S		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	387	Extracellular (Potential).|C-type lectin 2.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						CCAGAGGGATGCTCTGACCAC	0.478	GBM(115;1153 1594 28187 28781 35884)		NA											19	38					1.00905e-13	1.71632e-13	0.008871	1	0
SLC39A12	221074	broad.mit.edu	37	10	18270328	18270328	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:18270328C>A	uc001ipo.2	+	6	1285	c.1012C>A	c.(1012-1014)CCA>ACA	p.P338T	SLC39A12_uc001ipn.2_Missense_Mutation_p.P338T|SLC39A12_uc001ipp.2_Missense_Mutation_p.P338T|SLC39A12_uc010qck.1_Missense_Mutation_p.P204T	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	338	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GCAAATGAGTCCAGGGATCAT	0.502			NA											15	34					3.27435e-08	4.82536e-08	0.00245	1	0
SLC39A12	221074	broad.mit.edu	37	10	18280127	18280127	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:18280127T>A	uc001ipo.2	+	8	1590	c.1317T>A	c.(1315-1317)CAT>CAA	p.H439Q	SLC39A12_uc001ipn.2_Missense_Mutation_p.H439Q|SLC39A12_uc001ipp.2_Missense_Mutation_p.H439Q|SLC39A12_uc010qck.1_Missense_Mutation_p.H305Q	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	439	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GGCATTTCCATGAAAGCAAAG	0.358			NA											5	60					0	0	0.000602	0	0
SPAG6	9576	broad.mit.edu	37	10	22678165	22678165	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:22678165G>T	uc001iri.2	+	7	1071	c.929G>T	c.(928-930)CGG>CTG	p.R310L	SPAG6_uc001irj.2_Missense_Mutation_p.R310L|SPAG6_uc010qct.1_Missense_Mutation_p.R280L|SPAG6_uc009xkh.2_Missense_Mutation_p.R288L	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	310					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						GGGAACACACGGCTGCCTGGC	0.483			NA											9	35					1.12685e-05	1.44938e-05	0.004482	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24874021	24874021	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:24874021C>A	uc001isb.2	-	26	5684	c.5197G>T	c.(5197-5199)GTG>TTG	p.V1733L	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1732	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						ACATCAAACACTTTAGTTAAC	0.403			NA											22	117					5.45024e-15	9.45834e-15	0.00333	1	0
MYO3A	53904	broad.mit.edu	37	10	26310512	26310512	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:26310512G>T	uc001isn.2	+	8	1026	c.666G>T	c.(664-666)GAG>GAT	p.E222D	MYO3A_uc009xko.1_Missense_Mutation_p.E222D|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.E222D|MYO3A_uc001ism.2_Missense_Mutation_p.E222D	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	222	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CGGCCATTGAGCTGGGTGATG	0.483			NA											19	52					1.00905e-13	1.71632e-13	0.008871	1	0
MYO3A	53904	broad.mit.edu	37	10	26359099	26359099	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:26359099G>T	uc001isn.2	+	13	1590	c.1230G>T	c.(1228-1230)ATG>ATT	p.M410I	MYO3A_uc009xko.1_Missense_Mutation_p.M410I|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.M410I	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	410	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TTTTTGCAATGGCTGACTTAG	0.328			NA											8	40					5.18039e-06	6.82593e-06	0.00308	1	0
MYO3A	53904	broad.mit.edu	37	10	26457730	26457730	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:26457730A>T	uc001isn.2	+	28	3561	c.3201A>T	c.(3199-3201)AGA>AGT	p.R1067S	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1067	IQ 1.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CTTGTGTCAGAGCATTCTTGT	0.333			NA											6	49					0	0	0.001168	0	0
ANKRD26	22852	broad.mit.edu	37	10	27303640	27303640	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:27303640C>A	uc001ith.2	-	31	4676	c.4504G>T	c.(4504-4506)GCA>TCA	p.A1502S	ANKRD26_uc001itg.2_Missense_Mutation_p.A1189S|ANKRD26_uc009xku.1_Missense_Mutation_p.A1503S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1502						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GCTGCTTGTGCCTAAAACAAA	0.343			NA											8	18					0.00307968	0.0033563	0.00308	1	0
MTPAP	55149	broad.mit.edu	37	10	30611320	30611320	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:30611320C>A	uc001iva.3	-	6	1282	c.1219G>T	c.(1219-1221)GAT>TAT	p.D407Y	MTPAP_uc001ivb.3_Missense_Mutation_p.D537Y	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	407					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CTAGTCTTACCTGCTAGGGTT	0.343			NA											7	34					1.12685e-05	1.44938e-05	0.004482	1	0
HNRNPF	3185	broad.mit.edu	37	10	43882617	43882617	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:43882617C>A	uc009xmh.1	-	3	1203	c.716G>T	c.(715-717)GGC>GTC	p.G239V	HNRNPF_uc001jar.2_Missense_Mutation_p.G239V|HNRNPF_uc001jas.2_Missense_Mutation_p.G239V|HNRNPF_uc001jat.2_Missense_Mutation_p.G239V|HNRNPF_uc001jav.2_Missense_Mutation_p.G239V|HNRNPF_uc001jau.2_Missense_Mutation_p.G239V|uc010qfa.1_Missense_Mutation_p.A100D	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	239					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						GCCCCCGTAGCCTGTGCTGTA	0.617			NA											9	33					0.000274275	0.000319476	0.004482	1	0
SYT15	83849	broad.mit.edu	37	10	46962009	46962009	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:46962009C>T	uc001jea.2	-	8	1380	c.1227G>A	c.(1225-1227)GTG>GTA	p.V409V	SYT15_uc001jdz.2_Intron|SYT15_uc001jeb.2_Silent_p.V287V|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	409	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						GCCAGCGCTTCACCAGCTCCT	0.667	Ovarian(57;1152 1428 19651 37745)		NA											9	64					0	0	0.008291	0	0
PCDH15	65217	broad.mit.edu	37	10	55570360	55570360	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:55570360C>A	uc010qhs.1	-	36	4869	c.4474G>T	c.(4474-4476)GGT>TGT	p.G1492C	PCDH15_uc010qhq.1_Missense_Mutation_p.G1485C|PCDH15_uc010qhr.1_Missense_Mutation_p.G1480C|PCDH15_uc010qht.1_Missense_Mutation_p.G1485C|PCDH15_uc010qhu.1_Missense_Mutation_p.M1503I	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCACCTCACCATATTCCTCC	0.363			NA								HNSCC(58;0.16)			18	71					1.67942e-08	2.5105e-08	0.006122	1	0
PCDH15	65217	broad.mit.edu	37	10	56138669	56138669	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:56138669C>A	uc001jju.1	-	4	586	c.191G>T	c.(190-192)GGG>GTG	p.G64V	PCDH15_uc010qhq.1_Missense_Mutation_p.G69V|PCDH15_uc010qhr.1_Missense_Mutation_p.G64V|PCDH15_uc010qhs.1_Missense_Mutation_p.G69V|PCDH15_uc010qht.1_Missense_Mutation_p.G64V|PCDH15_uc010qhu.1_Missense_Mutation_p.G64V|PCDH15_uc001jjv.1_Missense_Mutation_p.G42V|PCDH15_uc010qhv.1_Missense_Mutation_p.G64V|PCDH15_uc010qhw.1_Missense_Mutation_p.G64V|PCDH15_uc010qhx.1_Missense_Mutation_p.G64V|PCDH15_uc010qhy.1_Missense_Mutation_p.G69V|PCDH15_uc010qhz.1_Missense_Mutation_p.G64V|PCDH15_uc010qia.1_Missense_Mutation_p.G42V|PCDH15_uc010qib.1_Missense_Mutation_p.G42V|PCDH15_uc001jjw.2_Missense_Mutation_p.G64V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	64	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCAGCAGTCCCTTTGATCAG	0.403			NA								HNSCC(58;0.16)			44	121					8.04919e-23	1.49676e-22	0.00361	1	0
BICC1	80114	broad.mit.edu	37	10	60558294	60558294	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:60558294C>T	uc001jki.1	+	11	1502	c.1502C>T	c.(1501-1503)CCA>CTA	p.P501L	BICC1_uc001jkj.1_Missense_Mutation_p.P142L	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	501					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TGGGCACCCCCACTTGCTAAT	0.403			NA											9	72					0	0	0.004482	0	0
ANK3	288	broad.mit.edu	37	10	61835269	61835269	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:61835269C>A	uc001jky.2	-	37	5562	c.5370G>T	c.(5368-5370)CAG>CAT	p.Q1790H	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1790	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTCTTAGAGACTGAAAAGCTG	0.453			NA											9	34					3.09899e-07	4.35533e-07	0.004482	1	0
ZNF365	22891	broad.mit.edu	37	10	64159473	64159473	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:64159473G>T	uc001jly.3	+	5	1256	c.1194G>T	c.(1192-1194)CTG>CTT	p.L398L	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Silent_p.L383L|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGGAGCTCCTGGGGTTTGGCC	0.532			NA											8	35					5.18039e-06	6.82593e-06	0.00308	1	0
DLG5	9231	broad.mit.edu	37	10	79593690	79593690	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:79593690C>G	uc001jzk.2	-	9	1800	c.1730G>C	c.(1729-1731)CGC>CCC	p.R577P	DLG5_uc001jzj.2_Missense_Mutation_p.R332P|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.R181P	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	577					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTTCAGCTCGCGGCTGACATC	0.657			NA											9	43					0	0	0.004482	0	0
POLR3A	11128	broad.mit.edu	37	10	79743987	79743987	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:79743987T>A	uc001jzn.2	-	25	3406	c.3312A>T	c.(3310-3312)AGA>AGT	p.R1104S		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1104					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TTTTCTCAATTCTCCCTTTCA	0.438			NA											9	71					0	0	0.006214	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143375	91143375	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:91143375C>G	uc001kgh.2	+	2	385	c.305C>G	c.(304-306)GCC>GGC	p.A102G	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	102	TPR 2.						binding				0						GGCAACTTTGCCTGGGTGTAT	0.478			NA											10	61					0	0	0.008291	0	0
KIF20B	9585	broad.mit.edu	37	10	91476254	91476254	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:91476254A>G	uc001kgs.1	+	9	1074	c.1002A>G	c.(1000-1002)ATA>ATG	p.I334M	KIF20B_uc001kgr.1_Missense_Mutation_p.I334M	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	334	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AACTAGGAATAAAGCACCAGA	0.308			NA											4	17					0	0	0.000602	0	0
KIF11	3832	broad.mit.edu	37	10	94389969	94389969	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:94389969G>A	uc001kic.2	+	12	1650	c.1342G>A	c.(1342-1344)GAC>AAC	p.D448N	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	448	Potential.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						AAATGAACTTGACCAGTGTAA	0.299	Colon(47;212 1003 2764 4062 8431)		NA											4	19					0	0	0.009096	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602702	96602702	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:96602702G>T	uc010qnz.1	+	7	1070	c.1070G>T	c.(1069-1071)AGA>ATA	p.R357I	CYP2C19_uc010qny.1_Missense_Mutation_p.R335I	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	357					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GAGGTCCAGAGATACATCGAC	0.537			NA											6	57					0.00198382	0.00217995	0.001984	1	0
CYP2C9	1559	broad.mit.edu	37	10	96748758	96748758	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:96748758C>T	uc001kka.3	+	9	1471	c.1446C>T	c.(1444-1446)TTC>TTT	p.F482F	CYP2C9_uc009xut.2_Silent_p.F480F	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	482					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGCCGCCCTTCTACCAGCTGT	0.498	Ovarian(54;1266 1406 16072 35076)		NA											11	70					0	0	0.000978	0	0
SORBS1	10580	broad.mit.edu	37	10	97174272	97174272	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:97174272G>A	uc001kkp.2	-	7	834	c.789C>T	c.(787-789)CTC>CTT	p.L263L	SORBS1_uc001kkl.2_5'UTR|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Silent_p.L263L|SORBS1_uc001kkq.2_Silent_p.L194L|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Silent_p.L231L|SORBS1_uc001kkw.2_Silent_p.L263L|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Silent_p.L461L|SORBS1_uc001kkx.1_Silent_p.L231L	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	263					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CAGCTCCCGTGAGGTCAGGCT	0.602			NA											6	27					0	0	0.001168	0	0
ABCC2	1244	broad.mit.edu	37	10	101594239	101594239	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:101594239C>A	uc001kqf.2	+	24	3500	c.3361C>A	c.(3361-3363)CCT>ACT	p.P1121T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1121	ABC transmembrane type-1 2.|Helical; Name=15; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CATGGCCACTCCTGTCTTCAC	0.463			NA											14	130					1.15088e-07	1.64282e-07	0.004007	1	0
PKD2L1	9033	broad.mit.edu	37	10	102055997	102055997	+	Missense_Mutation	SNP	C	C	T	rs145997401	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:102055997C>T	uc001kqx.1	-	7	1621	c.1238G>A	c.(1237-1239)CGG>CAG	p.R413Q	PKD2L1_uc009xwm.1_Missense_Mutation_p.R366Q	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	413	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CCCCATGAGCCGATTCACCTC	0.542			NA											10	31					0	0	0.006214	0	0
GBF1	8729	broad.mit.edu	37	10	104139301	104139301	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:104139301G>T	uc001kux.1	+	35	4906	c.4666G>T	c.(4666-4668)GCC>TCC	p.A1556S	GBF1_uc001kuy.1_Missense_Mutation_p.A1552S|GBF1_uc001kuz.1_Missense_Mutation_p.A1553S	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1556					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GTGCTGCGATGCCCGGCGCCA	0.562			NA											17	125					1.99824e-07	2.83847e-07	0.00499	1	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362061	105362061	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:105362061C>A	uc001kxj.1	-	14	2970	c.2830G>T	c.(2830-2832)GTG>TTG	p.V944L	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.V779L|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.V821L|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.V779L|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.V887L	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	972					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ACCTGCCGCACTCCGTTCCTC	0.652			NA											5	32					2.74318e-10	4.36034e-10	0.006214	1	0
ITPRIP	85450	broad.mit.edu	37	10	106074321	106074321	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:106074321C>T	uc001kye.2	-	2	1562	c.1489G>A	c.(1489-1491)GCC>ACC	p.A497T	ITPRIP_uc001kyf.2_Missense_Mutation_p.A497T|ITPRIP_uc001kyg.2_Missense_Mutation_p.A497T	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	497						plasma membrane					0						AGGGGCTCGGCCCTGAGCACG	0.592			NA											5	65					0	0	0.001984	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074328	106074328	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:106074328C>A	uc001kye.2	-	2	1555	c.1482G>T	c.(1480-1482)GTG>GTT	p.V494V	ITPRIP_uc001kyf.2_Silent_p.V494V|ITPRIP_uc001kyg.2_Silent_p.V494V	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	494						plasma membrane					0						CGGCCCTGAGCACGGCCTCAG	0.587			NA											13	51					1.3612e-06	1.85225e-06	0.003163	1	0
SORCS3	22986	broad.mit.edu	37	10	106959779	106959780	+	Missense_Mutation	DNP	CG	CG	TT	rs146574756		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:106959779_106959780CG>TT	uc001kyi.1	+	15	2259_2260	c.2032_2033CG>TT	c.(2032-2034)CGC>TTC	p.R678F	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	678	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTTCAGCCTCCGCTCCGAATGG	0.495	NSCLC(116;1497 1690 7108 13108 14106)		NA											8	58					0	0	0.004672	0	0
SORCS1	114815	broad.mit.edu	37	10	108366972	108366972	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:108366972A>G	uc001kym.2	-	23	3125	c.3117T>C	c.(3115-3117)TAT>TAC	p.Y1039Y	SORCS1_uc001kyl.2_Silent_p.Y1039Y|SORCS1_uc009xxs.2_Silent_p.Y1039Y|SORCS1_uc001kyn.1_Silent_p.Y1039Y|SORCS1_uc001kyo.2_Silent_p.Y1039Y	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1039	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTGGATCCTGATAGGGTAGGA	0.552			NA											7	50					0	0	0.004482	0	0
SORCS1	114815	broad.mit.edu	37	10	108923870	108923870	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:108923870C>A	uc001kym.2	-	1	423	c.415G>T	c.(415-417)GAG>TAG	p.E139*	SORCS1_uc001kyl.2_Nonsense_Mutation_p.E139*|SORCS1_uc009xxs.2_Nonsense_Mutation_p.E139*|SORCS1_uc001kyn.1_Nonsense_Mutation_p.E139*|SORCS1_uc001kyo.2_Nonsense_Mutation_p.E139*	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	139	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GTCCCAGGCTCCTGCTGCCCT	0.682			NA											7	38					5.68852e-11	9.22327e-11	0.004482	1	0
DCLRE1A	9937	broad.mit.edu	37	10	115602144	115602144	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:115602144C>A	uc001law.2	-	6	3541	c.2623G>T	c.(2623-2625)GTC>TTC	p.V875F		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	875					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTGCCACAGACAACAAGAGCA	0.388			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					12	80					6.40141e-05	7.85211e-05	0.000978	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118220556	118220556	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:118220556A>T	uc001lcl.3	+	6	745	c.644A>T	c.(643-645)GAC>GTC	p.D215V		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	215					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AACTTTGTTGACGTTATTCAT	0.443			NA											6	69					0	0	0.001168	0	0
PRLHR	2834	broad.mit.edu	37	10	120353854	120353854	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:120353854C>A	uc001ldp.1	-	2	1042	c.903G>T	c.(901-903)CGG>CGT	p.R301R		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	301	Extracellular (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GGTCGAGGTCCCGCAGCAGGT	0.662			NA											5	30					0.00116845	0.00130265	0.001168	1	0
NANOS1	340719	broad.mit.edu	37	10	120790054	120790054	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:120790054C>A	uc009xzf.1	+	1	827	c.741C>A	c.(739-741)TAC>TAA	p.Y247*		NM_199461	NP_955631	Q8WY41	NANO1_HUMAN	nanos homolog 1	247	Nanos-type.				epithelial cell migration	perinuclear region of cytoplasm	protein binding|RNA binding|translation repressor activity|zinc ion binding				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0193)		TGCGCCGCTACACGTGTCCCC	0.547			NA											8	22					3.09899e-07	4.35533e-07	0.004482	1	0
FGFR2	2263	broad.mit.edu	37	10	123274659	123274659	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:123274659T>A	uc010qtk.1	-	9	1906	c.1259A>T	c.(1258-1260)AAA>ATA	p.K420I	FGFR2_uc010qtg.1_Missense_Mutation_p.K308I|FGFR2_uc010qth.1_Missense_Mutation_p.K305I|FGFR2_uc010qti.1_Missense_Mutation_p.K331I|FGFR2_uc010qtj.1_Missense_Mutation_p.K421I|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Missense_Mutation_p.K305I|FGFR2_uc001lfl.3_Missense_Mutation_p.K421I|FGFR2_uc001lfm.2_Missense_Mutation_p.K332I|FGFR2_uc001lfn.3_RNA|FGFR2_uc001lfg.3_Missense_Mutation_p.K30I	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	420	Cytoplasmic (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GGGGATACGTTTGGTCAGCTT	0.498			5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				14	75					0	0	0.007413	0	0
TACC2	10579	broad.mit.edu	37	10	123843657	123843657	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:123843657G>T	uc001lfv.2	+	4	2002	c.1642G>T	c.(1642-1644)GGG>TGG	p.G548W	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.G548W|TACC2_uc010qtv.1_Missense_Mutation_p.G548W	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	548	Pro-rich.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGGCCACCGGGGCCAACGGA	0.597			NA											14	41					2.61681e-11	4.27139e-11	0.00245	1	0
CYP2E1	1571	broad.mit.edu	37	10	135346316	135346316	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:135346316C>G	uc001lnj.1	+	5	802	c.769C>G	c.(769-771)CTG>GTG	p.L257V	CYP2E1_uc001lnk.1_Missense_Mutation_p.L120V|CYP2E1_uc009ybl.1_Missense_Mutation_p.L58V|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Missense_Mutation_p.L58V	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	257					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CCATCAATCTCTGGACCCCAA	0.537			NA							Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				11	58					0	0	0.000978	0	0
SYCE1	93426	broad.mit.edu	37	10	135369516	135369516	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:135369516C>T	uc001lno.2	-	9	669	c.564G>A	c.(562-564)CTG>CTA	p.L188L	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Silent_p.L60L|SYCE1_uc009ybn.2_Silent_p.L188L|SYCE1_uc001lnn.2_Silent_p.L152L	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	188	Potential.				cell division	central element		p.T188N(1)		ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TGCTGCTGTCCAGGGCACAAA	0.567			NA											12	101					0	0	0.001368	0	0
CDKN1C	1028	broad.mit.edu	37	11	2905952	2905952	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:2905952G>A	uc001lws.3	-	1	1044	c.768C>T	c.(766-768)GCC>GCT	p.A256A	CDKN1C_uc001lwu.3_Silent_p.A245A|CDKN1C_uc009ydr.2_Silent_p.A245A|CDKN1C_uc001lwt.3_Intron|CDKN1C_uc001lwr.3_Silent_p.A256A	NM_000076	NP_000067	P49918	CDN1C_HUMAN	cyclin-dependent kinase inhibitor 1C isoform a	256					cell cycle arrest|G1 phase of mitotic cell cycle|negative regulation of epithelial cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding			central_nervous_system(1)	1		all_epithelial(84;0.000187)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|Breast(177;0.00328)|all_neural(188;0.00681)|all_lung(207;0.157)|Lung NSC(207;0.216)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCGCTGGCGGCCGCGGTGC	0.577	GBM(111;59 1151 2497 5746 16112 18241 29216)		NA							Beckwith-Wiedemann_syndrome				5	6					0	0	0.001984	0	0
OR51L1	119682	broad.mit.edu	37	11	5021140	5021140	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:5021140G>C	uc010qyu.1	+	1	928	c.928G>C	c.(928-930)GTC>CTC	p.V310L		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCACAAGTTTGTCCTAAGGAG	0.408			NA											17	33					0	0	0.00499	0	0
OR52J3	119679	broad.mit.edu	37	11	5067999	5067999	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:5067999C>T	uc010qyv.1	+	1	244	c.244C>T	c.(244-246)CGC>TGC	p.R82C		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCTGTGCCTCGCATGCTGGG	0.498			NA											13	15					0	0	0.00245	0	0
OR52L1	338751	broad.mit.edu	37	11	6008099	6008099	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:6008099G>C	uc001mcd.2	-	1	117	c.62C>G	c.(61-63)TCA>TGA	p.S21*		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCCAGCTTGAATTGCTAAG	0.453	Melanoma(121;653 1666 10547 22796 51255)		NA											7	21					0	0	0.001984	0	0
TRIM3	10612	broad.mit.edu	37	11	6472661	6472661	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:6472661G>C	uc001mdh.2	-	9	1928	c.1541C>G	c.(1540-1542)TCC>TGC	p.S514C	TRIM3_uc001mdi.2_Missense_Mutation_p.S514C|TRIM3_uc010raj.1_Missense_Mutation_p.S395C|TRIM3_uc009yfd.2_Missense_Mutation_p.S514C|TRIM3_uc010rak.1_Missense_Mutation_p.S514C	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	514	NHL 1.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCCTCATTGGAGAAAACCTG	0.607	Melanoma(6;5 510 1540 25169 29084)		NA											10	34					0	0	0.008291	0	0
OR10A4	283297	broad.mit.edu	37	11	6898719	6898719	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:6898719G>T	uc010rat.1	+	1	841	c.841G>T	c.(841-843)GTG>TTG	p.V281L		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTCTTCCACAGTGGTGACTCC	0.512			NA											10	42					7.03913e-09	1.06427e-08	0.001368	1	0
ZNF215	7762	broad.mit.edu	37	11	6953714	6953714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:6953714G>T	uc001mey.2	+	3	799	c.211G>T	c.(211-213)GAG>TAG	p.E71*	ZNF215_uc010raw.1_Nonsense_Mutation_p.E71*|ZNF215_uc010rax.1_5'UTR|ZNF215_uc001mez.1_Nonsense_Mutation_p.E71*	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	71	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CCAACTCTGGGAGCTCTGTCT	0.478			NA											7	36					8.12818e-05	9.82943e-05	0.001984	1	0
ZNF215	7762	broad.mit.edu	37	11	6962865	6962865	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:6962865C>G	uc001mey.2	+	4	1052	c.464C>G	c.(463-465)TCA>TGA	p.S155*	ZNF215_uc010raw.1_Nonsense_Mutation_p.S155*|ZNF215_uc010rax.1_5'UTR|ZNF215_uc001mez.1_Nonsense_Mutation_p.S155*	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	155					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		AAAGCTGGCTCACGAACAGGC	0.408			NA											6	23					0	0	0.001168	0	0
OR5P3	120066	broad.mit.edu	37	11	7847327	7847327	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:7847327G>A	uc010rbg.1	-	1	193	c.193C>T	c.(193-195)CAT>TAT	p.H65Y		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAGGCCAAATGGCAGAGGAAA	0.413			NA											8	37					0	0	0.00308	0	0
NLRP10	338322	broad.mit.edu	37	11	7981665	7981665	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:7981665C>G	uc001mfv.1	-	2	1511	c.1494G>C	c.(1492-1494)CTG>CTC	p.L498L		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	498							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTACCTCCAGCAGCCTTTGCA	0.502			NA											12	47					0	0	0.00245	0	0
CSNK2A1P	283106	broad.mit.edu	37	11	11373750	11373750	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:11373750C>G	uc001mjp.2	-	1	1155	c.917G>C	c.(916-918)CGA>CCA	p.R306P	GALNTL4_uc001mjo.2_Intron	NM_177559	NP_808227			casein kinase II alpha 1 subunit isoform a												0						GTGGTCATATCGCAGCAGTTT	0.522			NA											10	27					0	0	0.006214	0	0
BTBD10	84280	broad.mit.edu	37	11	13427269	13427269	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:13427269C>T	uc001mkz.2	-	7	1200	c.943G>A	c.(943-945)GAT>AAT	p.D315N	BTBD10_uc010rcl.1_Missense_Mutation_p.D323N|BTBD10_uc001mla.2_Missense_Mutation_p.D299N|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.D267N|BTBD10_uc010rcn.1_Missense_Mutation_p.D284N|BTBD10_uc009ygo.2_Missense_Mutation_p.D267N	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	315						nucleus					0				Epithelial(150;0.0214)		ACATCATCATCTGTAAGCACC	0.428			NA											21	81					0	0	0.002299	0	0
INSC	387755	broad.mit.edu	37	11	15260577	15260577	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:15260577C>T	uc001mly.2	+	11	1537	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L	INSC_uc001mlz.2_Silent_p.L450L|INSC_uc001mma.2_Silent_p.L450L|INSC_uc010rcs.1_Silent_p.L485L|INSC_uc001mmb.2_Silent_p.L450L|INSC_uc001mmc.2_Silent_p.L408L	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	497					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGGCTCGTCTCAGCCGAGACC	0.617			NA											7	19					0	0	0.001984	0	0
MUC15	143662	broad.mit.edu	37	11	26586719	26586719	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:26586719G>T	uc001mqx.2	-	2	953	c.687C>A	c.(685-687)CCC>CCA	p.P229P	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Silent_p.P256P|MUC15_uc001mqy.2_Silent_p.P256P	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	229	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TACCTTTTTGGGGATCTGACG	0.338			NA											9	42					0.000274275	0.000319476	0.004482	1	0
WT1	7490	broad.mit.edu	37	11	32413565	32413565	+	Missense_Mutation	SNP	C	C	A	rs121907903		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:32413565C>A	uc001mtn.1	-	9	1581	c.1385G>T	c.(1384-1386)CGG>CTG	p.R462L	WT1_uc001mtl.1_Missense_Mutation_p.R250L|WT1_uc001mtm.1_Missense_Mutation_p.R233L|WT1_uc001mto.1_Missense_Mutation_p.R462L|WT1_uc001mtp.1_Missense_Mutation_p.R445L|WT1_uc001mtq.1_Missense_Mutation_p.R445L|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	394	C2H2-type 3.|Important for interaction with target DNA.		R -> L (in WT1).|R -> P (in DDS).|R -> Q (in DDS).|R -> W (in DDS, WT1 and MEACHS).	R->A,S: Strongly reduced binding of DNA and RNA.	adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.R394P(6)|p.R394Q(4)|p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GTGGTCGGACCGGGAGAACTT	0.433			NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				24	79					6.12954e-19	1.12118e-18	0.004656	1	0
OR4C13	283092	broad.mit.edu	37	11	49974659	49974659	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:49974659G>C	uc010rhz.1	+	1	685	c.685G>C	c.(685-687)GAG>CAG	p.E229Q		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CCACAGCTTAGAGGCAAGGCA	0.483			NA											25	90					0	0	0.003954	0	0
OR4A16	81327	broad.mit.edu	37	11	55111467	55111467	+	Missense_Mutation	SNP	C	C	A	rs138375517		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55111467C>A	uc010rie.1	+	1	791	c.791C>A	c.(790-792)CCC>CAC	p.P264H		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TCCAACTTTCCCTTTGATAAA	0.368			NA											11	46					4.68919e-08	6.87559e-08	0.008291	1	0
OR4C16	219428	broad.mit.edu	37	11	55339944	55339944	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55339944T>A	uc010rih.1	+	1	341	c.341T>A	c.(340-342)ATC>AAC	p.I114N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TTCATCCTCATCCTCACGGCT	0.507			NA											12	96					0	0	0.001855	0	0
OR4S2	219431	broad.mit.edu	37	11	55418981	55418981	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55418981G>T	uc001nhs.1	+	1	602	c.602G>T	c.(601-603)AGT>ATT	p.S201I		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				ACAGCCAACAGTGGTACCATT	0.463			NA											31	44					1.13719e-10	1.82956e-10	0.008361	1	0
OR4C6	219432	broad.mit.edu	37	11	55433423	55433423	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55433423G>C	uc001nht.3	+	3	1046	c.781G>C	c.(781-783)GTC>CTC	p.V261L	OR4C6_uc010rik.1_Missense_Mutation_p.V261L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GAGGCCTGTGGTCACTCACCC	0.488			NA											14	73					0	0	0.001855	0	0
OR5L1	219437	broad.mit.edu	37	11	55579049	55579049	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55579049G>A	uc001nhw.1	+	1	107	c.107G>A	c.(106-108)GGA>GAA	p.G36E		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CTCATCTATGGAGTCACGTTG	0.502			NA											33	153					0	0	0.004289	0	0
OR5I1	10798	broad.mit.edu	37	11	55703324	55703324	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55703324G>C	uc010ris.1	-	1	553	c.553C>G	c.(553-555)CCC>GCC	p.P185A		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTAAGCAGGGGAGGGAGGTCA	0.403			NA											5	25					0	0	0.001168	0	0
OR5F1	338674	broad.mit.edu	37	11	55761413	55761413	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55761413G>T	uc010riv.1	-	1	689	c.689C>A	c.(688-690)TCG>TAG	p.S230*		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CCCCTCCCCCGAATGCATAGA	0.478			NA											8	20					5.18039e-06	6.82593e-06	0.00308	1	0
OR8H2	390151	broad.mit.edu	37	11	55872935	55872935	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55872935G>C	uc010riy.1	+	1	417	c.417G>C	c.(415-417)AGG>AGC	p.R139S		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TGTCCAAAAGGCTCTGCCTCG	0.468			NA								HNSCC(53;0.14)			6	191					0	0	0.006214	0	0
OR8H3	390152	broad.mit.edu	37	11	55890265	55890265	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55890265G>C	uc001nii.1	+	1	417	c.417G>C	c.(415-417)AGG>AGC	p.R139S		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TGCCCAAAAGGCTCTGCCTCG	0.458			NA											20	96					0	0	0.005443	0	0
OR5J2	282775	broad.mit.edu	37	11	55944482	55944482	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:55944482T>A	uc010rjb.1	+	1	389	c.389T>A	c.(388-390)TTG>TAG	p.L130*		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GTGAGTCCCTTGCTTTACACT	0.453			NA											13	62					0	0	0.001368	0	0
OR5T2	219464	broad.mit.edu	37	11	56000334	56000334	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:56000334C>T	uc010rjc.1	-	1	328	c.328G>A	c.(328-330)GCC>ACC	p.A110T		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	110	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAATAGCAGGCATCCACAGAA	0.393			NA											6	35					0	0	0.001168	0	0
OR8K3	219473	broad.mit.edu	37	11	56086209	56086209	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:56086209G>T	uc010rjf.1	+	1	427	c.427G>T	c.(427-429)GTG>TTG	p.V143L		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GGTATGTCAGGTGCTGGTAGC	0.413			NA											15	65					1.52009e-12	2.5469e-12	0.003163	1	0
OR5R1	219479	broad.mit.edu	37	11	56185388	56185388	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:56185388G>A	uc010rji.1	-	1	321	c.321C>T	c.(319-321)TTC>TTT	p.F107F		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CAGTGATCATGAAGGTGAGAA	0.458			NA											6	25					0	0	0.001168	0	0
OR9G4	283189	broad.mit.edu	37	11	56510984	56510984	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:56510984A>T	uc010rjo.1	-	1	304	c.304T>A	c.(304-306)TCA>ACA	p.S102T		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	102	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TTATCTTCTGAGACACAACTG	0.453			NA											20	70					0	0	0.008871	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57077513	57077513	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:57077513C>A	uc001njr.2	-	5	2984	c.2672G>T	c.(2671-2673)AGA>ATA	p.R891I	TNKS1BP1_uc001njs.2_Missense_Mutation_p.R891I|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.R342I	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	891	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CAGAGAATCTCTCTTCCCAAA	0.537			NA											16	115					5.3912e-06	7.08447e-06	0.006122	1	0
SERPING1	710	broad.mit.edu	37	11	57367360	57367360	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:57367360C>A	uc001nkp.1	+	3	251	c.60C>A	c.(58-60)GCC>GCA	p.A20A	SERPING1_uc001nkq.1_Silent_p.A20A|SERPING1_uc010rju.1_5'UTR|SERPING1_uc010rjv.1_Silent_p.A25A|SERPING1_uc001nkr.1_Silent_p.A20A|SERPING1_uc009ymi.1_Silent_p.A20A|SERPING1_uc009ymj.1_Silent_p.A20A|SERPING1_uc001nks.1_Intron	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	20					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						AGGATAGAGCCTCCTCAAATC	0.468			NA							Hereditary_Angioedema				9	45					7.48243e-07	1.03265e-06	0.006214	1	0
OR6Q1	219952	broad.mit.edu	37	11	57799225	57799225	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:57799225G>T	uc010rjz.1	+	1	801	c.801G>T	c.(799-801)AAG>AAT	p.K267N	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TCCAGACCAAGGTGACCTCCT	0.498			NA											12	85					2.27111e-07	3.21042e-07	0.001368	1	0
OR5A1	219982	broad.mit.edu	37	11	59210995	59210995	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:59210995G>T	uc001nnx.1	+	1	354	c.354G>T	c.(352-354)CTG>CTT	p.L118L		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GCCTCCTCCTGACTGCTATGG	0.532			NA											36	141					4.14481e-20	7.67791e-20	0.00623	1	0
OR4D11	219986	broad.mit.edu	37	11	59271184	59271184	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:59271184A>T	uc001noa.1	+	1	136	c.136A>T	c.(136-138)ATG>TTG	p.M46L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTCCTCATCATGGTCACCGT	0.483			NA											17	76					0	0	0.007413	0	0
CD6	923	broad.mit.edu	37	11	60739346	60739346	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:60739346C>A	uc001nqq.2	+	1	232	c.9C>A	c.(7-9)CTC>CTA	p.L3L	CD6_uc009yni.2_Silent_p.L3L|CD6_uc009ynj.2_Silent_p.L3L|CD6_uc001nqp.2_Silent_p.L3L|CD6_uc001nqr.2_Silent_p.L3L|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.L3L	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	3					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						ACATGTGGCTCTTCTTCGGGA	0.662	Pancreas(169;904 2017 4767 38890 42505)		NA											5	12					0.00116845	0.00130265	0.001168	1	0
C11orf66	220004	broad.mit.edu	37	11	61254452	61254452	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:61254452G>C	uc001nru.1	+	10	992	c.867G>C	c.(865-867)GTG>GTC	p.V289V	C11orf66_uc009ynq.1_Silent_p.V269V	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	289										ovary(1)	1						CCAGCAGCGTGAGTCACCAGC	0.607			NA											46	189					0	0	0.00361	0	0
AHNAK	79026	broad.mit.edu	37	11	62287559	62287559	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62287559T>A	uc001ntl.2	-	5	14630	c.14330A>T	c.(14329-14331)CAC>CTC	p.H4777L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4777					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CATCTTCAGGTGCCAGTCTGG	0.537			NA											36	172					0	0	0.005524	0	0
AHNAK	79026	broad.mit.edu	37	11	62301100	62301100	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62301100C>A	uc001ntl.2	-	5	1089	c.789G>T	c.(787-789)AAG>AAT	p.K263N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	263					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGTCCAAGCCCTTTGCATTGA	0.572			NA											16	60					2.31682e-05	2.9206e-05	0.003163	1	0
EML3	256364	broad.mit.edu	37	11	62378705	62378705	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62378705C>T	uc001ntu.1	-	3	614	c.306G>A	c.(304-306)CTG>CTA	p.L102L	EML3_uc001ntr.1_Silent_p.L74L|EML3_uc001nts.1_Silent_p.L74L|EML3_uc001ntt.1_5'UTR|EML3_uc010rly.1_Silent_p.L102L|EML3_uc009yny.1_5'UTR|ROM1_uc001ntv.2_5'Flank	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	102						cytoplasm|microtubule	protein binding			ovary(1)	1						GTCCATTGCTCAGGCCAGGGG	0.682			NA											4	18					0	0	0.009096	0	0
GANAB	23193	broad.mit.edu	37	11	62400518	62400518	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62400518C>T	uc001nub.2	-	8	807	c.774G>A	c.(772-774)GGG>GGA	p.G258G	GANAB_uc001nua.2_Silent_p.G280G|GANAB_uc001nuc.2_Silent_p.G161G|GANAB_uc010rma.1_Silent_p.G166G|GANAB_uc010rmb.1_Silent_p.G144G	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	258					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GCTCAGGGATCCCATAGACAT	0.522	Melanoma(23;1005 1074 15747 18937)		NA											6	36					0	0	0.001168	0	0
GANAB	23193	broad.mit.edu	37	11	62402453	62402453	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62402453C>T	uc001nub.2	-	5	433	c.400G>A	c.(400-402)GAT>AAT	p.D134N	GANAB_uc001nua.2_Missense_Mutation_p.D134N|GANAB_uc001nuc.2_Missense_Mutation_p.D37N|GANAB_uc010rma.1_Missense_Mutation_p.D20N|GANAB_uc010rmb.1_Missense_Mutation_p.D20N	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	134					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CTGTTCTCATCACGACCAGAG	0.468	Melanoma(23;1005 1074 15747 18937)		NA											10	59					0	0	0.008291	0	0
INTS5	80789	broad.mit.edu	37	11	62415445	62415445	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62415445C>T	uc001nud.2	-	2	2160	c.2107G>A	c.(2107-2109)GAA>AAA	p.E703K	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	703					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CCAAACAGTTCTGTGTTGCCT	0.552			NA											7	38					0	0	0.006214	0	0
INTS5	80789	broad.mit.edu	37	11	62415784	62415784	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62415784C>T	uc001nud.2	-	2	1821	c.1768G>A	c.(1768-1770)GAG>AAG	p.E590K	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	590					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GCAGGGCCCTCGCCACCCTGC	0.622			NA											5	33					0	0	0.000602	0	0
C11orf83	790955	broad.mit.edu	37	11	62439292	62439292	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62439292C>T	uc001nui.3	+	1	167	c.75C>T	c.(73-75)CTC>CTT	p.L25L	C11orf48_uc001nue.2_5'Flank|C11orf48_uc001nuf.2_5'Flank|C11orf48_uc010rmd.1_5'Flank	NM_001085372	NP_001078841	Q6UW78	CK083_HUMAN	hypothetical protein LOC790955 precursor	25						extracellular region					0						ACGCGCTCCTCGTTATCGTGA	0.642			NA											7	33					0	0	0.001984	0	0
UBXN1	51035	broad.mit.edu	37	11	62444306	62444306	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62444306C>G	uc001nul.1	-	8	955	c.823G>C	c.(823-825)GAG>CAG	p.E275Q	UBXN1_uc001nuj.2_Missense_Mutation_p.E275Q|UBXN1_uc001num.1_Missense_Mutation_p.E271Q|UBXN1_uc001nuk.2_3'UTR|UBXN1_uc010rme.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	275	UBX.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						AGAGGCCGCTCCATGTCAGCT	0.587			NA											24	106					0	0	0.003954	0	0
UBXN1	51035	broad.mit.edu	37	11	62444318	62444318	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62444318C>A	uc001nul.1	-	8	943	c.811G>T	c.(811-813)GAA>TAA	p.E271*	UBXN1_uc001nuj.2_Nonsense_Mutation_p.E271*|UBXN1_uc001num.1_Nonsense_Mutation_p.E267*|UBXN1_uc001nuk.2_3'UTR|UBXN1_uc010rme.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	271	UBX.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						ATGTCAGCTTCTGAGAAGGCC	0.592			NA											25	102					1.77063e-15	3.10607e-15	0.005443	1	0
UBXN1	51035	broad.mit.edu	37	11	62445457	62445457	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62445457C>T	uc001nul.1	-	5	556	c.424G>A	c.(424-426)GAG>AAG	p.E142K	UBXN1_uc001nuj.2_Missense_Mutation_p.E142K|UBXN1_uc001num.1_Missense_Mutation_p.E142K|UBXN1_uc001nuk.2_Missense_Mutation_p.E107K|UBXN1_uc010rme.1_Missense_Mutation_p.E142K|UBXN1_uc010rmf.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	142	Potential.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						CGGCGCATCTCATCTTCCTGT	0.577			NA											8	30					0	0	0.004482	0	0
UBXN1	51035	broad.mit.edu	37	11	62445970	62445970	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62445970C>G	uc001nul.1	-	3	349	c.217G>C	c.(217-219)GAA>CAA	p.E73Q	UBXN1_uc001nuj.2_Missense_Mutation_p.E73Q|UBXN1_uc001num.1_Missense_Mutation_p.E73Q|UBXN1_uc001nuk.2_Missense_Mutation_p.E38Q|UBXN1_uc010rme.1_Missense_Mutation_p.E73Q|UBXN1_uc010rmf.1_Missense_Mutation_p.E73Q	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	73	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						TCAGGACCTTCAAGGCCGCCT	0.532			NA											6	47					0	0	0.001984	0	0
UBXN1	51035	broad.mit.edu	37	11	62446042	62446042	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62446042C>A	uc001nul.1	-	3	277	c.145G>T	c.(145-147)GAC>TAC	p.D49Y	UBXN1_uc001nuj.2_Missense_Mutation_p.D49Y|UBXN1_uc001num.1_Missense_Mutation_p.D49Y|UBXN1_uc001nuk.2_Missense_Mutation_p.D14Y|UBXN1_uc010rme.1_Missense_Mutation_p.D49Y|UBXN1_uc010rmf.1_Missense_Mutation_p.D49Y	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	49	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						AAAGGCTCGTCCACATCGGGG	0.632			NA											5	39					0.000157383	0.000187214	0.00308	1	0
UBXN1	51035	broad.mit.edu	37	11	62446048	62446048	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62446048C>A	uc001nul.1	-	3	271	c.139G>T	c.(139-141)GAT>TAT	p.D47Y	UBXN1_uc001nuj.2_Missense_Mutation_p.D47Y|UBXN1_uc001num.1_Missense_Mutation_p.D47Y|UBXN1_uc001nuk.2_Missense_Mutation_p.D12Y|UBXN1_uc010rme.1_Missense_Mutation_p.D47Y|UBXN1_uc010rmf.1_Missense_Mutation_p.D47Y	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	47	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						TCGTCCACATCGGGGTCGTCT	0.637			NA											7	40					0.000442599	0.000512261	0.006214	1	0
UBXN1	51035	broad.mit.edu	37	11	62446178	62446178	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62446178C>T	uc001nul.1	-	2	229	c.97G>A	c.(97-99)GAG>AAG	p.E33K	UBXN1_uc001nuj.2_Missense_Mutation_p.E33K|UBXN1_uc001num.1_Missense_Mutation_p.E33K|UBXN1_uc001nuk.2_5'UTR|UBXN1_uc010rme.1_Missense_Mutation_p.E33K|UBXN1_uc010rmf.1_Missense_Mutation_p.E33K	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	33	UBA.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						ATCGCAGCCTCGATGCCCTGG	0.652			NA											4	11					0	0	0.009096	0	0
GNG3	2785	broad.mit.edu	37	11	62476249	62476249	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62476249G>T	uc001nuv.2	+	3	474	c.199G>T	c.(199-201)GAG>TAG	p.E67*	BSCL2_uc001nuo.1_5'Flank|BSCL2_uc009yoc.1_5'Flank|BSCL2_uc001nup.2_5'Flank|BSCL2_uc001nuq.1_5'Flank|BSCL2_uc001nur.3_5'Flank|BSCL2_uc009yod.2_Intron|BSCL2_uc001nut.3_Intron|HNRNPUL2_uc001nuu.1_Intron	NM_012202	NP_036334	P63215	GBG3_HUMAN	guanine nucleotide binding protein (G protein),	67					activation of MAPK activity|cellular response to glucagon stimulus|energy reserve metabolic process|synaptic transmission		GTPase activity|signal transducer activity				0						CCCCTTCCGGGAGAAGAAGTT	0.567			NA											11	53					1.61879e-10	2.59577e-10	0.001368	1	0
TTC9C	283237	broad.mit.edu	37	11	62502894	62502894	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62502894G>T	uc001nuy.2	+	2	648	c.279G>T	c.(277-279)GTG>GTT	p.V93V	TTC9C_uc001nux.2_Silent_p.V226V	NM_173810	NP_776171	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	93	TPR 2.						binding			ovary(1)|pancreas(1)	2						ACGAACGAGTGAGAGAATATA	0.512			NA											9	42					3.86212e-05	4.78167e-05	0.008291	1	0
TTC9C	283237	broad.mit.edu	37	11	62502931	62502931	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:62502931G>C	uc001nuy.2	+	2	685	c.316G>C	c.(316-318)GAT>CAT	p.D106H	TTC9C_uc001nux.2_Missense_Mutation_p.D239H	NM_173810	NP_776171	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	106	TPR 2.						binding			ovary(1)|pancreas(1)	2						ACGACAGCCTGATAATGCCAA	0.532			NA											10	42					0	0	0.000978	0	0
SLC22A12	116085	broad.mit.edu	37	11	64360942	64360942	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:64360942C>A	uc001oam.1	+	3	1319	c.572C>A	c.(571-573)GCC>GAC	p.A191D	SLC22A12_uc009ypr.1_Missense_Mutation_p.A191D|SLC22A12_uc001oal.1_Intron|SLC22A12_uc009yps.1_Intron|SLC22A12_uc001oan.1_Intron|SLC22A12_uc009ypt.2_Missense_Mutation_p.A9D	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	191	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						ACGGCAGCTGCCTTCGCCCCT	0.617			NA											7	49					1.12685e-05	1.44938e-05	0.004482	1	0
NRXN2	9379	broad.mit.edu	37	11	64419599	64419599	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:64419599C>T	uc001oar.2	-	14	2883	c.2444G>A	c.(2443-2445)GGG>GAG	p.G815E	NRXN2_uc001oas.2_Missense_Mutation_p.G775E|NRXN2_uc001oaq.2_Missense_Mutation_p.G482E	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GAGCTTGTGCCCCGCAAACAG	0.572			NA											6	15					0	0	0.001168	0	0
TM7SF2	7108	broad.mit.edu	37	11	64883491	64883491	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:64883491G>C	uc001oct.2	+	10	1370	c.1223G>C	c.(1222-1224)CGT>CCT	p.R408P	TM7SF2_uc010rny.1_Missense_Mutation_p.R292P|TM7SF2_uc001ocu.2_Missense_Mutation_p.R381P|TM7SF2_uc001ocv.2_Missense_Mutation_p.R429P|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	408					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						TACTGCCGGCGTGTGCCTTAC	0.647			NA											7	22					0	0	0.008291	0	0
SF3B2	10992	broad.mit.edu	37	11	65823007	65823007	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:65823007A>C	uc001ogy.1	+	5	540	c.500A>C	c.(499-501)CAG>CCG	p.Q167P	SF3B2_uc001ogx.1_Splice_Site_p.G167_splice	NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	167	Potential.				interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						TTTTTTAAGCAGGGAGATCAT	0.502			NA											4	34					0	0	0.009096	0	0
RAB1B	81876	broad.mit.edu	37	11	66039310	66039310	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:66039310G>T	uc001ohf.2	+	2	152	c.57G>T	c.(55-57)GTG>GTT	p.V19V	uc001ohg.1_RNA	NM_030981	NP_112243	Q9H0U4	RAB1B_HUMAN	RAB1B, member RAS oncogene family	19	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	Golgi apparatus|membrane	GTP binding|protein binding				0						ACTCAGGCGTGGGCAAGTCAT	0.577			NA											8	37					0.000274275	0.000319476	0.004482	1	0
B3GNT1	11041	broad.mit.edu	37	11	66114503	66114503	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:66114503C>A	uc001ohr.2	-	1	659	c.514G>T	c.(514-516)GAG>TAG	p.E172*	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	172	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						TCCCCCGGCTCCCGGGGGTCG	0.682			NA											4	15					0.00024832	0.000292993	0.009096	1	0
ACTN3	89	broad.mit.edu	37	11	66328121	66328121	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:66328121C>T	uc001oio.1	+	16	1773	c.1755C>T	c.(1753-1755)ATC>ATT	p.I585I	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	585	Spectrin 3.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						TCATGGGCATCCAGGGTGAGA	0.607			NA											11	52					0	0	0.008291	0	0
SPTBN2	6712	broad.mit.edu	37	11	66483327	66483327	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:66483327G>A	uc001ojd.2	-	3	355	c.283C>T	c.(283-285)CTC>TTC	p.L95F		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	95	CH 1.|Actin-binding.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGCACCTCGAGGAGCCTCAGC	0.622			NA											10	15					0	0	0.006214	0	0
C11orf80	79703	broad.mit.edu	37	11	66605891	66605891	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:66605891T>A	uc001ojf.2	+	15	1729	c.1722T>A	c.(1720-1722)GAT>GAA	p.D574E	C11orf80_uc001ojg.2_Missense_Mutation_p.D341E|C11orf80_uc001ojh.2_Missense_Mutation_p.D342E|C11orf80_uc001oji.2_Missense_Mutation_p.D342E|C11orf80_uc010rpl.1_Missense_Mutation_p.D208E|C11orf80_uc001ojj.2_Missense_Mutation_p.D172E	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	419											0						ACGCACCTGATAACAGCAGCC	0.443			NA											7	21					0	0	0.001984	0	0
LRP5	4041	broad.mit.edu	37	11	68157355	68157355	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:68157355G>T	uc001ont.2	+	7	1494	c.1419G>T	c.(1417-1419)ATG>ATT	p.M473I	LRP5_uc009ysg.2_Intron	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	473	LDL-receptor class B 8.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CCAGCCTCATGTACTGGACAG	0.403			NA											10	41					2.68362e-12	4.45536e-12	0.001368	1	0
ANKRD42	338699	broad.mit.edu	37	11	82938914	82938914	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:82938914G>T	uc001ozz.1	+	7	1251	c.829G>T	c.(829-831)GCT>TCT	p.A277S	ANKRD42_uc010rsv.1_Missense_Mutation_p.A305S|ANKRD42_uc001paa.2_Missense_Mutation_p.A305S|ANKRD42_uc001pab.1_Missense_Mutation_p.A304S	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	277	ANK 8.									skin(1)	1						TATGCATAAAGGTGAGTTATG	0.353			NA											12	54					6.31663e-08	9.21544e-08	0.003163	1	0
GRM5	2915	broad.mit.edu	37	11	88583117	88583117	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:88583117T>C	uc001pcq.2	-	2	1068	c.868A>G	c.(868-870)ATG>GTG	p.M290V	GRM5_uc009yvm.2_Missense_Mutation_p.M290V	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	290	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGGCGCCTCATGGCCATCAGC	0.517			NA											9	47					0	0	0.004482	0	0
FOLH1B	219595	broad.mit.edu	37	11	89420534	89420534	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:89420534G>T	uc001pda.2	+	9	1062	c.536G>T	c.(535-537)GGC>GTC	p.G179V		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	179					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						CCTGATGAAGGCTTTGAAGGC	0.343			NA											5	35					0.000602214	0.000682885	0.000602	1	0
NAALAD2	10003	broad.mit.edu	37	11	89916115	89916115	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:89916115C>T	uc001pdf.3	+	18	2081	c.1972C>T	c.(1972-1974)CTG>TTG	p.L658L	NAALAD2_uc009yvx.2_Silent_p.L625L|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	658	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GAATGACCAACTGATGCTCCT	0.388			NA											7	67					0	0	0.004482	0	0
FAT3	120114	broad.mit.edu	37	11	92526085	92526085	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:92526085G>T	uc001pdj.3	+	8	4781	c.4764G>T	c.(4762-4764)GTG>GTT	p.V1588V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1588	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTCTGCAAGTGACGGCTCTGG	0.448			NA								TCGA Ovarian(4;0.039)			9	38					5.4927e-09	8.34799e-09	0.004482	1	0
MTNR1B	4544	broad.mit.edu	37	11	92715442	92715442	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:92715442C>A	uc001pdk.1	+	2	1156	c.1053C>A	c.(1051-1053)CCC>CCA	p.P351P		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	351	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CAGCTCCACCCATCATTGGTG	0.567			NA											11	70					3.86212e-05	4.78167e-05	0.008291	1	0
KDM4D	55693	broad.mit.edu	37	11	94731714	94731714	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:94731714G>T	uc001pfe.2	+	3	2010	c.1178G>T	c.(1177-1179)AGT>ATT	p.S393I		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	393					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCTGCCCGCAGTGGGACACGG	0.637			NA											6	23					0.00116845	0.00130265	0.001168	1	0
PGR	5241	broad.mit.edu	37	11	100912825	100912825	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:100912825C>A	uc001pgh.2	-	7	3240	c.2497G>T	c.(2497-2499)GAA>TAA	p.E833*	PGR_uc001pgg.2_Nonsense_Mutation_p.E214*|PGR_uc001pgi.2_Nonsense_Mutation_p.E731*|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	833	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CGTAGCCCTTCCAAAGGAACT	0.363	Pancreas(124;2271 2354 21954 22882)		NA											15	33					1.49906e-05	1.90125e-05	0.00245	1	0
ANGPTL5	253935	broad.mit.edu	37	11	101762183	101762183	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:101762183C>G	uc001pgl.2	-	9	1590	c.994G>C	c.(994-996)GGC>CGC	p.G332R		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	332	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		AACCACCAGCCGGTCTTGTTA	0.478			NA											20	71					0	0	0.001882	0	0
BIRC3	330	broad.mit.edu	37	11	102201846	102201846	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:102201846C>T	uc001pgx.2	+	7	1420	c.1198C>T	c.(1198-1200)CAG>TAG	p.Q400*		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	400					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		ACAGACAGTTCAGAGAAAAAT	0.398			NA	T	MALT1	MALT								10	47					0	0	0.006214	0	0
MMP27	64066	broad.mit.edu	37	11	102573517	102573517	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:102573517C>G	uc001phd.1	-	4	609	c.586G>C	c.(586-588)GAT>CAT	p.D196H		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	196		Calcium 3 (By similarity).			collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TCATCCTCATCAAAATGAGTG	0.453			NA											20	75					0	0	0.001882	0	0
DDI1	414301	broad.mit.edu	37	11	103908012	103908012	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:103908012C>A	uc001phr.2	+	1	705	c.462C>A	c.(460-462)CCC>CCA	p.P154P	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	154					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TCTCCAACCCCCACGATCTGT	0.637			NA											8	34					5.18039e-06	6.82593e-06	0.00308	1	0
AASDHPPT	60496	broad.mit.edu	37	11	105967474	105967474	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:105967474C>T	uc001pjc.1	+	6	916	c.770C>T	c.(769-771)CCA>CTA	p.P257L	AASDHPPT_uc010rvn.1_RNA|AASDHPPT_uc001pjd.1_Missense_Mutation_p.P110L	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	257					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		TTTTAGGTTCCATCTCAGGAT	0.333			NA											9	53					0	0	0.004482	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106558347	106558347	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:106558347A>G	uc001pjg.1	-	8	2517	c.2127T>C	c.(2125-2127)TCT>TCC	p.S709S	GUCY1A2_uc010rvo.1_Silent_p.S730S|GUCY1A2_uc009yxn.1_Silent_p.S740S	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	709					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ACGAAGAAAGAGAAGGCTTTG	0.493			NA											16	88					0	0	0.007413	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106579268	106579268	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:106579268C>T	uc001pjg.1	-	7	2351	c.1961G>A	c.(1960-1962)CGG>CAG	p.R654Q	GUCY1A2_uc010rvo.1_Missense_Mutation_p.R675Q|GUCY1A2_uc009yxn.1_Missense_Mutation_p.R685Q	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	654					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ATTGATGCGCCGAGGGTGACT	0.522			NA											4	26					0	0	0.000602	0	0
ELMOD1	55531	broad.mit.edu	37	11	107535886	107535886	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:107535886C>A	uc010rvs.1	+	12	1372	c.968C>A	c.(967-969)CCA>CAA	p.P323Q	ELMOD1_uc001pjm.2_Missense_Mutation_p.P315Q|ELMOD1_uc010rvt.1_Missense_Mutation_p.P317Q	NM_018712	NP_061182	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1 isoform 1	323					phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		GCGCTGTGCCCACATTTTGCT	0.483			NA											11	80					1.58986e-06	2.14735e-06	0.008291	1	0
BCO2	83875	broad.mit.edu	37	11	112065384	112065384	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:112065384G>T	uc001pnf.2	+	5	759	c.642G>T	c.(640-642)TGG>TGT	p.W214C	BCO2_uc001pne.1_Missense_Mutation_p.W41C|BCO2_uc001png.2_Intron|BCO2_uc001pnh.2_Missense_Mutation_p.W180C|BCO2_uc010rwt.1_Missense_Mutation_p.W109C|BCO2_uc009yyn.2_Missense_Mutation_p.W180C|BCO2_uc001pni.2_Missense_Mutation_p.W180C	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	214					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGGTAGATTGGAGCAAATTTA	0.368	GBM(177;1916 2099 21049 29541 39946)		NA											12	54					0.00010058	0.000121128	0.001368	1	0
DRD2	1813	broad.mit.edu	37	11	113283382	113283382	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:113283382G>T	uc001pnz.2	-	6	1355	c.1034C>A	c.(1033-1035)ACC>AAC	p.T345N	DRD2_uc010rwv.1_Missense_Mutation_p.T344N|DRD2_uc001poa.3_Missense_Mutation_p.T345N|DRD2_uc001pob.3_Missense_Mutation_p.T316N	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	345	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	ATTGGGCATGGTCTGGATCTC	0.552			NA											9	49					3.09899e-07	4.35533e-07	0.004482	1	0
CEP164	22897	broad.mit.edu	37	11	117257992	117257992	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:117257992G>T	uc001prc.2	+	15	1945	c.1798G>T	c.(1798-1800)GCC>TCC	p.A600S	CEP164_uc001prb.2_Missense_Mutation_p.A603S|CEP164_uc010rxk.1_Missense_Mutation_p.A574S|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.A33S	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	600	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		AGAGGCAGTGGCCCAAGTACT	0.572			NA											8	63					0.00307968	0.0033563	0.00308	1	0
CD3D	915	broad.mit.edu	37	11	118210166	118210166	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:118210166C>G	uc001pss.1	-	4	587	c.450G>C	c.(448-450)CAG>CAC	p.Q150H	CD3D_uc001pst.1_Missense_Mutation_p.Q106H	NM_000732	NP_000723	P04234	CD3D_HUMAN	CD3 antigen, delta subunit isoform A precursor	150	ITAM.|Cytoplasmic (Potential).				positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CAACGCTCACCTGATAGACCT	0.542			NA											8	46					0	0	0.001368	0	0
MLL	4297	broad.mit.edu	37	11	118363824	118363824	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:118363824G>C	uc001pta.2	+	16	5071	c.5048G>C	c.(5047-5049)CGC>CCC	p.R1683P	MLL_uc001ptb.2_Missense_Mutation_p.R1686P	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1683					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ATACCTTCCCGCAGCTCCCCC	0.483			NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								14	45					0	0	0.003163	0	0
BCL9L	283149	broad.mit.edu	37	11	118771514	118771514	+	Missense_Mutation	SNP	C	C	A	rs150094487		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:118771514C>A	uc001pug.2	-	6	3903	c.2938G>T	c.(2938-2940)GGC>TGC	p.G980C	BCL9L_uc009zal.2_Missense_Mutation_p.G975C	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	980	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		AGGGAGGAGCCGAGGACCTGG	0.637			NA											7	37					0.000673444	0.000757755	0.008291	1	0
ABCG4	64137	broad.mit.edu	37	11	119024758	119024758	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:119024758C>T	uc001pvs.2	+	3	597	c.261C>T	c.(259-261)TGC>TGT	p.C87C	ABCG4_uc009zar.2_Silent_p.C87C|ABCG4_uc001pvt.1_RNA	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	87	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TTCTCAAGTGCCTCTCAGGTA	0.517			NA											11	68					0	0	0.001368	0	0
NLRX1	79671	broad.mit.edu	37	11	119045184	119045184	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:119045184G>T	uc001pvu.2	+	6	1087	c.872G>T	c.(871-873)CGG>CTG	p.R291L	NLRX1_uc010rzc.1_Missense_Mutation_p.R113L|NLRX1_uc001pvv.2_Missense_Mutation_p.R291L|NLRX1_uc001pvw.2_Missense_Mutation_p.R291L|NLRX1_uc001pvx.2_Missense_Mutation_p.R291L	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	291	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTGACCACTCGGCCCTCTGCC	0.547			NA											30	109					1.61788e-16	2.88327e-16	0.002445	1	0
GRIK4	2900	broad.mit.edu	37	11	120732757	120732757	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:120732757C>T	uc001pxn.2	+	9	1121	c.834C>T	c.(832-834)TTC>TTT	p.F278F	GRIK4_uc009zav.1_Silent_p.F278F|GRIK4_uc009zaw.1_Silent_p.F278F|GRIK4_uc009zax.1_Silent_p.F278F	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	278	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ATGCTTTCTTCCAAGAGTTTG	0.527			NA											23	182					0	0	0.004656	0	0
TMEM225	338661	broad.mit.edu	37	11	123754007	123754007	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:123754007C>T	uc001pzi.2	-	4	724	c.516G>A	c.(514-516)CTG>CTA	p.L172L		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	172						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						TATGGATGTTCAGGCAGGTAC	0.453			NA											8	38					0	0	0.00308	0	0
