Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBIAD1	29914	broad.mit.edu	37	1	11345795	11345795	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:11345795G>T	uc001asg.2	+	2	958	c.624G>T	c.(622-624)GGG>GGT	p.G208G		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	208	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		TCCAGGTGGGGTCCCTGGCCA	0.597			NA											15	72					7.05477e-17	1.19137e-16	0.00499	1	0
FBXO2	26232	broad.mit.edu	37	1	11709842	11709842	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:11709842T>A	uc001asj.2	-	4	953	c.611A>T	c.(610-612)AAG>ATG	p.K204M	FBXO2_uc009vna.2_Missense_Mutation_p.K207M|FBXO2_uc009vnb.1_RNA	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	204	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		TCACCAGTCCTTCACCACGAT	0.662			NA											7	50					0	0	0.00308	0	0
FBLIM1	54751	broad.mit.edu	37	1	16101240	16101240	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:16101240G>T	uc001axd.1	+	8	1282	c.839G>T	c.(838-840)AGC>ATC	p.S280I	FBLIM1_uc001axe.1_Missense_Mutation_p.S280I|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.S280I|FBLIM1_uc001axh.1_Missense_Mutation_p.S183I|FBLIM1_uc001axi.1_Missense_Mutation_p.S183I	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	280	PLEKHC1-binding.|LIM zinc-binding 2.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		GGGGATGAGAGCTTTGCCCTG	0.642			NA											21	109					2.89027e-11	4.16395e-11	0.002299	1	0
DEPDC1	55635	broad.mit.edu	37	1	68954074	68954074	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:68954074A>G	uc001dem.3	-	5	821	c.704T>C	c.(703-705)ATA>ACA	p.I235T	DEPDC1_uc001dek.3_RNA|DEPDC1_uc001del.3_Missense_Mutation_p.I235T	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	235					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		GTTTTGTAGTATAACTACTCC	0.333			NA											15	70					0	0	0.004007	0	0
C1orf173	127254	broad.mit.edu	37	1	75037052	75037052	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:75037052G>T	uc001dgg.2	-	14	4561	c.4342C>A	c.(4342-4344)CAA>AAA	p.Q1448K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1448	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTCCTCTTGCTCCTGTCCT	0.587			NA											36	116					4.62619e-21	8.73836e-21	0.004289	1	0
C1orf173	127254	broad.mit.edu	37	1	75078489	75078489	+	Silent	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:75078489G>C	uc001dgg.2	-	9	1224	c.1005C>G	c.(1003-1005)ACC>ACG	p.T335T	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.T129T	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	335										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TAAACTGAAAGGTCTCTGGAA	0.353			NA											9	29					0	0	0.006214	0	0
TTLL7	79739	broad.mit.edu	37	1	84403666	84403666	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:84403666C>A	uc001djc.2	-	8	1153	c.757G>T	c.(757-759)GTG>TTG	p.V253L	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	253	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TGCTTGTTCACGGAGTAGTTT	0.398			NA											24	78					9.95505e-16	1.59656e-15	0.002299	1	0
FRRS1	391059	broad.mit.edu	37	1	100185118	100185118	+	Silent	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:100185118G>A	uc001dsh.1	-	10	1694	c.1092C>T	c.(1090-1092)TCC>TCT	p.S364S		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	364	Cytochrome b561.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		GTACAGAATGGGATCCTCCTA	0.408			NA											24	44					0	0	0.00278	0	0
DBT	1629	broad.mit.edu	37	1	100672123	100672123	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:100672123G>A	uc001dta.2	-	9	1120	c.1087C>T	c.(1087-1089)CAG>TAG	p.Q363*	DBT_uc010oug.1_Nonsense_Mutation_p.Q182*	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	363					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		GAGCAGATCTGAACATTTTTC	0.418			NA											77	192					0	0	0.00361	0	0
SYCP1	6847	broad.mit.edu	37	1	115418714	115418714	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:115418714C>G	uc001efr.2	+	10	891	c.682C>G	c.(682-684)CTT>GTT	p.L228V	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.L228V|SYCP1_uc009wgw.2_Missense_Mutation_p.L228V	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	228	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTTGAGGAACTTCGTGTGCA	0.259			NA											17	47					0	0	0.004007	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144877096	144877096	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:144877096G>T	uc001elw.3	-	28	4882	c.4591C>A	c.(4591-4593)CGG>AGG	p.R1531R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.R1487R|PDE4DIP_uc001elv.3_Silent_p.R538R	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1531					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGTTGCTCCCGGAAGCTCTGT	0.493			NA	T	PDGFRB	MPD								11	44					5.50884e-06	6.35635e-06	0.001368	1	0
NUDT17	200035	broad.mit.edu	37	1	145586946	145586946	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:145586946G>T	uc001eoe.2	-	7	750	c.742C>A	c.(742-744)CTA>ATA	p.L248I	NBPF10_uc001emp.3_Intron	NM_001012758	NP_001012776	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety	248							hydrolase activity|metal ion binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCCTCCTCTAGTTCCACTGCA	0.398			NA											30	89					3.99451e-17	6.79066e-17	0.009535	1	0
FLG2	388698	broad.mit.edu	37	1	152328737	152328737	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:152328737C>T	uc001ezw.3	-	3	1598	c.1525G>A	c.(1525-1527)GGG>AGG	p.G509R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	509	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGACAGACCCATGCTGTCCA	0.522			NA											66	199					0	0	0.00361	0	0
PFDN2	5202	broad.mit.edu	37	1	161087769	161087769	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:161087769C>A	uc001fxu.2	-	1	98	c.48G>T	c.(46-48)GCG>GCT	p.A16A	NIT1_uc001fxv.1_5'Flank|NIT1_uc001fxw.2_5'Flank|NIT1_uc001fxx.1_5'Flank|NIT1_uc001fxy.1_5'Flank|NIT1_uc010pka.1_5'Flank	NM_012394	NP_036526	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	16				SGAGKGAVS -> TPRRGRGRCP (in Ref. 2; AAD47084).	'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding				0	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCCCCTTCCCCGCGCCGCTCC	0.701			NA											10	42					4.68919e-08	6.13202e-08	0.008291	1	0
PAPPA2	60676	broad.mit.edu	37	1	176668286	176668286	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:176668286C>A	uc001gkz.2	+	8	3961	c.2797C>A	c.(2797-2799)CCT>ACT	p.P933T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	933					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGCCTGGAGCCCTGAGGTCCA	0.572			NA											38	62					1.32136e-16	2.20226e-16	0.00874	1	0
CACNA1E	777	broad.mit.edu	37	1	181702858	181702858	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:181702858C>T	uc001gow.2	+	21	3399	c.3234C>T	c.(3232-3234)GAC>GAT	p.D1078D	CACNA1E_uc009wxs.2_Silent_p.D966D|CACNA1E_uc001gox.1_Silent_p.D304D|CACNA1E_uc009wxt.2_Silent_p.D304D	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1078	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCGACGTGGACCCCTTGGTGG	0.622			NA											6	12					0	0	0.001168	0	0
ASPM	259266	broad.mit.edu	37	1	197070841	197070841	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:197070841A>T	uc001gtu.2	-	18	7797	c.7540T>A	c.(7540-7542)TAT>AAT	p.Y2514N	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.Y362N	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2514					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TATGTTCGATAATGTTGCTGA	0.363			NA											30	81					0	0	0.008361	0	0
PIGR	5284	broad.mit.edu	37	1	207105801	207105801	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:207105801C>T	uc001hez.2	-	8	2192	c.2008G>A	c.(2008-2010)GAC>AAC	p.D670N	PIGR_uc009xbz.2_Missense_Mutation_p.D670N	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	670	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGGGACTCACCGACGTTCTTC	0.632			NA											26	101					0	0	0.00333	0	0
USH2A	7399	broad.mit.edu	37	1	216462704	216462704	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:216462704G>T	uc001hku.1	-	11	2276	c.1889C>A	c.(1888-1890)GCA>GAA	p.A630E	USH2A_uc001hkv.2_Missense_Mutation_p.A630E	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	630	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CGAAGGATCTGCACCAACTTG	0.413			NA								HNSCC(13;0.011)			26	66					1.04121e-07	1.34776e-07	0.005443	1	0
PLD5	200150	broad.mit.edu	37	1	242253245	242253245	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:242253245G>T	uc001hzn.1	-	10	1649	c.1522C>A	c.(1522-1524)CCG>ACG	p.P508T	PLD5_uc001hzl.3_Missense_Mutation_p.P446T|PLD5_uc001hzm.3_Missense_Mutation_p.P298T|PLD5_uc001hzo.1_Missense_Mutation_p.P416T			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	508						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GAGCAGTTCGGCTGTTTGGTT	0.458			NA											64	149					9.39563e-20	1.73615e-19	0.00361	1	0
ZNF670	93474	broad.mit.edu	37	1	247201596	247201596	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:247201596C>A	uc001icd.1	-	4	496	c.325G>T	c.(325-327)GGA>TGA	p.G109*	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	109	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			AAGACTTTTCCACACACACTG	0.393			NA											34	130					3.11337e-16	5.122e-16	0.002836	1	0
OR2T1	26696	broad.mit.edu	37	1	248569559	248569559	+	Silent	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:248569559A>G	uc010pzm.1	+	1	264	c.264A>G	c.(262-264)GCA>GCG	p.A88A		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	88	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTTCACCGCACTGATGGCCA	0.443			NA											25	110					0	0	0.005443	0	0
OR2T27	403239	broad.mit.edu	37	1	248813976	248813976	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:248813976G>T	uc010pzo.1	-	1	210	c.210C>A	c.(208-210)GAC>GAA	p.D70E		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TATACAGGATGTCCCTGAGGG	0.537			NA											4	36					4.3838e-07	5.40033e-07	0.001855	1	0
SEC61A2	55176	broad.mit.edu	37	10	12191875	12191875	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:12191875G>T	uc001ile.2	+	6	524	c.377G>T	c.(376-378)GGG>GTG	p.G126V	SEC61A2_uc010qbq.1_Missense_Mutation_p.G104V|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Missense_Mutation_p.G126V	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	126	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				ATTACCATTGGGCAAGCCATT	0.448			NA											26	47					3.73988e-18	6.66902e-18	0.00632	1	0
CUBN	8029	broad.mit.edu	37	10	16873346	16873346	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:16873346A>T	uc001ioo.2	-	65	10485	c.10433T>A	c.(10432-10434)GTC>GAC	p.V3478D		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3478	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGAGAGAAGACAGGGTTTGG	0.393			NA											17	66					0	0	0.00499	0	0
COMMD3	23412	broad.mit.edu	37	10	22607738	22607738	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:22607738A>G	uc001irf.2	+	6	463	c.415A>G	c.(415-417)AAT>GAT	p.N139D	COMMD3_uc001ire.2_3'UTR|COMMD3_uc001irg.2_RNA|BMI1_uc009xkg.2_Intron|BMI1_uc001irh.2_5'Flank	NM_012071	NP_036203	Q9UBI1	COMD3_HUMAN	COMM domain containing 3	139	COMM.						protein binding				0						ATTTTAGACCAATCAACTTCA	0.323			NA											41	79					0	0	0.010771	0	0
FRMPD2	143162	broad.mit.edu	37	10	49430483	49430483	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:49430483G>T	uc001jgi.2	-	12	1435	c.1328C>A	c.(1327-1329)ACA>AAA	p.T443K	FRMPD2_uc001jgh.2_Missense_Mutation_p.T412K|FRMPD2_uc001jgj.2_Missense_Mutation_p.T421K	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	443	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTGGTGCCTTGTCAGGCTGTG	0.507			NA											22	39					1.50039e-11	2.19885e-11	0.012319	1	0
