Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6194814	6194814	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:6194814G>T	uc001amb.1	-	19	3076	c.2976C>A	c.(2974-2976)TGC>TGA	p.C992*	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	992					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGTGGTTGCAGCACTTTTTCA	0.572			NA											18	116					3.51602e-12	5.45318e-12	0.008871	1	0
KIAA0090	23065	broad.mit.edu	37	1	19566877	19566877	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:19566877C>T	uc001bbo.2	-	7	743	c.700G>A	c.(700-702)GTC>ATC	p.V234I	KIAA0090_uc001bbp.2_Missense_Mutation_p.V234I|KIAA0090_uc001bbq.2_Missense_Mutation_p.V234I|KIAA0090_uc001bbr.2_Missense_Mutation_p.V212I	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	234	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		CACACCAGGACAGCCTCATCC	0.552	GBM(4;72 124 25802 30195)		NA											15	22					0	0	0.004007	0	0
HSPG2	3339	broad.mit.edu	37	1	22149978	22149978	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:22149978C>T	uc001bfj.2	-	97	13047	c.13007G>A	c.(13006-13008)GGA>GAA	p.G4336E	LDLRAD2_uc001bfg.1_3'UTR|HSPG2_uc001bfi.2_Missense_Mutation_p.G353E|HSPG2_uc009vqd.2_Missense_Mutation_p.G4337E	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	4336	Laminin G-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GTCAGGGGCTCCGCCTGCCGG	0.697			NA											2	2					0	0	0.009096	0	0
LCK	3932	broad.mit.edu	37	1	32741606	32741606	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:32741606C>G	uc001bux.2	+	7	711	c.573C>G	c.(571-573)TTC>TTG	p.F191L	LCK_uc001buy.2_Missense_Mutation_p.F191L|LCK_uc001buz.2_Missense_Mutation_p.F191L|LCK_uc010ohc.1_Missense_Mutation_p.F235L|LCK_uc001bva.2_Missense_Mutation_p.F249L	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	191	SH2.|Interaction with PTPRH.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	ACGGTGGCTTCTACATCTCCC	0.552			NA	T	TRB@	T-ALL								29	24					0	0	0.009535	0	0
CSMD2	114784	broad.mit.edu	37	1	34631410	34631410	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:34631410C>T	uc001bxn.1	-	1	34	c.5G>A	c.(4-6)AGG>AAG	p.R2K	CSMD2_uc001bxm.1_5'Flank|C1orf94_uc001bxs.3_5'Flank	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTTATGAGCCTCATTCACAA	0.572			NA											17	23					0	0	0.007413	0	0
EIF2C3	192669	broad.mit.edu	37	1	36501854	36501854	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:36501854C>A	uc001bzp.2	+	14	2084	c.1828C>A	c.(1828-1830)CCT>ACT	p.P610T	EIF2C3_uc001bzq.2_Missense_Mutation_p.P376T	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	610	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGGAAAGAAGCCTTCTATTGC	0.378	Colon(144;60 2363 31043 40539)		NA											16	67					3.99206e-14	6.45891e-14	0.007413	1	0
GRIK3	2899	broad.mit.edu	37	1	37271752	37271752	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:37271752A>G	uc001caz.2	-	14	2402	c.2267T>C	c.(2266-2268)ATC>ACC	p.I756T	GRIK3_uc001cba.1_Missense_Mutation_p.I756T	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	756	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GAGGCCCCCGATCTGGGTGAG	0.662			NA											16	29					0	0	0.006122	0	0
SNIP1	79753	broad.mit.edu	37	1	38006344	38006344	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:38006344G>A	uc001cbi.2	-	3	413	c.340C>T	c.(340-342)CAT>TAT	p.H114Y	SNIP1_uc010oid.1_Intron	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	114	Arg-rich.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				CTCCGGGGATGATCCTCACGC	0.463			NA											7	51					0	0	0.00308	0	0
CYP4A11	1579	broad.mit.edu	37	1	47398461	47398461	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:47398461C>T	uc001cqp.3	-	11	1387	c.1336G>A	c.(1336-1338)GCT>ACT	p.A446T	CYP4A11_uc001cqq.2_Missense_Mutation_p.A446T	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	446					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GGCAGGAAAGCGTGGCTGTGT	0.517			NA											57	282					0	0	0.01441	0	0
CACHD1	57685	broad.mit.edu	37	1	65157011	65157011	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:65157011A>T	uc001dbo.1	+	27	3544	c.3439A>T	c.(3439-3441)AGC>TGC	p.S1147C	CACHD1_uc001dbp.1_Missense_Mutation_p.S902C|CACHD1_uc001dbq.1_Missense_Mutation_p.S902C|CACHD1_uc010opa.1_Missense_Mutation_p.S391C	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1198	Cytoplasmic (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						TCTAGGTTACAGCACCATGAG	0.483			NA											18	45					0	0	0.007413	0	0
ELTD1	64123	broad.mit.edu	37	1	79383572	79383572	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:79383572G>T	uc001diq.3	-	11	1781	c.1625C>A	c.(1624-1626)GCC>GAC	p.A542D		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	542	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AACTACCACGGCTGGGCTTAG	0.373			NA											21	129					7.87624e-14	1.26175e-13	0.00278	1	0
LPHN2	23266	broad.mit.edu	37	1	82416126	82416126	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:82416126G>A	uc001dit.3	+	7	1633	c.1452G>A	c.(1450-1452)AGG>AGA	p.R484R	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.R484R|LPHN2_uc001div.2_Silent_p.R484R|LPHN2_uc009wcd.2_Silent_p.R484R|LPHN2_uc001diw.2_Silent_p.R55R	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	484	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AGACACAAAGGGGAATGATGG	0.393			NA											7	50					0	0	0.00308	0	0
C1orf52	148423	broad.mit.edu	37	1	85724262	85724262	+	Silent	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:85724262T>C	uc001dkv.2	-	2	459	c.420A>G	c.(418-420)CCA>CCG	p.P140P	C1orf52_uc001dkw.2_RNA|C1orf52_uc001dkx.3_RNA|C1orf52_uc009wcn.2_Silent_p.P140P	NM_198077	NP_932343	Q8N6N3	CA052_HUMAN	hypothetical protein LOC148423	140										ovary(1)	1				all cancers(265;0.0105)|Epithelial(280;0.0293)		TAGCATTCTGTGGAGCATCAT	0.478			NA											73	140					0	0	0.01441	0	0
CLCA1	1179	broad.mit.edu	37	1	86954799	86954799	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:86954799G>A	uc001dlt.2	+	8	1432	c.1303G>A	c.(1303-1305)GTC>ATC	p.V435I	CLCA1_uc001dls.1_Missense_Mutation_p.V374I	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	435	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CATCCACACAGTCGCTTTGGG	0.463			NA											8	34					0	0	0.00308	0	0
BCAS2	10286	broad.mit.edu	37	1	115124154	115124154	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:115124154T>C	uc001efa.2	-	1	112	c.59A>G	c.(58-60)GAT>GGT	p.D20G	DENND2C_uc001eez.2_Intron	NM_005872	NP_005863	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	20					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			large_intestine(1)	1	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAACCTTGATCAAAATACGG	0.547			NA											8	19					0	0	0.006214	0	0
DENND2C	163259	broad.mit.edu	37	1	115168229	115168229	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:115168229C>A	uc001efd.1	-	4	1079	c.377G>T	c.(376-378)AGC>ATC	p.S126I	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.S126I	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	126										skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTTTACAGCTTTCAATTTC	0.363			NA											11	85					6.40141e-05	7.65967e-05	0.010729	1	0
FLG	2312	broad.mit.edu	37	1	152275876	152275876	+	Missense_Mutation	SNP	C	C	T	rs145079750		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:152275876C>T	uc001ezu.1	-	3	11522	c.11486G>A	c.(11485-11487)CGT>CAT	p.R3829H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3829	Filaggrin 23.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCATGGTGACGCGACCCTGA	0.587			NA							Ichthyosis				28	321					0	0	0.004878	0	0
FLG	2312	broad.mit.edu	37	1	152275883	152275883	+	Missense_Mutation	SNP	C	C	A	rs140464988		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:152275883C>A	uc001ezu.1	-	3	11515	c.11479G>T	c.(11479-11481)GGG>TGG	p.G3827W		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3827	Filaggrin 23.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACGCGACCCTGAGTGCCTG	0.597			NA							Ichthyosis				33	337					3.61848e-18	6.29357e-18	0.007835	1	0
FLG	2312	broad.mit.edu	37	1	152282768	152282769	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:152282768_152282769GG>TT	uc001ezu.1	-	3	4629_4630	c.4593_4594CC>AA	c.(4591-4596)TCCCAT>TCAAAT	p.H1532N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1532	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTGCCCATGGGAGGCATCAG	0.559			NA							Ichthyosis				120	356					0	0	0.004672	0	0
LCE2C	353140	broad.mit.edu	37	1	152648564	152648564	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:152648564C>A	uc001fah.2	+	2	128	c.73C>A	c.(73-75)CCA>ACA	p.P25T		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	25	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			cccaaaatgtccacctaagtg	0.418			NA											43	73					2.35958e-20	4.2247e-20	0.009718	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156955931	156955931	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:156955931G>A	uc001fqo.2	-	2	1107	c.67C>T	c.(67-69)CCA>TCA	p.P23S	ARHGEF11_uc001fqn.2_Missense_Mutation_p.P23S	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	23					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTGCGCTCTGGTGCAGAATCT	0.488			NA											36	64					0	0	0.00623	0	0
CD5L	922	broad.mit.edu	37	1	157805822	157805822	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:157805822A>G	uc001frk.3	-	3	322	c.179T>C	c.(178-180)GTG>GCG	p.V60A		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	60	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCGGCACAACACAGCCACGTC	0.592			NA											24	160					0	0	0.00278	0	0
OR10R2	343406	broad.mit.edu	37	1	158450371	158450371	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:158450371G>T	uc010pik.1	+	1	704	c.704G>T	c.(703-705)TGT>TTT	p.C235F	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	235	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					CTGTTTATCTGTGTTTCTTAT	0.443			NA											50	65					6.08268e-21	1.09309e-20	0.01441	1	0
CRP	1401	broad.mit.edu	37	1	159683541	159683541	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:159683541C>A	uc001ftw.2	-	2	553	c.449G>T	c.(448-450)AGC>ATC	p.S150I	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	150	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CAAGATGATGCTTGCTTCTGC	0.552			NA											80	293					3.05217e-42	5.82905e-42	0.01441	1	0
TNR	7143	broad.mit.edu	37	1	175365799	175365799	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:175365799G>A	uc001gkp.1	-	3	1202	c.1121C>T	c.(1120-1122)CCT>CTT	p.P374L	TNR_uc009wwu.1_Missense_Mutation_p.P374L|TNR_uc010pmz.1_Silent_p.A339A	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	374	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CCAATCTCCAGGCACCCGCTG	0.592			NA											18	45					0	0	0.00499	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564173	176564173	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:176564173T>A	uc001gkz.2	+	3	2597	c.1433T>A	c.(1432-1434)CTT>CAT	p.L478H	PAPPA2_uc001gky.1_Missense_Mutation_p.L478H|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	478	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TACCCACGACTTGAGGTTCTC	0.537			NA											30	57					0	0	0.009535	0	0
CACNA1E	777	broad.mit.edu	37	1	181725204	181725204	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:181725204G>A	uc001gow.2	+	29	4267	c.4102G>A	c.(4102-4104)GTC>ATC	p.V1368I	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1256I|CACNA1E_uc001gox.1_Missense_Mutation_p.V594I|CACNA1E_uc009wxt.2_Missense_Mutation_p.V594I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1368	Extracellular (Potential).|III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCTCTTCACCGTCTCCACAGG	0.517			NA											8	25					0	0	0.004482	0	0
C1orf26	54823	broad.mit.edu	37	1	185191096	185191096	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:185191096T>C	uc001grg.3	+	15	2351	c.2237T>C	c.(2236-2238)CTT>CCT	p.L746P	C1orf26_uc001grh.3_Missense_Mutation_p.L746P	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	746											0						AGTTCTCATCTTCCCCAACCC	0.363			NA											32	241					0	0	0.012213	0	0
HMCN1	83872	broad.mit.edu	37	1	186158963	186158963	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:186158963C>A	uc001grq.1	+	107	17090	c.16861C>A	c.(16861-16863)CAG>AAG	p.Q5621K	HMCN1_uc001grs.1_Missense_Mutation_p.Q1073K	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5621					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CATTGAATATCAGACCACATT	0.453			NA											13	97					0.00010058	0.000118315	0.013537	1	0
RGS1	5996	broad.mit.edu	37	1	192545461	192545461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:192545461G>T	uc001gsi.1	+	2	250	c.184G>T	c.(184-186)GAA>TAA	p.E62*	RGS1_uc010pou.1_Nonsense_Mutation_p.E62*	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	62					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				CCCACATCTGGAATCTGGAAT	0.318			NA											27	57					3.1745e-13	5.00317e-13	0.008361	1	0
RGS1	5996	broad.mit.edu	37	1	192547461	192547461	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:192547461C>A	uc001gsi.1	+	4	456	c.390C>A	c.(388-390)CCC>CCA	p.P130P	RGS1_uc010pou.1_Silent_p.P130P	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	130	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				ATCTTTTGCCCTGTAAAGCAG	0.368			NA											70	139					7.46257e-40	1.41964e-39	0.01441	1	0
DENND1B	163486	broad.mit.edu	37	1	197621405	197621405	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:197621405T>A	uc001guf.3	-	7	745	c.407A>T	c.(406-408)CAC>CTC	p.H136L	DENND1B_uc010ppe.1_Missense_Mutation_p.H136L|DENND1B_uc010ppf.1_RNA|DENND1B_uc001gue.3_Missense_Mutation_p.H126L|DENND1B_uc001gug.3_5'UTR	NM_144977	NP_659414	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 2	136	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						TGGTACTGGGTGGTTATACAG	0.323			NA											11	47					0	0	0.010729	0	0
LGR6	59352	broad.mit.edu	37	1	202245537	202245537	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:202245537C>A	uc001gxu.2	+	5	532	c.532C>A	c.(532-534)CCT>ACT	p.P178T	LGR6_uc001gxv.2_Missense_Mutation_p.P126T|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Intron|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	178	LRR 4.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						CACGGAGATCCCTGTCAGGGC	0.627			NA											15	26					1.3612e-06	1.78681e-06	0.003163	1	0
USH2A	7399	broad.mit.edu	37	1	216369927	216369927	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:216369927G>T	uc001hku.1	-	19	4606	c.4219C>A	c.(4219-4221)CCT>ACT	p.P1407T	USH2A_uc001hkv.2_Missense_Mutation_p.P1407T	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1407	Extracellular (Potential).|Fibronectin type-III 4.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACTGTTGAGGTGATTGTTCA	0.388			NA								HNSCC(13;0.011)			32	89					1.45844e-13	2.32871e-13	0.013726	1	0
OBSCN	84033	broad.mit.edu	37	1	228412410	228412410	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:228412410G>T	uc009xez.1	+	9	2948	c.2904G>T	c.(2902-2904)CGG>CGT	p.R968R	OBSCN_uc001hsn.2_Silent_p.R968R	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	968	Ig-like 9.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGGGCCAGCGGCTCTCCTTCC	0.612			NA											10	23					7.48243e-07	9.87518e-07	0.006214	1	0
HEATR1	55127	broad.mit.edu	37	1	236746130	236746130	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:236746130C>A	uc001hyd.1	-	19	2593	c.2468G>T	c.(2467-2469)AGG>ATG	p.R823M	HEATR1_uc009xgh.1_Missense_Mutation_p.R66M	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	823					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CAGATAGTCCCTGCTGTCTTC	0.423			NA											20	42					1.40151e-16	2.36171e-16	0.010504	1	0
GREM2	64388	broad.mit.edu	37	1	240656615	240656615	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:240656615G>T	uc001hys.2	-	2	441	c.161C>A	c.(160-162)GCC>GAC	p.A54D		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	54					BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CTGGCTGGAGGCCAGCACCTC	0.667			NA											7	33					1.06961e-07	1.45911e-07	0.00308	1	0
ZNF238	10472	broad.mit.edu	37	1	244218618	244218618	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:244218618G>A	uc001iae.2	+	1	2037	c.1515G>A	c.(1513-1515)TTG>TTA	p.L505L	ZNF238_uc001iad.3_Silent_p.L514L|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	505					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			CACTGAGCTTGCCTACTGTCA	0.383			NA											21	87					0	0	0.003954	0	0
ZNF124	7678	broad.mit.edu	37	1	247319988	247319988	+	Silent	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:247319988A>G	uc001ick.2	-	4	1075	c.936T>C	c.(934-936)CAT>CAC	p.H312H	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Silent_p.H250H	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	312	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			TCTCTCCAGTATGAGTCCTTT	0.413			NA											37	80					0	0	0.00874	0	0
VN1R5	317705	broad.mit.edu	37	1	247419801	247419801	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:247419801A>G	uc010pyu.1	+	2	428	c.428A>G	c.(427-429)CAG>CGG	p.Q143R		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	143	Helical; Name=4; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			AGTGTGCTCCAGGCCATCATC	0.483	GBM(98;63 1399 4825 21305 33017)		NA											17	109					0	0	0.006122	0	0
OR2B11	127623	broad.mit.edu	37	1	247614347	247614347	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:247614347C>A	uc010pyx.1	-	1	938	c.938G>T	c.(937-939)TGG>TTG	p.W313L		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ACAGAGCCTCCAGATCCTGGC	0.458			NA											96	298					4.04957e-52	7.76434e-52	0.01441	1	0
OR1C1	26188	broad.mit.edu	37	1	247921653	247921653	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:247921653C>A	uc010pza.1	-	1	56	c.56G>T	c.(55-57)AGC>ATC	p.S19I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CTCTGCTGAGCTAGGAAGTCC	0.423			NA											7	19					2.0095e-06	2.59582e-06	0.001984	1	0
OR2T2	401992	broad.mit.edu	37	1	248616419	248616419	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr1:248616419C>A	uc001iek.1	+	1	321	c.321C>A	c.(319-321)ACC>ACA	p.T107T		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTACCTGACCCTGATTGGAG	0.547			NA											31	162					1.99505e-19	3.54595e-19	0.012213	1	0
C10orf18	54906	broad.mit.edu	37	10	5781857	5781857	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:5781857C>A	uc001iij.2	+	13	2349	c.1724C>A	c.(1723-1725)TCT>TAT	p.S575Y	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	575										ovary(1)|central_nervous_system(1)	2						AAAGAAAATTCTTTGCGAGGT	0.378			NA											16	118					5.03518e-11	7.59175e-11	0.007413	1	0
USP6NL	9712	broad.mit.edu	37	10	11505455	11505455	+	Nonsense_Mutation	SNP	G	G	T	rs35440878		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:11505455G>T	uc001ikt.3	-	15	1793	c.1472C>A	c.(1471-1473)TCA>TAA	p.S491*	USP6NL_uc001iks.1_Nonsense_Mutation_p.S508*	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	491						intracellular	Rab GTPase activator activity				0						TGAGACGTCTGACGGTTTATT	0.527			NA											23	143					1.55469e-16	2.61081e-16	0.00333	1	0
CUBN	8029	broad.mit.edu	37	10	16955844	16955844	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:16955844G>T	uc001ioo.2	-	48	7551	c.7499C>A	c.(7498-7500)GCC>GAC	p.A2500D		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2500	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CGGATGCGTGGCCAGCCTCAG	0.502			NA											28	66					9.65021e-13	1.5063e-12	0.010818	1	0
C10orf68	79741	broad.mit.edu	37	10	33135305	33135305	+	Missense_Mutation	SNP	G	G	T	rs144109242		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:33135305G>T	uc001iwn.3	+	17	1808	c.1335G>T	c.(1333-1335)GAG>GAT	p.E445D	C10orf68_uc001iwl.1_Missense_Mutation_p.E404D|C10orf68_uc001iwm.1_Missense_Mutation_p.E449D|C10orf68_uc010qei.1_Missense_Mutation_p.E421D|C10orf68_uc001iwo.3_RNA	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	445										skin(2)|ovary(1)	3						ATTCTATAGAGACTGATAAAG	0.284			NA											7	45					8.12818e-05	9.60783e-05	0.001984	1	0
ITGB1	3688	broad.mit.edu	37	10	33209284	33209284	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:33209284G>A	uc001iws.3	-	10	1294	c.1158C>T	c.(1156-1158)AAC>AAT	p.N386N	ITGB1_uc001iwp.3_Silent_p.N386N|ITGB1_uc001iwq.3_Silent_p.N386N|ITGB1_uc001iwr.3_Silent_p.N386N|ITGB1_uc001iwt.3_Silent_p.N386N|ITGB1_uc001iwu.1_Silent_p.N386N	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	386	Extracellular (Potential).			EN -> DG (in Ref. 6; AAI13902).	axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ACAATTTGCCGTTTTCCAAAA	0.363			NA											17	45					0	0	0.004007	0	0
