Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf127	148345	broad.mit.edu	37	1	11008207	11008207	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:11008207G>A	uc010oao.1	-	8	1543	c.1538C>T	c.(1537-1539)GCG>GTG	p.A513V	C1orf127_uc001arr.1_Missense_Mutation_p.A495V|C1orf127_uc001ars.1_Missense_Mutation_p.A487V	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	513										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GGCATCCCTCGCTGGCAGGAT	0.647			NA											13	58					0	0	0.00245	0	0
INSRR	3645	broad.mit.edu	37	1	156816537	156816537	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:156816537G>A	uc010pht.1	-	8	1838	c.1584C>T	c.(1582-1584)AAC>AAT	p.N528N	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	528	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTCTGTGGCGTTCTGGAATG	0.617			NA											6	41					0	0	0.001168	0	0
MR1	3140	broad.mit.edu	37	1	181019198	181019198	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:181019198G>A	uc001goq.1	+	3	385	c.380G>A	c.(379-381)AGC>AAC	p.S127N	MR1_uc001gop.2_Missense_Mutation_p.S127N|MR1_uc001gor.1_Intron|MR1_uc001gos.1_Missense_Mutation_p.S127N|MR1_uc010pns.1_Missense_Mutation_p.S127N	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	127	Extracellular (Potential).|Ligand-binding.|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						GAGGATGGAAGCACCACAGGA	0.522	Colon(174;1412 1962 45296 46549 47110)		NA											3	86					0	0	0.004672	0	0
LIN9	286826	broad.mit.edu	37	1	226421197	226421197	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:226421197C>T	uc001hqa.2	-	13	1631	c.1321G>A	c.(1321-1323)GCA>ACA	p.A441T	LIN9_uc001hqb.2_Missense_Mutation_p.A406T|LIN9_uc001hqc.2_Missense_Mutation_p.A373T|LIN9_uc009xel.1_Missense_Mutation_p.A406T	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	425					cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GGCTGATCTGCAGGCTGGAGC	0.483	Ovarian(197;1696 2974 11248 14117)		NA											16	97					0	0	0.003163	0	0
ZNF488	118738	broad.mit.edu	37	10	48371096	48371096	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:48371096C>T	uc001jex.2	+	2	726	c.564C>T	c.(562-564)GCC>GCT	p.A188A	ZNF488_uc001jey.2_Silent_p.A81A	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGCAGATGCCCTGGGGGAGC	0.537			NA											8	58					0	0	0.004482	0	0
UNC5B	219699	broad.mit.edu	37	10	73051404	73051404	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:73051404G>T	uc001jro.2	+	10	1955	c.1510G>T	c.(1510-1512)GGG>TGG	p.G504W	UNC5B_uc001jrp.2_Missense_Mutation_p.G493W	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	504	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						TGACCTGCTGGGGGTCTTGCC	0.657			NA											28	85					5.61819e-17	7.59381e-17	0.005443	1	0
ECD	11319	broad.mit.edu	37	10	74899220	74899220	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:74899220A>G	uc001jtn.2	-	11	1511	c.1268T>C	c.(1267-1269)CTG>CCG	p.L423P	ECD_uc009xqx.2_Missense_Mutation_p.L456P|ECD_uc009xqy.2_Missense_Mutation_p.L380P|ECD_uc001jto.2_Missense_Mutation_p.L122P	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	423					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					CAGCTGGTCCAGCTGATCTGG	0.453			NA											15	56					0	0	0.00499	0	0
PI4K2A	55361	broad.mit.edu	37	10	99400513	99400513	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:99400513G>A	uc001kog.1	+	1	71	c.14G>A	c.(13-15)AGC>AAC	p.S5N	PI4K2A_uc010qoy.1_Intron	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	5					phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		GACGAGACGAGCCCACTAGTG	0.736			NA											6	42					0	0	0.004482	0	0
MUC5B	727897	broad.mit.edu	37	11	1272788	1272788	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:1272788C>T	uc009ycr.1	+	52	15770	c.15644C>T	c.(15643-15645)ACG>ATG	p.T5215M	MUC5B_uc001ltb.2_Missense_Mutation_p.T4896M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4893	Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTGCCTCCACGGTTCCCAGC	0.662			NA											4	27					0	0	0.000602	0	0
PDE3B	5140	broad.mit.edu	37	11	14666460	14666460	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:14666460G>A	uc001mln.2	+	1	1192	c.839G>A	c.(838-840)AGT>AAT	p.S280N	PDE3B_uc001mlm.2_Missense_Mutation_p.S280N|PDE3B_uc010rcr.1_Missense_Mutation_p.S280N|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	280					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						CGACTGTCCAGTGCCGCCGAA	0.587			NA											17	56					0	0	0.006122	0	0
KCNC1	3746	broad.mit.edu	37	11	17757663	17757663	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:17757663G>A	uc001mnk.3	+	1	169	c.114G>A	c.(112-114)GCG>GCA	p.A38A	KCNC1_uc009yhc.1_Silent_p.A38A	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	38	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						CCTGGCTGGCGGAGCCCGACG	0.682			NA											4	18					0	0	0.009096	0	0
INPPL1	3636	broad.mit.edu	37	11	71949338	71949338	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:71949338G>T	uc001osf.2	+	28	3865	c.3718G>T	c.(3718-3720)GGG>TGG	p.G1240W	INPPL1_uc001osg.2_Missense_Mutation_p.G998W	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1240	SAM.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						GGAGGAGGCTGGGGTGCAGGA	0.637			NA									OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	46					2.27111e-07	2.82168e-07	0.013537	1	0
SPCS2	9789	broad.mit.edu	37	11	74676882	74676882	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:74676882C>T	uc001ovu.2	+	3	312	c.273C>T	c.(271-273)TCC>TCT	p.S91S		NM_014752	NP_055567	Q15005	SPCS2_HUMAN	signal peptidase complex subunit 2 homolog	91	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			breast(1)	1						GTACAATCTCCTGTTTCTTTG	0.393			NA											9	52					0	0	0.004482	0	0