C10orf11	83938	broad.mit.edu	37	10	78317043	78317043	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:78317043C>T	uc001jxi.2	+	6	809	c.594C>T	c.(592-594)CTC>CTT	p.L198L		NM_032024	NP_114413	Q9H2I8	CJ011_HUMAN	chromosome 10 open reading frame 11	198											0	Prostate(51;0.0095)|all_epithelial(25;0.0221)					ATGACCAGCTCTGAAGCCAAC	0.388			NA											11	20					0	0	0.010729	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647236	78647236	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:78647236C>A	uc001jxn.2	-	28	3676	c.3499G>T	c.(3499-3501)GTG>TTG	p.V1167L	KCNMA1_uc001jxj.2_Missense_Mutation_p.V1113L|KCNMA1_uc001jxk.1_Missense_Mutation_p.V785L|KCNMA1_uc009xrt.1_Missense_Mutation_p.V958L|KCNMA1_uc001jxl.1_Missense_Mutation_p.V792L|KCNMA1_uc001jxo.2_Missense_Mutation_p.V1150L|KCNMA1_uc001jxm.2_Missense_Mutation_p.V1109L|KCNMA1_uc001jxq.2_Missense_Mutation_p.V1139L|uc001jxp.2_5'Flank	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1167	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TCCGTCGGCACGAGCTCAAAC	0.547			NA											10	24					3.07112e-06	3.64249e-06	0.010729	1	0
BTAF1	9044	broad.mit.edu	37	10	93744142	93744142	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:93744142T>C	uc001khr.2	+	19	2506	c.2408T>C	c.(2407-2409)ATA>ACA	p.I803T	BTAF1_uc001khs.1_Missense_Mutation_p.I473T|BTAF1_uc001kht.1_Missense_Mutation_p.I241T	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	803					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				GTTTTAACAATAGATCAAGCT	0.299			NA											5	22					0	0	0.000602	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98405277	98405277	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:98405277A>T	uc001kmq.2	-	8	1456	c.1328T>A	c.(1327-1329)CTC>CAC	p.L443H	PIK3AP1_uc001kmp.2_Missense_Mutation_p.L265H	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	443						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GGACTCATAGAGATCCTCGTC	0.537			NA											10	33					0	0	0.008291	0	0
ATRNL1	26033	broad.mit.edu	37	10	117045738	117045738	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:117045738G>A	uc001lcg.2	+	15	2632	c.2246G>A	c.(2245-2247)GGA>GAA	p.G749E		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	749	PSI 3.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CATCTTTGTGGAGAAGGATGG	0.303			NA											7	31					0	0	0.00308	0	0
VAX1	11023	broad.mit.edu	37	10	118897464	118897464	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:118897464G>T	uc009xyx.2	-	1	349	c.104C>A	c.(103-105)GCG>GAG	p.A35E	VAX1_uc001ldb.1_Missense_Mutation_p.A35E	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	35						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		GTTCCCCTCCGCGCCCTTGCT	0.612			NA											22	63					9.57634e-11	1.33441e-10	0.00333	1	0
PDZD8	118987	broad.mit.edu	37	10	119043833	119043833	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:119043833T>A	uc001lde.1	-	5	2610	c.2411A>T	c.(2410-2412)CAT>CTT	p.H804L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	804					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AGTAACTACATGGTGGTCTGA	0.363			NA											11	62					0	0	0.010729	0	0
STK32C	282974	broad.mit.edu	37	10	134038769	134038769	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr10:134038769C>A	uc001lle.1	-	7	984	c.844G>T	c.(844-846)GGG>TGG	p.G282W	STK32C_uc001lld.1_Missense_Mutation_p.G165W|STK32C_uc010quu.1_Missense_Mutation_p.G295W|STK32C_uc009ybc.1_Missense_Mutation_p.G165W|STK32C_uc009ybd.1_3'UTR|STK32C_uc001llb.2_Missense_Mutation_p.G53W|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	282	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		GCCATCACCCCCACCGACCAC	0.622			NA											4	13					0.00024832	0.000264944	0.009096	1	0
MUC2	4583	broad.mit.edu	37	11	1098690	1098690	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:1098690G>C	uc001lsx.1	+	40	14173	c.14146G>C	c.(14146-14148)GCC>CCC	p.A4716P		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4716						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CTACTACGATGCCTGCGTGTT	0.647			NA											5	12					0	0	0.001168	0	0
MUC5B	727897	broad.mit.edu	37	11	1264035	1264035	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:1264035C>A	uc009ycr.1	+	47	8130	c.8004C>A	c.(8002-8004)CCC>CCA	p.P2668P	MUC5B_uc001ltb.2_Silent_p.P1978P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1975	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACCACACCCACAGCTACCA	0.637			NA											44	77					3.4345e-17	5.87783e-17	0.011902	1	0
H19	283120	broad.mit.edu	37	11	2017334	2017334	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:2017334C>G	uc001lvc.1	-	3	1537	c.919G>C	c.(919-921)GGC>CGC	p.G307R	H19_uc001luz.1_RNA|H19_uc001lva.3_RNA|H19_uc001lvd.2_RNA|H19_uc001lve.2_RNA|H19_uc001lvb.1_RNA					SubName: Full=cDNA FLJ32212 fis, clone PLACE6003399, weakly similar to SPIDROIN 1;												0						TTCTGGGAGCCCAGAGGGCAG	0.602			NA							Beckwith-Wiedemann_syndrome				3	4					0	0	0.004672	0	0
KCNQ1	3784	broad.mit.edu	37	11	2591907	2591907	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:2591907G>C	uc001lwn.2	+	3	635	c.527G>C	c.(526-528)TGG>TCG	p.W176S	KCNQ1_uc009ydp.1_Intron|KCNQ1_uc001lwo.2_Missense_Mutation_p.W49S	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	176	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	GTCCGCCTCTGGTCCGCCGGC	0.657			NA											8	27					0	0	0.006214	0	0
STIM1	6786	broad.mit.edu	37	11	4104601	4104601	+	Silent	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:4104601A>T	uc001lyv.2	+	10	1915	c.1347A>T	c.(1345-1347)TCA>TCT	p.S449S	STIM1_uc009yef.2_Silent_p.S449S|STIM1_uc009yeg.2_Silent_p.S276S	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	449	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		GCATCCACTCACTGGTGGCTG	0.582			NA											16	40					0	0	0.004007	0	0
OR52E4	390081	broad.mit.edu	37	11	5906021	5906021	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:5906021C>G	uc010qzs.1	+	1	499	c.499C>G	c.(499-501)CGT>GGT	p.R167G	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTCATTCTGCGTCTGCCATT	0.453			NA											23	75					0	0	0.002836	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806406	6806406	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:6806406C>A	uc001mer.1	+	1	138	c.138C>A	c.(136-138)CTC>CTA	p.L46L		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCCTACTGCTCCTGGCTATCA	0.522			NA											31	104					2.80507e-11	4.06417e-11	0.012213	1	0
ZDHHC13	54503	broad.mit.edu	37	11	19177405	19177405	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:19177405C>T	uc001mpi.2	+	9	1041	c.936C>T	c.(934-936)TTC>TTT	p.F312F	ZDHHC13_uc001mpj.2_Silent_p.F182F	NM_019028	NP_061901	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC domain containing 13 isoform	312	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding				0						TATTGGACTTCAATTCAGATT	0.353			NA											20	30					0	0	0.010504	0	0
CAT	847	broad.mit.edu	37	11	34478364	34478364	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:34478364G>T	uc001mvm.2	+	8	1139	c.1056G>T	c.(1054-1056)CAG>CAT	p.Q352H	CAT_uc009ykc.1_RNA	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	352					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	AAATGCTTCAGGTGAGCCTGG	0.468			NA											14	34					2.23348e-06	2.67389e-06	0.004007	1	0
LOC440040	440040	broad.mit.edu	37	11	49830115	49830115	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:49830115C>T	uc010rhy.1	+	6	1433	c.955C>T	c.(955-957)CCC>TCC	p.P319S	LOC440040_uc009ymb.2_Missense_Mutation_p.P319S	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						GCTGCACATGCCCCAGCCTCT	0.463			NA											3	29					0	0	0.001168	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431279	56431279	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:56431279G>T	uc010rjm.1	+	1	118	c.118G>T	c.(118-120)GTG>TTG	p.V40L		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGTTAATGTAGTGGGGAATAT	0.443			NA											53	170					7.91745e-34	1.56508e-33	0.00361	1	0
TRPT1	83707	broad.mit.edu	37	11	63992969	63992969	+	Splice_Site	SNP	A	A	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:63992969A>C	uc001nyo.2	-	3	371	c.157_splice	c.e3+1	p.D53_splice	TRPT1_uc010rnc.1_Splice_Site_p.D53_splice|TRPT1_uc010rnd.1_Splice_Site_p.D53_splice|TRPT1_uc001nyn.2_Splice_Site_p.D4_splice|TRPT1_uc010rne.1_Splice_Site_p.D53_splice|TRPT1_uc010rnf.1_Splice_Site_p.D53_splice|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank|NUDT22_uc010rng.1_5'Flank	NM_001033678	NP_001028850	Q86TN4	TRPT1_HUMAN	tRNA phosphotransferase 1 isoform 1								tRNA 2'-phosphotransferase activity				0						GCCCCTACTTACCAGCTCCCA	0.637			NA											6	12					0	0	0.00308	0	0
CCDC87	55231	broad.mit.edu	37	11	66358319	66358319	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:66358319C>T	uc001oiq.3	-	1	2236	c.2168G>A	c.(2167-2169)CGG>CAG	p.R723Q	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	723										ovary(1)|skin(1)	2						CTTCAGGGCCCGCTCCCAGGC	0.552			NA											44	94					0	0	0.009718	0	0
FGF19	9965	broad.mit.edu	37	11	69514154	69514154	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:69514154G>T	uc001opf.2	-	3	990	c.527C>A	c.(526-528)CCT>CAT	p.P176H		NM_005117	NP_005108	O95750	FGF19_HUMAN	fibroblast growth factor 19 precursor	176					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			skin(1)	1	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			GAGGTCCTCAGGCTCCTCTGG	0.587			NA											29	85					4.2108e-06	4.92548e-06	0.009535	1	0
P2RY6	5031	broad.mit.edu	37	11	73008274	73008274	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:73008274G>T	uc001otm.2	+	4	1116	c.711G>T	c.(709-711)GCG>GCT	p.A237A	P2RY6_uc001otn.2_Silent_p.A237A|P2RY6_uc001oto.2_Silent_p.A237A|P2RY6_uc001otp.2_Silent_p.A237A|P2RY6_uc001otq.2_Silent_p.A237A|P2RY6_uc001otr.2_Silent_p.A237A|P2RY6_uc001ots.2_Silent_p.A237A	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	237	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						GTGGCAAGGCGGCCCGCATGG	0.687			NA											31	80					8.16721e-17	1.37016e-16	0.010818	1	0
ARHGEF17	9828	broad.mit.edu	37	11	73020531	73020531	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:73020531G>T	uc001otu.2	+	1	869	c.848G>T	c.(847-849)GGT>GTT	p.G283V		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	283					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GACCGAGACGGTGAGGGCGGC	0.677			NA											13	23					4.36969e-10	5.9907e-10	0.001855	1	0
PCF11	51585	broad.mit.edu	37	11	82876987	82876987	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:82876987G>T	uc001ozx.3	+	5	1393	c.1048G>T	c.(1048-1050)GAA>TAA	p.E350*	PCF11_uc010rsu.1_Nonsense_Mutation_p.E350*	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	350	Lys-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TAAATCAGGTGAAAAAATAAC	0.303			NA											3	11					0.00024832	0.000264944	0.009096	1	0
FAT3	120114	broad.mit.edu	37	11	92590441	92590441	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:92590441G>T	uc001pdj.3	+	19	11444	c.11427G>T	c.(11425-11427)CAG>CAT	p.Q3809H	FAT3_uc001pdi.3_Missense_Mutation_p.Q249H	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3809	EGF-like 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGGACATGCAGTGTGTCAGTT	0.547			NA								TCGA Ovarian(4;0.039)			18	60					1.99824e-07	2.5101e-07	0.00499	1	0
MTNR1B	4544	broad.mit.edu	37	11	92714983	92714983	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:92714983C>A	uc001pdk.1	+	2	697	c.594C>A	c.(592-594)ACC>ACA	p.T198T		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	198	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CCGCCAGCACCCAGTACACGG	0.617			NA											8	29					9.31168e-06	1.06479e-05	0.001855	1	0
IL10RA	3587	broad.mit.edu	37	11	117869691	117869691	+	Missense_Mutation	SNP	G	G	T	rs78753252	byFrequency	TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:117869691G>T	uc001prv.2	+	7	1149	c.1072G>T	c.(1072-1074)GAC>TAC	p.D358Y	IL10RA_uc010rxl.1_Missense_Mutation_p.D338Y|IL10RA_uc010rxm.1_Missense_Mutation_p.D338Y|IL10RA_uc010rxn.1_Missense_Mutation_p.D209Y|IL10RA_uc001prw.2_Missense_Mutation_p.D209Y	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	358	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TGTGCTGGGGGACAGCTGCAG	0.647			NA											8	35					1.76689e-08	2.32246e-08	0.006214	1	0
TRIM29	23650	broad.mit.edu	37	11	120008387	120008387	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:120008387G>T	uc001pwz.2	-	1	477	c.353C>A	c.(352-354)CCC>CAC	p.P118H	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	118					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		AAAGGTAACGGGTGGCTTCTT	0.617			NA											69	213					1.70537e-16	2.82383e-16	0.00361	1	0