GDF2	2658	broad.mit.edu	37	10	48414122	48414122	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:48414122C>G	uc001jfa.1	-	2	909	c.746G>C	c.(745-747)AGA>ACA	p.R249T		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	249					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GGGCAGGTTTCTGGAACCTGG	0.557			NA											5	27					0	0	0.000602	0	0
GDF2	2658	broad.mit.edu	37	10	48416440	48416440	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:48416440G>A	uc001jfa.1	-	1	417	c.254C>T	c.(253-255)CCG>CTG	p.P85L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	85					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GTACTGCGGCGGCTCCACCCT	0.542			NA											6	42					0	0	0.00308	0	0
JMJD1C	221037	broad.mit.edu	37	10	64968213	64968213	+	Silent	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:64968213G>C	uc001jmn.2	-	10	3516	c.3216C>G	c.(3214-3216)CGC>CGG	p.R1072R	JMJD1C_uc001jml.2_Silent_p.R853R|JMJD1C_uc001jmm.2_Silent_p.R784R|JMJD1C_uc010qiq.1_Silent_p.R890R|JMJD1C_uc009xpi.2_Silent_p.R890R|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Silent_p.R109R	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1072					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CTGATACTGAGCGTTCTACAT	0.398			NA											29	196					0	0	0.007291	0	0
ECD	11319	broad.mit.edu	37	10	74899485	74899485	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:74899485T>A	uc001jtn.2	-	10	1381	c.1138A>T	c.(1138-1140)ATG>TTG	p.M380L	ECD_uc009xqx.2_Missense_Mutation_p.M413L|ECD_uc009xqy.2_Missense_Mutation_p.M337L|ECD_uc001jto.2_Missense_Mutation_p.M79L	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	380					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					CCAGGGCTCATAGCAAGAGAA	0.323			NA											75	167					0	0	0.01441	0	0
TTC18	118491	broad.mit.edu	37	10	75029452	75029452	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:75029452C>A	uc009xrc.2	-	26	3278	c.3157G>T	c.(3157-3159)GAG>TAG	p.E1053*	TTC18_uc001jty.2_Nonsense_Mutation_p.E1053*|TTC18_uc001jtv.3_Nonsense_Mutation_p.E157*|TTC18_uc001jtw.3_Nonsense_Mutation_p.E127*|TTC18_uc001jtx.2_Nonsense_Mutation_p.E404*	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	1053	TPR 7.						binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					AGAGCATCCTCAGCCTCTGTG	0.423			NA											6	36					0.00198382	0.0022108	0.001984	1	0
GHITM	27069	broad.mit.edu	37	10	85904649	85904649	+	Silent	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:85904649C>G	uc001kcs.1	+	5	564	c.360C>G	c.(358-360)GTC>GTG	p.V120V	GHITM_uc010qma.1_Intron|GHITM_uc010qmb.1_Silent_p.V50V	NM_014394	NP_055209	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	120	Mitochondrial intermembrane (Potential).				apoptosis	integral to membrane|mitochondrial inner membrane					0						CTCAGTATGTCAAGGATAGAA	0.294			NA											9	86					0	0	0.006214	0	0
GRID1	2894	broad.mit.edu	37	10	87407154	87407155	+	Splice_Site	DNP	CC	CC	AA			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:87407154_87407155CC>AA	uc001kdl.1	-	13	2099	c.1998_splice	c.e13-1	p.R666_splice	GRID1_uc009xsu.1_Splice_Site|GRID1_uc010qmf.1_Splice_Site_p.R237_splice|uc001kdm.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1							cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CCTGGAAAGTCCTGAAATGCAG	0.53			NA								Multiple Myeloma(13;0.14)			20	105					0	0	0.004672	0	0
BTAF1	9044	broad.mit.edu	37	10	93788545	93788545	+	Splice_Site	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:93788545A>T	uc001khr.2	+	38	5505	c.5407_splice	c.e38-2	p.D1803_splice		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ATTTTTCTTAAGGATGGCAAA	0.308			NA											4	42					0	0	0.009096	0	0
TLL2	7093	broad.mit.edu	37	10	98192670	98192671	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:98192670_98192671GG>AT	uc001kml.1	-	4	639_640	c.413_414CC>AT	c.(412-414)GCC>GAT	p.A138D	TLL2_uc009xvf.1_Intron	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	138					cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TCTTGGCTGCGGCATGCAAGGT	0.55			NA											13	44					0	0	0.004672	0	0
HPSE2	60495	broad.mit.edu	37	10	100995342	100995342	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:100995342G>C	uc001kpn.1	-	1	278	c.218C>G	c.(217-219)ACA>AGA	p.T73R	HPSE2_uc009xwc.1_Missense_Mutation_p.T63R|HPSE2_uc001kpo.1_Missense_Mutation_p.T63R|HPSE2_uc009xwd.1_Missense_Mutation_p.T63R	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	73					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		CTCATTGACTGTCCTGACTGG	0.502			NA											16	112					0	0	0.003163	0	0
TRIM8	81603	broad.mit.edu	37	10	104404673	104404673	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:104404673C>T	uc001kvz.2	+	1	422	c.299C>T	c.(298-300)CCG>CTG	p.P100L		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	100	B box-type 1.					cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CGCGGCCCCCCGCTGCCCGCG	0.701			NA											4	5					0	0	0.009096	0	0
TDRD1	56165	broad.mit.edu	37	10	115971637	115971637	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:115971637G>A	uc001lbg.1	+	14	1826	c.1673G>A	c.(1672-1674)TGG>TAG	p.W558*	TDRD1_uc001lbf.2_Intron|TDRD1_uc001lbh.1_Nonsense_Mutation_p.W549*|TDRD1_uc001lbi.1_Nonsense_Mutation_p.W549*|TDRD1_uc010qsc.1_Intron|TDRD1_uc001lbj.2_Nonsense_Mutation_p.W267*	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	558	Tudor 2.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GATGATCAGTGGTACCGTGCC	0.378			NA											16	114					0	0	0.010504	0	0
FAM160B1	57700	broad.mit.edu	37	10	116608455	116608455	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:116608455G>T	uc001lcb.2	+	13	2097	c.1762G>T	c.(1762-1764)GGC>TGC	p.G588C	FAM160B1_uc001lcc.2_Missense_Mutation_p.G588C	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	588										lung(1)	1						CCATGTTGAGGGCACAGGATA	0.428			NA											4	26					0.00024832	0.000285217	0.009096	1	0
MKI67	4288	broad.mit.edu	37	10	129906387	129906387	+	Silent	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr10:129906387T>C	uc001lke.2	-	13	3912	c.3717A>G	c.(3715-3717)GAA>GAG	p.E1239E	MKI67_uc001lkf.2_Silent_p.E879E|MKI67_uc009yav.1_Silent_p.E814E|MKI67_uc009yaw.1_Silent_p.E389E	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1239	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAGCCACTAATTCCTCGGTGT	0.512			NA											19	53					0	0	0.008871	0	0
NLRP6	171389	broad.mit.edu	37	11	284494	284494	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:284494C>T	uc010qvs.1	+	7	2392	c.2392C>T	c.(2392-2394)CAG>TAG	p.Q798*	NLRP6_uc010qvt.1_Nonsense_Mutation_p.Q797*	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	798						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCCTGACCCCCAGCGAGGGCT	0.697			NA											12	14					0	0	0.013537	0	0
OR56A1	120796	broad.mit.edu	37	11	6048493	6048493	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:6048493C>T	uc010qzw.1	-	1	442	c.442G>A	c.(442-444)GTG>ATG	p.V148M		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTTTGGCCACAAATTGATTA	0.507			NA											6	42					0	0	0.001984	0	0
FAM160A2	84067	broad.mit.edu	37	11	6236055	6236055	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:6236055C>A	uc001mcl.3	-	10	2661	c.2302G>T	c.(2302-2304)GCC>TCC	p.A768S	FAM160A2_uc001mck.3_Missense_Mutation_p.A782S	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	768					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						GCCAGCTGGGCCACCAGCCCC	0.612			NA											5	18					3.59834e-05	4.39195e-05	0.001168	1	0
NELL1	4745	broad.mit.edu	37	11	21555957	21555957	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:21555957C>G	uc001mqe.2	+	16	1836	c.1683C>G	c.(1681-1683)CAC>CAG	p.H561Q	NELL1_uc001mqf.2_Intron|NELL1_uc009yid.2_Missense_Mutation_p.H589Q|NELL1_uc010rdo.1_Missense_Mutation_p.H504Q|NELL1_uc010rdp.1_Intron|NELL1_uc001mqh.2_Missense_Mutation_p.T171R	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	561	EGF-like 5; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TTGAGTGCCACAACCATTCCC	0.483			NA											25	43					0	0	0.005443	0	0
API5	8539	broad.mit.edu	37	11	43364037	43364037	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:43364037C>T	uc010rfh.1	+	14	1725	c.1552C>T	c.(1552-1554)CGT>TGT	p.R518C	API5_uc010rfg.1_Missense_Mutation_p.R507C|API5_uc001mxf.2_3'UTR|API5_uc010rfi.1_3'UTR	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	Error:Variant_position_missing_in_Q9BZZ5_after_alignment					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						ACGAGGAAATCGTAGTCGGGG	0.463	Pancreas(1;98 122 5625 20895 49453)		NA											7	38					0	0	0.00308	0	0
AGBL2	79841	broad.mit.edu	37	11	47726214	47726214	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:47726214A>T	uc001ngg.2	-	6	567	c.467T>A	c.(466-468)GTA>GAA	p.V156E	AGBL2_uc010rhq.1_Missense_Mutation_p.V118E|AGBL2_uc001ngh.1_Missense_Mutation_p.V100E	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	156					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						ACGTGGGTTTACTTCATCCAA	0.448			NA											17	78					0	0	0.006122	0	0
OR4A47	403253	broad.mit.edu	37	11	48511031	48511031	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:48511031A>T	uc010rhx.1	+	1	687	c.687A>T	c.(685-687)AAA>AAT	p.K229N		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTAGTCAGAAAGGGAGGCAAA	0.443			NA											43	94					0	0	0.007835	0	0
OR8J1	219477	broad.mit.edu	37	11	56128008	56128008	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:56128008G>T	uc010rjh.1	+	1	286	c.286G>T	c.(286-288)GAA>TAA	p.E96*		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E96A(1)		ovary(2)	2	Esophageal squamous(21;0.00448)					CTCATTCTATGAATGTGCCAC	0.418			NA											13	115					0.00244969	0.00272375	0.00245	1	0
OR9I1	219954	broad.mit.edu	37	11	57886684	57886684	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:57886684G>T	uc001nml.1	-	1	233	c.233C>A	c.(232-234)ACC>AAC	p.T78N	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	78	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				GATCTGAGGGGTGATGACTGA	0.498			NA											23	17					6.44725e-10	9.42886e-10	0.014323	1	0
MS4A14	84689	broad.mit.edu	37	11	60184263	60184263	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:60184263G>C	uc001npj.2	+	5	2387	c.1822G>C	c.(1822-1824)GAC>CAC	p.D608H	MS4A14_uc001npi.2_Missense_Mutation_p.D496H|MS4A14_uc001npn.2_Missense_Mutation_p.D346H|MS4A14_uc001npk.2_Missense_Mutation_p.D591H|MS4A14_uc001npl.2_Missense_Mutation_p.D346H|MS4A14_uc001npm.2_Missense_Mutation_p.D346H	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	608	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						GCAAACTGAAGACCAGCCGGC	0.453			NA											4	20					0	0	0.009096	0	0
MOGAT2	80168	broad.mit.edu	37	11	75438534	75438535	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:75438534_75438535CC>AA	uc010rru.1	+	3	325_326	c.325_326CC>AA	c.(325-327)CCC>AAC	p.P109N	MOGAT2_uc001oww.1_Missense_Mutation_p.P109N|MOGAT2_uc010rrv.1_Missense_Mutation_p.P27N	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	109	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					GGGCTTCCACCCCCATGGAGTC	0.53			NA											41	21					0	0	0.004672	0	0
FAT3	120114	broad.mit.edu	37	11	92495099	92495099	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:92495099C>A	uc001pdj.3	+	4	3764	c.3747C>A	c.(3745-3747)GAC>GAA	p.D1249E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1249	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGAAAATGACAACAAGCCCC	0.463			NA								TCGA Ovarian(4;0.039)			15	186					6.31663e-08	8.66534e-08	0.003163	1	0
HEPHL1	341208	broad.mit.edu	37	11	93837765	93837765	+	Silent	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:93837765A>G	uc001pep.2	+	16	2911	c.2754A>G	c.(2752-2754)AGA>AGG	p.R918R	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	918	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGGGAAGAAGAAGTGACGTTG	0.348			NA											10	86					0	0	0.006214	0	0
HEPHL1	341208	broad.mit.edu	37	11	93839281	93839281	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:93839281G>T	uc001pep.2	+	17	3187	c.3030G>T	c.(3028-3030)GAG>GAT	p.E1010D	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	1010	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATCATGCTGAGAGCTTTCTTT	0.358			NA											50	47					2.23044e-30	4.21017e-30	0.01441	1	0
APOA4	337	broad.mit.edu	37	11	116692349	116692349	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:116692349A>T	uc001pps.1	-	3	529	c.425T>A	c.(424-426)CTG>CAG	p.L142Q		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CTGGGTGCGCAGCTGGTCCGC	0.398			NA											15	6					0	0	0.003163	0	0
IFT46	56912	broad.mit.edu	37	11	118425705	118425705	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:118425705C>G	uc001ptp.1	-	6	732	c.354G>C	c.(352-354)AAG>AAC	p.K118N	IFT46_uc001pto.1_Missense_Mutation_p.K169N|IFT46_uc009zaf.1_Missense_Mutation_p.K169N	NM_020153	NP_064538	Q9NQC8	IFT46_HUMAN	IFT46	118					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding				0						CTGACTATACCTTTAAGAATG	0.418			NA											25	74					0	0	0.00333	0	0
PVRL1	5818	broad.mit.edu	37	11	119508809	119508809	+	Nonstop_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:119508809T>C	uc001pwu.1	-	8	1548	c.1376A>G	c.(1375-1377)TAG>TGG	p.*459W		NM_203285	NP_976030	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 2	459	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GGTCCTGGGCTAGGGGCACTC	0.642			NA											7	14					0	0	0.001984	0	0
OR10S1	219873	broad.mit.edu	37	11	123847594	123847594	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:123847594G>A	uc001pzm.1	-	1	805	c.805C>T	c.(805-807)CCT>TCT	p.P269S		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	269	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		ATACAGACAGGTGGCACGTAG	0.612			NA											9	75					0	0	0.004482	0	0
ROBO4	54538	broad.mit.edu	37	11	124756396	124756396	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:124756396C>T	uc001qbg.2	-	16	2898	c.2758G>A	c.(2758-2760)GGT>AGT	p.G920S	ROBO4_uc010sas.1_Missense_Mutation_p.G775S|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Missense_Mutation_p.G478S	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	920					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGCTCTAGACCGAAACCAAAG	0.567			NA											31	18					0	0	0.008361	0	0
OPCML	4978	broad.mit.edu	37	11	132290114	132290114	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:132290114G>T	uc001qgs.2	-	7	1061	c.1011C>A	c.(1009-1011)CTC>CTA	p.L337L	OPCML_uc001qgu.2_Silent_p.L330L|OPCML_uc010sck.1_Silent_p.L346L|OPCML_uc001qgt.2_Silent_p.L336L|OPCML_uc010scl.1_Silent_p.L296L	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	337					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		AGTGGGCTAAGAGGGTCCCTG	0.512			NA											28	24					6.00712e-18	1.03373e-17	0.012213	1	0
TULP3	7289	broad.mit.edu	37	12	3040343	3040343	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:3040343G>T	uc010seh.1	+	6	714	c.633G>T	c.(631-633)AGG>AGT	p.R211S	TULP3_uc010sef.1_RNA|TULP3_uc009zec.1_5'UTR|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.R211S|TULP3_uc010sei.1_Missense_Mutation_p.R68S	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	211					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGGATAAAAGGGGAATGGATC	0.443			NA											17	79					1.33834e-09	1.92263e-09	0.007413	1	0
ANO2	57101	broad.mit.edu	37	12	5672645	5672645	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:5672645G>T	uc001qnm.2	-	26	2889	c.2817C>A	c.(2815-2817)AGC>AGA	p.S939R		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	944	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CCACTAATAAGCTCTTCTCTT	0.532			NA											11	32					6.40141e-05	7.65967e-05	0.010729	1	0
VWF	7450	broad.mit.edu	37	12	6182795	6182795	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:6182795G>T	uc001qnn.1	-	8	1237	c.987C>A	c.(985-987)TGC>TGA	p.C329*	VWF_uc010set.1_Nonsense_Mutation_p.C329*	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	329	TIL 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CAGGGCAGCTGCAGCCATCCA	0.532			NA											9	53					1.12685e-05	1.39994e-05	0.004482	1	0
A2M	2	broad.mit.edu	37	12	9243991	9243991	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:9243991G>T	uc001qvk.1	-	19	2388	c.2275C>A	c.(2275-2277)CCT>ACT	p.P759T	A2M_uc009zgk.1_Missense_Mutation_p.P609T	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	759					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGGTGTCAGGGACTGTTACT	0.517			NA											4	76					1.23904e-05	1.5354e-05	0.000602	1	0
PZP	5858	broad.mit.edu	37	12	9317929	9317929	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:9317929G>T	uc001qvl.2	-	19	2322	c.2293C>A	c.(2293-2295)CCT>ACT	p.P765T	PZP_uc009zgl.2_Missense_Mutation_p.P634T|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Missense_Mutation_p.P97T	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						ATGGTGTCAGGGACTGTTACT	0.527	Melanoma(125;1402 1695 4685 34487 38571)		NA											12	42					9.31168e-06	1.16277e-05	0.001855	1	0
CLEC1B	51266	broad.mit.edu	37	12	10150960	10150960	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:10150960G>A	uc001qwu.2	-	2	284	c.84C>T	c.(82-84)TCC>TCT	p.S28S	CLEC1B_uc009zhd.2_Intron	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	28	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						CACGCCACCAGGAGGAGGATG	0.557			NA											22	36					0	0	0.012319	0	0
KIAA1467	57613	broad.mit.edu	37	12	13215867	13215867	+	Silent	SNP	C	C	T	rs146598933	byFrequency	TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:13215867C>T	uc001rbi.2	+	5	833	c.810C>T	c.(808-810)GAC>GAT	p.D270D	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	270						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TGGATGAAGACGGTGTTCGAG	0.448			NA											42	242					0	0	0.01441	0	0
RERGL	79785	broad.mit.edu	37	12	18234173	18234173	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:18234173C>A	uc001rdq.2	-	6	764	c.570G>T	c.(568-570)ATG>ATT	p.M190I	RERGL_uc001rdr.2_Missense_Mutation_p.M189I	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	190	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						TCAATTTGGCCATTGATTTAG	0.363			NA											10	43					0.00621372	0.00669487	0.006214	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21011412	21011412	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:21011412C>G	uc001rek.2	+	4	392	c.266C>G	c.(265-267)TCT>TGT	p.S89C	SLCO1B3_uc001rel.2_Missense_Mutation_p.S89C|SLCO1B3_uc010sil.1_Missense_Mutation_p.S89C|LST-3TM12_uc010sim.1_Missense_Mutation_p.S89C	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	89	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TACTTTGGATCTAAACTACAC	0.318			NA											4	44					0	0	0.000602	0	0
KIF21A	55605	broad.mit.edu	37	12	39751210	39751210	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:39751210C>T	uc001rly.2	-	9	1391	c.1245G>A	c.(1243-1245)GTG>GTA	p.V415V	KIF21A_uc001rlx.2_Silent_p.V415V|KIF21A_uc001rlz.2_Silent_p.V415V|KIF21A_uc010skl.1_Silent_p.V415V|KIF21A_uc001rma.1_Silent_p.V423V	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	415	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TGATGCTTTCCACACCCTCTT	0.368			NA											30	55					0	0	0.004878	0	0
PLEKHA9	51054	broad.mit.edu	37	12	45567458	45567458	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:45567458C>A	uc001rom.1	-	3	1228	c.691G>T	c.(691-693)GAC>TAC	p.D231Y	PLEKHA9_uc009zke.2_Missense_Mutation_p.D231Y	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		CCAAGTTTGTCTAATACTGGA	0.383			NA											54	90					1.83081e-24	3.40307e-24	0.01441	1	0
ADCY6	112	broad.mit.edu	37	12	49170959	49170960	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:49170959_49170960CC>AA	uc001rsh.3	-	5	1963_1964	c.1303_1304GG>TT	c.(1303-1305)GGG>TTG	p.G435L	ADCY6_uc001rsj.3_Missense_Mutation_p.G435L|ADCY6_uc001rsi.3_Missense_Mutation_p.G435L|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	435	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CTCCGGCAGCCCTGACACACAG	0.559			NA											28	85					0	0	0.004672	0	0
KRT81	3887	broad.mit.edu	37	12	52685241	52685241	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:52685241G>T	uc001sab.2	-	1	59	c.9C>A	c.(7-9)TGC>TGA	p.C3*	KRT86_uc010snq.1_Intron|KRT86_uc009zmg.2_Intron|KRT81_uc001sac.2_Intron	NM_002281	NP_002272	Q14533	KRT81_HUMAN	keratin, hair, basic, 1	3	Head.					keratin filament	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ATCCTGATCCGCAGGTCATGA	0.657			NA											5	8					2.0095e-06	2.59582e-06	0.001984	1	0
GLS2	27165	broad.mit.edu	37	12	56865309	56865309	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:56865309C>T	uc001slj.2	-	18	2050	c.1771G>A	c.(1771-1773)GAG>AAG	p.E591K	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Missense_Mutation_p.E326K|GLS2_uc009zot.2_Missense_Mutation_p.E252K	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	591					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GACAGGGCCTCAGCTGCTGCC	0.502			NA											14	20					0	0	0.00245	0	0