CCDC90B	60492	broad.mit.edu	37	11	82972966	82972966	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:82972966C>G	uc001pae.2	-	9	1114	c.752G>C	c.(751-753)AGA>ACA	p.R251T	CCDC90B_uc001pac.2_Missense_Mutation_p.R150T|CCDC90B_uc001pad.2_Missense_Mutation_p.R150T|CCDC90B_uc001paf.2_Missense_Mutation_p.R242T	NM_021825	NP_068597	Q9GZT6	CC90B_HUMAN	coiled-coil domain containing 90B precursor	251	Helical; (Potential).					integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)				CTTCCAGAATCTATAAAATCC	0.388			NA											5	99					0	0	0.000602	0	0
FLI1	2313	broad.mit.edu	37	11	128638032	128638032	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:128638032A>G	uc010sbu.1	+	3	591	c.250A>G	c.(250-252)AGC>GGC	p.S84G	FLI1_uc010sbt.1_Intron|FLI1_uc010sbv.1_Missense_Mutation_p.S51G|FLI1_uc009zci.2_Missense_Mutation_p.S18G|FLI1_uc001qen.2_Missense_Mutation_p.S51G	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	84					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GGTGGACTGCAGCGTTAGCAA	0.572			NA	T	EWSR1	Ewing sarcoma								5	13					0	0	0.001984	0	0
CSRNP2	81566	broad.mit.edu	37	12	51457744	51457744	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr12:51457744A>C	uc001rxu.1	-	5	1715	c.1417T>G	c.(1417-1419)TCA>GCA	p.S473A		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	473					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCCACCTCTGATTTACAGAGG	0.527			NA											23	73					0	0	0.014323	0	0
LRP1	4035	broad.mit.edu	37	12	57605790	57605790	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr12:57605790C>T	uc001snd.2	+	87	13805	c.13339C>T	c.(13339-13341)CGA>TGA	p.R4447*		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4447	Cytoplasmic (Potential).|Interaction with MAFB (By similarity).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTATAAGCGGCGAGTCCAAGG	0.527			NA											8	84					0	0	0.00308	0	0
DNAH10	196385	broad.mit.edu	37	12	124403278	124403278	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr12:124403278G>A	uc001uft.3	+	64	10959	c.10934G>A	c.(10933-10935)CGG>CAG	p.R3645Q		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3645					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GACAGGCTGCGGGATGGCTAC	0.572			NA											7	21					0	0	0.00308	0	0
SACS	26278	broad.mit.edu	37	13	23909353	23909353	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:23909353C>T	uc001uon.2	-	10	9251	c.8662G>A	c.(8662-8664)GCA>ACA	p.A2888T	SACS_uc001uoo.2_Missense_Mutation_p.A2741T|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2888					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAATCCAGTGCAAAGTGGCCA	0.448			NA											5	22					0	0	0.001168	0	0
CENPJ	55835	broad.mit.edu	37	13	25487104	25487104	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:25487104C>G	uc001upt.3	-	2	313	c.60G>C	c.(58-60)TGG>TGC	p.W20C	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	20					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GATTGGTCATCCACTGGGTTA	0.438			NA											6	45					0	0	0.006214	0	0
ATP8A2	51761	broad.mit.edu	37	13	26273402	26273402	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:26273402C>A	uc001uqk.2	+	25	2445	c.2303C>A	c.(2302-2304)ACC>AAC	p.T768N	ATP8A2_uc010tdi.1_Missense_Mutation_p.T728N|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.T318N	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	728	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GATGGCCACACCCTGAAGTAC	0.547			NA											12	53					2.27111e-07	2.82168e-07	0.013537	1	0
ATP7B	540	broad.mit.edu	37	13	52509127	52509127	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:52509127G>A	uc001vfw.2	-	21	4320	c.4163C>T	c.(4162-4164)GCG>GTG	p.A1388V	ATP7B_uc010adv.2_Missense_Mutation_p.A958V|ATP7B_uc001vfx.2_Missense_Mutation_p.A1181V|ATP7B_uc001vfy.2_Missense_Mutation_p.A1277V|ATP7B_uc010tgt.1_Missense_Mutation_p.A1323V|ATP7B_uc010tgu.1_Missense_Mutation_p.A1340V|ATP7B_uc010tgv.1_Missense_Mutation_p.A1310V|ATP7B_uc001vfv.2_Missense_Mutation_p.A660V|ATP7B_uc010tgs.1_Missense_Mutation_p.A599V	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1388	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GTGGCCATGCGCCTGTGCCTC	0.547			NA							Wilson_disease				11	45					0	0	0.013537	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454780	84454780	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:84454780G>T	uc001vlk.2	-	1	1749	c.863C>A	c.(862-864)ACT>AAT	p.T288N		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	288	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTTGAAAGGAGTTGGCAGGGG	0.542			NA											11	43					4.84862e-15	6.34446e-15	0.010729	1	0
ERCC5	2073	broad.mit.edu	37	13	103528149	103528149	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:103528149G>A	uc001vpw.2	+	15	3900	c.3457G>A	c.(3457-3459)GAC>AAC	p.D1153N		NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	1153					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGATAGTGATGACGATGGAGG	0.493			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				13	21					0	0	0.003163	0	0
OXA1L	5018	broad.mit.edu	37	14	23235884	23235884	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:23235884G>A	uc001wgn.2	+	1	154	c.154G>A	c.(154-156)GCA>ACA	p.A52T	OXA1L_uc010tnc.1_Missense_Mutation_p.A52T|OXA1L_uc001wgo.2_RNA|OXA1L_uc010akc.2_Missense_Mutation_p.A52T|OXA1L_uc001wgp.2_5'Flank|OXA1L_uc001wgq.2_5'Flank	NM_005015	NP_005006	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	Error:Variant_position_missing_in_Q15070_after_alignment					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)	1	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		CTGCGCAGGCGCAAAAGCAAG	0.582			NA											14	124					0	0	0.00245	0	0