ZNF202	7753	broad.mit.edu	37	11	123600515	123600515	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:123600515C>A	uc001pzd.1	-	5	821	c.421G>T	c.(421-423)GGC>TGC	p.G141C	ZNF202_uc001pzc.1_5'UTR|ZNF202_uc001pze.1_Missense_Mutation_p.G141C|ZNF202_uc001pzf.1_Missense_Mutation_p.G141C	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	141					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		ACTTCCTGGCCGTGAACATGG	0.522			NA											17	30					7.07596e-05	7.81112e-05	0.006122	1	0
PANX3	116337	broad.mit.edu	37	11	124487352	124487352	+	Silent	SNP	C	C	T	rs147550190		TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr11:124487352C>T	uc001qah.2	+	3	507	c.507C>T	c.(505-507)TCC>TCT	p.S169S		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	169	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		AGAAGAGTTCCGACCCCTATG	0.458			NA											22	44					0	0	0.00278	0	0
AKAP3	10566	broad.mit.edu	37	12	4736589	4736589	+	Silent	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:4736589G>C	uc001qnb.3	-	4	1708	c.1479C>G	c.(1477-1479)TCC>TCG	p.S493S		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	493					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						GGTACTCAAAGGAAATGTCTG	0.458			NA											11	24					0	0	0.008291	0	0
LRRC23	10233	broad.mit.edu	37	12	7014864	7014864	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:7014864G>T	uc001qrt.3	+	2	459	c.67G>T	c.(67-69)GAG>TAG	p.E23*	LRRC23_uc001qrn.1_Nonsense_Mutation_p.E23*|LRRC23_uc009zfg.2_Intron|LRRC23_uc001qrp.2_Nonsense_Mutation_p.E23*|LRRC23_uc001qrq.2_Nonsense_Mutation_p.E23*|LRRC23_uc001qrr.2_Silent_p.T8T|LRRC23_uc001qrs.2_Silent_p.T8T|LRRC23_uc009zfh.2_Nonsense_Mutation_p.E23*	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	23										ovary(1)	1						agaagaggacgagaaggagac	0.348			NA											11	48					1.08611e-07	1.38479e-07	0.010729	1	0
IFLTD1	160492	broad.mit.edu	37	12	25702345	25702345	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:25702345C>A	uc001rgs.2	-	2	312	c.162G>T	c.(160-162)CAG>CAT	p.Q54H	IFLTD1_uc001rgt.1_5'UTR|IFLTD1_uc010sji.1_Missense_Mutation_p.Q75H|IFLTD1_uc010sjj.1_Intron|IFLTD1_uc009zjc.2_Missense_Mutation_p.Q75H	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	54						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					CTCTACTAATCTGAGGACTAG	0.408			NA											22	49					7.87624e-14	1.21724e-13	0.00278	1	0
OVCH1	341350	broad.mit.edu	37	12	29642629	29642629	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:29642629T>A	uc001rix.1	-	6	626	c.626A>T	c.(625-627)AAG>ATG	p.K209M		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	209	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GTTCATGCTCTTGAGCACAGT	0.483			NA											5	17					0	0	0.001984	0	0
KRT6B	3854	broad.mit.edu	37	12	52841671	52841671	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:52841671G>T	uc001sak.2	-	7	1363	c.1315C>A	c.(1315-1317)CAG>AAG	p.Q439K		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	439	Rod.|Coil 2.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		GCCAGGTCCTGCTTGGCCTTC	0.617			NA											36	76					6.97489e-18	1.21822e-17	0.004878	1	0
KRT4	3851	broad.mit.edu	37	12	53201583	53201583	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:53201583G>T	uc001saz.2	-	7	1684	c.1413C>A	c.(1411-1413)GCC>GCA	p.A471A		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	397						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GCTTGCTGTGGGCATCTTTAA	0.562	Pancreas(190;284 2995 41444 45903)		NA											17	38					5.03518e-11	7.17303e-11	0.007413	1	0
DGKA	1606	broad.mit.edu	37	12	56346633	56346633	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:56346633G>A	uc001sij.2	+	21	2123	c.1859G>A	c.(1858-1860)GGG>GAG	p.G620E	DGKA_uc009zod.1_Missense_Mutation_p.G539E|DGKA_uc001sik.2_Missense_Mutation_p.G620E|DGKA_uc001sil.2_Missense_Mutation_p.G620E|DGKA_uc001sim.2_Missense_Mutation_p.G620E|DGKA_uc001sin.2_Missense_Mutation_p.G620E|DGKA_uc009zof.2_Missense_Mutation_p.G266E|DGKA_uc001sio.2_Missense_Mutation_p.G362E	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	620					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	AGACCCCATGGGGATATCTAT	0.532			NA											32	142					0	0	0.010818	0	0
GLI1	2735	broad.mit.edu	37	12	57858560	57858560	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:57858560C>T	uc001snx.2	+	4	376	c.298C>T	c.(298-300)CGC>TGC	p.R100C	GLI1_uc009zpp.2_RNA|GLI1_uc009zpq.2_5'UTR|GLI1_uc009zpr.1_RNA	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	100					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			GACGGTTATCCGCACCTCACC	0.567	Pancreas(157;841 1936 10503 41495 50368)		NA											24	55					0	0	0.00278	0	0
GLI1	2735	broad.mit.edu	37	12	57858976	57858976	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:57858976G>T	uc001snx.2	+	5	550	c.472G>T	c.(472-474)GAC>TAC	p.D158Y	GLI1_uc009zpq.2_Missense_Mutation_p.D30Y	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	158					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TGGTCCCCATGACTCTGCCCG	0.597	Pancreas(157;841 1936 10503 41495 50368)		NA											9	32					1.58986e-06	1.9214e-06	0.008291	1	0
SRGAP1	57522	broad.mit.edu	37	12	64491115	64491115	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:64491115C>T	uc010ssp.1	+	15	1829	c.1773C>T	c.(1771-1773)CTC>CTT	p.L591L	SRGAP1_uc001srv.2_Silent_p.L528L	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	591	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		AAAACCCCCTCTTTCCTAAGG	0.393			NA											12	42					0	0	0.010729	0	0
LHX5	64211	broad.mit.edu	37	12	113907096	113907096	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:113907096C>A	uc001tvj.1	-	2	802	c.228G>T	c.(226-228)CTG>CTT	p.L76L		NM_022363	NP_071758	Q9H2C1	LHX5_HUMAN	LIM homeobox protein 5	76	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCTTGCGCACCAGGTCGCTGG	0.602			NA											18	53					8.04996e-18	1.39642e-17	0.012319	1	0
TBX5	6910	broad.mit.edu	37	12	114793888	114793888	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:114793888G>A	uc001tvo.2	-	9	1501	c.1006C>T	c.(1006-1008)CAT>TAT	p.H336Y	TBX5_uc001tvp.2_Missense_Mutation_p.H336Y|TBX5_uc001tvq.2_Missense_Mutation_p.H286Y	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	336					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTATAGGGATGGTCTGTGGTG	0.532	NSCLC(152;1358 1980 4050 23898 40356)		NA											7	110					0	0	0.001984	0	0
RPLP0	6175	broad.mit.edu	37	12	120636469	120636469	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr12:120636469A>C	uc001txp.2	-	6	776	c.539T>G	c.(538-540)ATC>AGC	p.I180S	RPLP0_uc001txq.2_Missense_Mutation_p.I180S|RPLP0_uc001txr.2_Intron|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	180					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAAGGGGGAGATGTTGAGCAT	0.507			NA											17	48					0	0	0.008871	0	0
TRPC4	7223	broad.mit.edu	37	13	38237654	38237654	+	Silent	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr13:38237654T>C	uc001uws.2	-	6	1822	c.1587A>G	c.(1585-1587)GCA>GCG	p.A529A	TRPC4_uc010abv.2_Silent_p.A109A|TRPC4_uc001uwt.2_Silent_p.A529A|TRPC4_uc010tey.1_Silent_p.A529A|TRPC4_uc010abw.2_Silent_p.A356A|TRPC4_uc010abx.2_Silent_p.A529A|TRPC4_uc010aby.2_Silent_p.A529A	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	529	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CATTTGCAAATGCTAGCAACA	0.373			NA											23	26					0	0	0.002299	0	0
CKAP2	26586	broad.mit.edu	37	13	53036592	53036592	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr13:53036592G>A	uc001vgv.2	+	5	1395	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	CKAP2_uc001vgt.2_Missense_Mutation_p.E399K|CKAP2_uc001vgu.2_Missense_Mutation_p.E399K|CKAP2_uc010tha.1_Missense_Mutation_p.E351K	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	400					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		AGGACAAAATGAAAAACCAGT	0.408			NA											13	31					0	0	0.001368	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454814	84454814	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr13:84454814G>T	uc001vlk.2	-	1	1715	c.829C>A	c.(829-831)CAA>AAA	p.Q277K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	277	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTCTCTTCTTGGGCAGGGGGC	0.542			NA											21	28					7.41877e-09	9.90464e-09	0.012319	1	0
SLC15A1	6564	broad.mit.edu	37	13	99340562	99340562	+	Silent	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr13:99340562A>T	uc001vno.2	-	20	1700	c.1623T>A	c.(1621-1623)CCT>CCA	p.P541P		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	541	Extracellular (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	TATTGAAATTAGGTTGACATT	0.323			NA											16	79					0	0	0.006122	0	0
FUT8	2530	broad.mit.edu	37	14	66028456	66028456	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr14:66028456G>A	uc001xin.2	+	3	1372	c.175G>A	c.(175-177)GAC>AAC	p.D59N	FUT8_uc001xio.2_Missense_Mutation_p.D59N|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.D59N|FUT8_uc001xiq.2_Intron	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	59	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		ACAGAATGAAGACTTGAGGCG	0.428			NA											16	21					0	0	0.004007	0	0
C15orf2	23742	broad.mit.edu	37	15	24922411	24922411	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr15:24922411C>A	uc001ywo.2	+	1	1871	c.1397C>A	c.(1396-1398)CCT>CAT	p.P466H		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	466	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTGGCTCTTCCTGCTGACCTT	0.493			NA											35	116					4.3181e-19	7.86511e-19	0.002836	1	0
C15orf2	23742	broad.mit.edu	37	15	24923271	24923271	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr15:24923271G>T	uc001ywo.2	+	1	2731	c.2257G>T	c.(2257-2259)GTC>TTC	p.V753F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	753					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGCACAGTCAGTCAGGGCACC	0.567			NA											41	114					4.14481e-20	7.77152e-20	0.00623	1	0
SPTBN5	51332	broad.mit.edu	37	15	42147077	42147077	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr15:42147077C>A	uc001zos.2	-	56	9749	c.9416G>T	c.(9415-9417)CGG>CTG	p.R3139L		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3174	Spectrin 28.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GGGTGCACCCCGCTCCAGGGT	0.587			NA											12	40					1.5842e-08	2.10402e-08	0.001855	1	0
ADAMTS17	170691	broad.mit.edu	37	15	100636656	100636656	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr15:100636656C>A	uc002bvv.1	-	15	2121	c.2042G>T	c.(2041-2043)GGG>GTG	p.G681V	ADAMTS17_uc002bvx.1_Missense_Mutation_p.G438V	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	681	Cys-rich.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GGCTGCAGACCCGATGATGCC	0.572			NA											23	86					1.10513e-12	1.66751e-12	0.002299	1	0
IL21R	50615	broad.mit.edu	37	16	27445756	27445756	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr16:27445756G>T	uc002doq.1	+	3	371	c.138G>T	c.(136-138)ACG>ACT	p.T46T	IL21R_uc002dor.1_Silent_p.T46T|IL21R_uc002dos.1_Silent_p.T46T	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	46	Extracellular (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						ACCCCAGCACGCTCACCCTTA	0.617			NA	T	BCL6	NHL								7	7					5.18039e-06	6.03196e-06	0.00308	1	0
SALL1	6299	broad.mit.edu	37	16	51176012	51176012	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr16:51176012C>G	uc010vgs.1	-	2	152	c.121G>C	c.(121-123)GAT>CAT	p.D41H	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	41					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACGTGGGCATCCTTGCTCTTA	0.458	GBM(103;1352 1446 1855 4775 8890)		NA											28	84					0	0	0.010818	0	0
TXNL4B	54957	broad.mit.edu	37	16	72124580	72124580	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr16:72124580C>A	uc002fca.2	-	2	380	c.69G>T	c.(67-69)GAG>GAT	p.E23D	TXNL4B_uc010cgl.2_RNA|TXNL4B_uc010vmn.1_Missense_Mutation_p.E23D|TXNL4B_uc010vmo.1_Missense_Mutation_p.E23D	NM_017853	NP_060323	Q9NX01	TXN4B_HUMAN	thioredoxin-like 4B	23					mitosis|mRNA processing|RNA splicing	spliceosomal complex				ovary(1)	1						CCAACACCTTCTCAGCAGTAC	0.393			NA											21	55					1.50039e-11	2.19885e-11	0.012319	1	0