CAND1	55832	broad.mit.edu	37	12	67691560	67691560	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:67691560G>T	uc001stn.2	+	6	1218	c.781G>T	c.(781-783)GTA>TTA	p.V261L	CAND1_uc001sto.2_5'Flank	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	261	HEAT 7.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCCTTTGGTGGTAAAATTTTG	0.264			NA											6	42					5.18039e-06	6.56992e-06	0.00308	1	0
NUP107	57122	broad.mit.edu	37	12	69084442	69084442	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:69084442G>T	uc001suf.2	+	4	334	c.219G>T	c.(217-219)CAG>CAT	p.Q73H	NUP107_uc001sug.2_5'UTR|NUP107_uc010stj.1_Missense_Mutation_p.Q44H	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	73					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TACTAAGGCAGCCAGATATTT	0.423			NA											19	48					2.39556e-15	3.94135e-15	0.00278	1	0
OSBPL8	114882	broad.mit.edu	37	12	76788492	76788492	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:76788492C>T	uc001sye.1	-	9	1170	c.690G>A	c.(688-690)GCG>GCA	p.A230A	OSBPL8_uc001syf.1_Silent_p.A188A|OSBPL8_uc001syg.1_Silent_p.A188A|OSBPL8_uc001syh.1_Silent_p.A205A	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	230	PH.				lipid transport		lipid binding			ovary(1)	1						TGGATCCAACCGCTTCACCTT	0.333			NA											11	26					0	0	0.008291	0	0
NEDD1	121441	broad.mit.edu	37	12	97328824	97328824	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:97328824T>C	uc001teu.3	+	7	899	c.560T>C	c.(559-561)GTA>GCA	p.V187A	NEDD1_uc001tev.3_Missense_Mutation_p.V187A|NEDD1_uc010svc.1_Missense_Mutation_p.V98A|NEDD1_uc001tew.2_Missense_Mutation_p.V194A|NEDD1_uc001tex.2_Missense_Mutation_p.V98A	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	187	WD 5.				cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						AATGGAATAGTAACTCTCTGG	0.373			NA											9	139					0	0	0.010729	0	0
SLC17A8	246213	broad.mit.edu	37	12	100796515	100796515	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:100796515A>G	uc010svi.1	+	8	1358	c.1045A>G	c.(1045-1047)ATA>GTA	p.I349V	SLC17A8_uc009ztx.2_Intron	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	349	Vesicular (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TGGATTTGCAATAAGTAAGGT	0.323			NA											12	16					0	0	0.001855	0	0
HCFC2	29915	broad.mit.edu	37	12	104492250	104492250	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:104492250A>T	uc001tkj.3	+	13	1973	c.1870A>T	c.(1870-1872)ATC>TTC	p.I624F	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	624	Fibronectin type-III 2.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						GAAGCAAAGCATCTCAAAGGT	0.343	Esophageal Squamous(184;1814 2036 4771 6974 15702)		NA											37	67					0	0	0.006999	0	0
CUX2	23316	broad.mit.edu	37	12	111785687	111785687	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:111785687G>T	uc001tsa.1	+	22	4172	c.4019G>T	c.(4018-4020)GGA>GTA	p.G1340V		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1340	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GGTAATGATGGACTCCCAAAA	0.637			NA											28	59					3.86903e-22	7.03066e-22	0.013726	1	0
ACAD10	80724	broad.mit.edu	37	12	112186168	112186168	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:112186168G>T	uc001tsq.2	+	17	2733	c.2533G>T	c.(2533-2535)GAC>TAC	p.D845Y	ACAD10_uc001tsp.2_Missense_Mutation_p.D845Y|ACAD10_uc009zvx.2_Missense_Mutation_p.D876Y|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	845							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GGGAAAAACAGACCCACATGC	0.532			NA											11	64					3.86212e-05	4.67874e-05	0.008291	1	0
OAS2	4939	broad.mit.edu	37	12	113416336	113416336	+	Translation_Start_Site	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:113416336C>A	uc001tuj.2	+	1	63	c.-77C>A	c.(-79--75)TCCTG>TCATG		OAS2_uc001tuh.2_Translation_Start_Site|OAS2_uc001tui.1_Translation_Start_Site	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1						interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						TTTCAGTTTCCTGGCTCTGGG	0.532	Pancreas(199;709 2232 18410 33584 35052)		NA											3	8					0.004672	0.00507871	0.004672	1	0
OAS2	4939	broad.mit.edu	37	12	113436106	113436106	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:113436106A>T	uc001tuj.2	+	5	1039	c.899A>T	c.(898-900)AAT>ATT	p.N300I	OAS2_uc001tui.1_Missense_Mutation_p.N300I	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	300	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						CCAACCAATAATGTGAGTGGA	0.413	Pancreas(199;709 2232 18410 33584 35052)		NA											69	80					0	0	0.01441	0	0
RASAL1	8437	broad.mit.edu	37	12	113552717	113552717	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:113552717G>A	uc001tum.1	-	13	1362	c.1069C>T	c.(1069-1071)CTC>TTC	p.L357F	RASAL1_uc010syp.1_Missense_Mutation_p.L357F|RASAL1_uc001tul.2_Missense_Mutation_p.L357F|RASAL1_uc001tun.1_Missense_Mutation_p.L357F|RASAL1_uc010syq.1_Missense_Mutation_p.L357F|RASAL1_uc001tuo.3_Missense_Mutation_p.L357F|RASAL1_uc010syr.1_Missense_Mutation_p.L357F	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	357	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						ATGCCCACGAGCTGGGGGCAG	0.637			NA											10	133					0	0	0.008291	0	0
FBXW8	26259	broad.mit.edu	37	12	117426644	117426644	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:117426644G>T	uc001twg.1	+	7	1291	c.1209G>T	c.(1207-1209)CAG>CAT	p.Q403H	FBXW8_uc001twf.1_Missense_Mutation_p.Q337H|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	403							protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		TTGGTGTACAGGGTCTGGGAT	0.448			NA											19	92					3.62473e-10	5.36548e-10	0.012319	1	0
BRI3BP	140707	broad.mit.edu	37	12	125509731	125509731	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:125509731G>A	uc001uha.1	+	3	654	c.511G>A	c.(511-513)GTG>ATG	p.V171M		NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	BRI3-binding protein	171						integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		CATGTCCTGCGTGTACATCCT	0.607			NA											14	76					0	0	0.001855	0	0
CHFR	55743	broad.mit.edu	37	12	133420622	133420622	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr12:133420622C>G	uc001ulf.2	-	16	1954	c.1870G>C	c.(1870-1872)GAG>CAG	p.E624Q	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.E612Q|CHFR_uc010tbs.1_Missense_Mutation_p.E623Q|CHFR_uc001uld.2_Missense_Mutation_p.E583Q|CHFR_uc010tbt.1_Missense_Mutation_p.E532Q	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	624					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CCTGGCAACTCGGAAGCAGGA	0.478			NA											6	18					0	0	0.001984	0	0
BRCA2	675	broad.mit.edu	37	13	32937423	32937423	+	Nonsense_Mutation	SNP	C	C	A	rs80359048		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr13:32937423C>A	uc001uub.1	+	18	8311	c.8084C>A	c.(8083-8085)TCA>TAA	p.S2695*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2695					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GACATAATTTCATTGAGCGCA	0.368	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			15	87					1.02788e-11	1.57911e-11	0.00499	1	0
TRPC4	7223	broad.mit.edu	37	13	38320279	38320279	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr13:38320279C>A	uc001uws.2	-	3	927	c.692G>T	c.(691-693)AGC>ATC	p.S231I	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.S231I|TRPC4_uc010tey.1_Missense_Mutation_p.S231I|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Missense_Mutation_p.S231I|TRPC4_uc010aby.2_Missense_Mutation_p.S231I	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	231	Potential.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTCCACCTTGCTCAGTTCCTG	0.463			NA											11	49					3.86212e-05	4.67874e-05	0.008291	1	0
CKAP2	26586	broad.mit.edu	37	13	53036058	53036058	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr13:53036058G>C	uc001vgv.2	+	4	1297	c.1100G>C	c.(1099-1101)AGA>ACA	p.R367T	CKAP2_uc001vgt.2_Missense_Mutation_p.R366T|CKAP2_uc001vgu.2_Missense_Mutation_p.R366T|CKAP2_uc010tha.1_Missense_Mutation_p.R318T	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	367					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		TCGGAAGAGAGAAAGTAAGTA	0.348			NA											9	31					0	0	0.004482	0	0
PCDH8	5100	broad.mit.edu	37	13	53418802	53418802	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr13:53418802G>T	uc001vhi.2	-	3	3309	c.3106C>A	c.(3106-3108)CCC>ACC	p.P1036T	PCDH8_uc001vhj.2_Missense_Mutation_p.P939T	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	1036	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CCTGGACGGGGAGGGGAGAGC	0.582	GBM(36;25 841 9273 49207)		NA											11	77					3.86212e-05	4.67874e-05	0.008291	1	0
TMTC4	84899	broad.mit.edu	37	13	101320951	101320951	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr13:101320951G>C	uc001vou.2	-	2	204	c.44C>G	c.(43-45)TCT>TGT	p.S15C	TMTC4_uc001vot.2_Missense_Mutation_p.S34C|TMTC4_uc010tja.1_Missense_Mutation_p.S15C	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	15	Helical; (Potential).					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGGAAGAACAGAAGATGGAAG	0.473			NA											11	43					0	0	0.008291	0	0
OR4N2	390429	broad.mit.edu	37	14	20296384	20296384	+	Silent	SNP	G	G	A	rs149732016	byFrequency	TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:20296384G>A	uc010tkv.1	+	1	777	c.777G>A	c.(775-777)ACG>ACA	p.T259T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCATCTACACGCGCCCCTTCA	0.468			NA											15	83					0	0	0.00245	0	0
CTSG	1511	broad.mit.edu	37	14	25044512	25044512	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:25044512C>A	uc001wpq.2	-	2	199	c.162G>T	c.(160-162)GTG>GTT	p.V54V		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	54	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		AGTCTTCTCGCACCAGGAACC	0.602			NA											7	56					8.12818e-05	9.60783e-05	0.001984	1	0
EGLN3	112399	broad.mit.edu	37	14	34396240	34396240	+	Splice_Site	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:34396240C>A	uc001wsa.3	-	4	941	c.615_splice	c.e4-1	p.R205_splice	EGLN3_uc001wry.2_Splice_Site_p.R111_splice|EGLN3_uc001wrz.2_Splice_Site_p.R205_splice	NM_022073	NP_071356	Q9H6Z9	EGLN3_HUMAN	egl nine homolog 3						apoptosis	cytoplasm|nucleus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding				0	Breast(36;0.0303)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.000246)|Lung(238;0.000959)|Epithelial(34;0.155)	GBM - Glioblastoma multiforme(112;0.0118)	Vitamin C(DB00126)	CATAGCATATCTGTGAAAGAT	0.313	Esophageal Squamous(161;245 1904 13895 22565 30076)		NA											6	49					0.00307968	0.00339322	0.00308	1	0
MDGA2	161357	broad.mit.edu	37	14	47346708	47346708	+	Silent	SNP	A	A	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:47346708A>C	uc001wwj.3	-	12	2410	c.2214T>G	c.(2212-2214)CCT>CCG	p.P738P	MDGA2_uc001wwh.3_Intron|MDGA2_uc001wwi.3_Silent_p.P509P|MDGA2_uc010ani.2_Silent_p.P298P	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	738					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GAGGATTTACAGGAGCTACAA	0.224			NA											3	3					0	0	0.004672	0	0
SPTB	6710	broad.mit.edu	37	14	65271709	65271709	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:65271709C>A	uc001xht.2	-	2	302	c.248G>T	c.(247-249)CGG>CTG	p.R83L	SPTB_uc001xhr.2_Missense_Mutation_p.R83L|SPTB_uc001xhs.2_Missense_Mutation_p.R83L|SPTB_uc001xhu.2_Missense_Mutation_p.R83L	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	83	CH 1.|Actin-binding.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCGCCCATCCCGCAGGTCCTT	0.587			NA											17	53					0.000422831	0.000482246	0.004007	1	0
ISM2	145501	broad.mit.edu	37	14	77942014	77942014	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:77942014T>A	uc001xtz.2	-	7	1714	c.1640A>T	c.(1639-1641)AAC>ATC	p.N547I	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.N459I|ISM2_uc010tvl.1_Missense_Mutation_p.N466I	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	547	AMOP.					extracellular region				skin(1)	1						TCGGCCGTTGTTGGGAGGGAG	0.607			NA											11	24					0	0	0.008291	0	0
ITPK1	3705	broad.mit.edu	37	14	93408241	93408241	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:93408241C>A	uc001ybg.2	-	11	1199	c.910G>T	c.(910-912)GGC>TGC	p.G304C	ITPK1_uc001ybe.2_Intron|ITPK1_uc001ybf.2_Missense_Mutation_p.G185C|ITPK1_uc001ybh.2_Missense_Mutation_p.G304C	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	304	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		TCGCTCACGCCCTCGTAGCCT	0.652			NA											8	8					0.00621372	0.00669487	0.006214	1	0
WARS	7453	broad.mit.edu	37	14	100803403	100803403	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:100803403C>A	uc001yhf.1	-	9	1334	c.1250G>T	c.(1249-1251)AGG>ATG	p.R417M	WARS_uc001yhe.1_Missense_Mutation_p.R223M|WARS_uc001yhg.1_Missense_Mutation_p.R417M|WARS_uc001yhh.1_Missense_Mutation_p.R417M|WARS_uc001yhi.1_Missense_Mutation_p.R376M|WARS_uc001yhj.1_Missense_Mutation_p.R376M|WARS_uc001yhk.1_Missense_Mutation_p.R376M|WARS_uc001yhl.1_Missense_Mutation_p.R417M	NM_173701	NP_776049	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase isoform a	417					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(1)	1		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	GCTCACCTTCCTGATCTGCTC	0.602			NA											13	96					3.41278e-10	5.06715e-10	0.00499	1	0
AHNAK2	113146	broad.mit.edu	37	14	105410286	105410286	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr14:105410286C>A	uc010axc.1	-	7	11622	c.11502G>T	c.(11500-11502)GAG>GAT	p.E3834D	AHNAK2_uc001ypx.2_Missense_Mutation_p.E3734D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3834						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCACATCGGCCTCCACCTTGG	0.592			NA											42	127					3.61848e-18	6.29357e-18	0.007835	1	0
NIPA1	123606	broad.mit.edu	37	15	23048984	23048984	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:23048984G>C	uc001yvc.2	-	5	860	c.835C>G	c.(835-837)CTC>GTC	p.L279V	NIPA1_uc001yvd.2_Missense_Mutation_p.L109V|NIPA1_uc001yve.2_Missense_Mutation_p.L204V	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	279	Helical; (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		TCCCGGAAGAGGATGGCTGAG	0.582			NA											4	19					0	0	0.009096	0	0
GABRB3	2562	broad.mit.edu	37	15	26812850	26812850	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:26812850C>A	uc001zaz.2	-	7	855	c.713G>T	c.(712-714)CGG>CTG	p.R238L	GABRB3_uc010uae.1_Missense_Mutation_p.R153L|GABRB3_uc001zba.2_Missense_Mutation_p.R238L|GABRB3_uc001zbb.2_Missense_Mutation_p.R294L	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	238	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCTCTTCAACCGAAAGCTCAG	0.423			NA											6	48					2.0095e-06	2.59582e-06	0.001984	1	0
OCA2	4948	broad.mit.edu	37	15	28196981	28196981	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:28196981T>A	uc001zbh.3	-	18	2010	c.1900A>T	c.(1900-1902)ATC>TTC	p.I634F	OCA2_uc010ayv.2_Missense_Mutation_p.I610F	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	634	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AACATGAAGATAACAAATCCC	0.428			NA							Oculocutaneous_Albinism				8	30					0	0	0.006214	0	0
HERC2	8924	broad.mit.edu	37	15	28422209	28422209	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:28422209C>A	uc001zbj.2	-	61	9425	c.9319G>T	c.(9319-9321)GGG>TGG	p.G3107W		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3107	RCC1 8.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGCGAGCTCCCACAGGCGATA	0.562			NA											7	36					8.12818e-05	9.60783e-05	0.001984	1	0
RYR3	6263	broad.mit.edu	37	15	33603291	33603291	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:33603291G>T	uc001zhi.2	+	1	115	c.45G>T	c.(43-45)CTG>CTT	p.L15L	RYR3_uc010bar.2_Silent_p.L15L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	15	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCAGTTTCTGAGGACTGTGA	0.756			NA											8	13					0.00448238	0.00491649	0.004482	1	0
COPS2	9318	broad.mit.edu	37	15	49426281	49426281	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:49426281C>G	uc001zxf.2	-	8	819	c.740G>C	c.(739-741)AGG>ACG	p.R247T	COPS2_uc001zxh.2_Missense_Mutation_p.R254T|COPS2_uc010ufa.1_Missense_Mutation_p.R183T	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	247					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		TTCACCTTCCCTCAAGTGCAT	0.358	NSCLC(36;322 1063 10349 30082 48062)|Esophageal Squamous(122;685 1633 15569 21293 52803)		NA											12	47					0	0	0.001855	0	0
CYP19A1	1588	broad.mit.edu	37	15	51507397	51507397	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:51507397G>T	uc001zyz.3	-	9	1142	c.891C>A	c.(889-891)AAC>AAA	p.N297K	CYP19A1_uc001zza.3_Missense_Mutation_p.N297K|CYP19A1_uc001zzb.2_Missense_Mutation_p.N297K	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	297					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	ATATGCACTGGTTCACATTCT	0.413	Melanoma(142;1016 1807 39614 48966 51721)		NA											10	78					1.33987e-11	2.04551e-11	0.008291	1	0
DMXL2	23312	broad.mit.edu	37	15	51755682	51755682	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:51755682G>A	uc002abf.2	-	33	8042	c.7817C>T	c.(7816-7818)TCT>TTT	p.S2606F	DMXL2_uc002abd.2_Missense_Mutation_p.S677F|DMXL2_uc010ufy.1_Missense_Mutation_p.S2607F|DMXL2_uc010bfa.2_Missense_Mutation_p.S1970F	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2606						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		AAATGCAGAAGAATCCCGGGA	0.294			NA											16	97					0	0	0.007413	0	0
MAP2K1	5604	broad.mit.edu	37	15	66727441	66727441	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:66727441T>C	uc010bhq.2	+	2	632	c.157T>C	c.(157-159)TTT>CTT	p.F53L	MAP2K1_uc010ujp.1_Missense_Mutation_p.F31L	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	53			F -> S (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CCTTGAGGCCTTTCTTACCCA	0.547			NA							Cardiofaciocutaneous_syndrome				46	104					0	0	0.01441	0	0
LCTL	197021	broad.mit.edu	37	15	66850109	66850109	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:66850109G>T	uc002aqc.2	-	8	1005	c.873C>A	c.(871-873)GCC>GCA	p.A291A	LCTL_uc002aqd.3_Silent_p.A118A|LCTL_uc010bhw.2_5'UTR	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	291	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						AAATGGGGTTGGCAAACCAGC	0.498			NA											34	70					1.60099e-16	2.67014e-16	0.004878	1	0
PTPN9	5780	broad.mit.edu	37	15	75815560	75815560	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:75815560G>A	uc002bal.2	-	4	832	c.324C>T	c.(322-324)TCC>TCT	p.S108S		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	108	CRAL-TRIO.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						AGAGGGCAATGGAGGCTCCTG	0.403			NA											10	30					0	0	0.008291	0	0
CSPG4	1464	broad.mit.edu	37	15	75981627	75981627	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:75981627C>G	uc002baw.2	-	3	1872	c.1779G>C	c.(1777-1779)CAG>CAC	p.Q593H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	593	Extracellular (Potential).|CSPG 2.|Globular or compact configuration stabilized by disulfide bonds.|Interaction with COL6A2 (By similarity).|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TGCCAAGGACCTGGAAGGTGA	0.672			NA											6	20					0	0	0.001984	0	0
SCAPER	49855	broad.mit.edu	37	15	77087629	77087629	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:77087629C>T	uc002bby.2	-	7	823	c.764G>A	c.(763-765)CGC>CAC	p.R255H	SCAPER_uc002bbx.2_5'UTR|SCAPER_uc002bbz.1_Missense_Mutation_p.R120H|SCAPER_uc002bca.1_Missense_Mutation_p.R120H|SCAPER_uc002bcb.1_Missense_Mutation_p.R255H|SCAPER_uc002bcc.1_Missense_Mutation_p.R255H	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	254						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						GCCATTTTTGCGTGAGGCCTT	0.408			NA											15	97					0	0	0.006122	0	0
NTRK3	4916	broad.mit.edu	37	15	88483959	88483959	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:88483959G>A	uc002bme.1	-	14	1773	c.1611C>T	c.(1609-1611)GAC>GAT	p.D537D	NTRK3_uc002bmh.2_Silent_p.D529D|NTRK3_uc002bmf.1_Silent_p.D537D|NTRK3_uc010upl.1_Silent_p.D439D|NTRK3_uc010bnh.1_Silent_p.D529D	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	537	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCAGCACGATGTCTCTCCTCT	0.537			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			13	102					0	0	0.00245	0	0
ACAN	176	broad.mit.edu	37	15	89392759	89392759	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr15:89392759C>A	uc010upo.1	+	10	2197	c.1823C>A	c.(1822-1824)ACG>AAG	p.T608K	ACAN_uc002bmx.2_Missense_Mutation_p.T608K|ACAN_uc010upp.1_Missense_Mutation_p.T608K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	608					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGCCACCACGGGCCAGCTC	0.652			NA											4	10					0.00024832	0.000285217	0.009096	1	0