OR6T1	219874	broad.mit.edu	37	11	123814154	123814154	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:123814154C>A	uc010sab.1	-	1	392	c.392G>T	c.(391-393)CGC>CTC	p.R131L		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGTCTCATAGCGGAGTGGTCG	0.547			NA											5	13					1.024e-07	1.48648e-07	0.000602	1	0
ROBO3	64221	broad.mit.edu	37	11	124748584	124748584	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:124748584C>T	uc001qbc.2	+	23	3617	c.3425C>T	c.(3424-3426)CCC>CTC	p.P1142L	ROBO3_uc001qbd.2_Missense_Mutation_p.P67L|ROBO3_uc010sar.1_Missense_Mutation_p.P191L|ROBO3_uc001qbe.2_Missense_Mutation_p.P67L|ROBO3_uc001qbf.1_Missense_Mutation_p.P26L	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1142	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		AGGGAAACCCCCTCTCCCACA	0.627			NA											7	12					0	0	0.00308	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343102	130343102	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:130343102G>T	uc010scd.1	+	8	2239	c.2239G>T	c.(2239-2241)GAG>TAG	p.E747*		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	747	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GTCGGCGGTGGAGCGGGACCT	0.642			NA											8	44					0.000274275	0.000319476	0.004482	1	0
NTM	50863	broad.mit.edu	37	11	132177605	132177605	+	Missense_Mutation	SNP	C	C	A	rs138880898		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:132177605C>A	uc001qgp.2	+	4	1213	c.549C>A	c.(547-549)GAC>GAA	p.D183E	NTM_uc001qgm.2_Missense_Mutation_p.D183E|NTM_uc010sch.1_Missense_Mutation_p.D174E|NTM_uc010sci.1_Missense_Mutation_p.D183E|NTM_uc010scj.1_Missense_Mutation_p.D142E|NTM_uc001qgo.2_Missense_Mutation_p.D183E|NTM_uc001qgq.2_Missense_Mutation_p.D183E|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	183	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						TGAGTGAAGACGAATACTTGG	0.493			NA											5	32					0.000602214	0.000682885	0.000602	1	0
NTM	50863	broad.mit.edu	37	11	132204969	132204969	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:132204969G>T	uc001qgp.2	+	7	1628	c.964G>T	c.(964-966)GGC>TGC	p.G322C	NTM_uc001qgm.2_Missense_Mutation_p.G322C|NTM_uc010sch.1_Missense_Mutation_p.G324C|NTM_uc010sci.1_Missense_Mutation_p.G333C|NTM_uc010scj.1_Missense_Mutation_p.G281C|NTM_uc001qgq.2_Missense_Mutation_p.G333C|NTM_uc001qgr.2_Missense_Mutation_p.G104C	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	322					cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GGTGAGCAACGGCACGTCGAG	0.602			NA											6	83					2.0095e-06	2.69165e-06	0.001984	1	0
RAD51AP1	10635	broad.mit.edu	37	12	4665604	4665604	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:4665604T>C	uc001qmw.2	+	9	1014	c.858T>C	c.(856-858)ACT>ACC	p.T286T	RAD51AP1_uc001qmu.2_Silent_p.T269T|RAD51AP1_uc001qmv.2_Silent_p.T232T|RAD51AP1_uc010sep.1_Silent_p.T151T|RAD51AP1_uc010seq.1_Silent_p.T151T|RAD51AP1_uc009zeg.2_Intron	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	286					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			CAGATACCACTAGGAAACCAT	0.433			NA											14	43					0	0	0.00245	0	0
PEX5	5830	broad.mit.edu	37	12	7362816	7362816	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:7362816G>T	uc009zfu.1	+	17	2497	c.1917G>T	c.(1915-1917)CAG>CAT	p.Q639H	PEX5_uc001qsw.2_Missense_Mutation_p.Q639H|PEX5_uc010sgc.1_Missense_Mutation_p.Q654H|PEX5_uc001qsu.2_Missense_Mutation_p.Q602H|PEX5_uc010sgd.1_Missense_Mutation_p.Q660H|PEX5_uc001qsv.2_Missense_Mutation_p.Q631H	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d	639					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						GCCTGCCCCAGTGACAGTGGG	0.622			NA											12	37					0.00010058	0.000121128	0.001368	1	0
C3AR1	719	broad.mit.edu	37	12	8211786	8211786	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:8211786G>T	uc001qtv.1	-	2	1088	c.996C>A	c.(994-996)CCC>CCA	p.P332P		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	332	Extracellular (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		TTGCCACGAGGGGTGTTGGCA	0.473			NA											8	63					0.000274275	0.000319476	0.004482	1	0
A2M	2	broad.mit.edu	37	12	9225254	9225254	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:9225254G>T	uc001qvk.1	-	30	4083	c.3970C>A	c.(3970-3972)CTC>ATC	p.L1324I	A2M_uc001qvj.1_Missense_Mutation_p.L366I|A2M_uc009zgk.1_Missense_Mutation_p.L1174I	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1324					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CTCACCTGGAGGTAGACACAT	0.517			NA											13	74					0.00244969	0.00268581	0.00245	1	0
CLEC12A	160364	broad.mit.edu	37	12	10133289	10133289	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:10133289C>T	uc001qwr.3	+	4	676	c.488C>T	c.(487-489)GCT>GTT	p.A163V	CLEC12A_uc001qwq.2_Missense_Mutation_p.A173V|CLEC12A_uc001qws.3_Missense_Mutation_p.A130V|CLEC12A_uc001qwt.2_Missense_Mutation_p.A92V	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	163	Extracellular (Potential).|C-type lectin.					integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						GCCTGTGCTGCTCAGAATGCC	0.453	Melanoma(197;1487 2125 16611 22221 34855)		NA											11	47					0	0	0.008291	0	0
CSDA	8531	broad.mit.edu	37	12	10871718	10871718	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:10871718T>C	uc001qyt.2	-	2	530	c.287A>G	c.(286-288)AAA>AGA	p.K96R	CSDA_uc001qyu.2_Missense_Mutation_p.K96R	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	96	CSD.				negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					GTTGAACCATTTGACAGTGCC	0.348			NA											12	36					0	0	0.00245	0	0
PRB1	5542	broad.mit.edu	37	12	11506880	11506880	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:11506880G>T	uc001qzw.1	-	3	194	c.157C>A	c.(157-159)CCT>ACT	p.P53T	PRB1_uc001qzu.1_Missense_Mutation_p.P53T|PRB1_uc001qzv.1_Missense_Mutation_p.P53T	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	53	1.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].					extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGAGGTGGGGGG	0.577			NA											25	141					1.71298e-08	2.55543e-08	0.003755	1	0
PTPRO	5800	broad.mit.edu	37	12	15733636	15733636	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:15733636C>T	uc001rcv.1	+	22	3177	c.3003C>T	c.(3001-3003)TAC>TAT	p.Y1001Y	PTPRO_uc001rcw.1_Silent_p.Y973Y|PTPRO_uc001rcx.1_Silent_p.Y190Y|PTPRO_uc001rcy.1_Silent_p.Y190Y|PTPRO_uc001rcz.1_Silent_p.Y162Y|PTPRO_uc001rda.1_Silent_p.Y162Y	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1001	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				TTCAGGGATACAACTCACCCC	0.438			NA											11	42					0	0	0.008291	0	0
PDE3A	5139	broad.mit.edu	37	12	20806975	20806975	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:20806975A>G	uc001reh.1	+	15	3042	c.3020A>G	c.(3019-3021)CAC>CGC	p.H1007R		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1007	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TTCATCTCTCACATTGTGGGG	0.507			NA											7	37					0	0	0.001984	0	0
ABCC9	10060	broad.mit.edu	37	12	22040803	22040803	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:22040803T>G	uc001rfi.1	-	13	1888	c.1868A>C	c.(1867-1869)GAA>GCA	p.E623A	ABCC9_uc001rfh.2_Missense_Mutation_p.E623A|ABCC9_uc001rfj.1_Missense_Mutation_p.E623A	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	623	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAGCGAACTTTCACCAGTTCG	0.393			NA											15	57					0	0	0.004007	0	0
ETNK1	55500	broad.mit.edu	37	12	22811970	22811970	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:22811970A>C	uc001rft.2	+	3	728	c.706A>C	c.(706-708)AAA>CAA	p.K236Q	ETNK1_uc009ziz.2_Missense_Mutation_p.K236Q	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	236				RLIARQLAKIHAIHAHNGWIPKSNLWLKMGK -> SLSSLT LCKGKTTRCFGLTGCRGSRLLLSFF (in Ref. 2; AAH06111).	phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						TCAGCTTGCTAAAATCCATGC	0.348	Esophageal Squamous(42;87 913 3224 6226 43339)		NA											10	39					0	0	0.001368	0	0
LRMP	4033	broad.mit.edu	37	12	25232384	25232384	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:25232384A>G	uc001rgh.2	+	7	1158	c.124A>G	c.(124-126)ATA>GTA	p.I42V	LRMP_uc001rgg.1_RNA|LRMP_uc010sja.1_Missense_Mutation_p.I42V|LRMP_uc010sjb.1_5'UTR|LRMP_uc001rgi.2_RNA|LRMP_uc010sjc.1_Missense_Mutation_p.I42V|LRMP_uc010sjd.1_5'UTR	NM_006152	NP_006143	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	98	Cytoplasmic (Potential).				vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					AGACGGTACTATAACTTCAAG	0.393			NA											23	59					0	0	0.00278	0	0
ITPR2	3709	broad.mit.edu	37	12	26568288	26568288	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:26568288C>A	uc001rhg.2	-	51	7671	c.7254G>T	c.(7252-7254)AAG>AAT	p.K2418N	ITPR2_uc009zjg.1_Missense_Mutation_p.K569N	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2418	Extracellular (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TGAAGTCATCCTTCAAAAAAA	0.408			NA											17	53					1.55795e-14	2.68129e-14	0.001882	1	0
TMTC1	83857	broad.mit.edu	37	12	29908738	29908738	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:29908738C>A	uc001rjb.2	-	4	785	c.311G>T	c.(310-312)GGG>GTG	p.G104V	TMTC1_uc001rjc.1_Missense_Mutation_p.G104V	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	212	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CGCACAGGTCCCCAGAAACAA	0.493			NA											4	28					0.00024832	0.000292993	0.009096	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30883196	30883196	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:30883196G>A	uc001rji.1	-	7	1832	c.1081C>T	c.(1081-1083)CAG>TAG	p.Q361*	CAPRIN2_uc001rjf.1_Nonsense_Mutation_p.Q158*|CAPRIN2_uc001rjg.1_Nonsense_Mutation_p.Q28*|CAPRIN2_uc001rjh.1_Nonsense_Mutation_p.Q361*|CAPRIN2_uc001rjj.1_Nonsense_Mutation_p.Q28*|CAPRIN2_uc001rjk.3_Nonsense_Mutation_p.Q361*|CAPRIN2_uc001rjl.3_Nonsense_Mutation_p.Q361*|CAPRIN2_uc001rjm.1_Nonsense_Mutation_p.Q28*|CAPRIN2_uc001rjn.1_Nonsense_Mutation_p.Q28*	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	361					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					ATCTCTGGCTGGGCAAATTCC	0.289			NA											6	29					0	0	0.001168	0	0
PKP2	5318	broad.mit.edu	37	12	32977015	32977015	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:32977015G>A	uc001rlj.3	-	8	1885	c.1770C>T	c.(1768-1770)GTC>GTT	p.V590V	PKP2_uc001rlk.3_Silent_p.V546V|PKP2_uc010skj.1_Silent_p.V546V	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	590	ARM 4.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGGTTCCTCTGACATAATGGA	0.388			NA											5	42					0	0	0.001984	0	0
PKP2	5318	broad.mit.edu	37	12	33031388	33031389	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:33031388_33031389CC>AA	uc001rlj.3	-	3	540_541	c.425_426GG>TT	c.(424-426)AGG>ATT	p.R142I	PKP2_uc001rlk.3_Missense_Mutation_p.R142I|PKP2_uc010skj.1_Missense_Mutation_p.R142I	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	142					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TCAGAGGATGCCTCAAGGACCT	0.569			NA											44	179					0	0	0.004672	0	0
KIF21A	55605	broad.mit.edu	37	12	39705243	39705243	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:39705243C>T	uc001rly.2	-	32	4218	c.4072G>A	c.(4072-4074)GAT>AAT	p.D1358N	KIF21A_uc001rlv.2_Missense_Mutation_p.D303N|KIF21A_uc001rlw.2_Missense_Mutation_p.D628N|KIF21A_uc001rlx.2_Missense_Mutation_p.D1345N|KIF21A_uc001rlz.2_Missense_Mutation_p.D1305N|KIF21A_uc010skl.1_Missense_Mutation_p.D1321N|KIF21A_uc001rlt.2_5'UTR|KIF21A_uc001rlu.2_5'UTR	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1358	WD 1.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				AAGAGGAGATCATCAGTAGAA	0.338			NA											13	62					0	0	0.001855	0	0
LRRK2	120892	broad.mit.edu	37	12	40689247	40689247	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:40689247C>T	uc001rmg.3	+	23	3018	c.2897C>T	c.(2896-2898)TCC>TTC	p.S966F	LRRK2_uc001rmh.1_Missense_Mutation_p.S588F|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	966					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AAACTTCAATCCCATATGAGG	0.279			NA											6	47					0	0	0.001168	0	0
CNTN1	1272	broad.mit.edu	37	12	41323782	41323782	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:41323782C>A	uc001rmm.1	+	7	794	c.681C>A	c.(679-681)ATC>ATA	p.I227I	CNTN1_uc009zjy.1_Silent_p.I227I|CNTN1_uc001rmn.1_Silent_p.I216I|CNTN1_uc001rmo.2_Silent_p.I227I	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	227					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GCAAATTCATCCCACTCATTC	0.363			NA											17	106					8.60227e-14	1.46662e-13	0.004007	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43826486	43826486	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:43826486C>A	uc010skx.1	-	20	2849	c.2849G>T	c.(2848-2850)GGT>GTT	p.G950V	ADAMTS20_uc001rno.1_Missense_Mutation_p.G104V|ADAMTS20_uc001rnp.1_Missense_Mutation_p.G104V	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	950	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGCTGGTCACCACAGTAGTG	0.413			NA											9	56					1.58986e-06	2.14735e-06	0.008291	1	0
IRAK4	51135	broad.mit.edu	37	12	44167770	44167770	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:44167770G>T	uc001rnu.3	+	7	784	c.654G>T	c.(652-654)ATG>ATT	p.M218I	IRAK4_uc001rnt.3_Missense_Mutation_p.M218I|IRAK4_uc001rnx.3_Missense_Mutation_p.M94I|IRAK4_uc001rny.3_Missense_Mutation_p.M94I|IRAK4_uc010sky.1_Missense_Mutation_p.M94I|IRAK4_uc001rnv.3_Missense_Mutation_p.M94I|IRAK4_uc001rnw.3_Missense_Mutation_p.M94I	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	218	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TTTTTCAGATGGTTGACATTA	0.294			NA											3	19					0.004672	0.00503511	0.004672	1	0
SLC38A4	55089	broad.mit.edu	37	12	47186734	47186734	+	Splice_Site	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:47186734A>T	uc001rpi.2	-	3	518	c.119_splice	c.e3+1	p.S40_splice	SLC38A4_uc001rpj.2_Splice_Site_p.S40_splice|SLC38A4_uc009zkl.2_Splice_Site_p.S40_splice	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4						cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					TTAACCCCATACCTGCTCATT	0.408			NA											36	146					0	0	0.006999	0	0
ADCY6	112	broad.mit.edu	37	12	49170083	49170083	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:49170083T>A	uc001rsh.3	-	7	2246	c.1586A>T	c.(1585-1587)GAG>GTG	p.E529V	ADCY6_uc001rsj.3_Missense_Mutation_p.E529V|ADCY6_uc001rsi.3_Missense_Mutation_p.E529V|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	529	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						TGGCTCCACCTCGTAGTCCCC	0.627			NA											9	34					0	0	0.006214	0	0
WNT10B	7480	broad.mit.edu	37	12	49360250	49360250	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:49360250T>A	uc001rss.2	-	5	1144	c.798A>T	c.(796-798)CCA>CCT	p.P266P	WNT10B_uc001rst.2_3'UTR	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	266					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						CCCGGAACTCTGGGGCCGCCC	0.607			NA											3	34					0	0	0.009096	0	0
MCRS1	10445	broad.mit.edu	37	12	49959862	49959862	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:49959862G>T	uc001ruk.1	-	3	338	c.147C>A	c.(145-147)TCC>TCA	p.S49S	MCRS1_uc001rui.1_Silent_p.S62S|MCRS1_uc001ruj.1_Silent_p.S36S|MCRS1_uc001rul.1_Silent_p.S49S|MCRS1_uc009zlj.1_Intron|MCRS1_uc001rum.1_Silent_p.S36S|MCRS1_uc001run.1_Silent_p.S49S	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	49	Ser-rich.				DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						CTTACTACCTGGAGGAGCTTC	0.607			NA											15	76					5.3912e-06	7.08447e-06	0.006122	1	0
FIGNL2	401720	broad.mit.edu	37	12	52215878	52215878	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:52215878G>T	uc001rzc.2	-	1	331	c.320C>A	c.(319-321)CCC>CAC	p.P107H		NM_001013690	NP_001013712	A6NMB9	FIGL2_HUMAN	fidgetin-like 2	107							ATP binding|nucleoside-triphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(357;0.135)		TGAGGCCAAGGGGTAGGGTGG	0.711			NA											3	8					0.004672	0.00503511	0.004672	1	0
KRT6B	3854	broad.mit.edu	37	12	52845437	52845437	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:52845437C>A	uc001sak.2	-	1	474	c.426G>T	c.(424-426)CAG>CAT	p.Q142H		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	142	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCAGGAGACTCTGGTTGACAG	0.622			NA											9	77					2.74318e-10	4.36034e-10	0.006214	1	0
KRT5	3852	broad.mit.edu	37	12	52912811	52912811	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:52912811A>T	uc001san.2	-	2	852	c.689T>A	c.(688-690)CTG>CAG	p.L230Q	KRT5_uc009zmh.2_Missense_Mutation_p.L230Q	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	230	Rod.|Coil 1B.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GATGCTGTCCAGCTGCCTCCT	0.587			NA											21	121					0	0	0.00278	0	0
KRT72	140807	broad.mit.edu	37	12	52994868	52994868	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:52994868G>T	uc001sar.2	-	1	455	c.369C>A	c.(367-369)GCC>GCA	p.A123A	KRT72_uc001saq.2_Silent_p.A123A|KRT72_uc010sns.1_Silent_p.A123A|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	123	Head.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		CCCGCTCCTGGGCGCGCACCC	0.642			NA											13	42					7.03913e-09	1.06427e-08	0.001368	1	0
KRT79	338785	broad.mit.edu	37	12	53215770	53215770	+	Missense_Mutation	SNP	C	C	A	rs141269667		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:53215770C>A	uc001sbb.2	-	9	1527	c.1494G>T	c.(1492-1494)AAG>AAT	p.K498N	KRT79_uc001sba.2_Missense_Mutation_p.K269N	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	498	Tail.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						TGAATCCACCCTTGGTGGCCC	0.622			NA											12	28					4.36969e-10	6.88557e-10	0.001855	1	0
NEUROD4	58158	broad.mit.edu	37	12	55421015	55421015	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:55421015C>G	uc001sgp.3	+	2	1170	c.792C>G	c.(790-792)TCC>TCG	p.S264S		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	264					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						GGAACTTCTCCTTGAAGCAAG	0.512			NA											22	89					0	0	0.002299	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421034	55421034	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:55421034C>A	uc001sgp.3	+	2	1189	c.811C>A	c.(811-813)CCT>ACT	p.P271T		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	271					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						AGATGGGTCTCCTGACCTAGA	0.532			NA											25	100					2.41591e-17	4.33198e-17	0.004656	1	0
PAN2	9924	broad.mit.edu	37	12	56713716	56713716	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:56713716T>A	uc001skx.2	-	21	3263	c.2890A>T	c.(2890-2892)ATG>TTG	p.M964L	PAN2_uc001skw.2_Missense_Mutation_p.M112L|PAN2_uc001skz.2_Missense_Mutation_p.M963L|PAN2_uc001sky.2_Missense_Mutation_p.M960L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	964					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TCATTCAGCATCAGTGGAATA	0.507			NA											10	33					0	0	0.000978	0	0
LRP1	4035	broad.mit.edu	37	12	57569858	57569858	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:57569858G>T	uc001snd.2	+	24	4426	c.3960G>T	c.(3958-3960)AAG>AAT	p.K1320N		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1320	LDL-receptor class B 8.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGAGGACAAGATCTACCGCG	0.657			NA									OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	42					3.86212e-05	4.78167e-05	0.008291	1	0
R3HDM2	22864	broad.mit.edu	37	12	57663634	57663635	+	Missense_Mutation	DNP	CG	CG	GT			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:57663634_57663635CG>GT	uc009zpm.1	-	13	1480_1481	c.1445_1446CG>AC	c.(1444-1446)ACG>AAC	p.T482N	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.T177N|R3HDM2_uc001snr.2_Missense_Mutation_p.T209N|R3HDM2_uc001sns.2_Missense_Mutation_p.T482N|R3HDM2_uc001snt.2_Missense_Mutation_p.T496N|R3HDM2_uc009zpn.1_Missense_Mutation_p.T105N	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	482	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						GGGGCTGACCCGTGGAAGCCAT	0.574			NA											7	25					0	0	0.004672	0	0
AVPR1A	552	broad.mit.edu	37	12	63543872	63543873	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:63543872_63543873CG>AA	uc001sro.1	-	1	2718_2719	c.744_745CG>TT	c.(742-747)CGCGGG>CGTTGG	p.G249W		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	249	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	GCCGTCTTCCCGCGGACGTTGC	0.614			NA											17	93					0	0	0.004672	0	0
DPY19L2	283417	broad.mit.edu	37	12	63976267	63976267	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:63976267G>T	uc001srp.1	-	18	1825	c.1644C>A	c.(1642-1644)GCC>GCA	p.A548A	DPY19L2_uc010sso.1_5'UTR	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	548	Helical; (Potential).				multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AAATGGCAAGGGCAGTAAACA	0.338			NA											8	22					0.00307968	0.0033563	0.00308	1	0
BEST3	144453	broad.mit.edu	37	12	70072552	70072552	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:70072552G>A	uc001svg.2	-	5	830	c.603C>T	c.(601-603)ATC>ATT	p.I201I	BEST3_uc001svd.1_Silent_p.I201I|BEST3_uc001sve.1_RNA|BEST3_uc001svf.2_Silent_p.I39I|BEST3_uc010stm.1_Silent_p.I95I|BEST3_uc001svh.2_Silent_p.I39I	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	201	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CACTGTCTCTGATTCTACCTT	0.373			NA											19	49					0	0	0.002299	0	0
PTPRB	5787	broad.mit.edu	37	12	70948995	70948995	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:70948995G>C	uc001swb.3	-	18	4464	c.4434C>G	c.(4432-4434)TTC>TTG	p.F1478L	PTPRB_uc010sto.1_Missense_Mutation_p.F1388L|PTPRB_uc010stp.1_Missense_Mutation_p.F1388L|PTPRB_uc001swc.3_Missense_Mutation_p.F1696L|PTPRB_uc001swa.3_Missense_Mutation_p.F1608L	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1478	Fibronectin type-III 17.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGGTGTCGCTGAACCAGCTGC	0.473			NA											9	29					0	0	0.006214	0	0
RAB21	23011	broad.mit.edu	37	12	72179334	72179334	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:72179334G>C	uc001swt.2	+	7	811	c.559G>C	c.(559-561)GAT>CAT	p.D187H		NM_014999	NP_055814	Q9UL25	RAB21_HUMAN	RAB21, member RAS oncogene family	187					protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding				0						AGCACAAGTGGATGAGAGAGC	0.428			NA											4	23					0	0	0.009096	0	0
TRHDE	29953	broad.mit.edu	37	12	73056937	73056937	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:73056937G>C	uc001sxa.2	+	19	3067	c.3037G>C	c.(3037-3039)GAG>CAG	p.E1013Q		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1013	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTACCAAGACGAGCTTTTCCA	0.393			NA											8	34					0	0	0.000978	0	0
KCNC2	3747	broad.mit.edu	37	12	75444272	75444272	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:75444272A>T	uc001sxg.1	-	3	2057	c.1513T>A	c.(1513-1515)TCA>ACA	p.S505T	KCNC2_uc009zry.2_Missense_Mutation_p.S505T|KCNC2_uc001sxe.2_Missense_Mutation_p.S505T|KCNC2_uc001sxf.2_Missense_Mutation_p.S505T|KCNC2_uc010stw.1_Missense_Mutation_p.S505T	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	505	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AAAGTAGGTGAGCTTGCCTGA	0.423			NA											22	82					0	0	0.002299	0	0
NAV3	89795	broad.mit.edu	37	12	78515894	78515894	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:78515894C>A	uc001syp.2	+	16	4097	c.3924C>A	c.(3922-3924)AGC>AGA	p.S1308R	NAV3_uc001syo.2_Missense_Mutation_p.S1308R|NAV3_uc010sub.1_Missense_Mutation_p.S808R|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1308	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GCGGCAGCAGCAGCCCTCTCT	0.557			NA								HNSCC(70;0.22)			6	35					0.00307968	0.0033563	0.00308	1	0
NAV3	89795	broad.mit.edu	37	12	78574729	78574729	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:78574729C>A	uc001syp.2	+	30	5769	c.5596C>A	c.(5596-5598)CCG>ACG	p.P1866T	NAV3_uc001syo.2_Missense_Mutation_p.P1844T|NAV3_uc010sub.1_Missense_Mutation_p.P1323T|NAV3_uc009zsf.2_Missense_Mutation_p.P675T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1866						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TACTCGGCCACCGTCAGAATC	0.433			NA								HNSCC(70;0.22)			8	35					0.000274275	0.000319476	0.004482	1	0
NAV3	89795	broad.mit.edu	37	12	78593237	78593237	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:78593237T>C	uc001syp.2	+	37	6814	c.6641T>C	c.(6640-6642)ATA>ACA	p.I2214T	NAV3_uc001syo.2_Missense_Mutation_p.I2192T|NAV3_uc010sub.1_Missense_Mutation_p.I1671T|NAV3_uc009zsf.2_Missense_Mutation_p.I1023T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2214						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GTCAAAATTATAGATTGGATT	0.363			NA								HNSCC(70;0.22)			13	47					0	0	0.00245	0	0
ACSS3	79611	broad.mit.edu	37	12	81532992	81532992	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:81532992A>T	uc001szl.1	+	4	819	c.728A>T	c.(727-729)AAA>ATA	p.K243I	ACSS3_uc001szm.1_Missense_Mutation_p.K242I	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	243						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GAAGCGCTAAAAATAGGACAA	0.353			NA											12	52					0	0	0.000978	0	0
PPFIA2	8499	broad.mit.edu	37	12	81741468	81741468	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:81741468G>T	uc001szo.1	-	18	2237	c.2076C>A	c.(2074-2076)GGC>GGA	p.G692G	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	618										ovary(3)|lung(2)|pancreas(1)	6						CCAAATTCAGGCCTTCGAGGC	0.468			NA											9	60					3.86212e-05	4.78167e-05	0.008291	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85518200	85518200	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:85518200G>T	uc001tac.2	+	17	4021	c.3910G>T	c.(3910-3912)GCA>TCA	p.A1304S	LRRIQ1_uc001tab.1_Missense_Mutation_p.A1304S	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1304										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AGACAGCAAGGCAAGCAGTAT	0.393			NA											28	124					8.58068e-18	1.55198e-17	0.007291	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85546088	85546088	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:85546088G>T	uc001tac.2	+	20	4471	c.4360G>T	c.(4360-4362)GAT>TAT	p.D1454Y		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1454										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GCTAGCATTAGATTCCACCCG	0.378			NA											13	65					1.3612e-06	1.85225e-06	0.003163	1	0
CEP290	80184	broad.mit.edu	37	12	88465670	88465670	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:88465670C>A	uc001tar.2	-	42	6087	c.5743G>T	c.(5743-5745)GGT>TGT	p.G1915C	CEP290_uc001taq.2_Missense_Mutation_p.G975C	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1915	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						CACTTTTTACCTTCTTCCCAC	0.318			NA											5	10					1.23904e-05	1.57558e-05	0.000602	1	0
USP44	84101	broad.mit.edu	37	12	95914840	95914840	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:95914840C>A	uc001teg.2	-	5	2016	c.1872G>T	c.(1870-1872)GTG>GTT	p.V624V	USP44_uc001teh.2_Silent_p.V624V|USP44_uc009zte.2_Silent_p.V621V	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	624					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						GGTGCATCACCACCGCGGACA	0.443			NA											11	64					1.58986e-06	2.14735e-06	0.008291	1	0
SLC25A3	5250	broad.mit.edu	37	12	98987861	98987861	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:98987861G>A	uc001tfo.2	+	2	225	c.105G>A	c.(103-105)GGG>GGA	p.G35G	SLC25A3_uc001tfm.2_Silent_p.G35G|SLC25A3_uc001tfn.2_Silent_p.G35G|SLC25A3_uc001tfp.2_Silent_p.G35G|SLC25A3_uc001tfq.2_5'UTR|SLC25A3_uc001tfr.2_Silent_p.G35G|SLC25A3_uc001tfs.2_5'UTR|SLC25A3_uc009ztn.2_Silent_p.G35G|SLC25A3_uc001tft.2_Silent_p.G35G	NM_005888	NP_005879	Q00325	MPCP_HUMAN	solute carrier family 25 member 3 isoform a	35					generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		GCTCCCCAGGGCCCACGGGCC	0.692			NA											3	15					0	0	0.009096	0	0
SLC5A8	160728	broad.mit.edu	37	12	101587480	101587480	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:101587480T>C	uc001thz.3	-	5	1005	c.615A>G	c.(613-615)ATA>ATG	p.I205M		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	205	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CCACAGCCTGTATAATCACGG	0.408	GBM(60;420 1056 13605 22380 47675)		NA											20	83					0	0	0.010504	0	0
MYBPC1	4604	broad.mit.edu	37	12	102067343	102067343	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:102067343C>A	uc001tii.2	+	24	2833	c.2731C>A	c.(2731-2733)CTG>ATG	p.L911M	MYBPC1_uc001tig.2_Missense_Mutation_p.L918M|MYBPC1_uc010svq.1_Missense_Mutation_p.L880M|MYBPC1_uc001tih.2_Missense_Mutation_p.L918M|MYBPC1_uc001tij.2_Missense_Mutation_p.L893M|MYBPC1_uc010svr.1_Missense_Mutation_p.L893M|MYBPC1_uc010svs.1_Missense_Mutation_p.L911M|MYBPC1_uc010svt.1_Missense_Mutation_p.L881M|MYBPC1_uc010svu.1_Missense_Mutation_p.L874M|MYBPC1_uc001tik.2_Missense_Mutation_p.L867M|MYBPC1_uc001til.2_Translation_Start_Site|MYBPC1_uc001tim.2_Translation_Start_Site	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	911	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GAAATATGATCTGCAAGTCAA	0.388			NA											26	124					4.59853e-10	7.23833e-10	0.005443	1	0
MYBPC1	4604	broad.mit.edu	37	12	102071040	102071040	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:102071040C>A	uc001tii.2	+	26	3058	c.2956C>A	c.(2956-2958)CAT>AAT	p.H986N	MYBPC1_uc001tig.2_Missense_Mutation_p.H993N|MYBPC1_uc010svq.1_Missense_Mutation_p.H955N|MYBPC1_uc001tih.2_Missense_Mutation_p.H993N|MYBPC1_uc001tij.2_Missense_Mutation_p.H968N|MYBPC1_uc010svr.1_Missense_Mutation_p.H968N|MYBPC1_uc010svs.1_Missense_Mutation_p.H986N|MYBPC1_uc010svt.1_Missense_Mutation_p.H956N|MYBPC1_uc010svu.1_Missense_Mutation_p.H949N|MYBPC1_uc001tik.2_Missense_Mutation_p.H942N|MYBPC1_uc001til.2_Missense_Mutation_p.H11N|MYBPC1_uc001tim.2_Missense_Mutation_p.H11N	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	986	Fibronectin type-III 3.			YHRTSATI -> IIEPVPH (in Ref. 1; CAA46987).	cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TGAGCATTATCATCGAACCAG	0.368			NA											13	63					2.68362e-12	4.45536e-12	0.001368	1	0
STAB2	55576	broad.mit.edu	37	12	104136306	104136306	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:104136306C>A	uc001tjw.2	+	56	6191	c.6005C>A	c.(6004-6006)CCG>CAG	p.P2002Q	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2002	Extracellular (Potential).|Laminin EGF-like 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ATGTGCTGGCCGGGGAGATTC	0.562			NA											21	76					1.85244e-09	2.87237e-09	0.00333	1	0
POLR3B	55703	broad.mit.edu	37	12	106760300	106760300	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:106760300G>T	uc001tlp.2	+	3	334	c.112G>T	c.(112-114)GGC>TGC	p.G38C	POLR3B_uc001tlq.2_Translation_Start_Site	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	38					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTAGGTGAAAGGCCTTGTGAA	0.308			NA											4	16					0.000602214	0.000682885	0.000602	1	0
POLR3B	55703	broad.mit.edu	37	12	106895214	106895214	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:106895214G>C	uc001tlp.2	+	26	3320	c.3098G>C	c.(3097-3099)AGG>ACG	p.R1033T	POLR3B_uc001tlq.2_Missense_Mutation_p.R975T	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	1033					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						GTCCTTACCAGGTAAGAGAAA	0.438			NA											6	20					0	0	0.001168	0	0
BTBD11	121551	broad.mit.edu	37	12	108012033	108012033	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:108012033C>G	uc001tmk.1	+	10	2851	c.2330C>G	c.(2329-2331)ACA>AGA	p.T777R	BTBD11_uc009zut.1_Intron|BTBD11_uc001tmj.2_Missense_Mutation_p.T777R|BTBD11_uc001tml.1_Missense_Mutation_p.T314R	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	777						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CTGGCGGAGACAGCCCCGCCC	0.617			NA											5	21					0	0	0.001168	0	0
PRDM4	11108	broad.mit.edu	37	12	108145650	108145650	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:108145650G>A	uc001tmp.2	-	5	1105	c.668C>T	c.(667-669)TCC>TTC	p.S223F	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	223					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TGGGATTTGGGAATGCTCGCC	0.507			NA											6	38					0	0	0.001168	0	0
SART3	9733	broad.mit.edu	37	12	108936916	108936916	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:108936916G>T	uc001tmz.1	-	6	1029	c.794C>A	c.(793-795)ACA>AAA	p.T265K	SART3_uc001tmy.1_5'Flank|SART3_uc009zux.1_5'UTR|SART3_uc010swx.1_Missense_Mutation_p.T265K|SART3_uc010swy.1_Missense_Mutation_p.T151K|SART3_uc010swz.1_Missense_Mutation_p.T265K|SART3_uc001tna.1_RNA	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	265	HAT 4.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						CTCTGCAAATGTGGCCTCCAT	0.418			NA							Porokeratosis				9	44					0.000673444	0.000757755	0.008291	1	0
FOXN4	121643	broad.mit.edu	37	12	109723261	109723261	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:109723261C>A	uc001toe.3	-	8	854	c.749G>T	c.(748-750)TGC>TTC	p.C250F	FOXN4_uc009zvg.2_Missense_Mutation_p.C47F|FOXN4_uc001tof.3_Missense_Mutation_p.C70F	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	250	Fork-head.				axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						CTTCTCGAAGCACTTGTTCAG	0.597			NA											5	30					8.12818e-05	9.82943e-05	0.001984	1	0
C12orf51	283450	broad.mit.edu	37	12	112654893	112654893	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:112654893C>A	uc009zwc.2	-	39	5933	c.5915G>T	c.(5914-5916)GGG>GTG	p.G1972V	C12orf51_uc001ttr.1_Missense_Mutation_p.G147V	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CAGGCCTCCCCCAGCGCTGGG	0.547			NA											3	18					0.004672	0.00503511	0.004672	1	0
RPH3A	22895	broad.mit.edu	37	12	113314541	113314541	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:113314541C>G	uc010syl.1	+	13	1403	c.1041C>G	c.(1039-1041)GAC>GAG	p.D347E	RPH3A_uc001ttz.2_Missense_Mutation_p.D347E|RPH3A_uc001tty.2_Missense_Mutation_p.D343E|RPH3A_uc009zwe.1_Missense_Mutation_p.D343E|RPH3A_uc010sym.1_Missense_Mutation_p.D298E|RPH3A_uc001tua.2_Missense_Mutation_p.D107E	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	347	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CCAGAGAGGACCGAATGAGCC	0.682			NA											6	41					0	0	0.001168	0	0
OAS3	4940	broad.mit.edu	37	12	113400594	113400594	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:113400594G>T	uc001tug.2	+	9	2058	c.1971G>T	c.(1969-1971)ACG>ACT	p.T657T		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	657	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GCTTCCGGACGGTGCTGGGGC	0.597			NA											17	78					3.6726e-16	6.52111e-16	0.003954	1	0
TAOK3	51347	broad.mit.edu	37	12	118598074	118598074	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:118598074T>C	uc001twx.2	-	19	2524	c.2229A>G	c.(2227-2229)GAA>GAG	p.E743E	TAOK3_uc001twv.2_Silent_p.E283E|TAOK3_uc001tww.2_Silent_p.E573E|TAOK3_uc001twy.3_Silent_p.E743E	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	743					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTGGAGTAACTTCCAACTGGT	0.378			NA											25	120					0	0	0.004656	0	0
P2RX4	5025	broad.mit.edu	37	12	121660769	121660769	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:121660769C>T	uc001tzr.2	+	5	751	c.447C>T	c.(445-447)TGC>TGT	p.C149C	P2RX4_uc010szr.1_Intron|P2RX4_uc010szs.1_Intron|P2RX4_uc009zxc.2_Intron|P2RX4_uc001tzs.2_Silent_p.C165C|P2RX4_uc009zxb.2_RNA|P2RX4_uc010szt.1_Silent_p.C48C	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4	149	Extracellular (Potential).				endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAGGCAGGTGCGTAGCTTTCA	0.582			NA											4	21					0	0	0.009096	0	0
VPS33A	65082	broad.mit.edu	37	12	122723133	122723133	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:122723133C>A	uc001ucd.2	-	10	1415	c.1302_splice	c.e10+1	p.Q434_splice	VPS33A_uc001ucc.2_Splice_Site	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A						lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		aatataCTCACCTGGAGAATC	0.284			NA											9	64					5.4927e-09	8.34799e-09	0.004482	1	0
RSRC2	65117	broad.mit.edu	37	12	122991382	122991382	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:122991382T>A	uc001ucr.2	-	9	1270	c.1124A>T	c.(1123-1125)AAG>ATG	p.K375M	RSRC2_uc001uco.2_Missense_Mutation_p.K144M|RSRC2_uc001ucp.2_Missense_Mutation_p.K316M|RSRC2_uc001ucq.2_Missense_Mutation_p.K143M|RSRC2_uc001ucs.2_Missense_Mutation_p.K144M|RSRC2_uc001uct.2_Missense_Mutation_p.K327M|RSRC2_uc001ucu.2_Missense_Mutation_p.K376M	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	375										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		GAAACTCACCTTAATACCCAT	0.274			NA											19	77					0	0	0.001882	0	0
NCOR2	9612	broad.mit.edu	37	12	124826399	124826399	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:124826399G>A	uc010tba.1	-	34	5299	c.5182C>T	c.(5182-5184)CTG>TTG	p.L1728L	NCOR2_uc010tay.1_Silent_p.L1727L|NCOR2_uc010taz.1_Silent_p.L1711L|NCOR2_uc010tbb.1_Silent_p.L1720L|NCOR2_uc010tbc.1_Silent_p.L1710L|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1728					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTGAGTGCCAGCGAGGACTCG	0.647			NA											12	57					0	0	0.003163	0	0
TMEM132D	121256	broad.mit.edu	37	12	129566543	129566543	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:129566543C>A	uc009zyl.1	-	7	2012	c.1684G>T	c.(1684-1686)GAG>TAG	p.E562*	TMEM132D_uc001uia.2_Nonsense_Mutation_p.E100*	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	562	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCCCTCCGCTCATCATCCTCC	0.642			NA											10	49					4.68919e-08	6.87559e-08	0.008291	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184738	130184738	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:130184738C>A	uc009zyl.1	-	2	913	c.585G>T	c.(583-585)GAG>GAT	p.E195D		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	195	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGAGCTCCAGCTCGGCCACGC	0.692			NA											9	26					3.86212e-05	4.78167e-05	0.008291	1	0
EP400	57634	broad.mit.edu	37	12	132522603	132522603	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:132522603G>T	uc001ujn.2	+	31	6204	c.6169G>T	c.(6169-6171)GAA>TAA	p.E2057*	EP400_uc001ujl.2_Nonsense_Mutation_p.E2056*|EP400_uc001ujm.2_Nonsense_Mutation_p.E1976*	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2093					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTCTGTCACGGAAACCATTGC	0.498			NA											15	84					2.32078e-09	3.57952e-09	0.003163	1	0
NOC4L	79050	broad.mit.edu	37	12	132630208	132630208	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:132630208A>C	uc001ujz.1	+	3	384	c.343A>C	c.(343-345)AAG>CAG	p.K115Q	DDX51_uc001ujy.3_5'Flank	NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	115					rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		CTTTCAGGTCAAGGTGGGTCA	0.592			NA											3	13					0	0	0.004672	0	0
GOLGA3	2802	broad.mit.edu	37	12	133373168	133373168	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:133373168C>A	uc001ukz.1	-	10	2616	c.2057G>T	c.(2056-2058)AGG>ATG	p.R686M	GOLGA3_uc001ula.1_Missense_Mutation_p.R686M|GOLGA3_uc001ulb.2_Missense_Mutation_p.R686M	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	686	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GTCCGCCATCCTCTGCAGCCG	0.622			NA											28	112					5.45727e-16	9.67818e-16	0.008361	1	0
TUBA3C	7278	broad.mit.edu	37	13	19751540	19751540	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:19751540G>T	uc009zzj.2	-	4	632	c.583C>A	c.(583-585)CTG>ATG	p.L195M		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	195					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAATGTTCCAGGGTCGTGTGG	0.557			NA											13	79					0.000151284	0.000181292	0.001855	1	0
FAM123A	219287	broad.mit.edu	37	13	25745661	25745661	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:25745661C>T	uc001uqb.2	-	1	197	c.97G>A	c.(97-99)GGG>AGG	p.G33R	FAM123A_uc001uqa.2_Missense_Mutation_p.G33R|FAM123A_uc001uqc.2_Missense_Mutation_p.G33R	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	33	Gly-rich.									ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GTCCCGGCCCCGGCCTCCGCC	0.721			NA											3	5					0	0	0.000602	0	0
FLT1	2321	broad.mit.edu	37	13	28893581	28893581	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:28893581G>A	uc001usb.3	-	24	3550	c.3265C>T	c.(3265-3267)CTG>TTG	p.L1089L	FLT1_uc010aap.2_Silent_p.L94L|FLT1_uc010aaq.2_Silent_p.L214L|FLT1_uc001usa.3_Silent_p.L307L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1089	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ATTTCCCACAGCAATACTCCG	0.433			NA											4	7					0	0	0.009096	0	0
USPL1	10208	broad.mit.edu	37	13	31221131	31221131	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:31221131C>G	uc001utc.2	+	7	1607	c.1175C>G	c.(1174-1176)GCC>GGC	p.A392G	USPL1_uc001utb.2_Missense_Mutation_p.A211G|USPL1_uc001utd.2_Missense_Mutation_p.A63G|USPL1_uc001ute.1_Missense_Mutation_p.A63G	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	392					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		CTTAATGCTGCCCATTTTGGT	0.308	Ovarian(60;318 1180 1554 28110 31601)		NA											17	32					0	0	0.006122	0	0
POSTN	10631	broad.mit.edu	37	13	38160919	38160919	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:38160919T>A	uc001uwo.3	-	6	871	c.753A>T	c.(751-753)AGA>AGT	p.R251S	POSTN_uc001uwp.3_Missense_Mutation_p.R251S|POSTN_uc001uwr.2_Missense_Mutation_p.R251S|POSTN_uc001uwq.2_Missense_Mutation_p.R251S|POSTN_uc010teu.1_Missense_Mutation_p.R251S|POSTN_uc010tev.1_Missense_Mutation_p.R251S|POSTN_uc010tew.1_Missense_Mutation_p.R251S|POSTN_uc010tex.1_Missense_Mutation_p.R166S	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	251	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTGGACTTACTCTAAAAGATG	0.358			NA											8	24					0	0	0.008291	0	0
THSD1	55901	broad.mit.edu	37	13	52960290	52960290	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:52960290C>A	uc001vgo.2	-	4	1598	c.1053G>T	c.(1051-1053)CAG>CAT	p.Q351H	THSD1_uc001vgp.2_Intron|THSD1_uc010tgz.1_5'UTR|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	351	Extracellular (Potential).|TSP type-1.					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		TGGCACTACACTGGCTCCATG	0.502			NA											13	44					9.31168e-06	1.20836e-05	0.001855	1	0
OXGR1	27199	broad.mit.edu	37	13	97639466	97639466	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:97639466C>A	uc001vmx.1	-	4	792	c.548G>T	c.(547-549)TGT>TTT	p.C183F	OXGR1_uc010afr.1_Missense_Mutation_p.C183F	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	183	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			GAGGTCGAGACAGGCTGATCT	0.468			NA											8	25					0.000157383	0.000187214	0.00308	1	0
OXGR1	27199	broad.mit.edu	37	13	97639828	97639828	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr13:97639828C>G	uc001vmx.1	-	4	430	c.186G>C	c.(184-186)ATG>ATC	p.M62I	OXGR1_uc010afr.1_Missense_Mutation_p.M62I	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	62	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TCCAAGGTCTCATTTTGAAAA	0.468			NA											5	5					0	0	0.000602	0	0
OR4K5	79317	broad.mit.edu	37	14	20389047	20389047	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:20389047C>A	uc010tkw.1	+	1	282	c.282C>A	c.(280-282)TTC>TTA	p.F94L		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCATATCTTTCAGTGGCTGCA	0.423			NA											15	267					1.3612e-06	1.85225e-06	0.003163	1	0
TEP1	7011	broad.mit.edu	37	14	20864809	20864809	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:20864809C>T	uc001vxe.2	-	10	1670	c.1630G>A	c.(1630-1632)GAG>AAG	p.E544K	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.E436K	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	544	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGAATGAGCTCATGGTGGCGG	0.567			NA											3	8					0	0	0.004672	0	0
JUB	84962	broad.mit.edu	37	14	23450581	23450581	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:23450581C>A	uc001whz.2	-	1	1271	c.895G>T	c.(895-897)GGA>TGA	p.G299*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	299	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GAGGGTTCTCCGCGGGCTCCG	0.716	Esophageal Squamous(134;328 1721 9795 37986 41605)		NA											6	19					8.12818e-05	9.82943e-05	0.001984	1	0
MYH6	4624	broad.mit.edu	37	14	23856749	23856749	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:23856749C>G	uc001wjv.2	-	32	4706	c.4639G>C	c.(4639-4641)GAG>CAG	p.E1547Q		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1547	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCTGCCTCCTCCAGGGCTGAC	0.612			NA											8	28					0	0	0.00308	0	0
IPO4	79711	broad.mit.edu	37	14	24656934	24656934	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:24656934C>A	uc001wmv.1	-	5	478	c.347G>T	c.(346-348)TGG>TTG	p.W116L	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_5'UTR|IPO4_uc001wmy.1_5'UTR|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.W116L	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	116					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		AAGCTGTGGCCAGGCCTCCAA	0.592			NA											14	53					7.93312e-07	1.09071e-06	0.00245	1	0
NYNRIN	57523	broad.mit.edu	37	14	24884157	24884157	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:24884157C>T	uc001wpf.3	+	9	3520	c.3202C>T	c.(3202-3204)CCC>TCC	p.P1068S		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1068					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CCTGGGCATCCCCTGGGATGG	0.627			NA											7	53					0	0	0.001984	0	0
NOVA1	4857	broad.mit.edu	37	14	26918030	26918030	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:26918030A>G	uc001wpy.2	-	5	977	c.659T>C	c.(658-660)GTT>GCT	p.V220A	NOVA1_uc001wpz.2_Missense_Mutation_p.V196A|NOVA1_uc001wqa.2_Missense_Mutation_p.V98A	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	223	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CACAGTGACAACCCTCTCTTG	0.483			NA											12	87					0	0	0.003163	0	0
MBIP	51562	broad.mit.edu	37	14	36789785	36789785	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:36789785C>A	uc001wtm.2	-	1	98	c.10G>T	c.(10-12)GCC>TCC	p.A4S	MBIP_uc001wto.2_Missense_Mutation_p.A4S|MBIP_uc010tpy.1_5'UTR|MBIP_uc001wtn.2_Missense_Mutation_p.A4S	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	4					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		AGCTCCGTGGCAGCAGCCATG	0.592			NA											4	26					5.18039e-06	6.82593e-06	0.00308	1	0
FBXO33	254170	broad.mit.edu	37	14	39870665	39870665	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:39870665G>T	uc001wvk.2	-	3	1449	c.1111C>A	c.(1111-1113)CGG>AGG	p.R371R		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	F-box protein 33	371											0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		ATATAGACCCGAAAGCTGGTG	0.398			NA											11	44					7.03913e-09	1.06427e-08	0.001368	1	0
LRFN5	145581	broad.mit.edu	37	14	42356335	42356335	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:42356335G>A	uc001wvm.2	+	3	1705	c.507G>A	c.(505-507)AAG>AAA	p.K169K	LRFN5_uc010ana.2_Silent_p.K169K	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	169	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTGTTGAGAAGATGGTTAGCT	0.418			NA								HNSCC(30;0.082)			4	48					0	0	0.009096	0	0
FSCB	84075	broad.mit.edu	37	14	44973781	44973781	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:44973781G>T	uc001wvn.2	-	1	2719	c.2410C>A	c.(2410-2412)CAG>AAG	p.Q804K		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	804						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GTGGGAGCCTGTCCATCATTG	0.358			NA											8	58					0.000157383	0.000187214	0.00308	1	0
FSCB	84075	broad.mit.edu	37	14	44975604	44975604	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:44975604G>A	uc001wvn.2	-	1	896	c.587C>T	c.(586-588)CCT>CTT	p.P196L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	196						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TTGAAATTCAGGGTGTTCACT	0.398			NA											22	102					0	0	0.001882	0	0
FAM179B	23116	broad.mit.edu	37	14	45432037	45432037	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:45432037G>C	uc001wvv.2	+	1	622	c.413G>C	c.(412-414)CGG>CCG	p.R138P	FAM179B_uc001wvw.2_Missense_Mutation_p.R138P|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R138P|FAM179B_uc001wvu.2_Missense_Mutation_p.R138P	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	138							binding			skin(2)|upper_aerodigestive_tract(1)	3						GCTTTGTATCGGGCACTGGGC	0.632			NA											27	77					0	0	0.007291	0	0
MUDENG	55745	broad.mit.edu	37	14	57749878	57749878	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:57749878C>A	uc001xcv.2	+	6	1650	c.1223C>A	c.(1222-1224)ACT>AAT	p.T408N	MUDENG_uc010tri.1_Missense_Mutation_p.T162N|MUDENG_uc010trj.1_Missense_Mutation_p.T305N	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	408	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						GGAACTGTAACTTTTGGAGCC	0.343			NA											10	52					3.86212e-05	4.78167e-05	0.008291	1	0
DACT1	51339	broad.mit.edu	37	14	59112625	59112625	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:59112625C>T	uc001xdw.2	+	4	1448	c.1284C>T	c.(1282-1284)GCC>GCT	p.A428A	DACT1_uc010trv.1_Silent_p.A147A|DACT1_uc001xdx.2_Silent_p.A391A|DACT1_uc010trw.1_Silent_p.A147A	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	428					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCGAACAAGCCGAAAGCAAGA	0.597			NA											6	29					0	0	0.001984	0	0
DAAM1	23002	broad.mit.edu	37	14	59757934	59757934	+	Splice_Site	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:59757934G>T	uc001xdz.1	+	3	309	c.184_splice	c.e3-1	p.D62_splice	DAAM1_uc001xea.1_Splice_Site_p.D62_splice|DAAM1_uc001xeb.1_Splice_Site_p.D62_splice	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of						actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TTTCTTCTCAGGATGAACTGG	0.338			NA											8	13					1.06961e-07	1.54041e-07	0.00308	1	0
SYT16	83851	broad.mit.edu	37	14	62536500	62536500	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:62536500G>A	uc001xfu.1	+	2	900	c.703G>A	c.(703-705)GGA>AGA	p.G235R	SYT16_uc010tsd.1_Missense_Mutation_p.G235R	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	235										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GTTGACACACGGAGAAGATGG	0.488			NA											6	35					0	0	0.001984	0	0
SYNE2	23224	broad.mit.edu	37	14	64518958	64518958	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:64518958T>C	uc001xgm.2	+	48	8557	c.8327T>C	c.(8326-8328)CTA>CCA	p.L2776P	SYNE2_uc001xgl.2_Missense_Mutation_p.L2776P	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2776	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GATGGCATTCTAGCTAGGCAG	0.443			NA											19	90					0	0	0.006122	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65210038	65210038	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:65210038G>C	uc001xho.1	+	17	3546	c.3277G>C	c.(3277-3279)GGC>CGC	p.G1093R	PLEKHG3_uc001xhn.1_Missense_Mutation_p.G1037R|PLEKHG3_uc001xhp.2_Missense_Mutation_p.G1214R|PLEKHG3_uc010aqh.1_Missense_Mutation_p.G635R|PLEKHG3_uc001xhq.1_Missense_Mutation_p.G598R	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	1093					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		ACCTCTGTCGGGCAGGGTGGG	0.622			NA											5	17					0	0	0.001168	0	0
RGS6	9628	broad.mit.edu	37	14	72939587	72939587	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:72939587C>A	uc001xna.3	+	9	1067	c.544C>A	c.(544-546)CGG>AGG	p.R182R	RGS6_uc010ttn.1_Silent_p.R182R|RGS6_uc001xmx.3_Silent_p.R182R|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Silent_p.R182R|RGS6_uc010ttp.1_Silent_p.R113R|RGS6_uc001xmz.1_Silent_p.R43R|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	182					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAGGATTGACCGGAAAAAAGA	0.448	Ovarian(143;1926 2468 21071 48641)		NA											11	106					5.50884e-06	7.18716e-06	0.001368	1	0
ACOT6	641372	broad.mit.edu	37	14	74086211	74086211	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:74086211G>C	uc001xop.2	+	2	623	c.292G>C	c.(292-294)GAA>CAA	p.E98Q		NM_001037162	NP_001032239	Q3I5F7	ACOT6_HUMAN	acyl-CoA thioesterase 6	98						cytosol	carboxylesterase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		TGTTCCATTGGAAAAGGCGCA	0.423			NA											12	68					0	0	0.000978	0	0
KCNK13	56659	broad.mit.edu	37	14	90650807	90650807	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:90650807C>A	uc001xye.1	+	2	1129	c.687C>A	c.(685-687)TAC>TAA	p.Y229*		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	229						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				ACTCACTCTACTTCTGTTTTG	0.537			NA											9	63					0.00621372	0.00666704	0.006214	1	0
C14orf49	161176	broad.mit.edu	37	14	95912351	95912351	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:95912351G>T	uc001yei.3	-	8	1542	c.1527C>A	c.(1525-1527)ATC>ATA	p.I509I	C14orf49_uc010avi.2_Silent_p.I509I|C14orf49_uc001yej.1_Silent_p.I509I	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	509	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CCTGGCCAAAGATGCCAATCA	0.577			NA											25	66					3.08376e-08	4.56297e-08	0.00333	1	0
CYP46A1	10858	broad.mit.edu	37	14	100182205	100182205	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:100182205G>T	uc001ygo.2	+	8	752	c.752G>T	c.(751-753)CGC>CTC	p.R251L	CYP46A1_uc001ygp.2_Missense_Mutation_p.R98L	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	251					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CGCTTCCTGCGCCAGGTGGGC	0.612			NA											4	30					0.00909568	0.00969496	0.009096	1	0
C14orf68	283600	broad.mit.edu	37	14	100795129	100795129	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:100795129C>G	uc001yhc.2	+	5	467	c.394C>G	c.(394-396)CAG>GAG	p.Q132E	C14orf68_uc001yhd.2_5'UTR	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	132	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				GGCGCAGAAGCAGCAGCGGCG	0.672			NA											4	25					0	0	0.009096	0	0
CINP	51550	broad.mit.edu	37	14	102825902	102825902	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:102825902C>A	uc001ylv.1	-	2	95	c.30G>T	c.(28-30)ACG>ACT	p.T10T	CINP_uc001ylu.1_RNA	NM_032630	NP_116019	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2-interacting protein	10					cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(1)	1						GTTTTCTGGGCGTTACAGTTC	0.373			NA											10	61					3.03607e-14	5.20061e-14	0.001368	1	0
GPR132	29933	broad.mit.edu	37	14	105518256	105518256	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr14:105518256T>A	uc001yqd.2	-	4	1117	c.218A>T	c.(217-219)CAG>CTG	p.Q73L	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Missense_Mutation_p.Q64L	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	73	Cytoplasmic (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		CACGTTGCCCTGCAGTACCTG	0.642			NA											14	53					0	0	0.003163	0	0
C15orf2	23742	broad.mit.edu	37	15	24921212	24921212	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:24921212C>A	uc001ywo.2	+	1	672	c.198C>A	c.(196-198)GTC>GTA	p.V66V		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	66					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCATCTTCGTCGCCCCTAAGA	0.721			NA											10	18					6.40141e-05	7.85211e-05	0.000978	1	0
C15orf2	23742	broad.mit.edu	37	15	24923342	24923342	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:24923342C>A	uc001ywo.2	+	1	2802	c.2328C>A	c.(2326-2328)GCC>GCA	p.A776A		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	776					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AATTTGGGGCCCCTGATGGGC	0.552			NA											40	104					8.20599e-20	1.51623e-19	0.002852	1	0
C15orf2	23742	broad.mit.edu	37	15	24924327	24924327	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:24924327G>A	uc001ywo.2	+	1	3787	c.3313G>A	c.(3313-3315)GAT>AAT	p.D1105N		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1105					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TATGGGAGGGGATGGCACCAG	0.493			NA											38	65					0	0	0.003755	0	0
HERC2	8924	broad.mit.edu	37	15	28463681	28463681	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:28463681G>A	uc001zbj.2	-	38	6088	c.5982C>T	c.(5980-5982)TGC>TGT	p.C1994C		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1994					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCAGCAGTCCGCATAAAGTCT	0.517			NA											4	95					0	0	0.009096	0	0
RYR3	6263	broad.mit.edu	37	15	33916196	33916196	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:33916196T>C	uc001zhi.2	+	20	2616	c.2546T>C	c.(2545-2547)TTC>TCC	p.F849S	RYR3_uc010bar.2_Missense_Mutation_p.F849S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	849	4 X approximate repeats.|1.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAAGCCTCTTTCATCCCATGC	0.438			NA											43	59					0	0	0.00361	0	0
RYR3	6263	broad.mit.edu	37	15	33925287	33925287	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:33925287G>A	uc001zhi.2	+	24	3075	c.3005G>A	c.(3004-3006)GGA>GAA	p.G1002E	RYR3_uc010bar.2_Missense_Mutation_p.G1002E	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1002	2.|4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATAAAACAAGGATGGACCTAT	0.413			NA											12	24					0	0	0.001855	0	0
RYR3	6263	broad.mit.edu	37	15	33991970	33991970	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:33991970G>C	uc001zhi.2	+	41	6385	c.6315G>C	c.(6313-6315)CGG>CGC	p.R2105R	RYR3_uc010bar.2_Silent_p.R2105R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2105	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAATTAGCCGGCAAAATCAGA	0.433			NA											8	15					0	0	0.004482	0	0
RYR3	6263	broad.mit.edu	37	15	34115218	34115218	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:34115218G>C	uc001zhi.2	+	81	11087	c.11017G>C	c.(11017-11019)GAG>CAG	p.E3673Q	RYR3_uc010bar.2_Missense_Mutation_p.E3668Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3673					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTACCTAAAGGAGAAAAAGGA	0.423			NA											18	24					0	0	0.010504	0	0
ACTC1	70	broad.mit.edu	37	15	35083397	35083397	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:35083397C>A	uc001ziu.1	-	6	1151	c.908G>T	c.(907-909)GGA>GTA	p.G303V	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	303					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AGTGGTGCCTCCAGATAAGAC	0.438			NA											42	85					1.57019e-19	2.88662e-19	0.007835	1	0
BUB1B	701	broad.mit.edu	37	15	40462321	40462321	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:40462321A>T	uc001zkx.3	+	3	450	c.238A>T	c.(238-240)AGG>TGG	p.R80W		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	80	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TGTTTGGGATAGGTGGGTCTT	0.363			NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				25	40					0	0	0.005443	0	0
UBR1	197131	broad.mit.edu	37	15	43348568	43348568	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:43348568C>A	uc001zqq.2	-	11	1321	c.1255G>T	c.(1255-1257)GTT>TTT	p.V419F	UBR1_uc010udk.1_Missense_Mutation_p.V419F	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	419					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AACATCTGAACTGAAAGTGCA	0.294			NA											40	34					5.44703e-19	9.97594e-19	0.009718	1	0
MYEF2	50804	broad.mit.edu	37	15	48441490	48441490	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:48441490C>T	uc001zwi.3	-	15	1581	c.1457G>A	c.(1456-1458)AGA>AAA	p.R486K	MYEF2_uc001zwg.3_Missense_Mutation_p.R24K|MYEF2_uc001zwh.3_Missense_Mutation_p.R74K|MYEF2_uc001zwj.3_Missense_Mutation_p.R462K	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	486	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TGGTCCCATTCTATCAAAGCT	0.493			NA											23	42					0	0	0.003954	0	0
SLC12A1	6557	broad.mit.edu	37	15	48566838	48566838	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:48566838C>A	uc001zwn.3	+	20	2689	c.2473C>A	c.(2473-2475)CTT>ATT	p.L825I	SLC12A1_uc010uew.1_Missense_Mutation_p.L631I|SLC12A1_uc001zwq.3_Missense_Mutation_p.L596I|SLC12A1_uc001zwr.3_Missense_Mutation_p.L552I	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	825	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CTCTCAGGTTCTTCAGGTGCA	0.264			NA											9	12					5.4927e-09	8.34799e-09	0.004482	1	0