OR3A1	4994	broad.mit.edu	37	17	3195311	3195311	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:3195311T>C	uc002fvh.1	-	1	566	c.566A>G	c.(565-567)CAG>CGG	p.Q189R		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						GCAGGAGAGCTGGAAGAGCTG	0.517	GBM(20;287 516 18743 28660 36594)		NA											31	64					0	0	0.003271	0	0
FXR2	9513	broad.mit.edu	37	17	7495160	7495160	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:7495160A>T	uc002gia.1	-	17	2237	c.2010T>A	c.(2008-2010)AAT>AAA	p.N670K	MPDU1_uc010vuc.1_Intron|SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	670						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		ATGAAACCCCATTCACCATAC	0.592			NA											9	17					0	0	0.006214	0	0
TP53	7157	broad.mit.edu	37	17	7577105	7577105	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:7577105G>T	uc002gim.2	-	8	1027	c.833C>A	c.(832-834)CCT>CAT	p.P278H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.P278H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P146H|TP53_uc010cng.1_Missense_Mutation_p.P146H|TP53_uc002gii.1_Missense_Mutation_p.P146H|TP53_uc010cnh.1_Missense_Mutation_p.P278H|TP53_uc010cni.1_Missense_Mutation_p.P278H|TP53_uc002gij.2_Missense_Mutation_p.P278H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(17)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.P278fs*28(2)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCTCTCCCAGGACAGGCACA	0.552	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	16					2.27111e-07	2.83889e-07	0.001368	1	0
TP53	7157	broad.mit.edu	37	17	7577138	7577138	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:7577138C>A	uc002gim.2	-	8	994	c.800G>T	c.(799-801)CGG>CTG	p.R267L	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R267L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R135L|TP53_uc010cng.1_Missense_Mutation_p.R135L|TP53_uc002gii.1_Missense_Mutation_p.R135L|TP53_uc010cnh.1_Missense_Mutation_p.R267L|TP53_uc010cni.1_Missense_Mutation_p.R267L|TP53_uc002gij.2_Missense_Mutation_p.R267L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	267	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> H (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R267W(20)|p.R267P(13)|p.0?(7)|p.R267Q(7)|p.R267R(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.R267fs*78(1)|p.N268fs*77(1)|p.L265_K305del41(1)|p.R267G(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.R267L(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAAGCTGTTCCGTCCCAGTAG	0.527	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	18					0.004672	0.00486269	0.004672	1	0
PIK3R6	146850	broad.mit.edu	37	17	8731976	8731976	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:8731976C>A	uc002glq.1	-	11	1461	c.1221G>T	c.(1219-1221)CTG>CTT	p.L407L	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	407					platelet activation	cytosol					0						ACACGCCGGGCAGCATTTCCC	0.697			NA											6	11					3.59834e-05	4.04218e-05	0.001168	1	0
PIK3R5	23533	broad.mit.edu	37	17	8785177	8785177	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:8785177G>A	uc002glt.2	-	16	2294	c.2227C>T	c.(2227-2229)CGC>TGC	p.R743C	PIK3R5_uc010vuz.1_Missense_Mutation_p.R743C|PIK3R5_uc002glu.3_Missense_Mutation_p.R357C	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	743	Interaction with G beta gamma proteins (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						TTGCTCCAGCGACTTCGTCCA	0.612	NSCLC(18;589 615 7696 20311 50332)		NA											8	12					0	0	0.00308	0	0
PIK3R5	23533	broad.mit.edu	37	17	8792128	8792128	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:8792128C>G	uc002glt.2	-	10	1043	c.976G>C	c.(976-978)GAG>CAG	p.E326Q	PIK3R5_uc010vuz.1_Missense_Mutation_p.E326Q|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.R274S|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	326				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						tcctcctcctcctcttcctcc	0.463	NSCLC(18;589 615 7696 20311 50332)		NA											10	19					0	0	0.006214	0	0
GAS7	8522	broad.mit.edu	37	17	9850262	9850262	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:9850262C>A	uc002gmg.1	-	6	725	c.564G>T	c.(562-564)CCG>CCT	p.P188P	GAS7_uc010vvc.1_Silent_p.P2P|GAS7_uc002gmh.1_Silent_p.P48P|GAS7_uc010vvd.1_Silent_p.P140P|GAS7_uc002gmi.2_Silent_p.P124P|GAS7_uc002gmj.1_Silent_p.P128P|GAS7_uc010coh.1_Silent_p.P128P	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	188					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						GCTGCTGTTCCGGCATCGTGT	0.572			NA	T	MLL	AML*								10	29					6.40141e-05	7.09722e-05	0.010729	1	0
MYH1	4619	broad.mit.edu	37	17	10399302	10399302	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:10399302C>T	uc002gmo.2	-	35	5228	c.5134G>A	c.(5134-5136)GAT>AAT	p.D1712N	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1712	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCACTGGCATCCAGGAGCTCC	0.517			NA											31	43					0	0	0.009535	0	0
MYH3	4621	broad.mit.edu	37	17	10544690	10544690	+	Splice_Site	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:10544690C>A	uc002gmq.1	-	17	2037	c.1960_splice	c.e17-1	p.E654_splice		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,						muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TCAGGTTTTCCTAAGAGAAAA	0.333			NA											30	65					1.80694e-10	2.49065e-10	0.009535	1	0
LLGL1	3996	broad.mit.edu	37	17	18145251	18145251	+	Silent	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:18145251G>C	uc002gsp.2	+	19	2881	c.2820G>C	c.(2818-2820)CGG>CGC	p.R940R		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	940					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					TAAGTGCCCGGAACATCACAG	0.572			NA											7	88					0	0	0.001984	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319603	21319603	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:21319603C>A	uc002gyv.1	+	3	1654	c.949C>A	c.(949-951)CTG>ATG	p.L317M		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	317	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CAGCTCCTACCTGGCCAATGA	0.582			NA								Prostate(3;0.18)			7	110					0.000157383	0.000170778	0.00308	1	0
ERAL1	26284	broad.mit.edu	37	17	27182086	27182086	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:27182086G>A	uc002hcy.1	+	1	44	c.34G>A	c.(34-36)GTT>ATT	p.V12I	ERAL1_uc002hcx.1_Missense_Mutation_p.V12I|ERAL1_uc002hcz.1_RNA|ERAL1_uc002hda.1_5'Flank|ERAL1_uc002hdb.1_5'Flank	NM_005702	NP_005693	O75616	ERAL1_HUMAN	Era-like 1	12					ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			skin(1)	1	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			GGCTAGGCTTGTTCAATCGGT	0.612			NA											12	33					0	0	0.001368	0	0
UNC45B	146862	broad.mit.edu	37	17	33497247	33497247	+	Silent	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:33497247C>G	uc002hja.2	+	12	1759	c.1662C>G	c.(1660-1662)GCC>GCG	p.A554A	UNC45B_uc002hjb.2_Silent_p.A554A|UNC45B_uc002hjc.2_Silent_p.A554A|UNC45B_uc010cto.2_Intron	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	554					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				ACGTCCCTGCCCTGCAGGCCA	0.627			NA											7	27					0	0	0.00308	0	0
ACACA	31	broad.mit.edu	37	17	35578665	35578665	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:35578665C>A	uc002hnm.2	-	29	3743	c.3552G>T	c.(3550-3552)CTG>CTT	p.L1184L	ACACA_uc002hnk.2_Silent_p.L1106L|ACACA_uc002hnl.2_Silent_p.L1126L|ACACA_uc002hnn.2_Silent_p.L1184L|ACACA_uc002hno.2_Silent_p.L1221L|ACACA_uc010cuz.2_Silent_p.L1184L	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1184					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAGATGTGGGCAGCATGAACT	0.473	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											12	46					6.40141e-05	7.09722e-05	0.010729	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274174	39274174	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:39274174G>T	uc002hvz.2	-	1	433	c.394C>A	c.(394-396)CCC>ACC	p.P132T		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	132	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].|22.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			cagcaggtgggctggcagcac	0.05			NA											10	21					1.08611e-07	1.38479e-07	0.010729	1	0
KRT34	3885	broad.mit.edu	37	17	39538481	39538481	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:39538481G>T	uc002hwm.2	-	1	156	c.144C>A	c.(142-144)TGC>TGA	p.C48*		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	48	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				GGCTGGGCAGGCAACAACTGT	0.632			NA											18	77					6.49762e-13	9.86246e-13	0.006122	1	0
SDK2	54549	broad.mit.edu	37	17	71391459	71391459	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr17:71391459C>A	uc010dfm.2	-	25	3427	c.3427G>T	c.(3427-3429)GGG>TGG	p.G1143W	SDK2_uc002jjt.3_Missense_Mutation_p.G302W|SDK2_uc010dfn.2_Missense_Mutation_p.G822W	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1143	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion	integral to membrane				ovary(2)	2						TTGCCATGCCCGTCTGACCGG	0.617			NA											10	29					1.76689e-08	2.32246e-08	0.006214	1	0
ZNF397	84307	broad.mit.edu	37	18	32823239	32823239	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr18:32823239T>C	uc010dmp.2	+	3	694	c.538T>C	c.(538-540)TGC>CGC	p.C180R	ZNF397_uc002kyi.2_Missense_Mutation_p.C180R|ZNF397_uc010dmq.2_Missense_Mutation_p.C180R|ZNF397_uc010dmr.2_RNA|ZNF397_uc002kyj.2_Missense_Mutation_p.C180R|ZNF397_uc002kyk.1_Missense_Mutation_p.C180R	NM_001135178	NP_001128650	Q8NF99	ZN397_HUMAN	zinc finger protein 397 isoform 1	180					viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTGGAAACCATGCCTTTCCCC	0.443			NA											23	68					0	0	0.00333	0	0
PIGN	23556	broad.mit.edu	37	18	59828461	59828461	+	Silent	SNP	T	T	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr18:59828461T>A	uc002lii.3	-	4	574	c.126A>T	c.(124-126)CCA>CCT	p.P42P	PIGN_uc002lij.3_Silent_p.P42P	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	42	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ATCTTCTCGCTGGAGGAGGCA	0.403			NA											9	28					0	0	0.006214	0	0
STK11	6794	broad.mit.edu	37	19	1220699	1220699	+	Missense_Mutation	SNP	G	G	T	rs137853082		TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:1220699G>T	uc002lrl.1	+	5	1832	c.717G>T	c.(715-717)TGG>TGT	p.W239C		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	239	Protein kinase.		W -> C (in PJS; late onset suggests reduced penetrance).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGACATCTGGTCGGCTGGGG	0.701			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			9	9					0.000673444	0.000712565	0.008291	1	0
OR1M1	125963	broad.mit.edu	37	19	9204166	9204166	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:9204166G>T	uc010xkj.1	+	1	246	c.246G>T	c.(244-246)CTG>CTT	p.L82L		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						CTAAGATGCTGGTGAGCCTTC	0.527			NA											18	28					0.000958276	0.00100975	0.007413	1	0
CYP4F8	11283	broad.mit.edu	37	19	15733988	15733988	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:15733988C>A	uc002nbi.2	+	9	785	c.721C>A	c.(721-723)CGG>AGG	p.R241R	CYP4F8_uc010xoj.1_Silent_p.R53R	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	241					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCAGTTCTTCCGGTACAAGGA	0.552			NA											16	29					1.3612e-06	1.6608e-06	0.003163	1	0
PIK3R2	5296	broad.mit.edu	37	19	18272854	18272854	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:18272854G>T	uc002nia.1	+	7	1406	c.894G>T	c.(892-894)GCG>GCT	p.A298A	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	298					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						AGGAGGTTGCGCCCCCAGGTG	0.607			NA											11	25					1.08611e-07	1.38479e-07	0.010729	1	0
ZNF737	100129842	broad.mit.edu	37	19	20727575	20727575	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:20727575C>A	uc002npa.2	-	4	1614	c.1434G>T	c.(1432-1434)GAG>GAT	p.E478D		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	478					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGTAGGGTTTCTCTCCAGTAT	0.413			NA											16	35					1.99824e-07	2.5101e-07	0.00499	1	0