MSLN	10232	broad.mit.edu	37	16	816697	816697	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:816697G>T	uc002cjw.1	+	13	1335	c.1284G>T	c.(1282-1284)AAG>AAT	p.K428N	MSLN_uc002cjt.1_Missense_Mutation_p.K420N|MSLN_uc002cju.1_Missense_Mutation_p.K420N|MSLN_uc010brd.1_Missense_Mutation_p.K419N|MSLN_uc002cjv.1_Missense_Mutation_p.K420N|MSLN_uc002cjx.1_Missense_Mutation_p.K420N|MSLN_uc002cjy.1_Missense_Mutation_p.K85N	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	428					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GCTTTGTGAAGGGAAGGGGCC	0.632			NA											20	43					4.35082e-09	6.12384e-09	0.010504	1	0
NLRC3	197358	broad.mit.edu	37	16	3614682	3614682	+	Silent	SNP	T	T	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:3614682T>G	uc010btn.2	-	5	667	c.256A>C	c.(256-258)AGG>CGG	p.R86R		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	86					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GAGGCCAGCCTGTGCCAGGGT	0.706			NA											5	8					0	0	0.000602	0	0
ITGAL	3683	broad.mit.edu	37	16	30510692	30510692	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:30510692A>T	uc002dyi.3	+	17	2203	c.2027A>T	c.(2026-2028)CAG>CTG	p.Q676L	ITGAL_uc002dyj.3_Missense_Mutation_p.Q593L|ITGAL_uc010vev.1_Missense_Mutation_p.Q72L	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	676	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	TACACTCTGCAGCTGGATGGC	0.567	NSCLC(110;1462 1641 3311 33990 49495)		NA											22	75					0	0	0.00333	0	0
ZNF688	146542	broad.mit.edu	37	16	30581633	30581633	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:30581633G>A	uc002dyt.2	-	3	1213	c.435C>T	c.(433-435)AGC>AGT	p.S145S	ZNF688_uc002dys.2_Silent_p.S131S|uc002dyu.2_5'Flank	NM_145271	NP_660314	P0C7X2	ZN688_HUMAN	zinc finger protein 688 isoform a	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGGGGCCACGCTAATAGCTG	0.627			NA											6	35					0	0	0.001168	0	0
ZNF423	23090	broad.mit.edu	37	16	49660112	49660112	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:49660112C>G	uc002efs.2	-	6	3844	c.3546G>C	c.(3544-3546)GAG>GAC	p.E1182D	ZNF423_uc010vgn.1_Missense_Mutation_p.E1065D	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1182	C2H2-type 27.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGATTTGGATCTCTCTCTCGT	0.443			NA											38	149					0	0	0.010771	0	0
ZNF423	23090	broad.mit.edu	37	16	49670744	49670744	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:49670744G>T	uc002efs.2	-	5	2617	c.2319C>A	c.(2317-2319)CAC>CAA	p.H773Q	ZNF423_uc010vgn.1_Missense_Mutation_p.H656Q	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	773	C2H2-type 18.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGTTGCCCAGGTGGCTGTGTT	0.587			NA											8	30					0.00307968	0.00339322	0.00308	1	0
NKD1	85407	broad.mit.edu	37	16	50642220	50642220	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:50642220G>T	uc002egg.1	+	4	432	c.208G>T	c.(208-210)GTG>TTG	p.V70L		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	70					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		CGTGGGCGACGTGTTGAGAGA	0.592			NA											21	89					1.90627e-21	3.43834e-21	0.012319	1	0
CHD9	80205	broad.mit.edu	37	16	53341597	53341597	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:53341597G>T	uc002ehb.2	+	32	6949	c.6785G>T	c.(6784-6786)CGT>CTT	p.R2262L	CHD9_uc002egy.2_Missense_Mutation_p.R2262L|CHD9_uc002ehc.2_Missense_Mutation_p.R2263L|CHD9_uc002ehf.2_Missense_Mutation_p.R1376L|CHD9_uc010cbw.2_Missense_Mutation_p.R328L|CHD9_uc002ehg.1_Missense_Mutation_p.R269L	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2262					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TTCTAGGATCGTGTGATGATC	0.378			NA											4	9					0.00024832	0.000285217	0.009096	1	0
NFATC3	4775	broad.mit.edu	37	16	68224795	68224795	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:68224795G>T	uc002evo.1	+	9	2433	c.2223G>T	c.(2221-2223)CTG>CTT	p.L741L	NFATC3_uc010vkl.1_Silent_p.L262L|NFATC3_uc010vkm.1_Silent_p.L262L|NFATC3_uc010vkn.1_Silent_p.L262L|NFATC3_uc010vko.1_Silent_p.L262L|NFATC3_uc010vkp.1_Silent_p.L262L|NFATC3_uc010vkq.1_Silent_p.L262L|NFATC3_uc002evl.2_Silent_p.L262L|NFATC3_uc002evk.2_Silent_p.L741L|NFATC3_uc002evm.1_Silent_p.L741L|NFATC3_uc002evn.1_Silent_p.L741L|NFATC3_uc010vkr.1_Silent_p.L262L|NFATC3_uc010vks.1_Silent_p.L262L|NFATC3_uc010vkt.1_Silent_p.L262L|NFATC3_uc010vku.1_Silent_p.L262L|NFATC3_uc010vkv.1_Silent_p.L262L|NFATC3_uc010vkw.1_Silent_p.L262L|NFATC3_uc010vkx.1_Silent_p.L262L|NFATC3_uc010vky.1_Silent_p.L262L|NFATC3_uc010vkz.1_Silent_p.L262L|NFATC3_uc010vla.1_Silent_p.L262L|NFATC3_uc010vlb.1_Silent_p.L262L|NFATC3_uc010vlc.1_Silent_p.L262L	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	741					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		ACAGTGTACTGTCAGGACAGA	0.473			NA											21	71					0.000175454	0.000203929	0.010504	1	0
SF3B3	23450	broad.mit.edu	37	16	70605714	70605715	+	Nonstop_Mutation	DNP	TG	TG	CT			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:70605714_70605715TG>CT	uc002ezf.2	+	26	3863_3864	c.3652_3653TG>CT	c.(3652-3654)TGA>CTA	p.*1218L		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1218					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CTACGCCTTCTGAGCCCTCCTT	0.564			NA											9	36					0	0	0.004672	0	0
ZNF19	7567	broad.mit.edu	37	16	71509360	71509360	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:71509360T>C	uc010cgc.1	-	6	1596	c.1090A>G	c.(1090-1092)AAA>GAA	p.K364E	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.K352E|ZNF19_uc002fal.1_Missense_Mutation_p.K352E|ZNF19_uc002fam.1_Missense_Mutation_p.K364E	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	364	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		CTGAAGGCTTTTCCACAATCT	0.403			NA											11	64					0	0	0.008291	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77356285	77356285	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:77356285C>A	uc002ffc.3	-	14	2530	c.2111G>T	c.(2110-2112)GGA>GTA	p.G704V	ADAMTS18_uc010chc.1_Missense_Mutation_p.G292V|ADAMTS18_uc002ffe.1_Missense_Mutation_p.G400V	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	704	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GCAGGGAGTTCCATCTTTCAC	0.398			NA											14	141					0.000219431	0.000254436	0.00245	1	0
PKD1L2	114780	broad.mit.edu	37	16	81232459	81232459	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:81232459A>T	uc002fgh.1	-	7	1351	c.1351T>A	c.(1351-1353)TCA>ACA	p.S451T	PKD1L2_uc002fgj.2_Missense_Mutation_p.S451T	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	451	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGCAGCCCTGACAGCAGCTCC	0.582			NA											40	92					0	0	0.005524	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050277	84050277	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:84050277C>A	uc002fhg.1	-	8	1009	c.1009G>T	c.(1009-1011)GCC>TCC	p.A337S		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	337					amino acid transport|sodium ion transport	integral to membrane					0						TCGGCCAGGGCGCTGGGCCCC	0.657			NA											13	40					0.000151284	0.00017668	0.001855	1	0
SLC38A8	146167	broad.mit.edu	37	16	84050766	84050766	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:84050766G>C	uc002fhg.1	-	7	932	c.932C>G	c.(931-933)CCC>CGC	p.P311R		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	311	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						GAGCACGATGGGGTAGACAGT	0.532			NA											4	24					0	0	0.009096	0	0
MTHFSD	64779	broad.mit.edu	37	16	86582141	86582141	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:86582141C>A	uc002fjn.2	-	4	331	c.280G>T	c.(280-282)GGA>TGA	p.G94*	MTHFSD_uc010voo.1_Nonsense_Mutation_p.G74*|MTHFSD_uc002fjo.2_5'UTR|MTHFSD_uc002fjm.2_Nonsense_Mutation_p.G93*|MTHFSD_uc010vop.1_5'UTR|MTHFSD_uc010voq.1_Nonsense_Mutation_p.G93*|MTHFSD_uc010vor.1_Nonsense_Mutation_p.G94*|MTHFSD_uc002fjp.2_Nonsense_Mutation_p.G74*	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	94					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						TTAAACAATCCCGTTCTCAGT	0.388			NA											26	92					1.50538e-07	2.04782e-07	0.00632	1	0
CBFA2T3	863	broad.mit.edu	37	16	88951655	88951655	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr16:88951655G>T	uc002fmm.1	-	7	1102	c.916C>A	c.(916-918)CGC>AGC	p.R306S	CBFA2T3_uc002fml.1_Missense_Mutation_p.R220S|CBFA2T3_uc010cif.1_Missense_Mutation_p.R245S|CBFA2T3_uc002fmn.1_Missense_Mutation_p.R281S	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	306	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).		R -> H (in a colorectal cancer sample; somatic mutation).		cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R306H(1)		large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		AGCGGGTCGCGGTCTGACCCG	0.677			NA	T	RUNX1	AML								6	11					0.00198382	0.0022108	0.001984	1	0
AIPL1	23746	broad.mit.edu	37	17	6330265	6330265	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:6330265C>A	uc002gcp.2	-	4	673	c.578G>T	c.(577-579)CGC>CTC	p.R193L	AIPL1_uc002gcq.2_Missense_Mutation_p.R133L|AIPL1_uc002gcr.2_Missense_Mutation_p.R130L|AIPL1_uc010clk.2_Missense_Mutation_p.R171L|AIPL1_uc010cll.2_Missense_Mutation_p.R193L|AIPL1_uc002gcs.2_Missense_Mutation_p.R193L	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	193	TPR 1.				protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		CTCCTCGTAGCGGCCCAGCTT	0.597			NA											51	49					9.52127e-25	1.77657e-24	0.01441	1	0
USP43	124739	broad.mit.edu	37	17	9578299	9578299	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:9578299A>T	uc010cod.2	+	4	832	c.832A>T	c.(832-834)AGG>TGG	p.R278W	USP43_uc002gma.3_5'UTR|USP43_uc010vva.1_Missense_Mutation_p.R278W|USP43_uc010coe.2_Missense_Mutation_p.R75W	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	278					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCGCCAGACGAGGTACGTGAG	0.537			NA											76	93					0	0	0.01441	0	0
MYH4	4622	broad.mit.edu	37	17	10366242	10366242	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:10366242G>T	uc002gmn.2	-	11	1059	c.948C>A	c.(946-948)GTC>GTA	p.V316V	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	316	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCCCTTGGCTGACAAATGCGA	0.393			NA											38	37					9.9191e-30	1.8651e-29	0.00874	1	0
MYH1	4619	broad.mit.edu	37	17	10417165	10417165	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:10417165G>T	uc002gmo.2	-	8	808	c.714C>A	c.(712-714)ACC>ACA	p.T238T	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	238	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CATTCCTCACGGTCTTGGCGT	0.502			NA											28	23					3.11337e-16	5.17479e-16	0.013726	1	0
MYH2	4620	broad.mit.edu	37	17	10446451	10446451	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:10446451T>A	uc010coi.2	-	9	897	c.769A>T	c.(769-771)ACT>TCT	p.T257S	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.T257S|MYH2_uc010coj.2_Missense_Mutation_p.T257S	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	257	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTTCCAGTAGTGCCAAAGTGG	0.279			NA											19	92					0	0	0.014323	0	0
MYH2	4620	broad.mit.edu	37	17	10447283	10447283	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:10447283T>C	uc010coi.2	-	7	712	c.584A>G	c.(583-585)TAC>TGC	p.Y195C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.Y195C|MYH2_uc010coj.2_Missense_Mutation_p.Y195C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	195	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGTTGCAAAGTACTGGATGAC	0.433			NA											13	75					0	0	0.013537	0	0
MYH3	4621	broad.mit.edu	37	17	10535312	10535312	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:10535312C>G	uc002gmq.1	-	34	5055	c.4978G>C	c.(4978-4980)GAT>CAT	p.D1660H		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1660	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CGGAGGGCATCATCCAGGTGG	0.562			NA											21	20					0	0	0.014323	0	0
NF1	4763	broad.mit.edu	37	17	29663445	29663445	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:29663445C>T	uc002hgg.2	+	41	6434	c.6101C>T	c.(6100-6102)ACT>ATT	p.T2034I	NF1_uc002hgh.2_Missense_Mutation_p.T2013I|NF1_uc010cso.2_Missense_Mutation_p.T222I|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2034					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGGCAGATACTGCTGTAGCT	0.393			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			15	62					0	0	0.00499	0	0
KRTAP3-3	85293	broad.mit.edu	37	17	39150336	39150336	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:39150336G>A	uc002hvr.1	-	1	50	c.14C>T	c.(13-15)GCC>GTC	p.A5V		NM_033185	NP_149441	Q9BYR6	KRA33_HUMAN	keratin associated protein 3-3	5	1.|3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity				0		Breast(137;0.00043)				GCCTCGAGAGGCACAGCAATC	0.547			NA											31	84					0	0	0.009535	0	0
OSBPL7	114881	broad.mit.edu	37	17	45886818	45886818	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:45886818T>A	uc002ilx.1	-	19	2110	c.1907A>T	c.(1906-1908)AAG>ATG	p.K636M	OSBPL7_uc002ilw.1_Missense_Mutation_p.K198M	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	636					lipid transport		lipid binding				0						GGATGTCACCTTGTTCCACTC	0.567			NA											10	27					0	0	0.010729	0	0
BCAS3	54828	broad.mit.edu	37	17	58946045	58946045	+	Splice_Site	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:58946045G>T	uc002iyv.3	+	8	693	c.584_splice	c.e8+1	p.R195_splice	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Splice_Site_p.R195_splice|BCAS3_uc002iyw.3_Splice_Site_p.R191_splice	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1							nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GCAATAAACGGTAAGGATTTT	0.373			NA											10	37					2.17888e-05	2.68636e-05	0.006214	1	0
NACA2	342538	broad.mit.edu	37	17	59668525	59668525	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:59668525G>T	uc002izj.2	-	1	43	c.17C>A	c.(16-18)ACA>AAA	p.T6K		NM_199290	NP_954984	Q9H009	NACA2_HUMAN	nascent-polypeptide-associated complex alpha	6					protein transport	cytoplasm|nucleus				ovary(1)	1	all_epithelial(1;3.12e-14)					GACGGTTTCTGTGGCTTCGCC	0.582			NA											11	26					2.27111e-07	3.0638e-07	0.013537	1	0
KCNJ2	3759	broad.mit.edu	37	17	68172048	68172048	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:68172048G>A	uc010dfg.2	+	2	1269	c.868G>A	c.(868-870)GCA>ACA	p.A290T	KCNJ2_uc002jir.2_Missense_Mutation_p.A290T	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	290	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					CATTGACAACGCAGACTTTGA	0.438			NA											7	69					0	0	0.004482	0	0
QRICH2	84074	broad.mit.edu	37	17	74289961	74289961	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:74289961G>A	uc002jrd.1	-	4	529	c.349C>T	c.(349-351)CGG>TGG	p.R117W	QRICH2_uc010wsz.1_Missense_Mutation_p.R43W|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	117							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						GATGCAGTCCGATCCGGGCCA	0.557			NA											9	49					0	0	0.004482	0	0
CD7	924	broad.mit.edu	37	17	80274796	80274796	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:80274796G>A	uc002kel.1	-	2	253	c.144C>T	c.(142-144)TGC>TGT	p.C48C	CD7_uc010din.2_Silent_p.C48C|CD7_uc002kem.2_Missense_Mutation_p.L30F|CD7_uc010wvk.1_Silent_p.C48C	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	48	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			CGCTGGTGGAGCAGGTGATGT	0.642	Pancreas(45;804 1068 19702 28207 28798)		NA											7	28					0	0	0.004482	0	0
COLEC12	81035	broad.mit.edu	37	18	348117	348117	+	Silent	SNP	G	G	C	rs143313397		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:348117G>C	uc002kkm.2	-	4	443	c.228C>G	c.(226-228)CGC>CGG	p.R76R		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	76	Potential.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CATAGGTTTGGCGAGATGTTT	0.363			NA											23	66					0	0	0.005443	0	0
CEP192	55125	broad.mit.edu	37	18	13049430	13049430	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:13049430G>T	uc010xac.1	+	16	2720	c.2640G>T	c.(2638-2640)AAG>AAT	p.K880N	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.K405N|CEP192_uc002kru.2_RNA|CEP192_uc002krs.1_Missense_Mutation_p.K621N	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	880										ovary(4)|pancreas(1)	5						TTGATGTGAAGACATGTTCCA	0.363			NA											18	79					7.07596e-05	8.44606e-05	0.006122	1	0
ZNF521	25925	broad.mit.edu	37	18	22804890	22804890	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:22804890G>A	uc002kvk.2	-	4	3239	c.2992C>T	c.(2992-2994)CAG>TAG	p.Q998*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.Q998*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.Q778*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	998					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCTTCACTCTGGAGAGGCATC	0.493			NA	T	PAX5	ALL								13	39					0	0	0.001855	0	0
ZNF521	25925	broad.mit.edu	37	18	22806795	22806795	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:22806795G>C	uc002kvk.2	-	4	1334	c.1087C>G	c.(1087-1089)CTC>GTC	p.L363V	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.L363V|ZNF521_uc002kvl.2_Missense_Mutation_p.L143V	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	363					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCCACTGAGAGGTTGGAATCT	0.582			NA	T	PAX5	ALL								9	51					0	0	0.004482	0	0
CDH2	1000	broad.mit.edu	37	18	25543368	25543368	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:25543368G>T	uc002kwg.2	-	15	2926	c.2467C>A	c.(2467-2469)CGA>AGA	p.R823R	CDH2_uc010xbn.1_Silent_p.R792R	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	823	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GCTGCAGATCGGACCGGATAC	0.522			NA											8	20					2.17888e-05	2.68636e-05	0.006214	1	0
DSG4	147409	broad.mit.edu	37	18	28979267	28979267	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:28979267G>T	uc002kwq.2	+	9	1173	c.1038G>T	c.(1036-1038)CAG>CAT	p.Q346H	DSG4_uc002kwr.2_Missense_Mutation_p.Q346H	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	346	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTAACATTCAGCTTAGTATCG	0.373			NA											26	90					3.7963e-18	6.55603e-18	0.00333	1	0
C18orf34	374864	broad.mit.edu	37	18	30803130	30803130	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:30803130T>A	uc002kxn.2	-	17	2014	c.1872A>T	c.(1870-1872)AAA>AAT	p.K624N	C18orf34_uc010dme.1_Missense_Mutation_p.K138N|C18orf34_uc010xbr.1_Missense_Mutation_p.K624N|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Intron|C18orf34_uc002kxp.2_Missense_Mutation_p.K624N	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	624										ovary(1)	1						TTTTCTTTACTTTTCCCACCT	0.299			NA											8	44					0	0	0.008291	0	0
CDH19	28513	broad.mit.edu	37	18	64172379	64172379	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr18:64172379G>A	uc002lkc.1	-	12	2127	c.1989C>T	c.(1987-1989)ACC>ACT	p.T663T	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	663	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CCCGCATTATGGTACTACTCC	0.463			NA											72	180					0	0	0.01441	0	0
MUC16	94025	broad.mit.edu	37	19	9024488	9024488	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:9024488G>T	uc002mkp.2	-	17	37249	c.37045C>A	c.(37045-37047)CAT>AAT	p.H12349N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12351	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGCTCTGATGGGTGAAACCT	0.537			NA											11	17					4.36969e-10	6.4486e-10	0.001855	1	0
MUC16	94025	broad.mit.edu	37	19	9059194	9059194	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:9059194C>A	uc002mkp.2	-	3	28456	c.28252G>T	c.(28252-28254)GAT>TAT	p.D9418Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9420	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATGACACATCCTCAGGACCT	0.512			NA											36	52					1.414e-09	2.02535e-09	0.003755	1	0
KEAP1	9817	broad.mit.edu	37	19	10610099	10610099	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:10610099C>G	uc002moq.1	-	2	767	c.611G>C	c.(610-612)CGG>CCG	p.R204P	KEAP1_uc002mor.1_Missense_Mutation_p.R204P	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	204	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GATGTACTCCCGGGCACGCTG	0.597			NA											5	3					0	0	0.000602	0	0
ZNF44	51710	broad.mit.edu	37	19	12384274	12384274	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:12384274T>A	uc010xmj.1	-	5	1145	c.940A>T	c.(940-942)AGT>TGT	p.S314C	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.S266C	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	314	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		AGATATGAACTGTAATCAGGG	0.413			NA											26	54					0	0	0.003954	0	0