HDC	3067	broad.mit.edu	37	15	50534961	50534961	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:50534961C>T	uc001zxz.2	-	12	1591	c.1485G>A	c.(1483-1485)AGG>AGA	p.R495R	HDC_uc001zxy.2_Silent_p.R238R|HDC_uc010uff.1_Silent_p.R462R	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	495					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CTCTGGCACCCCTGATTTGGG	0.577	GBM(95;1627 1936 6910 9570)		NA											10	30					0	0	0.008291	0	0
UNC13C	440279	broad.mit.edu	37	15	54306940	54306940	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:54306940C>G	uc002ack.2	+	1	1840	c.1840C>G	c.(1840-1842)CAA>GAA	p.Q614E		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	614					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCAGGGTATCCAAGGGCAGAC	0.493			NA											25	38					0	0	0.005443	0	0
TLN2	83660	broad.mit.edu	37	15	63063229	63063229	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:63063229C>G	uc002alb.3	+	39	5263	c.5263C>G	c.(5263-5265)CTT>GTT	p.L1755V	TLN2_uc002alc.3_Missense_Mutation_p.L148V|TLN2_uc002ald.2_Missense_Mutation_p.L148V	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1755					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CTCCAAGATTCTTGATCATCA	0.478			NA											21	47					0	0	0.00278	0	0
IGDCC4	57722	broad.mit.edu	37	15	65682616	65682616	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:65682616C>G	uc002aou.1	-	13	2495	c.2285G>C	c.(2284-2286)AGC>ACC	p.S762T	IGDCC4_uc002aot.1_Missense_Mutation_p.S350T	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	762	Fibronectin type-III 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGATGTGGAGCTGTTTGATTC	0.552			NA											11	25					0	0	0.000978	0	0
RPL4	6124	broad.mit.edu	37	15	66792653	66792653	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:66792653G>T	uc002apv.2	-	8	951	c.895C>A	c.(895-897)CAA>AAA	p.Q299K	SNAPC5_uc002apu.1_5'Flank|RPL4_uc010bhr.2_Missense_Mutation_p.Q205K|RPL4_uc002apw.2_Missense_Mutation_p.Q205K|RPL4_uc002apx.2_Missense_Mutation_p.Q205K	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	299					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						AGGGCTCTTTGGATCTCTGGG	0.378			NA											25	46					3.7963e-18	6.90065e-18	0.00333	1	0
CORO2B	10391	broad.mit.edu	37	15	69011535	69011535	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:69011535C>A	uc002arj.3	+	10	1162	c.1133C>A	c.(1132-1134)GCA>GAA	p.A378E	CORO2B_uc010bic.2_Missense_Mutation_p.A373E|CORO2B_uc002ark.2_Missense_Mutation_p.A145E	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	378					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						ACGGAGCCAGCACTGACCCCG	0.607			NA											18	31					1.15919e-05	1.48965e-05	0.008871	1	0
CCDC33	80125	broad.mit.edu	37	15	74623568	74623568	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:74623568C>T	uc002axo.2	+	15	2096	c.1702C>T	c.(1702-1704)CTG>TTG	p.L568L	CCDC33_uc002axp.2_Silent_p.L390L|CCDC33_uc002axq.2_Silent_p.L161L|CCDC33_uc002axr.2_Silent_p.L161L	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	771	Potential.						protein binding			ovary(3)|skin(2)	5						GGAGCGGGTGCTGGAGGACAG	0.647			NA											4	17					0	0	0.001168	0	0
LINGO1	84894	broad.mit.edu	37	15	77906791	77906791	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:77906791G>A	uc002bct.1	-	2	1510	c.1458C>T	c.(1456-1458)TAC>TAT	p.Y486Y	LINGO1_uc002bcu.1_Silent_p.Y480Y	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	486	Extracellular (Potential).|Ig-like C2-type.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						GTACCTGGGCGTAGCGCACCT	0.667			NA											11	22					0	0	0.000978	0	0
AEN	64782	broad.mit.edu	37	15	89169735	89169735	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:89169735C>T	uc002bmt.2	+	2	446	c.295C>T	c.(295-297)CCC>TCC	p.P99S	AEN_uc010bnl.2_Missense_Mutation_p.P99S|AEN_uc010bnm.1_Missense_Mutation_p.P99S	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	99					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						AAGGCCTGCTCCCGGGAAAGC	0.657			NA											24	17					0	0	0.004656	0	0
POLG	5428	broad.mit.edu	37	15	89866008	89866008	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr15:89866008C>G	uc002bns.3	-	14	2673	c.2391G>C	c.(2389-2391)ATG>ATC	p.M797I	POLG_uc002bnr.3_Missense_Mutation_p.M797I	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	797					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AGAAAGAAATCATTTTGTTGA	0.597	Colon(73;648 1203 11348 18386 27782)		NA						DNA_polymerases_(catalytic_subunits)					103	105					0	0	0.00361	0	0
MSLNL	401827	broad.mit.edu	37	16	822938	822938	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:822938C>T	uc002cjz.1	-	11	2247	c.2247G>A	c.(2245-2247)ACG>ACA	p.T749T		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	398	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GAGCCATGACCGTGTCCTGGG	0.682			NA											8	29					0	0	0.00308	0	0
UBN1	29855	broad.mit.edu	37	16	4924548	4924548	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:4924548G>A	uc002cyb.2	+	15	2476	c.2137G>A	c.(2137-2139)GAA>AAA	p.E713K	UBN1_uc010uxw.1_Missense_Mutation_p.E713K|UBN1_uc002cyc.2_Missense_Mutation_p.E713K	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	713					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						TTTATGTACAGAAGAAAAAAG	0.493			NA											43	149					0	0	0.002852	0	0
GRIN2A	2903	broad.mit.edu	37	16	9934799	9934799	+	Silent	SNP	G	G	T	rs146157761		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:9934799G>T	uc002czo.3	-	6	2039	c.1491C>A	c.(1489-1491)ATC>ATA	p.I497I	GRIN2A_uc010uym.1_Silent_p.I497I|GRIN2A_uc010uyn.1_Silent_p.I340I|GRIN2A_uc002czr.3_Silent_p.I497I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	497	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.I497I(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTACTTCACCGATCATTCCAT	0.428			NA											16	67					5.03518e-11	8.19132e-11	0.007413	1	0
GRIN2A	2903	broad.mit.edu	37	16	9943652	9943652	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:9943652A>G	uc002czo.3	-	5	1837	c.1289T>C	c.(1288-1290)GTG>GCG	p.V430A	GRIN2A_uc010uym.1_Missense_Mutation_p.V430A|GRIN2A_uc010uyn.1_Missense_Mutation_p.V273A|GRIN2A_uc002czr.3_Missense_Mutation_p.V430A	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	430	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTGTTCCTCACACACGTCTC	0.542			NA											8	64					0	0	0.006214	0	0
GRIN2A	2903	broad.mit.edu	37	16	9984903	9984903	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:9984903G>T	uc002czo.3	-	4	1610	c.1062C>A	c.(1060-1062)GGC>GGA	p.G354G	GRIN2A_uc010uym.1_Silent_p.G354G|GRIN2A_uc010uyn.1_Silent_p.G197G|GRIN2A_uc002czr.3_Silent_p.G354G	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	354	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCACCTGGTAGCCTTCCTCAG	0.463			NA											9	61					1.33987e-11	2.20435e-11	0.008291	1	0
MYH11	4629	broad.mit.edu	37	16	15808819	15808819	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:15808819C>T	uc002ddy.2	-	40	5840	c.5733G>A	c.(5731-5733)ACG>ACA	p.T1911T	MYH11_uc002ddv.2_Silent_p.T1918T|MYH11_uc002ddw.2_Silent_p.T1911T|MYH11_uc002ddx.2_Silent_p.T1918T|MYH11_uc010bvg.2_Silent_p.T1743T|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Silent_p.T617T	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1911	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGTTGCTCTCCGTGGCCTCAT	0.657			NA	T	CBFB	AML								34	115					0	0	0.005524	0	0
GPRC5B	51704	broad.mit.edu	37	16	19873269	19873269	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:19873269C>T	uc002dgt.2	-	3	1165	c.1057G>A	c.(1057-1059)GGC>AGC	p.G353S	GPRC5B_uc010vav.1_Missense_Mutation_p.G379S	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	353	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						CCCAAGCTGCCGTTGGGAAAT	0.512			NA											5	30					0	0	0.001168	0	0
UMOD	7369	broad.mit.edu	37	16	20352594	20352594	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:20352594G>T	uc002dgz.2	-	7	1525	c.1396C>A	c.(1396-1398)CCT>ACT	p.P466T	UMOD_uc002dha.2_Missense_Mutation_p.P466T|UMOD_uc002dhb.2_Missense_Mutation_p.P499T	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	466	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						GTGTAGGAAGGGGTCTGGAAG	0.612			NA											9	32					0.000673444	0.000757755	0.008291	1	0
ACSM2A	123876	broad.mit.edu	37	16	20487038	20487038	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:20487038G>A	uc010bwe.2	+	9	1280	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E	ACSM2A_uc010vax.1_Silent_p.E268E|ACSM2A_uc002dhf.3_Silent_p.E347E|ACSM2A_uc002dhg.3_Silent_p.E347E|ACSM2A_uc010vay.1_Silent_p.E268E|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	347					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						AAACTCTGGAGAACTGGAGGG	0.517			NA											25	138					0	0	0.00632	0	0
ACSM1	116285	broad.mit.edu	37	16	20648142	20648142	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:20648142G>T	uc002dhm.1	-	9	1286	c.1218C>A	c.(1216-1218)AGC>AGA	p.S406R	ACSM1_uc002dhn.1_Intron|ACSM1_uc010bwg.1_Missense_Mutation_p.S406R	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	406					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						GTGGCAGGATGCTGCCCTTGT	0.532			NA											8	35					1.76689e-08	2.62778e-08	0.006214	1	0
OTOA	146183	broad.mit.edu	37	16	21698943	21698943	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:21698943C>G	uc002djh.2	+	7	610	c.609C>G	c.(607-609)GAC>GAG	p.D203E	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.D124E	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	203					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TCCCTCGGGACCTGCGCGAGG	0.438			NA											4	19					0	0	0.009096	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25255428	25255428	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:25255428C>A	uc002dod.3	-	6	2066	c.1659G>T	c.(1657-1659)AAG>AAT	p.K553N	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.K349N	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	553					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GGCTTTTGAACTTGGTTCGGC	0.527			NA											15	73					6.72482e-11	1.08793e-10	0.003163	1	0
GTF3C1	2975	broad.mit.edu	37	16	27512582	27512582	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:27512582C>A	uc002dov.1	-	12	2031	c.1991G>T	c.(1990-1992)CGG>CTG	p.R664L	GTF3C1_uc002dou.2_Missense_Mutation_p.R664L	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	664						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGACAGGTTCCGCACCAAGCG	0.522			NA											9	61					0.00621372	0.00666704	0.006214	1	0
SBK1	388228	broad.mit.edu	37	16	28330425	28330425	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:28330425G>T	uc002dpd.2	+	3	1125	c.336G>T	c.(334-336)AAG>AAT	p.K112N		NM_001024401	NP_001019572	Q52WX2	SBK1_HUMAN	SH3-binding kinase 1	112	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|kidney(1)	2						TCATCATCAAGGTCTTTGACG	0.532			NA											12	63					2.27111e-07	3.21042e-07	0.001368	1	0
SETD1A	9739	broad.mit.edu	37	16	30977436	30977436	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:30977436G>T	uc002ead.1	+	8	2920	c.2234G>T	c.(2233-2235)CGG>CTG	p.R745L		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	745					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GCATACTCACGGGAGGCCTAC	0.672			NA											14	47					4.36969e-10	6.88557e-10	0.001855	1	0
ZNF267	10308	broad.mit.edu	37	16	31927483	31927483	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:31927483G>T	uc002ecs.3	+	4	2122	c.1913G>T	c.(1912-1914)GGC>GTC	p.G638V		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	638	C2H2-type 12.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						GAAGAATGTGGCAAAGCCTTC	0.413			NA											8	55					1.12685e-05	1.44938e-05	0.004482	1	0
ABCC12	94160	broad.mit.edu	37	16	48117862	48117862	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:48117862T>A	uc002efc.1	-	28	4297	c.3951A>T	c.(3949-3951)ACA>ACT	p.T1317T	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1317	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AGTTGAGAACTGTGTTGAGGC	0.517			NA											12	68					0	0	0.003163	0	0
ABCC11	85320	broad.mit.edu	37	16	48256510	48256510	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:48256510T>A	uc002eff.1	-	5	1126	c.776A>T	c.(775-777)GAG>GTG	p.E259V	ABCC11_uc002efg.1_Missense_Mutation_p.E259V|ABCC11_uc002efh.1_Missense_Mutation_p.E259V|ABCC11_uc010vgl.1_Missense_Mutation_p.E259V	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	259	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCTGCTTACCTCTCCTGAGGT	0.463			NA							Cerumen_Type				4	25					0	0	0.009096	0	0
GNAO1	2775	broad.mit.edu	37	16	56374811	56374811	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:56374811G>T	uc002eit.3	+	7	1686	c.789G>T	c.(787-789)ACG>ACT	p.T263T	GNAO1_uc002eiu.3_Intron	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	263					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				TCACAGACACGTCCATCATCC	0.483			NA											54	224					8.99859e-20	1.65847e-19	0.00361	1	0
CCDC113	29070	broad.mit.edu	37	16	58293790	58293790	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:58293790T>A	uc002ene.2	+	5	658	c.579T>A	c.(577-579)AAT>AAA	p.N193K	CCDC113_uc010vid.1_Missense_Mutation_p.N139K	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	193	Potential.					protein complex					0						GTTTGAAAAATGTTTCTCTCA	0.308			NA											8	51					0	0	0.004482	0	0
CDH8	1006	broad.mit.edu	37	16	61854978	61854978	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:61854978C>A	uc002eog.1	-	6	1127	c.875G>T	c.(874-876)GGC>GTC	p.G292V	CDH8_uc002eoh.2_Missense_Mutation_p.G61V	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	292	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TATTGCAGTGCCAAGAACCAC	0.383			NA											8	30					1.06961e-07	1.54041e-07	0.00308	1	0
CTCF	10664	broad.mit.edu	37	16	67670753	67670753	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:67670753G>T	uc002etl.2	+	11	2288	c.1998G>T	c.(1996-1998)CAG>CAT	p.Q666H	CTCF_uc010cek.2_Missense_Mutation_p.Q338H|CTCF_uc002etm.1_Missense_Mutation_p.Q155H	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	666					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AACAGAACCAGCGTAAGTTGT	0.597	Colon(175;1200 1966 6945 23069 27405)		NA											21	95					7.41877e-09	1.11935e-08	0.001882	1	0
NUTF2	10204	broad.mit.edu	37	16	67899124	67899124	+	Missense_Mutation	SNP	G	G	C	rs146730920		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:67899124G>C	uc002eup.2	+	2	190	c.91G>C	c.(91-93)GCA>CCA	p.A31P	NUTF2_uc010vkf.1_Missense_Mutation_p.A31P	NM_005796	NP_005787	P61970	NTF2_HUMAN	nuclear transport factor 2	31	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		CCAACTAGGCGCAATTTACGT	0.468			NA											9	30					0	0	0.006214	0	0
TMCO7	79613	broad.mit.edu	37	16	68961558	68961558	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:68961558G>A	uc002ewi.3	+	13	2227	c.2215G>A	c.(2215-2217)GAA>AAA	p.E739K		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	739						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		GGTCATCCAAGAACTCGCTGT	0.473			NA											14	69					0	0	0.001855	0	0
VPS4A	27183	broad.mit.edu	37	16	69350147	69350147	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:69350147G>T	uc002eww.2	+	3	281	c.153G>T	c.(151-153)AAG>AAT	p.K51N		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting factor 4A	51	Interaction with CHMP1B.|MIT.				cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)				ACAGCGACAAGGCCAAGGAGA	0.602			NA											6	38					0.00198382	0.00217995	0.001984	1	0
PDPR	55066	broad.mit.edu	37	16	70154580	70154580	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:70154580C>G	uc002eyf.1	+	3	1142	c.185C>G	c.(184-186)TCC>TGC	p.S62C	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Intron	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	62					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		TATCACCTCTCCAAAATGGGG	0.557			NA											13	31					0	0	0.001855	0	0
ST3GAL2	6483	broad.mit.edu	37	16	70415690	70415690	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:70415690C>G	uc002eyw.2	-	6	3063	c.955G>C	c.(955-957)GAG>CAG	p.E319Q	ST3GAL2_uc002eyx.2_Missense_Mutation_p.E319Q	NM_006927	NP_008858	Q16842	SIA4B_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	319	Lumenal (Potential).				amino sugar metabolic process	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			ovary(1)	1		Ovarian(137;0.0694)				TTCCGGAACTCGCCCGCGTAC	0.652			NA											5	42					0	0	0.001168	0	0
HYDIN	54768	broad.mit.edu	37	16	70926292	70926292	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:70926292A>T	uc002ezr.2	-	56	9514	c.9386T>A	c.(9385-9387)ATT>AAT	p.I3129N		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3130										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTGGTGCTCAATCTTCACTTC	0.478			NA											6	73					0	0	0.001168	0	0
WDR59	79726	broad.mit.edu	37	16	74951836	74951836	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:74951836C>G	uc002fdh.1	-	11	1059	c.957G>C	c.(955-957)CAG>CAC	p.Q319H	WDR59_uc002fdi.2_Missense_Mutation_p.Q319H|WDR59_uc002fdj.2_Missense_Mutation_p.Q319H|WDR59_uc002fdg.1_5'Flank	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	319	WD 7.									ovary(1)|breast(1)	2						CCCTCTGCATCTGGGAATCCA	0.453			NA											9	54					0	0	0.006214	0	0
BCAR1	9564	broad.mit.edu	37	16	75268814	75268814	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:75268814C>A	uc002fdv.2	-	5	2106	c.1983G>T	c.(1981-1983)ATG>ATT	p.M661I	BCAR1_uc002fdt.2_Missense_Mutation_p.M114I|BCAR1_uc002fdu.2_Missense_Mutation_p.M451I|BCAR1_uc010cgu.2_Missense_Mutation_p.M650I|BCAR1_uc010vna.1_Missense_Mutation_p.M659I|BCAR1_uc010vnb.1_Missense_Mutation_p.M707I|BCAR1_uc002fdw.2_Missense_Mutation_p.M661I|BCAR1_uc010vnc.1_Missense_Mutation_p.M513I|BCAR1_uc010vnd.1_Missense_Mutation_p.M679I|BCAR1_uc002fdx.2_Missense_Mutation_p.M679I	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	661					actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		CATAGTCCTCCATCCAGCCCC	0.632			NA											5	30					5.9392e-07	8.25141e-07	0.001168	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76389295	76389295	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:76389295G>T	uc002feu.1	+	5	662	c.277G>T	c.(277-279)GCT>TCT	p.A93S	CNTNAP4_uc002fev.1_Missense_Mutation_p.A5S|CNTNAP4_uc010chb.1_Missense_Mutation_p.A68S|CNTNAP4_uc002fex.1_Missense_Mutation_p.A96S|CNTNAP4_uc002few.2_Missense_Mutation_p.A68S	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	93	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.A68T(1)		ovary(1)|pancreas(1)	2						GGAGGTCACCGCTGTGGCCAC	0.483			NA											5	39					0.000602214	0.000682885	0.000602	1	0
PLCG2	5336	broad.mit.edu	37	16	81960739	81960739	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:81960739G>A	uc002fgt.2	+	23	2622	c.2470G>A	c.(2470-2472)GTC>ATC	p.V824I		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	824	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						ATCCAACTACGTCGAGGACAT	0.522			NA											25	93					0	0	0.00632	0	0
HSD17B2	3294	broad.mit.edu	37	16	82131939	82131939	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:82131939G>T	uc002fgv.2	+	5	1234	c.1062G>T	c.(1060-1062)TTG>TTT	p.L354F		NM_002153	NP_002144	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	354					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2					NADH(DB00157)	CTCACTATTTGCCTATTGGCA	0.473			NA											14	72					0.00400662	0.00436324	0.004007	1	0
MPHOSPH6	10200	broad.mit.edu	37	16	82197792	82197792	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:82197792T>G	uc002fgw.2	-	2	108	c.59A>C	c.(58-60)CAA>CCA	p.Q20P		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	20					M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						CAGTCCCCTTTGCATAAACTG	0.363			NA											8	44					0	0	0.004482	0	0
LRRC50	123872	broad.mit.edu	37	16	84203839	84203839	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:84203839C>T	uc002fhl.3	+	8	1586	c.1405C>T	c.(1405-1407)CCA>TCA	p.P469S	LRRC50_uc010vnw.1_Missense_Mutation_p.P233S	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	469	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						GGGGACCCTCCCAGCTGAGAC	0.637			NA							Kartagener_syndrome				6	34					0	0	0.00308	0	0
KCNG4	93107	broad.mit.edu	37	16	84256462	84256462	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:84256462G>T	uc010voc.1	-	3	1042	c.921C>A	c.(919-921)TAC>TAA	p.Y307*		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	307	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CCAGCGACACGTAGTATGGGG	0.642			NA											4	15					0.00909568	0.00969496	0.009096	1	0
KLHL36	79786	broad.mit.edu	37	16	84690773	84690773	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:84690773G>T	uc002fig.2	+	3	501	c.360G>T	c.(358-360)CTG>CTT	p.L120L	KLHL36_uc010chl.2_Silent_p.L119L	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	120										skin(2)	2						ACTACGTCCTGGAGACGGCTC	0.607			NA											12	32					1.5842e-08	2.37548e-08	0.001855	1	0
COX4I1	1327	broad.mit.edu	37	16	85838628	85838628	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:85838628G>C	uc002fje.2	+	3	323	c.159G>C	c.(157-159)AAG>AAC	p.K53N	COX4I1_uc002fjf.2_Missense_Mutation_p.K53N|COX4I1_uc002fjg.1_Missense_Mutation_p.K53N|COX4I1_uc010vom.1_5'UTR	NM_001861	NP_001852	P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	53					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			lung(1)	1		Renal(780;0.228)				CCCATGTCAAGCACCTGTCTG	0.532			NA											7	23					0	0	0.001984	0	0
P2RX5	5026	broad.mit.edu	37	17	3593445	3593445	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:3593445C>A	uc002fwi.2	-	6	818	c.534_splice	c.e6-1	p.E178_splice	P2RX5_uc002fwd.2_Splice_Site|P2RX5_uc002fwh.1_Splice_Site_p.E178_splice|P2RX5_uc010vrx.1_Splice_Site_p.E118_splice|P2RX5_uc002fwj.2_Splice_Site_p.E154_splice|P2RX5_uc002fwk.2_Splice_Site_p.E178_splice|P2RX5_uc002fwl.2_Splice_Site_p.E154_splice	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A						nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GAATGGCTCCCTGAAAACCAA	0.577			NA											29	79					3.65163e-15	6.37502e-15	0.00632	1	0
PFN1	5216	broad.mit.edu	37	17	4851651	4851651	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:4851651C>A	uc002gaa.2	-	1	175	c.39G>T	c.(37-39)GCG>GCT	p.A13A	PFN1_uc002fzz.2_5'Flank|ENO3_uc010vsr.1_5'Flank|ENO3_uc002gab.3_5'Flank|ENO3_uc002gac.3_5'Flank|ENO3_uc010vss.1_5'Flank	NM_005022	NP_005013	P07737	PROF1_HUMAN	profilin 1	13					actin cytoskeleton organization|platelet activation|platelet degranulation	actin cytoskeleton|cytoplasm	actin binding|proline-rich region binding				0						AGGTCCCGTCCGCCATGAGGT	0.682			NA											7	11					2.0095e-06	2.69165e-06	0.001984	1	0
ENO3	2027	broad.mit.edu	37	17	4856631	4856631	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:4856631A>G	uc002gab.3	+	5	399	c.305A>G	c.(304-306)AAT>AGT	p.N102S	ENO3_uc010vsr.1_Missense_Mutation_p.N9S|ENO3_uc002gac.3_Missense_Mutation_p.N102S|ENO3_uc010vss.1_Intron|ENO3_uc010vst.1_5'Flank	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	102					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						GGGACCGAGAATAAGTGTGAG	0.517			NA											18	40					0	0	0.00499	0	0
FBXO39	162517	broad.mit.edu	37	17	6683885	6683885	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:6683885A>T	uc010vtg.1	+	2	818	c.698A>T	c.(697-699)TAC>TTC	p.Y233F		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	233										ovary(1)|skin(1)	2						AACCTCAACTACAACTGTATC	0.502			NA											8	50					0	0	0.00308	0	0
NLGN2	57555	broad.mit.edu	37	17	7317710	7317710	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:7317710G>T	uc002ggt.1	+	3	629	c.556G>T	c.(556-558)GGC>TGC	p.G186C		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	186	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				TCTCCATGGCGGCTCCTACAT	0.597			NA											6	23					0.000157383	0.000187214	0.00308	1	0
POLR2A	5430	broad.mit.edu	37	17	7406782	7406782	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:7406782G>A	uc002ghf.3	+	18	3241	c.3007G>A	c.(3007-3009)GAC>AAC	p.D1003N		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1003					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CCTTCCCTCCGACCTGCACCC	0.567			NA											6	22					0	0	0.00308	0	0
CNTROB	116840	broad.mit.edu	37	17	7838353	7838353	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:7838353C>T	uc002gjq.2	+	5	1403	c.484C>T	c.(484-486)CTG>TTG	p.L162L	CNTROB_uc002gjp.2_Silent_p.L162L|CNTROB_uc002gjr.2_Silent_p.L64L|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	162					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				AGCCCAAGCCCTGGAGGAGCT	0.473			NA											10	45					0	0	0.006214	0	0
CCDC42	146849	broad.mit.edu	37	17	8647024	8647024	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:8647024G>A	uc002gln.2	-	3	441	c.214C>T	c.(214-216)CTG>TTG	p.L72L	CCDC42_uc002glo.2_Silent_p.L72L	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	72	Potential.									ovary(1)	1						CGCAGGTTCAGGGTTTCCATT	0.577			NA											7	12					0	0	0.00308	0	0
GAS7	8522	broad.mit.edu	37	17	9923093	9923093	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:9923093C>A	uc002gmg.1	-	2	465	c.304_splice	c.e2+1	p.E102_splice	GAS7_uc010vvd.1_Intron|GAS7_uc002gmi.2_Splice_Site_p.E38_splice|GAS7_uc002gmj.1_Splice_Site_p.E42_splice|GAS7_uc010coh.1_Splice_Site_p.E42_splice	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c						cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						GCGGGACTCACCATTGGTGGT	0.607			NA	T	MLL	AML*								8	37					7.48243e-07	1.03265e-06	0.006214	1	0
MYH1	4619	broad.mit.edu	37	17	10404645	10404645	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:10404645C>A	uc002gmo.2	-	27	3614	c.3520G>T	c.(3520-3522)GAG>TAG	p.E1174*	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1174	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TTCTGGAACTCAGCCTCCCGC	0.607			NA											23	83					2.98393e-07	4.20989e-07	0.00278	1	0
MYH2	4620	broad.mit.edu	37	17	10435163	10435163	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:10435163C>A	uc010coi.2	-	22	2612	c.2484G>T	c.(2482-2484)ATG>ATT	p.M828I	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.M828I|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	828					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCTTGACATTCATGAAGGATC	0.418			NA											16	49					2.32078e-09	3.57952e-09	0.003163	1	0
NOS2	4843	broad.mit.edu	37	17	26092683	26092683	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:26092683G>T	uc002gzu.2	-	20	2570	c.2306C>A	c.(2305-2307)CCG>CAG	p.P769Q		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	769	FAD (By similarity).|FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTGCTCCCCCGGCAGGTAGTT	0.622			NA											8	29					0.000274275	0.000319476	0.004482	1	0
ALDOC	230	broad.mit.edu	37	17	26902193	26902193	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:26902193C>A	uc002hbp.2	-	3	417	c.272G>T	c.(271-273)GGT>GTT	p.G91V	ALDOC_uc010cro.2_Missense_Mutation_p.G91V	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	91					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					GAAGGGAACACCATTATCATC	0.522			NA									OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	25					5.4927e-09	8.34799e-09	0.004482	1	0
SGK494	124923	broad.mit.edu	37	17	26938634	26938634	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:26938634C>A	uc002hbr.1	-	9	794	c.762G>T	c.(760-762)GTG>GTT	p.V254V	SGK494_uc010waq.1_Intron|SGK494_uc010war.1_Intron|uc010crq.1_5'Flank|uc002hbs.1_5'Flank	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						CTCCCTGGGGCACGTGGCGGG	0.498			NA											29	85					3.57733e-08	5.26652e-08	0.009535	1	0
MYO1D	4642	broad.mit.edu	37	17	30986161	30986161	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:30986161C>T	uc002hho.1	-	17	2329	c.2317G>A	c.(2317-2319)GAG>AAG	p.E773K	MYO1D_uc002hhp.1_Missense_Mutation_p.E773K	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	773						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			AGGGCCTCCTCAAAACGGCGA	0.517			NA									OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	52					0	0	0.006214	0	0
TMEM132E	124842	broad.mit.edu	37	17	32954040	32954040	+	Missense_Mutation	SNP	C	C	G	rs150343983	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:32954040C>G	uc002hif.2	+	3	1020	c.692C>G	c.(691-693)TCG>TGG	p.S231W		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	231	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		AACTCCTCCTCGCCCTCCAGC	0.597			NA											7	44					0	0	0.00308	0	0
TMEM132E	124842	broad.mit.edu	37	17	32956090	32956090	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:32956090G>T	uc002hif.2	+	5	1263	c.935G>T	c.(934-936)AGC>ATC	p.S312I		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	312	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		AACTTCACCAGCCAGTCAGTC	0.607			NA											14	67					7.93312e-07	1.09071e-06	0.00245	1	0
TAF15	8148	broad.mit.edu	37	17	34171871	34171871	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:34171871G>T	uc002hkd.2	+	15	1654	c.1568G>T	c.(1567-1569)GGA>GTA	p.G523V	TAF15_uc002hkc.2_Missense_Mutation_p.G520V	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	523	Arg/Gly-rich.|15.|21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		ggaggctatggaggagACAGA	0.303			NA	T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								5	22					0.000602214	0.000682885	0.000602	1	0
MLLT6	4302	broad.mit.edu	37	17	36861986	36861986	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:36861986T>A	uc002hqi.3	+	1	114	c.101T>A	c.(100-102)GTC>GAC	p.V34D	MLLT6_uc010wdr.1_Missense_Mutation_p.V34D|MLLT6_uc010cvm.1_Missense_Mutation_p.V34D	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	34	PHD-type 1.				regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					AGCGTGGTCGTCCACCAAGGT	0.453			NA	T	MLL	AL								7	28					0	0	0.00308	0	0
CDK12	51755	broad.mit.edu	37	17	37676281	37676281	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:37676281A>G	uc010cvv.2	+	11	3622	c.3036A>G	c.(3034-3036)GAA>GAG	p.E1012E	CDK12_uc010wef.1_Silent_p.E1011E|CDK12_uc002hrw.3_Silent_p.E1012E	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1012	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.T1014_Q1016del(1)		ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GCACAGCTGAACAGACCCTAC	0.463			NA								TCGA Ovarian(9;0.13)			16	80					0	0	0.006122	0	0
KRT25	147183	broad.mit.edu	37	17	38910703	38910703	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:38910703G>A	uc002hve.2	-	2	508	c.447C>T	c.(445-447)ACC>ACT	p.T149T		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	149	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TAGCATTGCTGGTGGTGGATG	0.383			NA											7	50					0	0	0.004482	0	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316515	39316515	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:39316515G>T	uc002hwc.2	-	1	469	c.429C>A	c.(427-429)ACC>ACA	p.T143T		NM_032524	NP_115913	Q9BYR3	KRA44_HUMAN	keratin associated protein 4.4	143	26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].|24.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GGCAGCAGGTGGTTCTGCAGC	0.632			NA											11	36					0.000673444	0.000757755	0.008291	1	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394396	39394396	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:39394396C>T	uc002hwh.3	+	1	127	c.93C>T	c.(91-93)CCC>CCT	p.P31P	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	31	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCAGCACACCCTGCTGCCAGC	0.617			NA											9	60					0	0	0.008291	0	0
KRT33B	3884	broad.mit.edu	37	17	39521116	39521116	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:39521116C>A	uc002hwl.2	-	6	1057	c.1012G>T	c.(1012-1014)GAG>TAG	p.E338*		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	338	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				ACCTGATACTCCTGGTTCTGC	0.642			NA											8	63					2.80697e-09	4.31569e-09	0.000978	1	0
KRT34	3885	broad.mit.edu	37	17	39535402	39535402	+	Silent	SNP	C	C	T	rs148874673	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:39535402C>T	uc002hwm.2	-	6	1041	c.1029G>A	c.(1027-1029)ACG>ACA	p.T343T		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	343	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				CCTCGCTCTCCGTCAGCGTGT	0.572			NA											4	42					0	0	0.009096	0	0
AOC3	8639	broad.mit.edu	37	17	41004452	41004452	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:41004452C>A	uc002ibv.2	+	1	1252	c.1092C>A	c.(1090-1092)AGC>AGA	p.S364R		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	364	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	ATGAGATAAGCCTCCAAGAGG	0.537	NSCLC(3;192 220 10664 11501 16477)		NA											12	54					6.40141e-05	7.85211e-05	0.000978	1	0
NBR1	4077	broad.mit.edu	37	17	41352478	41352478	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:41352478A>T	uc010czd.2	+	17	2461	c.2321A>T	c.(2320-2322)CAG>CTG	p.Q774L	NBR1_uc010diz.2_Missense_Mutation_p.Q774L|NBR1_uc010whu.1_Missense_Mutation_p.Q774L|NBR1_uc010whv.1_Missense_Mutation_p.Q774L|NBR1_uc010whw.1_Missense_Mutation_p.Q753L	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	774					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GAGGCTGGGCAGGAACCAGCT	0.607			NA											5	13					0	0	0.001168	0	0
GFAP	2670	broad.mit.edu	37	17	42992785	42992785	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:42992785C>A	uc002ihq.2	-	1	130	c.70G>T	c.(70-72)GGC>TGC	p.G24C	GFAP_uc002ihr.2_Missense_Mutation_p.G24C|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	24	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				GGAGCCAGGCCCCCCACCATC	0.692			NA											4	10					0.00909568	0.00969496	0.009096	1	0
FMNL1	752	broad.mit.edu	37	17	43313572	43313572	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:43313572C>T	uc002iin.2	+	7	884	c.684C>T	c.(682-684)CAC>CAT	p.H228H		NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	228	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						ACGACGTCCACGTCTGTATTA	0.642	GBM(164;1247 1997 8702 11086 51972)		NA									OREG0024477	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	22					0	0	0.001984	0	0
C17orf46	124783	broad.mit.edu	37	17	43333141	43333141	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:43333141G>A	uc002iis.1	-	4	504	c.408C>T	c.(406-408)TTC>TTT	p.F136F	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Silent_p.F115F	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	136										large_intestine(1)|ovary(1)	2						TCTCCTCCGTGAAACTCCGGC	0.567			NA											16	70					0	0	0.00499	0	0
KIAA1267	284058	broad.mit.edu	37	17	44110791	44110791	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:44110791C>A	uc002ikb.2	-	11	2787	c.2702G>T	c.(2701-2703)AGT>ATT	p.S901I	KIAA1267_uc002ikc.2_Missense_Mutation_p.S901I|KIAA1267_uc002ikd.2_Missense_Mutation_p.S901I|KIAA1267_uc010dav.2_Missense_Mutation_p.S900I|KIAA1267_uc010wkb.1_Missense_Mutation_p.S232I|KIAA1267_uc010wkc.1_Missense_Mutation_p.S169I	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	901						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTCATCAGGACTCCCCTTCAG	0.483			NA											9	38					0.000673444	0.000757755	0.008291	1	0
HOXB1	3211	broad.mit.edu	37	17	46607968	46607968	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:46607968G>T	uc002ink.1	-	1	305	c.299C>A	c.(298-300)CCT>CAT	p.P100H		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	100						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTGACCCAGAGGGTAGTACTG	0.662			NA											9	68					2.74318e-10	4.36034e-10	0.006214	1	0
ABI3	51225	broad.mit.edu	37	17	47299960	47299960	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:47299960C>A	uc002iop.1	+	8	1482	c.984C>A	c.(982-984)TCC>TCA	p.S328S	ABI3_uc002ioq.1_Silent_p.S322S	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	328	SH3.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			ATGAGCTCTCCTTCTCTGAGG	0.582			NA								HNSCC(55;0.14)			8	28					5.4927e-09	8.34799e-09	0.004482	1	0
ZNF652	22834	broad.mit.edu	37	17	47376118	47376118	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:47376118C>A	uc002iov.3	-	6	1942	c.1478G>T	c.(1477-1479)CGG>CTG	p.R493L	ZNF652_uc002iow.2_Missense_Mutation_p.R493L|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			GCTGGTCACCCGAAAGCACTT	0.572			NA											9	23					1.76689e-08	2.62778e-08	0.006214	1	0
SLC35B1	10237	broad.mit.edu	37	17	47781515	47781515	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:47781515G>A	uc002iph.1	-	6	689	c.602C>T	c.(601-603)TCC>TTC	p.S201F	SLC35B1_uc002ipi.1_Missense_Mutation_p.S134F|SLC35B1_uc002ipj.1_Missense_Mutation_p.S77F|SLC35B1_uc010wly.1_Missense_Mutation_p.S201F	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	201						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						CATGTGGTTGGAGCCTGTTTG	0.537			NA											11	41					0	0	0.000978	0	0
KIF2B	84643	broad.mit.edu	37	17	51900641	51900641	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:51900641C>A	uc002iua.2	+	1	403	c.247C>A	c.(247-249)CTG>ATG	p.L83M		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	83					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GAATCCAGCTCTGGACTCTGC	0.567			NA											26	104					1.13719e-10	1.82956e-10	0.008361	1	0
KIF2B	84643	broad.mit.edu	37	17	51900752	51900752	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:51900752C>A	uc002iua.2	+	1	514	c.358C>A	c.(358-360)CCC>ACC	p.P120T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	120					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TGCGATGATCCCCCAGAAAAA	0.592			NA											12	50					7.03913e-09	1.06427e-08	0.001368	1	0
KIF2B	84643	broad.mit.edu	37	17	51902345	51902345	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:51902345G>T	uc002iua.2	+	1	2107	c.1951G>T	c.(1951-1953)GCT>TCT	p.A651S	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	651	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GAAAATTGATGCTCTGACCGA	0.453			NA											6	28					8.12818e-05	9.82943e-05	0.001984	1	0
EPX	8288	broad.mit.edu	37	17	56271329	56271329	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:56271329G>T	uc002ivq.2	+	5	556	c.470G>T	c.(469-471)AGA>ATA	p.R157I		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	157					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						TGCAGGAGGAGACCCTTGCTA	0.677			NA											7	32					2.0095e-06	2.69165e-06	0.001984	1	0
TBX4	9496	broad.mit.edu	37	17	59556082	59556082	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:59556082G>T	uc002izi.2	+	5	689	c.644G>T	c.(643-645)TGC>TTC	p.C215F	TBX4_uc010ddo.2_Missense_Mutation_p.C215F|TBX4_uc010woy.1_Missense_Mutation_p.C215F	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	215	T-box.				leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ACTGCTTTCTGCACCCACGTG	0.532			NA											17	74					4.96729e-08	7.26872e-08	0.008871	1	0
MARCH10	162333	broad.mit.edu	37	17	60814126	60814126	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:60814126G>T	uc010ddr.2	-	6	1341	c.1103C>A	c.(1102-1104)TCT>TAT	p.S368Y	MARCH10_uc002jag.3_Missense_Mutation_p.S368Y|MARCH10_uc010dds.2_Missense_Mutation_p.S406Y|MARCH10_uc002jah.2_Missense_Mutation_p.S367Y|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	368							ligase activity|zinc ion binding				0						TTGCCCAGCAGAAGGCCGCTC	0.502			NA											26	93					1.77063e-15	3.10607e-15	0.005443	1	0
ACE	1636	broad.mit.edu	37	17	61568583	61568583	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:61568583G>A	uc002jau.1	+	19	2775	c.2753G>A	c.(2752-2754)AGG>AAG	p.R918K	ACE_uc002jav.1_Missense_Mutation_p.R344K|ACE_uc010ddv.1_Missense_Mutation_p.R145K|ACE_uc010wpj.1_Missense_Mutation_p.R344K|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.R164K	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	918	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TGGACGCCCAGGAGGATGTTT	0.617			NA											4	33					0	0	0.000602	0	0
ACE	1636	broad.mit.edu	37	17	61571364	61571364	+	Missense_Mutation	SNP	G	G	T	rs141139841		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:61571364G>T	uc002jau.1	+	21	3240	c.3218G>T	c.(3217-3219)CGC>CTC	p.R1073L	ACE_uc002jav.1_Missense_Mutation_p.R499L|ACE_uc010ddv.1_Missense_Mutation_p.R300L|ACE_uc010wpj.1_Missense_Mutation_p.R499L|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.R319L	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1073	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GATCAGTGGCGCTGGAGGGTA	0.547			NA											3	20					1.23904e-05	1.57558e-05	0.000602	1	0
GH1	2688	broad.mit.edu	37	17	61995231	61995231	+	Silent	SNP	G	G	T	rs144610881		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:61995231G>T	uc002jdj.2	-	4	407	c.345C>A	c.(343-345)CCC>CCA	p.P115P	GH1_uc002jdi.2_Silent_p.P100P|GH1_uc002jdk.2_Silent_p.P75P|GH1_uc002jdl.2_Intron|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Silent_p.P115P	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	115					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GGAACTGCACGGGCTCCAGCC	0.607			NA											11	52					3.86212e-05	4.78167e-05	0.008291	1	0
SCN4A	6329	broad.mit.edu	37	17	62022892	62022892	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:62022892G>A	uc002jds.1	-	19	3625	c.3548C>T	c.(3547-3549)GCC>GTC	p.A1183V		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1183	III.|Helical; Name=S5 of repeat III; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GAACTTGCCGGCAAACAGGTT	0.542			NA											4	183					0	0	0.009096	0	0
ABCA10	10349	broad.mit.edu	37	17	67149676	67149676	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:67149676G>A	uc010dfa.1	-	34	4856	c.3977C>T	c.(3976-3978)GCT>GTT	p.A1326V	ABCA10_uc010wqs.1_Missense_Mutation_p.A318V|ABCA10_uc010wqt.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1326	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAGCTTAAGAGCTTCCACCAA	0.418			NA											18	86					0	0	0.007413	0	0
ABCA5	23461	broad.mit.edu	37	17	67309322	67309322	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:67309322G>A	uc002jif.2	-	2	1436	c.218C>T	c.(217-219)ACT>ATT	p.T73I	ABCA5_uc002jig.2_Missense_Mutation_p.T73I|ABCA5_uc002jih.2_Missense_Mutation_p.T73I|ABCA5_uc010dfe.2_Missense_Mutation_p.T73I	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	73					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					ATTAGAAAGAGTAAACTTGTC	0.318			NA											4	36					0	0	0.001168	0	0
DNAI2	64446	broad.mit.edu	37	17	72287239	72287239	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:72287239G>T	uc002jkf.2	+	6	790	c.691G>T	c.(691-693)GTA>TTA	p.V231L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	231	WD 2.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AGATTCCCACGTACTCCTGGG	0.368			NA							Kartagener_syndrome				47	141					1.23713e-20	2.29752e-20	0.00361	1	0
EVPL	2125	broad.mit.edu	37	17	74010647	74010647	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:74010647C>A	uc002jqi.2	-	18	2461	c.2233G>T	c.(2233-2235)GTG>TTG	p.V745L	EVPL_uc010wss.1_Missense_Mutation_p.V767L|EVPL_uc010wst.1_Missense_Mutation_p.V215L	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	745	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GCATCCTGCACCACCTTCTCC	0.647			NA											9	25					2.17888e-05	2.75625e-05	0.006214	1	0
DNAH17	8632	broad.mit.edu	37	17	76435278	76435278	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:76435278A>G	uc010dhp.1	-	18	2921	c.2699T>C	c.(2698-2700)ATA>ACA	p.I900T	DNAH17_uc002jvq.2_Missense_Mutation_p.I185T|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCATTGTCTATGGTAAACCC	0.458			NA											4	19					0	0	0.000602	0	0
RNF213	57674	broad.mit.edu	37	17	78325513	78325513	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:78325513A>T	uc002jyh.1	+	7	4655	c.4432A>T	c.(4432-4434)ATA>TTA	p.I1478L	RNF213_uc010dhw.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AATCAACAAAATACGAGAAAA	0.303			NA											3	23					0	0	0.009096	0	0
ACTG1	71	broad.mit.edu	37	17	79479283	79479283	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:79479283G>A	uc002kaj.1	-	1	123	c.98C>T	c.(97-99)TCC>TTC	p.S33F	ACTG1_uc002kah.1_5'Flank|ACTG1_uc002kai.1_5'Flank|ACTG1_uc002kak.1_Missense_Mutation_p.S33F|ACTG1_uc010wun.1_Missense_Mutation_p.S33F|ACTG1_uc002kal.1_Missense_Mutation_p.S33F|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	33					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CCCGACGATGGAAGGAAACAC	0.657			NA											13	57					0	0	0.003163	0	0
LAMA1	284217	broad.mit.edu	37	18	7015759	7015759	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:7015759C>A	uc002knm.2	-	22	3182	c.3088G>T	c.(3088-3090)GAT>TAT	p.D1030Y	LAMA1_uc010wzj.1_Missense_Mutation_p.D506Y	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1030	Laminin EGF-like 11.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGTGCCCATCCTCACATTCT	0.557			NA											11	51					0.000673444	0.000757755	0.008291	1	0
LAMA1	284217	broad.mit.edu	37	18	7043261	7043261	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:7043261C>T	uc002knm.2	-	8	1214	c.1120G>A	c.(1120-1122)GAA>AAA	p.E374K	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	374	Laminin EGF-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATACAGGTTTCACAGTTGATT	0.408			NA											16	138					0	0	0.00499	0	0
ROCK1	6093	broad.mit.edu	37	18	18534823	18534823	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:18534823G>C	uc002kte.2	-	31	4715	c.3774C>G	c.(3772-3774)GCC>GCG	p.A1258A		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1258	PH.|Auto-inhibitory.|Phorbol-ester/DAG-type.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					GACACTCTAGGGCAGGGGGTG	0.433			NA											7	60					0	0	0.001984	0	0
GATA6	2627	broad.mit.edu	37	18	19762931	19762931	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:19762931C>T	uc002ktt.1	+	6	1812	c.1547C>T	c.(1546-1548)CCA>CTA	p.P516L	GATA6_uc002ktu.1_Missense_Mutation_p.P516L	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	516					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			CCCATGACTCCAACTTCCACC	0.383	Colon(8;48 282 46199 46856)|Melanoma(177;170 2725 12489 26999)		NA											7	39					0	0	0.001984	0	0
LAMA3	3909	broad.mit.edu	37	18	21338419	21338419	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:21338419G>C	uc002kuq.2	+	7	1093	c.1007G>C	c.(1006-1008)GGG>GCG	p.G336A	LAMA3_uc010dlv.1_Missense_Mutation_p.G336A|LAMA3_uc002kur.2_Missense_Mutation_p.G336A	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	336	Laminin EGF-like 1.|Domain V.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCTGCACAGGGTACAATCAG	0.617			NA											4	21					0	0	0.000602	0	0
CDH2	1000	broad.mit.edu	37	18	25570121	25570121	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:25570121C>A	uc002kwg.2	-	10	1997	c.1538G>T	c.(1537-1539)GGT>GTT	p.G513V	CDH2_uc010xbn.1_Missense_Mutation_p.G482V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	513	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CAACATGGTACCGGCATGAAG	0.403			NA											8	61					1.26484e-09	1.97386e-09	0.00308	1	0
CDH2	1000	broad.mit.edu	37	18	25572768	25572768	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:25572768T>A	uc002kwg.2	-	9	1654	c.1195A>T	c.(1195-1197)ATA>TTA	p.I399L	CDH2_uc010xbn.1_Missense_Mutation_p.I368L	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	399	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TTAGCTACTATGATGTCTACC	0.493			NA											7	42					0	0	0.00308	0	0
CDH2	1000	broad.mit.edu	37	18	25573525	25573525	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:25573525G>T	uc002kwg.2	-	8	1556	c.1097C>A	c.(1096-1098)GCC>GAC	p.A366D	CDH2_uc010xbn.1_Missense_Mutation_p.A335D	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	366	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GACGGCCGTGGCTGTGTTTGA	0.433			NA											32	111					7.11191e-15	1.23273e-14	0.002836	1	0
DSG2	1829	broad.mit.edu	37	18	29122774	29122774	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:29122774G>C	uc002kwu.3	+	14	2481	c.2293G>C	c.(2293-2295)GTT>CTT	p.V765L	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	765	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			GGCAGCTGCTGTTGCACTGAA	0.502			NA											12	38					0	0	0.000978	0	0
RNF138	51444	broad.mit.edu	37	18	29706687	29706687	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:29706687G>T	uc002kxg.2	+	7	1032	c.593G>T	c.(592-594)GGA>GTA	p.G198V	RNF138_uc002kxh.2_Missense_Mutation_p.G104V	NM_016271	NP_057355	Q8WVD3	RN138_HUMAN	ring finger protein 138 isoform 1	198					Wnt receptor signaling pathway	intracellular	ligase activity|protein kinase binding|zinc ion binding				0						CTTCCTTGGGGAGATCCTAGC	0.299			NA											10	57					0.00136819	0.00152184	0.001368	1	0
FHOD3	80206	broad.mit.edu	37	18	34081905	34081905	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:34081905C>A	uc002kzt.1	+	4	445	c.348C>A	c.(346-348)TAC>TAA	p.Y116*	FHOD3_uc002kzr.1_Nonsense_Mutation_p.Y116*|FHOD3_uc002kzs.1_Nonsense_Mutation_p.Y116*	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	116	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AAAAACTATACAACTCCAGCG	0.323			NA											4	14					0.000602214	0.000682885	0.000602	1	0
KIAA1328	57536	broad.mit.edu	37	18	34753036	34753036	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:34753036C>T	uc002kzz.2	+	9	1537	c.1515C>T	c.(1513-1515)ACC>ACT	p.T505T	KIAA1328_uc002lab.2_Silent_p.T257T|KIAA1328_uc002lac.1_Silent_p.T364T|KIAA1328_uc010dnc.1_RNA	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	505										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		TACAGCACACCACCTCCCGGT	0.398			NA											7	48					0	0	0.001984	0	0
KIAA0427	9811	broad.mit.edu	37	18	46284530	46284530	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:46284530G>C	uc002ldc.2	+	8	1110	c.825G>C	c.(823-825)ATG>ATC	p.M275I	KIAA0427_uc002ldd.2_Missense_Mutation_p.M275I|KIAA0427_uc002lde.3_5'Flank	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	275	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						AAGAGACCATGACCATCGAGA	0.647			NA											7	29					0	0	0.00308	0	0
KIAA1468	57614	broad.mit.edu	37	18	59931285	59931285	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:59931285A>T	uc002lil.2	+	17	2629	c.2414A>T	c.(2413-2415)GAG>GTG	p.E805V	KIAA1468_uc002lik.1_Missense_Mutation_p.E805V|KIAA1468_uc010xel.1_Missense_Mutation_p.E805V|KIAA1468_uc002lim.2_Missense_Mutation_p.E449V	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	805							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GGAAGTCGTGAGCAATTGGCA	0.423			NA											12	27					0	0	0.001368	0	0
RTTN	25914	broad.mit.edu	37	18	67869201	67869201	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:67869201T>C	uc002lkp.2	-	4	484	c.416A>G	c.(415-417)GAA>GGA	p.E139G	RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.E139G	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	139							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TGTTAAGATTTCAGGGTTTTT	0.363			NA											7	22					0	0	0.00308	0	0
NETO1	81832	broad.mit.edu	37	18	70461637	70461637	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:70461637G>T	uc002lkw.2	-	5	756	c.472C>A	c.(472-474)CCT>ACT	p.P158T	NETO1_uc002lkx.1_Missense_Mutation_p.P157T|NETO1_uc002lky.1_Missense_Mutation_p.P158T	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	158	Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TTAAAGTCAGGATCTTAAAAA	0.299			NA											19	52					2.37509e-13	4.01176e-13	0.010504	1	0
CNDP1	84735	broad.mit.edu	37	18	72247405	72247405	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:72247405A>G	uc002llq.2	+	10	1418	c.1207A>G	c.(1207-1209)AGT>GGT	p.S403G	CNDP1_uc002lls.2_Missense_Mutation_p.S206G	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	403					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		CAAAAGAAATAGTTCCAACAA	0.388	Melanoma(32;1029 1042 25286 38395 44237)		NA											7	17					0	0	0.001984	0	0
ZNF236	7776	broad.mit.edu	37	18	74592256	74592256	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:74592256A>G	uc002lmi.2	+	8	1364	c.1166A>G	c.(1165-1167)AAC>AGC	p.N389S	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.N389S	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	389					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GTGGGCATCAACCAGGACATT	0.587			NA											5	27					0	0	0.000602	0	0
SALL3	27164	broad.mit.edu	37	18	76753771	76753771	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:76753771A>T	uc002lmt.2	+	2	1780	c.1780A>T	c.(1780-1782)ACT>TCT	p.T594S	SALL3_uc010dra.2_Missense_Mutation_p.T201S	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCCGCCCCTCACTAAAGCCGA	0.736			NA											3	4					0	0	0.004672	0	0
SALL3	27164	broad.mit.edu	37	18	76757010	76757010	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr18:76757010G>T	uc002lmt.2	+	3	3591	c.3591G>T	c.(3589-3591)CAG>CAT	p.Q1197H	SALL3_uc010dra.2_Missense_Mutation_p.Q732H	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		AAATGTTCCAGAAGGACCTGG	0.577			NA											10	38					0.000442599	0.000512261	0.006214	1	0
S1PR4	8698	broad.mit.edu	37	19	3179494	3179494	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:3179494A>G	uc002lxg.2	+	1	729	c.704A>G	c.(703-705)CAG>CGG	p.Q235R		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	235	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						GCCAGCGGGCAGAAGGCCCCA	0.677	GBM(82;318 1638 33279 49708)		NA											22	32					0	0	0.003954	0	0
ITGB1BP3	27231	broad.mit.edu	37	19	3942236	3942236	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:3942236G>T	uc002lyz.3	+	8	948	c.658G>T	c.(658-660)GCC>TCC	p.A220S	ITGB1BP3_uc010xia.1_Missense_Mutation_p.A225S	NM_170678	NP_733778	Q9NPI5	NRK2_HUMAN	integrin beta 1 binding protein 3	220					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|protein binding|ribosylnicotinamide kinase activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACAGAACGGCCAGGCCTGC	0.667			NA											4	14					0.000602214	0.000682885	0.000602	1	0
SEMA6B	10501	broad.mit.edu	37	19	4556015	4556015	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:4556015C>A	uc010duc.1	-	5	494	c.456G>T	c.(454-456)GTG>GTT	p.V152V	SEMA6B_uc010dud.2_Silent_p.V152V|SEMA6B_uc010xih.1_Silent_p.V152V	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	152	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTTGGCGCACACCGGGTTGA	0.627			NA											11	28					0.00185496	0.00205542	0.001855	1	0
TUBB4	10382	broad.mit.edu	37	19	6495419	6495419	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:6495419G>T	uc002mfg.1	-	4	1198	c.1091C>A	c.(1090-1092)GCC>GAC	p.A364D	TUBB4_uc002mff.1_Missense_Mutation_p.A292D|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	364					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GAAGGTCGCGGCCATCTTCAG	0.622			NA											48	99					5.39261e-20	9.97667e-20	0.00361	1	0
PEX11G	92960	broad.mit.edu	37	19	7543247	7543247	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:7543247C>A	uc002mgk.1	-	4	453	c.444G>T	c.(442-444)CTG>CTT	p.L148L	PEX11G_uc002mgl.1_Silent_p.L78L	NM_080662	NP_542393	Q96HA9	PX11C_HUMAN	peroxisomal biogenesis factor 11 gamma	148	Helical; (Potential).					integral to membrane|peroxisomal membrane					0						TCAGTTTCAGCAGCATCCACA	0.677			NA											6	13					0.00198382	0.00217995	0.001984	1	0
PNPLA6	10908	broad.mit.edu	37	19	7606248	7606248	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:7606248G>T	uc010xjq.1	+	10	1155	c.960G>T	c.(958-960)ATG>ATT	p.M320I	PNPLA6_uc002mgq.1_Missense_Mutation_p.M272I|PNPLA6_uc010xjp.1_Missense_Mutation_p.M272I|PNPLA6_uc002mgr.1_Missense_Mutation_p.M272I|PNPLA6_uc002mgs.2_Missense_Mutation_p.M311I	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	311	cNMP 1.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						AGATCATCATGGTGCGGCTGC	0.642			NA											4	22					0.00909568	0.00969496	0.009096	1	0
FBN3	84467	broad.mit.edu	37	19	8130964	8130964	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:8130964C>A	uc002mjf.2	-	63	8290	c.8269G>T	c.(8269-8271)GGC>TGC	p.G2757C	FBN3_uc002mje.2_Missense_Mutation_p.G553C	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2757						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GAGCTGACGCCACGGAGGTGA	0.682			NA											20	60					4.35082e-09	6.67523e-09	0.010504	1	0
ACTL9	284382	broad.mit.edu	37	19	8808127	8808127	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:8808127C>A	uc002mkl.2	-	1	1046	c.925G>T	c.(925-927)GGG>TGG	p.G309W		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	309						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						GGTGACAGCCCCGGGACCTCT	0.642			NA											15	43					1.02788e-11	1.6949e-11	0.00499	1	0
MUC16	94025	broad.mit.edu	37	19	9076553	9076553	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:9076553G>T	uc002mkp.2	-	3	11097	c.10893C>A	c.(10891-10893)CCC>CCA	p.P3631P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3632	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TACGGCCATGGGGAGTAGACA	0.438			NA											16	45					0.006122	0.00658806	0.006122	1	0
MUC16	94025	broad.mit.edu	37	19	9082905	9082906	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:9082905_9082906CA>AT	uc002mkp.2	-	1	9113_9114	c.8909_8910TG>AT	c.(8908-8910)ATG>AAT	p.M2970N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2971	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATGCCCTGCCATAGAAGGGGA	0.51			NA											34	54					0	0	0.004672	0	0
MUC16	94025	broad.mit.edu	37	19	9088391	9088391	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:9088391C>A	uc002mkp.2	-	1	3628	c.3424G>T	c.(3424-3426)GAT>TAT	p.D1142Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1142	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGCCAGGATCAGGAGATGGA	0.458			NA											15	27					2.62699e-14	4.50518e-14	0.003163	1	0
MUC16	94025	broad.mit.edu	37	19	9089293	9089293	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:9089293G>A	uc002mkp.2	-	1	2726	c.2522C>T	c.(2521-2523)CCA>CTA	p.P841L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	841	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAGACACTTGGGAGGCTGAG	0.468			NA											31	55					0	0	0.003271	0	0
FBXL12	54850	broad.mit.edu	37	19	9921870	9921870	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:9921870C>A	uc002mme.2	-	3	925	c.683G>T	c.(682-684)CGA>CTA	p.R228L	FBXL12_uc002mmd.2_Missense_Mutation_p.R175L|FBXL12_uc002mmf.2_Missense_Mutation_p.R175L|FBXL12_uc002mmg.2_Missense_Mutation_p.R175L|FBXL12_uc002mmh.2_Missense_Mutation_p.R175L	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	228	LRR 6.						protein binding			lung(1)|kidney(1)	2						GCGCACATCTCGGAGGTGGCG	0.667			NA											4	13					0.000602214	0.000682885	0.000602	1	0
ICAM5	7087	broad.mit.edu	37	19	10405227	10405227	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:10405227G>T	uc002mnu.3	+	9	2206	c.2141G>T	c.(2140-2142)CGC>CTC	p.R714L	ICAM5_uc002mnv.3_Missense_Mutation_p.R589L	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	714	Extracellular (Potential).|Ig-like C2-type 8.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GAGCAGCAGCGCGTGTCCCGA	0.697			NA											12	7					1.61879e-10	2.59577e-10	0.001368	1	0
KEAP1	9817	broad.mit.edu	37	19	10610415	10610415	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:10610415C>A	uc002moq.1	-	2	451	c.295G>T	c.(295-297)GTG>TTG	p.V99L	KEAP1_uc002mor.1_Missense_Mutation_p.V99L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	99	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GAGGCCAGCACCACCTTGTGG	0.612			NA											19	17					7.45023e-12	1.23267e-11	0.010504	1	0
TMED1	11018	broad.mit.edu	37	19	10946030	10946030	+	Splice_Site	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:10946030C>T	uc002mpy.2	-	2	300	c.184_splice	c.e2-1	p.V62_splice		NM_006858	NP_006849	Q13445	TMED1_HUMAN	interleukin 1 receptor-like 1 ligand precursor						cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CTCCGATCACCTGGGGGGCAG	0.627			NA											28	37					0	0	0.002445	0	0