ZNF492	57615	broad.mit.edu	37	19	22847646	22847646	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:22847646C>A	uc002nqw.3	+	4	1419	c.1175C>A	c.(1174-1176)CCC>CAC	p.P392H		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GGAGAGAAGCCCTACAAATGT	0.383			NA											8	41					3.86212e-05	4.31948e-05	0.008291	1	0
ZNF536	9745	broad.mit.edu	37	19	30936032	30936032	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:30936032C>A	uc002nsu.1	+	2	1701	c.1563C>A	c.(1561-1563)TAC>TAA	p.Y521*	ZNF536_uc010edd.1_Nonsense_Mutation_p.Y521*	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGAACAGCTACCAGGCTTGGC	0.607			NA											18	77					1.87028e-06	2.24963e-06	0.012319	1	0
ZNF223	7766	broad.mit.edu	37	19	44564659	44564659	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:44564659G>T	uc002oyf.1	+	3	320	c.67G>T	c.(67-69)GGG>TGG	p.G23W	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				GGAGGAGCTGGGGCTGCTGGA	0.517			NA											37	100					6.5261e-18	1.15566e-17	0.00874	1	0
ZNF285	26974	broad.mit.edu	37	19	44891421	44891421	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:44891421G>A	uc002ozd.3	-	4	1073	c.986C>T	c.(985-987)TCT>TTT	p.S329F	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.S336F	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	329	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						GTGAAGGGAAGAGCTGCGCCT	0.478			NA											25	52					0	0	0.00632	0	0
ZNF665	79788	broad.mit.edu	37	19	53668353	53668353	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:53668353C>G	uc010eqm.1	-	4	1490	c.1390G>C	c.(1390-1392)GGT>CGT	p.G464R		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	399	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		AAGACCTTACCGCAGTCATTA	0.438			NA											26	89					0	0	0.00333	0	0
BIRC8	112401	broad.mit.edu	37	19	53793228	53793228	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:53793228C>A	uc002qbk.2	-	1	1648	c.400G>T	c.(400-402)GAA>TAA	p.E134*		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	134					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		TGAATTCTTTCCTCCATTATT	0.368			NA											34	117					4.11147e-13	6.278e-13	0.003755	1	0
ZBTB45	84878	broad.mit.edu	37	19	59028554	59028554	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:59028554C>A	uc002qtd.2	-	2	779	c.487G>T	c.(487-489)GGG>TGG	p.G163W	ZBTB45_uc002qte.2_Missense_Mutation_p.G163W|ZBTB45_uc002qtf.2_Missense_Mutation_p.G163W	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	163	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		CCGGGGTGCCCCGGGGGACGT	0.736	NSCLC(164;1383 2017 5233 27540 46677)		NA									OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	34					4.14922e-12	6.18743e-12	0.004007	1	0
PXDN	7837	broad.mit.edu	37	2	1680744	1680744	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:1680744C>G	uc002qxa.2	-	8	867	c.803G>C	c.(802-804)AGA>ACA	p.R268T	PXDN_uc002qxb.1_Missense_Mutation_p.R268T|PXDN_uc002qxc.1_Missense_Mutation_p.R85T	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	268	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GCCTTCGGCTCTGCAGGTGAA	0.562			NA											11	13					0	0	0.008291	0	0
APOB	338	broad.mit.edu	37	2	21257763	21257763	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:21257763C>T	uc002red.2	-	8	957	c.829G>A	c.(829-831)GGG>AGG	p.G277R		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	277	Vitellogenin.|Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTACCATCCCATACTTATTC	0.448			NA											36	172					0	0	0.00623	0	0
FSHR	2492	broad.mit.edu	37	2	49190832	49190832	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:49190832G>T	uc002rww.2	-	10	1202	c.1128C>A	c.(1126-1128)GCC>GCA	p.A376A	FSHR_uc002rwx.2_Silent_p.A314A|FSHR_uc010fbn.2_Silent_p.A350A	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	376	Helical; Name=1; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCCCAGTGATGGCCAGGATGC	0.478			NA							Gonadal_Dysgenesis_46_XX				20	47					3.99206e-14	6.20716e-14	0.007413	1	0
WBP1	23559	broad.mit.edu	37	2	74687010	74687010	+	Silent	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:74687010G>C	uc002slj.1	+	3	336	c.183G>C	c.(181-183)CTG>CTC	p.L61L	WBP1_uc002slh.1_RNA|INO80B_uc002sli.1_RNA|WBP1_uc002slk.1_Silent_p.L58L|WBP1_uc002sll.1_RNA	NM_012477	NP_036609	Q96G27	WBP1_HUMAN	WW domain binding protein 1	61							WW domain binding				0						GGTTCTGGCTGCTCTGGACTG	0.572			NA											20	36					0	0	0.012319	0	0
INSIG2	51141	broad.mit.edu	37	2	118854157	118854157	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:118854157C>T	uc002tlk.2	+	2	231	c.25C>T	c.(25-27)CCT>TCT	p.P9S	INSIG2_uc010yye.1_Intron	NM_016133	NP_057217	Q9Y5U4	INSI2_HUMAN	insulin induced protein 2	9					ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex				ovary(1)|central_nervous_system(1)	2						GACAGAGTCACCTGGGCCCAA	0.418			NA											23	59					0	0	0.002299	0	0
UGGT1	56886	broad.mit.edu	37	2	128913089	128913089	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:128913089A>G	uc002tps.2	+	20	2342	c.2164A>G	c.(2164-2166)AGA>GGA	p.R722G	UGGT1_uc010fme.1_Missense_Mutation_p.R597G|UGGT1_uc002tpr.2_Missense_Mutation_p.R698G	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	722					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TGATTATGCTAGATTTACTAT	0.343			NA											15	53					0	0	0.00245	0	0
KCNH7	90134	broad.mit.edu	37	2	163256864	163256864	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:163256864C>A	uc002uch.1	-	10	2454	c.2242G>T	c.(2242-2244)GGG>TGG	p.G748W		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	748	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTACTTGCCCCCCGAAAGGCT	0.483	GBM(196;1492 2208 17507 24132 45496)		NA											23	70					9.95505e-16	1.59656e-15	0.002299	1	0
DNAH7	56171	broad.mit.edu	37	2	196750942	196750942	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:196750942C>A	uc002utj.3	-	34	5562	c.5461G>T	c.(5461-5463)GAC>TAC	p.D1821Y		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1821					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATAAAACAGTCTATTAGATTC	0.348			NA											14	50					2.61681e-11	3.81307e-11	0.00245	1	0
ANKRD44	91526	broad.mit.edu	37	2	197964625	197964625	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:197964625C>A	uc002uuc.2	-	10	1182	c.1015G>T	c.(1015-1017)GGC>TGC	p.G339C	ANKRD44_uc002utz.3_Missense_Mutation_p.G28C|ANKRD44_uc002uua.1_Missense_Mutation_p.G314C|ANKRD44_uc002uub.2_Missense_Mutation_p.G339C|ANKRD44_uc010zgw.1_Missense_Mutation_p.G267C	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	339	ANK 11.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GGAGTGTTGCCGTCCTTATCC	0.443			NA											17	53					3.32936e-07	4.1414e-07	0.006122	1	0
DOCK10	55619	broad.mit.edu	37	2	225739438	225739438	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:225739438C>A	uc010fwz.1	-	9	1201	c.962G>T	c.(961-963)TGC>TTC	p.C321F	DOCK10_uc002vob.2_Missense_Mutation_p.C315F|DOCK10_uc002vod.1_Missense_Mutation_p.C321F	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	321							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTCTGGCGTGCATTCACAAGT	0.363			NA											24	74					3.6726e-16	6.00329e-16	0.003954	1	0
NRSN2	80023	broad.mit.edu	37	20	333933	333933	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:333933T>C	uc002wdi.3	+	4	807	c.269T>C	c.(268-270)CTG>CCG	p.L90P	NRSN2_uc002wdj.2_RNA|NRSN2_uc002wdl.2_Intron	NM_024958	NP_079234	Q9GZP1	NRSN2_HUMAN	neurensin 2	90						integral to membrane|plasma membrane|transport vesicle					0		all_cancers(10;0.0834)				CCCCCCAAGCTGGAGGGCATC	0.647			NA											31	86					0	0	0.010818	0	0
ANGPT4	51378	broad.mit.edu	37	20	853683	853683	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:853683C>A	uc002wei.2	-	9	1535	c.1432G>T	c.(1432-1434)GGC>TGC	p.G478C	ANGPT4_uc010zpn.1_3'UTR	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	478	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						CAGCGGATGCCGTCCATCTTG	0.582	Pancreas(181;481 2077 3259 31286 49856)		NA											13	30					4.3838e-07	5.40033e-07	0.001855	1	0
PRND	23627	broad.mit.edu	37	20	4705533	4705533	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:4705533C>T	uc002wkz.2	+	2	407	c.336C>T	c.(334-336)ACC>ACT	p.T112T		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	112	Globular.				protein homooligomerization	anchored to membrane|plasma membrane					0						TCAATGCCACCCAGGCGGCGA	0.602			NA											12	41					0	0	0.010729	0	0
SNAP25	6616	broad.mit.edu	37	20	10277675	10277675	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:10277675C>A	uc002wnq.1	+	6	596	c.384C>A	c.(382-384)GCC>GCA	p.A128A	SNAP25_uc002wnr.1_Silent_p.A128A|SNAP25_uc002wns.1_Silent_p.A65A|SNAP25_uc010gca.1_Silent_p.A128A|SNAP25_uc010gcb.1_Silent_p.A65A|SNAP25_uc010gcc.1_Intron	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	128					energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	AGCAGATGGCCATCAGTGGCG	0.408			NA											9	42					3.07112e-06	3.64249e-06	0.010729	1	0
MYLK2	85366	broad.mit.edu	37	20	30408290	30408290	+	Silent	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:30408290A>T	uc002wwq.2	+	3	516	c.414A>T	c.(412-414)GCA>GCT	p.A138A		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	138					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCCAAGCAGCAGCCAGGAGGG	0.627			NA											16	29					0	0	0.004007	0	0
XKR7	343702	broad.mit.edu	37	20	30584986	30584986	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:30584986C>A	uc002wxe.2	+	3	1640	c.1466C>A	c.(1465-1467)GCG>GAG	p.A489E		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	489						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGGGCCTCGGCGGGAGAGCGT	0.701			NA											29	16					1.13719e-10	1.576e-10	0.008361	1	0
EMILIN3	90187	broad.mit.edu	37	20	39989924	39989924	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:39989924G>T	uc002xjy.1	-	4	2509	c.2285C>A	c.(2284-2286)CCA>CAA	p.P762Q		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	762						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				GGCTTGCCCTGGCCGCACCTG	0.647			NA											7	9					0.00198382	0.00207325	0.001984	1	0
R3HDML	140902	broad.mit.edu	37	20	42965887	42965887	+	Silent	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:42965887C>G	uc002xls.1	+	1	262	c.90C>G	c.(88-90)ACC>ACG	p.T30T		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	30						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CTAATGCTACCCCAGCCCCGG	0.652			NA											27	20					0	0	0.007291	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514537	58514537	+	Silent	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:58514537G>A	uc002ybb.2	-	1	816	c.450C>T	c.(448-450)TTC>TTT	p.F150F	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	150					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			AATGCAGGGTGAACTCCAGGT	0.672			NA											8	22					0	0	0.00308	0	0
DIDO1	11083	broad.mit.edu	37	20	61511339	61511339	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr20:61511339C>T	uc002ydr.1	-	16	6233	c.5969G>A	c.(5968-5970)GGT>GAT	p.G1990D	DIDO1_uc002yds.1_Missense_Mutation_p.G1990D	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1990	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCGTAGTCCACCAAACTGCAG	0.597	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											71	152					0	0	0.00361	0	0
PKNOX1	5316	broad.mit.edu	37	21	44438272	44438272	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr21:44438272G>T	uc002zcq.1	+	7	840	c.652G>T	c.(652-654)GTC>TTC	p.V218F	PKNOX1_uc002zcp.1_Missense_Mutation_p.V218F|PKNOX1_uc011aex.1_Missense_Mutation_p.V101F	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	218							sequence-specific DNA binding			large_intestine(2)	2						TGTCACGGTCGTCACTCCCCA	0.468			NA											13	30					2.98522e-18	5.36078e-18	0.003163	1	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047872	46047872	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr21:46047872T>A	uc002zfp.3	+	1	833	c.784T>A	c.(784-786)TGC>AGC	p.C262S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	262						keratin filament					0						GCCCAGCTATTGCCGCCAGGC	0.692			NA											28	79					0	0	0.007291	0	0