OR1I1	126370	broad.mit.edu	37	19	15198003	15198003	+	Missense_Mutation	SNP	G	G	T	rs138224343		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:15198003G>T	uc010xoe.1	+	1	127	c.127G>T	c.(127-129)GCC>TCC	p.A43S		NM_001004713	NP_001004713	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3						CATTGGAAATGCCCTCATTAT	0.493			NA											3	26					0.004672	0.00507871	0.004672	1	0
SLC5A5	6528	broad.mit.edu	37	19	17988585	17988585	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:17988585G>T	uc002nhr.3	+	6	1099	c.752G>T	c.(751-753)GGC>GTC	p.G251V		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	251	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GTGGTGGGTGGCACGTTGGTG	0.592	Melanoma(65;1008 1708 7910 46650)		NA											28	47					1.16021e-09	1.67662e-09	0.007291	1	0
ZNF676	163223	broad.mit.edu	37	19	22362965	22362965	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:22362965C>T	uc002nqs.1	-	3	1872	c.1554G>A	c.(1552-1554)TCG>TCA	p.S518S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	518	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CAGTAAGGATCGAGGACCAGC	0.403			NA											17	51					0	0	0.00499	0	0
ZNF91	7644	broad.mit.edu	37	19	23545221	23545221	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:23545221C>G	uc002nre.2	-	4	673	c.560G>C	c.(559-561)TGT>TCT	p.C187S	ZNF91_uc010xrj.1_Missense_Mutation_p.C155S	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	187	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGACTTGACACATTTTTTACA	0.289			NA											12	43					0	0	0.013537	0	0
ZNF536	9745	broad.mit.edu	37	19	31040344	31040344	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:31040344C>T	uc002nsu.1	+	4	3956	c.3818C>T	c.(3817-3819)TCT>TTT	p.S1273F	ZNF536_uc010edd.1_Missense_Mutation_p.S1273F	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCTACAGTTCTGATGGCTTA	0.557			NA											4	53					0	0	0.001984	0	0
SLC7A9	11136	broad.mit.edu	37	19	33350773	33350773	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:33350773G>A	uc002ntv.3	-	8	964	c.847C>T	c.(847-849)CTC>TTC	p.L283F	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Missense_Mutation_p.L283F|SLC7A9_uc002ntw.3_Missense_Mutation_p.L74F	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	283	Extracellular (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	GACTGCAGGAGTTCGGTGGCA	0.617	GBM(181;1335 2108 9644 44178 46689)		NA											4	44					0	0	0.009096	0	0
MAG	4099	broad.mit.edu	37	19	35791291	35791291	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:35791291G>T	uc002nyy.1	+	6	1103	c.954G>T	c.(952-954)GTG>GTT	p.V318V	MAG_uc002nyx.1_Silent_p.V318V|MAG_uc010eds.1_Silent_p.V293V|MAG_uc002nyz.1_Silent_p.V318V	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	318	Ig-like C2-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			ACCGCACCGTGGGGCTCAGTG	0.652			NA											8	18					5.18039e-06	6.56992e-06	0.00308	1	0
NFKBID	84807	broad.mit.edu	37	19	36380868	36380868	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:36380868C>A	uc002oci.1	-	11	1386	c.812G>T	c.(811-813)GGG>GTG	p.G271V	NFKBID_uc002och.1_Missense_Mutation_p.G108V|NFKBID_uc002ocj.1_Missense_Mutation_p.G286V	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	271	ANK 6.				inflammatory response	nucleus					0						GGGGTCCGCCCCAGCTGCCAA	0.692			NA											11	38					0.00010058	0.000118315	0.013537	1	0
ZFP30	22835	broad.mit.edu	37	19	38126043	38126043	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:38126043C>A	uc002ogv.1	-	6	1915	c.1399G>T	c.(1399-1401)GAC>TAC	p.D467Y	ZFP30_uc002ogw.1_Missense_Mutation_p.D467Y|ZFP30_uc002ogx.1_Missense_Mutation_p.D467Y|ZFP30_uc010xtt.1_Missense_Mutation_p.D466Y	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	467	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCTTACAGTCATAGGGCTTT	0.373			NA											15	74					4.7546e-09	6.67289e-09	0.004007	1	0
CATSPERG	57828	broad.mit.edu	37	19	38858712	38858712	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:38858712G>T	uc002oih.3	+	26	3042	c.2955G>T	c.(2953-2955)ACG>ACT	p.T985T	CATSPERG_uc002oig.3_Silent_p.T945T|CATSPERG_uc002oif.3_Silent_p.T625T|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	985	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TCTGGACCACGAGGACCACAA	0.612			NA											27	51					3.80469e-20	6.78713e-20	0.009535	1	0
ITPKC	80271	broad.mit.edu	37	19	41235228	41235228	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:41235228G>T	uc002oot.2	+	3	1410	c.1377G>T	c.(1375-1377)ATG>ATT	p.M459I		NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	459						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ACTATGGCATGGTGCTGCAGG	0.572			NA											10	22					0.00621372	0.00669487	0.006214	1	0
GRIK5	2901	broad.mit.edu	37	19	42563598	42563598	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:42563598C>T	uc002osj.1	-	5	625	c.590G>A	c.(589-591)CGG>CAG	p.R197Q	GRIK5_uc010eib.1_Missense_Mutation_p.R116Q	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	197	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TGTGGGGTCCCGGCTGTCGTC	0.607			NA											26	57					0	0	0.008361	0	0
ZNF526	116115	broad.mit.edu	37	19	42728897	42728897	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:42728897C>G	uc002osz.1	+	3	498	c.342C>G	c.(340-342)AGC>AGG	p.S114R		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	114	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GTGAATGCAGCCAGCTCATCC	0.627			NA											8	49					0	0	0.00308	0	0
C19orf61	56006	broad.mit.edu	37	19	44251914	44251914	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:44251914C>A	uc002oxj.2	-	4	704	c.361G>T	c.(361-363)GGC>TGC	p.G121C	C19orf61_uc002oxk.2_Missense_Mutation_p.G121C|C19orf61_uc010eiy.1_Missense_Mutation_p.G121C	NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	121	Pro-rich.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				GGGGCGGTGCCCTCAGGGGTA	0.682			NA											9	28					0.000274275	0.000313549	0.004482	1	0
HIF3A	64344	broad.mit.edu	37	19	46825041	46825041	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:46825041G>T	uc002peh.2	+	10	1182	c.1153G>T	c.(1153-1155)GGC>TGC	p.G385C	HIF3A_uc002peg.3_Missense_Mutation_p.G385C|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.G329C|HIF3A_uc002pej.1_Missense_Mutation_p.G316C|HIF3A_uc002pek.2_Missense_Mutation_p.G329C|HIF3A_uc010xxy.1_Missense_Mutation_p.G316C|HIF3A_uc002pel.2_Missense_Mutation_p.G383C|HIF3A_uc010xxz.1_Missense_Mutation_p.G334C	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		AGACACCCCTGGCCCCCGGAT	0.672			NA											25	68					2.41591e-17	4.11381e-17	0.004656	1	0
PTGIR	5739	broad.mit.edu	37	19	47127082	47127082	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:47127082C>A	uc002pex.2	-	2	514	c.401G>T	c.(400-402)CGC>CTC	p.R134L		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	134	Cytoplasmic (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GCGGGCGCAGCGGGGCCCGTC	0.701			NA											7	5					0.00621372	0.00669487	0.006214	1	0
PLA2G4C	8605	broad.mit.edu	37	19	48608688	48608688	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:48608688T>A	uc002phx.2	-	3	420	c.22A>T	c.(22-24)ATA>TTA	p.I8L	PLA2G4C_uc002phw.2_5'UTR|PLA2G4C_uc010elr.2_Missense_Mutation_p.I8L|PLA2G4C_uc010xzd.1_Intron|PLA2G4C_uc002phy.3_Missense_Mutation_p.I8L	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	8	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CCAGGAATTATGGAAACTTCA	0.458			NA											17	88					0	0	0.007413	0	0
HRC	3270	broad.mit.edu	37	19	49657099	49657099	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:49657099G>A	uc002pmv.2	-	1	1583	c.1396C>T	c.(1396-1398)CCA>TCA	p.P466S		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	466					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GTGTGTCCTGGGGGGTGATGG	0.547	Melanoma(37;75 1097 24567 25669 30645)		NA											36	109					0	0	0.005524	0	0
SLC6A16	28968	broad.mit.edu	37	19	49797775	49797775	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:49797775C>A	uc002pmz.2	-	8	1499	c.1265G>T	c.(1264-1266)GGG>GTG	p.G422V	SLC6A16_uc002pna.2_Missense_Mutation_p.G422V	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	422	Extracellular (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		AGGCAGTTTCCCTAGGTTTAT	0.488			NA											35	63					2.95478e-19	5.21368e-19	0.00874	1	0
ZNF578	147660	broad.mit.edu	37	19	53007907	53007907	+	Splice_Site	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:53007907G>T	uc002pzp.3	+	5	308	c.64_splice	c.e5-1	p.G22_splice		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TTTCATTTTAGGGACGCTTGA	0.398			NA											35	122					1.30998e-17	2.23846e-17	0.005524	1	0
FCAR	2204	broad.mit.edu	37	19	55401176	55401176	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:55401176C>A	uc002qhr.1	+	5	1008	c.811C>A	c.(811-813)CAG>AAG	p.Q271K	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.Q222K|FCAR_uc010esi.1_Missense_Mutation_p.Q148K|FCAR_uc002qhu.1_Missense_Mutation_p.Q175K|FCAR_uc002qhv.1_Missense_Mutation_p.Q249K|FCAR_uc002qhw.1_Missense_Mutation_p.Q259K|FCAR_uc002qhx.1_Missense_Mutation_p.Q163K|FCAR_uc002qhy.1_Missense_Mutation_p.Q237K|FCAR_uc002qhz.1_3'UTR|FCAR_uc002qia.1_Missense_Mutation_p.Q162K	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	271	Cytoplasmic (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CTGGAGCCAACAGATGTGTCA	0.552			NA											44	120					2.47872e-24	4.58988e-24	0.010771	1	0
FIZ1	84922	broad.mit.edu	37	19	56104097	56104097	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:56104097G>A	uc002qli.3	-	3	1300	c.1210C>T	c.(1210-1212)CCG>TCG	p.P404S	FIZ1_uc002qlj.3_Missense_Mutation_p.P404S	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		GAGCCAGACGGGGGTTCCCCG	0.731			NA											13	22					0	0	0.006122	0	0
U2AF2	11338	broad.mit.edu	37	19	56172460	56172460	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:56172460G>T	uc002qlu.2	+	5	1446	c.391G>T	c.(391-393)GCT>TCT	p.A131S	U2AF2_uc002qlt.2_Missense_Mutation_p.A131S	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	131					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TGACGGTCTGGCTGTGACCCC	0.592			NA											13	40					2.48551e-13	3.9428e-13	0.00499	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701551	56701551	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:56701551G>T	uc010ygh.1	-	4	1133	c.1133C>A	c.(1132-1134)ACA>AAA	p.T378K		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	378					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCTGTCTCCTGTGTGTGACCT	0.537			NA											11	32					6.40141e-05	7.65967e-05	0.010729	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701905	56701905	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:56701905C>A	uc010ygh.1	-	4	779	c.779G>T	c.(778-780)AGA>ATA	p.R260I		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	260					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CACAGAGGCTCTTTTCTGGGG	0.493			NA											13	111					9.31168e-06	1.16277e-05	0.001855	1	0
USP29	57663	broad.mit.edu	37	19	57642636	57642636	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:57642636T>A	uc002qny.2	+	4	2949	c.2593T>A	c.(2593-2595)TCA>ACA	p.S865T		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	865					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCAGAAATCTCAGAGACCAA	0.443			NA											14	39					0	0	0.00245	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565342	58565342	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr19:58565342G>T	uc002qrc.1	+	6	1397	c.1150G>T	c.(1150-1152)GTC>TTC	p.V384F		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	384	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V384I(1)		ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCAGTGTAGCGTCTGCGGGAA	0.692			NA											4	7					0.00909568	0.00973538	0.009096	1	0
PXDN	7837	broad.mit.edu	37	2	1653010	1653010	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:1653010T>A	uc002qxa.2	-	17	2606	c.2542A>T	c.(2542-2544)AGC>TGC	p.S848C		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	848					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CACACGTTGCTGCAGTGCTGT	0.657			NA											4	6					0	0	0.001168	0	0
TSSC1	7260	broad.mit.edu	37	2	3200660	3200660	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:3200660C>A	uc002qxj.2	-	6	838	c.645G>T	c.(643-645)CGG>CGT	p.R215R	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	215	WD 2.						protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		ACCTCATGCTCCGGGTGTCCC	0.627	Colon(140;1261 1762 4183 34270 49743)		NA											12	4					0.00136819	0.00153175	0.013537	1	0
C2orf39	92749	broad.mit.edu	37	2	26652528	26652528	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:26652528G>T	uc002rhg.2	+	5	647	c.573G>T	c.(571-573)AAG>AAT	p.K191N	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	191	Potential.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTATGTGAAGGATTTGAAGA	0.438			NA											41	56					2.66277e-13	4.21028e-13	0.006999	1	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48873798	48873798	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:48873798A>G	uc010yol.1	+	5	2613	c.2566A>G	c.(2566-2568)ATT>GTT	p.I856V	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.I903V|GTF2A1L_uc002rws.1_Missense_Mutation_p.I199V|GTF2A1L_uc010yom.1_Missense_Mutation_p.I165V|GTF2A1L_uc002rwt.2_Missense_Mutation_p.I199V	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	856					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GCAACCCGCAATTCTACCTTC	0.403			NA											24	45					0	0	0.004656	0	0
NAT8B	51471	broad.mit.edu	37	2	73928033	73928033	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:73928033C>A	uc002sjk.1	-	2	435	c.400G>T	c.(400-402)GAG>TAG	p.E134*		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	134	N-acetyltransferase.				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						AACCGCTTCTCCCTCAAGGTG	0.567			NA											12	62					4.3838e-07	5.86514e-07	0.001855	1	0
NAT8B	51471	broad.mit.edu	37	2	73928243	73928243	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:73928243G>T	uc002sjk.1	-	2	225	c.190C>A	c.(190-192)CTC>ATC	p.L64I		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	64	N-acetyltransferase.				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						CTGAACACGAGGGCCAGAATC	0.567			NA											13	46					9.05144e-12	1.39495e-11	0.001855	1	0
TRIM43	129868	broad.mit.edu	37	2	96260875	96260875	+	Silent	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:96260875A>G	uc002suv.2	+	3	625	c.489A>G	c.(487-489)AGA>AGG	p.R163R		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	163						intracellular	zinc ion binding			ovary(1)	1						AGGAGGGAAGAACAGCCTTCC	0.393			NA											6	29					0	0	0.00308	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98195478	98195478	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:98195478C>T	uc010yvc.1	-	5	866	c.586G>A	c.(586-588)GGA>AGA	p.G196R	ANKRD36B_uc010yve.1_RNA|ANKRD36B_uc010fif.2_Intron	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B	196	ANK 6.										0						TCTTTTTCTCCAAGAGTAACA	0.333			NA											4	30					0	0	0.009096	0	0
VWA3B	200403	broad.mit.edu	37	2	98887214	98887214	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:98887214G>T	uc002syo.2	+	22	3177	c.2913G>T	c.(2911-2913)TTG>TTT	p.L971F	VWA3B_uc002sym.2_Missense_Mutation_p.L971F|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.L628F|VWA3B_uc002syp.1_Missense_Mutation_p.L363F|VWA3B_uc002syq.1_Missense_Mutation_p.L247F|VWA3B_uc002syr.1_Missense_Mutation_p.L288F|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	971										ovary(3)|large_intestine(2)|skin(1)	6						TAGAACGGTTGAATTGGCCCA	0.378			NA											65	138					1.07363e-35	2.03447e-35	0.01441	1	0
CNGA3	1261	broad.mit.edu	37	2	99012551	99012551	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:99012551G>C	uc002syt.2	+	8	1335	c.918G>C	c.(916-918)TTG>TTC	p.L306F	CNGA3_uc002syu.2_Missense_Mutation_p.L288F|CNGA3_uc010fij.2_Missense_Mutation_p.L310F	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	306	Helical; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TTGGGAACTTGGTCTTGTACA	0.463			NA											11	61					0	0	0.008291	0	0
INPP4A	3631	broad.mit.edu	37	2	99185059	99185059	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:99185059G>T	uc002syy.2	+	23	2854	c.2461G>T	c.(2461-2463)GTC>TTC	p.V821F	INPP4A_uc010yvj.1_Missense_Mutation_p.V782F|INPP4A_uc010yvk.1_Missense_Mutation_p.V782F|INPP4A_uc002syx.2_Missense_Mutation_p.V816F|INPP4A_uc010fik.2_Missense_Mutation_p.V150F	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	821					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						TTTACAAGAAGTCATCAACGT	0.418			NA											5	12					5.9392e-07	7.90271e-07	0.001168	1	0
MERTK	10461	broad.mit.edu	37	2	112755053	112755053	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:112755053G>T	uc002thk.1	+	10	1726	c.1604G>T	c.(1603-1605)GGG>GTG	p.G535V	MERTK_uc002thl.1_Missense_Mutation_p.G359V	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	535	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						ACAAAGTTTGGGTAAGTCTCC	0.423			NA											19	32					2.54575e-18	4.45964e-18	0.010504	1	0
POLR1B	84172	broad.mit.edu	37	2	113316941	113316941	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:113316941C>T	uc002thw.2	+	9	1982	c.1402C>T	c.(1402-1404)CAT>TAT	p.H468Y	POLR1B_uc010fkn.2_Missense_Mutation_p.H412Y|POLR1B_uc002thx.2_Missense_Mutation_p.H329Y|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.H506Y|POLR1B_uc002thy.2_Missense_Mutation_p.H329Y|POLR1B_uc010yxo.1_Missense_Mutation_p.H245Y	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	468					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						CTACCTCTCCCATTTCCGCTG	0.502	Ovarian(16;256 576 9537 23969 41147)		NA											67	183					0	0	0.01441	0	0
EN1	2019	broad.mit.edu	37	2	119604045	119604045	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:119604045C>T	uc002tlm.2	-	1	1715	c.699G>A	c.(697-699)GGG>GGA	p.G233G		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	233					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						CTCCGGGGCTCCCCGCGCCGC	0.507			NA											3	8					0	0	0.004672	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125204514	125204514	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:125204514G>T	uc002tno.2	+	6	1282	c.918G>T	c.(916-918)GAG>GAT	p.E306D	CNTNAP5_uc010flu.2_Missense_Mutation_p.E306D	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	306	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTGACTATGAGGTGAGTTGAT	0.547			NA											18	29					5.3912e-06	6.81952e-06	0.006122	1	0
CFC1B	653275	broad.mit.edu	37	2	131356256	131356256	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:131356256C>A	uc002tro.1	-	3	597	c.206G>T	c.(205-207)GGG>GTG	p.G69V		NM_001079530	NP_001072998	P0CG36	CFC1B_HUMAN	cripto, FRL-1, cryptic family 1B	69					gastrulation	extracellular region					0	Colorectal(110;0.1)					CTCCTCCGGCCCCCAGCCCTC	0.627			NA											18	75					7.53681e-25	1.4117e-24	0.00632	1	0
GPR148	344561	broad.mit.edu	37	2	131486929	131486929	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:131486929C>A	uc002trv.1	+	1	207	c.205C>A	c.(205-207)CTG>ATG	p.L69M		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	69	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					TGTCAGCCCCCTGCTGCTGGT	0.627			NA											12	30					3.07112e-06	3.92555e-06	0.010729	1	0
LYPD6	130574	broad.mit.edu	37	2	150327362	150327362	+	Nonstop_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:150327362T>C	uc002twy.2	+	5	709	c.514T>C	c.(514-516)TAG>CAG	p.*172Q	LYPD6_uc010fnt.2_RNA|LYPD6_uc002twz.2_RNA|LYPD6_uc002txa.2_Nonstop_Mutation_p.*172Q	NM_194317	NP_919298	Q86Y78	LYPD6_HUMAN	LY6/PLAUR domain containing 6 precursor	172						extracellular region					0				BRCA - Breast invasive adenocarcinoma(221;0.0667)		GCTCATGTTATAGTGGCTCAG	0.488			NA											26	71					0	0	0.00632	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711698	155711698	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:155711698C>A	uc002tyv.1	+	3	1574	c.1379C>A	c.(1378-1380)TCT>TAT	p.S460Y	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	460	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AAGATGTTATCTGATCCCATG	0.468			NA											21	50					4.96729e-08	6.83353e-08	0.008871	1	0
CCDC148	130940	broad.mit.edu	37	2	159195539	159195539	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:159195539T>C	uc002tzq.2	-	6	808	c.545A>G	c.(544-546)CAG>CGG	p.Q182R	CCDC148_uc002tzr.2_Missense_Mutation_p.Q30R|CCDC148_uc010foh.2_Intron|CCDC148_uc010foi.1_Missense_Mutation_p.Q129R|CCDC148_uc010foj.1_Missense_Mutation_p.Q30R|CCDC148_uc010fok.1_Missense_Mutation_p.Q96R|CCDC148_uc002tzs.1_Missense_Mutation_p.Q182R	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	182	Potential.									ovary(2)	2						TTCTATTCTCTGTTGCTCCAG	0.313			NA											31	70					0	0	0.003271	0	0
