Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRAMEF12	390999	broad.mit.edu	37	1	12835749	12835749	+	Silent	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:12835749T>C	uc001aui.2	+	2	378	c.351T>C	c.(349-351)TCT>TCC	p.S117S		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	117										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCATATGGTCTGGAGCTTCTG	0.542			NA											15	174					0	0	0.00499	0	0
CCDC24	149473	broad.mit.edu	37	1	44461327	44461327	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:44461327G>A	uc001clj.2	+	7	778	c.607G>A	c.(607-609)GAG>AAG	p.E203K	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|CCDC24_uc001clk.2_Missense_Mutation_p.E158K|CCDC24_uc009vxc.2_Missense_Mutation_p.E167K	NM_152499	NP_689712	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	203	Potential.										0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GGCAGCCCTGGAGCCCACCCT	0.647			NA											5	6					0	0	0.000602	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47548004	47548004	+	Splice_Site	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:47548004A>C	uc001cqu.1	+	4	368	c.365_splice	c.e4-2	p.G122_splice		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1							endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						TCATTTCATAAGGTCGAGGAC	0.448			NA											10	35					0	0	0.000978	0	0
TTLL7	79739	broad.mit.edu	37	1	84415658	84415658	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:84415658T>C	uc001djc.2	-	4	565	c.169A>G	c.(169-171)ATA>GTA	p.I57V	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	57	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ATTTCATCTATTACTAAACGA	0.308			NA											12	18					0	0	0.000978	0	0
HRNR	388697	broad.mit.edu	37	1	152187828	152187828	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:152187828T>C	uc001ezt.1	-	3	6353	c.6277A>G	c.(6277-6279)AGC>GGC	p.S2093G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2093	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCACTGCTGGAAGACCGA	0.617			NA											14	44					0	0	0.008871	0	0
CD5L	922	broad.mit.edu	37	1	157805885	157805885	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:157805885A>C	uc001frk.3	-	3	259	c.116T>G	c.(115-117)GTG>GGG	p.V39G		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	39	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTTCTGTTCCACCTCCACCCG	0.637			NA											10	104					0	0	0.002299	0	0
ATP1A4	480	broad.mit.edu	37	1	160124926	160124926	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:160124926T>G	uc001fve.3	+	3	778	c.299T>G	c.(298-300)TTC>TGC	p.F100C	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	100	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGGGTCAAATTCTGTAAGCAA	0.522			NA											19	85					0	0	0.008871	0	0
NCSTN	23385	broad.mit.edu	37	1	160318908	160318908	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:160318908A>G	uc001fvx.2	+	3	434	c.310A>G	c.(310-312)ACC>GCC	p.T104A	NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.T84A|NCSTN_uc010pjf.1_Missense_Mutation_p.T104A|NCSTN_uc001fvz.2_5'Flank|NCSTN_uc010pjg.1_5'Flank	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	104	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAAGCATTTTACCAGGTAAGA	0.473			NA											11	53					0	0	0.000978	0	0
C1orf112	55732	broad.mit.edu	37	1	169816858	169816858	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:169816858A>G	uc001ggp.2	+	21	2282	c.1972A>G	c.(1972-1974)AAA>GAA	p.K658E	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggq.2_Missense_Mutation_p.K658E|C1orf112_uc009wvt.2_Missense_Mutation_p.K335E|C1orf112_uc009wvu.1_Missense_Mutation_p.K534E|C1orf112_uc001ggr.2_Missense_Mutation_p.K523E|C1orf112_uc010plv.1_Missense_Mutation_p.K600E	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	658											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTCGCTACTTAAATTAGAGCT	0.353			NA											13	284					0	0	0.00245	0	0
KIFAP3	22920	broad.mit.edu	37	1	170003573	170003573	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:170003573C>T	uc001ggv.2	-	7	953	c.682G>A	c.(682-684)GAT>AAT	p.D228N	KIFAP3_uc010ply.1_Missense_Mutation_p.D150N|KIFAP3_uc001ggw.1_Missense_Mutation_p.D184N	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	228					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AACTCATGATCAATAATATTC	0.303			NA											19	82					0	0	0.008871	0	0
CR2	1380	broad.mit.edu	37	1	207642160	207642160	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:207642160C>T	uc001hfw.2	+	4	744	c.650C>T	c.(649-651)TCT>TTT	p.S217F	CR2_uc001hfv.2_Missense_Mutation_p.S217F|CR2_uc009xch.2_Missense_Mutation_p.S217F|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	217	Sushi 4.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CGCTGTAAATCTCTAGGACGA	0.408			NA											26	101					0	0	0.004656	0	0
CABC1	56997	broad.mit.edu	37	1	227169734	227169734	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:227169734A>C	uc001hqm.1	+	11	4156	c.737A>C	c.(736-738)AAG>ACG	p.K246T	CABC1_uc001hqn.1_Missense_Mutation_p.K246T|CABC1_uc009xeq.1_Missense_Mutation_p.K194T|CABC1_uc010pvq.1_5'UTR|CABC1_uc010pvr.1_5'UTR|CABC1_uc001hqo.1_5'UTR|CABC1_uc009xer.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	246					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				ACAGGGAAGAAGGCCGTGCTG	0.652			NA											5	49					0	0	0.001168	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227223259	227223259	+	Silent	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:227223259A>C	uc001hqr.2	-	24	4087	c.3144T>G	c.(3142-3144)ACT>ACG	p.T1048T	CDC42BPA_uc001hqq.2_Silent_p.T347T|CDC42BPA_uc001hqs.2_Silent_p.T967T|CDC42BPA_uc009xes.2_Silent_p.T1020T|CDC42BPA_uc010pvs.1_Silent_p.T1028T|CDC42BPA_uc001hqp.2_Silent_p.T204T|CDC42BPA_uc001hqt.2_5'Flank|CDC42BPA_uc001hqu.1_Silent_p.T255T	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1061	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				GAACTGGACAAGTGGTTGGAG	0.378			NA											6	127					0	0	0.00308	0	0
HEATR1	55127	broad.mit.edu	37	1	236737633	236737633	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:236737633T>C	uc001hyd.1	-	24	3453	c.3328A>G	c.(3328-3330)ATT>GTT	p.I1110V	HEATR1_uc009xgh.1_Missense_Mutation_p.I272V	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1110					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GGTTTTGTAATCTAGAGGGGG	0.318			NA											80	56					0	0	0.00361	0	0
ZMYND11	10771	broad.mit.edu	37	10	255922	255922	+	Silent	SNP	A	A	T	rs138135446	byFrequency	TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr10:255922A>T	uc010pzt.1	+	3	638	c.210A>T	c.(208-210)ACA>ACT	p.T70T	ZMYND11_uc001ifk.2_Silent_p.T70T|ZMYND11_uc010pzu.1_Silent_p.T70T|ZMYND11_uc010pzv.1_Silent_p.T70T|ZMYND11_uc010pzw.1_Silent_p.T70T|ZMYND11_uc001ifm.2_Silent_p.T70T|ZMYND11_uc010pzx.1_Silent_p.T70T|ZMYND11_uc001ifn.2_Silent_p.T70T|ZMYND11_uc009xhg.2_Silent_p.T53T|ZMYND11_uc009xhh.2_Silent_p.T24T|ZMYND11_uc010pzy.1_Silent_p.T24T	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	30					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AAACTCTAACAGTGGGCTGCA	0.418			NA											45	97					0	0	0.003214	0	0
SVIL	6840	broad.mit.edu	37	10	29821735	29821735	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr10:29821735T>G	uc001iut.1	-	8	2314	c.1561A>C	c.(1561-1563)AGT>CGT	p.S521R	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.S521R	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	521					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ACAGGCTCACTTTGAATGTAG	0.557			NA											4	127					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	10	31001490	31001490	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr10:31001490A>C	uc010qdx.1	+	9	1474	c.932A>C	c.(931-933)AAA>ACA	p.K311T						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;												NA						ACTACAGGAAAAAAATCTCAA	0.448			NA											11	33					0	0	0.001368	0	0
FAM21C	253725	broad.mit.edu	37	10	46261127	46261127	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr10:46261127G>A	uc001jcu.2	+	19	1837	c.1738G>A	c.(1738-1740)GAT>AAT	p.D580N	FAM21C_uc001jcs.1_Missense_Mutation_p.D525N|FAM21C_uc001jct.2_Missense_Mutation_p.D580N|FAM21C_uc010qfi.1_Missense_Mutation_p.D556N|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'UTR	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	580										ovary(1)	1						GCTTTTCTAGGATAATCTTTT	0.403			NA											44	88					0	0	0.00361	0	0