MYH7	4625	broad.mit.edu	37	14	23902380	23902380	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:23902380T>A	uc001wjx.2	-	4	364	c.258A>T	c.(256-258)AAA>AAT	p.K86N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	86	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTCCTCGATTTTGTCGAACT	0.587			NA											23	99					0	0	0.013726	0	0
ADCY4	196883	broad.mit.edu	37	14	24798353	24798353	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:24798353G>A	uc001wov.2	-	10	1444	c.1438C>T	c.(1438-1440)CGT>TGT	p.R480C	ADCY4_uc001wow.2_Missense_Mutation_p.R480C|ADCY4_uc010toh.1_Missense_Mutation_p.R166C|ADCY4_uc001wox.2_Missense_Mutation_p.R480C|ADCY4_uc001woy.2_Missense_Mutation_p.R480C	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	480	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		TCCAGGTAACGGGTCATCAGC	0.617			NA											9	55					0	0	0.006214	0	0
OR4N4	283694	broad.mit.edu	37	15	22383265	22383265	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:22383265T>A	uc001yuc.1	+	7	1774	c.793T>A	c.(793-795)TTA>ATA	p.L265I	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.L265I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTTCAGGGCCTTACCAGCTGA	0.433			NA											21	255					0	0	0.00278	0	0
LINGO1	84894	broad.mit.edu	37	15	77907402	77907402	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:77907402C>T	uc002bct.1	-	2	899	c.847G>A	c.(847-849)GTC>ATC	p.V283I	LINGO1_uc002bcu.1_Missense_Mutation_p.V277I	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	283	Extracellular (Potential).|LRR 8.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						AGGTGGCGGACGGCCAGGTAG	0.587			NA											3	57					0	0	0.009096	0	0
WASH3P	374666	broad.mit.edu	37	15	102516424	102516424	+	Silent	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:102516424G>T	uc002cdi.2	+	11	2170	c.750G>T	c.(748-750)CCG>CCT	p.P250P	WASH3P_uc002cdl.2_Silent_p.P250P|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Silent_p.P250P|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGCCGCCACCGCAGCAGCCAC	0.647			NA											7	69					0.000157383	0.000179242	0.00308	1	0
TMC5	79838	broad.mit.edu	37	16	19485537	19485537	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr16:19485537A>T	uc002dgc.3	+	12	2778	c.2029A>T	c.(2029-2031)ATG>TTG	p.M677L	TMC5_uc010vaq.1_Missense_Mutation_p.M625L|TMC5_uc002dgb.3_Missense_Mutation_p.M677L|TMC5_uc010var.1_Missense_Mutation_p.M677L|TMC5_uc002dgd.1_Missense_Mutation_p.M431L|TMC5_uc002dge.3_Missense_Mutation_p.M431L|TMC5_uc002dgf.3_Missense_Mutation_p.M360L|TMC5_uc002dgg.3_Missense_Mutation_p.M318L	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	677	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						CATCTACTCCATGTTCAGGCT	0.552			NA											5	158					0	0	0.000602	0	0
SCARF1	8578	broad.mit.edu	37	17	1538814	1538814	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:1538814C>T	uc002fsz.1	-	11	1781	c.1731G>A	c.(1729-1731)CCG>CCA	p.P577P	SCARF1_uc002fsy.1_Missense_Mutation_p.R565H|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Silent_p.P491P	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	577	Pro/Ser-rich.|Cytoplasmic (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity	p.P577S(1)		skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGGAGGTGCGCGGGATGGCGA	0.672			NA											18	74					0	0	0.007413	0	0
DHX8	1659	broad.mit.edu	37	17	41569551	41569551	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:41569551A>T	uc002idu.1	+	5	467	c.394A>T	c.(394-396)ACC>TCC	p.T132S	DHX8_uc010wif.1_Missense_Mutation_p.T41S|DHX8_uc010wig.1_Missense_Mutation_p.T132S	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	132						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACCTCTGCAGACCATGTTGGA	0.443	NSCLC(56;1548 1661 49258 49987)		NA											8	26					0	0	0.006214	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476905	42476905	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:42476905C>A	uc002igw.1	-	8	2604	c.2540G>T	c.(2539-2541)AGT>ATT	p.S847I	GPATCH8_uc002igv.1_Missense_Mutation_p.S769I|GPATCH8_uc010wiz.1_Missense_Mutation_p.S769I	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	847	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GGAATGCTCACTGCCTGAATC	0.552			NA											31	65					5.45727e-16	7.29613e-16	0.008361	1	0
ANKFN1	162282	broad.mit.edu	37	17	54428148	54428148	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:54428148G>A	uc002iun.1	+	4	254	c.219G>A	c.(217-219)ACG>ACA	p.T73T		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	73										large_intestine(1)|ovary(1)	2						TGAAAATGACGCAACAAATGC	0.388			NA											10	44					0	0	0.006214	0	0
CLUL1	27098	broad.mit.edu	37	18	641426	641426	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:641426G>A	uc002kkp.2	+	7	1239	c.1094G>A	c.(1093-1095)CGG>CAG	p.R365Q	CLUL1_uc010wys.1_Missense_Mutation_p.R417Q|CLUL1_uc002kkq.2_Missense_Mutation_p.R365Q	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	365					cell death	extracellular region				ovary(2)	2						CAGATGACCCGGAAGCACTTG	0.522			NA											15	110					0	0	0.003163	0	0
LAMA1	284217	broad.mit.edu	37	18	6956680	6956680	+	Silent	SNP	G	G	A	rs145856205		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:6956680G>A	uc002knm.2	-	56	8143	c.8049C>T	c.(8047-8049)CCC>CCT	p.P2683P	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Silent_p.P136P|LAMA1_uc010wzj.1_Silent_p.P2159P	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2683					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTCTGCATCGGGAGCCAGCT	0.542			NA											6	48					0	0	0.001168	0	0