ADARB1	104	broad.mit.edu	37	21	46603320	46603320	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr21:46603320C>T	uc002zgy.2	+	7	1726	c.1291C>T	c.(1291-1293)CGA>TGA	p.R431*	ADARB1_uc002zgr.2_Nonsense_Mutation_p.R431*|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Nonsense_Mutation_p.R431*|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Nonsense_Mutation_p.R431*|ADARB1_uc010gpx.2_RNA|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	431	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		GAAATCAGAGCGAGGGGGGTT	0.393			NA											4	30					0	0	0.009096	0	0
POTEH	23784	broad.mit.edu	37	22	16287667	16287667	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr22:16287667C>T	uc010gqp.2	-	1	271	c.219G>A	c.(217-219)AGG>AGA	p.R73R	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	73										skin(1)	1						TGCCGCTCCCCCTGCACCAGG	0.577			NA											59	288					0	0	0.00361	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869678	22869678	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr22:22869678C>A	uc002zwe.2	-	2	530	c.277G>T	c.(277-279)GTG>TTG	p.V93L	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	93					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ATAGAGGTCACATGATTTGCA	0.468			NA											24	79					1.1804e-14	1.88126e-14	0.003954	1	0
SEC14L4	284904	broad.mit.edu	37	22	30886131	30886131	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr22:30886131T>G	uc003aid.2	-	12	1284	c.1184A>C	c.(1183-1185)CAG>CCG	p.Q395P	SEC14L4_uc011akz.1_Intron|SEC14L4_uc003aie.2_Missense_Mutation_p.Q380P|SEC14L4_uc003aif.2_Silent_p.R356R	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	395						integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	CTTGAGACTCTGCAGCGTCTC	0.607			NA											7	21					0	0	0.004482	0	0
MYLK	4638	broad.mit.edu	37	3	123419547	123419547	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr3:123419547A>G	uc003ego.2	-	18	3050	c.2768T>C	c.(2767-2769)ATG>ACG	p.M923T	MYLK_uc011bjw.1_Missense_Mutation_p.M923T|MYLK_uc003egp.2_Missense_Mutation_p.M854T|MYLK_uc003egq.2_Missense_Mutation_p.M923T|MYLK_uc003egr.2_Missense_Mutation_p.M854T|MYLK_uc003egs.2_Missense_Mutation_p.M747T|MYLK_uc003egt.2_Missense_Mutation_p.M114T	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	923	1-2.|Actin-binding (calcium/calmodulin- sensitive) (By similarity).|5 X 28 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACGGAAATCCATCTGCTCGGC	0.572			NA											19	34					0	0	0.010504	0	0
SI	6476	broad.mit.edu	37	3	164780204	164780204	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr3:164780204G>T	uc003fei.2	-	9	1037	c.975C>A	c.(973-975)ATC>ATA	p.I325I		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	325	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTCCTAGAAGGATGTAAAAAT	0.313			NA								HNSCC(35;0.089)			13	40					6.72482e-11	9.4742e-11	0.003163	1	0
NLGN1	22871	broad.mit.edu	37	3	173997044	173997044	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr3:173997044T>G	uc003fio.1	+	6	1676	c.1253T>G	c.(1252-1254)TTT>TGT	p.F418C	NLGN1_uc010hww.1_Missense_Mutation_p.F458C|NLGN1_uc003fip.1_Missense_Mutation_p.F418C	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	435	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTTTCAAATTTTGTTGATAAT	0.358			NA											21	29					0	0	0.00333	0	0
UTS2D	257313	broad.mit.edu	37	3	190993099	190993099	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr3:190993099C>A	uc003fsu.2	-	8	1063	c.276G>T	c.(274-276)AAG>AAT	p.K92N		NM_198152	NP_937795	Q765I0	UTS2B_HUMAN	urotensin 2 domain containing precursor	92						extracellular region	hormone activity				0	all_cancers(143;1.77e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000214)		TCTCAGAATCCTTCTCCTCCA	0.338			NA											50	57					9.22156e-22	1.75485e-21	0.00361	1	0
SH3BP2	6452	broad.mit.edu	37	4	2834061	2834061	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:2834061G>T	uc003gfi.3	+	11	1530	c.1410G>T	c.(1408-1410)TTG>TTT	p.L470F	SH3BP2_uc011bvp.1_Missense_Mutation_p.L498F|SH3BP2_uc003gfj.3_Missense_Mutation_p.L527F|SH3BP2_uc003gfk.3_Missense_Mutation_p.L470F|SH3BP2_uc003gfl.3_Missense_Mutation_p.L403F|SH3BP2_uc003gfm.3_Missense_Mutation_p.L445F	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	470	SH2.				signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		ATTTTAGGTTGTTCAAGGCTA	0.592			NA							Cherubism				62	93					1.55545e-33	3.05107e-33	0.00361	1	0
TBC1D14	57533	broad.mit.edu	37	4	7006648	7006648	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:7006648G>T	uc011bwg.1	+	8	1427	c.1348G>T	c.(1348-1350)GAA>TAA	p.E450*	TBC1D14_uc003gjs.3_Nonsense_Mutation_p.E450*|TBC1D14_uc010idh.2_Nonsense_Mutation_p.E170*|TBC1D14_uc011bwh.1_Nonsense_Mutation_p.E63*|TBC1D14_uc003gju.3_5'UTR	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	450	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						AGTGGAGAACGAAGGTAGAAT	0.458			NA											23	50					1.55795e-14	2.46755e-14	0.012319	1	0
SLIT2	9353	broad.mit.edu	37	4	20493522	20493522	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:20493522T>C	uc003gpr.1	+	9	1118	c.914T>C	c.(913-915)ATA>ACA	p.I305T	SLIT2_uc003gps.1_Missense_Mutation_p.I305T	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	305	LRR 7.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATCACAGAAATGTATGTGCCT	0.458			NA											23	103					0	0	0.00333	0	0
ARAP2	116984	broad.mit.edu	37	4	36230472	36230472	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:36230472C>A	uc003gsq.1	-	2	975	c.637G>T	c.(637-639)GAC>TAC	p.D213Y	ARAP2_uc003gsr.1_Missense_Mutation_p.D213Y	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	213					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CATTCAGAGTCTGCATTAGGG	0.368			NA											79	99					1.42074e-37	2.83038e-37	0.00361	1	0
LPHN3	23284	broad.mit.edu	37	4	62935842	62935842	+	Missense_Mutation	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:62935842A>G	uc010ihh.2	+	23	3799	c.3626A>G	c.(3625-3627)AAT>AGT	p.N1209S	LPHN3_uc003hcq.3_Silent_p.Q1226Q|LPHN3_uc003hct.2_Missense_Mutation_p.N593S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1187	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CTTCTGAACAATGCCAGGGAT	0.413			NA											28	40					0	0	0.009535	0	0
FSTL5	56884	broad.mit.edu	37	4	162421230	162421230	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:162421230G>T	uc003iqh.2	-	12	1832	c.1396C>A	c.(1396-1398)CAA>AAA	p.Q466K	FSTL5_uc003iqi.2_Missense_Mutation_p.Q465K|FSTL5_uc010iqv.2_Missense_Mutation_p.Q456K	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	466						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCTATGGGTTGTATCACTTTG	0.328			NA											7	30					0.000157383	0.000170778	0.00308	1	0
ODZ3	55714	broad.mit.edu	37	4	183713936	183713936	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:183713936G>T	uc003ivd.1	+	25	6148	c.6111G>T	c.(6109-6111)ACG>ACT	p.T2037T		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2037	YD 13.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCAATGAAACGCCACTGCCTA	0.383			NA											19	89					8.10497e-08	1.05447e-07	0.010504	1	0
SNX25	83891	broad.mit.edu	37	4	186272671	186272671	+	Missense_Mutation	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:186272671C>G	uc003ixh.2	+	14	2071	c.1882C>G	c.(1882-1884)CTC>GTC	p.L628V	SNX25_uc010ish.2_Intron|SNX25_uc003ixi.2_Missense_Mutation_p.L132V	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	628	PX.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TCCTGACTACCTCAAGGTTAT	0.448			NA											28	91					0	0	0.004656	0	0
FAT1	2195	broad.mit.edu	37	4	187584546	187584546	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:187584546C>A	uc003izf.2	-	3	3675	c.3487G>T	c.(3487-3489)GCA>TCA	p.A1163S		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1163	Extracellular (Potential).|Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ggatcaaatgcctcgatctgg	0.244	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			17	55					5.3912e-06	6.2489e-06	0.006122	1	0
TRIML1	339976	broad.mit.edu	37	4	189063558	189063558	+	Silent	SNP	C	C	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:189063558C>G	uc003izm.1	+	3	772	c.657C>G	c.(655-657)ACC>ACG	p.T219T	TRIML1_uc003izn.1_5'Flank	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	219	Potential.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TCAAACTGACCCAGCAAATCA	0.453	Melanoma(31;213 1036 16579 23968 32372)		NA											12	35					0	0	0.001855	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	182169	182169	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:182169C>A	uc003jak.2	+	18	3597	c.3547C>A	c.(3547-3549)CCC>ACC	p.P1183T		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1183	Ser-rich.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CCACGCCGCCCCCTTCAAGCG	0.607			NA											29	105					4.2108e-06	4.92548e-06	0.009535	1	0
SLC1A3	6507	broad.mit.edu	37	5	36679962	36679962	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:36679962G>T	uc003jkj.3	+	7	1570	c.1094G>T	c.(1093-1095)AGT>ATT	p.S365I	SLC1A3_uc011cox.1_Missense_Mutation_p.S258I|SLC1A3_uc010iuy.2_Missense_Mutation_p.S365I	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	365					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	ACCTCTTCAAGGTATGTATGT	0.453			NA											28	19					2.41591e-17	4.16255e-17	0.004656	1	0
MAP1B	4131	broad.mit.edu	37	5	71491582	71491582	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:71491582C>A	uc003kbw.3	+	5	2641	c.2400C>A	c.(2398-2400)GGC>GGA	p.G800G	MAP1B_uc010iyw.1_Silent_p.G817G|MAP1B_uc010iyx.1_Silent_p.G674G|MAP1B_uc010iyy.1_Silent_p.G674G	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	800						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CAGCTGTCGGCACTGGAGCCA	0.542	Melanoma(17;367 822 11631 31730 47712)		NA											20	28					1.9806e-07	2.5101e-07	0.002299	1	0
SLCO4C1	353189	broad.mit.edu	37	5	101592825	101592825	+	Missense_Mutation	SNP	T	T	G	rs143134834		TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:101592825T>G	uc003knm.2	-	8	1750	c.1463A>C	c.(1462-1464)TAT>TCT	p.Y488S		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	488	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TTACCCATTATATGATTCAGA	0.333			NA											13	25					0	0	0.001368	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751709	140751709	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:140751709A>T	uc003ljw.1	+	1	1748	c.1748A>T	c.(1747-1749)GAG>GTG	p.E583V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.E583V|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	583	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTCTGCAGAGCCTGGCTAC	0.647			NA											19	34					0	0	0.007413	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764230	140764230	+	Silent	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:140764230G>C	uc003lka.1	+	1	1764	c.1764G>C	c.(1762-1764)GTG>GTC	p.V588V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.V588V	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	588	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTACCTGGTGACCAAGGTGG	0.622			NA											25	48					0	0	0.00278	0	0
DPYSL3	1809	broad.mit.edu	37	5	146780281	146780281	+	Missense_Mutation	SNP	T	T	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:146780281T>G	uc003lon.1	-	10	1194	c.1084A>C	c.(1084-1086)ATG>CTG	p.M362L	DPYSL3_uc003loo.2_Missense_Mutation_p.M476L	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	362					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAGACATCCGCTCCTCC	0.567			NA											18	27					0	0	0.006122	0	0
NMUR2	56923	broad.mit.edu	37	5	151771964	151771964	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:151771964G>T	uc003luv.2	-	4	1202	c.1036C>A	c.(1036-1038)CAC>AAC	p.H346N		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	346	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CACTGTTTGTGGAAAGAAGAG	0.512			NA											30	42					5.77227e-19	1.04392e-18	0.008361	1	0