PRF1	5551	broad.mit.edu	37	10	72360376	72360376	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr10:72360376A>G	uc009xqg.2	-	2	444	c.283T>C	c.(283-285)TGG>CGG	p.W95R	PRF1_uc001jrf.3_Missense_Mutation_p.W95R	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	95	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TGGGCCCGCCAGTTGGTGAGC	0.657			NA	M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				7	17					0	0	0.00308	0	0
C10orf79	80217	broad.mit.edu	37	10	105944850	105944850	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr10:105944850T>G	uc001kxw.2	-	16	2181	c.2065A>C	c.(2065-2067)ATG>CTG	p.M689L	C10orf79_uc009xxq.2_5'UTR|C10orf79_uc001kxx.3_Missense_Mutation_p.M690L	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	689	WD 9.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		GAAATTCTCATTGACTGAATC	0.383			NA											5	107					0	0	0.001168	0	0
RPLP2	6181	broad.mit.edu	37	11	812597	812597	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr11:812597T>C	uc001lrq.1	+	4	340	c.235T>C	c.(235-237)TCT>CCT	p.S79P	RPLP2_uc001lrr.1_Missense_Mutation_p.S79P	NM_001004	NP_000995	P05387	RLA2_HUMAN	ribosomal protein P2	79					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCCCCAGGCTCTGCAGCCCC	0.637			NA											7	32					0	0	0.008291	0	0
COPB1	1315	broad.mit.edu	37	11	14512166	14512166	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr11:14512166T>G	uc001mli.2	-	5	858	c.551A>C	c.(550-552)GAG>GCG	p.E184A	COPB1_uc001mlg.2_Missense_Mutation_p.E184A|COPB1_uc001mlh.2_Missense_Mutation_p.E184A	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	184					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						TGCATCCTTCTCATTCACCAG	0.308			NA											3	60					0	0	0.000602	0	0
OR4A5	81318	broad.mit.edu	37	11	51412305	51412305	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr11:51412305G>C	uc001nhi.1	-	1	91	c.91C>G	c.(91-93)CTC>GTC	p.L31V		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				AAGTATGTGAGTAAAAACATG	0.428			NA											19	39					0	0	0.006122	0	0
CCDC88B	283234	broad.mit.edu	37	11	64108420	64108420	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr11:64108420T>G	uc001nzy.2	+	3	292	c.248T>G	c.(247-249)CTT>CGT	p.L83R	CCDC88B_uc009ypo.1_Missense_Mutation_p.L80R|CCDC88B_uc001nzz.1_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	83					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						CTCAGAGGCCTTGACGGACCT	0.667			NA											21	89					0	0	0.005443	0	0
ATM	472	broad.mit.edu	37	11	108236087	108236087	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr11:108236087G>A	uc001pkb.1	+	63	9408	c.9023G>A	c.(9022-9024)CGT>CAT	p.R3008H	ATM_uc009yxr.1_Missense_Mutation_p.R3008H|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.R1660H	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3008			R -> C (in AT, T-prolymphocytic leukemia and mantle cell lymphoma).|R -> H (in B-cell chronic lymphocytic leukemia).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R3008C(4)|p.R3008H(4)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTAGCTGAACGTGTCTTAATG	0.413			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			22	71					0	0	0.002299	0	0
TRIM29	23650	broad.mit.edu	37	11	119996453	119996453	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr11:119996453T>G	uc001pwz.2	-	4	1403	c.1279A>C	c.(1279-1281)ATG>CTG	p.M427L	TRIM29_uc001pwy.2_5'Flank|TRIM29_uc010rzi.1_Missense_Mutation_p.M166L|TRIM29_uc010rzj.1_Missense_Mutation_p.M160L|TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	427					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GCCTTGCACATCTTCTCAACG	0.577			NA											8	44					0	0	0.004482	0	0
SLC6A12	6539	broad.mit.edu	37	12	301809	301809	+	Silent	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:301809A>G	uc001qhz.2	-	16	2079	c.1536T>C	c.(1534-1536)ACT>ACC	p.T512T	SLC6A12_uc001qhx.2_Silent_p.T169T|SLC6A12_uc001qhy.2_Silent_p.T68T|SLC6A12_uc001qia.2_Silent_p.T512T|SLC6A12_uc001qib.2_Silent_p.T512T|SLC6A12_uc009zdh.1_Silent_p.T512T	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	512	Helical; Name=11; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			AGAAGAGGAAAGTGGCCTGGG	0.567			NA											18	46					0	0	0.00499	0	0
KIAA0528	9847	broad.mit.edu	37	12	22680702	22680702	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:22680702G>A	uc001rfq.2	-	4	530	c.302C>T	c.(301-303)GCT>GTT	p.A101V	KIAA0528_uc010sir.1_5'UTR|KIAA0528_uc010sis.1_Missense_Mutation_p.A101V|KIAA0528_uc010sit.1_Missense_Mutation_p.A101V|KIAA0528_uc010siu.1_Missense_Mutation_p.A101V|KIAA0528_uc001rfr.2_Missense_Mutation_p.A101V|KIAA0528_uc009ziy.1_Missense_Mutation_p.A101V	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	101							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GACTGTTGCAGCTTCACTATA	0.323			NA											34	82					0	0	0.005524	0	0
SP1	6667	broad.mit.edu	37	12	53805023	53805023	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:53805023G>A	uc001scw.2	+	6	2454	c.2357G>A	c.(2356-2358)TGA>TAA	p.*786*	SP1_uc010sog.1_Silent_p.*779*	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	786					positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		AATGGCTTCTGAGATCAGGCA	0.552			NA											4	39					0	0	0.000602	0	0
OR6C2	341416	broad.mit.edu	37	12	55846627	55846627	+	Silent	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:55846627T>G	uc001sgz.1	+	1	630	c.630T>G	c.(628-630)GTT>GTG	p.V210V		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCACCCTAGTTTGTGTGATTC	0.408			NA											33	110					0	0	0.003755	0	0
KRR1	11103	broad.mit.edu	37	12	75897801	75897801	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:75897801A>T	uc001sxt.2	-	7	755	c.714T>A	c.(712-714)AGT>AGA	p.S238R	KRR1_uc009zsc.2_Intron	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	238					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						ATCTCTCCCAACTTTGTGATC	0.343			NA											8	124					0	0	0.00308	0	0
UTP20	27340	broad.mit.edu	37	12	101723073	101723073	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:101723073T>G	uc001tia.1	+	27	3419	c.3263T>G	c.(3262-3264)GTT>GGT	p.V1088G		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1088					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TTGTCTAAAGTTCTTCCTTTA	0.413			NA											8	100					0	0	0.00308	0	0
HSP90B1	7184	broad.mit.edu	37	12	104336857	104336857	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:104336857A>T	uc001tkb.1	+	13	1755	c.1650A>T	c.(1648-1650)GAA>GAT	p.E550D	HSP90B1_uc010swg.1_Missense_Mutation_p.E215D|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	550					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	TGTAGGCTGAATCTTCTCCAT	0.373			NA											35	104					0	0	0.002522	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105420361	105420361	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr12:105420361A>C	uc001tlc.2	-	22	2805	c.2678T>G	c.(2677-2679)TTT>TGT	p.F893C	ALDH1L2_uc009zuo.2_Missense_Mutation_p.F348C|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	893	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						AACTCCGCCAAATGGGGCCGC	0.393			NA											30	89					0	0	0.008361	0	0
PABPC3	5042	broad.mit.edu	37	13	25670991	25670991	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr13:25670991A>G	uc001upy.2	+	1	716	c.655A>G	c.(655-657)AGT>GGT	p.S219G		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	219	RRM 3.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GCCCGCCTTAAGTGTGAAAGT	0.418			NA											4	68					0	0	0.000602	0	0
USP12	219333	broad.mit.edu	37	13	27690659	27690659	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr13:27690659T>A	uc001uqy.2	-	2	376	c.123A>T	c.(121-123)TTA>TTT	p.L41F		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	41					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TTACATTGACTAATCCAAAAT	0.343	Ovarian(37;808 911 7590 44442 44991)		NA											15	28					0	0	0.003163	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33091950	33091950	+	Missense_Mutation	SNP	T	T	G	rs138840363		TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr13:33091950T>G	uc001uuk.3	-	6	1919	c.1741A>C	c.(1741-1743)AAT>CAT	p.N581H	N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010abe.1_Intron|N4BP2L2_uc010tdz.1_Intron	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	581											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TAATGATTATTTGTGACACAG	0.408			NA											3	35					0	0	0.004672	0	0