ZNF521	25925	broad.mit.edu	37	18	22807567	22807567	+	Silent	SNP	G	G	A	rs145068263		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:22807567G>A	uc002kvk.2	-	4	562	c.315C>T	c.(313-315)TGC>TGT	p.C105C	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.C105C|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	105					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CTCCAAAATCGCAACCTTCTC	0.517			NA	T	PAX5	ALL								4	59					0	0	0.009096	0	0
ELP2	55250	broad.mit.edu	37	18	33734899	33734899	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:33734899C>T	uc002kzk.1	+	12	1222	c.1212C>T	c.(1210-1212)ATC>ATT	p.I404I	ELP2_uc010xcg.1_Silent_p.I469I|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Silent_p.I378I|ELP2_uc010xch.1_Silent_p.I399I|ELP2_uc002kzn.1_Silent_p.I334I|ELP2_uc002kzo.1_Silent_p.I334I	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	404	WD 8.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						AATTTATTATCACTGTTGGTA	0.368			NA											7	42					0	0	0.006214	0	0
PRAM1	84106	broad.mit.edu	37	19	8564620	8564620	+	Silent	SNP	G	G	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:8564620G>C	uc002mkd.2	-	2	92	c.72C>G	c.(70-72)GCC>GCG	p.A24A	PRAM1_uc002mkc.2_Silent_p.A24A	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	24							lipid binding|protein binding				0						CCGGCTGAGAGGCCTGGAACT	0.562			NA											5	13					0	0	0.000602	0	0
ZNF91	7644	broad.mit.edu	37	19	23545333	23545333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:23545333G>A	uc002nre.2	-	4	561	c.448C>T	c.(448-450)CAG>TAG	p.Q150*	ZNF91_uc010xrj.1_Nonsense_Mutation_p.Q118*	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	150						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				ACTTTGCTCTGGGCAGTTGTG	0.323			NA											13	37					0	0	0.00245	0	0
ZFP82	284406	broad.mit.edu	37	19	36884215	36884215	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:36884215A>G	uc002ody.1	-	5	1262	c.1027T>C	c.(1027-1029)TGC>CGC	p.C343R		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	343	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GCCTTCCCGCATTCCTTACAT	0.423			NA											9	90					0	0	0.006214	0	0
RYR1	6261	broad.mit.edu	37	19	38979989	38979989	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:38979989A>G	uc002oit.2	+	35	5850	c.5720A>G	c.(5719-5721)GAA>GGA	p.E1907G	RYR1_uc002oiu.2_Missense_Mutation_p.E1907G	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1907	Glu-rich (acidic).|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	gaagatgaggaaaaagaggaa	0.224			NA											13	33					0	0	0.001855	0	0
ZNF285	26974	broad.mit.edu	37	19	44891618	44891618	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:44891618G>A	uc002ozd.3	-	4	876	c.789C>T	c.(787-789)GAC>GAT	p.D263D	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Silent_p.D270D	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	263	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TTCCATACTGGTCACATTTAT	0.433			NA											35	81					0	0	0.003271	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46388248	46388248	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:46388248G>A	uc002pds.1	-	1	1129	c.785C>T	c.(784-786)ACT>ATT	p.T262I		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		AGGACGGGCAGTAGCATCGAA	0.627			NA											3	77					0	0	0.004672	0	0
SIGLEC12	89858	broad.mit.edu	37	19	51994907	51994907	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:51994907G>A	uc002pwx.1	-	8	1832	c.1776C>T	c.(1774-1776)AAC>AAT	p.N592N	SIGLEC12_uc002pww.1_Silent_p.N474N|SIGLEC12_uc010eoy.1_Silent_p.N319N	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	592	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACTTGGGGATGTTGATCTCGG	0.532			NA											32	115					0	0	0.004878	0	0
ZNF613	79898	broad.mit.edu	37	19	52447726	52447726	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:52447726C>A	uc002pxz.1	+	6	1013	c.590C>A	c.(589-591)ACT>AAT	p.T197N	ZNF613_uc002pya.1_Missense_Mutation_p.T161N	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		CATCAGCGAACTCAAAACATA	0.408			NA											52	193					3.4597e-24	4.72826e-24	0.01441	1	0
SRD5A2	6716	broad.mit.edu	37	2	31805965	31805965	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:31805965T>A	uc002rnw.1	-	1	76	c.5A>T	c.(4-6)CAG>CTG	p.Q2L		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	2					androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GCACTGAACCTGCATCGCGCC	0.697			NA											6	35					0	0	0.001168	0	0
DHX57	90957	broad.mit.edu	37	2	39085937	39085937	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:39085937C>A	uc002rrf.2	-	6	1552	c.1453G>T	c.(1453-1455)GGT>TGT	p.G485C	DHX57_uc002rre.2_5'UTR|DHX57_uc002rrg.2_Missense_Mutation_p.G485C	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	485							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				GGTGCAGGACCGTCATCCTCA	0.378	Melanoma(191;1090 2095 4375 23729 47341)		NA											12	31					2.27111e-07	2.82168e-07	0.013537	1	0
GPR45	11250	broad.mit.edu	37	2	105858611	105858611	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:105858611G>A	uc002tco.1	+	1	412	c.296G>A	c.(295-297)CGC>CAC	p.R99H		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	99	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						ATCACCGTGCGCTGGCACTTT	0.632			NA											33	140					0	0	0.004289	0	0
LRP1B	53353	broad.mit.edu	37	2	141291668	141291668	+	Missense_Mutation	SNP	G	G	T	rs151047433		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:141291668G>T	uc002tvj.1	-	47	8656	c.7684C>A	c.(7684-7686)CGC>AGC	p.R2562S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2562	Extracellular (Potential).|LDL-receptor class A 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.R2562C(1)		lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGCAGCGGCGATTATAGCAT	0.363	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			6	31					5.9392e-07	7.23289e-07	0.001168	1	0