SCN3A	6328	broad.mit.edu	37	2	165970389	165970389	+	Silent	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:165970389A>G	uc002ucx.2	-	20	4098	c.3606T>C	c.(3604-3606)ATT>ATC	p.I1202I	SCN3A_uc002ucy.2_Silent_p.I1153I|SCN3A_uc002ucz.2_Silent_p.I1153I|SCN3A_uc002uda.1_Silent_p.I1022I|SCN3A_uc002udb.1_Silent_p.I1022I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1202	Helical; Name=S1 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TGTGCTCAACAATACTGTAGC	0.378			NA											43	95					0	0	0.013114	0	0
SCN1A	6323	broad.mit.edu	37	2	166898802	166898802	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:166898802C>A	uc010zcz.1	-	12	2161	c.2143G>T	c.(2143-2145)GAA>TAA	p.E715*	SCN1A_uc002udo.3_Nonsense_Mutation_p.E595*|SCN1A_uc010fpk.2_Nonsense_Mutation_p.E567*	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	726						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGTTACCAACCTTCTACTGTA	0.343			NA											32	81					2.08457e-15	3.4413e-15	0.010818	1	0
LRP2	4036	broad.mit.edu	37	2	170145561	170145561	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:170145561G>T	uc002ues.2	-	9	1230	c.1017C>A	c.(1015-1017)AAC>AAA	p.N339K	LRP2_uc010zdf.1_Missense_Mutation_p.N339K	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	339	EGF-like 1.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGTCATTGTGGTTGATGATAT	0.512			NA											19	60					6.33239e-15	1.03486e-14	0.010504	1	0
WIPF1	7456	broad.mit.edu	37	2	175436881	175436881	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:175436881T>A	uc002uiy.2	-	6	984	c.652A>T	c.(652-654)ACT>TCT	p.T218S	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.T218S|WIPF1_uc010fqt.1_Missense_Mutation_p.T218S|WIPF1_uc002ujc.1_Missense_Mutation_p.T218S|WIPF1_uc002uiz.2_Missense_Mutation_p.T218S|WIPF1_uc002ujb.1_Missense_Mutation_p.T218S|WIPF1_uc010zep.1_Missense_Mutation_p.T218S	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	218					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GGGGGAGGAGTGGGCCCGGGG	0.652			NA											21	42					0	0	0.010504	0	0
EVX2	344191	broad.mit.edu	37	2	176948097	176948097	+	Silent	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:176948097A>T	uc010zeu.1	-	1	594	c.408T>A	c.(406-408)CTT>CTA	p.L136L		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	136						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		TGTTTTCCTTAAGCTGAGCGG	0.687			NA											8	7					0	0	0.00308	0	0
TTN	7273	broad.mit.edu	37	2	179458826	179458826	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:179458826G>T	uc010zfg.1	-	246	50814	c.50590C>A	c.(50590-50592)CGC>AGC	p.R16864S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R10559S|TTN_uc010zfi.1_Missense_Mutation_p.R10492S|TTN_uc010zfj.1_Missense_Mutation_p.R10367S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17791							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATGAGTGCGATCATCTTCC	0.463			NA											25	74					8.24728e-16	1.36613e-15	0.004656	1	0
TTN	7273	broad.mit.edu	37	2	179466637	179466637	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:179466637C>T	uc010zfg.1	-	234	47794	c.47570G>A	c.(47569-47571)GGA>GAA	p.G15857E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G9552E|TTN_uc010zfi.1_Missense_Mutation_p.G9485E|TTN_uc010zfj.1_Missense_Mutation_p.G9360E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16784							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCATGAACTCCATCCTATTA	0.313			NA											9	52					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179614227	179614227	+	Silent	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:179614227T>C	uc002unb.2	-	46	13124	c.12900A>G	c.(12898-12900)GTA>GTG	p.V4300V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	433							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATATTCTTTTACATTTGTCC	0.398			NA											26	72					0	0	0.003954	0	0
COL3A1	1281	broad.mit.edu	37	2	189868727	189868727	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:189868727G>C	uc002uqj.1	+	39	2798	c.2681G>C	c.(2680-2682)GGT>GCT	p.G894A		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	894	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGACCCCCAGGTCCCAGCGGT	0.453			NA											7	15					0	0	0.00308	0	0
COL3A1	1281	broad.mit.edu	37	2	189876399	189876399	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:189876399C>A	uc002uqj.1	+	51	4417	c.4300C>A	c.(4300-4302)CGC>AGC	p.R1434S		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1434	Fibrillar collagen NC1.		R -> C (in a colorectal cancer sample; somatic mutation).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.R1434C(1)		central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ATATCGAACACGCAAGGCTGT	0.393			NA											27	70					4.87955e-14	7.86869e-14	0.005443	1	0
FZD7	8324	broad.mit.edu	37	2	202899689	202899689	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:202899689G>T	uc002uyw.1	+	1	380	c.319G>T	c.(319-321)GCG>TCG	p.A107S		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	107	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						CTCCATGTATGCGCCCGTGTG	0.622			NA									OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	53					1.99824e-07	2.70317e-07	0.00499	1	0
ABI2	10152	broad.mit.edu	37	2	204259513	204259513	+	Silent	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:204259513C>G	uc002vaa.2	+	6	904	c.669C>G	c.(667-669)CCC>CCG	p.P223P	ABI2_uc010zig.1_Intron|ABI2_uc002uzz.2_Silent_p.P217P|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Silent_p.P217P|ABI2_uc010zij.1_Silent_p.P161P|ABI2_uc002vab.2_Silent_p.P172P|ABI2_uc010zik.1_Intron|ABI2_uc010zil.1_Silent_p.P58P|ABI2_uc010zim.1_Intron|ABI2_uc002vac.2_Intron|ABI2_uc010zin.1_5'UTR	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	223	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						ATATGGCTCCCTCGCAGCAGA	0.498			NA											41	112					0	0	0.00874	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209165672	209165672	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:209165672G>C	uc002vcz.2	+	9	1220	c.1062G>C	c.(1060-1062)CAG>CAC	p.Q354H	PIKFYVE_uc010fun.1_Missense_Mutation_p.Q35H|PIKFYVE_uc002vcy.1_Missense_Mutation_p.Q354H|PIKFYVE_uc002vcv.2_Missense_Mutation_p.Q257H|PIKFYVE_uc002vcw.2_Missense_Mutation_p.Q354H|PIKFYVE_uc002vcx.2_Missense_Mutation_p.Q268H	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	354					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						ACAGTGTGCAGTTAAAAGACC	0.403			NA											11	91					0	0	0.00245	0	0
ALPPL2	251	broad.mit.edu	37	2	233274340	233274340	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:233274340G>A	uc002vss.3	+	11	1410	c.1357G>A	c.(1357-1359)GGC>AGC	p.G453S		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	453					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GACCCACGCAGGCGAGGACGT	0.657			NA											3	13					0	0	0.004672	0	0
CHRND	1144	broad.mit.edu	37	2	233391241	233391241	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr2:233391241A>T	uc002vsw.2	+	2	59	c.55A>T	c.(55-57)AGC>TGC	p.S19C	CHRND_uc010zmg.1_Missense_Mutation_p.S19C|CHRND_uc010fyc.2_5'UTR|CHRND_uc010zmh.1_5'UTR	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	19					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CTCCCCAGGCAGCTGGGGGCT	0.622			NA											10	62					0	0	0.013537	0	0
TRIB3	57761	broad.mit.edu	37	20	368840	368840	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr20:368840G>A	uc002wdm.2	+	2	692	c.186G>A	c.(184-186)GTG>GTA	p.V62V	TRIB3_uc002wdn.2_Silent_p.V89V	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	62					apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CAACTGCTGTGGCCACTGCCT	0.667	Melanoma(101;421 2374 19538)		NA											21	67					0	0	0.012319	0	0
TMX4	56255	broad.mit.edu	37	20	7963092	7963092	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr20:7963092C>A	uc002wmx.1	-	8	989	c.856G>T	c.(856-858)GCT>TCT	p.A286S		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	286	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane					0						ACACCAGCAGCCAAGTTGtcc	0.323			NA											10	43					0.000442599	0.000500106	0.006214	1	0
ZNF831	128611	broad.mit.edu	37	20	57768085	57768085	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr20:57768085G>C	uc002yan.2	+	1	2011	c.2011G>C	c.(2011-2013)GTC>CTC	p.V671L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	671						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CTCAGGCACAGTCCCCACCCA	0.622			NA											6	11					0	0	0.001168	0	0
ZNF831	128611	broad.mit.edu	37	20	57829482	57829482	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr20:57829482G>T	uc002yan.2	+	5	4718	c.4718G>T	c.(4717-4719)GGA>GTA	p.G1573V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1573						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCAGCTTCAGGACCAAGTTCA	0.493			NA											11	53					0.000673444	0.00075743	0.008291	1	0
TAF4	6874	broad.mit.edu	37	20	60584201	60584201	+	Silent	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr20:60584201T>C	uc002ybs.2	-	5	1791	c.1791A>G	c.(1789-1791)AAA>AAG	p.K597K		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	597	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			ATAGGAAATTTTTACATTTCT	0.353			NA											23	39					0	0	0.014323	0	0
ZGPAT	84619	broad.mit.edu	37	20	62340383	62340383	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr20:62340383A>G	uc002ygk.2	+	2	629	c.451A>G	c.(451-453)ATG>GTG	p.M151V	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Missense_Mutation_p.M151V|ZGPAT_uc002ygj.2_Missense_Mutation_p.M151V|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Missense_Mutation_p.M151V|ZGPAT_uc002ygm.2_Missense_Mutation_p.M151V|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	151					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					TCACAACGCCATGGTGGTGGG	0.512			NA											28	74					0	0	0.010818	0	0
TPTE	7179	broad.mit.edu	37	21	10944750	10944750	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr21:10944750C>A	uc002yip.1	-	11	852	c.484G>T	c.(484-486)GAT>TAT	p.D162Y	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D144Y|TPTE_uc002yir.1_Missense_Mutation_p.D124Y|TPTE_uc010gkv.1_Missense_Mutation_p.D24Y	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	162					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGGCAGTATCTAAAATGTTA	0.308			NA											9	109					1.33987e-11	2.04551e-11	0.008291	1	0
C21orf91	54149	broad.mit.edu	37	21	19165870	19165870	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr21:19165870C>T	uc002yko.3	-	5	847	c.756G>A	c.(754-756)GTG>GTA	p.V252V	C21orf91_uc002ykm.2_5'Flank|C21orf91_uc002ykn.2_5'Flank|C21orf91_uc002ykq.3_Silent_p.V251V|C21orf91_uc002ykp.3_3'UTR	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	252										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		CTTTTTCTTGCACTTGGTGAG	0.393			NA											4	28					0	0	0.000602	0	0
NCAM2	4685	broad.mit.edu	37	21	22849786	22849786	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr21:22849786A>G	uc002yld.1	+	15	2320	c.2071A>G	c.(2071-2073)ATT>GTT	p.I691V	NCAM2_uc011acb.1_Missense_Mutation_p.I549V	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	691	Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GCCCAACATTATTAAAGGTAA	0.333			NA											13	55					0	0	0.00245	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744439	31744439	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr21:31744439G>T	uc002ynz.3	-	1	119	c.93C>A	c.(91-93)CCC>CCA	p.P31P		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	31						intermediate filament					0						CCAGATTGCTGGGGTAGGAAA	0.582			NA											24	49					3.5997e-14	5.84351e-14	0.014323	1	0
MYO18B	84700	broad.mit.edu	37	22	26194047	26194047	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr22:26194047C>A	uc003abz.1	+	12	2754	c.2504C>A	c.(2503-2505)GCG>GAG	p.A835E	MYO18B_uc003aca.1_Missense_Mutation_p.A716E|MYO18B_uc010guy.1_Missense_Mutation_p.A716E|MYO18B_uc010guz.1_Missense_Mutation_p.A716E|MYO18B_uc011aka.1_Intron|MYO18B_uc011akb.1_Missense_Mutation_p.A348E	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	835	Myosin head-like.		A -> G (in a lung squamous cell carcinoma sample; somatic mutation).			nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CACCTGGGTGCGGCGGGGGCC	0.662			NA											8	27					9.70103e-10	1.41449e-09	0.008291	1	0
INPP5J	27124	broad.mit.edu	37	22	31522949	31522949	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr22:31522949G>A	uc003aju.3	+	5	1629	c.1537G>A	c.(1537-1539)GCC>ACC	p.A513T	INPP5J_uc010gwf.2_Missense_Mutation_p.A513T|INPP5J_uc003ajv.3_Missense_Mutation_p.A146T|INPP5J_uc003ajs.3_Missense_Mutation_p.A146T|INPP5J_uc011alk.1_Missense_Mutation_p.A446T|INPP5J_uc010gwg.2_Missense_Mutation_p.A78T|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.A145T|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	513	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						GCTGCTGTTCGCCAAGTACTA	0.662			NA											4	7					0	0	0.009096	0	0
MEI1	150365	broad.mit.edu	37	22	42174740	42174740	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr22:42174740C>G	uc003baz.1	+	22	2764	c.2739C>G	c.(2737-2739)AGC>AGG	p.S913R	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.S299R|MEI1_uc003bbc.1_Missense_Mutation_p.S281R|MEI1_uc010gym.1_Intron|MEI1_uc003bbd.1_Missense_Mutation_p.S156R|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA|MEI1_uc011apf.1_5'Flank|MEI1_uc010gyo.1_5'Flank|MEI1_uc003bbf.2_5'Flank|MEI1_uc003bbg.2_5'Flank	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	913							binding			central_nervous_system(1)|skin(1)	2						TGCTGCTGAGCCTCCTCTCCC	0.577			NA											3	9					0	0	0.004672	0	0
PPARA	5465	broad.mit.edu	37	22	46615710	46615710	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr22:46615710G>A	uc003bgw.1	+	7	776	c.510G>A	c.(508-510)GCG>GCA	p.A170A	PPARA_uc003bgx.1_Silent_p.A170A|PPARA_uc010hab.1_Silent_p.A170A|PPARA_uc003bha.2_Silent_p.A170A|PPARA_uc003bhb.1_Silent_p.A170A|PPARA_uc010hac.1_Intron	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	170	Nuclear receptor.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	AAACCCTAGCGATTCGTTTTG	0.493			NA											8	53					0	0	0.006214	0	0
MOV10L1	54456	broad.mit.edu	37	22	50572451	50572451	+	Silent	SNP	G	G	T	rs148444495		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr22:50572451G>T	uc003bjj.2	+	14	2009	c.1926G>T	c.(1924-1926)CGG>CGT	p.R642R	MOV10L1_uc003bjk.3_Silent_p.R642R|MOV10L1_uc011arp.1_Silent_p.R622R|MOV10L1_uc011arq.1_Silent_p.R403R|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	642					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CAAGCAGACGGTGTCACTTTG	0.343			NA											9	57					7.48243e-07	9.87518e-07	0.006214	1	0
GRIP2	80852	broad.mit.edu	37	3	14552931	14552931	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr3:14552931C>A	uc011avi.1	-	16	2071	c.2071G>T	c.(2071-2073)GTG>TTG	p.V691L	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Missense_Mutation_p.V222L	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	593	PDZ 5.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						CTGTGTGCCACGCTGCCTTTC	0.602			NA											11	27					0.000151284	0.00017668	0.001855	1	0
TTC21A	199223	broad.mit.edu	37	3	39174562	39174562	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr3:39174562G>T	uc003cjc.2	+	20	2780	c.2603G>T	c.(2602-2604)CGG>CTG	p.R868L	TTC21A_uc003cje.2_Missense_Mutation_p.R869L|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.R820L|TTC21A_uc011ayy.1_5'UTR|TTC21A_uc003cjf.2_5'UTR	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	868	TPR 12.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CTCCAGTCTCGGATACTGAAG	0.488			NA											8	31					0.000274275	0.000313549	0.004482	1	0
ZBTB38	253461	broad.mit.edu	37	3	141163939	141163939	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr3:141163939C>T	uc003etw.2	+	8	3691	c.2709C>T	c.(2707-2709)TTC>TTT	p.F903F	ZBTB38_uc010hun.2_Silent_p.F900F|ZBTB38_uc010huo.2_Silent_p.F903F|ZBTB38_uc003ety.2_Silent_p.F903F|ZBTB38_uc010hup.2_Silent_p.F904F	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	903					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTGAAGTGTTCGATGACGCAA	0.507			NA											3	16					0	0	0.004672	0	0
WDR49	151790	broad.mit.edu	37	3	167246862	167246862	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr3:167246862C>A	uc003fev.1	-	10	1634	c.1328G>T	c.(1327-1329)TGG>TTG	p.W443L	WDR49_uc003feu.1_Missense_Mutation_p.W268L|WDR49_uc011bpd.1_Missense_Mutation_p.W507L|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	443	WD 7.									large_intestine(1)|ovary(1)|skin(1)	3						GATTTTCAACCATCCATCAAG	0.358			NA											14	32					0.000151284	0.00017668	0.001855	1	0
SAMD7	344658	broad.mit.edu	37	3	169646344	169646344	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr3:169646344C>T	uc003fgd.2	+	7	1286	c.1019C>T	c.(1018-1020)CCA>CTA	p.P340L	SAMD7_uc003fge.2_Missense_Mutation_p.P340L|SAMD7_uc011bpo.1_Missense_Mutation_p.P241L	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	340	SAM.									skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			CGCAGCCTTCCAGGTTGTTCA	0.398			NA											45	85					0	0	0.01441	0	0
PCDH7	5099	broad.mit.edu	37	4	30724495	30724495	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:30724495A>C	uc003gsk.1	+	1	2459	c.1451A>C	c.(1450-1452)AAG>ACG	p.K484T	PCDH7_uc011bxw.1_Missense_Mutation_p.K437T|PCDH7_uc011bxx.1_Missense_Mutation_p.K484T	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	484	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AACAAGAAAAAGTACTTCTTG	0.632			NA											3	9					0	0	0.009096	0	0
SRD5A3	79644	broad.mit.edu	37	4	56212671	56212671	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:56212671G>A	uc003hau.2	+	1	263	c.168G>A	c.(166-168)AAG>AAA	p.K56K		NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	56	Lumenal (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GGAAAACCAAGTGTGGGGAGC	0.697			NA											3	8					0	0	0.004672	0	0
CCDC158	339965	broad.mit.edu	37	4	77288728	77288728	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:77288728C>A	uc003hkb.3	-	11	1702	c.1549G>T	c.(1549-1551)GCA>TCA	p.A517S		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	517	Potential.									skin(3)|ovary(2)|pancreas(1)	6						GTGATCTCTGCATTGGTAGCC	0.483			NA											10	49					0.000442599	0.000500106	0.006214	1	0
PKD2	5311	broad.mit.edu	37	4	88959554	88959554	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:88959554C>G	uc003hre.2	+	4	1061	c.995C>G	c.(994-996)TCT>TGT	p.S332C		NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	332	Extracellular (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		GGATCCTGCTCTATCCCCCAG	0.488			NA											18	27					0	0	0.007413	0	0
SCLT1	132320	broad.mit.edu	37	4	129867262	129867262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:129867262C>A	uc003igp.2	-	16	1845	c.1339G>T	c.(1339-1341)GAA>TAA	p.E447*	SCLT1_uc003ign.2_Nonsense_Mutation_p.E111*|SCLT1_uc003igo.2_Nonsense_Mutation_p.E57*|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	447	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						TGCATTTCTTCCAGTTTTCTG	0.348			NA											15	21					1.05317e-09	1.53103e-09	0.00245	1	0
RBM46	166863	broad.mit.edu	37	4	155720237	155720237	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:155720237C>T	uc003ioo.2	+	4	1096	c.923C>T	c.(922-924)CCA>CTA	p.P308L	RBM46_uc011cim.1_Missense_Mutation_p.P308L|RBM46_uc003iop.1_Missense_Mutation_p.P308L	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	308	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				CTAGCTAAACCAGTAAATAAA	0.383			NA											12	26					0	0	0.010729	0	0
NEK1	4750	broad.mit.edu	37	4	170384541	170384541	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:170384541T>A	uc003isb.1	-	25	2848	c.2356A>T	c.(2356-2358)ACA>TCA	p.T786S	NEK1_uc003isc.1_Missense_Mutation_p.T742S|NEK1_uc003isd.1_Missense_Mutation_p.T814S|NEK1_uc003ise.1_Missense_Mutation_p.T770S|NEK1_uc003isf.1_Missense_Mutation_p.T717S	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	786					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCTCCCACTGTATGTCCTATA	0.353			NA											28	30					0	0	0.009535	0	0
SLC6A19	340024	broad.mit.edu	37	5	1201769	1201769	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:1201769G>T	uc003jbw.3	+	1	60	c.4G>T	c.(4-6)GTG>TTG	p.V2L		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	2	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GACCACCATGGTGAGGCTCGT	0.682			NA											3	13					2.56e-06	3.28084e-06	0.009096	1	0