LRCH1	23143	broad.mit.edu	37	13	47224374	47224374	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr13:47224374T>A	uc001vbj.2	+	2	582	c.346T>A	c.(346-348)TTG>ATG	p.L116M	LRCH1_uc010acp.2_Missense_Mutation_p.L116M|LRCH1_uc001vbk.2_Missense_Mutation_p.L116M|LRCH1_uc001vbl.3_Missense_Mutation_p.L116M	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	116	LRR 1.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TCCAATGGAATTGTGCCATTT	0.333			NA											10	30					0	0	0.006214	0	0
KIAA1370	56204	broad.mit.edu	37	15	52874472	52874472	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr15:52874472A>T	uc002acg.3	-	13	3263	c.3110T>A	c.(3109-3111)CTC>CAC	p.L1037H	KIAA1370_uc002ach.3_RNA|KIAA1370_uc002acf.3_Missense_Mutation_p.L67H|KIAA1370_uc010ugf.1_Missense_Mutation_p.L1044H	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	1037											0				all cancers(107;0.0803)		GTCTCTATGGAGGTAGATCTT	0.358			NA											12	18					0	0	0.003163	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58306126	58306126	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr15:58306126T>C	uc002aex.2	-	3	351	c.293A>G	c.(292-294)GAT>GGT	p.D98G	ALDH1A2_uc002aey.2_Missense_Mutation_p.D98G|ALDH1A2_uc010ugv.1_Missense_Mutation_p.D77G|ALDH1A2_uc010ugw.1_Missense_Mutation_p.D69G|ALDH1A2_uc002aew.2_Missense_Mutation_p.D2G	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	98					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTCTGAAGCATCCATCCTTCT	0.483			NA											94	190					0	0	0.00361	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157638	65157638	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr15:65157638T>C	uc002anv.2	+	6	1158	c.1024T>C	c.(1024-1026)TCA>CCA	p.S342P	PLEKHO2_uc010bgz.2_Missense_Mutation_p.S18P|PLEKHO2_uc002anw.2_Missense_Mutation_p.S292P	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	342	Pro-rich.									ovary(1)|lung(1)	2						AGTGCAGGTCTCAGTGAATGG	0.577			NA											3	32					0	0	0.004672	0	0
ABCC6	368	broad.mit.edu	37	16	16256971	16256971	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr16:16256971C>A	uc002den.3	-	24	3422	c.3385G>T	c.(3385-3387)GAG>TAG	p.E1129*	ABCC6_uc010bvo.2_Intron	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1129	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TGGAACGTCTCAGCCATGTGG	0.567			NA											25	56					5.35356e-11	5.67054e-11	0.00278	1	0
TNRC6A	27327	broad.mit.edu	37	16	24800787	24800787	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr16:24800787A>C	uc002dmm.2	+	6	938	c.824A>C	c.(823-825)AAC>ACC	p.N275T	TNRC6A_uc010bxs.2_Missense_Mutation_p.N22T|TNRC6A_uc010vcc.1_Missense_Mutation_p.N22T|TNRC6A_uc002dmn.2_Missense_Mutation_p.N22T|TNRC6A_uc002dmo.2_Missense_Mutation_p.N22T	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	275	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Ser-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GCTTCAGGGAACACAGGTGGT	0.483			NA											4	102					0	0	0.009096	0	0
CYLD	1540	broad.mit.edu	37	16	50783950	50783950	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr16:50783950A>C	uc002egp.1	+	4	756	c.341A>C	c.(340-342)AAA>ACA	p.K114T	CYLD_uc002egn.1_Missense_Mutation_p.K114T|CYLD_uc002ego.2_Missense_Mutation_p.K114T|CYLD_uc010cbs.1_Missense_Mutation_p.K114T|CYLD_uc002egq.1_Missense_Mutation_p.K114T|CYLD_uc002egr.1_Missense_Mutation_p.K114T|CYLD_uc002egs.1_Missense_Mutation_p.K114T	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	114	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AGCCTGTTTAAAAACAGAAAC	0.403			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				8	128					0	0	0.00308	0	0
GALNS	2588	broad.mit.edu	37	16	88898418	88898418	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr16:88898418G>A	uc002fly.3	-	9	1079	c.990C>T	c.(988-990)GTC>GTT	p.V330V	GALNS_uc010cid.2_Silent_p.V336V|GALNS_uc002flz.3_Silent_p.V13V	NM_000512	NP_000503	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	330						lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GGCCTGCAGTGACGTGCCCTG	0.677	GBM(129;1929 2344 25209 33204)		NA											15	16					0	0	0.00245	0	0
GAS7	8522	broad.mit.edu	37	17	9828912	9828912	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:9828912C>T	uc002gmg.1	-	11	1180	c.1019G>A	c.(1018-1020)CGG>CAG	p.R340Q	GAS7_uc010vvc.1_Missense_Mutation_p.R154Q|GAS7_uc002gmh.1_Missense_Mutation_p.R200Q|GAS7_uc010vvd.1_Missense_Mutation_p.R292Q|GAS7_uc002gmi.2_Missense_Mutation_p.R276Q|GAS7_uc002gmj.1_Missense_Mutation_p.R280Q|GAS7_uc010coh.1_Missense_Mutation_p.R280Q	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	340	Potential.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						GAGGGCTTTCCGGGCCTGGGG	0.617			NA	T	MLL	AML*								24	16					0	0	0.00278	0	0
NCOR1	9611	broad.mit.edu	37	17	15938112	15938112	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:15938112C>G	uc002gpo.2	-	45	7342	c.7102G>C	c.(7102-7104)GGG>CGG	p.G2368R	NCOR1_uc002gpn.2_Missense_Mutation_p.G2265R|NCOR1_uc002gpl.2_Missense_Mutation_p.G382R|NCOR1_uc002gpm.2_Missense_Mutation_p.G887R|NCOR1_uc010vwb.1_Missense_Mutation_p.G952R|NCOR1_uc010coy.2_Missense_Mutation_p.G1276R	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2368	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGCCCACCCTGGCGTCTGC	0.468			NA											5	110					0	0	0.000602	0	0
NCOR1	9611	broad.mit.edu	37	17	16062117	16062117	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:16062117T>C	uc002gpo.2	-	6	929	c.689A>G	c.(688-690)CAG>CGG	p.Q230R	NCOR1_uc002gpn.2_Missense_Mutation_p.Q230R|NCOR1_uc002gpp.1_Missense_Mutation_p.Q121R|NCOR1_uc002gpr.2_Missense_Mutation_p.Q121R|NCOR1_uc002gps.1_Missense_Mutation_p.Q230R|NCOR1_uc010coz.1_Missense_Mutation_p.Q46R|NCOR1_uc010cpb.1_Missense_Mutation_p.Q230R|NCOR1_uc010cpa.1_Missense_Mutation_p.Q230R	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	230	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCGGTGTTTCTGCTCCACAGG	0.493			NA											3	58					0	0	0.009096	0	0
C17orf104	284071	broad.mit.edu	37	17	42744680	42744680	+	Silent	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:42744680T>G	uc010czv.2	+	5	1401	c.1401T>G	c.(1399-1401)TCT>TCG	p.S467S	C17orf104_uc002igy.1_Silent_p.S301S|C17orf104_uc002igz.3_Silent_p.S301S|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Silent_p.S301S	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	467										central_nervous_system(1)	1						CAGCAACATCTTCAGGAGGTA	0.328			NA											43	133					0	0	0.007835	0	0
GFAP	2670	broad.mit.edu	37	17	42988815	42988815	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:42988815G>A	uc002ihq.2	-	6	976	c.916C>T	c.(916-918)CTG>TTG	p.L306L	GFAP_uc002ihr.2_Silent_p.L306L|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	306	Coil 2B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				TGCCTCTCCAGGGACTCGTTC	0.592			NA											12	40					0	0	0.001368	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626586	44626586	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:44626586T>C	uc002ikn.1	+	9	4084	c.4081T>C	c.(4081-4083)TCC>CCC	p.S1361P	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Missense_Mutation_p.S322P|LRRC37A2_uc010dax.1_Missense_Mutation_p.S291P	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1361	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		GGCTTTTTCATCCTTAGGAGA	0.413			NA											13	160					0	0	0.00333	0	0
TOB1	10140	broad.mit.edu	37	17	48941171	48941171	+	Nonsense_Mutation	SNP	G	G	A	rs142442521	by1000genomes	TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:48941171G>A	uc002isw.2	-	1	243	c.208C>T	c.(208-210)CAA>TAA	p.Q70*	TOB1_uc010wmy.1_Nonsense_Mutation_p.Q70*|TOB1_uc010wmz.1_Nonsense_Mutation_p.Q70*	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	70					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TTGGATGCTTGTTCAATCACT	0.428	NSCLC(144;643 1919 24513 29423 40686)		NA											14	196					0	0	0.001855	0	0