LDLR	3949	broad.mit.edu	37	19	11224363	11224363	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:11224363A>G	uc002mqk.3	+	10	1679	c.1511A>G	c.(1510-1512)AAG>AGG	p.K504R	LDLR_uc010xlk.1_Missense_Mutation_p.K504R|LDLR_uc010xll.1_Missense_Mutation_p.K463R|LDLR_uc010xlm.1_Missense_Mutation_p.K357R|LDLR_uc010xln.1_Missense_Mutation_p.K377R|LDLR_uc010xlo.1_Missense_Mutation_p.K336R	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	504	Extracellular (Potential).|LDL-receptor class B 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GCGGATACCAAGGGCGTGAAG	0.587	GBM(18;201 575 7820 21545)		NA											22	17					0	0	0.00333	0	0
ASNA1	439	broad.mit.edu	37	19	12856311	12856311	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:12856311G>A	uc002muv.2	+	3	444	c.430G>A	c.(430-432)GAG>AAG	p.E144K	ASNA1_uc002muw.2_Missense_Mutation_p.E143K	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	144					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			ovary(2)	2					Adenosine triphosphate(DB00171)	CGGCATCGATGAGGCCATGAG	0.632			NA											21	25					0	0	0.010504	0	0
HOOK2	29911	broad.mit.edu	37	19	12877045	12877045	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:12877045G>C	uc002muy.2	-	15	1554	c.1383C>G	c.(1381-1383)CTC>CTG	p.L461L	HOOK2_uc010xmq.1_5'UTR|HOOK2_uc002muz.2_Silent_p.L461L	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	461	Sufficient for interaction with microtubules.|Potential.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						GAAGCCGCAGGAGCGTCTCCC	0.706			NA									OREG0025273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	6					0	0	0.001168	0	0
CYP4F2	8529	broad.mit.edu	37	19	16008282	16008282	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:16008282C>G	uc002nbs.1	-	2	190	c.140G>C	c.(139-141)CGC>CCC	p.R47P	CYP4F2_uc010xot.1_Intron|CYP4F2_uc010xou.1_5'UTR	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	47					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						ACACCGAAGGCGGCGGCAGTT	0.627			NA											9	41					0	0	0.001855	0	0
CYP4F2	8529	broad.mit.edu	37	19	16008286	16008286	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:16008286G>C	uc002nbs.1	-	2	186	c.136C>G	c.(136-138)CGC>GGC	p.R46G	CYP4F2_uc010xot.1_Intron|CYP4F2_uc010xou.1_5'UTR	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	46					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CGAAGGCGGCGGCAGTTGTCA	0.632			NA											9	41					0	0	0.001368	0	0
MYO9B	4650	broad.mit.edu	37	19	17265191	17265191	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:17265191G>A	uc010eak.2	+	6	1317	c.1165G>A	c.(1165-1167)GAG>AAG	p.E389K	MYO9B_uc002nfi.2_Missense_Mutation_p.E389K|MYO9B_uc002nfj.1_Missense_Mutation_p.E389K	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	389	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GCAGGCCATGGAGATGGTGGG	0.582			NA											13	32					0	0	0.001368	0	0
SLC5A5	6528	broad.mit.edu	37	19	17986864	17986864	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:17986864C>T	uc002nhr.3	+	5	994	c.647C>T	c.(646-648)CCC>CTC	p.P216L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	216	Extracellular (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GTGGGCGGGCCCCGCCAGGTG	0.597	Melanoma(65;1008 1708 7910 46650)		NA											21	50					0	0	0.00278	0	0
ZNF676	163223	broad.mit.edu	37	19	22363097	22363097	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:22363097C>A	uc002nqs.1	-	3	1740	c.1422G>T	c.(1420-1422)GAG>GAT	p.E474D		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TGTAAGGTTTCTCTGCAGCAT	0.393			NA											38	60					5.43694e-19	9.97e-19	0.005524	1	0
ZNF536	9745	broad.mit.edu	37	19	31039133	31039133	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:31039133C>G	uc002nsu.1	+	4	2745	c.2607C>G	c.(2605-2607)CAC>CAG	p.H869Q	ZNF536_uc010edd.1_Missense_Mutation_p.H869Q	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	869					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTGGAGATCACTCGGGGCAGG	0.582			NA											39	45					0	0	0.005524	0	0
ZNF536	9745	broad.mit.edu	37	19	31039148	31039148	+	Silent	SNP	G	G	C	rs142296958		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:31039148G>C	uc002nsu.1	+	4	2760	c.2622G>C	c.(2620-2622)ACG>ACC	p.T874T	ZNF536_uc010edd.1_Silent_p.T874T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	874					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGCAGGCCACGGGCATGTCTT	0.557			NA											41	48					0	0	0.003214	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767679	31767679	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:31767679G>T	uc002nsy.3	-	2	3085	c.3020C>A	c.(3019-3021)TCC>TAC	p.S1007Y		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	1007					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGACAGTTTGGATAAGTCCCG	0.507			NA											20	29					1.55795e-14	2.68129e-14	0.001882	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769600	31769601	+	Nonsense_Mutation	DNP	CG	CG	AT			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:31769600_31769601CG>AT	uc002nsy.3	-	2	1163_1164	c.1098_1099CG>AT	c.(1096-1101)TACGGC>TAATGC	p.366_367YG>*C		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	366_367					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TTCTGGTGGCCGTACCGATTAT	0.559			NA											65	118					0	0	0.004672	0	0
FAM187B	148109	broad.mit.edu	37	19	35719355	35719355	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:35719355C>A	uc002nyk.1	-	1	274	c.229G>T	c.(229-231)GAG>TAG	p.E77*		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	77	Extracellular (Potential).					integral to membrane				ovary(2)	2						AGGCTGCCCTCGGGCATTATT	0.507			NA											32	36					1.62565e-12	2.7175e-12	0.002445	1	0
ZNF570	148268	broad.mit.edu	37	19	37975731	37975731	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:37975731C>T	uc002ogk.1	+	5	1736	c.1207C>T	c.(1207-1209)CAA>TAA	p.Q403*	ZNF570_uc010efl.1_Nonsense_Mutation_p.Q459*|ZNF570_uc010xtr.1_Nonsense_Mutation_p.Q200*	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	403	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACACCTTGCTCAACATCAGAG	0.423			NA											28	40					0	0	0.007291	0	0
GGN	199720	broad.mit.edu	37	19	38877550	38877550	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:38877550G>A	uc002oij.1	-	3	487	c.352C>T	c.(352-354)CCA>TCA	p.P118S	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Missense_Mutation_p.P35S	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	118	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGGGGAACTGGAGTGCCCGCG	0.761			NA											7	4					0	0	0.001984	0	0
SERTAD3	29946	broad.mit.edu	37	19	40947909	40947909	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:40947909G>A	uc002onu.3	-	2	357	c.79C>T	c.(79-81)CAG>TAG	p.Q27*	SERTAD3_uc002onv.3_Nonsense_Mutation_p.Q27*	NM_013368	NP_037500	Q9UJW9	SRTD3_HUMAN	RPA-binding trans-activator	27	SERTA.				negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGTAGCTCTGAAGGCCTGCT	0.592			NA											6	9					0	0	0.00308	0	0
CYP2B6	1555	broad.mit.edu	37	19	41512853	41512853	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:41512853C>T	uc002opr.1	+	4	535	c.528C>T	c.(526-528)GCC>GCT	p.A176A	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	176					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CCATTACCGCCAACATCATCT	0.498			NA											14	21					0	0	0.00245	0	0
CYP2B6	1555	broad.mit.edu	37	19	41522588	41522588	+	Silent	SNP	G	G	T	rs141626689		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:41522588G>T	uc002opr.1	+	9	1339	c.1332G>T	c.(1330-1332)GCG>GCT	p.A444A	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.A244A	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	444					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TCGCCCGTGCGGAATTGTTCC	0.582			NA											16	15					5.3912e-06	7.08447e-06	0.006122	1	0
PSG11	5680	broad.mit.edu	37	19	43523025	43523025	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:43523025G>C	uc002ovm.1	-	3	713	c.606C>G	c.(604-606)CTC>CTG	p.L202L	PSG11_uc002ouw.2_Silent_p.L208L|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Silent_p.L208L|PSG11_uc002ovn.1_Silent_p.L208L|PSG11_uc002ovo.1_Silent_p.L80L|PSG11_uc002ovp.1_Silent_p.L80L	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	202	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CAAATAGAAAGAGGGTCCTGT	0.507			NA											129	172					0	0	0.00361	0	0
PSG9	5678	broad.mit.edu	37	19	43762581	43762581	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:43762581G>A	uc002owd.3	-	5	1115	c.1016C>T	c.(1015-1017)CCT>CTT	p.P339L	PSG9_uc002owe.3_Missense_Mutation_p.P246L|PSG9_uc010xwm.1_Missense_Mutation_p.P246L|PSG9_uc002owf.3_Missense_Mutation_p.P153L|PSG9_uc002owg.2_Missense_Mutation_p.P246L|PSG9_uc002owh.2_Missense_Mutation_p.P153L	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	339	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GGTGAATGAAGGGTAAATTCT	0.468			NA											59	44					0	0	0.00361	0	0
ZNF230	7773	broad.mit.edu	37	19	44515399	44515399	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:44515399G>T	uc002oyb.1	+	5	1459	c.1208G>T	c.(1207-1209)CGG>CTG	p.R403L		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	403	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				AGCTTTAGCCGGGCTTCAAGT	0.438	GBM(175;914 2069 22996 47111 52600)		NA											40	43					1.62957e-23	3.03797e-23	0.00874	1	0
CEACAM19	56971	broad.mit.edu	37	19	45183600	45183600	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:45183600G>T	uc002ozo.3	+	5	1180	c.700G>T	c.(700-702)GAT>TAT	p.D234Y	CEACAM19_uc002ozp.3_Missense_Mutation_p.D234Y	NM_020219	NP_064604	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion	234	Cytoplasmic (Potential).					integral to membrane					0	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				CCCTGCTCATGATGCTGGTAA	0.557			NA											20	32					5.26018e-13	8.8439e-13	0.001882	1	0
EXOC3L2	90332	broad.mit.edu	37	19	45716578	45716578	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:45716578G>T	uc002pay.1	-	10	1020	c.979C>A	c.(979-981)CTG>ATG	p.L327M		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	327										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GTGTTGCGCAGGCCACGGATG	0.657			NA											12	29					3.27435e-08	4.82536e-08	0.00245	1	0
ERCC2	2068	broad.mit.edu	37	19	45867586	45867586	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:45867586T>A	uc002pbj.2	-	9	769	c.722A>T	c.(721-723)AAC>ATC	p.N241I	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.N163I|ERCC2_uc002pbk.2_Missense_Mutation_p.N217I|ERCC2_uc002pbl.3_Missense_Mutation_p.N217I|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	241	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GATGCAGACGTTGTCTGGAGA	0.672			NA	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				21	15					0	0	0.002299	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997168	46997168	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:46997168C>T	uc002pes.2	-	1	2002	c.1555G>A	c.(1555-1557)GAG>AAG	p.E519K	uc002peu.1_5'Flank	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	519										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GCCTCGCTCTCGGTGTCCTCC	0.726			NA											19	21					0	0	0.010504	0	0
GRLF1	2909	broad.mit.edu	37	19	47503629	47503629	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:47503629A>G	uc010ekv.2	+	6	4184	c.4184A>G	c.(4183-4185)AAC>AGC	p.N1395S		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1395	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		ACCAGCGAGAACCTCTCCATC	0.562			NA											64	71					0	0	0.00361	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969343	47969343	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:47969343C>G	uc002pgx.2	-	2	596	c.318G>C	c.(316-318)GAG>GAC	p.E106D	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Missense_Mutation_p.E106D	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	106	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TGATGGTGATCTCCTTCTCTT	0.572			NA											18	37					0	0	0.008871	0	0
LMTK3	114783	broad.mit.edu	37	19	49013301	49013301	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:49013301C>T	uc002pjk.2	-	4	427	c.427G>A	c.(427-429)GCC>ACC	p.A143T		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGCTGCGGGGCAGGCATTGGC	0.622			NA											6	10					0	0	0.001984	0	0
HRC	3270	broad.mit.edu	37	19	49657763	49657763	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:49657763T>C	uc002pmv.2	-	1	919	c.732A>G	c.(730-732)GAA>GAG	p.E244E		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	244	4 X tandem repeats, acidic.|1-2.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		cgtcatcttcttcatGGCCTT	0.423	Melanoma(37;75 1097 24567 25669 30645)		NA											17	16					0	0	0.004007	0	0
GPR32	2854	broad.mit.edu	37	19	51273984	51273984	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:51273984C>G	uc010ycf.1	+	1	127	c.127C>G	c.(127-129)CGC>GGC	p.R43G		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	43	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGGGTCCCTCCGCCCACTGAC	0.592	Esophageal Squamous(113;152 1581 5732 15840 44398)		NA											19	14					0	0	0.007413	0	0
KLK7	5650	broad.mit.edu	37	19	51483572	51483572	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:51483572G>A	uc002puo.2	-	4	495	c.393C>T	c.(391-393)GTC>GTT	p.V131V	KLK7_uc002pup.2_Silent_p.V131V|KLK7_uc010yco.1_Silent_p.V5V|KLK7_uc010eok.2_Silent_p.V59V	NM_139277	NP_644806	P49862	KLK7_HUMAN	stratum corneum chymotryptic enzyme	131	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		AGGGCAGCCTGACTTTCTTCA	0.552			NA											15	18					0	0	0.004007	0	0
KLK9	284366	broad.mit.edu	37	19	51507026	51507026	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:51507026G>T	uc002pux.1	-	4	624	c.537C>A	c.(535-537)TAC>TAA	p.Y179*	KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_Nonsense_Mutation_p.Y150*|KLK8_uc002puq.1_5'Flank|KLK8_uc002pur.1_5'Flank|KLK8_uc002pus.1_5'Flank|KLK8_uc002put.1_5'Flank|KLK8_uc002puu.1_5'Flank|KLK9_uc002puv.1_RNA	NM_012315	NP_036447	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9 precursor	179	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		TGTGTCCAGGGTATGCCCAGT	0.572			NA											26	39					9.86323e-18	1.77954e-17	0.003954	1	0
ZNF600	162966	broad.mit.edu	37	19	53268921	53268921	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:53268921A>G	uc002qab.3	-	3	2374	c.2088T>C	c.(2086-2088)TGT>TGC	p.C696C		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	696	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CACACTCATTACACTTGTAAG	0.403	Esophageal Squamous(196;1235 2112 2375 33339 34207)		NA											43	48					0	0	0.00361	0	0
PRKCG	5582	broad.mit.edu	37	19	54403579	54403579	+	Splice_Site	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:54403579G>A	uc002qcq.1	+	12	1655	c.1373_splice	c.e12+1	p.A458_splice	PRKCG_uc010yeg.1_Splice_Site_p.A458_splice|PRKCG_uc010yeh.1_Splice_Site_p.A345_splice	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma						activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCCATGCAGCGTGAGTCTCGG	0.597			NA											15	28					0	0	0.00245	0	0
NLRP7	199713	broad.mit.edu	37	19	55450962	55450962	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:55450962G>T	uc002qih.3	-	4	1301	c.1225C>A	c.(1225-1227)CGG>AGG	p.R409R	NLRP7_uc002qig.3_Silent_p.R409R|NLRP7_uc002qii.3_Silent_p.R409R|NLRP7_uc010esk.2_Silent_p.R409R|NLRP7_uc010esl.2_Silent_p.R437R	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	409	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGCGCGCCCCGCAGCTGTGCG	0.711			NA											14	13					8.34094e-07	1.14354e-06	0.008871	1	0
NLRP9	338321	broad.mit.edu	37	19	56244283	56244283	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:56244283G>T	uc002qly.2	-	2	942	c.914C>A	c.(913-915)TCG>TAG	p.S305*		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	305	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGAGAAATACGACTTCTTTTC	0.383			NA											25	43					8.24728e-16	1.46083e-15	0.004656	1	0
NLRP8	126205	broad.mit.edu	37	19	56466489	56466489	+	Silent	SNP	G	G	T	rs149180489		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:56466489G>T	uc002qmh.2	+	3	1136	c.1065G>T	c.(1063-1065)CCG>CCT	p.P355P	NLRP8_uc010etg.2_Silent_p.P355P	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	355	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TAACCCTTCCGGGGTTTAATA	0.453			NA											31	51					2.2171e-23	4.12801e-23	0.009535	1	0
PEG3	5178	broad.mit.edu	37	19	57335796	57335796	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:57335796C>A	uc002qnu.2	-	1	579	c.228G>T	c.(226-228)CAG>CAT	p.Q76H	ZIM2_uc010ygq.1_Splice_Site|ZIM2_uc010ygr.1_Splice_Site|ZIM2_uc002qnr.2_Splice_Site|ZIM2_uc002qnq.2_Splice_Site|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_Splice_Site|PEG3_uc002qnt.2_Missense_Mutation_p.Q76H|PEG3_uc002qnv.2_Missense_Mutation_p.Q76H|PEG3_uc002qnw.2_Splice_Site|PEG3_uc002qnx.2_Splice_Site|PEG3_uc010etr.2_Missense_Mutation_p.Q76H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	76	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGGTCTCCGGCTGCAACCAAT	0.507			NA											42	52					2.00842e-17	3.61466e-17	0.002522	1	0
USP29	57663	broad.mit.edu	37	19	57640629	57640629	+	Nonsense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:57640629A>T	uc002qny.2	+	4	942	c.586A>T	c.(586-588)AAG>TAG	p.K196*		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	196					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAAGAAATATAAGACAGATTC	0.363			NA											44	30					0	0	0.00361	0	0
ZNF773	374928	broad.mit.edu	37	19	58018006	58018006	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:58018006G>A	uc002qox.2	+	4	683	c.543G>A	c.(541-543)AGG>AGA	p.R181R	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Silent_p.R180R|ZNF773_uc002qoz.2_Intron	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		CCAAAAGTAGGGAGGCCTTTC	0.478			NA											14	17					0	0	0.00245	0	0
ZNF416	55659	broad.mit.edu	37	19	58087211	58087211	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:58087211C>G	uc002qpf.2	-	3	334	c.163G>C	c.(163-165)GAT>CAT	p.D55H	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		AGCATCACATCGCGGTACAGG	0.547			NA											29	49					0	0	0.00632	0	0
MYT1L	23040	broad.mit.edu	37	2	1926489	1926489	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:1926489G>T	uc002qxe.2	-	10	1879	c.1052C>A	c.(1051-1053)CCG>CAG	p.P351Q	MYT1L_uc002qxd.2_Missense_Mutation_p.P351Q|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	351					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GTTCTGCTGCGGATTCCTCTC	0.572			NA											6	27					3.59834e-05	4.49329e-05	0.001168	1	0
RSAD2	91543	broad.mit.edu	37	2	7030450	7030450	+	Missense_Mutation	SNP	C	C	A	rs139075974	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:7030450C>A	uc002qyp.1	+	4	1018	c.882C>A	c.(880-882)AAC>AAA	p.N294K		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	294					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		CTGAATCTAACCAGAAGGTTG	0.398			NA											6	30					0.00307968	0.0033563	0.00308	1	0
KIDINS220	57498	broad.mit.edu	37	2	8891728	8891728	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:8891728C>T	uc002qzc.2	-	23	3240	c.3058G>A	c.(3058-3060)GAA>AAA	p.E1020K	KIDINS220_uc010yiv.1_Missense_Mutation_p.E786K|KIDINS220_uc002qzd.2_Missense_Mutation_p.E978K|KIDINS220_uc010yiw.1_Missense_Mutation_p.E1021K|KIDINS220_uc002qzb.2_5'Flank|KIDINS220_uc002qze.2_Missense_Mutation_p.E25K	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1020	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCATCAATTTCAAGAAGTGGC	0.323			NA											13	46					0	0	0.001368	0	0
VSNL1	7447	broad.mit.edu	37	2	17836575	17836575	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:17836575G>A	uc002rcm.2	+	4	874	c.490G>A	c.(490-492)GAC>AAC	p.D164N		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	164	3 (Potential).|EF-hand 4.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GAACAAAGATGACCAGATTAC	0.438			NA											14	43					0	0	0.00245	0	0
SMC6	79677	broad.mit.edu	37	2	17897437	17897437	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:17897437C>A	uc002rco.2	-	15	1737	c.1441G>T	c.(1441-1443)GGC>TGC	p.G481C	SMC6_uc010exo.2_Missense_Mutation_p.G481C|SMC6_uc002rcn.2_Missense_Mutation_p.G481C|SMC6_uc002rcp.1_Missense_Mutation_p.G507C|SMC6_uc002rcq.2_Missense_Mutation_p.G507C	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	481	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ACATTAGGGCCAAATCTTTTG	0.368			NA											21	82					2.39556e-15	4.19224e-15	0.00278	1	0
PUM2	23369	broad.mit.edu	37	2	20463123	20463123	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:20463123T>G	uc002rds.1	-	13	2079	c.2056A>C	c.(2056-2058)AGC>CGC	p.S686R	PUM2_uc002rdq.1_Missense_Mutation_p.S63R|PUM2_uc002rdt.1_Missense_Mutation_p.S686R|PUM2_uc002rdr.2_Missense_Mutation_p.S546R|PUM2_uc010yjy.1_Missense_Mutation_p.S607R|PUM2_uc002rdu.1_Missense_Mutation_p.S686R|PUM2_uc010yjz.1_Missense_Mutation_p.S625R	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	686	Ser-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTGGCTGCTGGAGCTAAAT	0.463			NA											12	43					0	0	0.001368	0	0
APOB	338	broad.mit.edu	37	2	21230966	21230966	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:21230966C>A	uc002red.2	-	26	8902	c.8774G>T	c.(8773-8775)GGA>GTA	p.G2925V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2925					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGACCCTTTTCCAGAAGAAGT	0.473			NA											20	101					1.37657e-19	2.53385e-19	0.001882	1	0
APOB	338	broad.mit.edu	37	2	21234459	21234459	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:21234459C>T	uc002red.2	-	26	5409	c.5281G>A	c.(5281-5283)GGC>AGC	p.G1761S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1761					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGTGATAAGCCTGCAATGTTC	0.388			NA											25	99					0	0	0.005443	0	0
ASXL2	55252	broad.mit.edu	37	2	25991666	25991666	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:25991666C>A	uc002rgs.2	-	6	797	c.576G>T	c.(574-576)CAG>CAT	p.Q192H	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	192	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGAGAGATGCTGGTTGGAGG	0.368			NA											18	93					5.35267e-07	7.46502e-07	0.007413	1	0
KIF3C	3797	broad.mit.edu	37	2	26152180	26152180	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:26152180C>A	uc002rgu.2	-	7	2939	c.2282G>T	c.(2281-2283)AGA>ATA	p.R761I	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.R759I	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	761	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACCAGGATCTGGACTTTCG	0.567			NA											9	38					0.000442599	0.000512261	0.006214	1	0
OTOF	9381	broad.mit.edu	37	2	26699016	26699016	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:26699016G>T	uc002rhk.2	-	23	2973	c.2846C>A	c.(2845-2847)CCC>CAC	p.P949H	OTOF_uc010yla.1_5'Flank|OTOF_uc002rhh.2_Missense_Mutation_p.P202H|OTOF_uc002rhi.2_Missense_Mutation_p.P259H|OTOF_uc002rhj.2_Missense_Mutation_p.P202H	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	949	Cytoplasmic (Potential).|C2 3.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGCTGACGGGTGGGAAGGC	0.672	GBM(102;732 1451 20652 24062 31372)		NA											8	21					5.18039e-06	6.82593e-06	0.00308	1	0
OTOF	9381	broad.mit.edu	37	2	26706330	26706330	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:26706330C>T	uc002rhk.2	-	13	1519	c.1392G>A	c.(1390-1392)AAG>AAA	p.K464K		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	464	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCCCAGTACCTTCTGGCCAG	0.557	GBM(102;732 1451 20652 24062 31372)		NA											6	29					0	0	0.001984	0	0
PLB1	151056	broad.mit.edu	37	2	28816594	28816594	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:28816594C>A	uc002rmb.1	+	33	2294	c.2294C>A	c.(2293-2295)ACC>AAC	p.T765N	PLB1_uc010ezj.1_Missense_Mutation_p.T754N|PLB1_uc002rmc.2_Missense_Mutation_p.T453N	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	765	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|3.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CCCGATGTCACCACACAGTAT	0.483			NA											6	27					8.12818e-05	9.82943e-05	0.001984	1	0
ALK	238	broad.mit.edu	37	2	29416528	29416528	+	Missense_Mutation	SNP	G	G	T	rs139039449		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:29416528G>T	uc002rmy.2	-	29	5332	c.4425C>A	c.(4423-4425)CAC>CAA	p.H1475Q	ALK_uc010ymo.1_Missense_Mutation_p.H407Q	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1475	Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCATATTCACGTGTCCCCCTT	0.577			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				20	65					2.98393e-07	4.20989e-07	0.00278	1	0
ALK	238	broad.mit.edu	37	2	29450489	29450489	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:29450489C>A	uc002rmy.2	-	17	3772	c.2865G>T	c.(2863-2865)GGG>GGT	p.G955G		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	955	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGAAGGAAACCCCATCTTCCC	0.522			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				15	71					6.31663e-08	9.21544e-08	0.003163	1	0
ALK	238	broad.mit.edu	37	2	29917834	29917834	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:29917834A>T	uc002rmy.2	-	3	1741	c.834T>A	c.(832-834)CCT>CCA	p.P278P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	278	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CATGCAGTGGAGGGGAATACT	0.562			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				19	68					0	0	0.007413	0	0
XDH	7498	broad.mit.edu	37	2	31599964	31599964	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:31599964T>G	uc002rnv.1	-	14	1461	c.1382A>C	c.(1381-1383)AAC>ACC	p.N461T		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	461					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GATGGTTCTGTTGGCCATTCC	0.448	Colon(66;682 1445 30109 40147)		NA											11	62					0	0	0.001368	0	0
TTC27	55622	broad.mit.edu	37	2	32958990	32958990	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:32958990G>T	uc002rom.2	+	11	1560	c.1329G>T	c.(1327-1329)CAG>CAT	p.Q443H	TTC27_uc010ymx.1_Missense_Mutation_p.Q393H|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	443	TPR 1.						protein binding			central_nervous_system(1)	1						GGGCCATTCAGGTATTTCTGT	0.333			NA											11	59					1.08611e-07	1.558e-07	0.000978	1	0
LTBP1	4052	broad.mit.edu	37	2	33500076	33500076	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:33500076C>A	uc002ros.2	+	17	2791	c.2791C>A	c.(2791-2793)CGC>AGC	p.R931S	LTBP1_uc002rot.2_Missense_Mutation_p.R605S|LTBP1_uc002rou.2_Missense_Mutation_p.R604S|LTBP1_uc002rov.2_Missense_Mutation_p.R551S|LTBP1_uc010ymz.1_Missense_Mutation_p.R604S|LTBP1_uc010yna.1_Missense_Mutation_p.R551S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	930	EGF-like 5; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTCCCAGGGCCGCTGTGAAAA	0.433			NA											14	61					1.49906e-05	1.90125e-05	0.00245	1	0
HEATR5B	54497	broad.mit.edu	37	2	37280682	37280682	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:37280682T>A	uc002rpp.1	-	17	2564	c.2468A>T	c.(2467-2469)CAG>CTG	p.Q823L		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	823							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TATGTTAAGCTGCACAGCCTG	0.308			NA											10	33					0	0	0.000978	0	0
HEATR5B	54497	broad.mit.edu	37	2	37280747	37280747	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:37280747T>G	uc002rpp.1	-	17	2499	c.2403A>C	c.(2401-2403)TTA>TTC	p.L801F		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	801							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CCAACATTTGTAATCTATAAC	0.333			NA											5	18					0	0	0.000602	0	0
SLC8A1	6546	broad.mit.edu	37	2	40397428	40397428	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:40397428G>T	uc002rrx.2	-	6	2055	c.2031C>A	c.(2029-2031)ACC>ACA	p.T677T	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Silent_p.T672T|SLC8A1_uc002rrz.2_Silent_p.T664T|SLC8A1_uc002rsa.2_Intron|SLC8A1_uc002rsd.3_Intron|SLC8A1_uc002rsb.1_Silent_p.T669T	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	677	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TACCTGCAATGGTGATTACAG	0.433			NA											6	30					5.18039e-06	6.82593e-06	0.00308	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656313	40656313	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:40656313G>T	uc002rrx.2	-	1	1132	c.1108C>A	c.(1108-1110)CGC>AGC	p.R370S	SLC8A1_uc002rry.2_Missense_Mutation_p.R370S|SLC8A1_uc002rrz.2_Missense_Mutation_p.R370S|SLC8A1_uc002rsa.2_Missense_Mutation_p.R370S|SLC8A1_uc002rsd.3_Missense_Mutation_p.R370S|SLC8A1_uc002rsb.1_Missense_Mutation_p.R370S|SLC8A1_uc010fan.1_Missense_Mutation_p.R370S|SLC8A1_uc002rsc.1_Missense_Mutation_p.R370S	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	370	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTCATGAGGCGAGTAGCTTGA	0.428			NA											21	73					0.000132079	0.0001588	0.008871	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656998	40656998	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:40656998G>C	uc002rrx.2	-	1	447	c.423C>G	c.(421-423)GCC>GCG	p.A141A	SLC8A1_uc002rry.2_Silent_p.A141A|SLC8A1_uc002rrz.2_Silent_p.A141A|SLC8A1_uc002rsa.2_Silent_p.A141A|SLC8A1_uc002rsd.3_Silent_p.A141A|SLC8A1_uc002rsb.1_Silent_p.A141A|SLC8A1_uc010fan.1_Silent_p.A141A|SLC8A1_uc002rsc.1_Silent_p.A141A	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	141	Helical; (Potential).|Alpha-1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAGATCCCAGGGCCATCAAGG	0.463			NA											10	74					0	0	0.000978	0	0
PRKCE	5581	broad.mit.edu	37	2	46378245	46378245	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:46378245G>A	uc002rut.2	+	13	1994	c.1797G>A	c.(1795-1797)GAG>GAA	p.E599E		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	599	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			TGATGTACGAGATGATGGCTG	0.572			NA											3	13					0	0	0.004672	0	0
FSHR	2492	broad.mit.edu	37	2	49190937	49190937	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:49190937C>T	uc002rww.2	-	10	1097	c.1023G>A	c.(1021-1023)GTG>GTA	p.V341V	FSHR_uc002rwx.2_Silent_p.V279V|FSHR_uc010fbn.2_Silent_p.V315V	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	341	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCACGTCAACCACTTCATTGC	0.473			NA							Gonadal_Dysgenesis_46_XX				12	77					0	0	0.000978	0	0
NRXN1	9378	broad.mit.edu	37	2	50765423	50765423	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:50765423C>A	uc010fbq.2	-	10	3708	c.2231G>T	c.(2230-2232)GGA>GTA	p.G744V	NRXN1_uc002rxb.3_Missense_Mutation_p.G376V|NRXN1_uc002rxe.3_Missense_Mutation_p.G704V|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATAGCCTGTTCCGGAACAATC	0.468			NA											22	119					1.22574e-08	1.84558e-08	0.002299	1	0
BCL11A	53335	broad.mit.edu	37	2	60689034	60689035	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:60689034_60689035GG>AA	uc002sae.1	-	4	1240_1241	c.1012_1013CC>TT	c.(1012-1014)CCT>TTT	p.P338F	BCL11A_uc002sab.2_Missense_Mutation_p.P338F|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.P304F|BCL11A_uc002sad.1_Missense_Mutation_p.P186F|BCL11A_uc002saf.1_Missense_Mutation_p.P304F	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	338	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CCTTTGCATAGGGCTGGGCCGG	0.634			NA	T	IGH@	B-CLL								11	85					0	0	0.004672	0	0
PLEK	5341	broad.mit.edu	37	2	68607577	68607577	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:68607577A>T	uc002sen.3	+	2	322	c.160A>T	c.(160-162)ACT>TCT	p.T54S	PLEK_uc010fde.2_Missense_Mutation_p.T54S	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	54	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GAAAGGGAGCACTCTGACTAG	0.463			NA											4	40					0	0	0.009096	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046344	69046344	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:69046344C>A	uc002seu.2	+	9	1454	c.1090C>A	c.(1090-1092)CCT>ACT	p.P364T	ARHGAP25_uc010fdg.2_Missense_Mutation_p.P365T|ARHGAP25_uc010yql.1_Missense_Mutation_p.P325T|ARHGAP25_uc002sev.2_Missense_Mutation_p.P358T|ARHGAP25_uc002sew.2_Missense_Mutation_p.P357T|ARHGAP25_uc002sex.2_Missense_Mutation_p.P358T|ARHGAP25_uc002sey.2_Missense_Mutation_p.P91T	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	364					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CCTGTCACCCCCTGCCCAGAA	0.517			NA											31	103					1.61788e-16	2.88327e-16	0.002445	1	0
LOXL3	84695	broad.mit.edu	37	2	74764011	74764011	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:74764011A>T	uc002smp.1	-	5	809	c.737T>A	c.(736-738)GTG>GAG	p.V246E	LOXL3_uc002smo.1_Intron|LOXL3_uc010ffm.1_Missense_Mutation_p.V246E|LOXL3_uc002smq.1_Intron|LOXL3_uc010ffn.1_Intron	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	246	SRCR 2.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CACGCACGCCACCCCATGCAG	0.637			NA											6	39					0	0	0.001984	0	0
DOK1	1796	broad.mit.edu	37	2	74783136	74783136	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:74783136C>T	uc002sms.2	+	4	592	c.570C>T	c.(568-570)GCC>GCT	p.A190A	LOXL3_uc010ffm.1_5'Flank|LOXL3_uc002smp.1_5'Flank|LOXL3_uc002smq.1_5'Flank|LOXL3_uc010ffn.1_5'Flank|DOK1_uc002smr.2_Silent_p.A51A|DOK1_uc010ffo.2_Silent_p.A51A|DOK1_uc002smt.2_Intron|DOK1_uc002smu.2_Intron|DOK1_uc010yrz.1_Silent_p.A179A|DOK1_uc002smv.2_Silent_p.A51A|DOK1_uc002smw.1_5'UTR	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	190	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						CCGTGGGGGCCCAGAGTCAGA	0.652	Esophageal Squamous(36;520 860 12502 33616 51270)		NA											5	48					0	0	0.001168	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746810	77746810	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:77746810C>A	uc002snr.2	-	3	600	c.185G>T	c.(184-186)GGG>GTG	p.G62V	LRRTM4_uc002snq.2_Missense_Mutation_p.G62V|LRRTM4_uc002sns.2_Missense_Mutation_p.G62V|LRRTM4_uc002snt.2_Missense_Mutation_p.G63V	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	62	LRR 1.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GCCTTGTGACCCTCCAGAAAT	0.438			NA											7	52					8.12818e-05	9.82943e-05	0.001984	1	0
REG1A	5967	broad.mit.edu	37	2	79348047	79348047	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:79348047C>A	uc002snz.2	+	2	163	c.60C>A	c.(58-60)AGC>AGA	p.S20R	REG1A_uc010ffx.1_Missense_Mutation_p.S20R|REG1A_uc010ysd.1_Missense_Mutation_p.S20R	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	20					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TGTCTCAGAGCCAAGGTAAGA	0.438			NA											5	32					1.23904e-05	1.57558e-05	0.000602	1	0
REG3A	5068	broad.mit.edu	37	2	79385498	79385498	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:79385498C>G	uc002sod.1	-	3	542	c.287G>C	c.(286-288)GGT>GCT	p.G96A	REG3A_uc002soe.1_Missense_Mutation_p.G96A|REG3A_uc002sof.1_Missense_Mutation_p.G96A	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	96	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GTAGCTGTTACCAATGCTCTT	0.567			NA											10	41					0	0	0.001368	0	0
KCMF1	56888	broad.mit.edu	37	2	85276557	85276557	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:85276557G>A	uc002sox.3	+	6	1014	c.670G>A	c.(670-672)GCT>ACT	p.A224T		NM_020122	NP_064507	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	224						intracellular	ligase activity|zinc ion binding			ovary(2)	2						TGGCCCTTCCGCTTCTCAGTT	0.527			NA											7	56					0	0	0.00308	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88913343	88913343	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:88913343C>A	uc002stc.3	-	2	539	c.337G>T	c.(337-339)GGG>TGG	p.G113W		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	113	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GCAATTCTCCCATCTAAAGTG	0.373	GBM(138;671 1851 16235 39058 45249)		NA											9	56					1.12685e-05	1.44938e-05	0.004482	1	0
RPIA	22934	broad.mit.edu	37	2	89037542	89037542	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:89037542G>C	uc002ste.2	+	8	828	c.787G>C	c.(787-789)GAC>CAC	p.D263H		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	263					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				CTGGAAGTTTGACCGGGTACA	0.438			NA											16	50					0	0	0.010504	0	0
ASTL	431705	broad.mit.edu	37	2	96795703	96795703	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:96795703C>A	uc010yui.1	-	8	734	c.734G>T	c.(733-735)CGG>CTG	p.R245L		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	245					proteolysis		metalloendopeptidase activity|zinc ion binding				0						CAGCCCACGCCGGCTGAAGGC	0.652			NA											13	38					4.3838e-07	6.12554e-07	0.001855	1	0
CNGA3	1261	broad.mit.edu	37	2	99013598	99013598	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:99013598G>A	uc002syt.2	+	8	2382	c.1965G>A	c.(1963-1965)CAG>CAA	p.Q655Q	CNGA3_uc002syu.2_Silent_p.Q637Q|CNGA3_uc010fij.2_Silent_p.Q659Q	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	655					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACGCCACCCAGATGAAGATGA	0.592			NA											6	21					0	0	0.001984	0	0
IL1R2	7850	broad.mit.edu	37	2	102626230	102626230	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:102626230G>T	uc002tbm.2	+	3	503	c.274G>T	c.(274-276)GCT>TCT	p.A92S	IL1R2_uc002tbn.2_Missense_Mutation_p.A92S|IL1R2_uc002tbo.1_Missense_Mutation_p.A92S	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	92	Extracellular (Potential).|Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	CCAGGACGGTGCTCTGTGGCT	0.607	Pancreas(106;189 1628 2302 5133 12295)		NA											28	149					1.68575e-08	2.51739e-08	0.007291	1	0
IL1RL2	8808	broad.mit.edu	37	2	102849440	102849440	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:102849440G>T	uc002tbs.2	+	10	1279	c.1153G>T	c.(1153-1155)GCC>TCC	p.A385S	IL1RL2_uc002tbt.2_Missense_Mutation_p.A267S	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	385	TIR.|Cytoplasmic (Potential).				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						GCTGTATGACGCCTATGTCTT	0.498			NA											8	69					0.000157383	0.000187214	0.00308	1	0
NCK2	8440	broad.mit.edu	37	2	106498470	106498470	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:106498470G>T	uc002tdg.2	+	4	1355	c.913G>T	c.(913-915)GAG>TAG	p.E305*	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Nonsense_Mutation_p.E305*	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	305	SH2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGGGGCGTGGAGGGCGACTT	0.687			NA											5	19					8.12818e-05	9.82943e-05	0.001984	1	0
SLC5A7	60482	broad.mit.edu	37	2	108626831	108626831	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:108626831C>A	uc002tdv.2	+	9	1533	c.1257C>A	c.(1255-1257)CCC>CCA	p.P419P	SLC5A7_uc010ywm.1_Silent_p.P172P|SLC5A7_uc010fjj.2_Silent_p.P419P|SLC5A7_uc010ywn.1_Silent_p.P306P	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	419	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTATCTTCCCCCAGCTGCTTT	0.498			NA											22	56					1.64293e-13	2.78476e-13	0.00333	1	0
SULT1C3	442038	broad.mit.edu	37	2	108881755	108881755	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:108881755A>T	uc010ywo.1	+	7	863	c.863A>T	c.(862-864)GAC>GTC	p.D288V		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	288						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						TTTGACAAGGACTACCAGAAG	0.458			NA											4	41					0	0	0.000602	0	0
IL1F9	56300	broad.mit.edu	37	2	113737683	113737683	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:113737683G>C	uc002tio.1	+	4	327	c.258G>C	c.(256-258)TTG>TTC	p.L86F	IL1F9_uc010fkr.1_Missense_Mutation_p.L51F	NM_019618	NP_062564	Q9NZH8	IL36G_HUMAN	interleukin 1 family, member 9	86					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						AAATGTGTTTGTATTGTGAGA	0.403	Esophageal Squamous(44;715 981 6239 42838 46707)		NA											16	41					0	0	0.00499	0	0
MARCO	8685	broad.mit.edu	37	2	119731947	119731947	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:119731947G>T	uc002tln.1	+	5	631	c.499G>T	c.(499-501)GCC>TCC	p.A167S	MARCO_uc010yyf.1_Missense_Mutation_p.A89S	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	167	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						CATGCCTGGTGCCCCTGGCCC	0.577	GBM(8;18 374 7467 11269 32796)		NA											3	8					0.004672	0.00503511	0.004672	1	0
MARCO	8685	broad.mit.edu	37	2	119752009	119752009	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:119752009G>T	uc002tln.1	+	17	1608	c.1476G>T	c.(1474-1476)GAG>GAT	p.E492D	MARCO_uc010yyf.1_Missense_Mutation_p.E414D	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	492	SRCR.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGGGCACGGAGAGTACCCTGT	0.557	GBM(8;18 374 7467 11269 32796)		NA											5	30					2.0095e-06	2.69165e-06	0.001984	1	0
IMP4	92856	broad.mit.edu	37	2	131102277	131102277	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:131102277G>T	uc002tra.1	+	3	205	c.188G>T	c.(187-189)GGA>GTA	p.G63V	CCDC115_uc002tqw.1_5'Flank|CCDC115_uc010zaf.1_5'Flank|CCDC115_uc002tqx.2_5'Flank|CCDC115_uc002tqy.1_5'Flank|CCDC115_uc002tqz.1_5'Flank	NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	63					rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					GATGATGCTGGAGGTGAAGGT	0.567			NA											10	20					3.86212e-05	4.78167e-05	0.008291	1	0
POTEE	445582	broad.mit.edu	37	2	132021506	132021506	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:132021506C>A	uc002tsn.2	+	15	2530	c.2478C>A	c.(2476-2478)ACC>ACA	p.T826T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.T426T|POTEE_uc002tsl.2_Silent_p.T408T|POTEE_uc010fmy.1_Silent_p.T290T	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	826	Actin-like.						ATP binding				0						TGTTTGAGACCTTCAACACCC	0.622			NA											14	128					6.49762e-13	1.08992e-12	0.006122	1	0
NCKAP5	344148	broad.mit.edu	37	2	133541199	133541199	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:133541199C>A	uc002ttp.2	-	14	3559	c.3185G>T	c.(3184-3186)GGA>GTA	p.G1062V	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1062							protein binding				0						AGTCTGTAATCCTATGTCCCT	0.512			NA											13	65					4.36969e-10	6.88557e-10	0.001855	1	0
CCNT2	905	broad.mit.edu	37	2	135711659	135711659	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:135711659G>A	uc002tuc.1	+	9	1666	c.1634G>A	c.(1633-1635)AGC>AAC	p.S545N	CCNT2_uc002tub.1_Missense_Mutation_p.S545N|CCNT2_uc010zbf.1_Missense_Mutation_p.S370N|CCNT2_uc002tud.1_Missense_Mutation_p.S208N	NM_058241	NP_490595	O60583	CCNT2_HUMAN	cyclin T2 isoform b	545					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			ovary(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.107)		AGTGGGAAGAGCAAACATTCA	0.463			NA											7	45					0	0	0.001984	0	0
MCM6	4175	broad.mit.edu	37	2	136598469	136598469	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:136598469C>T	uc002tuw.2	-	17	2478	c.2402G>A	c.(2401-2403)GGA>GAA	p.G801E		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	801					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GCTCTCACTTCCCTCTGTGGA	0.428	Ovarian(196;141 2104 8848 24991 25939)		NA											10	49					0	0	0.008291	0	0
THSD7B	80731	broad.mit.edu	37	2	137928425	137928425	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:137928425C>A	uc002tva.1	+	6	1547	c.1547C>A	c.(1546-1548)GCA>GAA	p.A516E	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.A406E	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGATGGCTGGCATCAGAAGGG	0.547			NA											6	29					0.00116845	0.00130265	0.001168	1	0
THSD7B	80731	broad.mit.edu	37	2	138400070	138400071	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:138400070_138400071GG>TT	uc002tva.1	+	20	3725_3726	c.3725_3726GG>TT	c.(3724-3726)CGG>CTT	p.R1242L	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGAATGAGCCGGACTCGATTTA	0.495			NA											11	69					0	0	0.004672	0	0
RIF1	55183	broad.mit.edu	37	2	152293374	152293374	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:152293374C>T	uc002txm.2	+	12	1359	c.1229C>T	c.(1228-1230)CCC>CTC	p.P410L	RIF1_uc002txl.2_Missense_Mutation_p.P410L|RIF1_uc010fnv.1_Missense_Mutation_p.P374L|RIF1_uc002txn.2_Missense_Mutation_p.P410L|RIF1_uc002txo.2_Missense_Mutation_p.P410L|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	410					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CCGGGAACTCCCCGAATGAAC	0.418			NA											6	36					0	0	0.001984	0	0
NEB	4703	broad.mit.edu	37	2	152426643	152426643	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:152426643G>A	uc010fnx.2	-	81	12470	c.12279C>T	c.(12277-12279)GAC>GAT	p.D4093D	NEB_uc002txr.2_Silent_p.D516D	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4093	Nebulin 112.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATCGTTCTGGTCGGGCATGC	0.512			NA											4	14					0	0	0.000602	0	0
NR4A2	4929	broad.mit.edu	37	2	157183359	157183359	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:157183359G>A	uc002tyz.3	-	6	1654	c.1232C>T	c.(1231-1233)ACT>ATT	p.T411I	NR4A2_uc002tyx.3_Missense_Mutation_p.T348I|NR4A2_uc010zcf.1_Missense_Mutation_p.T411I|NR4A2_uc010zcg.1_Missense_Mutation_p.T33I	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	411	Ligand-binding (Potential).				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						CATGGAGCCAGTCAGGAGATC	0.483			NA											18	94					0	0	0.006122	0	0
FAP	2191	broad.mit.edu	37	2	163059565	163059565	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:163059565T>C	uc002ucd.2	-	13	1346	c.1138A>G	c.(1138-1140)ATC>GTC	p.I380V	FAP_uc010zct.1_Missense_Mutation_p.I355V|FAP_uc010fpd.2_Intron	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	380	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GTGTCTTTGATATAGTGAATA	0.348			NA											5	26					0	0	0.000602	0	0
SLC38A11	151258	broad.mit.edu	37	2	165765220	165765220	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:165765220A>T	uc002ucv.1	-	12	1394	c.857T>A	c.(856-858)GTG>GAG	p.V286E	SLC38A11_uc002ucu.1_Missense_Mutation_p.V264E|SLC38A11_uc002ucw.1_Missense_Mutation_p.V286E	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	286	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						GATGACCATCACTGTTACAAC	0.408			NA											7	35					0	0	0.00308	0	0
SCN3A	6328	broad.mit.edu	37	2	165956856	165956856	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:165956856C>T	uc002ucx.2	-	22	4414	c.3922G>A	c.(3922-3924)GCT>ACT	p.A1308T	SCN3A_uc002ucy.2_Missense_Mutation_p.A1259T|SCN3A_uc002ucz.2_Missense_Mutation_p.A1259T|SCN3A_uc002uda.1_Missense_Mutation_p.A1128T|SCN3A_uc002udb.1_Missense_Mutation_p.A1128T	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1308	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GGTCTTAAAGCTCTTAATGTC	0.378			NA											8	53					0	0	0.00308	0	0
SCN2A	6326	broad.mit.edu	37	2	166245431	166245431	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:166245431C>A	uc002udc.2	+	27	5405	c.5115C>A	c.(5113-5115)ATC>ATA	p.I1705I	SCN2A_uc002udd.2_Silent_p.I1705I|SCN2A_uc002ude.2_Silent_p.I1705I	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1705	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ACAGCATGATCTGCCTGTTCC	0.463			NA											27	131					7.26314e-15	1.25745e-14	0.007291	1	0
TTC21B	79809	broad.mit.edu	37	2	166799738	166799738	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:166799738C>G	uc002udk.2	-	5	676	c.543G>C	c.(541-543)CTG>CTC	p.L181L	TTC21B_uc002udl.2_Silent_p.L181L|uc002udm.1_Intron	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	181	TPR 3.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						CCTTACCCAGCAGAGCAAAAG	0.348			NA											4	30					0	0	0.001168	0	0
SCN1A	6323	broad.mit.edu	37	2	166854551	166854551	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:166854551C>G	uc010zcz.1	-	23	4458	c.4440G>C	c.(4438-4440)AAG>AAC	p.K1480N	SCN1A_uc002udo.3_Missense_Mutation_p.K1360N|SCN1A_uc010fpk.2_Missense_Mutation_p.K1332N	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1491	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TACTTATCTTCTTTTTCTGCT	0.318			NA											9	39					0	0	0.008291	0	0
XIRP2	129446	broad.mit.edu	37	2	167992503	167992503	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:167992503G>T	uc002udx.2	+	2	511	c.493G>T	c.(493-495)GAC>TAC	p.D165Y	XIRP2_uc010fpn.2_Missense_Mutation_p.D165Y|XIRP2_uc010fpo.2_Missense_Mutation_p.D165Y|XIRP2_uc010fpp.2_Missense_Mutation_p.D165Y|XIRP2_uc002udy.2_5'UTR	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAAAGATTCAGACAAGAAAGG	0.428			NA											14	48					2.32078e-09	3.57952e-09	0.003163	1	0
XIRP2	129446	broad.mit.edu	37	2	168101996	168101996	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:168101996C>T	uc002udx.2	+	8	4112	c.4094C>T	c.(4093-4095)TCA>TTA	p.S1365L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S1190L|XIRP2_uc010fpq.2_Missense_Mutation_p.S1143L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1190					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATTAATAAATCAGAAACTGTG	0.373			NA											5	39					0	0	0.000602	0	0
ABCB11	8647	broad.mit.edu	37	2	169781254	169781254	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:169781254G>T	uc002ueo.1	-	27	3804	c.3678C>A	c.(3676-3678)CGC>CGA	p.R1226R	ABCB11_uc010zda.1_Silent_p.R644R|ABCB11_uc010zdb.1_Silent_p.R702R	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1226	Cytoplasmic (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CAATAGCAATGCGTTGTTTCT	0.398			NA											7	55					0.00198382	0.00217995	0.001984	1	0
LRP2	4036	broad.mit.edu	37	2	170094714	170094714	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:170094714C>A	uc002ues.2	-	27	4606	c.4393G>T	c.(4393-4395)GGT>TGT	p.G1465C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1465	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATGTAAGAACCATTCTCGACC	0.418			NA											5	48					0.000602214	0.000682885	0.000602	1	0
MYO3B	140469	broad.mit.edu	37	2	171240296	171240296	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:171240296A>G	uc002ufy.2	+	12	1405	c.1262A>G	c.(1261-1263)CAG>CGG	p.Q421R	MYO3B_uc002ufv.2_Missense_Mutation_p.Q408R|MYO3B_uc010fqb.1_Missense_Mutation_p.Q408R|MYO3B_uc002ufz.2_Missense_Mutation_p.Q421R|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	421	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GCTGCTTACCAGTGCATGGTT	0.453			NA											8	48					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179399169	179399169	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179399169C>T	uc010zfg.1	-	307	94693	c.94469G>A	c.(94468-94470)AGG>AAG	p.R31490K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R25185K|TTN_uc010zfi.1_Missense_Mutation_p.R25118K|TTN_uc010zfj.1_Missense_Mutation_p.R24993K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32417							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGAGATTTCCTCTCTTTCAC	0.413			NA											7	63					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179412653	179412653	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179412653T>A	uc010zfg.1	-	288	86220	c.85996A>T	c.(85996-85998)ACC>TCC	p.T28666S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T22361S|TTN_uc010zfi.1_Missense_Mutation_p.T22294S|TTN_uc010zfj.1_Missense_Mutation_p.T22169S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29593							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACGTCAATGGTAAATGGGCTT	0.448			NA											3	23					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179443726	179443726	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179443726G>T	uc010zfg.1	-	269	60551	c.60327C>A	c.(60325-60327)ACC>ACA	p.T20109T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T13804T|TTN_uc010zfi.1_Silent_p.T13737T|TTN_uc010zfj.1_Silent_p.T13612T|uc002umv.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21036							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATATAGTTGGTGATTTCAG	0.478			NA											5	38					0.000602214	0.000682885	0.000602	1	0
TTN	7273	broad.mit.edu	37	2	179578693	179578693	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179578693C>A	uc010zfg.1	-	89	23184	c.22960G>T	c.(22960-22962)GGG>TGG	p.G7654W	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G4315W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8581							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTATACCCCACTGTCACTC	0.428			NA											5	17					0.000602214	0.000682885	0.000602	1	0
TTN	7273	broad.mit.edu	37	2	179622489	179622489	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179622489C>A	uc010zfi.1	-	44	10544	c.10320G>T	c.(10318-10320)GCG>GCT	p.A3440A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133432	NP_597676	Q8WZ42	TITIN_HUMAN	titin isoform novex-1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAAACCCTCGCATGAAATC	0.478			NA											19	69					3.32936e-07	4.67008e-07	0.006122	1	0
PDE1A	5136	broad.mit.edu	37	2	183129074	183129074	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:183129074C>A	uc002uos.2	-	3	253	c.169G>T	c.(169-171)GAA>TAA	p.E57*	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Nonsense_Mutation_p.E57*|PDE1A_uc010zfq.1_Nonsense_Mutation_p.E57*|PDE1A_uc002uor.2_Nonsense_Mutation_p.E41*|PDE1A_uc002uov.1_RNA	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	57					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			GCCGCATATTCAATATTCTTC	0.373			NA											13	43					6.72482e-11	1.08793e-10	0.003163	1	0
DNAJC10	54431	broad.mit.edu	37	2	183582903	183582903	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:183582903G>T	uc002uow.1	+	3	505	c.90G>T	c.(88-90)GTG>GTT	p.V30V	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Silent_p.V30V|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	30					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CCATTTTAGTGGGCACAGATC	0.358	Pancreas(56;860 1183 25669 35822 48585)		NA											7	46					1.06961e-07	1.54041e-07	0.00308	1	0
DNAJC10	54431	broad.mit.edu	37	2	183622484	183622484	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:183622484G>A	uc002uow.1	+	19	2290	c.1875G>A	c.(1873-1875)CAG>CAA	p.Q625Q	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Silent_p.Q579Q|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	625	Thioredoxin 3.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTTGTGCCCAGGAAAACGTTC	0.333	Pancreas(56;860 1183 25669 35822 48585)		NA											12	37					0	0	0.000978	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801171	185801171	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:185801171G>A	uc002uph.2	+	4	1642	c.1048G>A	c.(1048-1050)GGT>AGT	p.G350S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	350						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						ACCTGTTAGTGGTAACAGTTT	0.348			NA											9	37					0	0	0.008291	0	0
COL3A1	1281	broad.mit.edu	37	2	189876477	189876477	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:189876477G>T	uc002uqj.1	+	51	4495	c.4378G>T	c.(4378-4380)GTT>TTT	p.V1460F		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1460	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTGTGGACGTTGGCCCTGT	0.388			NA											8	52					0.000442599	0.000512261	0.006214	1	0
MYO1B	4430	broad.mit.edu	37	2	192288625	192288625	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:192288625A>C	uc010fsg.2	+	31	3605	c.3350A>C	c.(3349-3351)AAT>ACT	p.N1117T	MYO1B_uc002usq.2_Missense_Mutation_p.N1059T|MYO1B_uc002usr.2_Missense_Mutation_p.N1117T|MYO1B_uc002usu.2_Missense_Mutation_p.N362T|MYO1B_uc002usv.2_Missense_Mutation_p.N233T	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	1117						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			AACCAGAAAAATGGGAGTGTC	0.403			NA											16	109					0	0	0.004007	0	0
HECW2	57520	broad.mit.edu	37	2	197185132	197185132	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:197185132T>A	uc002utm.1	-	8	1099	c.916A>T	c.(916-918)AGG>TGG	p.R306W	HECW2_uc002utl.1_Intron	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	306					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GCTGGGAGCCTTCTGCCAAGG	0.463			NA											7	19					0	0	0.00308	0	0
NIF3L1	60491	broad.mit.edu	37	2	201758087	201758087	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:201758087A>T	uc002uwm.2	+	3	646	c.555A>T	c.(553-555)GCA>GCT	p.A185A	NIF3L1_uc002uwl.2_Silent_p.A158A|NIF3L1_uc002uwn.2_Silent_p.A158A|NIF3L1_uc002uwo.2_Silent_p.A185A|NIF3L1_uc002uwp.2_Silent_p.A185A|NIF3L1_uc002uwq.2_Silent_p.A185A	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	185					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						TCATGTCTGCAGTGAAAGGAA	0.398			NA											11	79					0	0	0.001368	0	0
TRAK2	66008	broad.mit.edu	37	2	202245493	202245493	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:202245493T>A	uc002uyb.3	-	16	2964	c.2518A>T	c.(2518-2520)AGA>TGA	p.R840*		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	840				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						ATCCCCAGTCTCTTCAGCCTG	0.512			NA											14	57					0	0	0.00245	0	0
PARD3B	117583	broad.mit.edu	37	2	206364738	206364738	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:206364738G>T	uc002var.1	+	21	3370	c.3163G>T	c.(3163-3165)GAG>TAG	p.E1055*	PARD3B_uc002vao.1_Nonsense_Mutation_p.E954*|PARD3B_uc002vap.1_Nonsense_Mutation_p.E993*|PARD3B_uc002vaq.1_Nonsense_Mutation_p.E986*	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1055					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AAGGCCATCTGAGTATGACCT	0.438			NA											18	93					1.55795e-14	2.68129e-14	0.001882	1	0
LOC200726	200726	broad.mit.edu	37	2	207508998	207508998	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:207508998C>T	uc010fuh.1	+	2	213	c.38C>T	c.(37-39)CCC>CTC	p.P13L		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		ATCCACCGCCCCTTGAGCTTC	0.522			NA											4	15					0	0	0.009096	0	0
DYTN	391475	broad.mit.edu	37	2	207572137	207572137	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:207572137A>T	uc002vbr.1	-	3	302	c.185T>A	c.(184-186)CTT>CAT	p.L62H		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	62						plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TGCCTGAGAAAGTTGCTGCAC	0.537			NA											4	5					0	0	0.009096	0	0
CPS1	1373	broad.mit.edu	37	2	211464127	211464127	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:211464127C>G	uc002vee.3	+	14	1523	c.1391C>G	c.(1390-1392)CCA>CGA	p.P464R	CPS1_uc010fur.2_Missense_Mutation_p.P470R|CPS1_uc010fus.2_Missense_Mutation_p.P13R	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	464					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTGATGAACCCAAACATTGCA	0.398			NA											14	56					0	0	0.004007	0	0
CPS1	1373	broad.mit.edu	37	2	211513207	211513207	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:211513207T>C	uc002vee.3	+	27	3479	c.3347T>C	c.(3346-3348)CTG>CCG	p.L1116P	CPS1_uc010fur.2_Missense_Mutation_p.L1122P|CPS1_uc010fus.2_Missense_Mutation_p.L665P	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1116	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AATGAAGCACTGGAATTTGCA	0.333			NA											8	46					0	0	0.006214	0	0
ERBB4	2066	broad.mit.edu	37	2	212251644	212251644	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:212251644G>T	uc002veg.1	-	27	3513	c.3415C>A	c.(3415-3417)CGG>AGG	p.R1139R	ERBB4_uc002veh.1_Silent_p.R1123R|ERBB4_uc010zji.1_Silent_p.R1129R|ERBB4_uc010zjj.1_Silent_p.R1113R	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1139	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CGTGGGCTCCGTTCTGGGGCA	0.537			NA								TSP Lung(8;0.080)			12	47					6.40141e-05	7.85211e-05	0.000978	1	0
SPAG16	79582	broad.mit.edu	37	2	214204937	214204937	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:214204937G>T	uc002veq.2	+	6	679	c.587G>T	c.(586-588)CGA>CTA	p.R196L	SPAG16_uc010fuz.1_Missense_Mutation_p.R47L|SPAG16_uc002ver.2_Missense_Mutation_p.R142L|SPAG16_uc010zjk.1_Missense_Mutation_p.R102L|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Missense_Mutation_p.R165L	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	196	Potential.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GATTTTCATCGAATGCATCAT	0.284			NA											5	32					3.59834e-05	4.49329e-05	0.001168	1	0
ABCA12	26154	broad.mit.edu	37	2	215914396	215914396	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:215914396G>C	uc002vew.2	-	6	867	c.647C>G	c.(646-648)ACC>AGC	p.T216S	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	216					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTCTAAAAGGGTCATGTTAGA	0.373	Ovarian(66;664 1488 5121 34295)		NA											8	32					0	0	0.004482	0	0