TRIO	7204	broad.mit.edu	37	5	14507306	14507306	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:14507306G>T	uc003jff.2	+	56	8694	c.8688G>T	c.(8686-8688)CTG>CTT	p.L2896L	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2896	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GGGCGCACCTGGGGGAGGTTC	0.632			NA											10	23					2.80697e-09	3.96231e-09	0.010729	1	0
DAB2	1601	broad.mit.edu	37	5	39390615	39390615	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:39390615G>A	uc003jlx.2	-	5	924	c.393C>T	c.(391-393)AAC>AAT	p.N131N	DAB2_uc003jlw.2_Silent_p.N131N	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	131	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CAAATGCCCGGTTGTCTGTCA	0.408			NA											23	60					0	0	0.00333	0	0
GHR	2690	broad.mit.edu	37	5	42718832	42718832	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:42718832C>T	uc003jmt.2	+	10	1266	c.1223C>T	c.(1222-1224)ACC>ATC	p.T408I	GHR_uc011cpq.1_Missense_Mutation_p.T221I	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	408	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CATGAGGGTACCTCAGAGGTT	0.468			NA											10	64					0	0	0.013537	0	0
HMGCR	3156	broad.mit.edu	37	5	74652176	74652176	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:74652176G>T	uc003kdp.2	+	15	2045	c.1889G>T	c.(1888-1890)CGT>CTT	p.R630L	HMGCR_uc011cst.1_Missense_Mutation_p.R650L|HMGCR_uc003kdq.2_Missense_Mutation_p.R577L|HMGCR_uc010izo.2_5'Flank|HMGCR_uc010izp.2_5'Flank	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	630	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	AGATTTGCACGTCTACAGAAA	0.284			NA											19	46					1.01871e-10	1.5265e-10	0.008871	1	0
YTHDC2	64848	broad.mit.edu	37	5	112927872	112927872	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:112927872G>T	uc003kqn.2	+	28	4392	c.4209G>T	c.(4207-4209)GGG>GGT	p.G1403G		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1403	YTH.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		GCAGGGATGGGCAGGTATACA	0.353			NA											13	11					2.23348e-06	2.87753e-06	0.004007	1	0
FBN2	2201	broad.mit.edu	37	5	127641204	127641204	+	Silent	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:127641204T>C	uc003kuu.2	-	44	6112	c.5673A>G	c.(5671-5673)GTA>GTG	p.V1891V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1891	EGF-like 30; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTTTCTTACCTACACAGGCCC	0.428			NA											16	27					0	0	0.004007	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175015	140175015	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:140175015G>T	uc003lhd.2	+	1	572	c.466G>T	c.(466-468)GGA>TGA	p.G156*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Nonsense_Mutation_p.G156*|PCDHA2_uc011czy.1_Nonsense_Mutation_p.G156*	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	156	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTCTAGAGGGAGCATCTGA	0.438			NA											29	33					4.59853e-10	6.76581e-10	0.005443	1	0
PCDHB2	56133	broad.mit.edu	37	5	140474663	140474663	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:140474663C>A	uc003lil.2	+	1	427	c.289C>A	c.(289-291)CTG>ATG	p.L97M	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	97	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGAGGAGCTGTGCGGCCC	0.502			NA											14	27					4.14922e-12	6.41482e-12	0.004007	1	0
PCDHB12	56124	broad.mit.edu	37	5	140589646	140589646	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:140589646C>T	uc003liz.2	+	1	1356	c.1167C>T	c.(1165-1167)ATC>ATT	p.I389I	PCDHB12_uc011dak.1_Silent_p.I52I	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	389	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGAGGACATCCCATTCGTGC	0.473			NA											6	20					0	0	0.001168	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589974	140589974	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:140589974C>T	uc003liz.2	+	1	1684	c.1495C>T	c.(1495-1497)CCC>TCC	p.P499S	PCDHB12_uc011dak.1_Missense_Mutation_p.P162S	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	499	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCGCACCTGCCCCTCGCCTC	0.677			NA											14	34					0	0	0.00499	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140753949	140753949	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:140753949C>T	uc003ljy.1	+	1	299	c.299C>T	c.(298-300)CCG>CTG	p.P100L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.P100L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	100	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAGAGCCCGCGGTGTCTG	0.512			NA											14	46					0	0	0.001855	0	0
C5orf58	133874	broad.mit.edu	37	5	169673105	169673105	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:169673105T>A	uc010jjn.2	+	4	380	c.297T>A	c.(295-297)AGT>AGA	p.S99R	C5orf58_uc003mal.2_Intron	NM_001102609	NP_001096079	C9J3I9	CE058_HUMAN	hypothetical protein LOC133874	99											0						TTTCTAACAGTTTTTCTATCT	0.299			NA											6	27					0	0	0.001984	0	0
LCP2	3937	broad.mit.edu	37	5	169680125	169680125	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:169680125C>G	uc003man.1	-	18	1450	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	LCP2_uc011des.1_Missense_Mutation_p.E210Q|LCP2_uc011det.1_Missense_Mutation_p.E244Q	NM_005565	NP_005556	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2	415					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		TCTCTTACCTCTTCCTCCGCG	0.463			NA											3	11					0	0	0.004672	0	0
SLC34A1	6569	broad.mit.edu	37	5	176820729	176820729	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr5:176820729C>A	uc003mgk.3	+	9	1072	c.971C>A	c.(970-972)TCC>TAC	p.S324Y		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	324	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGGCCAACTCCAGCCAGACC	0.537			NA											3	22					2.56e-06	3.28084e-06	0.009096	1	0
RIOK1	83732	broad.mit.edu	37	6	7393347	7393347	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:7393347G>T	uc003mxn.2	+	2	261	c.87G>T	c.(85-87)TTG>TTT	p.L29F	RIOK1_uc003mxm.1_5'UTR	NM_031480	NP_113668	Q9BRS2	RIOK1_HUMAN	RIO kinase 1 isoform 1	29							ATP binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|skin(1)	4	Ovarian(93;0.0418)					ACAGAGACTTGAAGACAGTCA	0.234			NA											14	49					7.93312e-07	1.04417e-06	0.00245	1	0
JARID2	3720	broad.mit.edu	37	6	15496943	15496943	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:15496943G>A	uc003nbj.2	+	7	1731	c.1487G>A	c.(1486-1488)AGG>AAG	p.R496K	JARID2_uc011diu.1_Missense_Mutation_p.R360K|JARID2_uc011div.1_Missense_Mutation_p.R324K|JARID2_uc011diw.1_Missense_Mutation_p.R458K	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	496					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGTCTGGAGAGGAATCGGCCG	0.657			NA											3	29					0	0	0.009096	0	0
CAP2	10486	broad.mit.edu	37	6	17539605	17539605	+	Nonsense_Mutation	SNP	G	G	T	rs147812744		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:17539605G>T	uc003ncb.2	+	8	985	c.742G>T	c.(742-744)GAG>TAG	p.E248*	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Nonsense_Mutation_p.E222*|CAP2_uc011djb.1_Nonsense_Mutation_p.E184*|CAP2_uc011djc.1_Nonsense_Mutation_p.E136*|CAP2_uc011djd.1_Intron	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	248					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TCCACTTTTCGAGAATGAAGG	0.502			NA											27	77					1.2476e-16	2.10965e-16	0.00632	1	0
BTN3A3	10384	broad.mit.edu	37	6	26448954	26448954	+	Splice_Site	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:26448954A>T	uc003nhz.2	+	8	1118	c.938_splice	c.e8-2	p.K313_splice	BTN3A3_uc003nia.2_Splice_Site_p.K271_splice|BTN3A3_uc011dkn.1_Splice_Site_p.E264_splice	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a							integral to membrane					0						ATTCCATTGCAGAGTGGAGGA	0.443			NA											32	101					0	0	0.004289	0	0
OR10C1	442194	broad.mit.edu	37	6	29408195	29408195	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:29408195C>A	uc011dlp.1	+	1	403	c.403C>A	c.(403-405)CTG>ATG	p.L135M	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCACTGCTGCTGAGCCACCG	0.627			NA											9	48					3.09899e-07	4.16908e-07	0.004482	1	0
OR2H1	26716	broad.mit.edu	37	6	29430207	29430207	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:29430207C>T	uc003nmi.2	+	3	1104	c.661C>T	c.(661-663)CAG>TAG	p.Q221*	OR2H1_uc003nmj.1_Nonsense_Mutation_p.Q221*|OR2H1_uc010jri.1_Nonsense_Mutation_p.Q143*	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCCACTGCCCAGGCAGTGCT	0.532			NA											12	97					0	0	0.001855	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:29910607G>C	uc003nol.2	+	2	147	c.147G>C	c.(145-147)GTG>GTC	p.V49V	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Silent_p.V49V|HLA-A_uc003noo.2_Silent_p.V49V|HLA-A_uc010jrr.2_Silent_p.V49V|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Silent_p.V21V|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCATCGCCGTGGGCTACGTGG	0.692			NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			3	18					0	0	0.004672	0	0
GPR115	221393	broad.mit.edu	37	6	47682320	47682320	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:47682320G>T	uc003oza.1	+	6	1597	c.1339G>T	c.(1339-1341)GCA>TCA	p.A447S	GPR115_uc003oyz.1_Missense_Mutation_p.A504S|GPR115_uc003ozb.1_Missense_Mutation_p.A445S	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	447	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CGTGAATATAGCAGTGTCCCT	0.468	GBM(22;431 510 9010 26644 32828)		NA											24	115					1.10923e-09	1.60773e-09	0.00278	1	0
TFAP2D	83741	broad.mit.edu	37	6	50683135	50683135	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:50683135C>A	uc003paf.2	+	2	858	c.346C>A	c.(346-348)CTG>ATG	p.L116M	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	116							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CTTTATTAACCTGCACAATGC	0.637			NA											12	38					2.32078e-09	3.29511e-09	0.003163	1	0
TFAP2D	83741	broad.mit.edu	37	6	50696702	50696702	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:50696702C>T	uc003paf.2	+	4	1244	c.732C>T	c.(730-732)CTC>CTT	p.L244L	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	244							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CTGAGTGCCTCAATGCTTCAC	0.468			NA											6	58					0	0	0.001168	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55406914	55406914	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:55406914G>A	uc003pcn.2	-	3	382	c.223C>T	c.(223-225)CCT>TCT	p.P75S	HMGCLL1_uc003pco.2_Missense_Mutation_p.P45S|HMGCLL1_uc010jzx.2_5'UTR|HMGCLL1_uc011dxc.1_Missense_Mutation_p.P45S|HMGCLL1_uc011dxd.1_Missense_Mutation_p.P45S|HMGCLL1_uc011dxe.1_Missense_Mutation_p.P45S|HMGCLL1_uc003pcp.2_Missense_Mutation_p.P45S	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	75							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACAAACTCAGGGAGTCCAGAT	0.323	Ovarian(35;840 893 7837 15538 42887)		NA											9	25					0	0	0.006214	0	0
COL19A1	1310	broad.mit.edu	37	6	70890390	70890390	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:70890390G>T	uc003pfc.1	+	44	2867	c.2750G>T	c.(2749-2751)GGA>GTA	p.G917V		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	917	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGTTTCCCTGGACCAGAAGGA	0.408			NA											27	60					1.80694e-10	2.69933e-10	0.009535	1	0
MTO1	25821	broad.mit.edu	37	6	74183111	74183111	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:74183111G>T	uc003pgy.3	+	4	683	c.559G>T	c.(559-561)GAG>TAG	p.E187*	MTO1_uc010kav.2_Nonsense_Mutation_p.E187*|MTO1_uc003pgz.3_Nonsense_Mutation_p.E187*|MTO1_uc003pha.3_Intron|MTO1_uc003phb.3_Nonsense_Mutation_p.E113*	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	187					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						AGTATATGCAGAGAGTGTGAT	0.318			NA											22	37					1.42536e-11	2.16246e-11	0.004656	1	0
SENP6	26054	broad.mit.edu	37	6	76405596	76405596	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:76405596C>G	uc003pid.3	+	17	2771	c.2152C>G	c.(2152-2154)CTT>GTT	p.L718V	SENP6_uc003pie.3_Missense_Mutation_p.L711V|SENP6_uc010kbf.2_RNA	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	718	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				CTATAAACGCCTTAATCAGAG	0.318			NA											15	90					0	0	0.004007	0	0
C6orf165	154313	broad.mit.edu	37	6	88123581	88123581	+	Missense_Mutation	SNP	G	G	T	rs140621996		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:88123581G>T	uc003plv.2	+	4	338	c.246G>T	c.(244-246)AAG>AAT	p.K82N	C6orf165_uc003plw.2_5'UTR|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.K82N	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	82										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		ACACTATTAAGATGCAAGTCT	0.333			NA											13	50					7.05477e-17	1.1971e-16	0.00499	1	0
PM20D2	135293	broad.mit.edu	37	6	89871553	89871553	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:89871553A>G	uc003pmz.2	+	6	1195	c.1100A>G	c.(1099-1101)TAT>TGT	p.Y367C		NM_001010853	NP_001010853	Q8IYS1	P20D2_HUMAN	aminoacylase 1-like 2	367							hydrolase activity				0		all_cancers(76;9.47e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00813)		ATTCATCCATATTTTCACATT	0.368			NA											25	67					0	0	0.008361	0	0
COL10A1	1300	broad.mit.edu	37	6	116441292	116441292	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:116441292A>G	uc003pwm.2	-	3	2083	c.1987T>C	c.(1987-1989)TAC>CAC	p.Y663H	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	663	Nonhelical region (NC1).|C1q.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		TCAGAGGAGTATAGGCCATTT	0.478			NA											14	68					0	0	0.001855	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599090	136599090	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:136599090G>T	uc003qgx.1	-	4	1182	c.929C>A	c.(928-930)GCT>GAT	p.A310D	BCLAF1_uc003qgw.1_Missense_Mutation_p.A310D|BCLAF1_uc003qgy.1_Missense_Mutation_p.A308D|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.A308D	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	310					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATCTCTTGGAGCATTCTGTGG	0.433	Colon(142;1534 1789 5427 7063 28491)		NA											19	88					7.41877e-09	1.03523e-08	0.012319	1	0
TIAM2	26230	broad.mit.edu	37	6	155458398	155458398	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:155458398G>T	uc003qqb.2	+	7	2555	c.1282G>T	c.(1282-1284)GCT>TCT	p.A428S	TIAM2_uc003qqe.2_Missense_Mutation_p.A428S|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	428					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCAGGCATCTGCTTTTCTGTG	0.527			NA											11	69					2.80697e-09	3.96231e-09	0.010729	1	0
IGF2R	3482	broad.mit.edu	37	6	160499257	160499257	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:160499257A>T	uc003qta.2	+	37	5489	c.5341A>T	c.(5341-5343)AGC>TGC	p.S1781C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1781	Lumenal (Potential).|12.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GTTAAGGACCAGCGAGTGCGA	0.532			NA											8	87					0	0	0.008291	0	0
AGPAT4	56895	broad.mit.edu	37	6	161575192	161575192	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr6:161575192C>A	uc003qtr.1	-	4	726	c.499G>T	c.(499-501)GAG>TAG	p.E167*	AGPAT4_uc003qts.1_Nonsense_Mutation_p.E27*|AGPAT4_uc011egb.1_Intron|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Nonsense_Mutation_p.E167*|AGPAT4_uc011egd.1_Nonsense_Mutation_p.E105*|AGPAT4_uc011ege.1_Missense_Mutation_p.R110L	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	167					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		AAATACTTCTCGGGGTAGTCC	0.577			NA											7	36					0.00307968	0.00339322	0.00308	1	0
PRPS1L1	221823	broad.mit.edu	37	7	18067064	18067064	+	Silent	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:18067064A>G	uc003stz.2	-	1	423	c.342T>C	c.(340-342)AAT>AAC	p.N114N		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	114					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TAGAGAGCATATTTGCAACAA	0.473			NA											20	63					0	0	0.010504	0	0
GPR141	353345	broad.mit.edu	37	7	37780793	37780793	+	Missense_Mutation	SNP	C	C	A	rs146749644	byFrequency	TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:37780793C>A	uc003tfm.1	+	1	798	c.798C>A	c.(796-798)AAC>AAA	p.N266K	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	266	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						CATTTTATAACGAAATCTTCT	0.383			NA											12	221					5.50884e-06	6.93231e-06	0.013537	1	0
CDK13	8621	broad.mit.edu	37	7	40127867	40127867	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:40127867A>G	uc003thh.3	+	12	3454	c.3172A>G	c.(3172-3174)ACA>GCA	p.T1058A	CDK13_uc003thi.3_Missense_Mutation_p.T1058A|CDK13_uc003thj.2_Missense_Mutation_p.T109A	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1058					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						CAGAACCAACACACCCCAGGG	0.502			NA											5	54					0	0	0.00308	0	0
POLM	27434	broad.mit.edu	37	7	44119252	44119252	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:44119252T>C	uc003tjt.2	-	4	652	c.560A>G	c.(559-561)AAG>AGG	p.K187R	POLM_uc003tju.2_Missense_Mutation_p.K187R|POLM_uc003tjx.2_Missense_Mutation_p.K187R|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Intron|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Missense_Mutation_p.K187R|POLM_uc011kbu.1_Missense_Mutation_p.K154R|POLM_uc010kxy.2_Missense_Mutation_p.K187R	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	187					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						GGGAAGGGCCTTGAGCACCGA	0.622			NA						DNA_polymerases_(catalytic_subunits)					31	44					0	0	0.003271	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560666	44560666	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:44560666C>A	uc003tlb.2	-	13	3061	c.3005G>T	c.(3004-3006)AGG>ATG	p.R1002M	NPC1L1_uc003tlc.2_Missense_Mutation_p.R1002M|NPC1L1_uc011kbw.1_Missense_Mutation_p.R956M|NPC1L1_uc003tla.2_Missense_Mutation_p.R5M	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1002	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	CACCGAGGGCCTCACAGAGCC	0.567			NA											35	215					5.71845e-15	9.37672e-15	0.005524	1	0
WBSCR17	64409	broad.mit.edu	37	7	71142242	71142242	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:71142242T>A	uc003tvy.2	+	9	1451	c.1451T>A	c.(1450-1452)CTG>CAG	p.L484Q	WBSCR17_uc003tvz.2_Missense_Mutation_p.L183Q	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	484	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CAGGGGCCGCTGGAGAACCAC	0.537			NA											19	179					0	0	0.007413	0	0
PTPN12	5782	broad.mit.edu	37	7	77261701	77261701	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:77261701C>T	uc003ugh.2	+	14	2124	c.2033C>T	c.(2032-2034)CCT>CTT	p.P678L	PTPN12_uc011kgp.1_Missense_Mutation_p.P559L|PTPN12_uc011kgq.1_Missense_Mutation_p.P548L|PTPN12_uc010lds.2_Missense_Mutation_p.P410L	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	678						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						CCTCCCCTACCTGAAAGAACT	0.318			NA											57	104					0	0	0.01441	0	0
RSBN1L	222194	broad.mit.edu	37	7	77378976	77378976	+	Silent	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:77378976T>C	uc010ldt.1	+	3	983	c.939T>C	c.(937-939)TAT>TAC	p.Y313Y	RSBN1L_uc003ugm.2_Silent_p.Y95Y	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	313						nucleus				ovary(1)	1						CCAAGAACTATGATTCCAAAA	0.378			NA											39	57					0	0	0.006999	0	0
PCLO	27445	broad.mit.edu	37	7	82791757	82791757	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:82791757T>C	uc003uhx.2	-	1	441	c.152A>G	c.(151-153)GAG>GGG	p.E51G	PCLO_uc003uhv.2_Missense_Mutation_p.E51G	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	51					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCTCCTCTCCTCTTCGCTCAG	0.701			NA											2	3					0	0	0.004672	0	0
MUC17	140453	broad.mit.edu	37	7	100676470	100676470	+	Silent	SNP	A	A	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:100676470A>C	uc003uxp.1	+	3	1826	c.1773A>C	c.(1771-1773)TCA>TCC	p.S591S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	591	Extracellular (Potential).|7.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCACCACTTCAACAACTCCTG	0.483			NA											22	183					0	0	0.00333	0	0
DOCK4	9732	broad.mit.edu	37	7	111368560	111368560	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:111368560C>A	uc003vfx.2	-	52	5940	c.5671G>T	c.(5671-5673)GAG>TAG	p.E1891*	DOCK4_uc011kml.1_Nonsense_Mutation_p.E772*|DOCK4_uc011kmm.1_Nonsense_Mutation_p.E760*|DOCK4_uc003vfw.2_Nonsense_Mutation_p.E1303*|DOCK4_uc003vfy.2_Nonsense_Mutation_p.E1936*|DOCK4_uc003vfv.2_Nonsense_Mutation_p.E204*	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1891	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CGCACTGGCTCCTCCCCGCCG	0.667			NA											9	28					1.58986e-06	2.08135e-06	0.008291	1	0