ANKFN1	162282	broad.mit.edu	37	17	54517778	54517778	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:54517778T>C	uc002iun.1	+	8	1045	c.1010T>C	c.(1009-1011)CTT>CCT	p.L337P		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	337	Fibronectin type-III.									large_intestine(1)|ovary(1)	2						ATCACAGGACTTACAATGGTA	0.428			NA											4	81					0	0	0.009096	0	0
TBX4	9496	broad.mit.edu	37	17	59543207	59543207	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr17:59543207A>C	uc002izi.2	+	3	354	c.309A>C	c.(307-309)AAA>AAC	p.K103N	TBX4_uc010ddo.2_Missense_Mutation_p.K103N|TBX4_uc010woy.1_Missense_Mutation_p.K103N	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	103	T-box.				leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ACAAGGTAAAAGTCACAGGCA	0.542			NA											15	66					0	0	0.003163	0	0
DSG4	147409	broad.mit.edu	37	18	28979256	28979256	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:28979256C>T	uc002kwq.2	+	9	1162	c.1027C>T	c.(1027-1029)CCT>TCT	p.P343S	DSG4_uc002kwr.2_Missense_Mutation_p.P343S	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	343	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGAACAAGCACCTAACATTCA	0.373			NA											30	71					0	0	0.008361	0	0
MCART2	147407	broad.mit.edu	37	18	29340050	29340050	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:29340050C>T	uc002kxa.2	-	1	794	c.575G>A	c.(574-576)GGC>GAC	p.G192D		NM_001034172	NP_001029344	Q3SY17	MCAR2_HUMAN	mitochondrial carrier triple repeat 2	192	Helical; Name=4; (Potential).|Solcar 2.				transport	integral to membrane|mitochondrial inner membrane				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.0539)			ACCTCGAAGGCCGAAAAACAA	0.478			NA											10	68					0	0	0.008291	0	0
ZNF271	10778	broad.mit.edu	37	18	32886980	32886980	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:32886980T>C	uc002kyq.3	+	3	1384	c.392T>C	c.(391-393)TTC>TCC	p.F131S	ZNF271_uc002kyp.3_Missense_Mutation_p.F131S|ZNF271_uc002kyr.3_Missense_Mutation_p.F131S	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						ATCACAGAATTCATACAGGTG	0.383			NA											4	63					0	0	0.009096	0	0
KIAA1632	57724	broad.mit.edu	37	18	43462310	43462310	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:43462310T>G	uc002lbm.2	-	31	5547	c.5447A>C	c.(5446-5448)AAG>ACG	p.K1816T	KIAA1632_uc010xcq.1_Missense_Mutation_p.K370T|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.K691T	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1816					autophagy						0						AGTCCAGTGCTTACAGAAAAG	0.423			NA											22	39					0	0	0.00278	0	0
KIAA1632	57724	broad.mit.edu	37	18	43534828	43534828	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:43534828T>G	uc002lbm.2	-	2	640	c.540A>C	c.(538-540)GAA>GAC	p.E180D	KIAA1632_uc002lbo.1_Missense_Mutation_p.E180D	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	180					autophagy						0						CTTGTTTGTCTTCTTTACTAT	0.418			NA											7	57					0	0	0.001984	0	0
MYO5B	4645	broad.mit.edu	37	18	47462675	47462675	+	Silent	SNP	C	C	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:47462675C>G	uc002leb.2	-	16	2238	c.1950G>C	c.(1948-1950)ACG>ACC	p.T650T	MYO5B_uc002lec.1_Silent_p.T649T	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	650	Myosin head-like.|Actin-binding (Potential).				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGTGAGGTGTCGTGGCATTCA	0.517			NA											2	6					0	0	0.004672	0	0
SERPINB5	5268	broad.mit.edu	37	18	61160237	61160237	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr18:61160237T>G	uc002liz.3	+	5	618	c.476T>G	c.(475-477)ATC>AGC	p.I159S	SERPINB5_uc002liy.2_Missense_Mutation_p.I159S	NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade	159					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1						CAGACCAAAATCCTTGTGGTT	0.388			NA											6	223					0	0	0.001168	0	0
KLF16	83855	broad.mit.edu	37	19	1854696	1854696	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:1854696A>G	uc002luc.2	-	2	589	c.521T>C	c.(520-522)CTG>CCG	p.L174P	KLF16_uc010xgt.1_RNA	NM_031918	NP_114124	Q9BXK1	KLF16_HUMAN	BTE-binding protein 4	174	C2H2-type 2.					nucleus	DNA binding|zinc ion binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGCGGGCCAGCTCGTCGGA	0.672			NA											4	26					0	0	0.006214	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739364	15739364	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:15739364T>G	uc002nbi.2	+	13	1337	c.1273T>G	c.(1273-1275)TTC>GTC	p.F425V	CYP4F8_uc010xoj.1_Missense_Mutation_p.F237V	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	425					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CATCAACATCTTCGCAATCCA	0.622			NA											30	206					0	0	0.002445	0	0
PIK3R2	5296	broad.mit.edu	37	19	18279608	18279608	+	Silent	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:18279608C>T	uc002nia.1	+	15	2393	c.1881C>T	c.(1879-1881)ATC>ATT	p.I627I	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	627	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						TGGGCAAGATCAACCGCACGC	0.667			NA									OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	0.004672	0	0
NCAN	1463	broad.mit.edu	37	19	19338102	19338102	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:19338102G>A	uc002nlz.2	+	8	1772	c.1673G>A	c.(1672-1674)GGC>GAC	p.G558D	NCAN_uc010ecc.1_Missense_Mutation_p.G122D	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	558					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TCTGCTGGTGGCAAGAGCTCC	0.607			NA											8	98					0	0	0.004482	0	0
PSG2	5670	broad.mit.edu	37	19	43576000	43576000	+	Silent	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:43576000A>G	uc002ovr.2	-	4	909	c.816T>C	c.(814-816)TCT>TCC	p.S272S	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.S272S|PSG2_uc010eiq.1_Silent_p.S272S|PSG2_uc002ovs.3_Silent_p.S272S|PSG2_uc002ovt.3_Silent_p.S272S	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	272	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				TAATTGTCCAAGAATACTGTG	0.443			NA											51	55					0	0	0.00361	0	0
PSG2	5670	broad.mit.edu	37	19	43576051	43576051	+	Missense_Mutation	SNP	A	A	C	rs1058095		TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:43576051A>C	uc002ovr.2	-	4	858	c.765T>G	c.(763-765)GAT>GAG	p.D255E	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.D255E|PSG2_uc010eiq.1_Missense_Mutation_p.D255E|PSG2_uc002ovs.3_Missense_Mutation_p.D255E|PSG2_uc002ovt.3_Missense_Mutation_p.D255E	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	255	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				AGTAGAGGTTATCTCCTGAAC	0.458			NA											62	47					0	0	0.00361	0	0
SPHK2	56848	broad.mit.edu	37	19	49132515	49132515	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:49132515T>C	uc002pjr.2	+	7	1816	c.1450T>C	c.(1450-1452)TCA>CCA	p.S484P	SPHK2_uc010xzt.1_Missense_Mutation_p.S425P|SPHK2_uc002pjs.2_Missense_Mutation_p.S484P|SPHK2_uc002pjt.2_Missense_Mutation_p.S278P|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Missense_Mutation_p.S448P|SPHK2_uc002pjw.2_Missense_Mutation_p.S546P	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	484					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		AGCTCTACACTCACCCGTCTC	0.697			NA											8	91					0	0	0.008291	0	0
LHB	3972	broad.mit.edu	37	19	49519935	49519935	+	Missense_Mutation	SNP	C	C	T	rs146354951	byFrequency	TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:49519935C>T	uc002plt.2	-	2	61	c.52G>A	c.(52-54)GCA>ACA	p.A18T		NM_000894	NP_000885	P01229	LSHB_HUMAN	luteinizing hormone beta subunit precursor	18					cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	GATGCCCATGCCCCGCCCATG	0.647			NA											3	45					0	0	0.004672	0	0
APOB	338	broad.mit.edu	37	2	21233338	21233338	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:21233338T>G	uc002red.2	-	26	6530	c.6402A>C	c.(6400-6402)CAA>CAC	p.Q2134H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2134	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATGTGAAACTTGTCTCTCCC	0.343			NA											5	39					0	0	0.000602	0	0
SRBD1	55133	broad.mit.edu	37	2	45778344	45778344	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:45778344C>T	uc002rus.2	-	12	1671	c.1595G>A	c.(1594-1596)AGC>AAC	p.S532N	SRBD1_uc010yoc.1_Missense_Mutation_p.S51N	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	532					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TGGAACAGGGCTTGTTAAAAG	0.393			NA											5	43					0	0	0.000602	0	0