FN1	2335	broad.mit.edu	37	2	216272915	216272915	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:216272915C>T	uc002vfa.2	-	17	2700	c.2434G>A	c.(2434-2436)GAT>AAT	p.D812N	FN1_uc002vfb.2_Missense_Mutation_p.D812N|FN1_uc002vfc.2_Missense_Mutation_p.D812N|FN1_uc002vfd.2_Missense_Mutation_p.D812N|FN1_uc002vfe.2_Missense_Mutation_p.D812N|FN1_uc002vff.2_Missense_Mutation_p.D812N|FN1_uc002vfg.2_Missense_Mutation_p.D812N|FN1_uc002vfh.2_Missense_Mutation_p.D812N|FN1_uc002vfi.2_Missense_Mutation_p.D812N|FN1_uc002vfj.2_Missense_Mutation_p.D812N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	812	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAGGGGCATCAGGCGCTAAG	0.493			NA											10	33					0	0	0.006214	0	0
XRCC5	7520	broad.mit.edu	37	2	217069067	217069067	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:217069067C>G	uc002vfy.2	+	20	2272	c.2132C>G	c.(2131-2133)CCA>CGA	p.P711R	XRCC5_uc002vfz.2_Missense_Mutation_p.P597R	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	711					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AAAGACAAACCAAGTGGAGAC	0.403			NA						Direct_reversal_of_damage|NHEJ					11	52					0	0	0.003163	0	0
CXCR2	3579	broad.mit.edu	37	2	219000380	219000380	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:219000380T>C	uc002vgz.1	+	4	1081	c.856T>C	c.(856-858)TGT>CGT	p.C286R	CXCR2_uc002vha.1_Missense_Mutation_p.C286R|CXCR2_uc002vhb.1_Missense_Mutation_p.C286R	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	286	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CCAGGAGACCTGTGAGCGCCG	0.592			NA											11	62					0	0	0.000978	0	0
SPEG	10290	broad.mit.edu	37	2	220354469	220354469	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:220354469C>A	uc010fwg.2	+	36	8729	c.8729C>A	c.(8728-8730)CCA>CAA	p.P2910Q		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2910	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GTGTCTGCACCACCAGCCCCT	0.622			NA											17	55					1.15088e-07	1.64282e-07	0.004007	1	0
SPEG	10290	broad.mit.edu	37	2	220354645	220354645	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:220354645C>A	uc010fwg.2	+	36	8905	c.8905C>A	c.(8905-8907)CTG>ATG	p.L2969M		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2969	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTACACCTTCCTGGAGGAGAA	0.612			NA											8	17					0.000673444	0.000757755	0.008291	1	0
SLC4A3	6508	broad.mit.edu	37	2	220493218	220493218	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:220493218G>C	uc002vmp.3	+	3	412	c.143G>C	c.(142-144)GGG>GCG	p.G48A	SLC4A3_uc002vmn.2_Missense_Mutation_p.G48A|SLC4A3_uc002vmo.3_Missense_Mutation_p.G48A|SLC4A3_uc010fwm.2_5'UTR	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	48	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCAGGTTTGGGGACCTCATC	0.657			NA											6	24					0	0	0.001168	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882377	228882377	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:228882377G>T	uc002vpq.2	-	7	3240	c.3193C>A	c.(3193-3195)CCC>ACC	p.P1065T	SPHKAP_uc002vpp.2_Missense_Mutation_p.P1065T|SPHKAP_uc010zlx.1_Missense_Mutation_p.P1065T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1065						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGATTCCGGGGATAGCCCTGC	0.562			NA											11	51					0.00185496	0.00205542	0.001855	1	0
PSMD1	5707	broad.mit.edu	37	2	231926996	231926996	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:231926996A>G	uc002vrn.1	+	3	226	c.95A>G	c.(94-96)AAT>AGT	p.N32S	PSMD1_uc002vrm.1_Missense_Mutation_p.N32S|PSMD1_uc010fxu.1_5'UTR	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	32					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	GCAGTTGTTAATGACTTCTGG	0.299			NA											4	15					0	0	0.009096	0	0
PRR21	643905	broad.mit.edu	37	2	240981267	240981267	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:240981267A>T	uc010zod.1	-	1	1133	c.1133T>A	c.(1132-1134)CTT>CAT	p.L378H		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	378										ovary(1)|skin(1)	2						GTTAGAAACAAGAAGACAGGT	0.468			NA											4	35					0	0	0.009096	0	0
OTOS	150677	broad.mit.edu	37	2	241078728	241078728	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:241078728G>T	uc002vyv.2	-	4	284	c.129C>A	c.(127-129)TCC>TCA	p.S43S	MYEOV2_uc002vyu.1_5'Flank|MYEOV2_uc010zof.1_5'Flank	NM_148961	NP_683764	Q8NHW6	OTOSP_HUMAN	otospiralin precursor	43						extracellular region					0		all_epithelial(40;2.79e-15)|Breast(86;3.04e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|Hepatocellular(293;0.148)|all_hematologic(139;0.158)|Melanoma(123;0.16)		Epithelial(32;2.56e-30)|all cancers(36;7.18e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.37e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.07e-06)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		AGTCAGAGGTGGAGAAAGGCC	0.617			NA											15	66					0.000422831	0.00049212	0.004007	1	0
RNPEPL1	57140	broad.mit.edu	37	2	241513651	241513651	+	Missense_Mutation	SNP	G	G	C	rs139059683		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:241513651G>C	uc002vzi.2	+	5	960	c.367G>C	c.(367-369)GAG>CAG	p.E123Q	RNPEPL1_uc010fzf.2_5'UTR|RNPEPL1_uc002vzj.2_5'Flank	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	123		Proton acceptor (By similarity).			leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		TGTCATCCACGAGGTGGCCCA	0.607			NA											8	51					0	0	0.004482	0	0
PASK	23178	broad.mit.edu	37	2	242079351	242079351	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:242079351G>T	uc002wao.1	-	4	641	c.549C>A	c.(547-549)AGC>AGA	p.S183R	PASK_uc010zol.1_Intron|PASK_uc010zom.1_Missense_Mutation_p.S183R|PASK_uc010fzl.1_Missense_Mutation_p.S183R|PASK_uc010zon.1_Intron|PASK_uc002waq.2_Missense_Mutation_p.S183R	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	183	PAS 1.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TGTGCTCCTCGCTGAGGGCCT	0.617			NA											4	23					0.000602214	0.000682885	0.000602	1	0
D2HGDH	728294	broad.mit.edu	37	2	242689675	242689675	+	Silent	SNP	C	C	G	rs141524359		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:242689675C>G	uc002wce.1	+	7	1136	c.963C>G	c.(961-963)GTC>GTG	p.V321V	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Silent_p.V187V|D2HGDH_uc002wcg.1_Intron|D2HGDH_uc002wch.2_RNA|D2HGDH_uc002wci.2_Silent_p.V20V	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	321					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TGCAGCTGGTCGGGCGCCATC	0.612			NA											7	39					0	0	0.008291	0	0
NEU4	129807	broad.mit.edu	37	2	242758367	242758367	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:242758367C>A	uc010fzr.2	+	4	1534	c.1448C>A	c.(1447-1449)CCC>CAC	p.P483H	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.P483H|NEU4_uc002wcn.1_Missense_Mutation_p.P495H|NEU4_uc002wco.1_Missense_Mutation_p.P483H|NEU4_uc002wcp.1_Missense_Mutation_p.P495H	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	483						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		TGCTGCTGGCCCTCCTGACAG	0.657			NA											3	9					2.56e-06	3.4196e-06	0.009096	1	0
FERMT1	55612	broad.mit.edu	37	20	6068532	6068532	+	Splice_Site	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:6068532T>A	uc002wmr.2	-	11	2054	c.1265_splice	c.e11-1	p.G422_splice	FERMT1_uc002wmq.2_Splice_Site|FERMT1_uc010gbt.2_Splice_Site_p.G165_splice|FERMT1_uc002wms.2_Intron	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1						cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						CTTCGCAGCCTGAAGGACAAA	0.393			NA											10	44					0	0	0.006214	0	0
FERMT1	55612	broad.mit.edu	37	20	6096636	6096636	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:6096636C>T	uc002wmr.2	-	3	996	c.207G>A	c.(205-207)TGG>TGA	p.W69*	FERMT1_uc010gbt.2_5'UTR|FERMT1_uc002wms.2_Nonsense_Mutation_p.W69*	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	69					cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						TTTTCAGAAGCCAGCAATGCT	0.483			NA											6	25					0	0	0.001168	0	0
PAK7	57144	broad.mit.edu	37	20	9560984	9560984	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:9560984C>A	uc002wnl.2	-	5	1343	c.798G>T	c.(796-798)AGG>AGT	p.R266S	PAK7_uc002wnk.2_Missense_Mutation_p.R266S|PAK7_uc002wnj.2_Missense_Mutation_p.R266S|PAK7_uc010gby.1_Missense_Mutation_p.R266S	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	266	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ACTTTGGCCTCCTGTCATAGT	0.567			NA											11	40					1.58986e-06	2.14735e-06	0.008291	1	0
PAK7	57144	broad.mit.edu	37	20	9560986	9560986	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:9560986T>A	uc002wnl.2	-	5	1341	c.796A>T	c.(796-798)AGG>TGG	p.R266W	PAK7_uc002wnk.2_Missense_Mutation_p.R266W|PAK7_uc002wnj.2_Missense_Mutation_p.R266W|PAK7_uc010gby.1_Missense_Mutation_p.R266W	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	266	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TTTGGCCTCCTGTCATAGTCA	0.572			NA											11	41					0	0	0.008291	0	0
PCSK2	5126	broad.mit.edu	37	20	17434420	17434420	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:17434420G>T	uc002wpm.2	+	9	1239	c.919G>T	c.(919-921)GCC>TCC	p.A307S	PCSK2_uc002wpl.2_Missense_Mutation_p.A288S|PCSK2_uc010zrm.1_Missense_Mutation_p.A272S	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	307	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTACGTGTGGGCCTCCGGGGA	0.677			NA											8	35					0.000274275	0.000319476	0.004482	1	0
FRG1B	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:29625934C>T	uc010ztl.1	+	2	120	c.88C>T	c.(88-90)CAT>TAT	p.H30Y	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ACTTGTTGGGCATTCAGATGC	0.338			NA											5	48					0	0	0.004482	0	0
DEFB118	117285	broad.mit.edu	37	20	29960763	29960763	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:29960763C>G	uc002wvr.2	+	2	188	c.162C>G	c.(160-162)TGC>TGG	p.C54W		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	54					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TTCGAGCTTGCTGCATTCCAT	0.428			NA											18	51					0	0	0.00499	0	0
XKR7	343702	broad.mit.edu	37	20	30556125	30556125	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:30556125G>C	uc002wxe.2	+	1	321	c.147G>C	c.(145-147)GGG>GGC	p.G49G		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	49						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			gcggcccggggccgcgcTACG	0.443			NA											3	8					0	0	0.009096	0	0
PLAGL2	5326	broad.mit.edu	37	20	30789751	30789751	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:30789751C>T	uc002wxn.2	-	2	448	c.231G>A	c.(229-231)AAG>AAA	p.K77K		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	77	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAGCAAAAGCCTTGCCACAGT	0.522	Colon(163;15 1893 11280 16306 47518)		NA											9	47					0	0	0.006214	0	0
COMMD7	149951	broad.mit.edu	37	20	31292637	31292637	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:31292637C>A	uc002wya.3	-	6	1023	c.406G>T	c.(406-408)GAT>TAT	p.D136Y	COMMD7_uc010ged.2_Missense_Mutation_p.D135Y|COMMD7_uc002wyb.2_Missense_Mutation_p.D136Y	NM_053041	NP_444269	Q86VX2	COMD7_HUMAN	COMM domain containing 7 isoform 1	136	COMM.				negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|tumor necrosis factor-mediated signaling pathway		NF-kappaB binding			breast(1)	1						CACTCCATATCTATGAGCTGG	0.478			NA											5	52					8.12818e-05	9.82943e-05	0.001984	1	0
COMMD7	149951	broad.mit.edu	37	20	31294522	31294522	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:31294522C>T	uc002wya.3	-	4	899	c.282G>A	c.(280-282)GCG>GCA	p.A94A	COMMD7_uc010ged.2_Silent_p.A93A|COMMD7_uc002wyb.2_Silent_p.A94A	NM_053041	NP_444269	Q86VX2	COMD7_HUMAN	COMM domain containing 7 isoform 1	94					negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|tumor necrosis factor-mediated signaling pathway		NF-kappaB binding			breast(1)	1						TTATGAAATCCGCCTGGACCT	0.473			NA											8	28					0	0	0.004482	0	0
BPIL1	80341	broad.mit.edu	37	20	31601738	31601738	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:31601738C>A	uc002wyj.2	+	5	625	c.431C>A	c.(430-432)GCC>GAC	p.A144D		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	144						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						TCGGGCCACGCCAACGAGTTT	0.597			NA											5	16					0.00198382	0.00217995	0.001984	1	0
C20orf186	149954	broad.mit.edu	37	20	31671451	31671451	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:31671451C>A	uc010zue.1	+	3	463	c.448C>A	c.(448-450)CGA>AGA	p.R150R		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	150	Gly-rich.					cytoplasm|extracellular region	lipid binding				0						GCTTCACCGGCGAGAGCTGCA	0.642			NA											7	36					2.0095e-06	2.69165e-06	0.001984	1	0
GGT7	2686	broad.mit.edu	37	20	33440034	33440034	+	Missense_Mutation	SNP	G	G	A	rs142938362	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:33440034G>A	uc002xay.2	-	12	1554	c.1511C>T	c.(1510-1512)TCG>TTG	p.S504L	GGT7_uc010gex.2_5'Flank|GGT7_uc002xaz.1_Missense_Mutation_p.S521L	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	504	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						CAGGATCCCCGAGGGGGTGAT	0.642			NA											8	26					0	0	0.00308	0	0
ERGIC3	51614	broad.mit.edu	37	20	34144838	34144838	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:34144838A>G	uc002xct.2	+	11	1043	c.974A>G	c.(973-975)TAT>TGT	p.Y325C	ERGIC3_uc002xcs.2_Missense_Mutation_p.Y330C|ERGIC3_uc002xcu.2_Missense_Mutation_p.Y340C|ERGIC3_uc002xcv.2_Missense_Mutation_p.Y288C	NM_015966	NP_057050	Q9Y282	ERGI3_HUMAN	serologically defined breast cancer antigen 84	325	Lumenal (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			large_intestine(2)|ovary(1)	3	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TTCGTCCTCTATGAGCTCTCG	0.602			NA											4	45					0	0	0.009096	0	0
EPB41L1	2036	broad.mit.edu	37	20	34797560	34797560	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:34797560A>G	uc002xfb.2	+	15	1990	c.1819A>G	c.(1819-1821)AGC>GGC	p.S607G	EPB41L1_uc002xeu.2_Missense_Mutation_p.S533G|EPB41L1_uc010zvo.1_Missense_Mutation_p.S607G|EPB41L1_uc002xev.2_Missense_Mutation_p.S607G|EPB41L1_uc002xew.2_Missense_Mutation_p.S498G|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Missense_Mutation_p.S533G|EPB41L1_uc010gfq.2_Missense_Mutation_p.S706G	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	607					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CAAGTGCTCCAGCATCACGGT	0.607			NA											5	22					0	0	0.001168	0	0
C20orf132	140699	broad.mit.edu	37	20	35740727	35740727	+	Silent	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:35740727A>G	uc010zvu.1	-	23	2935	c.2844T>C	c.(2842-2844)TTT>TTC	p.F948F	C20orf132_uc002xgk.2_Silent_p.F570F	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:Variant_position_missing_in_Q9H579_after_alignment											0		Myeloproliferative disorder(115;0.00878)				GCTCACATACAAAGAATCTGC	0.418			NA											10	55					0	0	0.001855	0	0
TOP1	7150	broad.mit.edu	37	20	39721125	39721125	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:39721125C>A	uc002xjl.2	+	9	874	c.628C>A	c.(628-630)CGC>AGC	p.R210S	TOP1_uc010gge.1_RNA	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	210					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	GGAAGAAGAGCGCTATCCTGA	0.413			NA	T	NUP98	AML*								12	44					0.00185496	0.00205542	0.001855	1	0
IFT52	51098	broad.mit.edu	37	20	42242616	42242616	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:42242616G>T	uc002xkw.2	+	7	734	c.612G>T	c.(610-612)AAG>AAT	p.K204N	IFT52_uc010zwi.1_RNA|IFT52_uc002xky.2_Missense_Mutation_p.K204N|IFT52_uc002xkx.2_RNA|IFT52_uc010ggn.2_Missense_Mutation_p.K180N|IFT52_uc002xkz.2_Missense_Mutation_p.K204N	NM_016004	NP_057088	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog	204						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			ovary(2)	2		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATCACTCAAAGGTACAGCTTT	0.388			NA											12	47					4.93089e-13	8.29986e-13	0.00245	1	0
TOX2	84969	broad.mit.edu	37	20	42635430	42635430	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:42635430A>T	uc002xlf.3	+	3	453	c.436A>T	c.(436-438)ACG>TCG	p.T146S	TOX2_uc010ggo.2_Missense_Mutation_p.T137S|TOX2_uc002xle.3_Missense_Mutation_p.T95S|TOX2_uc010ggp.2_Missense_Mutation_p.T95S|TOX2_uc002xlg.2_Missense_Mutation_p.T95S	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCAGCTGCCCACGGTGAGTCC	0.572			NA											4	13					0	0	0.000602	0	0
ZNF335	63925	broad.mit.edu	37	20	44596133	44596133	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:44596133C>T	uc002xqw.2	-	6	1078	c.955G>A	c.(955-957)GAG>AAG	p.E319K	ZNF335_uc010zxk.1_Missense_Mutation_p.E164K|ZNF335_uc002xqx.1_Missense_Mutation_p.E287K|ZNF335_uc002xqy.2_Missense_Mutation_p.G164S	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GGTGGCCTACCCTCCAGGTCA	0.542			NA											9	41					0	0	0.008291	0	0
MMP9	4318	broad.mit.edu	37	20	44641127	44641127	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:44641127C>A	uc002xqz.2	+	8	1255	c.1236C>A	c.(1234-1236)TCC>TCA	p.S412S		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	412					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TAGATCATTCCTCAGTGCCGG	0.622			NA											8	56					7.48243e-07	1.03265e-06	0.006214	1	0
SLC12A5	57468	broad.mit.edu	37	20	44671910	44671910	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:44671910T>C	uc010zxl.1	+	9	1330	c.1254T>C	c.(1252-1254)GAT>GAC	p.D418D	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Silent_p.D395D	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	418	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCTTCAGTGATATGACCTCCT	0.572			NA											51	180					0	0	0.00361	0	0
SLC13A3	64849	broad.mit.edu	37	20	45194872	45194872	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:45194872T>C	uc002xsf.1	-	11	1528	c.1490A>G	c.(1489-1491)GAG>GGG	p.E497G	SLC13A3_uc010ghn.1_Missense_Mutation_p.E466G|SLC13A3_uc010zxw.1_Missense_Mutation_p.E447G|SLC13A3_uc002xsg.1_Missense_Mutation_p.E450G|SLC13A3_uc010gho.1_Missense_Mutation_p.E415G|SLC13A3_uc010zxx.1_Missense_Mutation_p.E399G|SLC13A3_uc002xse.1_5'Flank|SLC13A3_uc010ghm.1_Missense_Mutation_p.E84G|SLC13A3_uc010zxv.1_Missense_Mutation_p.E82G	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	497	Extracellular (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CCTCACCAGCTCTGCCAGGAC	0.607			NA											18	71					0	0	0.010504	0	0
CSE1L	1434	broad.mit.edu	37	20	47691870	47691870	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:47691870G>C	uc002xty.2	+	12	1282	c.1148G>C	c.(1147-1149)CGC>CCC	p.R383P	CSE1L_uc010zyg.1_Missense_Mutation_p.R166P|CSE1L_uc010ghx.2_Missense_Mutation_p.R327P|CSE1L_uc010ghy.2_Missense_Mutation_p.R32P|CSE1L_uc010zyh.1_Missense_Mutation_p.R32P	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	383					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			GATACTAGACGCAGGGCTGCT	0.373			NA											13	49					0	0	0.003163	0	0
KCNB1	3745	broad.mit.edu	37	20	47989936	47989936	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:47989936G>T	uc002xur.1	-	2	2325	c.2161C>A	c.(2161-2163)CCA>ACA	p.P721T	KCNB1_uc002xus.1_Missense_Mutation_p.P721T	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	721	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAGGACTCTGGGCTCAGCACA	0.582			NA											12	31					4.36969e-10	6.88557e-10	0.001855	1	0
KCNG1	3755	broad.mit.edu	37	20	49626751	49626751	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:49626751C>T	uc002xwa.3	-	2	420	c.125G>A	c.(124-126)CGG>CAG	p.R42Q	KCNG1_uc002xwb.2_Missense_Mutation_p.R42Q	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	42	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						CCGCTGCGCCCGGCGGTAGAA	0.692			NA											11	27					0	0	0.000978	0	0
SALL4	57167	broad.mit.edu	37	20	50407808	50407808	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:50407808G>T	uc002xwh.3	-	2	1315	c.1214C>A	c.(1213-1215)ACT>AAT	p.T405N	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	405					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCTCTCTCCAGTGTGGGAGCG	0.542			NA											8	37					1.06961e-07	1.54041e-07	0.00308	1	0
TSHZ2	128553	broad.mit.edu	37	20	51870390	51870390	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:51870390C>A	uc002xwo.2	+	2	1349	c.393C>A	c.(391-393)AAC>AAA	p.N131K		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	131					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TCTACGCCAACATCCTGTCGG	0.527			NA											7	21					2.0095e-06	2.69165e-06	0.001984	1	0
TSHZ2	128553	broad.mit.edu	37	20	51871070	51871070	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:51871070A>C	uc002xwo.2	+	2	2029	c.1073A>C	c.(1072-1074)AAC>ACC	p.N358T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	358					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TCCTCCAACAACCGCTATGGC	0.502			NA											14	65					0	0	0.00245	0	0
C20orf85	128602	broad.mit.edu	37	20	56728608	56728608	+	Missense_Mutation	SNP	G	G	T	rs16984945	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:56728608G>T	uc002xyv.2	+	2	115	c.77G>T	c.(76-78)CGT>CTT	p.R26L		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	26										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			AGGAAATACCGTCTGAAGGCT	0.483			NA											25	116					3.65163e-15	6.37502e-15	0.00632	1	0
ZNF831	128611	broad.mit.edu	37	20	57766700	57766700	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:57766700C>T	uc002yan.2	+	1	626	c.626C>T	c.(625-627)GCC>GTC	p.A209V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	209						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCCGAGGGCGCCGGGGGCGGC	0.677			NA											15	50					0	0	0.00499	0	0
EDN3	1908	broad.mit.edu	37	20	57896099	57896099	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:57896099C>A	uc002yap.2	+	3	762	c.393C>A	c.(391-393)AAC>AAA	p.N131K	EDN3_uc002yao.1_Missense_Mutation_p.N131K|EDN3_uc002yaq.2_Missense_Mutation_p.N131K|EDN3_uc002yar.2_Missense_Mutation_p.N131K|EDN3_uc002yas.2_Missense_Mutation_p.N131K	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	131					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					GACTGTCCAACTACAGAGGAA	0.612			NA											10	42					0.000978159	0.00109807	0.000978	1	0
SYCP2	10388	broad.mit.edu	37	20	58490245	58490245	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:58490245C>A	uc002yaz.2	-	9	748	c.609G>T	c.(607-609)ATG>ATT	p.M203I	SYCP2_uc010gju.1_Missense_Mutation_p.M104I	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	203					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCCTTTCTCCCATACTACTCC	0.279			NA											17	102					1.99824e-07	2.83847e-07	0.00499	1	0
CDH4	1002	broad.mit.edu	37	20	60419857	60419857	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:60419857G>T	uc002ybn.1	+	5	724	c.710G>T	c.(709-711)CGG>CTG	p.R237L	CDH4_uc002ybp.1_Missense_Mutation_p.R163L	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	237	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCCATGGACCGGGAGGAGCAC	0.662			NA											7	13					0.00448238	0.00486678	0.004482	1	0
HRH3	11255	broad.mit.edu	37	20	60791954	60791954	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:60791954G>T	uc002ycf.2	-	3	743	c.446C>A	c.(445-447)ACG>AAG	p.T149K	HRH3_uc002ycg.2_Missense_Mutation_p.T149K|HRH3_uc002ych.2_Missense_Mutation_p.T149K|HRH3_uc002yci.2_Missense_Mutation_p.T149K	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	149	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	TGCCCGCCGCGTGTCACCCTG	0.682			NA											3	21					0.000602214	0.000682885	0.000602	1	0
STMN3	50861	broad.mit.edu	37	20	62273466	62273466	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:62273466C>T	uc002yfr.1	-	4	560	c.478G>A	c.(478-480)GAG>AAG	p.E160K	STMN3_uc011abb.1_Missense_Mutation_p.E160K	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	160	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			CGCACCTTCTCGCGCAGCCGC	0.368			NA											5	8					0	0	0.000602	0	0
BAGE2	85319	broad.mit.edu	37	21	11049609	11049609	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:11049609G>T	uc002yit.1	-	4	500	c.292C>A	c.(292-294)CAA>AAA	p.Q98K		NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGCACAGTTTGCATCTTCCTT	0.378			NA											8	122					5.4927e-09	8.34799e-09	0.004482	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28315712	28315712	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:28315712C>T	uc002ymg.2	-	3	2121	c.1392G>A	c.(1390-1392)CTG>CTA	p.L464L		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	464	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GGCCATCATCCAGGAATTCTG	0.403	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											11	13					0	0	0.008291	0	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709507	31709507	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:31709507T>G	uc002ynx.1	-	1	506	c.480A>C	c.(478-480)CAA>CAC	p.Q160H		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	160						intermediate filament				ovary(2)	2						GACACTGACATTGGCTAGATG	0.493			NA											12	90					0	0	0.000978	0	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802904	31802904	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:31802904C>A	uc011acw.1	+	1	311	c.311C>A	c.(310-312)TCG>TAG	p.S104*		NM_181600	NP_853631	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	104						intermediate filament					0						TGCTGCTACTCGCTGGGAAAT	0.527	NSCLC(196;2401 3038 18004 35753)		NA											11	14					6.40141e-05	7.85211e-05	0.000978	1	0
KRTAP19-4	337971	broad.mit.edu	37	21	31869266	31869266	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:31869266C>A	uc011acz.1	-	1	163	c.163G>T	c.(163-165)GGA>TGA	p.G55*		NM_181610	NP_853641	Q3LI73	KR194_HUMAN	keratin associated protein 19-4	55						intermediate filament				ovary(2)	2						CCATATCCTCCATAGCATGAT	0.463			NA											32	74					1.836e-18	3.3541e-18	0.003755	1	0
MX2	4600	broad.mit.edu	37	21	42778787	42778787	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:42778787G>A	uc002yzf.1	+	13	1871	c.1767G>A	c.(1765-1767)CTG>CTA	p.L589L	MX2_uc002yzg.1_Silent_p.L312L|MX2_uc010gop.1_Silent_p.L71L	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	589					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GTGTTGTTCTGAAGAAAGTCC	0.403			NA											8	56					0	0	0.006214	0	0
MX1	4599	broad.mit.edu	37	21	42824753	42824753	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:42824753C>G	uc002yzh.2	+	18	2662	c.1715C>G	c.(1714-1716)TCT>TGT	p.S572C	MX1_uc002yzi.2_Missense_Mutation_p.S572C|MX1_uc010goq.2_Missense_Mutation_p.S572C	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	572					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GCAACAGACTCTTCCATGGAG	0.502			NA											35	148					0	0	0.006999	0	0
UMODL1	89766	broad.mit.edu	37	21	43531672	43531672	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:43531672C>A	uc002zaf.1	+	12	1956	c.1956C>A	c.(1954-1956)CCC>CCA	p.P652P	UMODL1_uc002zad.1_Silent_p.P580P|UMODL1_uc002zae.1_Silent_p.P708P|UMODL1_uc002zag.1_Silent_p.P780P	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	652	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CTGAGGACCCCACCGGCCACT	0.627	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											5	35					1.23904e-05	1.57558e-05	0.000602	1	0
ITGB2	3689	broad.mit.edu	37	21	46308663	46308663	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr21:46308663C>A	uc002zgd.2	-	13	2069	c.2025G>T	c.(2023-2025)ACG>ACT	p.T675T	ITGB2_uc002zge.2_Silent_p.T675T|ITGB2_uc002zgf.3_Silent_p.T675T|ITGB2_uc011afl.1_Silent_p.T597T|ITGB2_uc010gpw.2_Silent_p.T618T|ITGB2_uc002zgg.2_Silent_p.T675T	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	675	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCTGCTCCAGCGTGTAGGCCA	0.677			NA											8	33					0.00621372	0.00666704	0.006214	1	0
POTEH	23784	broad.mit.edu	37	22	16287779	16287779	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:16287779C>A	uc010gqp.2	-	1	159	c.107G>T	c.(106-108)AGG>ATG	p.R36M	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Translation_Start_Site	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	36										skin(1)	1						GCCGCTCCCCCTGCACCAGGC	0.587			NA											12	145					2.27111e-07	3.21042e-07	0.001368	1	0
MED15	51586	broad.mit.edu	37	22	20891465	20891465	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:20891465C>T	uc002zsp.2	+	2	210	c.130C>T	c.(130-132)CAT>TAT	p.H44Y	MED15_uc002zsn.1_5'UTR|MED15_uc002zso.2_Missense_Mutation_p.H44Y|MED15_uc002zsq.2_Missense_Mutation_p.H44Y|MED15_uc010gso.2_Missense_Mutation_p.H44Y|MED15_uc002zsr.2_Missense_Mutation_p.H18Y|MED15_uc011ahs.1_Missense_Mutation_p.H18Y|MED15_uc011aht.1_Missense_Mutation_p.H18Y	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	44	Interaction with SREBF1.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TATGGAGAGCCATGTTTTCCT	0.527			NA											5	15					0	0	0.001984	0	0
LZTR1	8216	broad.mit.edu	37	22	21348288	21348288	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:21348288G>C	uc002zto.2	+	13	1532	c.1429G>C	c.(1429-1431)GCG>CCG	p.A477P	LZTR1_uc002ztn.2_Missense_Mutation_p.A436P|LZTR1_uc011ahy.1_Missense_Mutation_p.A458P|LZTR1_uc010gsr.1_Missense_Mutation_p.A348P|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	477	BTB 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GATCACGCAGGCGCGGGAGAG	0.647			NA											5	11					0	0	0.001168	0	0
HPS4	89781	broad.mit.edu	37	22	26872994	26872994	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:26872994T>A	uc003acl.2	-	4	900	c.241A>T	c.(241-243)AAG>TAG	p.K81*	HPS4_uc003aci.2_Nonsense_Mutation_p.K76*|HPS4_uc003acj.2_5'UTR|HPS4_uc003ack.2_5'UTR|HPS4_uc003acn.2_5'UTR|HPS4_uc010gvd.1_Nonsense_Mutation_p.K81*|HPS4_uc003aco.1_Nonsense_Mutation_p.K76*	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	81					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						ATGGCAAACTTCAGTTTTCTC	0.413			NA							Hermansky-Pudlak_syndrome				14	22					0	0	0.004007	0	0
APOL3	80833	broad.mit.edu	37	22	36556806	36556806	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:36556806C>T	uc003aot.2	-	1	172	c.134G>A	c.(133-135)GGT>GAT	p.G45D	APOL3_uc003aoq.2_5'UTR|APOL3_uc003aor.2_5'UTR|APOL3_uc003aos.2_5'UTR|APOL3_uc003aou.2_5'UTR|APOL3_uc003aov.2_5'UTR	NM_145640	NP_663615	O95236	APOL3_HUMAN	apolipoprotein L3 isoform 1	45					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity				0						TGCATAATAACCAGACACGTT	0.488			NA											8	40					0	0	0.004482	0	0
CACNA1I	8911	broad.mit.edu	37	22	40068257	40068257	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:40068257G>A	uc003ayc.2	+	27	4593	c.4593G>A	c.(4591-4593)GTG>GTA	p.V1531V	CACNA1I_uc003ayd.2_Silent_p.V1496V|CACNA1I_uc003aye.2_Silent_p.V1446V|CACNA1I_uc003ayf.2_Silent_p.V1411V	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1531	Helical; Name=S2 of repeat IV; (Potential).|IV.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTGTCTTTGTGCTGGAGGCTG	0.532			NA											47	120					0	0	0.00361	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283562	40283562	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:40283562T>A	uc003ayg.2	-	2	442	c.191A>T	c.(190-192)CAT>CTT	p.H64L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	64	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GTTCTTCCCATGGTCATTGAG	0.418			NA											24	82					0	0	0.00333	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41737150	41737150	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:41737150G>A	uc003azw.2	+	11	1413	c.1197G>A	c.(1195-1197)TCG>TCA	p.S399S	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	415					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CAGCCCCCTCGGTGAGTGACT	0.612			NA											7	23					0	0	0.00308	0	0
XRCC6	2547	broad.mit.edu	37	22	42024183	42024183	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:42024183G>A	uc003bao.1	+	3	214	c.144G>A	c.(142-144)ATG>ATA	p.M48I	XRCC6_uc003bap.1_Missense_Mutation_p.M48I|XRCC6_uc011apc.1_Intron|XRCC6_uc003baq.1_Missense_Mutation_p.M48I|XRCC6_uc003bar.1_Missense_Mutation_p.M48I|XRCC6_uc003bas.1_Intron	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	48	Ser-rich (potentially targets for phosphorylation).				DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						CCAAGGCTATGTTTGAATCTC	0.323			NA						Direct_reversal_of_damage|NHEJ					18	27					0	0	0.00278	0	0
PNPLA5	150379	broad.mit.edu	37	22	44282278	44282278	+	Missense_Mutation	SNP	C	C	T	rs144693499	by1000genomes	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:44282278C>T	uc003beg.2	-	6	951	c.854G>A	c.(853-855)CGC>CAC	p.R285H	PNPLA5_uc011aqc.1_Missense_Mutation_p.R145H|PNPLA5_uc003beh.2_Missense_Mutation_p.R171H	NM_138814	NP_620169	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	285					lipid catabolic process		hydrolase activity				0		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CCCCTTCCAGCGTTGGTCACA	0.592			NA											13	22					0	0	0.001855	0	0
CELSR1	9620	broad.mit.edu	37	22	46787142	46787142	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:46787142C>T	uc003bhw.1	-	16	6191	c.6191G>A	c.(6190-6192)TGG>TAG	p.W2064*	CELSR1_uc011arc.1_Nonsense_Mutation_p.W385*	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2064	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTGTGGCCACCAGATGCCGGC	0.612			NA									OREG0026656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	23					0	0	0.008291	0	0
CERK	64781	broad.mit.edu	37	22	47087660	47087660	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:47087660A>T	uc003bia.2	-	11	1248	c.1141T>A	c.(1141-1143)TGG>AGG	p.W381R	CERK_uc010hae.2_Missense_Mutation_p.W183R	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	381					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACGACTTGCCACTCCTCCACG	0.627			NA											8	10					0	0	0.004482	0	0
CNTN4	152330	broad.mit.edu	37	3	2967317	2967317	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:2967317A>T	uc003bpc.2	+	12	1433	c.1212A>T	c.(1210-1212)GTA>GTT	p.V404V	CNTN4_uc003bpb.1_Silent_p.V76V|CNTN4_uc003bpd.1_Silent_p.V404V|CNTN4_uc003bpe.2_Silent_p.V76V|CNTN4_uc003bpf.2_Silent_p.V76V	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	404					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TTTCAGCTGTAGGTCCAGATT	0.323			NA											26	51					0	0	0.005443	0	0
LRRN1	57633	broad.mit.edu	37	3	3887744	3887744	+	Silent	SNP	A	A	T	rs150270030	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:3887744A>T	uc003bpt.3	+	2	2180	c.1419A>T	c.(1417-1419)TCA>TCT	p.S473S	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	473	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AAACCCTTTCAGATAAATACA	0.438			NA											23	58					0	0	0.00278	0	0
ITPR1	3708	broad.mit.edu	37	3	4711404	4711404	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:4711404G>T	uc003bqa.2	+	19	2301	c.1953G>T	c.(1951-1953)CTG>CTT	p.L651L	ITPR1_uc010hca.1_Silent_p.L636L|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Silent_p.L636L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	651	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CCCAGGAACTGATATGTAAAG	0.443			NA											4	11					0.00024832	0.000292993	0.009096	1	0
OXTR	5021	broad.mit.edu	37	3	8809287	8809287	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:8809287C>A	uc003brc.2	-	3	1209	c.587G>T	c.(586-588)GGA>GTA	p.G196V		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	196	Extracellular (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GGCCTTGGGTCCCCAGGGCTG	0.627			NA											7	31					1.12685e-05	1.44938e-05	0.004482	1	0
CIDEC	63924	broad.mit.edu	37	3	9911858	9911858	+	Missense_Mutation	SNP	G	G	T	rs145091411		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:9911858G>T	uc003btq.2	-	4	496	c.356C>A	c.(355-357)CCA>CAA	p.P119Q	CIDEC_uc003bto.2_Intron|CIDEC_uc010hcp.2_Intron|CIDEC_uc003btp.2_Missense_Mutation_p.P129Q|CIDEC_uc003btr.2_Missense_Mutation_p.P45Q|CIDEC_uc003bts.2_Missense_Mutation_p.P45Q	NM_022094	NP_071377	Q96AQ7	CIDEC_HUMAN	cell death-inducing DFFA-like effector c	119					apoptosis|induction of apoptosis	cytosol|focal adhesion|nucleus				central_nervous_system(1)	1	Medulloblastoma(99;0.227)					CTGTTCTGATGGGGGCTGCCA	0.532			NA											18	38					3.41278e-10	5.41287e-10	0.00499	1	0
FGD5	152273	broad.mit.edu	37	3	14905750	14905750	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:14905750C>A	uc003bzc.2	+	2	2751	c.2641C>A	c.(2641-2643)CCC>ACC	p.P881T	FGD5_uc011avk.1_Missense_Mutation_p.P881T	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	881					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						TTCAAGAGACCCCAGTGTCAC	0.587			NA											9	30					0.000274275	0.000319476	0.004482	1	0
COLQ	8292	broad.mit.edu	37	3	15499752	15499752	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:15499752C>A	uc003bzx.2	-	13	1021	c.895G>T	c.(895-897)GTG>TTG	p.V299L	COLQ_uc003bzv.2_Missense_Mutation_p.V289L|COLQ_uc003bzz.2_Missense_Mutation_p.V290L|COLQ_uc010heo.2_Missense_Mutation_p.V265L|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Missense_Mutation_p.V158L|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	299					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						GGGTTATTCACATTCATAGTG	0.522			NA											20	56					5.35356e-11	8.68983e-11	0.00278	1	0
SATB1	6304	broad.mit.edu	37	3	18427954	18427954	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:18427954C>A	uc003cbh.2	-	8	3091	c.1356G>T	c.(1354-1356)TTG>TTT	p.L452F	SATB1_uc003cbi.2_Missense_Mutation_p.L452F|SATB1_uc003cbj.2_Missense_Mutation_p.L452F	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	452					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						AGGCAGCATTCAAGCTCCTTT	0.547			NA											19	61					2.4624e-09	3.79391e-09	0.008871	1	0
RAB5A	5868	broad.mit.edu	37	3	20017161	20017161	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:20017161G>C	uc003cbn.2	+	3	767	c.232G>C	c.(232-234)GGT>CGT	p.G78R	RAB5A_uc010hey.2_RNA|RAB5A_uc011awg.1_Missense_Mutation_p.G64R	NM_004162	NP_004153	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	78	GTP.				blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0						GGATACAGCTGGTCAAGAACG	0.383			NA											17	33					0	0	0.004007	0	0
CCR4	1233	broad.mit.edu	37	3	32995815	32995815	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:32995815C>A	uc003cfg.1	+	2	1069	c.901C>A	c.(901-903)CCC>ACC	p.P301T		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	301	Helical; Name=7; (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						CTGCCTTAATCCCATCATCTA	0.478			NA											15	38					3.27435e-08	4.82536e-08	0.00245	1	0
CLASP2	23122	broad.mit.edu	37	3	33557609	33557609	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:33557609C>T	uc003cfu.2	-	35	4370	c.4016G>A	c.(4015-4017)AGA>AAA	p.R1339K	CLASP2_uc003cfs.2_Missense_Mutation_p.R546K|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1348										ovary(3)|central_nervous_system(1)	4						TAGGATTTCTCTTAAAACCTT	0.313			NA											3	10					0	0	0.004672	0	0
CLASP2	23122	broad.mit.edu	37	3	33558651	33558651	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:33558651T>A	uc003cfu.2	-	34	4157	c.3803A>T	c.(3802-3804)CAT>CTT	p.H1268L	CLASP2_uc003cfs.2_Missense_Mutation_p.H475L|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.H868L	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1277										ovary(3)|central_nervous_system(1)	4						TAGGTCAGAATGATCTAGGGA	0.373			NA											12	14					0	0	0.001368	0	0
OXSR1	9943	broad.mit.edu	37	3	38287626	38287626	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:38287626C>T	uc003chy.2	+	13	1513	c.1171C>T	c.(1171-1173)CAT>TAT	p.H391Y	OXSR1_uc010hhb.2_Missense_Mutation_p.H325Y	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	391					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GATCTCTGCTCATCTACCTCA	0.502			NA											12	46					0	0	0.001855	0	0
C3orf39	84892	broad.mit.edu	37	3	43121603	43121603	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:43121603C>A	uc003cmq.1	-	2	1462	c.1321G>T	c.(1321-1323)GAG>TAG	p.E441*	C3orf39_uc003cmr.1_Nonsense_Mutation_p.E441*	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	441						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		AAGAGCCACTCGGGGTTCCGG	0.632			NA											5	15					1.6384e-10	2.62144e-10	0.001984	1	0
ATRIP	84126	broad.mit.edu	37	3	48501642	48501642	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:48501642G>A	uc003ctf.1	+	8	1221	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N	ATRIP_uc011bbj.1_Missense_Mutation_p.D270N|ATRIP_uc003ctg.1_Missense_Mutation_p.D397N|TREX1_uc010hjy.2_5'UTR	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	397					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGCTCACGTGATGGAGACCC	0.547			NA						Other_conserved_DNA_damage_response_genes					26	55					0	0	0.004656	0	0
UBA7	7318	broad.mit.edu	37	3	49845456	49845456	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:49845456G>A	uc003cxr.2	-	20	2691	c.2520C>T	c.(2518-2520)GCC>GCT	p.A840A		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	840					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGGTTACCTGGGCACGGTTGA	0.587			NA											5	9					0	0	0.001168	0	0
SEMA3B	7869	broad.mit.edu	37	3	50308357	50308357	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:50308357T>C	uc003cyu.2	+	6	609	c.367T>C	c.(367-369)TAC>CAC	p.Y123H	SEMA3B_uc010hlh.1_RNA|SEMA3B_uc003cyt.2_Missense_Mutation_p.Y123H|SEMA3B_uc003cyv.2_Missense_Mutation_p.Y10H|SEMA3B_uc003cyw.2_5'UTR|SEMA3B_uc010hli.2_Missense_Mutation_p.Y10H|SEMA3B_uc003cyx.2_Missense_Mutation_p.Y10H|SEMA3B_uc003cyy.2_5'Flank|SEMA3B_uc011bdo.1_5'Flank	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	123	Sema.				axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GCTGCATGCCTACAACCGCAC	0.592			NA											2	6					0	0	0.004672	0	0
IFRD2	7866	broad.mit.edu	37	3	50327638	50327638	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:50327638G>A	uc011bdp.1	-	4	672	c.543C>T	c.(541-543)CTC>CTT	p.L181L	IFRD2_uc003czb.2_Silent_p.L283L	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	181							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CGGCTAGCGTGAGGCGGCGCT	0.642			NA											6	9					0	0	0.001168	0	0
GRM2	2912	broad.mit.edu	37	3	51743227	51743227	+	Silent	SNP	G	G	A	rs140328919		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:51743227G>A	uc010hlv.2	+	2	467	c.228G>A	c.(226-228)CCG>CCA	p.P76P	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	76	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	ACCGTGACCCGCACCTGCTGC	0.632			NA											27	71					0	0	0.007291	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54871258	54871258	+	Splice_Site	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:54871258G>T	uc003dhf.2	+	15	1518	c.1470_splice	c.e15+1	p.T490_splice	CACNA2D3_uc011beu.1_Splice_Site|CACNA2D3_uc003dhg.1_Splice_Site_p.T396_splice|CACNA2D3_uc003dhh.1_Splice_Site|CACNA2D3_uc010hmv.1_Splice_Site_p.T224_splice	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GAACGAAACCGTGAGTACAGT	0.507			NA											19	79					3.62473e-10	5.73653e-10	0.001882	1	0
DNAH12	201625	broad.mit.edu	37	3	57487119	57487120	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:57487119_57487120GG>AA	uc003dit.2	-	11	1444_1445	c.1263_1264CC>TT	c.(1261-1266)CTCCTT>CTTTTT	p.L422F	DNAH12_uc003diu.2_Missense_Mutation_p.L422F	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	422	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						GTCCCATCAAGGAGCCAATTAT	0.282			NA											6	39					0	0	0.004672	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58178443	58178443	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:58178443T>A	uc003djo.1	-	8	986	c.889A>T	c.(889-891)AGG>TGG	p.R297W	DNASE1L3_uc011bfd.1_Missense_Mutation_p.R267W|DNASE1L3_uc003djp.1_Missense_Mutation_p.R297W|DNASE1L3_uc003djq.1_3'UTR	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	297	Nuclear localization signal (Potential).				apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		GTTTTCTTCCTTAGAGTGACA	0.373	Esophageal Squamous(96;1069 1424 4841 43466 52325)		NA											18	63					0	0	0.006122	0	0
EPHA3	2042	broad.mit.edu	37	3	89521734	89521734	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:89521734C>G	uc003dqy.2	+	16	3036	c.2811C>G	c.(2809-2811)TAC>TAG	p.Y937*	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	937	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGTGGAGTACAGTTCTTGTG	0.408			NA								TSP Lung(6;0.00050)			16	50					0	0	0.003163	0	0
ABHD10	55347	broad.mit.edu	37	3	111697944	111697944	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:111697944G>C	uc003dyk.3	+	1	117	c.36G>C	c.(34-36)TGG>TGC	p.W12C	ABHD10_uc011bhq.1_5'UTR	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	12						mitochondrion	serine-type peptidase activity				0						TGGCGGCCTGGGTACCTTGTC	0.687			NA											9	23					0	0	0.006214	0	0
CASR	846	broad.mit.edu	37	3	122003851	122003851	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:122003851A>T	uc003eev.3	+	7	3422	c.3050A>T	c.(3049-3051)CAG>CTG	p.Q1017L	CASR_uc003eew.3_Missense_Mutation_p.Q1027L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	1017	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTCCCGCTGCAGTGCGGGGAA	0.592			NA											9	32					0	0	0.004482	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181690	128181690	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:128181690G>A	uc003ekk.1	-	3	2060	c.399C>T	c.(397-399)GCC>GCT	p.A133A	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	133					protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		CTGCCGAGAAGGCCCCCCTCA	0.597			NA											4	29					0	0	0.000602	0	0
MBD4	8930	broad.mit.edu	37	3	129151986	129151986	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:129151986G>C	uc003emh.1	-	6	1692	c.1516C>G	c.(1516-1518)CTT>GTT	p.L506V	MBD4_uc003emi.1_Missense_Mutation_p.L506V|MBD4_uc003emj.1_Missense_Mutation_p.L500V|MBD4_uc003emk.1_Missense_Mutation_p.L188V|MBD4_uc011bkw.1_Missense_Mutation_p.L506V	NM_003925	NP_003916	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	506					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			ovary(1)|lung(1)	2						TAGAGACCAAGAGGTTTAAGA	0.408			NA						BER_DNA_glycosylases					13	65					0	0	0.001368	0	0
COL6A6	131873	broad.mit.edu	37	3	130305379	130305379	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:130305379G>C	uc010htl.2	+	10	4031	c.4000G>C	c.(4000-4002)GAT>CAT	p.D1334H	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1334	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TGTTGCTCTGGATGGACCTGC	0.423			NA											10	90					0	0	0.001368	0	0
PIK3R4	30849	broad.mit.edu	37	3	130463714	130463714	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:130463714G>A	uc003enj.2	-	2	930	c.349C>T	c.(349-351)CGT>TGT	p.R117C		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	117	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						AAGAATGGACGGGTACTGATG	0.453			NA											20	59					0	0	0.010504	0	0
CPNE4	131034	broad.mit.edu	37	3	131624169	131624169	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:131624169G>C	uc003eok.2	-	2	554	c.119C>G	c.(118-120)GCC>GGC	p.A40G	CPNE4_uc011blq.1_Missense_Mutation_p.A58G|CPNE4_uc003eol.2_Missense_Mutation_p.A58G|CPNE4_uc003eom.2_Missense_Mutation_p.A40G	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	40	C2 1.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTTGGAAAGGGCATCTCTGTC	0.512			NA											8	64					0	0	0.004482	0	0
TF	7018	broad.mit.edu	37	3	133494434	133494434	+	Silent	SNP	C	C	T	rs142894328		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:133494434C>T	uc003epu.1	+	20	3573	c.1845C>T	c.(1843-1845)TGC>TGT	p.C615C	TF_uc011blt.1_Silent_p.C488C|TF_uc003epw.1_Silent_p.C54C|TF_uc003epv.1_Silent_p.C615C	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	615	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	AGGAAGCTTGCGTCCACAAGA	0.532			NA											5	65					0	0	0.001168	0	0
TRIM42	287015	broad.mit.edu	37	3	140401413	140401413	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:140401413C>A	uc003eto.1	+	2	642	c.451C>A	c.(451-453)CGG>AGG	p.R151R		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	151	RING-type.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CATGTGCAGCCGGCTGCGCCT	0.592			NA											50	47					4.10826e-27	7.7282e-27	0.00361	1	0
TRPC1	7220	broad.mit.edu	37	3	142499758	142499758	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:142499758G>T	uc003evc.2	+	6	983	c.847G>T	c.(847-849)GAA>TAA	p.E283*	TRPC1_uc003evb.2_Nonsense_Mutation_p.E249*	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	283	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TCGTGAATTGGAAGTTATTCT	0.373			NA											5	70					1.23904e-05	1.57558e-05	0.000602	1	0
PLSCR4	57088	broad.mit.edu	37	3	145914458	145914458	+	Silent	SNP	T	T	C	rs141714822		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:145914458T>C	uc010huy.2	-	7	1076	c.747A>G	c.(745-747)CCA>CCG	p.P249P	PLSCR4_uc010huz.2_Silent_p.P249P|PLSCR4_uc003evt.3_Silent_p.P249P|PLSCR4_uc010hva.2_Silent_p.P159P|PLSCR4_uc003evu.3_Silent_p.P144P	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	249	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						AGGTTGAGCATGGCCCACGAA	0.418			NA											19	103					0	0	0.00333	0	0
SIAH2	6478	broad.mit.edu	37	3	150460046	150460046	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:150460046C>A	uc003eyi.2	-	2	1484	c.857G>T	c.(856-858)GGT>GTT	p.G286V		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	286	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding	p.G286S(1)		ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CGCAGCCACACCGTCATGAAT	0.527			NA											8	65					1.12685e-05	1.44938e-05	0.004482	1	0
MED12L	116931	broad.mit.edu	37	3	151078261	151078261	+	Splice_Site	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:151078261G>T	uc003eyp.2	+	19	2759	c.2721_splice	c.e19-1	p.G907_splice	MED12L_uc011bnz.1_Splice_Site_p.G767_splice|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Splice_Site_p.G71_splice	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTCTCCTCAGGTTGTGTGGT	0.373			NA											34	190					1.57351e-24	2.94857e-24	0.003755	1	0
CCNL1	57018	broad.mit.edu	37	3	156866174	156866174	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:156866174C>A	uc003fbf.2	-	11	2036	c.1437G>T	c.(1435-1437)CGG>CGT	p.R479R	CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_Silent_p.R273R|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	479					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			CTGAGTGATCCCGAGACTTGC	0.458			NA											20	195					8.00594e-06	1.04263e-05	0.007413	1	0
VEPH1	79674	broad.mit.edu	37	3	157178033	157178033	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:157178033C>A	uc003fbj.1	-	4	783	c.466G>T	c.(466-468)GCA>TCA	p.A156S	VEPH1_uc003fbk.1_Missense_Mutation_p.A156S|VEPH1_uc010hvu.1_Missense_Mutation_p.A156S|VEPH1_uc003fbm.2_Missense_Mutation_p.A156S|VEPH1_uc003fbn.2_Missense_Mutation_p.A156S	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	156						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTGGTAATTGCAGCCAGAGAC	0.483			NA											38	49					3.62531e-18	6.60632e-18	0.004289	1	0
MFSD1	64747	broad.mit.edu	37	3	158537473	158537473	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:158537473T>A	uc003fcl.1	+	8	718	c.688T>A	c.(688-690)TTG>ATG	p.L230M	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.L133M|MFSD1_uc011bow.1_Missense_Mutation_p.L191M|MFSD1_uc011box.1_Missense_Mutation_p.L157M	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	230	Helical; (Potential).				transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AATCTGTGCCTTGGCTCTTGC	0.348	Pancreas(62;1186 1654 36636 37908)		NA											15	23					0	0	0.004007	0	0
MFSD1	64747	broad.mit.edu	37	3	158538032	158538032	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:158538032G>C	uc003fcl.1	+	9	810	c.780G>C	c.(778-780)AAG>AAC	p.K260N	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.K163N|MFSD1_uc011bow.1_Missense_Mutation_p.K221N|MFSD1_uc011box.1_Missense_Mutation_p.K187N	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	260					transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTGATGTAAAGGACTTCTCCT	0.363	Pancreas(62;1186 1654 36636 37908)		NA											7	76					0	0	0.001984	0	0
IL12A	3592	broad.mit.edu	37	3	159706910	159706910	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:159706910G>T	uc003fcx.2	+	1	282	c.67G>T	c.(67-69)GCG>TCG	p.A23S	uc003fcw.1_RNA	NM_000882	NP_000873	P29459	IL12A_HUMAN	interleukin 12A precursor	Error:Variant_position_missing_in_P29459_after_alignment					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TCTGCATCCAGCGGCTCGCCC	0.672			NA									OREG0015908	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12					3.59834e-05	4.49329e-05	0.001168	1	0
SI	6476	broad.mit.edu	37	3	164777083	164777083	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:164777083G>T	uc003fei.2	-	11	1213	c.1151C>A	c.(1150-1152)ACA>AAA	p.T384K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	384	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGTGACCTGTGTATCCTGAAA	0.343			NA								HNSCC(35;0.089)			20	34					5.45024e-15	9.45834e-15	0.00333	1	0
SI	6476	broad.mit.edu	37	3	164777759	164777759	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:164777759G>T	uc003fei.2	-	10	1139	c.1077C>A	c.(1075-1077)CGC>CGA	p.R359R		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	359	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TATAATTCCAGCGACTTAGTT	0.373			NA								HNSCC(35;0.089)			77	120					2.10938e-32	3.98865e-32	0.00361	1	0
BCHE	590	broad.mit.edu	37	3	165548187	165548187	+	Missense_Mutation	SNP	G	G	T	rs114706984	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:165548187G>T	uc003fem.3	-	2	795	c.635C>A	c.(634-636)GCC>GAC	p.A212D	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	212					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TCCACCAAAGGCTGCTATATT	0.438			NA											35	59					1.58521e-26	2.97814e-26	0.005524	1	0
GOLIM4	27333	broad.mit.edu	37	3	167742850	167742850	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:167742850C>A	uc003ffe.2	-	13	2001	c.1657G>T	c.(1657-1659)GAC>TAC	p.D553Y	GOLIM4_uc011bpe.1_Missense_Mutation_p.D554Y|GOLIM4_uc011bpf.1_Missense_Mutation_p.D526Y|GOLIM4_uc011bpg.1_Missense_Mutation_p.D525Y	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	553	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TTATTAGGGTCATCTGCTGGG	0.333			NA											5	84					0.000602214	0.000682885	0.000602	1	0
SLC7A14	57709	broad.mit.edu	37	3	170184886	170184886	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:170184886T>C	uc003fgz.2	-	8	2589	c.2273A>G	c.(2272-2274)GAG>GGG	p.E758G	CLDN11_uc011bpt.1_Intron|uc003fha.1_5'Flank	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	758						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AATCAGGGCCTCTGAGTTCTG	0.433			NA											31	106					0	0	0.004878	0	0
PLD1	5337	broad.mit.edu	37	3	171394595	171394595	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:171394595C>A	uc003fhs.2	-	18	2141	c.2025G>T	c.(2023-2025)CGG>CGT	p.R675R	PLD1_uc003fht.2_Silent_p.R637R|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_5'UTR	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	675	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GCCAGGGCATCCGGGGCGTGG	0.542	NSCLC(149;2174 3517 34058)		NA											19	18					1.22574e-08	1.84558e-08	0.002299	1	0
PLD1	5337	broad.mit.edu	37	3	171404495	171404495	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:171404495C>A	uc003fhs.2	-	16	1963	c.1847G>T	c.(1846-1848)GGA>GTA	p.G616V	PLD1_uc003fht.2_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	616	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TCTAGTGAGTCCTTGCTCAGA	0.423	NSCLC(149;2174 3517 34058)		NA											59	81					5.98616e-33	1.1334e-32	0.00361	1	0
MRPL47	57129	broad.mit.edu	37	3	179316492	179316492	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:179316492G>C	uc003fjz.2	-	4	395	c.373C>G	c.(373-375)CCA>GCA	p.P125A	MRPL47_uc003fka.2_Missense_Mutation_p.P15A|MRPL47_uc003fkb.2_Missense_Mutation_p.P105A	NM_020409	NP_065142	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47 isoform a	125					translation	mitochondrial ribosome	structural constituent of ribosome				0	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			CTTGGCATTGGCAATCTCTGC	0.443			NA											26	58					0	0	0.004656	0	0
PEX5L	51555	broad.mit.edu	37	3	179537683	179537683	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:179537683C>A	uc003fki.1	-	9	1034	c.904G>T	c.(904-906)GCC>TCC	p.A302S	PEX5L_uc011bqd.1_Missense_Mutation_p.A259S|PEX5L_uc011bqe.1_Missense_Mutation_p.A110S|PEX5L_uc011bqf.1_Missense_Mutation_p.A194S|PEX5L_uc003fkj.1_Missense_Mutation_p.A267S|PEX5L_uc010hxd.1_Missense_Mutation_p.A300S|PEX5L_uc011bqg.1_Missense_Mutation_p.A278S|PEX5L_uc011bqh.1_Missense_Mutation_p.A243S	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	302					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TGGTTCTGGGCTTCTTGGTTC	0.423			NA											7	71					1.06961e-07	1.54041e-07	0.00308	1	0
ABCC5	10057	broad.mit.edu	37	3	183643372	183643372	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:183643372C>A	uc003fmg.2	-	29	4348	c.4183G>T	c.(4183-4185)GAT>TAT	p.D1395Y	ABCC5_uc011bqt.1_Missense_Mutation_p.D923Y|ABCC5_uc010hxl.2_Missense_Mutation_p.D1352Y	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1395	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATAATCCTATCGGAGCCTAGA	0.542			NA											7	48					8.12818e-05	9.82943e-05	0.001984	1	0
HTR3C	170572	broad.mit.edu	37	3	183774708	183774708	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:183774708C>A	uc003fmk.2	+	5	469	c.435C>A	c.(433-435)AGC>AGA	p.S145R		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	145	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCTATATCAGCAGTGAAGGTC	0.483			NA											9	106					1.76689e-08	2.62778e-08	0.006214	1	0
IL1RAP	3556	broad.mit.edu	37	3	190363614	190363614	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:190363614A>G	uc003fsm.1	+	11	1534	c.1328A>G	c.(1327-1329)GAC>GGC	p.D443G	IL1RAP_uc010hzg.1_Missense_Mutation_p.D443G|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.D443G|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Missense_Mutation_p.D443G	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	443	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TTTGACCGAGACAGTCTGCCT	0.433			NA											3	42					0	0	0.004672	0	0
OSTN	344901	broad.mit.edu	37	3	190930383	190930383	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:190930383G>T	uc011bsn.1	+	1	62	c.62G>T	c.(61-63)AGC>ATC	p.S21I		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	21					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		ACACTGTGGAGCTCAGGAAAA	0.388			NA											11	11					9.31168e-06	1.20836e-05	0.001855	1	0
TFRC	7037	broad.mit.edu	37	3	195792371	195792371	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr3:195792371G>T	uc003fvz.3	-	10	1424	c.1141C>A	c.(1141-1143)CTG>ATG	p.L381M	TFRC_uc003fwa.3_Missense_Mutation_p.L381M|TFRC_uc010hzy.2_Missense_Mutation_p.L300M|TFRC_uc011btr.1_Missense_Mutation_p.L99M	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	381	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		ATCTCTTTCAGCACATTGCTC	0.328			NA	T	BCL6	NHL								5	95					3.59834e-05	4.49329e-05	0.001168	1	0
PIGG	54872	broad.mit.edu	37	4	533009	533009	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:533009A>G	uc003gak.3	+	13	2939	c.2803A>G	c.(2803-2805)ATC>GTC	p.I935V	PIGG_uc003gaj.3_Missense_Mutation_p.I927V|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.I802V|PIGG_uc003gal.3_Missense_Mutation_p.I846V	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	935	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TTTCACGTACATCGTTTTGGT	0.393			NA											12	67					0	0	0.001368	0	0
GAK	2580	broad.mit.edu	37	4	844769	844769	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:844769C>A	uc003gbm.3	-	26	3811	c.3612G>T	c.(3610-3612)ATG>ATT	p.M1204I	GAK_uc003gbn.3_Missense_Mutation_p.M1125I|GAK_uc003gbk.3_Missense_Mutation_p.M1I|GAK_uc010ibi.2_Missense_Mutation_p.M429I|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.M1057I	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1204					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CCTGCTTCCTCATCTCTGCAA	0.542			NA											24	73					1.85244e-09	2.87237e-09	0.00333	1	0