TIMD4	91937	broad.mit.edu	37	5	156381546	156381546	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:156381546C>A	uc003lwh.2	-	2	337	c.280G>T	c.(280-282)GAT>TAT	p.D94Y	TIMD4_uc010jii.2_Missense_Mutation_p.D94Y	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	94	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAGGAGACATCACCTCTCGGG	0.502			NA											23	25					3.5997e-14	5.63143e-14	0.002299	1	0
ITK	3702	broad.mit.edu	37	5	156649936	156649936	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:156649936C>A	uc003lwo.1	+	6	641	c.559C>A	c.(559-561)CCT>ACT	p.P187T		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	187	SH3.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AACCAATGATCCTCAGGAACT	0.488	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								24	32					9.57634e-11	1.33441e-10	0.00333	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178634669	178634669	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr5:178634669G>T	uc003mjw.2	-	4	736	c.736C>A	c.(736-738)CTA>ATA	p.L246I	ADAMTS2_uc011dgm.1_Missense_Mutation_p.L246I	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	246					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGCTCCTCTAGGACGCCCAGG	0.657			NA											19	61					2.4624e-09	3.33995e-09	0.008871	1	0
TRIM39	56658	broad.mit.edu	37	6	30303750	30303750	+	Missense_Mutation	SNP	A	A	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:30303750A>C	uc010jrz.2	+	5	1090	c.778A>C	c.(778-780)AAG>CAG	p.K260Q	TRIM39_uc003npz.2_Missense_Mutation_p.K260Q|TRIM39_uc003nqb.2_Missense_Mutation_p.K260Q|TRIM39_uc003nqc.2_Missense_Mutation_p.K260Q|TRIM39_uc010jsa.1_Missense_Mutation_p.K260Q	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	260					apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						CGAGATGCTTAAGGTTCGACC	0.582			NA											10	28					0	0	0.006214	0	0
COL11A2	1302	broad.mit.edu	37	6	33156932	33156932	+	Missense_Mutation	SNP	A	A	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:33156932A>T	uc003ocx.1	-	3	494	c.266T>A	c.(265-267)GTT>GAT	p.V89D	COL11A2_uc003ocy.1_Missense_Mutation_p.V89D|COL11A2_uc003ocz.1_Missense_Mutation_p.V89D|COL11A2_uc003oda.2_Missense_Mutation_p.V89D	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	89	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGTCCGGACAACAGTCAGCAG	0.597	Melanoma(1;90 116 3946 5341 17093)		NA											19	25					0	0	0.007413	0	0
PGC	5225	broad.mit.edu	37	6	41712181	41712181	+	Silent	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:41712181G>A	uc003ora.1	-	3	331	c.282C>T	c.(280-282)TCC>TCT	p.S94S		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	94					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			ACAAGTTGGAGGAGCCGGTGT	0.602			NA											21	51					0	0	0.012319	0	0
OPN5	221391	broad.mit.edu	37	6	47775959	47775959	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:47775959G>C	uc003ozc.2	+	5	831	c.826G>C	c.(826-828)GCT>CCT	p.A276P	OPN5_uc003ozd.2_Missense_Mutation_p.A111P	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	276	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						TGTGTGGTCAGCTTTTGGAAG	0.463	Melanoma(28;740 973 10870 42660 45347)		NA											36	102					0	0	0.003271	0	0
CRISP3	10321	broad.mit.edu	37	6	49704164	49704164	+	Silent	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:49704164C>A	uc003ozs.2	-	3	144	c.129G>T	c.(127-129)GTG>GTT	p.V43V		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	43					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TGTGCTTATTCACAATCTCCC	0.413			NA											56	144					2.12129e-23	4.09794e-23	0.00361	1	0
GSTA5	221357	broad.mit.edu	37	6	52699031	52699031	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:52699031G>C	uc003pba.1	-	5	392	c.322C>G	c.(322-324)CTT>GTT	p.L108V		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	108	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	ATGAGCAGAAGAAGGATCATT	0.368			NA											47	114					0	0	0.013114	0	0
C6orf142	90523	broad.mit.edu	37	6	53883845	53883845	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:53883845G>T	uc003pcg.3	+	1	132	c.19G>T	c.(19-21)GAA>TAA	p.E7*	C6orf142_uc003pcf.2_Nonsense_Mutation_p.E7*	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	7	Interaction with LMNA.					nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					TGAAAAGCGTGAAAAAAGAAG	0.358			NA											7	34					8.12818e-05	8.934e-05	0.001984	1	0
HMGCLL1	54511	broad.mit.edu	37	6	55360355	55360355	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:55360355G>T	uc003pcn.2	-	8	906	c.747C>A	c.(745-747)GAC>GAA	p.D249E	HMGCLL1_uc003pco.2_Missense_Mutation_p.D219E|HMGCLL1_uc010jzx.2_Missense_Mutation_p.D120E|HMGCLL1_uc011dxc.1_Missense_Mutation_p.D187E|HMGCLL1_uc011dxd.1_Missense_Mutation_p.D116E|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	249							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTCCAATTGTGTCTCCTAGAG	0.413	Ovarian(35;840 893 7837 15538 42887)		NA											24	31					4.7796e-09	6.44867e-09	0.004656	1	0
BAI3	577	broad.mit.edu	37	6	69685223	69685223	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:69685223G>T	uc003pev.3	+	10	2173	c.1725G>T	c.(1723-1725)TTG>TTT	p.L575F	BAI3_uc010kak.2_Missense_Mutation_p.L575F	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	575	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ACAGACACTTGCAGCATTCAG	0.443			NA											12	39					9.31168e-06	1.06479e-05	0.001855	1	0
SFRS18	25957	broad.mit.edu	37	6	99856015	99856015	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:99856015T>C	uc003ppo.3	-	7	1034	c.806A>G	c.(805-807)AAG>AGG	p.K269R	SFRS18_uc003ppp.3_Missense_Mutation_p.K269R|SFRS18_uc011eag.1_Missense_Mutation_p.K269R|SFRS18_uc003ppr.2_Missense_Mutation_p.K269R	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	269	Potential.					nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TTCTGTGGCCTTTTTTTCTTT	0.393			NA											38	75					0	0	0.00623	0	0
ASCC3	10973	broad.mit.edu	37	6	101075568	101075568	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:101075568G>A	uc003pqk.2	-	29	4869	c.4540C>T	c.(4540-4542)CGA>TGA	p.R1514*		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		ACTGATGGTCGGAAGTTAAAC	0.363			NA											8	27					0	0	0.008291	0	0
GRIK2	2898	broad.mit.edu	37	6	102247541	102247541	+	Missense_Mutation	SNP	T	T	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:102247541T>A	uc003pqp.3	+	7	1219	c.970T>A	c.(970-972)TAT>AAT	p.Y324N	GRIK2_uc003pqn.2_Missense_Mutation_p.Y324N|GRIK2_uc003pqo.3_Missense_Mutation_p.Y324N|GRIK2_uc010kcw.2_Missense_Mutation_p.Y324N	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	324	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGCTCTAATGTATGATGCTGT	0.458			NA											37	87					0	0	0.00874	0	0
GSTM2P1	442245	broad.mit.edu	37	6	111368258	111368258	+	Missense_Mutation	SNP	A	A	G	rs112652573		TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:111368258A>G	uc003puq.2	-	1	500	c.365T>C	c.(364-366)GTG>GCG	p.V122A		NR_002932				Homo sapiens chromosome 1 truncated glutathione S-transferase M1 mRNA, complete cds.												0						GATGAAATCCACAAGTGTGAT	0.493			NA											13	38					0	0	0.001855	0	0
THEMIS	387357	broad.mit.edu	37	6	128176268	128176268	+	Missense_Mutation	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:128176268C>T	uc003qbi.2	-	3	476	c.157G>A	c.(157-159)GGT>AGT	p.G53S	THEMIS_uc010kfa.2_5'UTR|THEMIS_uc011ebt.1_Missense_Mutation_p.G53S|THEMIS_uc010kfb.2_Missense_Mutation_p.G18S	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	53	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						ACTTTGAGACCAGTAATTTTA	0.338			NA											14	25					0	0	0.001855	0	0
TAAR6	319100	broad.mit.edu	37	6	132892437	132892437	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:132892437T>C	uc011eck.1	+	1	977	c.977T>C	c.(976-978)GTA>GCA	p.V326A		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	326	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		AAAGTTATTGTAACTGGTCAG	0.318			NA											38	70					0	0	0.003755	0	0
THBS2	7058	broad.mit.edu	37	6	169648565	169648565	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:169648565C>A	uc003qwt.2	-	4	804	c.556G>T	c.(556-558)GAA>TAA	p.E186*		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	186	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CGGCTCTTTTCCGCCTGCAGG	0.617	Esophageal Squamous(91;219 1934 18562 44706)		NA											39	84					2.19358e-23	4.20574e-23	0.005524	1	0
HOXA2	3199	broad.mit.edu	37	7	27140486	27140486	+	Silent	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:27140486T>C	uc003syh.2	-	2	1265	c.990A>G	c.(988-990)ACA>ACG	p.T330T		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	330						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GGCAGGAATCTGTGGAGAAAA	0.502			NA											26	30					0	0	0.003954	0	0
HOXA7	3204	broad.mit.edu	37	7	27194740	27194740	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:27194740T>C	uc003sys.2	-	2	613	c.481A>G	c.(481-483)ATT>GTT	p.I161V	HOXA6_uc003syq.1_5'Flank|uc003syr.1_3'UTR	NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	161	Homeobox.				angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						GCGATTTCAATGCGGCGGCGC	0.607			NA											38	74					0	0	0.007835	0	0
ZNF716	441234	broad.mit.edu	37	7	57529162	57529162	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:57529162C>A	uc011kdi.1	+	4	1107	c.995C>A	c.(994-996)GCC>GAC	p.A332D		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TGTGGCAAAGCCTTTAGCTTA	0.418			NA											13	13					1.05317e-09	1.43614e-09	0.00245	1	0
ABCB1	5243	broad.mit.edu	37	7	87168583	87168583	+	Splice_Site	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:87168583C>A	uc003uiz.1	-	20	2815	c.2397_splice	c.e20+1	p.Q799_splice	ABCB1_uc011khc.1_Splice_Site_p.Q735_splice	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1						G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GATAGACATACCTGTCTGAGC	0.542			NA											8	20					2.17888e-05	2.46939e-05	0.006214	1	0
LRGUK	136332	broad.mit.edu	37	7	133824234	133824234	+	Silent	SNP	C	C	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:133824234C>T	uc003vrm.1	+	3	467	c.451C>T	c.(451-453)CTA>TTA	p.L151L		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	151	LRR 2.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						ATATGTTCATCTACAGAAGTT	0.318			NA											13	35					0	0	0.004007	0	0
BRAF	673	broad.mit.edu	37	7	140481402	140481402	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:140481402C>A	uc003vwc.3	-	11	1467	c.1406G>T	c.(1405-1407)GGA>GTA	p.G469V		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	469	ATP (By similarity).|Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469A(19)|p.G469V(12)|p.G469S(6)|p.G469R(6)|p.G469E(5)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGACTGTTCCAAATGATCC	0.373	Colon(40;35 892 2973 5743 27438)	G469A(NCIH1395_LUNG)|G469A(NCIH1755_LUNG)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				34	77					6.97489e-18	1.21822e-17	0.004878	1	0
MLL3	58508	broad.mit.edu	37	7	151945057	151945057	+	Missense_Mutation	SNP	G	G	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr7:151945057G>A	uc003wla.2	-	14	2681	c.2462C>T	c.(2461-2463)CCA>CTA	p.P821L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	821					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCCAATTTTTGGAGTGACTGA	0.413	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								20	226					0	0	0.007413	0	0
ERICH1	157697	broad.mit.edu	37	8	623844	623844	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:623844G>C	uc003wph.2	-	4	573	c.508C>G	c.(508-510)CAA>GAA	p.Q170E	ERICH1_uc011kwh.1_Missense_Mutation_p.Q170E|ERICH1_uc003wpe.1_Missense_Mutation_p.Q76E|ERICH1_uc003wpi.2_5'UTR	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	170										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CTTTTAATTTGCTGTTTCTTT	0.468			NA											11	65					0	0	0.010729	0	0
PURG	29942	broad.mit.edu	37	8	30889896	30889896	+	Silent	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:30889896G>T	uc003xin.2	-	1	422	c.403C>A	c.(403-405)CGG>AGG	p.R135R	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Silent_p.R135R	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	135	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		TGCTCTTGCCGGTGGCCTTTC	0.597			NA											36	108					2.6416e-12	3.9624e-12	0.00623	1	0