LRP2	4036	broad.mit.edu	37	2	170101363	170101363	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:170101363G>A	uc002ues.2	-	22	3483	c.3270C>T	c.(3268-3270)AAC>AAT	p.N1090N	LRP2_uc010zdf.1_Silent_p.N953N	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1090	LDL-receptor class A 9.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCACACAGTCGTTGCGTTTGT	0.512			NA											31	134					0	0	0.013726	0	0
ZMYND8	23613	broad.mit.edu	37	20	45875019	45875019	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr20:45875019G>C	uc002xta.1	-	14	2211	c.1957C>G	c.(1957-1959)CCA>GCA	p.P653A	ZMYND8_uc010ghq.1_Missense_Mutation_p.P330A|ZMYND8_uc010ghr.1_Missense_Mutation_p.P628A|ZMYND8_uc002xst.1_Missense_Mutation_p.P581A|ZMYND8_uc002xsu.1_Missense_Mutation_p.P653A|ZMYND8_uc002xsv.1_Missense_Mutation_p.P581A|ZMYND8_uc002xsw.1_Missense_Mutation_p.P405A|ZMYND8_uc002xsx.1_Missense_Mutation_p.P405A|ZMYND8_uc002xsy.1_Missense_Mutation_p.P628A|ZMYND8_uc002xsz.1_Missense_Mutation_p.P590A|ZMYND8_uc010zxy.1_Missense_Mutation_p.P680A|ZMYND8_uc002xtb.1_Missense_Mutation_p.P673A|ZMYND8_uc002xss.2_Missense_Mutation_p.P653A|ZMYND8_uc010zxz.1_Missense_Mutation_p.P648A|ZMYND8_uc002xtc.1_Missense_Mutation_p.P673A|ZMYND8_uc002xtd.1_Missense_Mutation_p.P648A|ZMYND8_uc002xte.1_Missense_Mutation_p.P653A|ZMYND8_uc010zya.1_Missense_Mutation_p.P653A|ZMYND8_uc002xtf.1_Missense_Mutation_p.P673A|ZMYND8_uc002xtg.2_Missense_Mutation_p.P647A|ZMYND8_uc010ghs.1_Missense_Mutation_p.P647A	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	653							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCGCTGGCTGGTGACGTGCTT	0.507			NA											24	83					0	0	0.004656	0	0
SCN11A	11280	broad.mit.edu	37	3	38988324	38988324	+	Silent	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:38988324A>G	uc011ays.1	-	2	541	c.342T>C	c.(340-342)CCT>CCC	p.P114P		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	114					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTGAATTGAAAGGCCCAAAAA	0.383			NA											4	65					0	0	0.009096	0	0
ZNF619	285267	broad.mit.edu	37	3	40528959	40528959	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:40528959G>T	uc011azb.1	+	6	1356	c.1078G>T	c.(1078-1080)GAA>TAA	p.E360*	ZNF619_uc010hhz.2_Nonsense_Mutation_p.E311*|ZNF619_uc003ckj.2_Nonsense_Mutation_p.E304*|ZNF619_uc011azc.1_Nonsense_Mutation_p.E320*|ZNF619_uc011azd.1_Nonsense_Mutation_p.E276*|ZNF619_uc011aza.1_Nonsense_Mutation_p.E262*	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	360					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TAAATGTAAGGAATGTGGGAA	0.423			NA											16	33					5.01169e-05	5.87084e-05	0.00499	1	0
CXCR6	10663	broad.mit.edu	37	3	45988860	45988860	+	Missense_Mutation	SNP	G	G	A	rs141955108		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:45988860G>A	uc003cpc.1	+	2	968	c.887G>A	c.(886-888)CGA>CAA	p.R296Q	FYCO1_uc003cpb.3_Intron|FYCO1_uc011bal.1_Intron|CXCR6_uc010hix.1_Missense_Mutation_p.R296Q	NM_006564	NP_006555	O00574	CXCR6_HUMAN	G protein-coupled receptor TYMSTR	296	Cytoplasmic (Potential).				viral genome replication	integral to plasma membrane	coreceptor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CTGAAGTTTCGAAAGAACTTC	0.473	Esophageal Squamous(63;1005 1117 15521 45762 47089)		NA											5	39					0	0	0.001168	0	0
STAB1	23166	broad.mit.edu	37	3	52556586	52556586	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:52556586T>A	uc003dej.2	+	61	6700	c.6626T>A	c.(6625-6627)GTT>GAT	p.V2209D	STAB1_uc003dek.1_Missense_Mutation_p.V224D|STAB1_uc003del.2_Missense_Mutation_p.V96D	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2209	Extracellular (Potential).|Link.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGGGCTGGCGTTTTCCACCTC	0.612			NA											3	93					0	0	0.004672	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125828895	125828895	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:125828895C>T	uc003eim.1	-	20	2429	c.2239G>A	c.(2239-2241)GGG>AGG	p.G747R	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.G646R|ALDH1L1_uc003ein.1_Missense_Mutation_p.G282R	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	747	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TTCTGCGGCCCGTGGTCGGTG	0.607			NA											25	45					0	0	0.00632	0	0
LRCH3	84859	broad.mit.edu	37	3	197518157	197518157	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:197518157C>T	uc011bul.1	+	1	13	c.8C>T	c.(7-9)GCC>GTC	p.A3V	LRCH3_uc003fyj.1_Missense_Mutation_p.A3V|LRCH3_uc011bum.1_Missense_Mutation_p.A3V|LRCH3_uc011bun.1_Missense_Mutation_p.A3V	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	3						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		GAAATGGCGGCCGCGGGCTTG	0.716			NA											6	9					0	0	0.004482	0	0
KDR	3791	broad.mit.edu	37	4	55981108	55981109	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:55981108_55981109CA>AT	uc003has.2	-	5	892_893	c.590_591TG>AT	c.(589-591)ATG>AAT	p.M197N	KDR_uc003hat.1_Missense_Mutation_p.M197N|KDR_uc011bzx.1_Missense_Mutation_p.M197N	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	197	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACAGAAGACCATGCCAGCATA	0.381			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			3	27					0	0	0.004672	0	0
FAT4	79633	broad.mit.edu	37	4	126372162	126372162	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:126372162G>T	uc003ifj.3	+	9	9991	c.9991G>T	c.(9991-9993)GGG>TGG	p.G3331W	FAT4_uc011cgp.1_Missense_Mutation_p.G1629W|FAT4_uc003ifi.1_Missense_Mutation_p.G809W	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3331	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGGCACTGATGGGGAGGTACA	0.383			NA											8	57					3.09899e-07	3.81175e-07	0.004482	1	0