NOP14	8602	broad.mit.edu	37	4	2951843	2951843	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:2951843C>A	uc003ggj.1	-	8	1172	c.1100G>T	c.(1099-1101)GGG>GTG	p.G367V	C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.G113V|NOP14_uc003ggk.3_Missense_Mutation_p.G367V|NOP14_uc003ggl.2_Missense_Mutation_p.G367V	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	367					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TGTGTCCTCCCCGCCTGAACT	0.532			NA											29	134					1.80694e-10	2.88794e-10	0.009535	1	0
OTOP1	133060	broad.mit.edu	37	4	4199402	4199402	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:4199402G>T	uc003ghp.1	-	5	1189	c.1159C>A	c.(1159-1161)CGC>AGC	p.R387S		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	387					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCCAGTTTGCGGGCCGGATTT	0.602			NA											14	48					5.01169e-05	6.18917e-05	0.00499	1	0
C4orf50	389197	broad.mit.edu	37	4	5975560	5975560	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:5975560T>A	uc003git.1	-	4	324	c.234A>T	c.(232-234)ATA>ATT	p.I78I		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	78										pancreas(2)|breast(1)	3						CGAGGGAAGCTATCTTGGCCT	0.667			NA											4	21					0	0	0.009096	0	0
KIAA0232	9778	broad.mit.edu	37	4	6863811	6863811	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:6863811A>G	uc003gjr.3	+	7	2165	c.1702A>G	c.(1702-1704)ACA>GCA	p.T568A	KIAA0232_uc003gjq.3_Missense_Mutation_p.T568A	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	568							ATP binding			ovary(2)	2						TGCAATATGGACAGATTCTAC	0.478			NA											20	90					0	0	0.008871	0	0
SLC2A9	56606	broad.mit.edu	37	4	9836505	9836505	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:9836505C>A	uc003gmc.2	-	11	1480	c.1419G>T	c.(1417-1419)CAG>CAT	p.Q473H	SLC2A9_uc003gmd.2_Missense_Mutation_p.Q444H	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	473	Extracellular (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						TCAGTCATACCTGAATGAATG	0.512			NA											3	17					0.004672	0.00503511	0.004672	1	0
BOD1L	259282	broad.mit.edu	37	4	13604728	13604728	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:13604728C>A	uc003gmz.1	-	10	3913	c.3796G>T	c.(3796-3798)GCT>TCT	p.A1266S	BOD1L_uc010idr.1_Missense_Mutation_p.A603S	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1266							DNA binding			ovary(5)|breast(1)	6						TCTCCTTGAGCAACATGTTCT	0.408			NA											9	30					7.48243e-07	1.03265e-06	0.006214	1	0
SLIT2	9353	broad.mit.edu	37	4	20543244	20543244	+	Splice_Site	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:20543244T>C	uc003gpr.1	+	20	2347	c.2143_splice	c.e20+2	p.G715_splice	SLIT2_uc003gps.1_Splice_Site_p.G707_splice	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GTGATGACGGTAAGAAATACT	0.408			NA											10	49					0	0	0.000978	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23816059	23816059	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:23816059C>A	uc003gqs.2	-	8	1167	c.1047G>T	c.(1045-1047)CCG>CCT	p.P349P	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	349					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CGGATTGCTCCGGCCCTTTCT	0.537	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											21	83					1.10923e-09	1.73474e-09	0.00278	1	0
PPARGC1A	10891	broad.mit.edu	37	4	23833288	23833288	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:23833288G>A	uc003gqs.2	-	3	441	c.321C>T	c.(319-321)CCC>CCT	p.P107P	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	107					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CATCAAATGAGGGCAATCCGT	0.527	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											33	186					0	0	0.004878	0	0
GABRA2	2555	broad.mit.edu	37	4	46305517	46305517	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:46305517G>T	uc003gxc.3	-	7	1489	c.816C>A	c.(814-816)TTC>TTA	p.F272L	GABRA2_uc010igc.2_Missense_Mutation_p.F272L|GABRA2_uc011bzc.1_Missense_Mutation_p.F217L|GABRA2_uc003gxe.2_Missense_Mutation_p.F272L	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	272	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTTAAGCCAGAATGAAACTT	0.299			NA											12	66					1.5842e-08	2.37548e-08	0.001855	1	0
GABRA4	2557	broad.mit.edu	37	4	46930427	46930427	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:46930427C>A	uc003gxg.2	-	9	1619	c.1480G>T	c.(1480-1482)GGG>TGG	p.G494W		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	494	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCAGTAGCCCCTATGGTATTA	0.468	Ovarian(6;283 369 8234 12290 33402)		NA											13	51					0.000151284	0.000181292	0.001855	1	0
KDR	3791	broad.mit.edu	37	4	55971037	55971037	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:55971037C>A	uc003has.2	-	13	2062	c.1760G>T	c.(1759-1761)GGC>GTC	p.G587V	KDR_uc003hat.1_Missense_Mutation_p.G587V|KDR_uc011bzx.1_Missense_Mutation_p.G587V	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	587	Ig-like C2-type 6.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGGCTGTGGGCCAAGCTTGTA	0.498			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			7	41					5.18039e-06	6.82593e-06	0.00308	1	0
LPHN3	23284	broad.mit.edu	37	4	62845314	62845314	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:62845314G>T	uc010ihh.2	+	15	2808	c.2635G>T	c.(2635-2637)GTG>TTG	p.V879L	LPHN3_uc003hcq.3_Missense_Mutation_p.V879L|LPHN3_uc003hct.2_Missense_Mutation_p.V272L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	866	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCTTCTGGATGTGATCACGTG	0.448			NA											38	144					1.20271e-06	1.64736e-06	0.00874	1	0
LPHN3	23284	broad.mit.edu	37	4	62849169	62849169	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:62849169G>T	uc010ihh.2	+	16	3053	c.2880G>T	c.(2878-2880)CTG>CTT	p.L960L	LPHN3_uc003hcq.3_Silent_p.L960L|LPHN3_uc003hct.2_Silent_p.L353L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	947	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GGATGTTCCTGGAGGGGGTGC	0.453			NA											9	40					0.000442599	0.000512261	0.006214	1	0
TECRL	253017	broad.mit.edu	37	4	65155456	65155456	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:65155456A>T	uc003hcv.2	-	9	913	c.804T>A	c.(802-804)AAT>AAA	p.N268K		NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	268					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ACAACATTACATTGATGAAAT	0.284			NA											4	18					0	0	0.000602	0	0
EPHA5	2044	broad.mit.edu	37	4	66270133	66270133	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:66270133G>T	uc003hcy.2	-	8	1942	c.1749C>A	c.(1747-1749)GTC>GTA	p.V583V	EPHA5_uc003hcx.2_Silent_p.V515V|EPHA5_uc003hcz.2_Silent_p.V583V|EPHA5_uc011cah.1_Silent_p.V584V|EPHA5_uc011cai.1_Silent_p.V584V|EPHA5_uc003hda.2_Silent_p.V584V	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	583	Helical; (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCAACAAAATGACTCCCACTG	0.473			NA								TSP Lung(17;0.13)			10	45					0.000673444	0.000757755	0.008291	1	0
TMPRSS11F	389208	broad.mit.edu	37	4	68934442	68934442	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:68934442C>G	uc003hdt.1	-	7	698	c.649G>C	c.(649-651)GAA>CAA	p.E217Q	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	217	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						CATGGCCATTCCCCTTCCATA	0.522			NA											17	60					0	0	0.006122	0	0
UGT2B11	10720	broad.mit.edu	37	4	70071210	70071210	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:70071210T>G	uc003heh.2	-	4	1087	c.1078A>C	c.(1078-1080)AAT>CAT	p.N360H	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	360					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						AGAAGGTCATTCTGGGGTATC	0.378			NA											7	69					0	0	0.001984	0	0
UGT2B11	10720	broad.mit.edu	37	4	70071213	70071213	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:70071213G>T	uc003heh.2	-	4	1084	c.1075C>A	c.(1075-1077)CAG>AAG	p.Q359K	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	359					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						AGGTCATTCTGGGGTATCCAC	0.373			NA											8	69					0.00307968	0.0033563	0.00308	1	0
CSN2	1447	broad.mit.edu	37	4	70823494	70823494	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:70823494G>A	uc003hes.3	-	5	186	c.173C>T	c.(172-174)TCT>TTT	p.S58F	CSN2_uc003het.3_Missense_Mutation_p.S57F	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	58					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						TGGCTGGAAAGAGGGGTAGAT	0.418			NA											12	43					0	0	0.001855	0	0
MUC7	4589	broad.mit.edu	37	4	71346651	71346651	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:71346651A>G	uc011cat.1	+	4	478	c.190A>G	c.(190-192)AAA>GAA	p.K64E	MUC7_uc011cau.1_Missense_Mutation_p.K64E|MUC7_uc003hfj.2_Missense_Mutation_p.K64E|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	64						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			AAAGTCCTATAAATGTCTGCA	0.443			NA											17	88					0	0	0.00499	0	0
MUC7	4589	broad.mit.edu	37	4	71346954	71346954	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:71346954A>G	uc011cat.1	+	4	781	c.493A>G	c.(493-495)ACC>GCC	p.T165A	MUC7_uc011cau.1_Missense_Mutation_p.T165A|MUC7_uc003hfj.2_Missense_Mutation_p.T165A|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	165	1.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			TCCACAAGACACCACAGCTGC	0.527			NA											19	61					0	0	0.008871	0	0
SHROOM3	57619	broad.mit.edu	37	4	77675466	77675466	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:77675466C>T	uc011cbx.1	+	7	4783	c.3830C>T	c.(3829-3831)TCA>TTA	p.S1277L	SHROOM3_uc003hkg.2_Missense_Mutation_p.S1055L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1277					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CGTTCCAGGTCACTCAGTTGT	0.512			NA											4	165					0	0	0.009096	0	0
ANKRD56	345079	broad.mit.edu	37	4	77817745	77817745	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:77817745C>T	uc003hki.2	-	1	1258	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	420											0						AGCCCCTCTTCAGAAGCCCCC	0.602			NA											13	75					0	0	0.003163	0	0
PAQR3	152559	broad.mit.edu	37	4	79847698	79847698	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:79847698C>G	uc003hlp.1	-	4	883	c.679G>C	c.(679-681)GGA>CGA	p.G227R	PAQR3_uc003hlm.2_RNA|PAQR3_uc003hln.2_RNA|PAQR3_uc003hlq.1_Missense_Mutation_p.G109R	NM_001040202	NP_001035292	Q6TCH7	PAQR3_HUMAN	progestin and adipoQ receptor family member III	227	Lumenal (Potential).					Golgi membrane|integral to membrane	receptor activity				0						GCACCAATTCCTCCATTGAGC	0.378			NA											10	54					0	0	0.000978	0	0
GK2	2712	broad.mit.edu	37	4	80327728	80327728	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:80327728G>T	uc003hlu.2	-	1	1645	c.1627C>A	c.(1627-1629)CTA>ATA	p.L543I		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	543					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						GCTCCAATTAGCATTACCATG	0.408			NA											6	43					8.12818e-05	9.82943e-05	0.001984	1	0
RASGEF1B	153020	broad.mit.edu	37	4	82366732	82366732	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:82366732T>A	uc003hmi.1	-	8	1020	c.876A>T	c.(874-876)GTA>GTT	p.V292V	RASGEF1B_uc003hmj.1_Silent_p.V291V|RASGEF1B_uc010ijq.1_Silent_p.V250V	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	292	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						ACTCCCGAGCTACGTCAATGA	0.403			NA											21	71					0	0	0.001882	0	0
PTPN13	5783	broad.mit.edu	37	4	87693953	87693953	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:87693953G>T	uc003hpz.2	+	32	5671	c.5191G>T	c.(5191-5193)GAT>TAT	p.D1731Y	PTPN13_uc003hpy.2_Missense_Mutation_p.D1736Y|PTPN13_uc003hqa.2_Missense_Mutation_p.D1712Y|PTPN13_uc003hqb.2_Missense_Mutation_p.D1540Y|PTPN13_uc003hqc.1_Missense_Mutation_p.D97Y	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1731						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCTACCACCGGATATGGCTCC	0.383			NA											16	60					1.99824e-07	2.83847e-07	0.00499	1	0
SLC10A6	345274	broad.mit.edu	37	4	87770178	87770178	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:87770178C>A	uc003hqd.2	-	1	239	c.91G>T	c.(91-93)GAG>TAG	p.E31*		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	31	Helical; (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		AAAACGAGCTCCAGGTTTCCA	0.557			NA											9	38					1.12685e-05	1.44938e-05	0.004482	1	0
DMP1	1758	broad.mit.edu	37	4	88583789	88583789	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:88583789A>T	uc003hqv.2	+	6	963	c.859A>T	c.(859-861)ACA>TCA	p.T287S	DMP1_uc003hqw.2_Missense_Mutation_p.T271S	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	287					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TGACAACAACACAATGGAAGA	0.483			NA											3	19					0	0	0.004672	0	0
ABCG2	9429	broad.mit.edu	37	4	89052318	89052318	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:89052318G>A	uc003hrg.2	-	5	919	c.426C>T	c.(424-426)TTC>TTT	p.F142F	ABCG2_uc003hrh.2_Silent_p.F142F|ABCG2_uc003hrf.2_Silent_p.F12F	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	142	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAGCTGCTGAGAACTGTAAGT	0.398			NA											29	83					0	0	0.007291	0	0
C4orf21	55345	broad.mit.edu	37	4	113539234	113539234	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:113539234T>A	uc003iau.2	-	6	2175	c.1964A>T	c.(1963-1965)TAC>TTC	p.Y655F	C4orf21_uc003iaw.2_Missense_Mutation_p.Y655F	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATTATCTCCGTATACAGCATC	0.318			NA											13	47					0	0	0.00245	0	0
FAT4	79633	broad.mit.edu	37	4	126412051	126412051	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:126412051T>A	uc003ifj.3	+	17	14074	c.14074T>A	c.(14074-14076)TGC>AGC	p.C4692S	FAT4_uc011cgp.1_Missense_Mutation_p.C2933S|FAT4_uc003ifi.1_Missense_Mutation_p.C2169S	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4692	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCACTCAGCATGCCCAACTCC	0.502			NA											15	52					0	0	0.00499	0	0
PCDH10	57575	broad.mit.edu	37	4	134072090	134072090	+	Silent	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:134072090A>C	uc003iha.2	+	1	1621	c.795A>C	c.(793-795)CCA>CCC	p.P265P	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.P265P	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	265	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		ACTCTCCCCCAGGCACTCTCG	0.627			NA											9	45					0	0	0.004482	0	0
SMAD1	4086	broad.mit.edu	37	4	146463845	146463845	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:146463845G>A	uc003ikc.2	+	4	1186	c.770G>A	c.(769-771)AGA>AAA	p.R257K	SMAD1_uc003ikd.2_Missense_Mutation_p.R257K|SMAD1_uc010iov.2_Missense_Mutation_p.R257K|SMAD1_uc011cic.1_Intron	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1	257					BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					GAAATCAACAGAGGAGGTAAA	0.453	Pancreas(182;1287 2092 10326 35158 50562)		NA											4	26					0	0	0.000602	0	0
TTC29	83894	broad.mit.edu	37	4	147824814	147824814	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:147824814C>A	uc003ikw.3	-	6	695	c.468G>T	c.(466-468)AAG>AAT	p.K156N	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.K182N|TTC29_uc010ipd.1_Missense_Mutation_p.K156N	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	156							binding				0	all_hematologic(180;0.151)					TCCTTACCCACTTGTCTTCAG	0.403			NA											3	14					2.56e-06	3.4196e-06	0.009096	1	0
MAB21L2	10586	broad.mit.edu	37	4	151504190	151504190	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:151504190C>A	uc003ilw.2	+	1	1114	c.9C>A	c.(7-9)GCC>GCA	p.A3A	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	3					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		ACATGATCGCCGCTCAGGCCA	0.597			NA											8	16					5.18039e-06	6.82593e-06	0.00308	1	0
LRBA	987	broad.mit.edu	37	4	151849739	151849739	+	Missense_Mutation	SNP	C	C	G	rs61746090		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:151849739C>G	uc010ipj.2	-	4	952	c.478G>C	c.(478-480)GCT>CCT	p.A160P	LRBA_uc003ilu.3_Missense_Mutation_p.A160P|LRBA_uc010ipk.1_Missense_Mutation_p.A79P	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	160						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTATAGCTAGCCAGCACTCCC	0.338			NA											5	24					0	0	0.000602	0	0
DCHS2	54798	broad.mit.edu	37	4	155156835	155156835	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:155156835A>C	uc003inw.2	-	25	7604	c.7604T>G	c.(7603-7605)TTC>TGC	p.F2535C		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2535					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GCTGCTGGCGAACACTGCCAA	0.388			NA											9	34					0	0	0.004482	0	0
DCHS2	54798	broad.mit.edu	37	4	155256183	155256183	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:155256183G>T	uc003inw.2	-	8	1053	c.1053C>A	c.(1051-1053)GAC>GAA	p.D351E	DCHS2_uc003inx.2_Missense_Mutation_p.D850E	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	351	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GCCCACCACCGTCTTGAGCAG	0.428			NA											7	41					0.00829132	0.00888966	0.008291	1	0
ETFDH	2110	broad.mit.edu	37	4	159601639	159601639	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:159601639T>C	uc003iqb.2	+	2	387	c.55T>C	c.(55-57)TTA>CTA	p.L19L	ETFDH_uc011cjg.1_Intron|ETFDH_uc010iqr.2_Intron|ETFDH_uc011cjh.1_5'Flank|ETFDH_uc010iqs.2_5'Flank	NM_004453	NP_004444	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	19					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		CTTTCATGCCTTAAAAATTAA	0.323			NA											11	46					0	0	0.000978	0	0
FNIP2	57600	broad.mit.edu	37	4	159780333	159780333	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:159780333A>T	uc003iqe.3	+	9	1165	c.982A>T	c.(982-984)AAT>TAT	p.N328Y		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	328					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		AGCACAAAGGAATTTCCAGGA	0.393			NA											4	27					0	0	0.000602	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160264503	160264503	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:160264503C>T	uc003iqg.3	+	16	3028	c.2718C>T	c.(2716-2718)CAC>CAT	p.H906H		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	906	Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		AAATTCGTCACGTTGGCCGAA	0.453			NA											13	52					0	0	0.001855	0	0
NPY1R	4886	broad.mit.edu	37	4	164246890	164246890	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:164246890C>A	uc003iqm.1	-	3	986	c.720G>T	c.(718-720)AGG>AGT	p.R240S	NPY1R_uc011cjj.1_5'UTR	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	240	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGTTGTTTCTCCTTTTTAGGC	0.343			NA											6	21					0.000274275	0.000319476	0.004482	1	0
NPY5R	4889	broad.mit.edu	37	4	164272461	164272461	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:164272461G>A	uc003iqn.2	+	4	1218	c.1036G>A	c.(1036-1038)GAT>AAT	p.D346N		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	346	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				AGAAAATTCAGATGTTCATGA	0.373	Melanoma(139;1287 1774 9781 19750 25599)		NA											11	41					0	0	0.000978	0	0
HPGD	3248	broad.mit.edu	37	4	175416704	175416704	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:175416704C>A	uc003itu.2	-	5	683	c.493G>T	c.(493-495)GCA>TCA	p.A165S	HPGD_uc003itt.2_Missense_Mutation_p.A32S|HPGD_uc003itv.2_Missense_Mutation_p.A165S|HPGD_uc011ckf.1_Missense_Mutation_p.A44S|HPGD_uc010irp.2_Missense_Mutation_p.A44S|HPGD_uc010irq.2_Intron|HPGD_uc011ckg.1_Missense_Mutation_p.A97S|HPGD_uc011ckh.1_Missense_Mutation_p.A44S|HPGD_uc003itw.2_Missense_Mutation_p.A165S	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	165					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	CTCACCGCTGCTGAGCGTGTG	0.408			NA											9	39					0.00448238	0.00486678	0.004482	1	0
VEGFC	7424	broad.mit.edu	37	4	177648957	177648957	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:177648957G>T	uc003ius.1	-	3	957	c.527C>A	c.(526-528)ACC>AAC	p.T176N		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	176					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GCTCGTGCTGGTGTTCATGCA	0.512			NA											8	20					0.000274275	0.000319476	0.004482	1	0
F11	2160	broad.mit.edu	37	4	187192858	187192858	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:187192858A>C	uc003iza.1	+	3	484	c.151A>C	c.(151-153)ACT>CCT	p.T51P	F11_uc003iyz.2_Missense_Mutation_p.T51P	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	51	Apple 1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GGTAGTCTGCACTTACCACCC	0.488			NA											11	59					0	0	0.000978	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455454	187455454	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:187455454C>T	uc003izd.1	-	2	460	c.442G>A	c.(442-444)GTG>ATG	p.V148M		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	148	Helical; Name=4; (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	ATGAGGAGCACGTAGCAGAGG	0.572			NA											9	37					0	0	0.008291	0	0
FAT1	2195	broad.mit.edu	37	4	187542468	187542468	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:187542468C>G	uc003izf.2	-	10	5460	c.5272G>C	c.(5272-5274)GAG>CAG	p.E1758Q		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1758	Extracellular (Potential).|Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTGTCATTCTCATCCTGCAAG	0.428	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			8	52					0	0	0.004482	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	155007	155007	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:155007C>G	uc003jak.2	+	6	992	c.942C>G	c.(940-942)TCC>TCG	p.S314S		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	314					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TCGTGAGCTCCCTGAAGGCCG	0.562			NA											9	24					0	0	0.004482	0	0
EXOC3	11336	broad.mit.edu	37	5	453846	453846	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:453846G>A	uc003jba.2	+	4	854	c.726G>A	c.(724-726)AAG>AAA	p.K242K		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	253					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GGAGGCCCAAGAATTGGAAGG	0.483			NA											4	54					0	0	0.009096	0	0
TRIP13	9319	broad.mit.edu	37	5	895012	895012	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:895012G>A	uc003jbr.2	+	2	313	c.203G>A	c.(202-204)AGA>AAA	p.R68K	BRD9_uc003jbn.2_5'Flank|BRD9_uc011cmb.1_5'Flank|BRD9_uc003jbo.2_5'Flank|BRD9_uc003jbq.2_5'Flank|BRD9_uc011cmc.1_5'Flank|TRIP13_uc010ite.1_Missense_Mutation_p.R68K	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	68					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			TTTTTGACCAGAAATGTGCAG	0.363			NA											11	58					0	0	0.000978	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630090	9630090	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:9630090G>T	uc003jem.1	-	1	374	c.55C>A	c.(55-57)CTT>ATT	p.L19I		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	19	Helical; Name=1; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						AAAATCCCAAGAAGAAATTGT	0.338			NA											5	53					0.000602214	0.000682885	0.000602	1	0
CTNND2	1501	broad.mit.edu	37	5	11098738	11098738	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:11098738C>A	uc003jfa.1	-	15	2731	c.2586G>T	c.(2584-2586)ACG>ACT	p.T862T	CTNND2_uc010itt.2_Silent_p.T771T|CTNND2_uc011cmy.1_Silent_p.T525T|CTNND2_uc011cmz.1_Silent_p.T429T|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.T429T	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	862	ARM 7.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CCCCTTCCAGCGTGTCTGGAT	0.517			NA											11	42					0.000151284	0.000181292	0.001855	1	0
DNAH5	1767	broad.mit.edu	37	5	13776646	13776646	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:13776646C>G	uc003jfd.2	-	55	9317	c.9275G>C	c.(9274-9276)GGG>GCG	p.G3092A		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3092	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAATTTCTCCCCCACTGGCGA	0.498			NA							Kartagener_syndrome				25	63					0	0	0.00333	0	0
MARCH11	441061	broad.mit.edu	37	5	16091001	16091001	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:16091001T>G	uc003jfo.2	-	3	1096	c.883A>C	c.(883-885)ATA>CTA	p.I295L	MARCH11_uc010itw.1_Missense_Mutation_p.I51L	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	295	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						GTCTTACCTATGCACACTAGA	0.438			NA											9	20					0	0	0.006214	0	0
FAM134B	54463	broad.mit.edu	37	5	16565879	16565879	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:16565879T>A	uc003jfs.2	-	3	489	c.451A>T	c.(451-453)AGT>TGT	p.S151C		NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	151					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						TACCTTTCACTGAGGCTTCTC	0.438			NA											4	18					0	0	0.000602	0	0
BASP1	10409	broad.mit.edu	37	5	17275961	17275961	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:17275961G>T	uc003jfx.2	+	2	815	c.636G>T	c.(634-636)GTG>GTT	p.V212V		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	212					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						CCAAGCCGGTGGAGGCCCCGG	0.552			NA											5	26					8.12818e-05	9.82943e-05	0.001984	1	0
MTMR12	54545	broad.mit.edu	37	5	32248925	32248925	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:32248925T>A	uc003jhq.2	-	9	1019	c.849A>T	c.(847-849)AAA>AAT	p.K283N	MTMR12_uc010iuk.2_Missense_Mutation_p.K283N|MTMR12_uc010iul.2_Missense_Mutation_p.K283N	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	283	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						CATCCTGTTCTTTGGGCAGTG	0.388			NA											32	94					0	0	0.004878	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33643550	33643550	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:33643550G>T	uc003jia.1	-	10	1668	c.1505C>A	c.(1504-1506)TCC>TAC	p.S502Y	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S502Y	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	502	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCCCTTCACGGAGCACCACAG	0.463			NA								HNSCC(64;0.19)			12	44					1.08611e-07	1.558e-07	0.000978	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33649028	33649028	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:33649028C>A	uc003jia.1	-	9	1541	c.1378G>T	c.(1378-1380)GGC>TGC	p.G460C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G460C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	460					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GACTTCAAGCCTTTCTTTTTA	0.468			NA								HNSCC(64;0.19)			17	54					9.95505e-16	1.75905e-15	0.002299	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33649046	33649046	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:33649046C>T	uc003jia.1	-	9	1523	c.1360G>A	c.(1360-1362)GAC>AAC	p.D454N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.D454N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	454	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTAGGTATGTCATCAAGACAG	0.453			NA								HNSCC(64;0.19)			14	45					0	0	0.003163	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33751520	33751520	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:33751520C>T	uc003jia.1	-	3	786	c.623G>A	c.(622-624)TGT>TAT	p.C208Y	ADAMTS12_uc010iuq.1_Missense_Mutation_p.C208Y|ADAMTS12_uc003jib.1_Missense_Mutation_p.C208Y	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	208	Cysteine switch (By similarity).	Zinc; in inhibited form (By similarity).			proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTTTAATCCACAGGTTGGCTC	0.438			NA								HNSCC(64;0.19)			16	53					0	0	0.00499	0	0
SPEF2	79925	broad.mit.edu	37	5	35691205	35691205	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:35691205A>G	uc003jjo.2	+	11	1702	c.1591A>G	c.(1591-1593)ATA>GTA	p.I531V	SPEF2_uc003jjq.3_Missense_Mutation_p.I531V|SPEF2_uc003jjp.1_Missense_Mutation_p.I22V	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	531					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAACAATTGCATACTGGGCCA	0.398			NA											14	75					0	0	0.00245	0	0
IL7R	3575	broad.mit.edu	37	5	35873708	35873708	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:35873708C>A	uc003jjs.2	+	5	753	c.664C>A	c.(664-666)CCA>ACA	p.P222T	IL7R_uc011coo.1_Missense_Mutation_p.P222T|IL7R_uc011cop.1_Intron	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	222	Extracellular (Potential).|Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGAATGGAGTCCAAGTTATTA	0.433			NA											22	55					6.44725e-10	1.01374e-09	0.002299	1	0
FYB	2533	broad.mit.edu	37	5	39119135	39119135	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:39119135C>A	uc003jls.2	-	14	2171	c.2104G>T	c.(2104-2106)GAT>TAT	p.D702Y	FYB_uc003jlt.2_Missense_Mutation_p.D748Y|FYB_uc003jlu.2_Missense_Mutation_p.D702Y|FYB_uc011cpl.1_Missense_Mutation_p.D758Y	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	702					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			ATTTCACCATCATACTAAAAA	0.279			NA											3	12					0.00909568	0.00969496	0.009096	1	0
C9	735	broad.mit.edu	37	5	39306837	39306837	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:39306837G>C	uc003jlv.3	-	9	1387	c.1298C>G	c.(1297-1299)ACC>AGC	p.T433S		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	433	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ATATTTTCTGGTTCCACCTCT	0.398			NA											4	60					0	0	0.000602	0	0
DAB2	1601	broad.mit.edu	37	5	39393458	39393458	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:39393458G>A	uc003jlx.2	-	3	660	c.129C>T	c.(127-129)TTC>TTT	p.F43F	DAB2_uc003jlw.2_Silent_p.F43F	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	43					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CATCGCCTTTGAACCTTGCTA	0.388			NA											11	126					0	0	0.008291	0	0
RPL37	6167	broad.mit.edu	37	5	40834695	40834695	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:40834695G>A	uc003jme.1	-	2	117	c.17C>T	c.(16-18)TCA>TTA	p.S6L	SNORD72_uc003jmf.1_5'Flank	NM_000997	NP_000988	P61927	RL37_HUMAN	ribosomal protein L37	6					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	metal ion binding|protein binding|rRNA binding|structural constituent of ribosome				0		Breast(839;0.238)				TCCAAACGATGACGTTCCCTT	0.468	Colon(188;1411 2035 4978 19588 31462)		NA											15	47					0	0	0.00499	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41032890	41032890	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:41032890C>A	uc003jmj.3	-	24	2885	c.2395G>T	c.(2395-2397)GCT>TCT	p.A799S	HEATR7B2_uc003jmi.3_Missense_Mutation_p.A354S	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	799	HEAT 9.						binding			ovary(6)|central_nervous_system(2)	8						ATAGGGCTAGCTAAGGAATCC	0.398			NA											4	10					0.00024832	0.000292993	0.009096	1	0
C5orf39	389289	broad.mit.edu	37	5	43040126	43040126	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:43040126C>A	uc003jnf.2	-	1	322	c.23G>T	c.(22-24)TGT>TTT	p.C8F	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	8							receptor activity				0						CCGCTTCACACAGCCAAGAAA	0.547			NA									OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	55					0.000602214	0.000682885	0.000602	1	0
MRPS30	10884	broad.mit.edu	37	5	44809482	44809482	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:44809482G>T	uc003joh.2	+	1	456	c.418G>T	c.(418-420)GCG>TCG	p.A140S	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	140					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					GCTGGACCTCGCGGCGCTGCG	0.567			NA											8	11					0.00307968	0.0033563	0.00308	1	0
ISL1	3670	broad.mit.edu	37	5	50680542	50680542	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:50680542T>A	uc003jor.2	+	2	744	c.196T>A	c.(196-198)TAC>AAC	p.Y66N	uc003joq.1_5'Flank	NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	66	LIM zinc-binding 1.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				TGGGAAAACCTACTGTAAAAG	0.403			NA											11	142					0	0	0.008291	0	0
PDE4D	5144	broad.mit.edu	37	5	59284456	59284456	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:59284456C>G	uc003jsb.2	-	3	344	c.131G>C	c.(130-132)CGC>CCC	p.R44P	PDE4D_uc010iwj.1_Missense_Mutation_p.R44P|PDE4D_uc003jse.1_Missense_Mutation_p.R56P	NM_006203	NP_006194	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 2	Error:Variant_position_missing_in_Q08499_after_alignment					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CTGAATATTGCGACATGAAAG	0.483			NA											27	42					0	0	0.002096	0	0
RNF180	285671	broad.mit.edu	37	5	63509680	63509680	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:63509680G>A	uc003jti.2	+	4	637	c.527G>A	c.(526-528)GGA>GAA	p.G176E	RNF180_uc003jth.3_Missense_Mutation_p.G176E|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	176	Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		AATGACCCTGGAAGATTAACA	0.443			NA											21	36					0	0	0.001882	0	0
TNPO1	3842	broad.mit.edu	37	5	72171445	72171445	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:72171445C>G	uc003kck.3	+	8	829	c.682C>G	c.(682-684)CTC>GTC	p.L228V	TNPO1_uc011csi.1_RNA|TNPO1_uc011csj.1_Missense_Mutation_p.L178V|TNPO1_uc003kch.2_Missense_Mutation_p.L220V|TNPO1_uc003kci.3_Missense_Mutation_p.L220V|TNPO1_uc003kcg.3_Missense_Mutation_p.L220V	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	228	HEAT 3.				interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		GCAACAGAATCTCTTTGCATT	0.393			NA											6	44					0	0	0.001168	0	0
PDE8B	8622	broad.mit.edu	37	5	76627258	76627258	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:76627258C>A	uc003kfa.2	+	5	727	c.682C>A	c.(682-684)CCT>ACT	p.P228T	PDE8B_uc003kfb.2_Missense_Mutation_p.P208T|PDE8B_uc003kfc.2_Missense_Mutation_p.P228T|PDE8B_uc003kfd.2_Missense_Mutation_p.P228T|PDE8B_uc003kfe.2_Missense_Mutation_p.P228T	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	228					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GTCAGTCCTTCCTCTTCTCCA	0.498			NA											35	67					1.90571e-15	3.339e-15	0.004289	1	0
Unknown	0	broad.mit.edu	37	5	79655823	79655823	+	Translation_Start_Site	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:79655823G>T	uc003kgo.2	-	1	85	c.-78C>A	c.(-80--76)AGCTG>AGATG							SubName: Full=Putative uncharacterized protein; Flags: Fragment;												NA						AGCTTCCTCAGCTGTTCGGGC	0.498			NA											7	15					1.06961e-07	1.54041e-07	0.00308	1	0
VCAN	1462	broad.mit.edu	37	5	82837667	82837667	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:82837667C>A	uc003kii.3	+	8	9201	c.8845C>A	c.(8845-8847)CCC>ACC	p.P2949T	VCAN_uc003kij.3_Missense_Mutation_p.P1962T|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.P1613T	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2949	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAAGATGTTTCCCACCATTAA	0.428			NA											14	58					3.45872e-05	4.35254e-05	0.004007	1	0
MAN2A1	4124	broad.mit.edu	37	5	109178149	109178149	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:109178149T>G	uc003kou.1	+	17	3650	c.2687T>G	c.(2686-2688)CTA>CGA	p.L896R		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	896	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TATACTGACCTAAATGGGTAC	0.303			NA											13	36					0	0	0.006122	0	0
SRFBP1	153443	broad.mit.edu	37	5	121356095	121356095	+	Missense_Mutation	SNP	C	C	T	rs78373051	by1000genomes	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:121356095C>T	uc003kst.1	+	6	737	c.665C>T	c.(664-666)CCT>CTT	p.P222L		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		CAGAAGACACCTGCTGACCCA	0.413			NA											14	42					0	0	0.003163	0	0
SNX24	28966	broad.mit.edu	37	5	122337653	122337653	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:122337653T>C	uc011cwo.1	+	6	565	c.396T>C	c.(394-396)CCT>CCC	p.P132P	SNX24_uc003ktf.2_Silent_p.P132P|SNX24_uc010jcy.2_Silent_p.P132P	NM_014035	NP_054754	Q9Y343	SNX24_HUMAN	SBBI31 protein	132					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		CCCACCAGCCTGTGCTGCTGT	0.502			NA											27	62					0	0	0.008361	0	0
FBN2	2201	broad.mit.edu	37	5	127673811	127673811	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:127673811A>T	uc003kuu.2	-	27	3915	c.3476T>A	c.(3475-3477)ATT>AAT	p.I1159N	FBN2_uc003kuv.2_Missense_Mutation_p.I1126N	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1159	EGF-like 17; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACATTCGTCAATGTCTGAAAG	0.458			NA											7	13					0	0	0.004482	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181091	140181091	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140181091C>A	uc003lhf.2	+	1	309	c.309C>A	c.(307-309)AGC>AGA	p.S103R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.S103R	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	103	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAGTGCAGCATCCACCTGG	0.547			NA											37	81					2.40579e-17	4.32448e-17	0.00623	1	0
PCDHA10	56139	broad.mit.edu	37	5	140237058	140237058	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140237058G>T	uc003lhx.2	+	1	1425	c.1425G>T	c.(1423-1425)ACG>ACT	p.T475T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.T475T|PCDHA10_uc011dad.1_Silent_p.T475T	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	475	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATCTTCACGGTGTCTGCGT	0.657			NA											30	69					3.11337e-16	5.53489e-16	0.002836	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256592	140256592	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140256592C>T	uc003lic.2	+	1	1662	c.1535C>T	c.(1534-1536)GCG>GTG	p.A512V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.A512V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	512	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGTGCACGCGGAGAGCGGC	0.701	Pancreas(113;759 1672 13322 24104 50104)		NA											22	37					0	0	0.001882	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262359	140262359	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140262359C>A	uc003lif.2	+	1	506	c.506C>A	c.(505-507)ACC>AAC	p.T169N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.T169N|PCDHA13_uc003lid.2_Missense_Mutation_p.T169N	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	169	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGCATTGACCTACCGACTG	0.433	Melanoma(147;1739 1852 5500 27947 37288)		NA											13	34					1.5842e-08	2.37548e-08	0.001855	1	0
PCDHAC1	56135	broad.mit.edu	37	5	140308490	140308490	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140308490G>C	uc003lih.2	+	1	2189	c.2013G>C	c.(2011-2013)TGG>TGC	p.W671C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.W671C	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	671	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGATGTCTGGGAACCAGGAG	0.473			NA											15	144					0	0	0.003163	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476327	140476327	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140476327G>T	uc003lil.2	+	1	2091	c.1953G>T	c.(1951-1953)GAG>GAT	p.E651D	PCDHB2_uc003lim.1_Missense_Mutation_p.E312D	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	651	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAATGGCGAGCCTCCGCGCT	0.721			NA											21	36					9.86323e-18	1.77954e-17	0.003954	1	0
PCDHB4	56131	broad.mit.edu	37	5	140502416	140502416	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140502416G>T	uc003lip.1	+	1	836	c.836G>T	c.(835-837)GGC>GTC	p.G279V		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	279	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTTCTTATGGCTTATTCCAA	0.373			NA											37	64					1.66425e-11	2.72877e-11	0.004878	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553578	140553578	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140553578G>T	uc003lit.2	+	1	1336	c.1162G>T	c.(1162-1164)GAT>TAT	p.D388Y		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	388	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATCCAGGACGATGTCCCCTT	0.468			NA											6	27					0.00198382	0.00217995	0.001984	1	0
PCDHB8	56128	broad.mit.edu	37	5	140558593	140558593	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140558593A>T	uc011dai.1	+	1	1164	c.978A>T	c.(976-978)GGA>GGT	p.G326G	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	326	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGATGCTGGAGGCTTTTCTG	0.418			NA											23	401					0	0	0.00333	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559020	140559020	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140559020C>G	uc011dai.1	+	1	1591	c.1405C>G	c.(1405-1407)CTG>GTG	p.L469V	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	469	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCCCCGCCCTGCACATCGG	0.647			NA											52	233					0	0	0.00361	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559032	140559032	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140559032A>C	uc011dai.1	+	1	1603	c.1417A>C	c.(1417-1419)AGC>CGC	p.S473R	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	473	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACATCGGCAGCGTCAGCGC	0.667			NA											29	252					0	0	0.003755	0	0
TAF7	6879	broad.mit.edu	37	5	140698604	140698604	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140698604G>A	uc003ljg.2	-	1	1748	c.1008C>T	c.(1006-1008)CTC>CTT	p.L336L		NM_005642	NP_005633	Q15545	TAF7_HUMAN	TATA box-binding protein-associated factor 2F	336	Potential.				negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAAGAGCTGAGTTGCTCCT	0.403			NA											9	20					0	0	0.006214	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725056	140725056	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140725056C>G	uc003ljm.1	+	1	1456	c.1456C>G	c.(1456-1458)CGC>GGC	p.R486G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.R246G|PCDHGA3_uc011dap.1_Missense_Mutation_p.R486G	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	486	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACAACGCCCGCATCACTTA	0.552			NA											23	45					0	0	0.002299	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769611	140769611	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140769611C>T	uc003lkc.1	+	1	2160	c.2160C>T	c.(2158-2160)GCC>GCT	p.A720A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.A720A	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	720	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCCCCGCCTCCTGGAGCT	0.562			NA											50	99					0	0	0.00361	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772969	140772969	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140772969G>A	uc003lkd.1	+	1	1487	c.589G>A	c.(589-591)GAG>AAG	p.E197K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.E197K	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	197	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGCTGGAGCGCGCCCT	0.632			NA											10	17					0	0	0.006214	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140780026	140780026	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140780026G>T	uc003lkf.1	+	1	2332	c.2332G>T	c.(2332-2334)GGT>TGT	p.G778C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.G778C|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	778	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATACTTTGTGGTGATTCATC	0.398			NA											40	100					1.61863e-15	2.84628e-15	0.00361	1	0
PCDH1	5097	broad.mit.edu	37	5	141244261	141244261	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:141244261C>A	uc003llq.2	-	3	1752	c.1635G>T	c.(1633-1635)CTG>CTT	p.L545L	PCDH1_uc003llp.2_Silent_p.L545L|PCDH1_uc011dbf.1_Silent_p.L523L	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	545	Extracellular (Potential).|Cadherin 5.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GCTCAGGCTCCAGAGAGTAAA	0.552	Ovarian(132;1609 1739 4190 14731 45037)		NA											14	24					4.3838e-07	6.12554e-07	0.001855	1	0
STK32A	202374	broad.mit.edu	37	5	146658824	146658824	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:146658824G>A	uc010jgn.1	+	4	403	c.123G>A	c.(121-123)CAG>CAA	p.Q41Q	STK32A_uc003lol.3_Silent_p.Q41Q|STK32A_uc003lom.2_Silent_p.Q41Q|STK32A_uc011dbw.1_Silent_p.Q41Q	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	41	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATTGTACAGAAGAATGATA	0.413			NA											11	17					0	0	0.001368	0	0
ABLIM3	22885	broad.mit.edu	37	5	148586668	148586668	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:148586668C>A	uc003lpy.2	+	6	797	c.546C>A	c.(544-546)AGC>AGA	p.S182R	ABLIM3_uc003lpz.1_Missense_Mutation_p.S182R|ABLIM3_uc003lqa.1_Missense_Mutation_p.S190R|ABLIM3_uc003lqb.2_Missense_Mutation_p.S182R|ABLIM3_uc003lqc.1_Missense_Mutation_p.S182R|ABLIM3_uc003lqd.1_Missense_Mutation_p.S182R|ABLIM3_uc003lqf.2_Missense_Mutation_p.S182R|ABLIM3_uc003lqe.1_Missense_Mutation_p.S182R	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	182	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACCTGCAGCGTCATCCTCA	0.622			NA											6	29					3.59834e-05	4.49329e-05	0.001168	1	0
TCOF1	6949	broad.mit.edu	37	5	149751720	149751720	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:149751720A>G	uc003lry.2	+	7	899	c.791A>G	c.(790-792)AAG>AGG	p.K264R	TCOF1_uc003lrw.2_Missense_Mutation_p.K264R|TCOF1_uc011dch.1_Missense_Mutation_p.K264R|TCOF1_uc003lrz.2_Missense_Mutation_p.K264R|TCOF1_uc003lrx.2_Intron|TCOF1_uc003lsa.2_Intron	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	264					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGAGGGCCAAGAAGCCAGAA	0.637			NA											8	18					0	0	0.006214	0	0
FAT2	2196	broad.mit.edu	37	5	150922455	150922455	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:150922455C>A	uc003lue.3	-	9	8246	c.8233G>T	c.(8233-8235)GAC>TAC	p.D2745Y	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2745	Cadherin 24.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCCCTGTGTCTGGGTCTAGG	0.498			NA											26	43					2.41591e-17	4.33198e-17	0.004656	1	0
FAT2	2196	broad.mit.edu	37	5	150932774	150932774	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:150932774C>A	uc003lue.3	-	5	4133	c.4120G>T	c.(4120-4122)GAG>TAG	p.E1374*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1374	Extracellular (Potential).|Cadherin 12.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTCTGCCCTCTACGCTGATG	0.577			NA											11	41					3.07112e-06	4.08734e-06	0.000978	1	0
GRIA1	2890	broad.mit.edu	37	5	153078460	153078460	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:153078460A>C	uc003lva.3	+	10	1644	c.1279A>C	c.(1279-1281)AAT>CAT	p.N427H	GRIA1_uc003luy.3_Missense_Mutation_p.N427H|GRIA1_uc003luz.3_Missense_Mutation_p.N332H|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.N347H|GRIA1_uc011dcx.1_Missense_Mutation_p.N358H|GRIA1_uc011dcy.1_Missense_Mutation_p.N437H|GRIA1_uc011dcz.1_Missense_Mutation_p.N437H|GRIA1_uc010jia.1_Missense_Mutation_p.N407H	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	427	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAGAACGCCAATCAGTTTGA	0.517			NA											12	35					0	0	0.001855	0	0
MAT2B	27430	broad.mit.edu	37	5	162939126	162939126	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:162939126G>T	uc003lzk.2	+	2	290	c.182G>T	c.(181-183)AGA>ATA	p.R61I	MAT2B_uc003lzj.2_Missense_Mutation_p.R50I|MAT2B_uc003lzl.1_Missense_Mutation_p.R61I	NM_013283	NP_037415	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta isoform	61					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			upper_aerodigestive_tract(1)	1	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGTGGTTTCAGAAGAGCAAGA	0.393			NA											27	53					1.26454e-06	1.7288e-06	0.005443	1	0
CCDC99	54908	broad.mit.edu	37	5	169028523	169028523	+	Missense_Mutation	SNP	G	G	T	rs143182474		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:169028523G>T	uc003mae.3	+	11	1843	c.1564G>T	c.(1564-1566)GTG>TTG	p.V522L	CCDC99_uc010jjj.2_Missense_Mutation_p.V451L|CCDC99_uc011deq.1_Missense_Mutation_p.V339L|CCDC99_uc010jjk.2_Missense_Mutation_p.V248L	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	522					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATCTGCCCGTGGATATGCA	0.428			NA											12	31					5.50884e-06	7.18716e-06	0.001368	1	0
CCDC99	54908	broad.mit.edu	37	5	169028583	169028583	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:169028583G>C	uc003mae.3	+	11	1903	c.1624G>C	c.(1624-1626)GCT>CCT	p.A542P	CCDC99_uc010jjj.2_Missense_Mutation_p.A471P|CCDC99_uc011deq.1_Missense_Mutation_p.A359P|CCDC99_uc010jjk.2_Missense_Mutation_p.A268P	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	542					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCCGCTGACGCTGAGGCCTT	0.507			NA											7	25					0	0	0.00308	0	0
CLK4	57396	broad.mit.edu	37	5	178030931	178030931	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:178030931G>A	uc003mjf.1	-	12	1327	c.1219C>T	c.(1219-1221)CGC>TGC	p.R407C	CLK4_uc003mjg.1_Missense_Mutation_p.R371C|CLK4_uc010jku.1_Missense_Mutation_p.R227C|CLK4_uc003mjh.1_Missense_Mutation_p.R227C|CLK4_uc010jkv.1_RNA|CLK4_uc011dgg.1_Intron|CLK4_uc011dgh.1_Missense_Mutation_p.R227C	NM_020666	NP_065717	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	407	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		AAATACTTGCGTTTTCTACAG	0.398			NA											10	18					0	0	0.001368	0	0
RIPK1	8737	broad.mit.edu	37	6	3105950	3105950	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:3105950G>T	uc010jni.2	+	9	1473	c.1241G>T	c.(1240-1242)AGG>ATG	p.R414M	RIPK1_uc003muv.3_Missense_Mutation_p.R251M|RIPK1_uc003muw.3_Missense_Mutation_p.R349M|RIPK1_uc011dhs.1_Missense_Mutation_p.R368M|RIPK1_uc003mux.2_Missense_Mutation_p.R414M	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	414	Poly-Arg.|Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				AGGAGACGCAGGGTCTCCCAT	0.498			NA											13	26					0.00010058	0.000121128	0.001368	1	0
F13A1	2162	broad.mit.edu	37	6	6305623	6305623	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:6305623C>A	uc003mwv.2	-	3	403	c.280G>T	c.(280-282)GAC>TAC	p.D94Y	F13A1_uc011dib.1_Intron	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	94					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTTCTGGGGTCATATGGACGA	0.493			NA											20	43					1.64293e-13	2.78476e-13	0.00333	1	0
HIVEP1	3096	broad.mit.edu	37	6	12161902	12161902	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:12161902G>A	uc003nac.2	+	8	6897	c.6718G>A	c.(6718-6720)GGG>AGG	p.G2240R	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2240					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TTGCTTTTCTGGGGTACACAC	0.547			NA											12	15					0	0	0.001368	0	0
HIST1H2BH	8345	broad.mit.edu	37	6	26252218	26252218	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:26252218G>A	uc003nhh.2	+	1	340	c.340G>A	c.(340-342)GAG>AAG	p.E114K	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	114					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CGCCGTGTCCGAGGGCACTAA	0.537			NA											8	46					0	0	0.004482	0	0
OR2J3	442186	broad.mit.edu	37	6	29080108	29080108	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:29080108G>T	uc011dll.1	+	1	441	c.441G>T	c.(439-441)CTG>CTT	p.L147L		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCACCTGCTGGCTGTGGCTT	0.502			NA											75	92					6.86016e-32	1.29551e-31	0.00361	1	0
OR10C1	442194	broad.mit.edu	37	6	29407951	29407951	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:29407951C>T	uc011dlp.1	+	1	159	c.159C>T	c.(157-159)GCC>GCT	p.A53A	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGATGCTGCCCTCCAGTCCC	0.562			NA											24	55					0	0	0.003954	0	0
BAT1	7919	broad.mit.edu	37	6	31500659	31500659	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:31500659C>A	uc003ntt.2	-	7	1396	c.765G>T	c.(763-765)ACG>ACT	p.T255T	BAT1_uc003ntq.2_5'Flank|BAT1_uc003ntr.2_Silent_p.T62T|BAT1_uc003nts.2_Silent_p.T255T|BAT1_uc011dnn.1_Silent_p.T177T|BAT1_uc003ntu.2_Silent_p.T255T|BAT1_uc003ntv.2_Silent_p.T255T	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	255					intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						GCGTCAACTTCGTCTCATCAT	0.388			NA											3	24					5.9392e-07	8.25141e-07	0.001168	1	0
NOTCH4	4855	broad.mit.edu	37	6	32188337	32188337	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:32188337G>C	uc003obb.2	-	6	1143	c.1004C>G	c.(1003-1005)TCT>TGT	p.S335C	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.S335C	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	335	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCTACCAGCAGAGTTCTGGCA	0.622			NA											18	46					0	0	0.001882	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411630	32411630	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:32411630C>G	uc003obh.2	+	4	789	c.708C>G	c.(706-708)ATC>ATG	p.I236M	HLA-DRA_uc003obi.2_Missense_Mutation_p.I211M	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	236	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						TTGGGACCATCTTCATCATCA	0.537			NA							T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|KaposSarcoma_Familial_Clustering_of				38	46					0	0	0.003755	0	0
SRPK1	6732	broad.mit.edu	37	6	35810348	35810348	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:35810348C>G	uc003olj.2	-	14	1777	c.1654G>C	c.(1654-1656)GAA>CAA	p.E552Q	SRPK1_uc011dtg.1_Missense_Mutation_p.E536Q|SRPK1_uc003olh.2_Missense_Mutation_p.E445Q|SRPK1_uc003oli.2_Missense_Mutation_p.E445Q	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	552	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						GAATGAGGTTCAAACAAATAG	0.418	NSCLC(31;67 978 16289 24856 26454)		NA											5	15					0	0	0.001168	0	0
KIF6	221458	broad.mit.edu	37	6	39387722	39387722	+	Splice_Site	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:39387722A>T	uc003oot.2	-	15	1905	c.1810_splice	c.e15+1	p.G604_splice	KIF6_uc003oos.2_Splice_Site_p.G55_splice|KIF6_uc010jwz.1_Splice_Site|KIF6_uc010jxa.1_Splice_Site_p.G395_splice|KIF6_uc011dua.1_Splice_Site_p.G604_splice|KIF6_uc010jxb.1_Splice_Site_p.G548_splice	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TCATCTGCTTACCAATTTTAC	0.413			NA											26	31					0	0	0.004656	0	0
TBCC	6903	broad.mit.edu	37	6	42713641	42713641	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:42713641G>T	uc003osl.2	-	1	244	c.171C>A	c.(169-171)AGC>AGA	p.S57R		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	57					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			CGAAAAAGTGGCTGTTCTCCT	0.617			NA											11	28					2.27111e-07	3.21042e-07	0.001368	1	0
ABCC10	89845	broad.mit.edu	37	6	43417772	43417772	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:43417772C>A	uc003ouy.1	+	22	4637	c.4422C>A	c.(4420-4422)TTC>TTA	p.F1474L	ABCC10_uc003ouz.1_Missense_Mutation_p.F1446L|ABCC10_uc010jyo.1_Missense_Mutation_p.F580L	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1474	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			ACTCCCTGTTCCAGCAGCTGC	0.642			NA											11	64					5.50884e-06	7.18716e-06	0.001368	1	0
CAPN11	11131	broad.mit.edu	37	6	44144383	44144383	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:44144383G>T	uc003owt.1	+	10	1105	c.1067G>T	c.(1066-1068)GGG>GTG	p.G356V	CAPN11_uc011dvn.1_Missense_Mutation_p.G10V	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	356	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACGGAGGACGGGGAGTTCTGG	0.632			NA											11	24					1.05317e-09	1.64883e-09	0.00245	1	0
DEFB114	245928	broad.mit.edu	37	6	49928016	49928016	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:49928016C>T	uc011dwp.1	-	2	199	c.199G>A	c.(199-201)GAT>AAT	p.D67N		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	67					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					CAAAACATATCATCTTCTTCA	0.358			NA											10	24					0	0	0.008291	0	0
IL17F	112744	broad.mit.edu	37	6	52103604	52103604	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:52103604C>A	uc003pam.1	-	2	249	c.178G>T	c.(178-180)GGC>TGC	p.G60C	IL17F_uc003pal.1_Missense_Mutation_p.G6C	NM_052872	NP_443104	Q96PD4	IL17F_HUMAN	interleukin 17F precursor	60					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			ovary(1)	1	Lung NSC(77;0.116)					TTGATGATGCCAATGTCAAGC	0.493			NA											12	21					9.31168e-06	1.20836e-05	0.001855	1	0
PHF3	23469	broad.mit.edu	37	6	64356528	64356528	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:64356528C>T	uc003pep.1	+	1	98	c.72C>T	c.(70-72)TCC>TCT	p.S24S	PHF3_uc010kaf.1_Silent_p.S24S|PHF3_uc003pem.2_5'UTR|PHF3_uc010kag.1_Intron|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_5'UTR|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Silent_p.S24S	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	24					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTCTAGGATCCAACCTGGAGA	0.393	GBM(135;136 1820 29512 34071 46235)		NA											19	50					0	0	0.010504	0	0
COL19A1	1310	broad.mit.edu	37	6	70850878	70850878	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:70850878T>A	uc003pfc.1	+	20	1596	c.1479T>A	c.(1477-1479)GAT>GAA	p.D493E	COL19A1_uc010kam.1_Missense_Mutation_p.D389E	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	493	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AAAAAGGAGATAGAGTAAGTA	0.358			NA											24	75					0	0	0.005443	0	0
COL19A1	1310	broad.mit.edu	37	6	70890392	70890392	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:70890392C>A	uc003pfc.1	+	44	2869	c.2752C>A	c.(2752-2754)CCA>ACA	p.P918T		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	918	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TTTCCCTGGACCAGAAGGACC	0.408			NA											9	24					1.33987e-11	2.20435e-11	0.008291	1	0
IMPG1	3617	broad.mit.edu	37	6	76744338	76744338	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:76744338C>T	uc003pik.1	-	3	598	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	156					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTAGGCTCACCTGCTGGAGAA	0.502	Pancreas(37;839 1141 2599 26037)		NA											11	30					0	0	0.001368	0	0
MRAP2	112609	broad.mit.edu	37	6	84772676	84772676	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:84772676G>T	uc003pkg.3	+	3	382	c.192G>T	c.(190-192)CTG>CTT	p.L64L	MRAP2_uc010kbo.2_Intron	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	64					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						TTTTTGTGCTGACCTTGCTGA	0.413			NA											12	47					5.50884e-06	7.18716e-06	0.001368	1	0
CGA	1081	broad.mit.edu	37	6	87796049	87796049	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:87796049T>A	uc003plj.1	-	3	293	c.192A>T	c.(190-192)CCA>CCT	p.P64P		NM_000735	NP_000726	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	64					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)	1		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		TGGACCTTAGTGGAGTGGGAT	0.502			NA											18	87					0	0	0.007413	0	0
GABRR1	2569	broad.mit.edu	37	6	89888660	89888660	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:89888660C>A	uc003pna.2	-	10	1724	c.1269G>T	c.(1267-1269)ATG>ATT	p.M423I	GABRR1_uc011dzv.1_Missense_Mutation_p.M400I	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	423	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GCTGCACCATCATCCTGTCGG	0.562			NA											20	58					8.04996e-18	1.4578e-17	0.001882	1	0
SIM1	6492	broad.mit.edu	37	6	100898177	100898177	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:100898177G>A	uc003pqj.3	-	3	521	c.314C>T	c.(313-315)TCA>TTA	p.S105L	SIM1_uc010kcu.2_Missense_Mutation_p.S105L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	105	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGCTGTCTCTGAGATGTACAT	0.542			NA											23	82					0	0	0.00632	0	0
ASCC3	10973	broad.mit.edu	37	6	100964152	100964152	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:100964152G>T	uc003pqk.2	-	39	6308	c.5979C>A	c.(5977-5979)ATC>ATA	p.I1993I		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1993					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GAAGGGACTCGATGGAGGTCC	0.448			NA											16	47					1.15088e-07	1.64282e-07	0.004007	1	0
RFPL4B	442247	broad.mit.edu	37	6	112671283	112671283	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:112671283G>T	uc003pvx.1	+	3	685	c.373G>T	c.(373-375)GAT>TAT	p.D125Y		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	125	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		GATCCACCACGATCTGACAAA	0.542			NA											12	38					0.000219431	0.000260597	0.00245	1	0