ANTXR1	84168	broad.mit.edu	37	2	69330049	69330049	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:69330049A>C	uc002sfg.2	+	10	1135	c.779A>C	c.(778-780)AAG>ACG	p.K260T	ANTXR1_uc002sfe.2_Missense_Mutation_p.K260T|ANTXR1_uc002sff.2_Missense_Mutation_p.K260T|ANTXR1_uc002sfd.2_Missense_Mutation_p.K260T|hsa-mir-3126|MI0014143_5'Flank	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	260	Extracellular (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						TGCAGCTTCAAGATCAATGAC	0.493			NA							Familial_Infantile_Hemangioma				61	130					0	0	0.00361	0	0
RETSAT	54884	broad.mit.edu	37	2	85570424	85570424	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:85570424A>C	uc002spd.2	-	11	1965	c.1774T>G	c.(1774-1776)TTG>GTG	p.L592V	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.L531V|RETSAT_uc010fgf.2_Missense_Mutation_p.L383V	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	592					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	TCTGAGTACAAGTTCCGCTTC	0.537			NA											20	43					0	0	0.010504	0	0
HS6ST1	9394	broad.mit.edu	37	2	129025897	129025897	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:129025897A>G	uc002tpt.3	-	2	1109	c.1075T>C	c.(1075-1077)TAC>CAC	p.Y359H		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	359	Potential.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		TTGTACTGGTAGCGCTGCTGG	0.662			NA											18	54					0	0	0.007413	0	0
LCT	3938	broad.mit.edu	37	2	136581471	136581471	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:136581471C>T	uc002tuu.1	-	4	918	c.907G>A	c.(907-909)GCC>ACC	p.A303T		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	303	Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCCCACTCACCTTCAAAAAGG	0.502			NA											9	32					0	0	0.008291	0	0
SLC4A10	57282	broad.mit.edu	37	2	162696373	162696373	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:162696373T>G	uc002ubx.3	+	4	536	c.352T>G	c.(352-354)TTC>GTC	p.F118V	SLC4A10_uc010fpa.1_Missense_Mutation_p.F130V|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.F118V|SLC4A10_uc010zcs.1_Missense_Mutation_p.F129V	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	118	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TCATGACCTTTTCACAGAACT	0.443			NA											5	67					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179572258	179572258	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:179572258A>C	uc010zfg.1	-	97	25528	c.25304T>G	c.(25303-25305)ATT>AGT	p.I8435S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I5096S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9362							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTACCTTTAATGGTCACTTT	0.383			NA											11	17					0	0	0.000978	0	0
CERKL	375298	broad.mit.edu	37	2	182403906	182403906	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:182403906T>G	uc002unx.2	-	13	1630	c.1529A>C	c.(1528-1530)GAG>GCG	p.E510A	CERKL_uc002uny.2_Missense_Mutation_p.E484A|CERKL_uc010zfm.1_Missense_Mutation_p.E466A|CERKL_uc002unz.2_Missense_Mutation_p.E232A|CERKL_uc002uoa.2_Missense_Mutation_p.E415A|CERKL_uc002uob.2_Missense_Mutation_p.E232A|CERKL_uc002uoc.2_Missense_Mutation_p.E371A|CERKL_uc010frk.2_RNA|CERKL_uc002unw.2_Missense_Mutation_p.E80A	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	510					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATCCTCCTCCTCCTCTGGATT	0.353			NA											33	49					0	0	0.009535	0	0
TMEM198	130612	broad.mit.edu	37	2	220412409	220412409	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:220412409G>A	uc002vme.2	+	4	933	c.348G>A	c.(346-348)GTG>GTA	p.V116V	TMEM198_uc002vmf.2_Silent_p.V116V	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	116	Leu-rich.|Helical; (Potential).					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGCGCAGCGTGGGCCTCTTCC	0.701			NA											7	49					0	0	0.001984	0	0
DEFB125	245938	broad.mit.edu	37	20	76828	76828	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr20:76828G>T	uc002wcw.2	+	2	241	c.241G>T	c.(241-243)GAT>TAT	p.D81Y		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	81					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			TATAACATTGGATTATAGTGA	0.368			NA											57	114					2.47907e-22	2.66086e-22	0.00361	1	0
TIAM1	7074	broad.mit.edu	37	21	32492740	32492740	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr21:32492740A>C	uc002yow.1	-	29	5194	c.4722T>G	c.(4720-4722)ATT>ATG	p.I1574M	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Missense_Mutation_p.I1514M	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1574					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCTAACCCAAATGACTTCCT	0.562			NA											11	25					0	0	0.001855	0	0
SLC37A1	54020	broad.mit.edu	37	21	43945903	43945903	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr21:43945903T>G	uc002zbi.2	+	4	486	c.74T>G	c.(73-75)TTT>TGT	p.F25C	SLC37A1_uc002zbj.2_Missense_Mutation_p.F25C	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	25	Helical; (Potential).				carbohydrate transport|transmembrane transport	integral to membrane					0						GCCTTCATTTTTATTTTGACA	0.373			NA											4	46					0	0	0.001168	0	0
PWP2	5822	broad.mit.edu	37	21	45540652	45540652	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr21:45540652T>C	uc002zeb.2	+	12	1568	c.1478T>C	c.(1477-1479)CTC>CCC	p.L493P		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	493	WD 10.					cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		ACAGGCAGGCTCCTTGATGTA	0.632			NA											13	41					0	0	0.00499	0	0
MICAL3	57553	broad.mit.edu	37	22	18389374	18389374	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr22:18389374A>C	uc002zng.3	-	2	558	c.205T>G	c.(205-207)TTG>GTG	p.L69V	MICAL3_uc011agl.1_Missense_Mutation_p.L69V|MICAL3_uc002znh.2_Missense_Mutation_p.L69V|MICAL3_uc002znk.1_Missense_Mutation_p.L69V|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Missense_Mutation_p.L69V|MICAL3_uc011agm.1_Missense_Mutation_p.L69V	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	69						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CGTTTGTCCAATTTTGCCCAG	0.502			NA											53	109					0	0	0.00361	0	0
ZNF74	7625	broad.mit.edu	37	22	20754938	20754938	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr22:20754938A>C	uc010gsm.2	+	4	349	c.137A>C	c.(136-138)AAG>ACG	p.K46T	ZNF74_uc002zsg.2_5'UTR|ZNF74_uc002zsh.2_Missense_Mutation_p.K46T|ZNF74_uc002zsi.2_5'UTR|ZNF74_uc010gsn.2_5'UTR	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	46	KRAB.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GTGAGTTTCAAGGATGTGGCT	0.502			NA											15	45					0	0	0.004007	0	0
EFHB	151651	broad.mit.edu	37	3	19921190	19921190	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:19921190T>G	uc003cbl.3	-	13	2631	c.2435A>C	c.(2434-2436)GAG>GCG	p.E812A	EFHB_uc003cbm.2_Missense_Mutation_p.E682A	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	812					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						TCTGATGTTCTCAACACAAAC	0.363			NA											33	98					0	0	0.002836	0	0
GOLGA4	2803	broad.mit.edu	37	3	37365668	37365668	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:37365668T>C	uc003cgv.2	+	14	2595	c.2291T>C	c.(2290-2292)CTC>CCC	p.L764P	GOLGA4_uc010hgr.1_Missense_Mutation_p.L325P|GOLGA4_uc003cgw.2_Missense_Mutation_p.L786P|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.L645P	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	764	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CTTGAGCTTCTCTTGAAGGAA	0.408			NA											5	74					0	0	0.001168	0	0
PARP3	10039	broad.mit.edu	37	3	51978834	51978834	+	Missense_Mutation	SNP	A	A	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:51978834A>T	uc003dby.2	+	5	913	c.542A>T	c.(541-543)CAG>CTG	p.Q181L	RRP9_uc003dbw.1_5'Flank|PARP3_uc003dbz.2_Missense_Mutation_p.Q188L	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	181					DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AAGCGGGTGCAGCCCTGCTCC	0.602			NA											7	14					0	0	0.00308	0	0