GLRB	2743	broad.mit.edu	37	4	158060005	158060005	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:158060005G>T	uc003ipj.2	+	7	857	c.655G>T	c.(655-657)GAT>TAT	p.D219Y		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	219	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GCAGTCAGGAGATCCTGTGCA	0.274			NA											8	37					1.58986e-06	1.91719e-06	0.008291	1	0
CPE	1363	broad.mit.edu	37	4	166408697	166408698	+	Missense_Mutation	DNP	AA	AA	TT			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	AA	AA	-	-	AA	AA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:166408697_166408698AA>TT	uc003irg.3	+	6	1358_1359	c.1081_1082AA>TT	c.(1081-1083)AAC>TTC	p.N361F		NM_001873	NP_001864	P16870	CBPE_HUMAN	carboxypeptidase E preproprotein	361					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGGGAGGATAACAAAAACTCC	0.441			NA											3	32					0	0	0.004672	0	0
PCDHB15	56121	broad.mit.edu	37	5	140627195	140627195	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:140627195C>T	uc003lje.2	+	1	2049	c.2049C>T	c.(2047-2049)GCC>GCT	p.A683A		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	683	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGCCCAGGCCGACTCGCTTA	0.672			NA											46	132					0	0	0.013114	0	0
C5orf54	63920	broad.mit.edu	37	5	159822295	159822295	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:159822295T>A	uc003lye.1	-	2	667	c.203A>T	c.(202-204)CAT>CTT	p.H68L	C5orf54_uc003lyf.1_Missense_Mutation_p.H68L	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	68										pancreas(1)	1						tgctggcatatgcttcaggct	0			NA											16	99					0	0	0.00499	0	0
THOC3	84321	broad.mit.edu	37	5	175387036	175387036	+	Missense_Mutation	SNP	C	C	A	rs139761351		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:175387036C>A	uc003mdg.3	-	6	1326	c.992G>T	c.(991-993)GGC>GTC	p.G331V		NM_032361	NP_115737	Q96J01	THOC3_HUMAN	THO complex 3	331					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	transcription export complex	RNA binding				0	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		GTCATATTTGCCGTCTTTGTC	0.557			NA											4	31					0.000219431	0.000247615	0.00245	1	0
ZNF354B	117608	broad.mit.edu	37	5	178310482	178310482	+	Silent	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:178310482A>G	uc003mjl.2	+	5	1255	c.1029A>G	c.(1027-1029)GGA>GGG	p.G343G	ZNF354B_uc003mjm.2_Silent_p.G343G	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTTTCTGGAAGTCAGAAAA	0.398			NA											11	38					0	0	0.010729	0	0
ATXN1	6310	broad.mit.edu	37	6	16328069	16328069	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:16328069G>T	uc003nbt.2	-	8	1444	c.473C>A	c.(472-474)GCA>GAA	p.A158E	ATXN1_uc010jpi.2_Missense_Mutation_p.A158E|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	158					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CGAGGCCACTGCACTGGTGAC	0.627			NA											34	115					1.90571e-15	2.52045e-15	0.004289	1	0
HIST1H2AK	8330	broad.mit.edu	37	6	27806013	27806013	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:27806013G>A	uc003njs.2	-	1	105	c.105C>T	c.(103-105)CTC>CTT	p.L35L	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	35					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						TGCCCTTGCGGAGCAGTCGGT	0.662			NA											6	60					0	0	0.001168	0	0
SCAND3	114821	broad.mit.edu	37	6	28542473	28542473	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:28542473T>G	uc003nlo.2	-	3	2627	c.2009A>C	c.(2008-2010)AAA>ACA	p.K670T		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	670					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTTAGCATTTTGGAAGGTTT	0.423			NA											17	121					0	0	0.006122	0	0
ZBTB9	221504	broad.mit.edu	37	6	33424182	33424182	+	Silent	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:33424182A>T	uc003oeq.2	+	2	1573	c.1305A>T	c.(1303-1305)GGA>GGT	p.G435G		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCATGCTGGAGCCCTGCATG	0.607			NA											14	100					0	0	0.004007	0	0
VEGFA	7422	broad.mit.edu	37	6	43745332	43745332	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:43745332G>T	uc003owc.2	+	3	1276	c.245G>T	c.(244-246)CGA>CTA	p.R82L	VEGFA_uc003owb.2_Missense_Mutation_p.R82L|VEGFA_uc003owd.2_Missense_Mutation_p.R262L|VEGFA_uc003owf.2_Missense_Mutation_p.R262L|VEGFA_uc003owe.2_Missense_Mutation_p.R262L|VEGFA_uc003owg.2_Missense_Mutation_p.R262L|VEGFA_uc003owh.2_Missense_Mutation_p.R262L|VEGFA_uc003owi.2_Missense_Mutation_p.R262L|VEGFA_uc003owj.2_Missense_Mutation_p.R262L|VEGFA_uc010jyx.2_Missense_Mutation_p.R82L|VEGFA_uc003owk.2_5'Flank	NM_001025370	NP_001020541	P15692	VEGFA_HUMAN	vascular endothelial growth factor A isoform f	82					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			ovary(1)|breast(1)	2	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	CCCCTGATGCGATGCGGGGGC	0.587			NA											18	59					1.33834e-09	1.71474e-09	0.007413	1	0
OPN5	221391	broad.mit.edu	37	6	47749807	47749807	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:47749807C>T	uc003ozc.2	+	1	10	c.5C>T	c.(4-6)GCG>GTG	p.A2V		NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	2	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						AACAGAATGGCGTTAAATCAC	0.498	Melanoma(28;740 973 10870 42660 45347)		NA											11	71					0	0	0.001855	0	0
EYS	346007	broad.mit.edu	37	6	66205100	66205100	+	Silent	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:66205100A>T	uc011dxu.1	-	4	742	c.204T>A	c.(202-204)ACT>ACA	p.T68T	EYS_uc003peq.2_Silent_p.T68T|EYS_uc003per.1_Silent_p.T68T|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	68					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GATTGCCTGAAGTATCTATTT	0.368			NA											8	80					0	0	0.004482	0	0