FAM26E	254228	broad.mit.edu	37	6	116837003	116837003	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:116837003G>T	uc003pwy.2	+	2	833	c.781G>T	c.(781-783)GCC>TCC	p.A261S	BET3L_uc011ebh.1_Intron	NM_153711	NP_714922	Q8N5C1	FA26E_HUMAN	hypothetical protein LOC254228	261						integral to membrane					0		all_cancers(87;0.0608)|all_epithelial(87;0.05)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0242)|all cancers(137;0.0419)|OV - Ovarian serous cystadenocarcinoma(136;0.0671)|Epithelial(106;0.212)		TACGTTTGCTGCCTGGGAGGC	0.483			NA											9	40					0.000274275	0.000319476	0.004482	1	0
RFX6	222546	broad.mit.edu	37	6	117244365	117244365	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:117244365C>A	uc003pxm.2	+	14	1596	c.1533C>A	c.(1531-1533)ACC>ACA	p.T511T		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	511					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ATAATCTCACCTTGAACAATG	0.343			NA											18	45					4.96729e-08	7.26872e-08	0.008871	1	0
PTPRK	5796	broad.mit.edu	37	6	128294835	128294835	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:128294835C>A	uc003qbk.2	-	28	4471	c.4104G>T	c.(4102-4104)GGG>GGT	p.G1368G	PTPRK_uc003qbj.2_Silent_p.G1369G|PTPRK_uc010kfc.2_Silent_p.G1375G|PTPRK_uc011ebu.1_Silent_p.G1391G	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1368	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCCGGCCTTCCCCTTCCTCGC	0.483			NA											15	34					2.32078e-09	3.57952e-09	0.003163	1	0
LAMA2	3908	broad.mit.edu	37	6	129513901	129513901	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:129513901A>G	uc003qbn.2	+	12	1790	c.1685A>G	c.(1684-1686)GAC>GGC	p.D562G	LAMA2_uc003qbo.2_Missense_Mutation_p.D562G	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	562	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GACGACTTGGACTCACCTCAG	0.557			NA											6	12					0	0	0.001168	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762366	130762366	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:130762366G>A	uc003qca.2	+	3	1670	c.799G>A	c.(799-801)GAT>AAT	p.D267N	TMEM200A_uc010kfh.2_Missense_Mutation_p.D267N|TMEM200A_uc010kfi.2_Missense_Mutation_p.D267N|TMEM200A_uc003qcb.2_Missense_Mutation_p.D267N	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	267	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GACAACTGATGATAAGACCAG	0.433			NA											16	38					0	0	0.007413	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599485	136599485	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:136599485C>A	uc003qgx.1	-	4	787	c.534G>T	c.(532-534)CCG>CCT	p.P178P	BCLAF1_uc003qgw.1_Silent_p.P178P|BCLAF1_uc003qgy.1_Silent_p.P176P|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.P176P	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	178					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TACTTTTCAACGGACTCTCTT	0.413	Colon(142;1534 1789 5427 7063 28491)		NA											19	164					2.35188e-11	3.84757e-11	0.006122	1	0
BCLAF1	9774	broad.mit.edu	37	6	136600958	136600958	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:136600958C>A	uc003qgx.1	-	3	300	c.47G>T	c.(46-48)AGA>ATA	p.R16I	BCLAF1_uc003qgw.1_Missense_Mutation_p.R16I|BCLAF1_uc003qgy.1_Missense_Mutation_p.R16I|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R16I	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	16					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGACTGTGATCTAGACTTTGA	0.308	Colon(142;1534 1789 5427 7063 28491)		NA											8	48					0.000442599	0.000512261	0.006214	1	0
UTRN	7402	broad.mit.edu	37	6	144757093	144757093	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:144757093A>T	uc003qkt.2	+	9	970	c.878A>T	c.(877-879)CAT>CTT	p.H293L	UTRN_uc010khq.1_Missense_Mutation_p.H293L	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	293	Interaction with SYNM.|Spectrin 1.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAGGAGGAGCATGAGAGTCCC	0.493			NA											8	14					0	0	0.004482	0	0
SHPRH	257218	broad.mit.edu	37	6	146275911	146275911	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:146275911C>T	uc003qlf.2	-	2	947	c.548G>A	c.(547-549)GGT>GAT	p.G183D	SHPRH_uc003qld.2_Missense_Mutation_p.G183D|SHPRH_uc003qle.2_Missense_Mutation_p.G183D|SHPRH_uc003qlg.1_Translation_Start_Site|SHPRH_uc003qlj.1_Missense_Mutation_p.G72D|SHPRH_uc003qlk.1_Missense_Mutation_p.G183D	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	183					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TAACATTTCACCACTGAAGGA	0.358			NA											12	50					0	0	0.001855	0	0
STXBP5	134957	broad.mit.edu	37	6	147680374	147680374	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:147680374G>T	uc003qlz.2	+	23	2621	c.2460G>T	c.(2458-2460)ACG>ACT	p.T820T	STXBP5_uc010khz.1_Silent_p.T784T|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.T475T	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	820	WD 11.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTGGAACAACGCTAGGAACAG	0.493			NA											9	34					4.68919e-08	6.87559e-08	0.008291	1	0
IGF2R	3482	broad.mit.edu	37	6	160517644	160517644	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:160517644G>T	uc003qta.2	+	45	6977	c.6829G>T	c.(6829-6831)GTG>TTG	p.V2277L		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2277	15.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CACCTCAGCCGTGTGTCCTCT	0.512			NA											9	32					0.000673444	0.000757755	0.008291	1	0
LPA	4018	broad.mit.edu	37	6	160978466	160978466	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:160978466G>A	uc003qtl.2	-	30	4889	c.4769C>T	c.(4768-4770)CCC>CTC	p.P1590L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4098	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AACAACAGTGGGAGTCTCTAG	0.473			NA											29	59					0	0	0.002096	0	0
LPA	4018	broad.mit.edu	37	6	161010597	161010597	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:161010597T>A	uc003qtl.2	-	25	4055	c.3935A>T	c.(3934-3936)TAC>TTC	p.Y1312F		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3820	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATTTGGGTAGTATTCTGTGGT	0.463			NA											9	24					0	0	0.006214	0	0
PLG	5340	broad.mit.edu	37	6	161162348	161162348	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:161162348C>T	uc003qtm.3	+	17	2087	c.2024C>T	c.(2023-2025)GCC>GTC	p.A675V		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	675	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TTCAGTCCTGCCGTCATCACT	0.527			NA											7	33					0	0	0.001984	0	0
MAP3K4	4216	broad.mit.edu	37	6	161530849	161530849	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:161530849G>T	uc003qtn.2	+	23	4441	c.4299G>T	c.(4297-4299)CTG>CTT	p.L1433L	MAP3K4_uc010kkc.1_Silent_p.L1429L|MAP3K4_uc003qto.2_Silent_p.L1383L|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Silent_p.L886L|MAP3K4_uc003qtp.2_Silent_p.L369L|MAP3K4_uc003qtq.2_Silent_p.L122L	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1433	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TGTCAAGGCTGGGACTTCAGG	0.468			NA											15	33					3.27435e-08	4.82536e-08	0.00245	1	0
TCP10L2	401285	broad.mit.edu	37	6	167591995	167591995	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:167591995G>T	uc010kkp.2	+	5	753	c.622G>T	c.(622-624)GGT>TGT	p.G208C		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	208											0						GCCGACTCCCGGTGCAGAAAG	0.522			NA											13	50					4.7546e-09	7.28706e-09	0.004007	1	0
UNC93A	54346	broad.mit.edu	37	6	167719471	167719471	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:167719471C>G	uc003qvq.2	+	6	1084	c.909C>G	c.(907-909)GAC>GAG	p.D303E	UNC93A_uc003qvr.2_Missense_Mutation_p.D261E	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	303	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGGCCACTGACGCGCTGTGCT	0.607			NA											31	110					0	0	0.002836	0	0
CARD11	84433	broad.mit.edu	37	7	2984049	2984049	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:2984049C>A	uc003smv.2	-	5	885	c.481G>T	c.(481-483)GAT>TAT	p.D161Y		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	161	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTCTTCTCATCCTCCAGCTGC	0.577			NA	Mis		DLBCL								10	98					4.3838e-07	6.12554e-07	0.001855	1	0
C1GALT1	56913	broad.mit.edu	37	7	7283162	7283162	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:7283162G>T	uc010ktn.2	+	4	1119	c.896G>T	c.(895-897)GGT>GTT	p.G299V	C1GALT1_uc003sra.2_Missense_Mutation_p.G299V|uc003srb.1_5'Flank	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	299	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TAGGGTCCTGGTTGCTGCTCT	0.338			NA											18	99					1.2644e-06	1.7288e-06	0.010504	1	0
SCIN	85477	broad.mit.edu	37	7	12679984	12679984	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:12679984C>T	uc003ssn.3	+	11	1633	c.1423C>T	c.(1423-1425)CAA>TAA	p.Q475*	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Nonsense_Mutation_p.Q228*	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	475	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CCGAGTCTCCCAAGGCAAAGA	0.418			NA											9	13					0	0	0.006214	0	0
TMEM195	392636	broad.mit.edu	37	7	15240919	15240919	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:15240919A>T	uc003stb.1	-	13	1499	c.1329T>A	c.(1327-1329)CCT>CCA	p.P443P		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	443					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						GTTATTTCCAAGGGTGAGAGG	0.303			NA											16	30					0	0	0.008871	0	0
TMEM195	392636	broad.mit.edu	37	7	15584536	15584536	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:15584536C>G	uc003stb.1	-	3	440	c.270G>C	c.(268-270)AGG>AGC	p.R90S		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	90					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						GTTCAATGCTCCTGAAAAATA	0.313			NA											16	70					0	0	0.004007	0	0
TMEM195	392636	broad.mit.edu	37	7	15601446	15601446	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:15601446C>A	uc003stb.1	-	1	195	c.25G>T	c.(25-27)GAT>TAT	p.D9Y		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	9					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						ACTGAAACATCCTGCTGGGCT	0.428			NA											18	51					6.49762e-13	1.08992e-12	0.006122	1	0
FERD3L	222894	broad.mit.edu	37	7	19184799	19184799	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:19184799C>T	uc003suo.1	-	1	246	c.187G>A	c.(187-189)GAA>AAA	p.E63K	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	63	Poly-Glu.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						tcctcttcttctgggtccccc	0.378			NA											3	22					0	0	0.009096	0	0
ABCB5	340273	broad.mit.edu	37	7	20721224	20721224	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:20721224G>T	uc003suw.3	+	6	1015	c.469G>T	c.(469-471)GAG>TAG	p.E157*	ABCB5_uc010kuh.2_Nonsense_Mutation_p.E602*	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	157	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AATGCTGGCGGAGAAAGGAGC	0.448			NA											16	57					1.33834e-09	2.07964e-09	0.007413	1	0
DNAH11	8701	broad.mit.edu	37	7	21639422	21639422	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:21639422C>T	uc003svc.2	+	15	2716	c.2685C>T	c.(2683-2685)TTC>TTT	p.F895F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	895	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGAAGCTCTTCAAAGCCAATC	0.338			NA							Kartagener_syndrome				5	17					0	0	0.000602	0	0
CLK2P	1197	broad.mit.edu	37	7	23625071	23625071	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:23625071G>A	uc003swk.2	-	1	1076	c.426C>T	c.(424-426)ATC>ATT	p.I142I		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						ACTCAAAGATGATGCAGCCTA	0.512			NA											9	25					0	0	0.004482	0	0
HOXA5	3202	broad.mit.edu	37	7	27183050	27183050	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:27183050C>A	uc003syn.1	-	1	238	c.177G>T	c.(175-177)TCG>TCT	p.S59S		NM_019102	NP_061975	P20719	HXA5_HUMAN	homeobox A5	59					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCCGGAGCCCGAGCGGCCGA	0.687	Colon(119;75 2200 7557 42868)		NA											5	28					8.12818e-05	9.82943e-05	0.001984	1	0
EVX1	2128	broad.mit.edu	37	7	27285713	27285713	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:27285713C>T	uc003szd.1	+	3	1379	c.893C>T	c.(892-894)TCG>TTG	p.S298L	EVX1_uc011jzn.1_Missense_Mutation_p.S116L|EVX1_uc010kuy.1_3'UTR	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	298						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GCCGCCGCCTCGCCCTTCAGC	0.771			NA											4	5					0	0	0.009096	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31125054	31125054	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:31125054C>T	uc003tca.1	+	9	889	c.666C>T	c.(664-666)TCC>TCT	p.S222S	ADCYAP1R1_uc003tcb.1_Silent_p.S201S|ADCYAP1R1_uc003tcc.1_Silent_p.S222S|ADCYAP1R1_uc003tcd.1_Silent_p.S222S|ADCYAP1R1_uc003tce.1_Silent_p.S222S|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	222	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GCTTCATCTCCACTGTGAGTG	0.557	Ovarian(44;225 1186 2158 11092)		NA											23	61					0	0	0.004656	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31126008	31126008	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:31126008A>T	uc003tca.1	+	10	903	c.680A>T	c.(679-681)AAG>ATG	p.K227M	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.K206M|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.K227M|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.K227M|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.K227M|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	227	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GTGGAATGTAAGGCCGTCATG	0.567	Ovarian(44;225 1186 2158 11092)		NA											8	23					0	0	0.004482	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35142703	35142703	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:35142703G>C	uc003teq.1	-	19	1960	c.853C>G	c.(853-855)CTC>GTC	p.L285V	DPY19L2P1_uc003tep.1_Intron|DPY19L2P1_uc010kwz.1_Intron					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						CAGCCAAAGAGCTGAAACGAA	0.358			NA											7	21					0	0	0.001984	0	0
TARP	445347	broad.mit.edu	37	7	38305109	38305109	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:38305109G>A	uc003tge.1	-	5	975	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_5'UTR|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						TTCCCCTCCTGGGATCCCAGA	0.423			NA											67	80					0	0	0.00361	0	0
CDK13	8621	broad.mit.edu	37	7	40037171	40037171	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:40037171G>T	uc003thh.3	+	3	2232	c.1950G>T	c.(1948-1950)CCG>CCT	p.P650P	CDK13_uc003thi.3_Silent_p.P650P|CDK13_uc011kbf.1_Silent_p.P36P	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	650					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						CTGATTTACCGCTGCCCCCTG	0.408			NA											46	89					6.31075e-24	1.17801e-23	0.00361	1	0
INHBA	3624	broad.mit.edu	37	7	41729730	41729730	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:41729730C>A	uc003thq.2	-	2	1034	c.799G>T	c.(799-801)GGG>TGG	p.G267W	INHBA_uc003thr.2_Missense_Mutation_p.G267W	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	267					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						ttcccttccccctcctcttct	0.363			NA								TSP Lung(11;0.080)			7	27					0.00198382	0.00217995	0.001984	1	0
HECW1	23072	broad.mit.edu	37	7	43484068	43484068	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:43484068G>A	uc003tid.1	+	11	1902	c.1297G>A	c.(1297-1299)GTG>ATG	p.V433M	HECW1_uc011kbi.1_Missense_Mutation_p.V433M	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	433					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CATGGTCTCTGTGGGACCTGA	0.622			NA											7	19					0	0	0.001984	0	0
AEBP1	165	broad.mit.edu	37	7	44153462	44153462	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:44153462C>A	uc003tkb.2	+	21	3384	c.3079C>A	c.(3079-3081)CTG>ATG	p.L1027M	AEBP1_uc003tkc.3_Missense_Mutation_p.L602M|AEBP1_uc003tkd.2_Missense_Mutation_p.L277M	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	1027	Required for transcriptional repression (By similarity).|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACAACACCGCCTGCGGCTTCG	0.687			NA											16	49					8.34094e-07	1.14354e-06	0.008871	1	0
ADCY1	107	broad.mit.edu	37	7	45743059	45743059	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:45743059C>T	uc003tne.3	+	15	2557	c.2539C>T	c.(2539-2541)CAG>TAG	p.Q847*		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	847	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCACGTCGCCCAGCACTTCCT	0.622			NA											4	20					0	0	0.001168	0	0
PKD1L1	168507	broad.mit.edu	37	7	47930295	47930295	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:47930295G>T	uc003tny.1	-	16	2520	c.2520C>A	c.(2518-2520)CAC>CAA	p.H840Q		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	840	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CATCCAGTTGGTGTGCAGTGG	0.587			NA											7	38					2.0095e-06	2.69165e-06	0.001984	1	0
FIGNL1	63979	broad.mit.edu	37	7	50514903	50514903	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:50514903C>A	uc003tpc.2	-	4	460	c.83G>T	c.(82-84)GGA>GTA	p.G28V	FIGNL1_uc003tpb.2_5'UTR|FIGNL1_uc003tpd.2_Missense_Mutation_p.G28V|FIGNL1_uc003tpe.2_Missense_Mutation_p.G28V|FIGNL1_uc010kyy.2_Missense_Mutation_p.G28V	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	28					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TGCCTTCGGTCCGGTACATAT	0.443			NA											13	36					1.61879e-10	2.59577e-10	0.001368	1	0
POM121L12	285877	broad.mit.edu	37	7	53103830	53103830	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:53103830C>A	uc003tpz.2	+	1	482	c.466C>A	c.(466-468)CAG>AAG	p.Q156K		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	156											0						ATCCCCTGGACAGAGAgcccg	0.597			NA											7	19					8.12818e-05	9.82943e-05	0.001984	1	0
ZNF679	168417	broad.mit.edu	37	7	63726720	63726720	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:63726720G>C	uc003tsx.2	+	5	978	c.709G>C	c.(709-711)GAG>CAG	p.E237Q		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCATACTGGAGAGAAACCCTA	0.403			NA											6	22					0	0	0.001168	0	0
LOC168474	168474	broad.mit.edu	37	7	64313234	64313234	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:64313234G>T	uc003ttj.1	-	1	945	c.393C>A	c.(391-393)CCC>CCA	p.P131P		NR_002789				SubName: Full=Selenophosphate synthetase 1; SubName: Full=Selenophosphate synthetase 1, isoform CRA_a;												0						GGACAATCCAGGGGTTTAGTA	0.483			NA											6	13					0.00116845	0.00130265	0.001168	1	0
WBSCR17	64409	broad.mit.edu	37	7	71142239	71142239	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:71142239C>A	uc003tvy.2	+	9	1448	c.1448C>A	c.(1447-1449)CCG>CAG	p.P483Q	WBSCR17_uc003tvz.2_Missense_Mutation_p.P182Q	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	483	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GACCAGGGGCCGCTGGAGAAC	0.532			NA											35	155					6.97489e-18	1.26469e-17	0.004878	1	0
MLXIPL	51085	broad.mit.edu	37	7	73008622	73008622	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:73008622G>C	uc003tyn.1	-	16	2470	c.2422C>G	c.(2422-2424)CTG>GTG	p.L808V	MLXIPL_uc003tyj.1_Missense_Mutation_p.L187V|MLXIPL_uc003tyk.1_Missense_Mutation_p.L787V|MLXIPL_uc003tyl.1_Missense_Mutation_p.L806V|MLXIPL_uc003tym.1_Missense_Mutation_p.L789V|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.L714V	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	808					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGAGCGGGCAGAGAGCAGTAC	0.627			NA											9	62					0	0	0.008291	0	0
MAGI2	9863	broad.mit.edu	37	7	78150938	78150938	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:78150938G>T	uc003ugx.2	-	4	817	c.563C>A	c.(562-564)CCG>CAG	p.P188Q	MAGI2_uc003ugy.2_Missense_Mutation_p.P188Q|MAGI2_uc011kgr.1_Missense_Mutation_p.P20Q|MAGI2_uc011kgs.1_Missense_Mutation_p.P25Q	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	188	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TTCTGCTGGCGGCTTTGGGGT	0.393			NA											30	158					2.47511e-08	3.6773e-08	0.008361	1	0
PCLO	27445	broad.mit.edu	37	7	82544170	82544170	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:82544170C>A	uc003uhx.2	-	7	13421	c.13132G>T	c.(13132-13134)GCT>TCT	p.A4378S	PCLO_uc003uhv.2_Missense_Mutation_p.A4378S|PCLO_uc010lec.2_Missense_Mutation_p.A1343S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4309					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGGGGTCCAGCTGCAGCCCTG	0.512			NA											7	34					8.12818e-05	9.82943e-05	0.001984	1	0
PCLO	27445	broad.mit.edu	37	7	82545171	82545171	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:82545171C>T	uc003uhx.2	-	7	12420	c.12131G>A	c.(12130-12132)CGA>CAA	p.R4044Q	PCLO_uc003uhv.2_Missense_Mutation_p.R4044Q|PCLO_uc010lec.2_Missense_Mutation_p.R1009Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3975					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GACATAATTTCGTGGAGTATG	0.408			NA											21	30					0	0	0.008871	0	0
SEMA3A	10371	broad.mit.edu	37	7	83739857	83739857	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:83739857G>C	uc003uhz.2	-	4	697	c.382C>G	c.(382-384)CAC>GAC	p.H128D		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	128	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						GCGTACAAGTGAGTCTGATTA	0.383			NA											14	73					0	0	0.001855	0	0
SEMA3D	223117	broad.mit.edu	37	7	84642099	84642099	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:84642099G>T	uc003uic.2	-	15	1807	c.1767C>A	c.(1765-1767)GAC>GAA	p.D589E	SEMA3D_uc010led.2_Missense_Mutation_p.D589E|SEMA3D_uc003uib.2_Missense_Mutation_p.D228E	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	589					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TGTACTTACTGTCTTCGATGT	0.383	Ovarian(63;442 1191 17318 29975 31528)		NA											9	66					1.58986e-06	2.14735e-06	0.008291	1	0
C7orf63	79846	broad.mit.edu	37	7	89874756	89874756	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:89874756C>G	uc010lep.2	+	1	269	c.18C>G	c.(16-18)GCC>GCG	p.A6A	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Silent_p.A6A|C7orf63_uc010leo.2_Silent_p.A6A	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	6							binding			ovary(1)	1						CAGAGGAAGCCGGGGCGACCG	0.677			NA											25	38					0	0	0.004656	0	0
ANKIB1	54467	broad.mit.edu	37	7	92015853	92015853	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:92015853G>A	uc003ulw.2	+	12	2024	c.1648G>A	c.(1648-1650)GAA>AAA	p.E550K	ANKIB1_uc010lew.1_5'UTR	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	550							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GATTTGCCTTGAAGAGTGGAA	0.378			NA											3	9					0	0	0.009096	0	0
C7orf64	84060	broad.mit.edu	37	7	92161862	92161862	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:92161862A>T	uc003ulz.2	+	3	488	c.447A>T	c.(445-447)AAA>AAT	p.K149N	C7orf64_uc011khu.1_Missense_Mutation_p.K149N|C7orf64_uc003uma.2_Missense_Mutation_p.K149N	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	149							nucleotide binding			ovary(2)	2						CTGAAAATAAAGGTATGGAAA	0.194			NA											24	28					0	0	0.00278	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94915575	94915575	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:94915575G>T	uc003unp.2	+	13	3097	c.2815G>T	c.(2815-2817)GGC>TGC	p.G939C	PPP1R9A_uc010lfj.2_Missense_Mutation_p.G1223C|PPP1R9A_uc011kif.1_Missense_Mutation_p.G1145C|PPP1R9A_uc003unq.2_Missense_Mutation_p.G1163C|PPP1R9A_uc011kig.1_Missense_Mutation_p.G939C|PPP1R9A_uc003unr.2_Missense_Mutation_p.G236C	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	939	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGACCTCAGCGGCTTAGGAGC	0.443			NA								HNSCC(28;0.073)			17	47					5.01169e-05	6.18917e-05	0.00499	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95442509	95442509	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:95442509G>T	uc003uoc.3	+	4	502	c.225G>T	c.(223-225)GTG>GTT	p.V75V	DYNC1I1_uc003uod.3_Intron|DYNC1I1_uc003uob.2_Intron|DYNC1I1_uc003uoe.3_Silent_p.V75V|DYNC1I1_uc010lfl.2_Intron	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	75	Interaction with DCTN1 (By similarity).				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CTTCACCAGTGCAGCCGCTGC	0.413			NA											19	122					2.37509e-13	4.01176e-13	0.010504	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95662087	95662087	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:95662087C>T	uc003uoc.3	+	12	1553	c.1276C>T	c.(1276-1278)CCA>TCA	p.P426S	DYNC1I1_uc003uod.3_Missense_Mutation_p.P409S|DYNC1I1_uc003uob.2_Missense_Mutation_p.P389S|DYNC1I1_uc003uoe.3_Missense_Mutation_p.P406S|DYNC1I1_uc010lfl.2_Missense_Mutation_p.P415S	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	426	WD 3.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			GCTCTCAACTCCACAGGTGGG	0.443			NA											8	65					0	0	0.00308	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99117525	99117525	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:99117525G>T	uc003uqv.2	+	4	753	c.629G>T	c.(628-630)GGG>GTG	p.G210V	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.G210V|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.G210V|ZKSCAN5_uc003uqx.2_Intron|ZKSCAN5_uc003uqy.2_5'UTR	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	210					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTCTCAACTGGGTCCCAGGTG	0.537			NA											10	54					2.17888e-05	2.75625e-05	0.006214	1	0
OR2AE1	81392	broad.mit.edu	37	7	99474527	99474527	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:99474527G>A	uc003usc.1	-	1	130	c.130C>T	c.(130-132)CTC>TTC	p.L44F		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGAATGGTGAGGGTGTTGCCA	0.498			NA											16	25					0	0	0.004007	0	0
AGFG2	3268	broad.mit.edu	37	7	100151090	100151090	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100151090G>T	uc003uvf.2	+	4	688	c.552G>T	c.(550-552)CCG>CCT	p.P184P	AGFG2_uc003uvg.1_Intron|AGFG2_uc010lgy.2_Missense_Mutation_p.R46L	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	184					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						ATCCTGCACCGTCTCTCTCAG	0.552			NA											18	51					1.67942e-08	2.5105e-08	0.006122	1	0
AGFG2	3268	broad.mit.edu	37	7	100159952	100159952	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100159952C>T	uc003uvf.2	+	7	1084	c.948C>T	c.(946-948)GAC>GAT	p.D316D	AGFG2_uc010lgy.2_Missense_Mutation_p.T178M	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	316					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						GCCTCGCAGACGTGGGCAGCT	0.637			NA											15	29					0	0	0.010504	0	0
LRCH4	4034	broad.mit.edu	37	7	100176407	100176407	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100176407G>A	uc003uvj.2	-	5	654	c.601C>T	c.(601-603)CTG>TTG	p.L201L	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjw.1_5'UTR|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	201	LRR 7.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGTCCCCCAGCTCTGGAACA	0.622			NA											8	39					0	0	0.00308	0	0
ZAN	7455	broad.mit.edu	37	7	100359848	100359848	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100359848G>T	uc003uwj.2	+	20	4018	c.3853G>T	c.(3853-3855)GGC>TGC	p.G1285C	ZAN_uc003uwk.2_Missense_Mutation_p.G1285C|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_5'UTR	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1285	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CACATACTCTGGCAAACTCTG	0.572			NA											7	20					0.000157383	0.000187214	0.00308	1	0
ZAN	7455	broad.mit.edu	37	7	100383678	100383678	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100383678C>T	uc003uwj.2	+	38	7059	c.6894C>T	c.(6892-6894)GCC>GCT	p.A2298A	ZAN_uc003uwk.2_Silent_p.A2298A|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.A348A	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2298	VWFC 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGGGAGGAGCCATTCAGTGCG	0.572			NA											14	30					0	0	0.003163	0	0
MUC17	140453	broad.mit.edu	37	7	100676939	100676939	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100676939C>A	uc003uxp.1	+	3	2295	c.2242C>A	c.(2242-2244)CCA>ACA	p.P748T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	748	Extracellular (Potential).|Ser-rich.|10.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGAAGCACTCCATTAACAAG	0.493			NA											47	232					3.21987e-24	6.02588e-24	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100678017	100678017	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:100678017C>A	uc003uxp.1	+	3	3373	c.3320C>A	c.(3319-3321)CCT>CAT	p.P1107H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1107	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|16.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAAGTGTGCCTGTCAGCACC	0.502			NA											46	640					1.83347e-19	3.36637e-19	0.00361	1	0
PMPCB	9512	broad.mit.edu	37	7	102939074	102939074	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:102939074G>T	uc003vbl.2	+	2	193	c.159G>T	c.(157-159)CTG>CTT	p.L53L	PMPCB_uc010liu.1_Silent_p.L53L|PMPCB_uc003vbk.1_Silent_p.L53L|PMPCB_uc003vbm.2_5'UTR|PMPCB_uc010liv.2_5'UTR|PMPCB_uc010liw.2_5'UTR|PMPCB_uc011kll.1_5'UTR|PMPCB_uc011klm.1_5'Flank	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	53					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						AAGTTGTTCTGAATGTTCCTG	0.438			NA											40	108					3.54561e-26	6.65258e-26	0.009718	1	0
RELN	5649	broad.mit.edu	37	7	103163867	103163867	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:103163867G>T	uc003vca.2	-	47	7621	c.7461C>A	c.(7459-7461)GGC>GGA	p.G2487G	RELN_uc010liz.2_Silent_p.G2487G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2487	EGF-like 6.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATCTCCCATGGCCACTGCACA	0.458	NSCLC(146;835 1944 15585 22231 52158)		NA											16	94					1.37285e-15	2.41702e-15	0.004007	1	0
RELN	5649	broad.mit.edu	37	7	103368565	103368565	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:103368565C>A	uc003vca.2	-	7	906	c.746G>T	c.(745-747)CGA>CTA	p.R249L	RELN_uc010liz.2_Missense_Mutation_p.R249L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	249					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TACCAGTTCTCGTGGGCCATA	0.403	NSCLC(146;835 1944 15585 22231 52158)		NA											17	32					4.63292e-17	8.2869e-17	0.008871	1	0
MET	4233	broad.mit.edu	37	7	116423428	116423428	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:116423428T>C	uc003vij.2	+	19	3890	c.3703T>C	c.(3703-3705)TAT>CAT	p.Y1235H	MET_uc010lkh.2_Missense_Mutation_p.Y1253H|MET_uc011knj.1_Missense_Mutation_p.Y805H	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1235	Protein kinase.|Interaction with RANBP9.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.Y1253D(47)		upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TAAAGAATACTATAGTGTACA	0.398			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				11	61					0	0	0.000978	0	0
C7orf58	79974	broad.mit.edu	37	7	120876855	120876855	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:120876855C>G	uc003vjq.3	+	17	2590	c.2143C>G	c.(2143-2145)CTA>GTA	p.L715V	C7orf58_uc003vjs.3_Missense_Mutation_p.L715V|C7orf58_uc003vjt.3_Missense_Mutation_p.L495V	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	715						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ACAGTCTGAACTAAAAAGATG	0.353			NA											11	50					0	0	0.000978	0	0
RNF133	168433	broad.mit.edu	37	7	122338680	122338680	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:122338680G>A	uc003vkj.1	-	1	529	c.293C>T	c.(292-294)TCA>TTA	p.S98L	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	98	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						CCAGGTCTCTGAGTACTTTGA	0.448	Colon(198;1778 2057 7449 19869 45985)		NA											28	182					0	0	0.009535	0	0
HYAL4	23553	broad.mit.edu	37	7	123508347	123508347	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:123508347G>T	uc003vlc.2	+	3	658	c.20G>T	c.(19-21)GGA>GTA	p.G7V	HYAL4_uc011knz.1_Missense_Mutation_p.G7V	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	7	Cytoplasmic (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TTATCTGAAGGACAGTTAAAG	0.343			NA											34	69					4.14481e-20	7.67791e-20	0.00623	1	0
FSCN3	29999	broad.mit.edu	37	7	127239547	127239547	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:127239547G>T	uc003vmd.1	+	5	1452	c.1233G>T	c.(1231-1233)CAG>CAT	p.Q411H	FSCN3_uc011koh.1_Missense_Mutation_p.Q277H|FSCN3_uc010llc.1_Missense_Mutation_p.Q411H	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	411						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						AGTGCAACCAGGATCAGCCCG	0.532			NA											20	70					5.35356e-11	8.68983e-11	0.00278	1	0
METTL2B	55798	broad.mit.edu	37	7	128138196	128138196	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:128138196G>C	uc003vnf.2	+	7	953	c.916G>C	c.(916-918)GGT>CGT	p.G306R	METTL2B_uc003vng.2_Missense_Mutation_p.G241R|METTL2B_uc011kop.1_Missense_Mutation_p.G170R	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	306							methyltransferase activity			skin(1)	1						GTTTAAAAAAGGTATTTTGAG	0.318			NA											6	41					0	0	0.001984	0	0
OPN1SW	611	broad.mit.edu	37	7	128414653	128414653	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:128414653G>T	uc003vnt.3	-	3	586	c.586C>A	c.(586-588)CGC>AGC	p.R196S		NM_001708	NP_001699	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	196	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0						GACTCGCTGCGGTATTTGGTG	0.557			NA											13	53					5.50884e-06	7.18716e-06	0.001368	1	0
CPA5	93979	broad.mit.edu	37	7	130007240	130007240	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:130007240C>A	uc010lmd.1	+	12	1486	c.866C>A	c.(865-867)TCA>TAA	p.S289*	CPA5_uc003vps.2_Nonsense_Mutation_p.S289*|CPA5_uc003vpt.2_Nonsense_Mutation_p.S289*|CPA5_uc010lme.1_Nonsense_Mutation_p.S289*|CPA5_uc003vpu.1_Nonsense_Mutation_p.S289*|uc003vpv.1_RNA	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	289					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					AACCCCTGCTCAGAAACTTAT	0.522			NA											4	38					0.00909568	0.00969496	0.009096	1	0
LRGUK	136332	broad.mit.edu	37	7	133884105	133884105	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:133884105C>A	uc003vrm.1	+	14	1695	c.1679C>A	c.(1678-1680)TCC>TAC	p.S560Y		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	560	Guanylate kinase-like.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						TTTGCTGTCTCCAGAGTGGAC	0.363			NA											35	93					1.30998e-17	2.36056e-17	0.005524	1	0
LRGUK	136332	broad.mit.edu	37	7	133948696	133948696	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:133948696C>A	uc003vrm.1	+	20	2463	c.2447C>A	c.(2446-2448)ACC>AAC	p.T816N		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	816							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GTCAAACCCACCCTCCCTCCA	0.498			NA											23	19					1.64293e-13	2.78476e-13	0.00333	1	0
EPHB6	2051	broad.mit.edu	37	7	142564763	142564763	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:142564763C>G	uc011kst.1	+	11	2474	c.1687C>G	c.(1687-1689)CGG>GGG	p.R563G	EPHB6_uc011ksu.1_Missense_Mutation_p.R563G|EPHB6_uc003wbs.2_Missense_Mutation_p.R271G|EPHB6_uc003wbt.2_Missense_Mutation_p.R37G|EPHB6_uc003wbu.2_Missense_Mutation_p.R271G|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	563	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGTGCGGGCCCGGACTGCTGC	0.627			NA											12	45					0	0	0.001368	0	0
TRPV6	55503	broad.mit.edu	37	7	142571321	142571321	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:142571321G>C	uc003wbx.1	-	13	1884	c.1668C>G	c.(1666-1668)AGC>AGG	p.S556R	TRPV6_uc003wbw.1_Missense_Mutation_p.S342R|TRPV6_uc010lou.1_Missense_Mutation_p.S427R	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	556					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CATAGGTGATGCTGTACATGA	0.567			NA											19	68					0	0	0.007413	0	0
CLCN1	1180	broad.mit.edu	37	7	143047529	143047529	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:143047529A>T	uc003wcr.1	+	21	2555	c.2468A>T	c.(2467-2469)CAG>CTG	p.Q823L	CLCN1_uc011ktc.1_Missense_Mutation_p.Q435L	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	823	CBS 2.|Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TGTATTGACCAGTCTCCCTTC	0.562			NA											5	27					0	0	0.000602	0	0
CLCN1	1180	broad.mit.edu	37	7	143047730	143047730	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:143047730G>T	uc003wcr.1	+	22	2665	c.2578G>T	c.(2578-2580)GTC>TTC	p.V860F	CLCN1_uc011ktc.1_Missense_Mutation_p.V472F	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	860	CBS 2.|Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GCTCAGGGGCGTCCTGGCCCT	0.557			NA											20	124					2.37509e-13	4.01176e-13	0.010504	1	0
ZYX	7791	broad.mit.edu	37	7	143078840	143078840	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:143078840G>T	uc003wcw.2	+	2	331	c.176G>T	c.(175-177)CGG>CTG	p.R59L	ZYX_uc011ktd.1_Intron|ZYX_uc003wcx.2_Missense_Mutation_p.R59L|ZYX_uc011kte.1_Missense_Mutation_p.R59L|ZYX_uc011ktf.1_5'Flank	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	59					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CAGATGGGCCGGGTGGGCGAG	0.721			NA											4	8					0.00024832	0.000292993	0.009096	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147092746	147092746	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:147092746C>A	uc003weu.1	+	10	2060	c.1544C>A	c.(1543-1545)CCT>CAT	p.P515H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	515	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTCCTTCAGCCTTCATTCCAA	0.423			NA								HNSCC(39;0.1)			28	115					2.81731e-10	4.47329e-10	0.002096	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147092781	147092781	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:147092781G>T	uc003weu.1	+	10	2095	c.1579G>T	c.(1579-1581)GAC>TAC	p.D527Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	527	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CATTCAAGTGGACGATCAACT	0.428			NA								HNSCC(39;0.1)			30	89					2.61193e-14	4.48464e-14	0.009535	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147259350	147259350	+	Splice_Site	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:147259350G>T	uc003weu.1	+	12	2413	c.1897_splice	c.e12+1	p.E633_splice		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor						behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AACATGACAGGTAACTGTGTC	0.393			NA								HNSCC(39;0.1)			9	64					1.58986e-06	2.14735e-06	0.008291	1	0
CNTNAP2	26047	broad.mit.edu	37	7	148080826	148080826	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:148080826C>A	uc003weu.1	+	22	4077	c.3561C>A	c.(3559-3561)ATC>ATA	p.I1187I	CNTNAP2_uc003wev.1_5'UTR	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1187	Laminin G-like 4.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAACCAGATCGCCCCTCTCA	0.552			NA								HNSCC(39;0.1)			10	31					7.48243e-07	1.03265e-06	0.006214	1	0
SSPO	23145	broad.mit.edu	37	7	149509063	149509063	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:149509063G>A	uc010lpk.2	+	69	9609	c.9609G>A	c.(9607-9609)CGG>CGA	p.R3203R		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3203	TSP type-1 11.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTGCCCGGTGCCATCGGC	0.697			NA											3	24					0	0	0.004672	0	0
SSPO	23145	broad.mit.edu	37	7	149521636	149521636	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:149521636C>T	uc010lpk.2	+	96	13715	c.13715C>T	c.(13714-13716)TCA>TTA	p.S4572L	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4572					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGCTGGCTTCAGAGCAGCAC	0.711			NA											8	24					0	0	0.004482	0	0
MLL3	58508	broad.mit.edu	37	7	151970887	151970887	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:151970887C>A	uc003wla.2	-	7	1134	c.915G>T	c.(913-915)ATG>ATT	p.M305I		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	305					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GATAATGATACATCTGGGTAC	0.433	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								5	110					1.23904e-05	1.57558e-05	0.000602	1	0
DPP6	1804	broad.mit.edu	37	7	154684122	154684122	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:154684122G>T	uc003wlk.2	+	26	2659	c.2530G>T	c.(2530-2532)GTG>TTG	p.V844L	DPP6_uc003wli.2_Missense_Mutation_p.V780L|DPP6_uc003wlm.2_Missense_Mutation_p.V782L|DPP6_uc011kvq.1_Missense_Mutation_p.V737L	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	844	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CAACTTCTTCGTGGAATGCTT	0.512	NSCLC(125;1384 1783 2490 7422 34254)		NA											10	44					3.86212e-05	4.78167e-05	0.008291	1	0
PTPRN2	5799	broad.mit.edu	37	7	157414075	157414075	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:157414075G>T	uc003wno.2	-	15	2444	c.2323C>A	c.(2323-2325)CGC>AGC	p.R775S	PTPRN2_uc003wnp.2_Missense_Mutation_p.R758S|PTPRN2_uc003wnq.2_Missense_Mutation_p.R746S|PTPRN2_uc003wnr.2_Missense_Mutation_p.R737S|PTPRN2_uc011kwa.1_Missense_Mutation_p.R798S	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	775	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCCAGGGAGCGGTTCTTGGGC	0.657			NA											41	165					1.96642e-18	3.58785e-18	0.006999	1	0
MYOM2	9172	broad.mit.edu	37	8	2044234	2044234	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:2044234A>T	uc003wpx.3	+	18	2411	c.2273A>T	c.(2272-2274)CAC>CTC	p.H758L	MYOM2_uc011kwi.1_Missense_Mutation_p.H183L	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	758	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAAAACTGGCACGAGGTCAAT	0.498			NA											6	37					0	0	0.001168	0	0
CSMD1	64478	broad.mit.edu	37	8	2944759	2944759	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:2944759T>C	uc011kwk.1	-	49	7727	c.7337A>G	c.(7336-7338)AAC>AGC	p.N2446S	CSMD1_uc011kwj.1_Missense_Mutation_p.N1775S|CSMD1_uc010lrg.2_Missense_Mutation_p.N514S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2446	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCAGTCCTGTTTAGAATACC	0.493			NA											16	49					0	0	0.00499	0	0
Unknown	0	broad.mit.edu	37	8	7808224	7808224	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:7808224C>G	uc010lro.1	+	6	555	c.273C>G	c.(271-273)TCC>TCG	p.S91S		NM_001039615	NP_001034704			zinc finger protein 705D												NA						ACATGATATCCATGCATCCTA	0.328			NA											18	40					0	0	0.006122	0	0
C8orf74	203076	broad.mit.edu	37	8	10555378	10555378	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:10555378C>G	uc003wtd.1	+	3	540	c.511C>G	c.(511-513)CTG>GTG	p.L171V	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	171											0				COAD - Colon adenocarcinoma(149;0.0811)		GGTGGCCACACTGACGGAGGC	0.682			NA											4	28					0	0	0.000602	0	0
C8orf79	57604	broad.mit.edu	37	8	12878740	12878740	+	Silent	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:12878740A>C	uc010lsq.2	+	5	1044	c.552A>C	c.(550-552)CCA>CCC	p.P184P	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Silent_p.P97P|C8orf79_uc010lsr.2_Silent_p.P58P	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	184							methyltransferase activity				0						GTGGATACCCAGAAAGAGGCC	0.522			NA											9	64					0	0	0.004482	0	0
DLC1	10395	broad.mit.edu	37	8	13357316	13357316	+	Missense_Mutation	SNP	C	C	A	rs150090193		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:13357316C>A	uc003wwm.2	-	2	709	c.265G>T	c.(265-267)GAC>TAC	p.D89Y	DLC1_uc003wwn.2_Missense_Mutation_p.D89Y|DLC1_uc011kxy.1_Missense_Mutation_p.D89Y	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	89					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCATGGCTGTCATTTTCGTCC	0.443			NA											44	211					2.46787e-29	4.64841e-29	0.00361	1	0
BMP1	649	broad.mit.edu	37	8	22065020	22065020	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:22065020C>T	uc003xbg.2	+	18	2810	c.2566C>T	c.(2566-2568)CAC>TAC	p.H856Y	BMP1_uc011kzc.1_Missense_Mutation_p.H605Y|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	856	CUB 4.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		CCAGGCCTCCCACGCCACAGG	0.602			NA											11	27					0	0	0.008291	0	0
NEFM	4741	broad.mit.edu	37	8	24774647	24774647	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:24774647C>T	uc003xed.3	+	3	1312	c.1279C>T	c.(1279-1281)CGA>TGA	p.R427*	NEFM_uc011lac.1_Nonsense_Mutation_p.R427*|NEFM_uc010lue.2_Nonsense_Mutation_p.R51*	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	427	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GTATACACACCGACCCCCAAT	0.443			NA											8	30					0	0	0.004482	0	0
EBF2	64641	broad.mit.edu	37	8	25715978	25715978	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:25715978G>C	uc003xes.1	-	14	1402	c.1385C>G	c.(1384-1386)TCT>TGT	p.S462C	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	462	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGAGCTGGAAGAGTATCCCCG	0.517	Esophageal Squamous(166;1018 1046 3854 8328 13429 13634 14071 26624 32918)		NA											8	39					0	0	0.006214	0	0
FZD3	7976	broad.mit.edu	37	8	28360629	28360629	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:28360629G>T	uc003xgx.2	+	3	577	c.99G>T	c.(97-99)TTG>TTT	p.L33F	FZD3_uc010lvb.2_Missense_Mutation_p.L33F	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	33	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		CTATTACCTTGAGGATGTGCC	0.433			NA											14	71					1.33834e-09	2.07964e-09	0.007413	1	0
NRG1	3084	broad.mit.edu	37	8	32585597	32585597	+	Splice_Site	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:32585597G>A	uc003xiv.2	+	6	1149	c.632_splice	c.e6+1	p.K211_splice	NRG1_uc003xip.2_Splice_Site_p.K392_splice|NRG1_uc003xir.2_Silent_p.K211K|NRG1_uc010lvl.2_Silent_p.K194K|NRG1_uc010lvm.2_Silent_p.K177K|NRG1_uc010lvn.2_Splice_Site_p.K177_splice|NRG1_uc003xis.2_Splice_Site_p.K211_splice|NRG1_uc011lbf.1_Splice_Site_p.K211_splice|NRG1_uc010lvo.2_Splice_Site_p.K211_splice|NRG1_uc003xiu.2_Splice_Site_p.K211_splice|NRG1_uc003xiw.2_Splice_Site_p.K211_splice|NRG1_uc003xit.2_Splice_Site_p.K211_splice|NRG1_uc010lvr.2_Splice_Site|NRG1_uc010lvs.2_Splice_Site|NRG1_uc010lvp.2_Splice_Site_p.K160_splice|NRG1_uc010lvq.2_Splice_Site_p.K143_splice|NRG1_uc003xix.2_Splice_Site_p.K101_splice|NRG1_uc003xiy.2_Splice_Site_p.K266_splice|NRG1_uc010lvt.2_Intron|NRG1_uc011lbg.1_Splice_Site_p.K57_splice|NRG1_uc011lbh.1_Splice_Site_p.K57_splice|NRG1_uc003xiz.1_Splice_Site|NRG1_uc003xja.2_Splice_Site_p.K14_splice	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha						activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ACTTGTGCAAGTAAGAAAAGA	0.388			NA											12	39					0	0	0.000978	0	0
NRG1	3084	broad.mit.edu	37	8	32617782	32617782	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:32617782G>A	uc003xiv.2	+	11	1643	c.1126G>A	c.(1126-1128)GTA>ATA	p.V376I	NRG1_uc011lbf.1_Missense_Mutation_p.V373I|NRG1_uc010lvo.2_Missense_Mutation_p.V373I|NRG1_uc003xiu.2_Missense_Mutation_p.V381I|NRG1_uc003xiw.2_Missense_Mutation_p.V373I|NRG1_uc003xit.2_Missense_Mutation_p.V376I|NRG1_uc010lvr.2_Missense_Mutation_p.V118I|NRG1_uc010lvs.2_Missense_Mutation_p.V118I|NRG1_uc010lvp.2_Missense_Mutation_p.V330I|NRG1_uc010lvq.2_Missense_Mutation_p.V313I|NRG1_uc011lbg.1_Missense_Mutation_p.V222I|NRG1_uc011lbh.1_Missense_Mutation_p.V219I|NRG1_uc003xja.2_Missense_Mutation_p.V187I	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	376	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GATGTCATCCGTAGAAAACAG	0.527			NA											24	93					0	0	0.004656	0	0
DUSP26	78986	broad.mit.edu	37	8	33451050	33451050	+	Splice_Site	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:33451050C>A	uc003xjp.2	-	3	769	c.436_splice	c.e3+1	p.G146_splice	DUSP26_uc003xjq.2_Splice_Site_p.G146_splice	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26							Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		TCCCCTCCTACCTCCTGGCTG	0.562			NA											3	33					0.004672	0.00503511	0.004672	1	0
KCNU1	157855	broad.mit.edu	37	8	36767015	36767015	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:36767015C>G	uc010lvw.2	+	21	2380	c.2293C>G	c.(2293-2295)CGA>GGA	p.R765G	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	765	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GAGAGAATGGCGATTTCTCTG	0.378			NA											13	109					0	0	0.001855	0	0
GOT1L1	137362	broad.mit.edu	37	8	37793322	37793322	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:37793322G>C	uc011lbj.1	-	7	929	c.829C>G	c.(829-831)CAG>GAG	p.Q277E		NM_152413	NP_689626	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	277					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			ovary(1)	1	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			CCTTCCAGCTGGGAGAGGACA	0.597			NA											11	41					0	0	0.001368	0	0
ADAM9	8754	broad.mit.edu	37	8	38912024	38912024	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:38912024G>T	uc003xmr.2	+	13	1405	c.1327G>T	c.(1327-1329)GAA>TAA	p.E443*	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA|ADAM9_uc003xms.2_5'Flank	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	443	Extracellular (Potential).|Disintegrin.				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			CCCTTGCTGCGAAGGAAGTAC	0.363			NA											6	52					0.00116845	0.00130265	0.001168	1	0
ANK1	286	broad.mit.edu	37	8	41577265	41577265	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:41577265G>T	uc003xok.2	-	10	1105	c.1021C>A	c.(1021-1023)CCA>ACA	p.P341T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.P341T|ANK1_uc003xoj.2_Missense_Mutation_p.P341T|ANK1_uc003xol.2_Missense_Mutation_p.P341T|ANK1_uc003xom.2_Missense_Mutation_p.P374T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	341	ANK 10.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACGTGGAGTGGGGTCAGGTGG	0.607			NA											20	133					9.57634e-11	1.5458e-10	0.00333	1	0
POTEA	340441	broad.mit.edu	37	8	43211911	43211911	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:43211911G>T	uc003xpz.1	+	12	1413	c.1370G>T	c.(1369-1371)AGC>ATC	p.S457I	POTEA_uc003xqa.1_Missense_Mutation_p.S411I	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	457										ovary(1)	1						GATTCTGCTAGCCTATCAAAA	0.358			NA											9	56					0.000274275	0.000319476	0.004482	1	0
SNTG1	54212	broad.mit.edu	37	8	51621488	51621488	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:51621488C>A	uc010lxy.1	+	18	1605	c.1234C>A	c.(1234-1236)CTC>ATC	p.L412I	SNTG1_uc003xqs.1_Missense_Mutation_p.L412I|SNTG1_uc010lxz.1_Missense_Mutation_p.L412I|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	412					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCTAATGGGACTCACAATTGA	0.358			NA											21	67					1.96292e-10	3.13036e-10	0.010504	1	0
ST18	9705	broad.mit.edu	37	8	53079446	53079446	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:53079446C>T	uc003xqz.2	-	6	1326	c.1170G>A	c.(1168-1170)TCG>TCA	p.S390S	ST18_uc011ldq.1_Silent_p.S37S|ST18_uc011ldr.1_Silent_p.S355S|ST18_uc011lds.1_Silent_p.S295S|ST18_uc003xra.2_Silent_p.S390S|ST18_uc003xrb.2_Silent_p.S390S	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	390	C2HC-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GGGGGCACCCCGAAAGGCTGC	0.562			NA											22	71					0	0	0.005443	0	0
ATP6V1H	51606	broad.mit.edu	37	8	54714394	54714394	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:54714394G>C	uc003xrl.2	-	8	794	c.642C>G	c.(640-642)TAC>TAG	p.Y214*	ATP6V1H_uc003xrk.2_Nonsense_Mutation_p.Y174*|ATP6V1H_uc003xrm.2_Nonsense_Mutation_p.Y214*|ATP6V1H_uc003xrn.2_Nonsense_Mutation_p.Y196*|ATP6V1H_uc011ldv.1_Nonsense_Mutation_p.Y134*|ATP6V1H_uc010lyd.2_Nonsense_Mutation_p.Y150*	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	214					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			AAGCAAAGCGGTACTCATTGA	0.453			NA											7	18					0	0	0.00308	0	0
RP1	6101	broad.mit.edu	37	8	55542122	55542122	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:55542122A>G	uc003xsd.1	+	4	5828	c.5680A>G	c.(5680-5682)AGT>GGT	p.S1894G	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1894					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATTGCCTGGCAGTAATATGAT	0.393	Colon(91;1014 1389 7634 14542 40420)		NA											11	63					0	0	0.001855	0	0
XKR4	114786	broad.mit.edu	37	8	56436481	56436481	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:56436481T>A	uc003xsf.2	+	3	1680	c.1648T>A	c.(1648-1650)TCC>ACC	p.S550T		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	550						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			ACGGTCCATCTCCAACAACCG	0.597			NA											9	33					0	0	0.004482	0	0
TGS1	96764	broad.mit.edu	37	8	56723451	56723451	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:56723451G>A	uc003xsj.3	+	11	2542	c.2155G>A	c.(2155-2157)GAT>AAT	p.D719N	TGS1_uc010lyh.2_Intron	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	719	Sufficient for catalytic activity.	S-adenosyl-L-methionine (By similarity).		D->A: Loss of catalytic activity.	cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GATTGCCATTGATATCGATCC	0.363	Esophageal Squamous(34;275 823 4842 34837 48447)		NA											24	87					0	0	0.004656	0	0
C8orf46	254778	broad.mit.edu	37	8	67408724	67408724	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:67408724G>T	uc003xwg.2	+	2	516	c.123G>T	c.(121-123)AAG>AAT	p.K41N	C8orf46_uc003xwh.2_RNA|C8orf46_uc011let.1_Missense_Mutation_p.K41N	NM_152765	NP_689978	Q8TAG6	CH046_HUMAN	hypothetical protein LOC254778	41										skin(2)	2			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TCTTGACCAAGAATGTAAGGA	0.448			NA											6	45					2.7689e-08	4.10123e-08	0.001984	1	0
TRPA1	8989	broad.mit.edu	37	8	72966087	72966087	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:72966087C>A	uc003xza.2	-	13	1720	c.1545G>T	c.(1543-1545)TGG>TGT	p.W515C		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	515	ANK 13.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GCAAAGCTGTCCAGCCATTGT	0.463			NA											3	10					0.004672	0.00503511	0.004672	1	0
TRPA1	8989	broad.mit.edu	37	8	72967971	72967971	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:72967971G>A	uc003xza.2	-	11	1489	c.1314C>T	c.(1312-1314)TCC>TCT	p.S438S		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	438	ANK 10.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TGGAATGAATGGACACATTAA	0.408			NA											6	30					0	0	0.004482	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75898355	75898355	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:75898355G>T	uc003yan.2	+	2	508	c.133G>T	c.(133-135)GAG>TAG	p.E45*		NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	45						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TGAGGATGGTGAGTGGTGGAT	0.438			NA											11	49					6.40141e-05	7.85211e-05	0.000978	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617295	77617295	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:77617295G>T	uc003yav.2	+	2	1359	c.972G>T	c.(970-972)GGG>GGT	p.G324G	ZFHX4_uc003yat.1_Silent_p.G324G|ZFHX4_uc003yau.1_Silent_p.G324G|ZFHX4_uc003yaw.1_Silent_p.G324G	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	324						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TAATACAGGGGATTGGCAAAG	0.438			NA								HNSCC(33;0.089)			9	50					1.08611e-07	1.558e-07	0.000978	1	0
ZFHX4	79776	broad.mit.edu	37	8	77764421	77764421	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:77764421G>T	uc003yav.2	+	10	5516	c.5129G>T	c.(5128-5130)GGC>GTC	p.G1710V	ZFHX4_uc003yau.1_Missense_Mutation_p.G1755V|ZFHX4_uc003yaw.1_Missense_Mutation_p.G1710V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1710	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAGATTTGGGCTTGCCAGGC	0.507			NA								HNSCC(33;0.089)			6	25					2.0095e-06	2.69165e-06	0.001984	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767836	77767836	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:77767836T>A	uc003yav.2	+	10	8931	c.8544T>A	c.(8542-8544)GAT>GAA	p.D2848E	ZFHX4_uc003yau.1_Missense_Mutation_p.D2893E|ZFHX4_uc003yaw.1_Missense_Mutation_p.D2848E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2848						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGACCCGGATGACAACGCCG	0.493			NA								HNSCC(33;0.089)			10	35					0	0	0.008291	0	0
CA13	377677	broad.mit.edu	37	8	86163132	86163132	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:86163132C>T	uc003ydg.2	+	2	543	c.201C>T	c.(199-201)TTC>TTT	p.F67F	CA13_uc003ydf.1_RNA	NM_198584	NP_940986	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	67					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0						GCCATTCCTTCAATGTTGACT	0.398			NA											26	144					0	0	0.003954	0	0
CDH17	1015	broad.mit.edu	37	8	95201473	95201473	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:95201473A>T	uc003ygh.2	-	3	217	c.92T>A	c.(91-93)CTG>CAG	p.L31Q	CDH17_uc011lgo.1_Missense_Mutation_p.L31Q|CDH17_uc011lgp.1_Missense_Mutation_p.L31Q	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	31	Extracellular (Potential).|Cadherin 1.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CATGGGTTTCAGGGGTCCACT	0.393			NA											14	50					0	0	0.003163	0	0
INTS8	55656	broad.mit.edu	37	8	95862156	95862156	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:95862156G>C	uc003yhb.2	+	12	1470	c.1344G>C	c.(1342-1344)CTG>CTC	p.L448L	INTS8_uc003yha.1_Silent_p.L448L|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Silent_p.L275L	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	448					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					ATGTGTGTCTGGGGTTGGAAG	0.308			NA											10	51					0	0	0.000978	0	0
UQCRB	7381	broad.mit.edu	37	8	97247745	97247745	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:97247745T>C	uc003yhq.3	-	1	118	c.14A>G	c.(13-15)CAG>CGG	p.Q5R	UQCRB_uc011lgt.1_RNA|UQCRB_uc010mbc.2_RNA	NM_006294	NP_006285	P14927	QCR7_HUMAN	ubiquinol-cytochrome c reductase binding	5					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial respiratory chain	ubiquinol-cytochrome-c reductase activity			ovary(1)	1	Breast(36;5.16e-05)					CTTACCGGCCTGCTTACCAGC	0.542			NA											13	44					0	0	0.00245	0	0
TSPYL5	85453	broad.mit.edu	37	8	98288962	98288962	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:98288962C>G	uc003yhy.2	-	1	1215	c.1111G>C	c.(1111-1113)GAA>CAA	p.E371Q		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	371					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					CACAATTCTTCGTTGATTATC	0.468			NA											34	143					0	0	0.00623	0	0
MATN2	4147	broad.mit.edu	37	8	98954084	98954084	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:98954084C>T	uc003yic.2	+	4	1023	c.792C>T	c.(790-792)TGC>TGT	p.C264C	MATN2_uc003yib.1_Silent_p.C264C|MATN2_uc010mbh.1_Silent_p.C264C|MATN2_uc003yid.2_Silent_p.C264C|MATN2_uc003yie.1_Silent_p.C264C|MATN2_uc010mbi.1_Silent_p.C138C	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	264	EGF-like 1.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TCTGCAGGTGCAAACAAGGCT	0.493			NA											3	14					0	0	0.009096	0	0
SNX31	169166	broad.mit.edu	37	8	101589249	101589249	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:101589249G>A	uc003yjr.2	-	13	1376	c.1225C>T	c.(1225-1227)CAG>TAG	p.Q409*	SNX31_uc011lha.1_Nonsense_Mutation_p.Q204*|SNX31_uc011lhb.1_Nonsense_Mutation_p.Q310*	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	409					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TCACAGACCTGGCTTTGTTGA	0.333			NA											23	85					0	0	0.00278	0	0
RIMS2	9699	broad.mit.edu	37	8	104898239	104898239	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:104898239G>C	uc003yls.2	+	2	987	c.746G>C	c.(745-747)CGG>CCG	p.R249P	RIMS2_uc003ylp.2_Missense_Mutation_p.R471P|RIMS2_uc003ylw.2_Missense_Mutation_p.R279P|RIMS2_uc003ylq.2_Missense_Mutation_p.R279P|RIMS2_uc003ylr.2_Missense_Mutation_p.R279P	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	502					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAACAAAACGGGAAAAAATG	0.443			NA								HNSCC(12;0.0054)			5	35					0	0	0.001168	0	0
RIMS2	9699	broad.mit.edu	37	8	105001583	105001583	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:105001583A>G	uc003yls.2	+	15	2553	c.2312A>G	c.(2311-2313)TAT>TGT	p.Y771C	RIMS2_uc003ylp.2_Missense_Mutation_p.Y993C|RIMS2_uc003ylw.2_Missense_Mutation_p.Y785C|RIMS2_uc003ylq.2_Missense_Mutation_p.Y785C|RIMS2_uc003ylr.2_Missense_Mutation_p.Y832C	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1055					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCGGACATTATAATACAATT	0.373			NA								HNSCC(12;0.0054)			16	69					0	0	0.004007	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361010	105361010	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:105361010A>C	uc003ylx.1	+	2	279	c.230A>C	c.(229-231)CAT>CCT	p.H77P		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	77	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTCCAAGCATGCACGATGT	0.537			NA											11	62					0	0	0.000978	0	0