SLC15A2	6565	broad.mit.edu	37	3	121641974	121641974	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:121641974C>A	uc003eep.2	+	10	1108	c.955C>A	c.(955-957)CAG>AAG	p.Q319K	SLC15A2_uc011bjn.1_Missense_Mutation_p.Q288K	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	319					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TTTGGATCAGCAGGTAAGAAT	0.458			NA											4	127					0.00909568	0.00938721	0.009096	1	0
PLXND1	23129	broad.mit.edu	37	3	129305021	129305021	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:129305021T>C	uc003emx.2	-	4	1815	c.1715A>G	c.(1714-1716)GAG>GGG	p.E572G		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	572	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TCACCGCGTCTCCAGGGCACA	0.701	Ovarian(97;366 1484 3738 22084 39045)		NA											4	6					0	0	0.001168	0	0
ACAD11	84129	broad.mit.edu	37	3	132360968	132360968	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:132360968A>C	uc003eov.3	-	4	765	c.385T>G	c.(385-387)TTC>GTC	p.F129V	ACAD11_uc003eoy.2_Missense_Mutation_p.F129V	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	129						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						AAATCACGGAAGATTCGACCC	0.353			NA											20	55					0	0	0.00333	0	0
HPS3	84343	broad.mit.edu	37	3	148880568	148880568	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:148880568T>G	uc003ewu.1	+	13	2524	c.2384T>G	c.(2383-2385)CTT>CGT	p.L795R	HPS3_uc011bnq.1_Missense_Mutation_p.L630R|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	795						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GATGTGGTACTTCAGGAACTC	0.458			NA							Hermansky-Pudlak_syndrome				28	62					0	0	0.009535	0	0
TNFSF10	8743	broad.mit.edu	37	3	172224294	172224294	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr3:172224294A>C	uc003fid.2	-	5	929	c.834T>G	c.(832-834)TTT>TTG	p.F278L	TNFSF10_uc003fie.2_3'UTR	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	278	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGCCAACTAAAAAGGCCCCAA	0.363			NA											4	75					0	0	0.009096	0	0
WDR19	57728	broad.mit.edu	37	4	39201143	39201143	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:39201143A>C	uc003gtv.2	+	6	606	c.452A>C	c.(451-453)AAT>ACT	p.N151T	WDR19_uc010ifl.1_Intron|WDR19_uc003gtu.1_Missense_Mutation_p.N151T|WDR19_uc011byi.1_5'UTR	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	151	WD 4.				cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AATGCAGAAAATCTGCTTGCT	0.338			NA											14	48					0	0	0.004007	0	0
EXOC1	55763	broad.mit.edu	37	4	56724547	56724547	+	Silent	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:56724547C>T	uc003hbe.1	+	2	216	c.58C>T	c.(58-60)CTG>TTG	p.L20L	EXOC1_uc003hbf.1_Silent_p.L20L|EXOC1_uc003hbg.1_Silent_p.L20L	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	20					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					TGATGAACGCCTGCTGAGCAT	0.363			NA											44	83					0	0	0.00361	0	0
REST	5978	broad.mit.edu	37	4	57797750	57797750	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:57797750T>G	uc003hch.2	+	4	3073	c.2726T>G	c.(2725-2727)CTT>CGT	p.L909R	REST_uc003hci.2_Missense_Mutation_p.L909R|REST_uc010ihf.2_Missense_Mutation_p.L583R	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	909					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					CTACCTGGTCTTGCTGCTAAT	0.428			NA											3	74					0	0	0.004672	0	0
UBA6	55236	broad.mit.edu	37	4	68506908	68506908	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:68506908G>A	uc003hdg.3	-	18	1567	c.1515C>T	c.(1513-1515)AAC>AAT	p.N505N	UBA6_uc003hdh.1_Silent_p.N31N	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	505					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						GTCTATTTAAGTTGGATTTCT	0.279			NA											69	136					0	0	0.00361	0	0
RUFY3	22902	broad.mit.edu	37	4	71665865	71665865	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:71665865A>C	uc003hfr.2	+	15	2160	c.1565A>C	c.(1564-1566)AAG>ACG	p.K522T	RUFY3_uc011cay.1_Missense_Mutation_p.K458T	NM_001037442	NP_001032519	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			CAGGATGGGAAGCACAAAATG	0.328			NA											9	26					0	0	0.008291	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99337939	99337939	+	Silent	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:99337939T>C	uc003htx.3	+	8	997	c.807T>C	c.(805-807)TGT>TGC	p.C269C	RAP1GDS1_uc003htw.3_Silent_p.C270C|RAP1GDS1_uc003htv.3_Silent_p.C270C|RAP1GDS1_uc003htz.3_Silent_p.C220C|RAP1GDS1_uc003hty.3_Silent_p.C221C|RAP1GDS1_uc003hua.3_Silent_p.C178C	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	269							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TAGTAGAGTGTCTACTAGAGA	0.363			NA	T	NUP98	T-ALL								24	67					0	0	0.002299	0	0
CCDC109B	55013	broad.mit.edu	37	4	110606516	110606516	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:110606516T>G	uc011cfs.1	+	7	1065	c.926T>G	c.(925-927)CTT>CGT	p.L309R		NM_017918	NP_060388	Q9NWR8	C109B_HUMAN	coiled-coil domain containing 109B	309	Potential.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;6.65e-06)		AAAGAAGACCTTGCTAAGGTA	0.378			NA											12	36					0	0	0.001368	0	0
VEGFC	7424	broad.mit.edu	37	4	177605128	177605128	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr4:177605128T>G	uc003ius.1	-	7	1642	c.1212A>C	c.(1210-1212)GAA>GAC	p.E404D		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	404					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		AACGACACACTTCTTCACTAT	0.403			NA											23	84					0	0	0.00278	0	0
ANKRD55	79722	broad.mit.edu	37	5	55422837	55422837	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:55422837T>G	uc003jqu.2	-	8	861	c.709A>C	c.(709-711)ATC>CTC	p.I237L		NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	236	ANK 7.									skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GCCGCTGCGATATGTACACAT	0.502			NA											46	128					0	0	0.00361	0	0
TAF9	6880	broad.mit.edu	37	5	68660800	68660800	+	Silent	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:68660800A>G	uc003jwc.1	-	2	1097	c.765T>C	c.(763-765)GAT>GAC	p.D255D	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_Silent_p.D255D|TAF9_uc003jwe.1_Silent_p.D255D|TAF9_uc003jwf.1_Silent_p.D255D	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	255	Poly-Asp.				histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		catcatcatcatcgtcatcat	0.244			NA											4	121					0	0	0.009096	0	0
POLK	51426	broad.mit.edu	37	5	74892214	74892214	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:74892214A>G	uc003kdw.2	+	13	1792	c.1696A>G	c.(1696-1698)AGT>GGT	p.S566G	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.S368G|POLK_uc003kec.2_Missense_Mutation_p.S476G|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.S476G	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	566					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TCATAAGAAGAGTTTCTTTGA	0.363			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					6	76					0	0	0.001984	0	0
ERAP2	64167	broad.mit.edu	37	5	96253179	96253179	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:96253179T>G	uc003kmq.2	+	19	3463	c.2753T>G	c.(2752-2754)TTT>TGT	p.F918C	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.F918C|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.F867C|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	918	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		AAACTATTTTTTGAATCTCTT	0.244			NA											22	113					0	0	0.00278	0	0
PCDHA4	56144	broad.mit.edu	37	5	140189052	140189052	+	Silent	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:140189052T>C	uc003lhi.2	+	1	2381	c.2280T>C	c.(2278-2280)TCT>TCC	p.S760S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.S760S|PCDHA4_uc011daa.1_Silent_p.S760S	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	760	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGTGCTCTGGTGAGGGCC	0.632			NA											4	104					0	0	0.000602	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209755	140209755	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:140209755G>A	uc003lho.2	+	1	2106	c.2079G>A	c.(2077-2079)CTG>CTA	p.L693L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.L693L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	693	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCGGCGCTGGTGGATGTCA	0.677			NA											42	31					0	0	0.007835	0	0