SYNE1	23345	broad.mit.edu	37	6	152623099	152623099	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:152623099G>A	uc010kiw.2	-	92	18048	c.17446C>T	c.(17446-17448)CTG>TTG	p.L5816L	SYNE1_uc010kiv.2_Silent_p.L340L|SYNE1_uc003qos.3_Silent_p.L340L|SYNE1_uc003qot.3_Silent_p.L5745L|SYNE1_uc003qou.3_Silent_p.L5816L|SYNE1_uc010kiy.1_Silent_p.L38L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5816	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTCACCGTCAGCAGCATGGTG	0.597			NA								HNSCC(10;0.0054)			15	28					0	0	0.00499	0	0
GNA12	2768	broad.mit.edu	37	7	2834581	2834581	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:2834581C>T	uc003smu.2	-	2	670	c.506G>A	c.(505-507)CGG>CAG	p.R169Q	GNA12_uc011jwb.1_Missense_Mutation_p.R169Q|GNA12_uc003smt.2_Missense_Mutation_p.R110Q	NM_007353	NP_031379	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein)	169					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		CTCGCTTCTCCGGCTGAAAGC	0.552			NA											4	99					0	0	0.000602	0	0
CAMK2B	816	broad.mit.edu	37	7	44268445	44268445	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:44268445C>G	uc003tkq.2	-	19	1628	c.1418G>C	c.(1417-1419)GGG>GCG	p.G473A	CAMK2B_uc003tkp.2_Intron|CAMK2B_uc003tkx.2_Intron|CAMK2B_uc010kyd.2_Intron|CAMK2B_uc003tkr.2_Intron|CAMK2B_uc003tks.2_Intron|CAMK2B_uc003tku.2_Intron|CAMK2B_uc003tkv.2_Intron|CAMK2B_uc003tkt.2_Intron|CAMK2B_uc003tkw.2_Intron|CAMK2B_uc010kyc.2_Intron|CAMK2B_uc003tkn.2_Missense_Mutation_p.G106A	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	473					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						GGGCGGGGGCCCCGCTGAGAG	0.677			NA											5	0					0	0	0.000602	0	0
STYXL1	51657	broad.mit.edu	37	7	75634594	75634594	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:75634594G>A	uc003uej.3	-	6	755	c.582C>T	c.(580-582)TCC>TCT	p.S194S	STYXL1_uc003uef.2_5'UTR|STYXL1_uc011kgf.1_Silent_p.S56S|STYXL1_uc011kgg.1_Silent_p.S46S|STYXL1_uc003ueh.2_Silent_p.S56S|STYXL1_uc003uek.3_Silent_p.S98S|STYXL1_uc003uel.2_Silent_p.S194S|STYXL1_uc003uem.2_Silent_p.S194S|STYXL1_uc010ldg.1_RNA|STYXL1_uc010ldh.1_Silent_p.S194S|STYXL1_uc003uen.1_Silent_p.S194S	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	194	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						CTGTATCCATGGAGACATTGA	0.313			NA											6	23					0	0	0.00308	0	0
ARPC1B	10095	broad.mit.edu	37	7	98984357	98984357	+	Silent	SNP	C	C	T	rs144704984		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:98984357C>T	uc003upz.2	+	3	203	c.114C>T	c.(112-114)AGC>AGT	p.S38S	ARPC1A_uc011kit.1_RNA|ARPC1B_uc003uqa.2_Silent_p.S38S|ARPC1B_uc003uqb.2_Silent_p.S38S|ARPC1B_uc003uqc.2_Silent_p.S38S	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	38	WD 1.				cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			ATGAAAAGAGCGGTGCCAAAT	0.572			NA											19	146					0	0	0.014323	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558434	113558434	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:113558434C>A	uc010ljy.1	-	1	649	c.618G>T	c.(616-618)GAG>GAT	p.E206D		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	206	CBM21.				glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GTATACAAAACTCAACTTTAC	0.343			NA											4	19					0.00024832	0.000277667	0.009096	1	0
FAM49B	51571	broad.mit.edu	37	8	130883703	130883703	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr8:130883703T>C	uc003yss.2	-	7	662	c.113A>G	c.(112-114)CAG>CGG	p.Q38R	FAM49B_uc003yst.2_Missense_Mutation_p.Q38R|FAM49B_uc003ysu.2_Missense_Mutation_p.Q38R|FAM49B_uc003ysv.2_5'UTR|FAM49B_uc003ysw.2_Missense_Mutation_p.Q38R|FAM49B_uc003ysx.2_Missense_Mutation_p.Q38R|FAM49B_uc003ysy.1_Missense_Mutation_p.Q38R	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	38											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TACATTCACCTGATTATAAAT	0.388			NA											4	45					0	0	0.000602	0	0
FREM1	158326	broad.mit.edu	37	9	14848737	14848737	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:14848737C>A	uc003zlm.2	-	7	1777	c.1187G>T	c.(1186-1188)AGG>ATG	p.R396M	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	396	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AGGTGCACTCCTTTCAAAGAA	0.438			NA											6	29					8.12818e-05	9.34361e-05	0.001984	1	0
TLE4	7091	broad.mit.edu	37	9	82323092	82323092	+	Silent	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:82323092G>T	uc004ald.2	+	13	1920	c.1071G>T	c.(1069-1071)GCG>GCT	p.A357A	TLE4_uc004alc.2_Silent_p.A332A|TLE4_uc010mpr.2_Silent_p.A211A|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Silent_p.A300A|TLE4_uc010mps.2_Silent_p.A256A|TLE4_uc004alf.2_Silent_p.A271A	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						GAACTGATGCGCCCACCCCAG	0.438			NA											12	75					5.50884e-06	6.57851e-06	0.013537	1	0
PBX3	5090	broad.mit.edu	37	9	128724493	128724493	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:128724493G>A	uc004bqb.2	+	7	1238	c.1122G>A	c.(1120-1122)CAG>CAA	p.Q374Q	PBX3_uc004bqc.2_Silent_p.Q193Q|PBX3_uc004bqd.2_Intron|PBX3_uc011lzw.1_Silent_p.Q299Q|PBX3_uc011lzx.1_Intron|PBX3_uc004bqe.2_Silent_p.Q282Q	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	374					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						TGCAATCACAGGTAGGAGAAA	0.507			NA											4	22					0	0	0.009096	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071110	141071110	+	Silent	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:141071110A>G	uc004com.2	+	4	774	c.513A>G	c.(511-513)CCA>CCG	p.P171P	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGCGCTTCCCAGGCCAGCTGA	0.597			NA											4	52					0	0	0.000602	0	0