TM7SF4	81501	broad.mit.edu	37	8	105367361	105367361	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:105367361C>G	uc003ylx.1	+	3	1335	c.1286C>G	c.(1285-1287)TCA>TGA	p.S429*		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	429	Cytoplasmic.				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAAAAAAGATCAAAGCAGCCG	0.453			NA											10	43					0	0	0.001368	0	0
DPYS	1807	broad.mit.edu	37	8	105440265	105440265	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:105440265G>T	uc003yly.3	-	6	1164	c.1035C>A	c.(1033-1035)ATC>ATA	p.I345I		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	345					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCCCATTGGGGATCTTGGTAA	0.453			NA											16	65					1.99824e-07	2.83847e-07	0.00499	1	0
ANGPT1	284	broad.mit.edu	37	8	108315513	108315513	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:108315513A>T	uc003ymn.2	-	5	1359	c.891T>A	c.(889-891)AGT>AGA	p.S297R	ANGPT1_uc011lhv.1_Missense_Mutation_p.S97R|ANGPT1_uc003ymo.2_Missense_Mutation_p.S296R|ANGPT1_uc003ymp.3_Missense_Mutation_p.S96R	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	297	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGTAGATTCCACTTTTATTAA	0.323			NA											22	49					0	0	0.010504	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110478983	110478983	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:110478983C>A	uc003yne.2	+	50	8694	c.8590C>A	c.(8590-8592)CTT>ATT	p.L2864I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2864	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGATGTGGTTCTTTCAGACTC	0.378			NA								HNSCC(38;0.096)			5	16					0.000602214	0.000682885	0.000602	1	0
CSMD3	114788	broad.mit.edu	37	8	113353818	113353818	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:113353818C>A	uc003ynu.2	-	42	6699	c.6540G>T	c.(6538-6540)CGG>CGT	p.R2180R	CSMD3_uc003yns.2_Silent_p.R1382R|CSMD3_uc003ynt.2_Silent_p.R2140R|CSMD3_uc011lhx.1_Silent_p.R2076R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2180	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GACCACTAAGCCGGCCAATAA	0.383			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	41					2.23348e-06	2.98893e-06	0.004007	1	0
UTP23	84294	broad.mit.edu	37	8	117783872	117783872	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:117783872G>T	uc003yoc.2	+	3	642	c.541G>T	c.(541-543)GAA>TAA	p.E181*		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	181					rRNA processing	nucleolus					0						TCTCAAAGAGGAACAGGGTTT	0.393			NA											10	45					2.17888e-05	2.75625e-05	0.006214	1	0
ENPP2	5168	broad.mit.edu	37	8	120612922	120612922	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:120612922G>T	uc003yot.1	-	11	1054	c.968C>A	c.(967-969)CCT>CAT	p.P323H	ENPP2_uc003yos.1_Missense_Mutation_p.P323H|ENPP2_uc010mdd.1_Missense_Mutation_p.P323H	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	323					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ACTAACCTCAGGGCCGAAAGG	0.448	Melanoma(20;305 879 2501 4818 31020)		NA											6	42					0.00448238	0.00486678	0.004482	1	0
ZNF572	137209	broad.mit.edu	37	8	125988958	125988958	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:125988958C>T	uc003yrr.2	+	3	603	c.448C>T	c.(448-450)CAC>TAC	p.H150Y		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	150	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTTGCGTACTCACCAGAGGAC	0.413			NA								HNSCC(60;0.17)			9	44					0	0	0.000978	0	0
KCNQ3	3786	broad.mit.edu	37	8	133192464	133192464	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:133192464C>A	uc003ytj.2	-	4	942	c.717G>T	c.(715-717)CGG>CGT	p.R239R	KCNQ3_uc010mdt.2_Silent_p.R239R	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	239	Helical; Voltage-sensor; Name=Segment S4; (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCCGGTCCATCCGCAGCATGC	0.592			NA											19	58					1.45105e-14	2.50621e-14	0.006122	1	0
TG	7038	broad.mit.edu	37	8	133881998	133881999	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:133881998_133881999CC>AG	uc003ytw.2	+	3	242_243	c.201_202CC>AG	c.(199-204)GGCCGC>GGAGGC	p.R68G		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	68	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGAACGACGGCCGCTCCTGCTG	0.649			NA											5	43					0	0	0.004672	0	0
ZFAT	57623	broad.mit.edu	37	8	135613823	135613823	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:135613823G>A	uc003yup.2	-	6	2314	c.2139C>T	c.(2137-2139)ACC>ACT	p.T713T	ZFAT_uc003yun.2_Silent_p.T701T|ZFAT_uc003yuo.2_Silent_p.T701T|ZFAT_uc010meh.2_Silent_p.T701T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.T701T|ZFAT_uc010mej.2_Silent_p.T651T|ZFAT_uc003yur.2_Silent_p.T701T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	713					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TCATGAAAGCGGTGATGCCTG	0.537			NA											22	56					0	0	0.00278	0	0
FAM135B	51059	broad.mit.edu	37	8	139163634	139163634	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:139163634C>A	uc003yuy.2	-	13	3255	c.3084G>T	c.(3082-3084)GTG>GTT	p.V1028V	FAM135B_uc003yux.2_Silent_p.V929V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.V590V|FAM135B_uc003yvb.2_Silent_p.V590V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1028										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCACAACCTCCACAGCCTTCA	0.527			NA								HNSCC(54;0.14)			4	25					1.23904e-05	1.57558e-05	0.000602	1	0
FAM135B	51059	broad.mit.edu	37	8	139255187	139255187	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:139255187C>T	uc003yuy.2	-	7	838	c.667G>A	c.(667-669)GAG>AAG	p.E223K	FAM135B_uc003yux.2_Missense_Mutation_p.E124K|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	223										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCCTTACCTCTGAGGAAGTC	0.463			NA								HNSCC(54;0.14)			5	32					0	0	0.000602	0	0
EIF2C2	27161	broad.mit.edu	37	8	141567304	141567304	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:141567304C>T	uc003yvn.2	-	8	950	c.910G>A	c.(910-912)GTG>ATG	p.V304M	EIF2C2_uc010men.2_Missense_Mutation_p.V227M|EIF2C2_uc010meo.2_Missense_Mutation_p.V304M	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	304	PAZ.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GTGCACTCCACCGTCTGCCCG	0.597			NA											11	54					0	0	0.000978	0	0
PTK2	5747	broad.mit.edu	37	8	141754835	141754835	+	Missense_Mutation	SNP	C	C	A	rs146511319	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:141754835C>A	uc003yvu.2	-	19	1780	c.1550G>T	c.(1549-1551)AGT>ATT	p.S517I	PTK2_uc003yvo.2_Missense_Mutation_p.S145I|PTK2_uc011ljq.1_Missense_Mutation_p.S212I|PTK2_uc003yvp.2_Missense_Mutation_p.S185I|PTK2_uc003yvq.2_Missense_Mutation_p.S43I|PTK2_uc003yvr.2_Missense_Mutation_p.S457I|PTK2_uc003yvs.2_Missense_Mutation_p.S517I|PTK2_uc003yvt.2_Missense_Mutation_p.S539I|PTK2_uc003yvv.2_Missense_Mutation_p.S417I|PTK2_uc011ljr.1_Missense_Mutation_p.S517I	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	517	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TAGATCCAAACTGTATTTCCT	0.348			NA											11	49					0.000978159	0.00109807	0.000978	1	0
PARP10	84875	broad.mit.edu	37	8	145060242	145060242	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:145060242G>C	uc003zal.3	-	2	270	c.162C>G	c.(160-162)CTC>CTG	p.L54L	PARP10_uc003zak.3_5'Flank|PARP10_uc011lku.1_Silent_p.L66L|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.L54L|PARP10_uc010mfn.1_Silent_p.L54L|PARP10_uc010mfo.1_Intron	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	54						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCTGAAGGTGAGGACGCCCC	0.632			NA											8	39					0	0	0.00308	0	0
SPATC1	375686	broad.mit.edu	37	8	145101812	145101812	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:145101812C>A	uc011lkw.1	+	5	1833	c.1731C>A	c.(1729-1731)CTC>CTA	p.L577L	SPATC1_uc011lkx.1_3'UTR	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	577										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCTCCTGCCTCAGCCAGCTGG	0.682			NA											11	42					0.00010058	0.000121128	0.001368	1	0
ZNF250	58500	broad.mit.edu	37	8	146107494	146107494	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:146107494C>T	uc003zeq.3	-	6	1206	c.1089G>A	c.(1087-1089)GGG>GGA	p.G363G	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.G358G|ZNF250_uc010mgg.2_Silent_p.G358G	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		AGGGCTTCTCCCCGGTGTGGA	0.582	NSCLC(16;520 556 24096 40084 43446)		NA											4	17					0	0	0.009096	0	0
DMRT2	10655	broad.mit.edu	37	9	1056563	1056563	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:1056563G>A	uc003zha.2	+	4	1176	c.976G>A	c.(976-978)GTC>ATC	p.V326I	DMRT2_uc003zgx.3_Missense_Mutation_p.V93I|DMRT2_uc010mgz.2_Missense_Mutation_p.V93I|DMRT2_uc003zgy.3_Missense_Mutation_p.V170I|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.V326I	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	326					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TTCTTCTAATGTCAGCGTGGC	0.458			NA											15	42					0	0	0.003163	0	0
CD274	29126	broad.mit.edu	37	9	5465513	5465513	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:5465513C>T	uc003zje.2	+	5	749	c.697C>T	c.(697-699)CAT>TAT	p.H233Y	C9orf46_uc003zjd.2_Intron|CD274_uc011lmb.1_3'UTR|CD274_uc010mhn.2_RNA|CD274_uc003zjf.2_Missense_Mutation_p.H119Y	NM_014143	NP_054862	Q9NZQ7	PD1L1_HUMAN	CD274 molecule precursor	233	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			lung(1)|central_nervous_system(1)	2	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		ACCTCTGGCACATCCTCCAAA	0.388			NA	T	CIITA	PMBL|Hodgkin Lymphona|								7	28					0	0	0.00308	0	0
PTPRD	5789	broad.mit.edu	37	9	8499764	8499764	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:8499764G>T	uc003zkk.2	-	24	2916	c.2205C>A	c.(2203-2205)CCC>CCA	p.P735P	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.P735P|PTPRD_uc003zkm.2_Silent_p.P722P|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	735	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TATTGGGCACGGGTGAGCGCC	0.483			NA								TSP Lung(15;0.13)			17	62					0.006122	0.00658806	0.006122	1	0
PTPRD	5789	broad.mit.edu	37	9	8518231	8518231	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:8518231G>T	uc003zkk.2	-	20	1871	c.1160C>A	c.(1159-1161)TCG>TAG	p.S387*	PTPRD_uc003zkp.2_Nonsense_Mutation_p.S387*|PTPRD_uc003zkq.2_Nonsense_Mutation_p.S387*|PTPRD_uc003zkr.2_Nonsense_Mutation_p.S381*|PTPRD_uc003zks.2_Nonsense_Mutation_p.S377*|PTPRD_uc003zkl.2_Nonsense_Mutation_p.S387*|PTPRD_uc003zkm.2_Nonsense_Mutation_p.S374*|PTPRD_uc003zkn.2_Nonsense_Mutation_p.S387*|PTPRD_uc003zko.2_Nonsense_Mutation_p.S384*	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	387	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTCATAATCCGAGTAGGGACT	0.483			NA								TSP Lung(15;0.13)			19	83					8.10497e-08	1.18008e-07	0.010504	1	0
FREM1	158326	broad.mit.edu	37	9	14859203	14859203	+	Silent	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:14859203T>C	uc003zlm.2	-	4	1199	c.609A>G	c.(607-609)CCA>CCG	p.P203P	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	203					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AAAAACTGTGTGGCTGATCTC	0.507			NA											5	23					0	0	0.000602	0	0
IFNA6	3443	broad.mit.edu	37	9	21350617	21350617	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:21350617G>T	uc011lni.1	-	1	270	c.270C>A	c.(268-270)CTC>CTA	p.L90L		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	90					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TTGTGCTGAAGAGGTTGAAGG	0.483			NA											18	53					1.01871e-10	1.64257e-10	0.008871	1	0
PIGO	84720	broad.mit.edu	37	9	35092239	35092239	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:35092239C>A	uc003zwd.2	-	7	2041	c.1645G>T	c.(1645-1647)GTC>TTC	p.V549F	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.V112F	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	549	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGTAACAGGACGGGCCCAGGG	0.572			NA											12	40					0.00244969	0.00268581	0.00245	1	0
TLN1	7094	broad.mit.edu	37	9	35700302	35700302	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:35700302G>A	uc003zxt.2	-	49	6900	c.6546C>T	c.(6544-6546)ATC>ATT	p.I2182I		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2182					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTGCCATGGTGATACCCTTGG	0.537			NA											11	35					0	0	0.008291	0	0
TLN1	7094	broad.mit.edu	37	9	35700304	35700304	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:35700304T>A	uc003zxt.2	-	49	6898	c.6544A>T	c.(6544-6546)ATC>TTC	p.I2182F		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2182					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCATGGTGATACCCTTGGTC	0.527			NA											10	34					0	0	0.006214	0	0
LOC442421	442421	broad.mit.edu	37	9	66499826	66499826	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:66499826A>T	uc004aee.1	+	1	636	c.636A>T	c.(634-636)ACA>ACT	p.T212T	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						CCTTCTATACAGTTATGCGGC	0.602			NA											3	33					0	0	0.004672	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71555567	71555567	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:71555567G>C	uc004agu.2	+	14	1668	c.1363G>C	c.(1363-1365)GGA>CGA	p.G455R	PIP5K1B_uc011lrq.1_Missense_Mutation_p.G455R|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	455						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CCTAGCCCTGGGATCCCGACA	0.418			NA											16	84					0	0	0.006122	0	0
SMC5	23137	broad.mit.edu	37	9	72967157	72967157	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:72967157C>T	uc004ahr.2	+	25	3333	c.3216C>T	c.(3214-3216)TAC>TAT	p.Y1072Y	SMC5_uc011lry.1_Silent_p.Y217Y	NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	1072					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						TGTTTGTCTACAATGGCCCTC	0.358			NA											15	96					0	0	0.00245	0	0
C9orf85	138241	broad.mit.edu	37	9	74526692	74526692	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:74526692G>A	uc004ain.2	+	1	270	c.42G>A	c.(40-42)CAG>CAA	p.Q14Q	C9orf85_uc004aio.2_RNA|C9orf85_uc010mou.2_RNA|C9orf85_uc010mov.2_RNA|FAM108B1_uc004ail.2_5'Flank|FAM108B1_uc004aim.1_5'Flank	NM_182505	NP_872311	Q96MD7	CI085_HUMAN	hypothetical protein LOC138241	14											0						CCAGACCTCAGAAGCACCAGA	0.512			NA											21	135					0	0	0.004656	0	0
PCSK5	5125	broad.mit.edu	37	9	78710913	78710913	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:78710913C>T	uc004ajz.2	+	8	1540	c.1002C>T	c.(1000-1002)TCC>TCT	p.S334S	PCSK5_uc004ajy.2_Silent_p.S334S|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	334	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						ACACCATCTCCATCAGCAGCA	0.532			NA											4	35					0	0	0.009096	0	0
SLC28A3	64078	broad.mit.edu	37	9	86912137	86912137	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:86912137T>C	uc010mpz.2	-	8	985	c.860A>G	c.(859-861)AAG>AGG	p.K287R	SLC28A3_uc011lsy.1_Missense_Mutation_p.K218R|SLC28A3_uc004anu.1_Missense_Mutation_p.K287R|SLC28A3_uc010mqb.2_Missense_Mutation_p.K218R	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	287	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TGACTTTACCTTAAATGCAAA	0.368	Ovarian(106;425 1539 34835 42413 43572)		NA											6	33					0	0	0.001984	0	0
FAM75C1	441452	broad.mit.edu	37	9	90537715	90537715	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:90537715T>A	uc010mqi.2	+	4	2922	c.2893T>A	c.(2893-2895)TCT>ACT	p.S965T	FAM75C1_uc004apq.3_Missense_Mutation_p.S948T	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GAGGGAGAACTCTAGGAAGCC	0.478			NA											17	50					0	0	0.007413	0	0
FAM75C1	441452	broad.mit.edu	37	9	90537946	90537946	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:90537946C>G	uc010mqi.2	+	4	3153	c.3124C>G	c.(3124-3126)CAA>GAA	p.Q1042E	FAM75C1_uc004apq.3_Missense_Mutation_p.Q1025E	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						TGCTGAGAGCCAAAAAACAGT	0.448			NA											11	38					0	0	0.008291	0	0
WNK2	65268	broad.mit.edu	37	9	95992121	95992121	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:95992121G>T	uc004ati.1	+	2	825	c.825G>T	c.(823-825)ACG>ACT	p.T275T	WNK2_uc011lud.1_Silent_p.T275T|WNK2_uc004atj.2_Silent_p.T275T|WNK2_uc010mrc.1_Silent_p.T275T|WNK2_uc010mrd.1_5'Flank	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	275	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TGCTGGTGACGGAGCTGATGA	0.622			NA											5	10					0.000602214	0.000682885	0.000602	1	0
COL15A1	1306	broad.mit.edu	37	9	101806849	101806849	+	Splice_Site	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:101806849G>A	uc004azb.1	+	25	2781	c.2575_splice	c.e25-1	p.G859_splice		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor						angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CTGAATTGCAGGGCGAGAAGG	0.517			NA											6	52					0	0	0.001984	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433159	104433159	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:104433159T>A	uc004bbp.1	-	3	2136	c.1535A>T	c.(1534-1536)AAG>ATG	p.K512M	GRIN3A_uc004bbq.1_Missense_Mutation_p.K512M	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	512	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CAAGTGTAGCTTACTTGGATG	0.517			NA											17	74					0	0	0.007413	0	0
CYLC2	1539	broad.mit.edu	37	9	105767801	105767801	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:105767801C>A	uc004bbs.2	+	5	958	c.888C>A	c.(886-888)GCC>GCA	p.A296A		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	296	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				agaaggacgccacgaaagatg	0.169			NA											4	12					0.00909568	0.00969496	0.009096	1	0
OR13C5	138799	broad.mit.edu	37	9	107360953	107360953	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:107360953C>A	uc011lvp.1	-	1	742	c.742G>T	c.(742-744)GTG>TTG	p.V248L		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AATGTTATCACCACAGTCAGA	0.423			NA											12	64					9.05144e-12	1.4959e-11	0.001855	1	0
OR13C2	392376	broad.mit.edu	37	9	107367420	107367420	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:107367420C>A	uc011lvq.1	-	1	489	c.489G>T	c.(487-489)GTG>GTT	p.V163V		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCAATTGTACCACAAACACTG	0.443			NA											11	99					2.27111e-07	3.21042e-07	0.001368	1	0
ASTN2	23245	broad.mit.edu	37	9	119737583	119737583	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:119737583C>T	uc004bjs.1	-	10	1894	c.1793G>A	c.(1792-1794)AGC>AAC	p.S598N	ASTN2_uc004bjr.1_Missense_Mutation_p.S594N|ASTN2_uc004bjt.1_Missense_Mutation_p.S547N	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	598	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AAAGCTTTTGCTGACAGGAAG	0.542			NA											5	59					0	0	0.000602	0	0
ASTN2	23245	broad.mit.edu	37	9	119737608	119737608	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:119737608C>A	uc004bjs.1	-	10	1869	c.1768G>T	c.(1768-1770)GGC>TGC	p.G590C	ASTN2_uc004bjr.1_Missense_Mutation_p.G586C|ASTN2_uc004bjt.1_Missense_Mutation_p.G539C	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	590	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGGCCTTGGCCCAAGCTGAAA	0.552			NA											7	48					8.12818e-05	9.82943e-05	0.001984	1	0
CEP110	11064	broad.mit.edu	37	9	123877466	123877466	+	Silent	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:123877466A>T	uc004bkx.1	+	9	1474	c.1443A>T	c.(1441-1443)ATA>ATT	p.I481I	CEP110_uc004bky.1_Silent_p.I85I	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	481	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AAGAAGCTATACAACTAAAAA	0.318			NA											6	41					0	0	0.001168	0	0
PTGS1	5742	broad.mit.edu	37	9	125154597	125154597	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:125154597G>C	uc004bmg.1	+	11	1709	c.1574G>C	c.(1573-1575)GGG>GCG	p.G525A	PTGS1_uc011lys.1_Missense_Mutation_p.G463A|PTGS1_uc010mwb.1_Missense_Mutation_p.G379A|PTGS1_uc004bmf.1_Missense_Mutation_p.G488A|PTGS1_uc004bmh.1_Missense_Mutation_p.G416A|PTGS1_uc011lyt.1_Missense_Mutation_p.G416A	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	525					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATAGAGATTGGGGCTCCCTTT	0.498			NA											19	65					0	0	0.001882	0	0
CRB2	286204	broad.mit.edu	37	9	126136903	126136903	+	Silent	SNP	C	C	A	rs148933240	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:126136903C>A	uc004bnx.1	+	11	3527	c.3435C>A	c.(3433-3435)CTC>CTA	p.L1145L		NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	1145	Extracellular (Potential).|EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TCACCTGCCTCGATGGCAGCC	0.657			NA											10	24					0.00621372	0.00666704	0.006214	1	0
STXBP1	6812	broad.mit.edu	37	9	130432211	130432211	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:130432211A>T	uc004brl.2	+	11	1134	c.937A>T	c.(937-939)AGC>TGC	p.S313C	STXBP1_uc004brk.2_Missense_Mutation_p.S313C	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	313					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						TTTTTCTTCTAGCAAGAGAAT	0.463			NA											28	112					0	0	0.002836	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511549	130511549	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:130511549G>A	uc004bsc.2	-	5	1222	c.1080C>T	c.(1078-1080)GTC>GTT	p.V360V	SH2D3C_uc010mxo.2_Silent_p.V200V|SH2D3C_uc004bry.2_Silent_p.V202V|SH2D3C_uc004brz.3_Silent_p.V6V|SH2D3C_uc011mak.1_Silent_p.V6V|SH2D3C_uc004bsa.2_Silent_p.V203V|SH2D3C_uc004bsb.2_Silent_p.V292V	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	360					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CGGTCATGGTGACGCTGCGCC	0.642			NA											8	34					0	0	0.004482	0	0
SARDH	1757	broad.mit.edu	37	9	136573484	136573484	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:136573484G>T	uc004cep.3	-	11	1529	c.1395C>A	c.(1393-1395)GCC>GCA	p.A465A	SARDH_uc004ceo.2_Silent_p.A465A|SARDH_uc011mdn.1_Silent_p.A465A|SARDH_uc011mdo.1_Silent_p.A297A	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	465					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		AGTAGTTCTTGGCGTAGGACT	0.652			NA											9	53					0.000673444	0.000757755	0.008291	1	0
ABCA2	20	broad.mit.edu	37	9	139905127	139905127	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:139905127C>A	uc011mem.1	-	39	6264	c.6116G>T	c.(6115-6117)CGA>CTA	p.R2039L	ABCA2_uc011mel.1_Missense_Mutation_p.R2040L|ABCA2_uc004ckl.1_Missense_Mutation_p.R1970L|ABCA2_uc004ckm.1_Missense_Mutation_p.R2070L	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	2039					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCGGAGCACTCGCTGCCGCTC	0.632			NA											19	71					2.21704e-12	3.6976e-12	0.00278	1	0
ENTPD2	954	broad.mit.edu	37	9	139944322	139944322	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:139944322C>G	uc004ckw.1	-	7	1205	c.1149G>C	c.(1147-1149)CAG>CAC	p.Q383H	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Missense_Mutation_p.Q383H	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	383	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGGGCTCACCTGAGCCCAGG	0.667			NA											5	23					0	0	0.001168	0	0
CACNA1B	774	broad.mit.edu	37	9	140952664	140952664	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr9:140952664G>A	uc004cog.2	+	28	4415	c.4270G>A	c.(4270-4272)GAC>AAC	p.D1424N	CACNA1B_uc011mfd.1_Missense_Mutation_p.D954N|CACNA1B_uc004coi.2_Missense_Mutation_p.D638N	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1424	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGAGCAGGGGGACAAGGTGAT	0.537			NA											19	80					0	0	0.00278	0	0
ARHGAP6	395	broad.mit.edu	37	X	11187695	11187695	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:11187695C>A	uc004cup.1	-	9	2612	c.1739G>T	c.(1738-1740)CGG>CTG	p.R580L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.R580L|ARHGAP6_uc004cum.1_Missense_Mutation_p.R377L|ARHGAP6_uc004cun.1_Missense_Mutation_p.R400L|ARHGAP6_uc010neb.1_Missense_Mutation_p.R402L|ARHGAP6_uc011mif.1_Missense_Mutation_p.R377L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	580	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CTCCTCAGCCCGGGCTGAACT	0.468			NA											19	51					4.63292e-17	8.2869e-17	0.008871	1	0
AMELX	265	broad.mit.edu	37	X	11316746	11316746	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:11316746C>A	uc004cut.2	+	5	291	c.223C>A	c.(223-225)CCG>ACG	p.P75T	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.P89T|AMELX_uc004cuu.2_Missense_Mutation_p.P59T	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	75					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						ACAGCACCCCCCGACTCACAC	0.602			NA											23	51					3.62473e-10	5.73653e-10	0.001882	1	0
GLRA2	2742	broad.mit.edu	37	X	14627266	14627266	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:14627266G>T	uc010nep.2	+	8	1201	c.869G>T	c.(868-870)GGC>GTC	p.G290V	GLRA2_uc010neq.2_Missense_Mutation_p.G290V|GLRA2_uc004cwe.3_Missense_Mutation_p.G290V|GLRA2_uc011mio.1_Missense_Mutation_p.G201V|GLRA2_uc011mip.1_Missense_Mutation_p.G268V	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	290	Helical; (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	GTCGCACTGGGCATCACCACA	0.463			NA											15	74					1.37285e-15	2.41702e-15	0.004007	1	0
GRPR	2925	broad.mit.edu	37	X	16168633	16168633	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:16168633C>A	uc004cxj.2	+	2	1272	c.619C>A	c.(619-621)CCC>ACC	p.P207T		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	207	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					TGAGCTTCACCCCAAAATCCA	0.463			NA											16	76					3.45872e-05	4.35254e-05	0.004007	1	0
BEND2	139105	broad.mit.edu	37	X	18192213	18192213	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:18192213C>G	uc004cyj.3	-	12	2072	c.1918G>C	c.(1918-1920)GCT>CCT	p.A640P	BEND2_uc010nfb.2_Missense_Mutation_p.A549P	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	640										ovary(3)|kidney(1)|central_nervous_system(1)	5						TCAGGGATAGCATTACTGTTT	0.408			NA											5	40					0	0	0.000602	0	0
KLHL34	257240	broad.mit.edu	37	X	21674824	21674824	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:21674824C>A	uc004czz.1	-	1	1625	c.1083G>T	c.(1081-1083)GTG>GTT	p.V361V		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	361	Kelch 1.									ovary(1)	1						CCGCGGTGCACACGCTGTGCC	0.637			NA											4	17					1.23904e-05	1.57558e-05	0.000602	1	0
PTCHD1	139411	broad.mit.edu	37	X	23412035	23412035	+	Silent	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:23412035G>A	uc004dal.3	+	3	2408	c.2400G>A	c.(2398-2400)CAG>CAA	p.Q800Q		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	800	Helical; (Potential).				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CTATTTTACAGAGTTACCTCT	0.408			NA											10	50					0	0	0.006214	0	0
FAM48B2	170067	broad.mit.edu	37	X	24330701	24330701	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:24330701C>A	uc011mjw.1	-	1	732	c.732G>T	c.(730-732)TGG>TGT	p.W244C		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	244											0						TTACAGAGGGCCACGAATACC	0.512			NA											14	58					4.75885e-15	8.29806e-15	0.00499	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27766004	27766004	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:27766004C>T	uc011mjy.1	+	1	1079	c.992C>T	c.(991-993)CCT>CTT	p.P331L		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						CCTGACTCTCCTTATAAGTTC	0.463			NA											6	14					0	0	0.001168	0	0
MAGEB16	139604	broad.mit.edu	37	X	35821107	35821107	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:35821107T>A	uc010ngt.1	+	2	1073	c.794T>A	c.(793-795)GTG>GAG	p.V265E		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	265	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						TACCAGCAGGTGGCCAACAGT	0.483			NA											4	19					0	0	0.009096	0	0
USP9X	8239	broad.mit.edu	37	X	41000658	41000658	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:41000658G>C	uc004dfb.2	+	9	1768	c.1135G>C	c.(1135-1137)GAG>CAG	p.E379Q	USP9X_uc004dfc.2_Missense_Mutation_p.E379Q	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	379					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TGAGGAGGAAGAGTGGCTCAC	0.363	Ovarian(172;1807 2695 35459 49286)		NA											6	31					0	0	0.001168	0	0
UBA1	7317	broad.mit.edu	37	X	47062972	47062972	+	Silent	SNP	C	C	G			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:47062972C>G	uc004dhj.3	+	14	1603	c.1452C>G	c.(1450-1452)CTC>CTG	p.L484L	UBA1_uc004dhk.3_Silent_p.L484L|INE1_uc004dhl.2_5'Flank	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	484	1-2.|ATP (By similarity).|2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						GTGAGCTGCTCAAGAACTTTG	0.527			NA											10	36					0	0	0.000978	0	0
OTUD5	55593	broad.mit.edu	37	X	48783166	48783166	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:48783166C>A	uc004dlu.2	-	6	1296	c.1235G>T	c.(1234-1236)CGG>CTG	p.R412L	OTUD5_uc004dlt.3_Missense_Mutation_p.R407L|OTUD5_uc004dlv.2_Missense_Mutation_p.R407L|OTUD5_uc011mmp.1_Missense_Mutation_p.R190L	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	412					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						CTCCTGATCCCGCAACCACTG	0.567			NA											4	14					0.00024832	0.000292993	0.009096	1	0
KCND1	3750	broad.mit.edu	37	X	48820029	48820029	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:48820029T>A	uc004dlx.1	-	6	3330	c.1757A>T	c.(1756-1758)GAC>GTC	p.D586V	KCND1_uc004dlw.1_Missense_Mutation_p.D209V	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	586	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						GCAGTTCAGGTCAAGGCTGTC	0.532			NA											6	12					0	0	0.001168	0	0
TSR2	90121	broad.mit.edu	37	X	54467179	54467179	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:54467179G>C	uc004dte.2	+	2	140	c.138G>C	c.(136-138)CTG>CTC	p.L46L	TSR2_uc004dtf.2_Intron	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog	46					rRNA processing		protein binding				0						CCAAGTGGCTGGGGGGTGCAG	0.617			NA											5	18					0	0	0.000602	0	0
ITIH5L	347365	broad.mit.edu	37	X	54783923	54783923	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:54783923G>A	uc004dtj.2	-	8	2614	c.2584C>T	c.(2584-2586)CCA>TCA	p.P862S		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	862	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						ATTTGGTGTGGTGGGGCACTC	0.517			NA											5	23					0	0	0.000602	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963350	73963350	+	Silent	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:73963350G>T	uc004eby.2	-	3	1659	c.1042C>A	c.(1042-1044)CGA>AGA	p.R348R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	348					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTAGACTCTCGCTTGGGGCAG	0.468			NA											14	61					0.00185496	0.00205542	0.001855	1	0
CYLC1	1538	broad.mit.edu	37	X	83128556	83128556	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:83128556T>A	uc004eei.1	+	4	861	c.840T>A	c.(838-840)TAT>TAA	p.Y280*	CYLC1_uc004eeh.1_Nonsense_Mutation_p.Y279*	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	280	1.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						CTTTGAAGTATACAAAGTATA	0.323			NA											7	18					0	0	0.001984	0	0
PABPC5	140886	broad.mit.edu	37	X	90691715	90691715	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:90691715G>C	uc004efg.2	+	2	1579	c.1139G>C	c.(1138-1140)CGC>CCC	p.R380P	PABPC5_uc004eff.1_Missense_Mutation_p.R216P	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	380						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CAGGCCAGGCGCAGGTGCTGA	0.498			NA											5	12					0	0	0.001168	0	0
GLRA4	441509	broad.mit.edu	37	X	102974075	102974075	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:102974075C>A	uc011mse.1	-	7	1264	c.843G>T	c.(841-843)ATG>ATT	p.M281I	GLRA4_uc010nou.2_Missense_Mutation_p.M281I	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	281	Cytoplasmic (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						GGGCAGCATCCATGTTGATCC	0.577			NA											21	81					0.000132079	0.0001588	0.008871	1	0
AMOT	154796	broad.mit.edu	37	X	112058742	112058742	+	Silent	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:112058742C>A	uc004epr.2	-	2	1236	c.1236G>T	c.(1234-1236)CGG>CGT	p.R412R	AMOT_uc004eps.2_Silent_p.R3R|AMOT_uc004ept.1_Silent_p.R412R	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	412					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						ATGGCTGAGCCCGAGGCATAG	0.348			NA											12	44					9.31168e-06	1.20836e-05	0.001855	1	0
KLHL13	90293	broad.mit.edu	37	X	117043381	117043381	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:117043381G>A	uc004eql.2	-	5	1311	c.1249C>T	c.(1249-1251)CGA>TGA	p.R417*	KLHL13_uc004eqk.2_Nonsense_Mutation_p.R366*|KLHL13_uc011mtn.1_Nonsense_Mutation_p.R257*|KLHL13_uc011mto.1_Nonsense_Mutation_p.R411*|KLHL13_uc011mtp.1_Nonsense_Mutation_p.R419*|KLHL13_uc004eqm.2_Nonsense_Mutation_p.R366*|KLHL13_uc011mtq.1_Nonsense_Mutation_p.R401*	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	417	Kelch 2.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						TTATTGTATCGAGGATCAAAT	0.413			NA											16	51					0	0	0.00499	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117960378	117960378	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:117960378G>T	uc004equ.2	+	4	1644	c.1171G>T	c.(1171-1173)GCC>TCC	p.A391S		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						GTCAAGAGTGGCCCCTGGCGA	0.493			NA											6	37					5.9392e-07	8.25141e-07	0.001168	1	0
CT47B1	643311	broad.mit.edu	37	X	120009270	120009270	+	Silent	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:120009270T>A	uc011muc.1	-	1	510	c.255A>T	c.(253-255)TCA>TCT	p.S85S		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	85											0						GCCCGATATCTGAGTCCTCCT	0.617			NA											7	19					0	0	0.00308	0	0
GRIA3	2892	broad.mit.edu	37	X	122460066	122460066	+	Splice_Site	SNP	T	T	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:122460066T>A	uc004etq.3	+	5	989	c.696_splice	c.e5+2	p.Q232_splice	GRIA3_uc004etr.3_Splice_Site_p.Q232_splice|GRIA3_uc004ets.3_Splice_Site|GRIA3_uc011muf.1_Splice_Site_p.Q216_splice	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform						glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TTGGAACAGGTACGTTTGAGA	0.398			NA											5	37					0	0	0.001168	0	0
USP26	83844	broad.mit.edu	37	X	132160979	132160979	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:132160979C>A	uc010nrm.1	-	6	1740	c.1270G>T	c.(1270-1272)GAT>TAT	p.D424Y	USP26_uc011mvf.1_Missense_Mutation_p.D424Y	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	424					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GTGTCAGGATCATCAGCAAAA	0.368	NSCLC(104;342 1621 36940 47097 52632)		NA											17	87					1.15088e-07	1.64282e-07	0.004007	1	0
SAGE1	55511	broad.mit.edu	37	X	134987498	134987498	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:134987498A>C	uc004ezh.2	+	5	568	c.401A>C	c.(400-402)CAG>CCG	p.Q134P	SAGE1_uc010nry.1_Missense_Mutation_p.Q103P|SAGE1_uc011mvv.1_Missense_Mutation_p.Q134P	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	134										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCTCCACCACAGCTTGTTCAT	0.453			NA											10	57					0	0	0.001855	0	0
GPR112	139378	broad.mit.edu	37	X	135429356	135429357	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:135429356_135429357CT>AA	uc004ezu.1	+	6	3782_3783	c.3491_3492CT>AA	c.(3490-3492)ACT>AAA	p.T1164K	GPR112_uc010nsb.1_Missense_Mutation_p.T959K|GPR112_uc010nsc.1_Missense_Mutation_p.T931K	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1164	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GTGATCTCAACTACGTCTACAC	0.47			NA											26	91					0	0	0.004672	0	0
ZIC3	7547	broad.mit.edu	37	X	136649858	136649858	+	Silent	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:136649858G>C	uc004fak.2	+	1	1513	c.1008G>C	c.(1006-1008)GGG>GGC	p.G336G		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	336	C2H2-type 3.|Nuclear localization signal.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CGGGCTGCGGGAAGATCTTTG	0.592			NA											25	78					0	0	0.007291	0	0
F9	2158	broad.mit.edu	37	X	138612957	138612957	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:138612957C>A	uc004fas.1	+	1	63	c.34C>A	c.(34-36)CCA>ACA	p.P12T	F9_uc004fat.1_Missense_Mutation_p.P12T	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	12					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GGCAGAATCACCAGGCCTCAT	0.413			NA											7	57					0.000274275	0.000319476	0.004482	1	0
MAGEC2	51438	broad.mit.edu	37	X	141291417	141291417	+	Silent	SNP	C	C	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:141291417C>T	uc004fbu.1	-	3	705	c.357G>A	c.(355-357)CAG>CAA	p.Q119Q		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	119						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCCCTTTCTGGCTGCTGG	0.418			NA								HNSCC(46;0.14)			4	59					0	0	0.008291	0	0
MAGEA11	4110	broad.mit.edu	37	X	148798282	148798282	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:148798282C>A	uc004fdq.2	+	5	1238	c.1136C>A	c.(1135-1137)CCT>CAT	p.P379H	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.P350H	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	379	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGCACTGATCCTGCATGCTAT	0.557			NA											34	132					2.68265e-12	4.45536e-12	0.002836	1	0
GPR50	9248	broad.mit.edu	37	X	150349713	150349713	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:150349713C>A	uc010ntg.1	+	2	1793	c.1658C>A	c.(1657-1659)CCT>CAT	p.P553H		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	553	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					ATTGCCCACCCTGTGTCTGAC	0.637			NA											13	49					0.00136819	0.00152184	0.001368	1	0
BGN	633	broad.mit.edu	37	X	152772618	152772618	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:152772618G>C	uc004fhr.1	+	7	1056	c.884G>C	c.(883-885)GGG>GCG	p.G295A	BGN_uc004fhq.1_RNA	NM_001711	NP_001702	P21810	PGS1_HUMAN	biglycan preproprotein	295	LRR 10.					proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGCCCTCAGGGCTCCCAGAC	0.637			NA											3	10					0	0	0.004672	0	0
L1CAM	3897	broad.mit.edu	37	X	153129776	153129777	+	Splice_Site	DNP	CC	CC	AT			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:153129776_153129777CC>AT	uc004fjb.2	-	24	3430	c.3322_splice	c.e24+1	p.G1108_splice	L1CAM_uc004fjc.2_Splice_Site_p.G1108_splice|L1CAM_uc010nuo.2_Splice_Site_p.G1103_splice	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor						axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGCGCCTCACCTGTGCCATTG	0.594			NA											21	91					0	0	0.004672	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12942121	12942121	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:12942121delC	uc001aun.2	-	3	500	c.429delG	c.(427-429)ATGfs	p.M143fs		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	143										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCGTCCTCTCATCCTTGGAC	0.507			NA											54	213	---	---	---	---	NA	NA	NA	NA	NA
EIF2C1	26523	broad.mit.edu	37	1	36380996	36380996	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:36380996delG	uc001bzl.2	+	15	2094	c.1881delG	c.(1879-1881)GTGfs	p.V627fs	EIF2C1_uc001bzk.2_Frame_Shift_Del_p.V552fs|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	627	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGCTACTGTGCGGGTACAGC	0.527			NA											11	61	---	---	---	---	NA	NA	NA	NA	NA
PYHIN1	149628	broad.mit.edu	37	1	158908283	158908284	+	Frame_Shift_Ins	INS	-	-	A	rs138593148		TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:158908283_158908284insA	uc001ftb.2	+	3	607_608	c.362_363insA	c.(361-363)CCAfs	p.P121fs	PYHIN1_uc001fta.3_Frame_Shift_Ins_p.P121fs|PYHIN1_uc001ftc.2_Frame_Shift_Ins_p.P112fs|PYHIN1_uc001ftd.2_Frame_Shift_Ins_p.P121fs|PYHIN1_uc001fte.2_Frame_Shift_Ins_p.P112fs	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	121					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					GCATGCACCCCAAGCAACCGTC	0.455			NA											8	73	---	---	---	---	NA	NA	NA	NA	NA
TMEM63A	9725	broad.mit.edu	37	1	226034840	226034842	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	CTG	CTG	-	-	CTG	CTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:226034840_226034842delCTG	uc001hpm.1	-	24	2573_2575	c.2323_2325delCAG	c.(2323-2325)CAGdel	p.Q775del		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	775						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					CACCATAGGTCTGCTGCTGCTGC	0.626			NA											7	119	---	---	---	---	NA	NA	NA	NA	NA
OR13G1	441933	broad.mit.edu	37	1	247836003	247836004	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr1:247836003_247836004insT	uc001idi.1	-	1	340_341	c.340_341insA	c.(340-342)ACCfs	p.T114fs		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATAGGCCATGGTGGTGAAGAGA	0.465			NA											13	37	---	---	---	---	NA	NA	NA	NA	NA
CUBN	8029	broad.mit.edu	37	10	16941090	16941090	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:16941090delC	uc001ioo.2	-	54	8555	c.8503delG	c.(8503-8505)GCCfs	p.A2835fs	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Frame_Shift_Del_p.A191fs	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2835	CUB 21.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGAGTAATGGCCGTCCAGGAA	0.433			NA											13	86	---	---	---	---	NA	NA	NA	NA	NA
CTNNA3	29119	broad.mit.edu	37	10	68535271	68535271	+	Frame_Shift_Del	DEL	T	T	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr10:68535271delT	uc009xpn.1	-	8	1182	c.1059delA	c.(1057-1059)AAAfs	p.K353fs	CTNNA3_uc001jmw.2_Frame_Shift_Del_p.K353fs|CTNNA3_uc001jmx.3_Frame_Shift_Del_p.K353fs	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	353	Potential.				cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TACTCCTTTCTTTTTTTCCAG	0.358			NA											20	134	---	---	---	---	NA	NA	NA	NA	NA
OR51B4	79339	broad.mit.edu	37	11	5322666	5322666	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:5322666delG	uc010qza.1	-	1	511	c.511delC	c.(511-513)CTCfs	p.L171fs	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGTGCAAGAGGGCACGGGAA	0.413			NA											10	48	---	---	---	---	NA	NA	NA	NA	NA
PITPNM1	9600	broad.mit.edu	37	11	67269818	67269818	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:67269818delC	uc001olx.2	-	3	549	c.360delG	c.(358-360)GGGfs	p.G120fs	PITPNM1_uc001oly.2_Frame_Shift_Del_p.G120fs|PITPNM1_uc001olz.2_Frame_Shift_Del_p.G120fs	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	120					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TTGGCTGCTGCCCCCCATCAG	0.607	GBM(28;144 709 4607 5525)		NA											18	65	---	---	---	---	NA	NA	NA	NA	NA
BIRC3	330	broad.mit.edu	37	11	102201833	102201838	+	In_Frame_Del	DEL	AAAACA	AAAACA	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	AAAACA	AAAACA	-	-	AAAACA	AAAACA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr11:102201833_102201838delAAAACA	uc001pgx.2	+	7	1407_1412	c.1185_1190delAAAACA	c.(1183-1191)GTAAAACAG>GTG	p.KQ396del		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	396_397					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		GAAGCCTGGTAAAACAGACAGTTCAG	0.393			NA	T	MALT1	MALT								8	62	---	---	---	---	NA	NA	NA	NA	NA
TMTC1	83857	broad.mit.edu	37	12	29673641	29673641	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:29673641delC	uc001rjb.2	-	12	1948	c.1474delG	c.(1474-1476)GAAfs	p.E492fs	TMTC1_uc001riz.2_Frame_Shift_Del_p.E249fs|TMTC1_uc001rja.2_Frame_Shift_Del_p.E336fs|TMTC1_uc001riy.2_5'Flank	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	600	TPR 4.					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TCTTCAGCTTCTTTAAACCGC	0.328			NA											10	70	---	---	---	---	NA	NA	NA	NA	NA
C12orf51	283450	broad.mit.edu	37	12	112622024	112622024	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:112622024delG	uc009zwc.2	-	54	9498	c.9480delC	c.(9478-9480)GCCfs	p.A3160fs		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TGGGGCGGGCGGCGAGGGGCT	0.532			NA											18	146	---	---	---	---	NA	NA	NA	NA	NA
FBXO21	23014	broad.mit.edu	37	12	117583913	117583914	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr12:117583913_117583914insT	uc001twk.2	-	12	1904_1905	c.1865_1866insA	c.(1864-1866)AAGfs	p.K622fs	FBXO21_uc001twj.2_Frame_Shift_Ins_p.K615fs|FBXO21_uc009zwq.2_Frame_Shift_Ins_p.K555fs	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	622					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TGTTCTCTTTCTTTGCACTGTA	0.465	GBM(168;452 2038 13535 17701 43680)		NA											10	61	---	---	---	---	NA	NA	NA	NA	NA
GPR139	124274	broad.mit.edu	37	16	20043388	20043389	+	Frame_Shift_Ins	INS	-	-	G	rs140063049	byFrequency	TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:20043388_20043389insG	uc002dgu.1	-	2	892_893	c.730_731insC	c.(730-732)CGCfs	p.R244fs	GPR139_uc010vaw.1_Frame_Shift_Ins_p.R151fs	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	244	Helical; Name=6; (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CATGATGATGCGGGGGGCCCAA	0.545			NA											7	55	---	---	---	---	NA	NA	NA	NA	NA
LOC100132247	100132247	broad.mit.edu	37	16	22545922	22545922	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:22545922delC	uc010bxg.2	+	9	1800	c.1618delC	c.(1618-1620)CCGfs	p.P540fs	LOC100132247_uc010vbv.1_Frame_Shift_Del_p.P540fs|LOC100132247_uc010vbw.1_Intron|LOC100132247_uc010bxi.2_Frame_Shift_Del_p.P521fs|LOC100132247_uc010bxk.2_Frame_Shift_Del_p.P357fs|uc010vbx.1_5'Flank	NM_001135865	NP_001129337	A8MRT5	K220L_HUMAN	hypothetical protein LOC100132247	540	Pro-rich.					integral to membrane					0						TCTGCGGGGGCCGCTTCCACC	0.552			NA											7	129	---	---	---	---	NA	NA	NA	NA	NA
PRKCB	5579	broad.mit.edu	37	16	24192147	24192147	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:24192147delG	uc002dmd.2	+	13	1628	c.1431delG	c.(1429-1431)GAGfs	p.E477fs	PRKCB_uc002dme.2_Frame_Shift_Del_p.E477fs	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	477	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TCGATTCTGAGGGACACATCA	0.453			NA											16	115	---	---	---	---	NA	NA	NA	NA	NA
ZC3H18	124245	broad.mit.edu	37	16	88694450	88694451	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr16:88694450_88694451insA	uc002fky.2	+	15	2592_2593	c.2392_2393insA	c.(2392-2394)CAGfs	p.Q798fs	ZC3H18_uc010voz.1_Frame_Shift_Ins_p.Q822fs|ZC3H18_uc010chw.2_Intron|ZC3H18_uc002fkz.2_Frame_Shift_Ins_p.Q68fs	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	798						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTCGACACCCCAGCAGGCACCC	0.584	Ovarian(121;375 2276 20373 38669)		NA											20	120	---	---	---	---	NA	NA	NA	NA	NA
MED1	5469	broad.mit.edu	37	17	37575999	37575999	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:37575999delC	uc002hrv.3	-	14	1480	c.1268delG	c.(1267-1269)AGCfs	p.S423fs	MED1_uc010wee.1_Frame_Shift_Del_p.S251fs|MED1_uc002hru.2_Frame_Shift_Del_p.S423fs	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	423	Interaction with ESR1.|Interaction with THRA.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTTGACACAGCTTCCAATGAG	0.388	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			22	68	---	---	---	---	NA	NA	NA	NA	NA
NXPH3	11248	broad.mit.edu	37	17	47656602	47656602	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:47656602delC	uc002ipa.2	+	2	983	c.699delC	c.(697-699)GTCfs	p.V233fs	NXPH3_uc010wlw.1_Frame_Shift_Del_p.V233fs	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	233	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					ATCGGCTGGTCCAGAAGGTGT	0.602			NA											8	62	---	---	---	---	NA	NA	NA	NA	NA
ANKFN1	162282	broad.mit.edu	37	17	54517785	54517785	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:54517785delG	uc002iun.1	+	8	1052	c.1017delG	c.(1015-1017)ATGfs	p.M339fs		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	339	Fibronectin type-III.									large_intestine(1)|ovary(1)	2						GACTTACAATGGTAAATGTCC	0.428			NA											13	53	---	---	---	---	NA	NA	NA	NA	NA
TTYH2	94015	broad.mit.edu	37	17	72249262	72249263	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr17:72249262_72249263insAA	uc002jkc.2	+	12	1333_1334	c.1302_1303insAA	c.(1300-1305)AACCCCfs	p.N434fs	TTYH2_uc010wqw.1_Frame_Shift_Ins_p.N413fs|TTYH2_uc002jkd.2_Frame_Shift_Ins_p.N113fs	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	434_435	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						ACCCCTTTAACCCCCAAGCCTG	0.584			NA											16	114	---	---	---	---	NA	NA	NA	NA	NA
DOT1L	84444	broad.mit.edu	37	19	2222371	2222371	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:2222371delC	uc002lvb.3	+	24	3239	c.3203delC	c.(3202-3204)ACCfs	p.T1068fs	DOT1L_uc002lvc.1_Frame_Shift_Del_p.T362fs|DOT1L_uc002lve.1_3'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1068						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCCCCTGACCGCCAGCGCC	0.672			NA											7	16	---	---	---	---	NA	NA	NA	NA	NA
NKPD1	284353	broad.mit.edu	37	19	45655751	45655752	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:45655751_45655752insT	uc010xxi.1	-	4	1943_1944	c.1943_1944insA	c.(1942-1944)CCCfs	p.P648fs		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		GGCGCGGCGTGGGGCCCCCAAA	0.693			NA											8	6	---	---	---	---	NA	NA	NA	NA	NA
ZNF813	126017	broad.mit.edu	37	19	53994115	53994116	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:53994115_53994116delTG	uc002qbu.2	+	4	757_758	c.629_630delTG	c.(628-630)ATGfs	p.M210fs	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		GAGGTACACATGAGAGAAAAGT	0.347			NA											46	62	---	---	---	---	NA	NA	NA	NA	NA
LILRA1	11024	broad.mit.edu	37	19	55106837	55106837	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr19:55106837delC	uc002qgh.1	+	5	813	c.631delC	c.(631-633)CCCfs	p.P211fs	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Frame_Shift_Del_p.P211fs	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	211	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GTGGTCTCTACCCAGTGATCT	0.597			NA											62	67	---	---	---	---	NA	NA	NA	NA	NA
DHRS9	10170	broad.mit.edu	37	2	169939978	169939978	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:169939978delG	uc002uep.2	+	6	1957	c.453delG	c.(451-453)TTGfs	p.L151fs	DHRS9_uc002ueq.2_Frame_Shift_Del_p.L151fs|DHRS9_uc010zdc.1_Frame_Shift_Del_p.L211fs|DHRS9_uc010zdd.1_Frame_Shift_Del_p.L151fs|DHRS9_uc010zde.1_Frame_Shift_Del_p.L151fs	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	151					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						TGCTTCCTTTGGTCAAGAAAG	0.473			NA											14	94	---	---	---	---	NA	NA	NA	NA	NA
LRP2	4036	broad.mit.edu	37	2	170058337	170058337	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:170058337delC	uc002ues.2	-	44	8466	c.8253delG	c.(8251-8253)GGGfs	p.G2751fs		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2751	Extracellular (Potential).|LDL-receptor class A 17.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGACACATCGCCCATTGGCAC	0.478			NA											10	57	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179605401	179605401	+	Frame_Shift_Del	DEL	T	T	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179605401delT	uc010zfh.1	-	46	12270	c.12046delA	c.(12046-12048)AGTfs	p.S4016fs	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Frame_Shift_Del_p.S3949fs|TTN_uc010zfj.1_Frame_Shift_Del_p.S3824fs|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACATGGCACTTGGGAAGATT	0.403			NA											19	73	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179610640	179610640	+	Frame_Shift_Del	DEL	A	A	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:179610640delA	uc002unb.2	-	46	16711	c.16487delT	c.(16486-16488)TTAfs	p.L5496fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGCTCTTTAAGACCAATTC	0.398			NA											16	96	---	---	---	---	NA	NA	NA	NA	NA
SPEG	10290	broad.mit.edu	37	2	220344787	220344788	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr2:220344787_220344788insC	uc010fwg.2	+	25	5267_5268	c.5267_5268insC	c.(5266-5268)TGCfs	p.C1756fs		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1756	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCCAGTACTGCCAGTATGGCA	0.599			NA											12	63	---	---	---	---	NA	NA	NA	NA	NA
FASTKD5	60493	broad.mit.edu	37	20	3129210	3129210	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:3129210delC	uc002whz.2	-	2	818	c.507delG	c.(505-507)AAGfs	p.K169fs	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	169					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						AAGAGCTCAGCTTACACAAAT	0.443			NA											10	36	---	---	---	---	NA	NA	NA	NA	NA
CST11	140880	broad.mit.edu	37	20	23433334	23433334	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:23433334delC	uc002wtf.1	-	1	149	c.115delG	c.(115-117)GCAfs	p.A39fs	CST11_uc002wtg.1_Frame_Shift_Del_p.A39fs	NM_130794	NP_570612	Q9H112	CST11_HUMAN	cystatin 11 isoform 1 precursor	39					defense response to bacterium	cytoplasm|nucleus	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					TTTTCTACTGCCATCACTTCA	0.488			NA											28	83	---	---	---	---	NA	NA	NA	NA	NA
SAMHD1	25939	broad.mit.edu	37	20	35539642	35539642	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr20:35539642delC	uc002xgh.1	-	11	1379	c.1249delG	c.(1249-1251)GAAfs	p.E417fs		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	417					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				GTATAGGCTTCCATGTCGTCA	0.383			NA											23	83	---	---	---	---	NA	NA	NA	NA	NA
P2RX6	9127	broad.mit.edu	37	22	21369622	21369622	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr22:21369622delG	uc010gsu.1	+	1	159	c.159delG	c.(157-159)GTGfs	p.V53fs	MGC16703_uc002zty.3_5'Flank|MGC16703_uc002ztx.3_5'Flank|MGC16703_uc010gss.1_5'Flank|P2RX6_uc002ztz.2_Intron|P2RX6_uc010gst.1_Frame_Shift_Del_p.V43fs|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	53	Helical; Name=1; (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TGGTCTATGTGGTAGGGTAAG	0.592			NA											7	159	---	---	---	---	NA	NA	NA	NA	NA
GABRA4	2557	broad.mit.edu	37	4	46981053	46981054	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:46981053_46981054insA	uc003gxg.2	-	3	406_407	c.267_268insT	c.(265-270)GTTGAAfs	p.V89fs		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	89_90	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCTACCATTTCAACATCAGAAA	0.322	Ovarian(6;283 369 8234 12290 33402)		NA											16	57	---	---	---	---	NA	NA	NA	NA	NA
KIAA1211	57482	broad.mit.edu	37	4	57173812	57173812	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:57173812delC	uc003hbk.2	+	5	623	c.232delC	c.(232-234)CCCfs	p.P78fs	KIAA1211_uc010iha.2_Frame_Shift_Del_p.P71fs|KIAA1211_uc011bzz.1_5'Flank|KIAA1211_uc003hbl.2_5'Flank|KIAA1211_uc003hbm.1_5'Flank	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	78										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CCTGACCAGTCCCATGGAAAT	0.498			NA											8	54	---	---	---	---	NA	NA	NA	NA	NA
EPHA5	2044	broad.mit.edu	37	4	66356246	66356246	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr4:66356246delC	uc003hcy.2	-	5	1444	c.1251delG	c.(1249-1251)CGGfs	p.R417fs	EPHA5_uc003hcx.2_Frame_Shift_Del_p.R348fs|EPHA5_uc003hcz.2_Frame_Shift_Del_p.R417fs|EPHA5_uc011cah.1_Frame_Shift_Del_p.R417fs|EPHA5_uc011cai.1_Frame_Shift_Del_p.R417fs|EPHA5_uc003hda.2_Frame_Shift_Del_p.R417fs	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	417	Fibronectin type-III 1.|Extracellular (Potential).		R -> Q (in a lung adenocarcinoma sample; somatic mutation).		cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.R417Q(1)		lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GGCCGCTTTGCCGGGGAAGGT	0.493			NA								TSP Lung(17;0.13)			18	50	---	---	---	---	NA	NA	NA	NA	NA
RASA1	5921	broad.mit.edu	37	5	86648978	86648978	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:86648978delG	uc003kiw.2	+	9	1376	c.1258delG	c.(1258-1260)GGGfs	p.G420fs	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Frame_Shift_Del_p.G243fs|RASA1_uc011ctv.1_Frame_Shift_Del_p.G253fs|RASA1_uc011ctw.1_Frame_Shift_Del_p.G254fs|RASA1_uc010jaw.2_Frame_Shift_Del_p.G242fs	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	420	SH2 2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TAACAGCATTGGGGACATCAT	0.303			NA											11	33	---	---	---	---	NA	NA	NA	NA	NA
PCDHAC2	56134	broad.mit.edu	37	5	140348144	140348144	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:140348144delC	uc003lii.2	+	1	2033	c.1793delC	c.(1792-1794)GCCfs	p.A598fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Frame_Shift_Del_p.A598fs	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	598	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCGAACTGCCCCTGCTGGC	0.522	Melanoma(190;638 2083 3390 11909 52360)		NA											16	24	---	---	---	---	NA	NA	NA	NA	NA
C5orf40	408263	broad.mit.edu	37	5	156769909	156769910	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr5:156769909_156769910insC	uc003lwu.2	-	2	823_824	c.635_636insG	c.(634-636)GGTfs	p.G212fs	CYFIP2_uc003lwq.2_Intron|CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Intron|CYFIP2_uc003lws.2_Intron|CYFIP2_uc003lwt.2_Intron|CYFIP2_uc011ddp.1_Intron	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	hypothetical protein LOC408263	212						integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGGTCACCACCCCCCCTCTG	0.584			NA									OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	51	---	---	---	---	NA	NA	NA	NA	NA
ZNF292	23036	broad.mit.edu	37	6	87964645	87964646	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr6:87964645_87964646insA	uc003plm.3	+	8	1339_1340	c.1298_1299insA	c.(1297-1299)TTAfs	p.L433fs		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TGTGAGCTGTTACTTGTATTGA	0.386			NA											11	25	---	---	---	---	NA	NA	NA	NA	NA
VSTM2A	222008	broad.mit.edu	37	7	54617582	54617582	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:54617582delG	uc010kzf.2	+	4	758	c.353delG	c.(352-354)AGGfs	p.R118fs	VSTM2A_uc010kze.2_Frame_Shift_Del_p.R118fs|VSTM2A_uc003tqc.3_Frame_Shift_Del_p.R118fs	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	118	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			TCCAAAGTGAGGAAAAAGGAT	0.433			NA											7	21	---	---	---	---	NA	NA	NA	NA	NA
CACNA2D1	781	broad.mit.edu	37	7	81746367	81746368	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	AT	AT	-	-	AT	AT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr7:81746367_81746368delAT	uc003uhr.1	-	6	774_775	c.518_519delAT	c.(517-519)TATfs	p.Y173fs		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	173	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TACAGCCCTCATAGATGTCAGT	0.411			NA											13	135	---	---	---	---	NA	NA	NA	NA	NA
RP1L1	94137	broad.mit.edu	37	8	10469147	10469147	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:10469147delG	uc003wtc.2	-	4	2690	c.2461delC	c.(2461-2463)CACfs	p.H821fs		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	821					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGGCTTCGGTGGGGGCCCACC	0.701			NA											7	28	---	---	---	---	NA	NA	NA	NA	NA
MMP16	4325	broad.mit.edu	37	8	89128827	89128827	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:89128827delC	uc003yeb.3	-	6	1274	c.992delG	c.(991-993)GGCfs	p.G331fs	MMP16_uc003yec.2_Frame_Shift_Del_p.G331fs	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	331	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						GGAGGGTCTGCCGGTTGGAGG	0.532			NA											21	66	---	---	---	---	NA	NA	NA	NA	NA
FER1L6	654463	broad.mit.edu	37	8	125047670	125047670	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chr8:125047670delC	uc003yqw.2	+	19	2645	c.2439delC	c.(2437-2439)CACfs	p.H813fs	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	813	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCACCAATCACCCCCCATCTA	0.542			NA											7	38	---	---	---	---	NA	NA	NA	NA	NA
PABPC5	140886	broad.mit.edu	37	X	90691552	90691552	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5781-01A-01D-1625-08	TCGA-64-5781-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb9cfb49-99cf-4f49-8f3d-e25e762eb3ce	3bd98c92-eaf2-4469-bc17-509bb7cd2197	g.chrX:90691552delG	uc004efg.2	+	2	1416	c.976delG	c.(976-978)GGGfs	p.G326fs	PABPC5_uc004eff.1_Frame_Shift_Del_p.G162fs	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	326	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TTCTTCCTTTGGGTCAATTAG	0.438			NA											7	53	---	---	---	---	NA	NA	NA	NA	NA