PCDHB6	56130	broad.mit.edu	37	5	140529864	140529864	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:140529864A>C	uc003lir.2	+	1	26	c.26A>C	c.(25-27)AAG>ACG	p.K9T	PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	9					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTACAGAACAAGAAAAGGCAA	0.433			NA											4	159					0	0	0.009096	0	0
NMUR2	56923	broad.mit.edu	37	5	151784142	151784142	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr5:151784142G>A	uc003luv.2	-	1	699	c.533C>T	c.(532-534)TCC>TTC	p.S178F		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	178	Helical; Name=4; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GTTGGGCAGGGAGAAGAGCAC	0.627			NA											31	77					0	0	0.007291	0	0
TDP2	51567	broad.mit.edu	37	6	24651080	24651080	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:24651080A>G	uc003nej.2	-	7	1050	c.1025T>C	c.(1024-1026)CTG>CCG	p.L342P	TDP2_uc003nei.2_Missense_Mutation_p.L230P	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	342					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						ACCACAGTCCAGTTTTTCTAA	0.403			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					22	52					0	0	0.00278	0	0
ZNF391	346157	broad.mit.edu	37	6	27368305	27368305	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:27368305A>C	uc003njf.1	+	3	674	c.156A>C	c.(154-156)GAA>GAC	p.E52D		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						CACTCAAAGAAATTTTCACAG	0.423			NA											32	64					0	0	0.002096	0	0
PGBD1	84547	broad.mit.edu	37	6	28264604	28264604	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:28264604G>A	uc003nky.2	+	5	1024	c.654G>A	c.(652-654)AAG>AAA	p.K218K	PGBD1_uc003nkz.2_Silent_p.K218K	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	218					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CATTGGTGAAGACTGAGGAAG	0.463			NA											14	71					0	0	0.00245	0	0
PGBD1	84547	broad.mit.edu	37	6	28264610	28264610	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:28264610G>A	uc003nky.2	+	5	1030	c.660G>A	c.(658-660)GAG>GAA	p.E220E	PGBD1_uc003nkz.2_Silent_p.E220E	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	220					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGAAGACTGAGGAAGAAACAG	0.468			NA											13	68					0	0	0.001855	0	0
PGBD1	84547	broad.mit.edu	37	6	28264697	28264697	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:28264697G>C	uc003nky.2	+	5	1117	c.747G>C	c.(745-747)GAG>GAC	p.E249D	PGBD1_uc003nkz.2_Missense_Mutation_p.E249D	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	249					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CAGCTCAGGAGACAGTTATGA	0.567			NA											9	47					0	0	0.004482	0	0
PGBD1	84547	broad.mit.edu	37	6	28265725	28265725	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:28265725G>A	uc003nky.2	+	6	1196	c.826G>A	c.(826-828)GAA>AAA	p.E276K	PGBD1_uc003nkz.2_Missense_Mutation_p.E276K	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	276					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AGAAACTTCTGAAGAAATGGA	0.343			NA											12	63					0	0	0.000978	0	0
PGBD1	84547	broad.mit.edu	37	6	28265744	28265744	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:28265744G>C	uc003nky.2	+	6	1215	c.845G>C	c.(844-846)GGA>GCA	p.G282A	PGBD1_uc003nkz.2_Missense_Mutation_p.G282A	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	282					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						GAACAAAGTGGAGAAGCCTCA	0.353			NA											13	53					0	0	0.00245	0	0
C2	717	broad.mit.edu	37	6	31912805	31912805	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:31912805A>G	uc003nyf.2	+	17	2342	c.2078A>G	c.(2077-2079)CAG>CGG	p.Q693R	C2_uc011doo.1_Missense_Mutation_p.Q447R|C2_uc011dop.1_Missense_Mutation_p.Q479R|C2_uc010jtk.2_Missense_Mutation_p.Q561R|C2_uc011doq.1_Missense_Mutation_p.Q664R|C2_uc003nyg.2_Missense_Mutation_p.Q470R|CFB_uc011dor.1_Intron|C2_uc003nyh.1_Intron|CFB_uc011dos.1_5'Flank|CFB_uc003nyi.2_5'Flank|CFB_uc003nyj.3_5'Flank	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	693	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		AGGTTTTTTCAGGTGAGAAGG	0.552			NA											3	124					0	0	0.009096	0	0
TRERF1	55809	broad.mit.edu	37	6	42231109	42231109	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:42231109G>A	uc003osd.2	-	8	2396	c.1833C>T	c.(1831-1833)TCC>TCT	p.S611S	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Silent_p.S611S	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	611	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGTCTCTGGCGGAGGGGGCGG	0.657			NA											5	82					0	0	0.000602	0	0
TTK	7272	broad.mit.edu	37	6	80723075	80723075	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr6:80723075A>C	uc003pjc.2	+	9	1050	c.976A>C	c.(976-978)AAT>CAT	p.N326H	TTK_uc003pjb.3_Missense_Mutation_p.N326H	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	326					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TGAATTAAGAAATTTAAAGGT	0.358			NA											13	151					0	0	0.003163	0	0
RBAK	57786	broad.mit.edu	37	7	5103663	5103663	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:5103663A>C	uc010kss.1	+	6	900	c.576A>C	c.(574-576)GAA>GAC	p.E192D	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.E192D	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	192	Required for interaction with RB1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		ACAATGAAGAAAATATTCTTC	0.333			NA											3	68					0	0	0.004672	0	0
PCOLCE	5118	broad.mit.edu	37	7	100201142	100201142	+	Missense_Mutation	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:100201142A>G	uc003uvo.2	+	2	383	c.185A>G	c.(184-186)GAG>GGG	p.E62G	uc011kjy.1_Intron|PCOLCE_uc011kkb.1_Missense_Mutation_p.E62G|PCOLCE_uc010lhb.1_RNA|PCOLCE_uc003uvp.1_5'Flank	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	62	CUB 1.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCTAATAAGGAGTGCATCTGG	0.577			NA											14	17					0	0	0.001855	0	0
MUC17	140453	broad.mit.edu	37	7	100678181	100678181	+	Silent	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:100678181T>C	uc003uxp.1	+	3	3537	c.3484T>C	c.(3484-3486)TTA>CTA	p.L1162L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1162	Extracellular (Potential).|59 X approximate tandem repeats.|17.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACCACTCCGTTAGCAAGTAT	0.517			NA											82	180					0	0	0.00361	0	0
RELN	5649	broad.mit.edu	37	7	103202292	103202292	+	Silent	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:103202292T>G	uc003vca.2	-	35	5479	c.5319A>C	c.(5317-5319)TCA>TCC	p.S1773S	RELN_uc010liz.2_Silent_p.S1773S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1773	EGF-like 4.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCCTCGTCCTGAGCACATCC	0.473	NSCLC(146;835 1944 15585 22231 52158)		NA											15	29					0	0	0.00499	0	0
MLL5	55904	broad.mit.edu	37	7	104749673	104749673	+	Silent	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:104749673A>G	uc003vcm.2	+	23	4287	c.3753A>G	c.(3751-3753)CAA>CAG	p.Q1251Q	MLL5_uc010ljc.2_Silent_p.Q1251Q|MLL5_uc010lje.1_RNA|MLL5_uc010ljf.1_RNA|MLL5_uc010ljg.2_Missense_Mutation_p.N57S|uc003vcp.1_5'Flank|MLL5_uc010ljh.1_Missense_Mutation_p.N57S	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1251					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CAGAAGTTCAATGGTAAGCCC	0.398			NA											8	13					0	0	0.004482	0	0
PNPLA8	50640	broad.mit.edu	37	7	108137971	108137971	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:108137971T>G	uc003vff.1	-	7	1816	c.1409A>C	c.(1408-1410)AAG>ACG	p.K470T	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.K470T|PNPLA8_uc003vfi.1_Missense_Mutation_p.K370T|PNPLA8_uc003vfj.1_Missense_Mutation_p.K470T|PNPLA8_uc003vfk.1_Missense_Mutation_p.K370T	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	470	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						ATGAACTGGCTTCTGAGTAAG	0.363			NA											9	44					0	0	0.006214	0	0
SSPO	23145	broad.mit.edu	37	7	149492740	149492740	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr7:149492740T>G	uc010lpk.2	+	44	6520	c.6520T>G	c.(6520-6522)TTG>GTG	p.L2174V		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2174	F5/8 type C.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCTGGCATCTTGCCCCTGCC	0.592			NA											63	111					0	0	0.00361	0	0