CHRNB3	1142	broad.mit.edu	37	8	42591742	42591742	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:42591742G>T	uc003xpi.1	+	6	1486	c.1358G>T	c.(1357-1359)TGG>TTG	p.W453L		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	453					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TTGAAGATGTGGCTACATAGT	0.398			NA											32	125					2.20474e-14	3.47042e-14	0.003755	1	0
FNTA	2339	broad.mit.edu	37	8	42914258	42914258	+	Missense_Mutation	SNP	T	T	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:42914258T>C	uc003xps.2	+	2	272	c.224T>C	c.(223-225)ATA>ACA	p.I75T	FNTA_uc003xpt.2_Intron|FNTA_uc003xpu.2_Intron|FNTA_uc003xpv.2_Intron	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	75					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TGGGCTGATATAGATCCGGTG	0.403			NA											11	19					0	0	0.003163	0	0
PXDNL	137902	broad.mit.edu	37	8	52252232	52252232	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:52252232G>T	uc003xqu.3	-	21	4199	c.4098C>A	c.(4096-4098)AGC>AGA	p.S1366R	PXDNL_uc003xqt.3_Intron	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1366					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGCAAACGTGCTGAAATCTT	0.378			NA											24	73					5.35356e-11	7.58421e-11	0.00278	1	0
RP1	6101	broad.mit.edu	37	8	55542556	55542556	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:55542556C>A	uc003xsd.1	+	4	6262	c.6114C>A	c.(6112-6114)CAC>CAA	p.H2038Q	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2038					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATTTCTTGCACACATCATTGT	0.333	Colon(91;1014 1389 7634 14542 40420)		NA											16	57					5.03518e-11	7.17303e-11	0.007413	1	0
KCNB2	9312	broad.mit.edu	37	8	73848519	73848519	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:73848519G>C	uc003xzb.2	+	3	1517	c.929G>C	c.(928-930)AGG>ACG	p.R310T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	310	Helical; Voltage-sensor; Name=Segment S4; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CGCATCCTCAGGATCCTGAAA	0.512			NA											22	50					0	0	0.002299	0	0
OSR2	116039	broad.mit.edu	37	8	99961644	99961644	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr8:99961644C>A	uc003yir.2	+	2	999	c.464C>A	c.(463-465)CCG>CAG	p.P155Q	OSR2_uc010mbn.2_Missense_Mutation_p.P155Q|OSR2_uc003yiq.2_Missense_Mutation_p.P155Q|OSR2_uc011lgx.1_Missense_Mutation_p.P276Q	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	155					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			AAATTGACTCCGGACAGAAAG	0.532			NA											32	129					4.3181e-19	7.86511e-19	0.002836	1	0
JAK2	3717	broad.mit.edu	37	9	5050756	5050756	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr9:5050756G>C	uc010mhm.2	+	5	652	c.539G>C	c.(538-540)GGG>GCG	p.G180A	JAK2_uc003ziw.2_Missense_Mutation_p.G180A	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	180	Interaction with cytokine/interferon/growth hormone receptors (By similarity).|FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GAATGTCTTGGGATGGCAGTG	0.388			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				19	33					0	0	0.007413	0	0
GAPVD1	26130	broad.mit.edu	37	9	128094322	128094322	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr9:128094322G>T	uc010mwx.2	+	14	2617	c.2291G>T	c.(2290-2292)GGC>GTC	p.G764V	GAPVD1_uc011lzs.1_Missense_Mutation_p.G764V|GAPVD1_uc004bpp.2_Missense_Mutation_p.G764V|GAPVD1_uc004bpq.2_Missense_Mutation_p.G764V|GAPVD1_uc004bpr.2_Missense_Mutation_p.G743V|GAPVD1_uc004bps.2_Missense_Mutation_p.G764V|GAPVD1_uc010mwy.1_Missense_Mutation_p.G623V	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	764					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGCACACCAGGCCTCAGTGTT	0.507			NA											7	11					0.00198382	0.00207325	0.001984	1	0
HDAC6	10013	broad.mit.edu	37	X	48661577	48661577	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrX:48661577G>T	uc011mmi.1	+	4	360	c.265G>T	c.(265-267)GTG>TTG	p.V89L	HDAC6_uc004dkr.1_Missense_Mutation_p.V89L|HDAC6_uc004dks.1_Missense_Mutation_p.V89L|HDAC6_uc010nig.1_5'UTR|HDAC6_uc004dkt.1_Missense_Mutation_p.V89L|HDAC6_uc004dku.3_Missense_Mutation_p.V89L|HDAC6_uc011mmj.1_Missense_Mutation_p.V34L|HDAC6_uc011mmk.1_Missense_Mutation_p.V70L	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	89	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	CACTGGCTTGGTGTTGGATGA	0.488	Pancreas(112;205 1675 2305 8976 15959)		NA											9	2					0.000673444	0.000712565	0.008291	1	0
XAGE5	170627	broad.mit.edu	37	X	52844156	52844156	+	Silent	SNP	A	A	G			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrX:52844156A>G	uc004drd.1	+	4	284	c.219A>G	c.(217-219)TCA>TCG	p.S73S		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	73								p.S73*(1)		ovary(1)	1						TGTCTCAGTCAAAGACTGGGG	0.443			NA											12	9					0	0	0.010729	0	0
ATP7A	538	broad.mit.edu	37	X	77298209	77298209	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrX:77298209G>T	uc004ecx.3	+	20	4088	c.3928G>T	c.(3928-3930)GCA>TCA	p.A1310S		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1310	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						CCCAGCTCTGGCAATGGCTAA	0.478			NA											66	46					6.52717e-41	1.32097e-40	0.00361	1	0
KLHL4	56062	broad.mit.edu	37	X	86869526	86869526	+	Missense_Mutation	SNP	G	G	C			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrX:86869526G>C	uc004efb.2	+	3	862	c.680G>C	c.(679-681)GGA>GCA	p.G227A	KLHL4_uc004efa.2_Missense_Mutation_p.G227A	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	227	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGGATGGAAGGAGTAGATCCA	0.398			NA											26	10					0	0	0.003954	0	0
SPRY3	10251	broad.mit.edu	37	X	155003948	155003948	+	Missense_Mutation	SNP	C	C	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrX:155003948C>A	uc004fnq.1	+	2	869	c.415C>A	c.(415-417)CAC>AAC	p.H139N	SPRY3_uc010nvl.1_Intron	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	139					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATCTGCAGGGCACCCTAGTGA	0.602			NA											38	69					1.03484e-13	1.58966e-13	0.005524	1	0
PRKY	5616	broad.mit.edu	37	Y	7193996	7193996	+	Missense_Mutation	SNP	G	G	T			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrY:7193996G>T	uc004fre.2	+	3	725	c.385G>T	c.(385-387)GTG>TTG	p.V129L		NM_002760	NP_002751			RecName: Full=Serine/threonine-protein kinase PRKX;          EC=2.7.11.1; AltName: Full=Protein kinase PKX1;												0						CATGGAGTATGTGCCGGGTGG	0.622			NA											21	8					7.41877e-09	9.90464e-09	0.012319	1	0
CRB1	23418	broad.mit.edu	37	1	197390533	197390533	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:197390533delC	uc001gtz.2	+	6	1710	c.1575delC	c.(1573-1575)TTCfs	p.F525fs	CRB1_uc010poz.1_Frame_Shift_Del_p.F456fs|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Frame_Shift_Del_p.F413fs|CRB1_uc010ppb.1_Frame_Shift_Del_p.F525fs|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Frame_Shift_Del_p.F6fs|CRB1_uc001gub.1_Frame_Shift_Del_p.F174fs	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	525	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TTCTACTTTTCCGAAGCAACA	0.453			NA											40	86	---	---	---	---	NA	NA	NA	NA	NA
FAM177B	400823	broad.mit.edu	37	1	222923324	222923324	+	Frame_Shift_Del	DEL	A	A	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr1:222923324delA	uc001hnt.2	+	6	667	c.401delA	c.(400-402)GAAfs	p.E134fs	uc001hnr.1_Intron|FAM177B_uc009xeb.2_RNA	NM_207468	NP_997351	A6PVY3	F177B_HUMAN	hypothetical protein LOC400823	134										ovary(1)	1						GTTCCTAATGAAAAGTGTCAC	0.463			NA											24	37	---	---	---	---	NA	NA	NA	NA	NA
ZNF71	58491	broad.mit.edu	37	19	57132833	57132834	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr19:57132833_57132834insA	uc002qnm.3	+	3	416_417	c.178_179insA	c.(178-180)GGAfs	p.G60fs		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	60						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGAGCCATTGGGAATTCCCCAG	0.609			NA											8	29	---	---	---	---	NA	NA	NA	NA	NA
MYT1L	23040	broad.mit.edu	37	2	1842936	1842936	+	Frame_Shift_Del	DEL	A	A	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:1842936delA	uc002qxe.2	-	21	3892	c.3065delT	c.(3064-3066)TTCfs	p.F1022fs	MYT1L_uc002qxd.2_Frame_Shift_Del_p.F1020fs|MYT1L_uc010ewk.2_Frame_Shift_Del_p.F18fs	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1022	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GTGTGTGAGGAAGCTGCCGCT	0.662			NA											22	16	---	---	---	---	NA	NA	NA	NA	NA
CAD	790	broad.mit.edu	37	2	27463992	27463993	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:27463992_27463993delAG	uc002rji.2	+	37	5867_5868	c.5705_5706delAG	c.(5704-5706)CAGfs	p.Q1902fs	CAD_uc010eyw.2_Frame_Shift_Del_p.Q1839fs	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1902	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCATCTCCCCAGAACCTGGGGA	0.604			NA											83	201	---	---	---	---	NA	NA	NA	NA	NA
CLASP1	23332	broad.mit.edu	37	2	122165204	122165204	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr2:122165204delG	uc002tnc.2	-	25	2902	c.2512delC	c.(2512-2514)CGCfs	p.R838fs	CLASP1_uc010yyv.1_5'UTR|CLASP1_uc002tmz.2_5'UTR|CLASP1_uc002tna.2_5'UTR|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Frame_Shift_Del_p.R818fs|CLASP1_uc010yza.1_Frame_Shift_Del_p.R810fs|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Frame_Shift_Del_p.R809fs	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	838					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					CCATATGAGCGCTCAGAGCAA	0.498			NA											21	83	---	---	---	---	NA	NA	NA	NA	NA
LRIG1	26018	broad.mit.edu	37	3	66465421	66465422	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr3:66465421_66465422insA	uc003dmx.2	-	5	583_584	c.569_570insT	c.(568-570)CTGfs	p.L190fs	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Frame_Shift_Ins_p.L190fs	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	190	Extracellular (Potential).|LRR 6.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GAAGAGTTAGCAGCGACCGTGA	0.495			NA											38	49	---	---	---	---	NA	NA	NA	NA	NA
TBC1D1	23216	broad.mit.edu	37	4	38091623	38091623	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr4:38091623delC	uc003gtb.2	+	13	2464	c.2121delC	c.(2119-2121)GGCfs	p.G707fs	TBC1D1_uc011byd.1_Frame_Shift_Del_p.G801fs|TBC1D1_uc010ifd.2_Frame_Shift_Del_p.G494fs|TBC1D1_uc011byf.1_Frame_Shift_Del_p.G578fs	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	707						nucleus	Rab GTPase activator activity			ovary(1)	1						GGCCCTTTGGCCCCCCACCAG	0.493			NA											66	119	---	---	---	---	NA	NA	NA	NA	NA
VPS52	6293	broad.mit.edu	37	6	33235055	33235056	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr6:33235055_33235056insA	uc003odm.1	-	11	1244_1245	c.1034_1035insT	c.(1033-1035)TTCfs	p.F345fs	VPS52_uc003odn.1_Intron	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	345					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TTCCTAGGGTGAAAATGGTGTT	0.564			NA											8	85	---	---	---	---	NA	NA	NA	NA	NA
WDR85	92715	broad.mit.edu	37	9	140459346	140459346	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chr9:140459346delT	uc004cnk.1	-	7	933	c.775delA	c.(775-777)AGCfs	p.S259fs	WDR85_uc004cnj.1_5'UTR|WDR85_uc004cnl.1_Frame_Shift_Del_p.S83fs|WDR85_uc004cnm.1_Frame_Shift_Del_p.S20fs|WDR85_uc004cnn.1_Intron|WDR85_uc010ncl.1_Frame_Shift_Del_p.S20fs	NM_138778	NP_620133	Q9BTV6	WDR85_HUMAN	WD repeat domain 85	259	WD 2.				peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)		GGGACTCACCTTCCCGTGGCC	0.642			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	X	153626818	153626821	+	Frame_Shift_Del	DEL	CTCT	CTCT	-			TCGA-75-5146-01A-01D-1625-08	TCGA-75-5146-10A-01D-1625-08	CTCT	CTCT	-	-	CTCT	CTCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	965a2bb7-6cd4-4309-beba-51ae74b8a980	47f4e18d-ab88-4abe-8dad-12268c017776	g.chrX:153626818_153626821delCTCT	uc010nuv.1	-	1	358_361	c.42_45delAGAG	c.(40-45)AGAGAGfs	p.R14fs	RPL10_uc004fkm.2_Intron|RPL10_uc004fko.2_Intron|RPL10_uc004fkn.1_5'UTR|RPL10_uc004fkp.1_5'Flank|RPL10_uc004fkq.1_5'Flank|RPL10_uc004fkr.1_5'Flank|SNORA70_uc010nux.1_5'Flank					Homo sapiens cDNA, FLJ97181.												NA						TCCGTTCCGACTCTCTCTTTTTCG	0.559			NA											147	123	---	---	---	---	NA	NA	NA	NA	NA