MSL3	10943	broad.mit.edu	37	X	11793130	11793130	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:11793130C>T	uc004cuw.2	+	13	1603	c.1498C>T	c.(1498-1500)CCA>TCA	p.P500S	MSL3_uc004cux.2_Missense_Mutation_p.P441S|MSL3_uc011mig.1_Missense_Mutation_p.P351S|MSL3_uc011mih.1_Missense_Mutation_p.P488S|MSL3_uc004cuy.2_Missense_Mutation_p.P334S	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	500					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGACTTCTTCCCAGAGTCGGC	0.423			NA											3	38					0	0	0.009096	0	0
USP9X	8239	broad.mit.edu	37	X	41077680	41077680	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:41077680G>T	uc004dfb.2	+	37	6898	c.6265G>T	c.(6265-6267)GCT>TCT	p.A2089S	USP9X_uc004dfc.2_Missense_Mutation_p.A2089S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2089					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTTTTGGTTTGCTCATAACGT	0.373	Ovarian(172;1807 2695 35459 49286)		NA											11	32					6.42651e-13	8.32064e-13	0.010729	1	0
SPRY3	10251	broad.mit.edu	37	X	155003947	155003947	+	Silent	SNP	G	G	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:155003947G>C	uc004fnq.1	+	2	868	c.414G>C	c.(412-414)GGG>GGC	p.G138G	SPRY3_uc010nvl.1_Intron	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	138					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AATCTGCAGGGCACCCTAGTG	0.607			NA											17	67					0	0	0.004007	0	0
ODF2L	57489	broad.mit.edu	37	1	86841994	86841995	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:86841994_86841995insT	uc001dll.1	-	8	1071_1072	c.731_732insA	c.(730-732)AAGfs	p.K244fs	ODF2L_uc001dlm.1_Frame_Shift_Ins_p.K244fs|ODF2L_uc001dln.2_Frame_Shift_Ins_p.K244fs|ODF2L_uc001dlo.2_Frame_Shift_Ins_p.K113fs|ODF2L_uc001dlp.2_Frame_Shift_Ins_p.K244fs|ODF2L_uc010osg.1_Frame_Shift_Ins_p.K244fs|ODF2L_uc001dlq.1_Frame_Shift_Ins_p.K74fs|ODF2L_uc009wcr.1_Frame_Shift_Ins_p.K113fs	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	244						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CTTTAGATGCCTTTTTTAAAGC	0.347			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
RBMXL1	494115	broad.mit.edu	37	1	89448604	89448605	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:89448604_89448605insGG	uc009wcx.2	-	3	1621_1622	c.905_906insCC	c.(904-906)CCAfs	p.P302fs	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Frame_Shift_Ins_p.P302fs	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	302	Ser-rich.						nucleotide binding|RNA binding				0						CACCATAAGATGGCGGGGGCCC	0.475			NA											7	160	---	---	---	---	NA	NA	NA	NA	NA
GPR180	160897	broad.mit.edu	37	13	95254184	95254184	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:95254184delG	uc001vly.2	+	1	81	c.3delG	c.(1-3)ATGfs	p.M1fs	GPR180_uc001vlz.2_Translation_Start_Site|GPR180_uc010afi.2_Translation_Start_Site	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	1						integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AGACGGGCATGGGGGGGCTGC	0.771			NA											3	3	---	---	---	---	NA	NA	NA	NA	NA
MGA	23269	broad.mit.edu	37	15	42003214	42003220	+	Frame_Shift_Del	DEL	CATTTTA	CATTTTA	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	CATTTTA	CATTTTA	-	-	CATTTTA	CATTTTA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:42003214_42003220delCATTTTA	uc001zog.1	+	8	2842_2848	c.2751_2757delCATTTTA	c.(2749-2757)TCCATTTTAfs	p.S917fs	MGA_uc010ucy.1_Frame_Shift_Del_p.S917fs|MGA_uc010ucz.1_Frame_Shift_Del_p.S917fs	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	917_919						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CTTATAAATCCATTTTACCATACCCTG	0.396			NA											9	91	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1207090	1207091	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:1207090_1207091insA	uc002lrl.1	+	1	1293_1294	c.178_179insA	c.(178-180)TACfs	p.Y60fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	60	ATP (By similarity).|Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(3)|p.Y60fs*1(3)|p.Y60*(2)|p.G56fs*4(1)|p.G52_P179del(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGGCTCTTACGGCAAGGTG	0.629			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			12	34	---	---	---	---	NA	NA	NA	NA	NA
MARK4	57787	broad.mit.edu	37	19	45797646	45797647	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:45797646_45797647insA	uc002pbb.1	+	14	1539_1540	c.1534_1535insA	c.(1534-1536)TACfs	p.Y512fs	MARK4_uc002pba.1_Frame_Shift_Ins_p.Y512fs			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	512					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGAAACACCTACGTTTGCACA	0.599			NA											12	79	---	---	---	---	NA	NA	NA	NA	NA
CCDC13	152206	broad.mit.edu	37	3	42774410	42774410	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:42774410delA	uc003cly.3	-	12	1648	c.1564delT	c.(1564-1566)TCCfs	p.S522fs		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	522										ovary(1)	1						CTGGGCAGGGAAGGCCTCGTG	0.572			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
RAD54L2	23132	broad.mit.edu	37	3	51624506	51624508	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	GAG	GAG	-	-	GAG	GAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:51624506_51624508delGAG	uc011bdt.1	+	2	195_197	c.70_72delGAG	c.(70-72)GAGdel	p.E30del	RAD54L2_uc003dbh.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	30						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		ggatgcggaagaggaggaggagg	0.429			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MAS1L	116511	broad.mit.edu	37	6	29455156	29455157	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:29455156_29455157delAC	uc011dlq.1	-	1	523_524	c.523_524delGT	c.(523-525)GTCfs	p.V175fs		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	175	Cytoplasmic (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GGGGAAGAGGACACACACACAC	0.495	NSCLC(153;755 1987 3859 11251 32945)		NA											7	122	---	---	---	---	NA	NA	NA	NA	NA