TUSC3	7991	broad.mit.edu	37	8	15508234	15508234	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr8:15508234G>T	uc003wwt.2	+	3	547	c.337G>T	c.(337-339)GCG>TCG	p.A113S	TUSC3_uc003wwr.2_Missense_Mutation_p.A113S|TUSC3_uc003wws.2_Missense_Mutation_p.A113S|TUSC3_uc003wwu.2_Missense_Mutation_p.A113S|TUSC3_uc003wwv.2_Missense_Mutation_p.A113S|TUSC3_uc003www.2_Missense_Mutation_p.A113S|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.A113S	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	113					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		TCAAATACTGGCGAACTCCTG	0.393			NA											56	128					2.47907e-22	2.66086e-22	0.00361	1	0
MTMR7	9108	broad.mit.edu	37	8	17188790	17188790	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr8:17188790A>C	uc003wxm.2	-	7	973	c.734T>G	c.(733-735)CTT>CGT	p.L245R	MTMR7_uc003wxn.2_Missense_Mutation_p.L24R	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	245	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CATTGCATTAAGCTGCAGTGG	0.378			NA											22	29					0	0	0.001882	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20062036	20062036	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr8:20062036T>G	uc003wzp.2	+	2	392	c.178T>G	c.(178-180)TTA>GTA	p.L60V		NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	60					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		ACTAGTGATCTTAGATCATGT	0.313	Pancreas(119;1230 1726 3901 4036 31644)		NA											14	55					0	0	0.007413	0	0
UBR5	51366	broad.mit.edu	37	8	103324705	103324705	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr8:103324705T>G	uc003ykr.1	-	17	2049	c.2016A>C	c.(2014-2016)AAA>AAC	p.K672N	UBR5_uc003yks.1_Missense_Mutation_p.K672N	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	672					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CACCATCTACTTTTAGCACCT	0.368	Ovarian(131;96 1741 5634 7352 27489)		NA											35	73					0	0	0.002522	0	0
GALNT12	79695	broad.mit.edu	37	9	101594148	101594148	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr9:101594148A>C	uc004ayz.2	+	4	826	c.826A>C	c.(826-828)ATC>CTC	p.I276L		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	276	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				GGAGCCCCAGATCGGCGGTTT	0.577			NA											7	13					0	0	0.00308	0	0
ASB6	140459	broad.mit.edu	37	9	132402830	132402830	+	Silent	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr9:132402830G>A	uc004byf.1	-	2	451	c.285C>T	c.(283-285)CTC>CTT	p.L95L	ASB6_uc004bye.1_Silent_p.L20L|ASB6_uc004byg.1_Silent_p.L95L|ASB6_uc011mbt.1_Intron|ASB6_uc010myx.1_Silent_p.L95L	NM_017873	NP_060343	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box-containing 6 isoform	95	ANK 1.				intracellular signal transduction	cytoplasm					0		Ovarian(14;0.00556)				CTTCAAAGTTGAGATTGGCCC	0.652			NA											12	19					0	0	0.003163	0	0
FUT7	2529	broad.mit.edu	37	9	139925457	139925457	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr9:139925457G>A	uc004ckq.2	-	2	1583	c.734C>T	c.(733-735)GCA>GTA	p.A245V	ABCA2_uc011mel.1_5'Flank|ABCA2_uc011mem.1_5'Flank|ABCA2_uc004ckl.1_5'Flank|ABCA2_uc004ckm.1_5'Flank|C9orf139_uc004ckp.1_Intron	NM_004479	NP_004470	Q11130	FUT7_HUMAN	fucosyltransferase 7	245	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		AGCCACCAGTGCGTTGCGCCA	0.627			NA											34	87					0	0	0.003271	0	0
CACNA1B	774	broad.mit.edu	37	9	140811791	140811791	+	Missense_Mutation	SNP	T	T	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr9:140811791T>G	uc004cog.2	+	6	1019	c.874T>G	c.(874-876)TTT>GTT	p.F292V		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	292	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGGACCCAACTTTGGCATCAC	0.582			NA											14	62					0	0	0.001855	0	0
BCOR	54880	broad.mit.edu	37	X	39921444	39921444	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chrX:39921444T>C	uc004den.3	-	10	4668	c.4376A>G	c.(4375-4377)AAT>AGT	p.N1459S	BCOR_uc004dep.3_Missense_Mutation_p.N1425S|BCOR_uc004deo.3_Missense_Mutation_p.N1407S|BCOR_uc010nhb.2_Missense_Mutation_p.N167S|BCOR_uc004dem.3_Missense_Mutation_p.N1425S	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1459				N -> S (in Ref. 6; BAA91061).	heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						AGCGTTCTTATTGACAATAAG	0.647			NA											7	14					0	0	0.001984	0	0
ZXDA	7789	broad.mit.edu	37	X	57935082	57935082	+	Silent	SNP	G	G	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chrX:57935082G>T	uc004dve.2	-	1	1986	c.1773C>A	c.(1771-1773)ACC>ACA	p.T591T		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	591	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GTCTCTGGCTGGTAAGTTCAC	0.473			NA											24	75					2.79863e-10	2.94497e-10	0.004656	1	0
ATRX	546	broad.mit.edu	37	X	76872168	76872168	+	Silent	SNP	A	A	G			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chrX:76872168A>G	uc004ecp.3	-	22	5711	c.5479T>C	c.(5479-5481)TTG>CTG	p.L1827L	ATRX_uc004ecq.3_Silent_p.L1789L|ATRX_uc004eco.3_Silent_p.L1612L	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1827					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTGGAGGCAAGAATTTTGTT	0.313			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						5	79					0	0	0.000602	0	0
UTP14A	10813	broad.mit.edu	37	X	129059058	129059058	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chrX:129059058C>T	uc004euz.2	+	12	1664	c.1636C>T	c.(1636-1638)CCT>TCT	p.P546S	UTP14A_uc011mup.1_Missense_Mutation_p.P494S|UTP14A_uc011muq.1_Missense_Mutation_p.P492S	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	546					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						AAATAATCGCCCTGATGCCCC	0.478			NA											19	97					0	0	0.010504	0	0
RENBP	5973	broad.mit.edu	37	X	153209152	153209152	+	Missense_Mutation	SNP	C	C	A	rs34430440	byFrequency	TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chrX:153209152C>A	uc004fjo.1	-	5	478	c.308G>T	c.(307-309)CGG>CTG	p.R103L	RENBP_uc011mzh.1_Missense_Mutation_p.R103L	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	103					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	CCGGGCATACCGCAGCAAGAA	0.632			NA											23	53					1.1804e-14	1.25857e-14	0.003954	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr1:74575212_74575213insT	uc001dfy.3	-	5	924_925	c.732_733insA	c.(730-735)AAACAGfs	p.K244fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	244_245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						ovary(2)	2						TTTTCCTGCTGTTTTTTTTTGT	0.327			NA											8	90	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	16	18441114	18441116	+	Splice_Site	DEL	CAC	CAC	-			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	CAC	CAC	-	-	CAC	CAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr16:18441114_18441116delCAC	uc010bvw.2	-	7	1784	c.1128_splice	c.e7+1	p.V376_splice						SubName: Full=cDNA FLJ59085, highly similar to Polycystin-1;												NA						CGGCCATACTCACCACTGGGACT	0.709			NA											6	13	---	---	---	---	NA	NA	NA	NA	NA
AKAP8L	26993	broad.mit.edu	37	19	15491175	15491175	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr19:15491175delG	uc002naw.1	-	14	1798	c.1699delC	c.(1699-1701)CTGfs	p.L567fs	AKAP8_uc002nav.2_5'Flank|AKAP8_uc010xog.1_5'Flank|AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Frame_Shift_Del_p.L506fs	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	567				EEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPE PA -> RRRRSRRRLRAVPWTRGRRAKRQGFRRAQRACRRS LPCPQSQP (in Ref. 3; AAF86048).		cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CCCTCGTCCAGGGCACCGCCC	0.741			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
CCDC108	255101	broad.mit.edu	37	2	219900304	219900305	+	In_Frame_Ins	INS	-	-	CCT			TCGA-67-6215-01A-11D-1753-08	TCGA-67-6215-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	68c2a355-862c-4657-b296-5776ed8447b0	1d5b64bd-f901-4f03-95c8-db234cd459fd	g.chr2:219900304_219900305insCCT	uc002vjl.1	-	5	523_524	c.439_440insAGG	c.(439-441)GTG>GAGGTG	p.146_147insE	CCDC108_uc010zkp.1_In_Frame_Ins_p.135_136insE|CCDC108_uc010zkq.1_In_Frame_Ins_p.81_82insE|CCDC108_uc002vjn.2_In_Frame_Ins_p.81_82insE	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	146_147						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCCTCAGCCACCTCAATGCCC	0.525			NA											40	93	---	---	---	---	NA	NA	NA	NA	NA