TMEM209	84928	broad.mit.edu	37	7	129842495	129842495	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:129842495G>A	uc003vpn.2	-	4	331	c.208C>T	c.(208-210)CTT>TTT	p.L70F	TMEM209_uc010lmc.1_Missense_Mutation_p.L70F|TMEM209_uc003vpo.2_Missense_Mutation_p.L70F	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	70	Helical; (Potential).					integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					AGAGATGCAAGGGCAAGCTCT	0.388			NA											17	24					0	0	0.004007	0	0
CPA4	51200	broad.mit.edu	37	7	129950739	129950739	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:129950739G>A	uc003vpr.2	+	9	953	c.906G>A	c.(904-906)AAG>AAA	p.K302K	CPA4_uc011kpd.1_Silent_p.K269K|CPA4_uc011kpe.1_Silent_p.K198K	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	302					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GGAATTTCAAGGGCTTCATCG	0.512			NA											25	163					0	0	0.010818	0	0
KCNH2	3757	broad.mit.edu	37	7	150649748	150649748	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:150649748G>T	uc003wic.2	-	6	1335	c.1322C>A	c.(1321-1323)CCT>CAT	p.P441H	KCNH2_uc003wib.2_Missense_Mutation_p.P101H|KCNH2_uc011kux.1_Missense_Mutation_p.P345H|KCNH2_uc003wid.2_Missense_Mutation_p.P101H|KCNH2_uc003wie.2_Missense_Mutation_p.P441H	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	441	Extracellular (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CTCGGTAGCAGGCGGGCCTTC	0.602	GBM(137;110 1844 13671 20123 45161)		NA											40	59					1.49673e-21	2.7097e-21	0.00623	1	0
ESYT2	57488	broad.mit.edu	37	7	158534254	158534254	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr7:158534254C>A	uc003wob.1	-	17	2275	c.2209G>T	c.(2209-2211)GCC>TCC	p.A737S	ESYT2_uc003woc.1_Missense_Mutation_p.A561S|ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Missense_Mutation_p.A176S|ESYT2_uc003woa.1_Missense_Mutation_p.A314S	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	765						integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TCCTGGGTGGCGATGGGCAGC	0.637			NA											5	39					0.00116845	0.00131114	0.001168	1	0
RP1L1	94137	broad.mit.edu	37	8	10470795	10470795	+	Silent	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:10470795C>G	uc003wtc.2	-	4	1042	c.813G>C	c.(811-813)ACG>ACC	p.T271T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	271					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCAGCCGTGGCGTGCTGCCTG	0.647			NA											25	49					0	0	0.004656	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19297443	19297443	+	Splice_Site	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:19297443C>G	uc011kyn.1	-	6	1916	c.852_splice	c.e6-1	p.R284_splice	CSGALNACT1_uc011kyo.1_Splice_Site_p.R284_splice|CSGALNACT1_uc003wzg.2_Splice_Site|CSGALNACT1_uc011kyp.1_Splice_Site_p.R283_splice|CSGALNACT1_uc003wzh.2_Intron	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate						anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GCACATCTCCCTGGAAAACAA	0.413			NA											10	32					0	0	0.010729	0	0
STC1	6781	broad.mit.edu	37	8	23711941	23711941	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:23711941G>T	uc003xdw.1	-	1	380	c.96C>A	c.(94-96)TCC>TCA	p.S32S		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	32					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		CCGCCACTCGGGATTTCCTGG	0.532			NA											10	46					7.48243e-07	9.87518e-07	0.006214	1	0
C8orf80	389643	broad.mit.edu	37	8	27886883	27886883	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:27886883C>A	uc003xgm.3	-	17	2197	c.2054G>T	c.(2053-2055)CGG>CTG	p.R685L		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	685						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		ATCTTTCATCCGCTCACACGC	0.522			NA											3	16					6.4e-05	7.65967e-05	0.004672	1	0
TEX15	56154	broad.mit.edu	37	8	30705647	30705647	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:30705647C>T	uc003xil.2	-	1	887	c.887G>A	c.(886-888)TGT>TAT	p.C296Y		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	296										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TATTTTATCACAGCTTTTCCC	0.303			NA											22	35					0	0	0.012319	0	0
KCNU1	157855	broad.mit.edu	37	8	36694348	36694348	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:36694348C>A	uc010lvw.2	+	14	1490	c.1403C>A	c.(1402-1404)ACC>AAC	p.T468N	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	468	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AACTGGGACACCGGAGACAAC	0.443			NA											27	43					3.73988e-18	6.48158e-18	0.00632	1	0
SNTG1	54212	broad.mit.edu	37	8	51621516	51621516	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:51621516T>C	uc010lxy.1	+	18	1633	c.1262T>C	c.(1261-1263)ATC>ACC	p.I421T	SNTG1_uc003xqs.1_Missense_Mutation_p.I421T|SNTG1_uc010lxz.1_Missense_Mutation_p.I421T|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	421					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ACAGGATTTATCTGCTTTGAT	0.373			NA											13	53					0	0	0.001855	0	0
SOX17	64321	broad.mit.edu	37	8	55370910	55370910	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:55370910C>A	uc003xsb.3	+	1	416	c.212C>A	c.(211-213)CCG>CAG	p.P71Q		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	71	HMG box.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			ATCCGGCGGCCGATGAACGCT	0.677			NA											6	15					3.59834e-05	4.39195e-05	0.001168	1	0
RP1	6101	broad.mit.edu	37	8	55537445	55537445	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:55537445A>T	uc003xsd.1	+	4	1151	c.1003A>T	c.(1003-1005)ATG>TTG	p.M335L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	335					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GACAGTTGAGATGAAAGTTCG	0.318	Colon(91;1014 1389 7634 14542 40420)		NA											12	29					0	0	0.010729	0	0
GGH	8836	broad.mit.edu	37	8	63927974	63927974	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:63927974C>A	uc003xuw.2	-	9	1157	c.874G>T	c.(874-876)GAG>TAG	p.E292*		NM_003878	NP_003869	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase precursor	292	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	GCTTTCTCCTCTTCAGATTCA	0.279			NA											4	26					0.00909568	0.00973538	0.009096	1	0
KCNB2	9312	broad.mit.edu	37	8	73848769	73848769	+	Silent	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:73848769A>T	uc003xzb.2	+	3	1767	c.1179A>T	c.(1177-1179)CTA>CTT	p.L393L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	393					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AAACATTACTAGGGAAAATTG	0.438			NA											27	58					0	0	0.005443	0	0
KCNB2	9312	broad.mit.edu	37	8	73850219	73850219	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:73850219G>T	uc003xzb.2	+	3	3217	c.2629G>T	c.(2629-2631)GAC>TAC	p.D877Y		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	877	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGTCAAAAAGGACAGTAGTCA	0.488			NA											11	64					5.16669e-11	7.76598e-11	0.010729	1	0
FABP9	646480	broad.mit.edu	37	8	82370629	82370629	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:82370629C>T	uc011lfo.1	-	4	388	c.388G>A	c.(388-390)GAA>AAA	p.E130K		NM_001080526	NP_001073995	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	130							lipid binding|transporter activity				0			Epithelial(68;0.186)			CACACCTTTTCGTAGATTCTG	0.398			NA											10	79					0	0	0.001855	0	0
FAM82B	51115	broad.mit.edu	37	8	87498840	87498840	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:87498840C>A	uc003ydu.2	-	4	528	c.368G>T	c.(367-369)CGG>CTG	p.R123L	FAM82B_uc011lfz.1_Missense_Mutation_p.R123L|FAM82B_uc011lga.1_Missense_Mutation_p.R123L	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	123						microtubule|spindle pole	binding			ovary(1)	1						ACGTGATGCCCGTGCCAAACG	0.373			NA											33	41					4.4194e-11	6.684e-11	0.013726	1	0
CNBD1	168975	broad.mit.edu	37	8	88249219	88249220	+	Missense_Mutation	DNP	TG	TG	GA			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:88249219_88249220TG>GA	uc003ydy.2	+	6	698_699	c.650_651TG>GA	c.(649-651)CTG>CGA	p.L217R		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	217										ovary(3)	3						TATAAAAATCTGATTGAAGGAA	0.361			NA											62	67					0	0	0.004672	0	0
TMEM67	91147	broad.mit.edu	37	8	94808196	94808196	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:94808196G>C	uc011lgk.1	+	18	1912	c.1841G>C	c.(1840-1842)GGA>GCA	p.G614A	TMEM67_uc010maw.2_Missense_Mutation_p.G320A|TMEM67_uc003yga.3_Missense_Mutation_p.G533A|TMEM67_uc011lgl.1_Missense_Mutation_p.G13A	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	614	Helical; (Potential).				cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			ACTTATGTTGGATGTGCCTTT	0.328			NA											26	154					0	0	0.008361	0	0
FBXO43	286151	broad.mit.edu	37	8	101153696	101153696	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:101153696G>A	uc003yjd.2	-	2	1499	c.786C>T	c.(784-786)ATC>ATT	p.I262I	FBXO43_uc003yje.2_Silent_p.I228I|FBXO43_uc010mbp.1_Silent_p.I262I	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	262					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			AGTCATGTGTGATAGAGTCTT	0.378			NA											26	33					0	0	0.00333	0	0
TM7SF4	81501	broad.mit.edu	37	8	105360984	105360984	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:105360984G>A	uc003ylx.1	+	2	253	c.204G>A	c.(202-204)ACG>ACA	p.T68T		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	68	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGATTATCACGTGTGTTCTGC	0.507			NA											7	88					0	0	0.00308	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110487490	110487490	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:110487490G>A	uc003yne.2	+	51	8853	c.8749G>A	c.(8749-8751)GGA>AGA	p.G2917R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2917	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACATTCTATGGATTCAAGGT	0.353			NA								HNSCC(38;0.096)			6	34					0	0	0.001168	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110520355	110520355	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:110520355C>T	uc003yne.2	+	70	11361	c.11257C>T	c.(11257-11259)CTT>TTT	p.L3753F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3753	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTGTAAGTACCTTCCAGAGTG	0.353			NA								HNSCC(38;0.096)			14	84					0	0	0.004007	0	0
CSMD3	114788	broad.mit.edu	37	8	113246614	113246614	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:113246614T>A	uc003ynu.2	-	68	10879	c.10720A>T	c.(10720-10722)AAT>TAT	p.N3574Y	CSMD3_uc003yns.2_Missense_Mutation_p.N2776Y|CSMD3_uc003ynt.2_Missense_Mutation_p.N3534Y|CSMD3_uc011lhx.1_Missense_Mutation_p.N3405Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3574	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATTGCCCAATTTTCTTCCTTC	0.348			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	148					0	0	0.00499	0	0
TRPS1	7227	broad.mit.edu	37	8	116632271	116632271	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:116632271C>T	uc003ynz.2	-	2	474	c.15G>A	c.(13-15)AAG>AAA	p.K5K	TRPS1_uc011lhy.1_Silent_p.K9K|TRPS1_uc003yny.2_Silent_p.K18K|TRPS1_uc010mcy.2_Silent_p.K5K	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	5					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAGGGGGGTTCTTTTTCCGGA	0.413			NA							Langer-Giedion_syndrome				3	51					0	0	0.009096	0	0
COL14A1	7373	broad.mit.edu	37	8	121259871	121259871	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr8:121259871G>T	uc003yox.2	+	21	2764	c.2499G>T	c.(2497-2499)CAG>CAT	p.Q833H	COL14A1_uc003yoy.2_Missense_Mutation_p.Q511H	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	833	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CGGGGCCCCAGAACTTGCGGG	0.463			NA											8	64					5.4927e-09	7.68663e-09	0.004482	1	0
C9orf93	203238	broad.mit.edu	37	9	15784564	15784564	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:15784564C>T	uc003zmd.2	+	21	3454	c.3139C>T	c.(3139-3141)CTT>TTT	p.L1047F	C9orf93_uc003zme.2_Missense_Mutation_p.L962F|C9orf93_uc011lmu.1_Missense_Mutation_p.L1055F|C9orf93_uc003zmf.1_Missense_Mutation_p.L355F	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1047	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		TAATGCATTACTTCGGGAAGA	0.383			NA											18	28					0	0	0.006122	0	0
PTENP1	11191	broad.mit.edu	37	9	33676393	33676393	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:33676393G>A	uc003zth.3	-	1	1026	c.155C>T	c.(154-156)GCG>GTG	p.A52V		NR_023917				SubName: Full=Phosphatase and tensin homolog 2; Flags: Fragment;												0						AGGATATTGCGCAACTCTGTA	0.368			NA											23	43					0	0	0.00278	0	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420299	69420299	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:69420299A>C	uc004afn.2	+	13	1301	c.1189A>C	c.(1189-1191)ATA>CTA	p.I397L		NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	397											0						AAGTGAAAAAATACAACTTTC	0.289			NA											4	59					0	0	0.001984	0	0
PAPPA	5069	broad.mit.edu	37	9	119065156	119065156	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:119065156C>A	uc004bjn.2	+	10	3455	c.3074C>A	c.(3073-3075)TCC>TAC	p.S1025Y	PAPPA_uc011lxp.1_Missense_Mutation_p.S720Y|PAPPA_uc011lxq.1_Missense_Mutation_p.S400Y	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1025					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CAGTGGGCATCCAATGCTTCA	0.502			NA											12	39					6.40141e-05	7.65967e-05	0.010729	1	0
ASTN2	23245	broad.mit.edu	37	9	119625875	119625875	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:119625875G>T	uc004bjs.1	-	11	2128	c.2027C>A	c.(2026-2028)TCC>TAC	p.S676Y	ASTN2_uc004bjr.1_Missense_Mutation_p.S672Y|ASTN2_uc004bjt.1_Missense_Mutation_p.S625Y	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	676	Extracellular (Potential).|EGF-like 2.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						ACATCCCGAGGAATCCACCTG	0.607			NA											6	22					8.12818e-05	9.60783e-05	0.001984	1	0
TLR4	7099	broad.mit.edu	37	9	120476448	120476448	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:120476448C>A	uc004bjz.2	+	3	2333	c.2042C>A	c.(2041-2043)TCA>TAA	p.S681*	TLR4_uc004bka.2_Nonsense_Mutation_p.S641*|TLR4_uc004bkb.2_Nonsense_Mutation_p.S481*	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	681	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GTTATCTACTCAAGCCAGGAT	0.428			NA											23	40					1.64293e-13	2.61473e-13	0.00333	1	0
OR1N1	138883	broad.mit.edu	37	9	125288841	125288841	+	Silent	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:125288841G>A	uc004bmn.1	-	1	732	c.732C>T	c.(730-732)TGC>TGT	p.C244C		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						CACAAACAACGCAGAGGTGGG	0.552			NA											5	21					0	0	0.001168	0	0
TSC1	7248	broad.mit.edu	37	9	135797349	135797349	+	Nonsense_Mutation	SNP	C	C	A	rs118203392		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:135797349C>A	uc004cca.2	-	7	754	c.520G>T	c.(520-522)GAA>TAA	p.E174*	TSC1_uc004ccb.3_Nonsense_Mutation_p.E174*|TSC1_uc011mcq.1_Nonsense_Mutation_p.E123*|TSC1_uc011mcr.1_Nonsense_Mutation_p.E53*|TSC1_uc011mcs.1_Nonsense_Mutation_p.E53*|TSC1_uc004ccc.1_Nonsense_Mutation_p.E174*|TSC1_uc004ccd.2_Nonsense_Mutation_p.E174*|TSC1_uc004cce.1_Nonsense_Mutation_p.E174*	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	174					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AGATAGACTTCCGCCACGTGG	0.483			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				15	47					2.32078e-09	3.29511e-09	0.003163	1	0
KCNT1	57582	broad.mit.edu	37	9	138670655	138670655	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:138670655C>T	uc011mdq.1	+	23	2790	c.2716C>T	c.(2716-2718)CAG>TAG	p.Q906*	KCNT1_uc011mdr.1_Nonsense_Mutation_p.Q733*|KCNT1_uc010nbf.2_Nonsense_Mutation_p.Q861*|KCNT1_uc004cgo.1_Nonsense_Mutation_p.Q655*	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	906						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CGTCAACGTGCAGACCATGTT	0.637			NA											4	19					0	0	0.009096	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070116	141070116	+	Missense_Mutation	SNP	G	G	A	rs142836124	by1000genomes	TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:141070116G>A	uc004com.2	+	3	275	c.14G>A	c.(13-15)CGC>CAC	p.R5H	TUBBP5_uc010ncq.2_Missense_Mutation_p.R119H					RecName: Full=Putative tubulin beta-4q chain;												0						GACTCTGTGCGCTCGGGGCCC	0.687			NA											4	45					0	0	0.009096	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070139	141070139	+	Missense_Mutation	SNP	C	C	T	rs143443709	by1000genomes	TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:141070139C>T	uc004com.2	+	3	298	c.37C>T	c.(37-39)CTC>TTC	p.L13F	TUBBP5_uc010ncq.2_Missense_Mutation_p.L127F					RecName: Full=Putative tubulin beta-4q chain;												0						CGGGCAGGTCCTCAGGCCAGA	0.667			NA											4	48					0	0	0.009096	0	0
BEND2	139105	broad.mit.edu	37	X	18183163	18183163	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:18183163G>A	uc004cyj.3	-	14	2520	c.2366C>T	c.(2365-2367)CCA>CTA	p.P789L		NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	789										ovary(3)|kidney(1)|central_nervous_system(1)	5						GGGATCTCCTGGCTTTGACTC	0.498			NA											33	129					0	0	0.004289	0	0
SCML2	10389	broad.mit.edu	37	X	18260586	18260587	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:18260586_18260587GC>TT	uc004cyl.2	-	14	2103_2104	c.1946_1947GC>AA	c.(1945-1947)GGC>GAA	p.G649E	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron|SCML2_uc010nfc.2_Intron	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	649	SAM.				anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CGGCGAGGGGGCCTGATATCTG	0.475	Esophageal Squamous(100;1252 1965 19021 35517)		NA											16	42					0	0	0.004672	0	0
CDKL5	6792	broad.mit.edu	37	X	18622582	18622582	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:18622582C>T	uc004cym.2	+	12	1791	c.1538C>T	c.(1537-1539)ACC>ATC	p.T513I	CDKL5_uc004cyn.2_Missense_Mutation_p.T513I	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	513					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GAGCCCAGTACCAGTAGGTAC	0.552			NA											22	114					0	0	0.00278	0	0
MAP3K15	389840	broad.mit.edu	37	X	19379644	19379644	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:19379644C>A	uc004czk.1	-	28	3809	c.2172G>T	c.(2170-2172)CGG>CGT	p.R724R	MAP3K15_uc004czj.1_Silent_p.R684R|PDHA1_uc004czg.3_3'UTR|PDHA1_uc004czh.3_3'UTR|PDHA1_uc011mjc.1_3'UTR|PDHA1_uc011mjd.1_3'UTR|PDHA1_uc010nfk.2_3'UTR|PDHA1_uc010nfl.2_3'UTR|MAP3K15_uc004czi.1_Silent_p.R183R	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	1249							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					CTCCTTGCAGCCGCAACCAGT	0.413			NA											39	143					1.34996e-11	2.05448e-11	0.009718	1	0
ZNF645	158506	broad.mit.edu	37	X	22292161	22292161	+	Silent	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:22292161T>A	uc004dai.1	+	1	1102	c.1053T>A	c.(1051-1053)TCT>TCA	p.S351S		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	351						intracellular	zinc ion binding			lung(1)|pancreas(1)	2						GTAATCCATCTGCAAGTGAAT	0.408			NA											26	63					0	0	0.004656	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237051	30237051	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:30237051G>T	uc004dbz.2	+	2	457	c.354G>T	c.(352-354)TTG>TTT	p.L118F		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	118	MAGE.						protein binding			ovary(1)	1						CAGGGTCGTTGGTGCAGTTCC	0.463			NA											3	19					0.004672	0.00507871	0.004672	1	0
MAGEB1	4112	broad.mit.edu	37	X	30268940	30268940	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:30268940G>T	uc004dcc.2	+	4	650	c.330G>T	c.(328-330)TGG>TGT	p.W110C	MAGEB1_uc004dcd.2_Missense_Mutation_p.W110C|MAGEB1_uc004dce.2_Missense_Mutation_p.W110C	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	110	MAGE.										0						CTGTAGCCTGGGAGGCAGGAA	0.463			NA											8	23					1.06961e-07	1.45911e-07	0.00308	1	0
NR0B1	190	broad.mit.edu	37	X	30326434	30326434	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:30326434G>T	uc004dcf.3	-	1	1062	c.1047C>A	c.(1045-1047)GCC>GCA	p.A349A		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	349	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	GCACCTTCCTGGCCTCCGCCG	0.627			NA									OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	14					2.0095e-06	2.59582e-06	0.001984	1	0
DMD	1756	broad.mit.edu	37	X	31200972	31200972	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:31200972C>T	uc004dda.1	-	68	10101	c.9857G>A	c.(9856-9858)AGA>AAA	p.R3286K	DMD_uc004dcq.1_Missense_Mutation_p.R557K|DMD_uc004dcr.1_Missense_Mutation_p.R826K|DMD_uc004dcs.1_Missense_Mutation_p.R826K|DMD_uc004dct.1_Missense_Mutation_p.R826K|DMD_uc004dcu.1_Missense_Mutation_p.R826K|DMD_uc004dcv.1_Missense_Mutation_p.R826K|DMD_uc004dcw.2_Missense_Mutation_p.R1942K|DMD_uc004dcx.2_Missense_Mutation_p.R1945K|DMD_uc004dcz.2_Missense_Mutation_p.R3163K|DMD_uc004dcy.1_Missense_Mutation_p.R3282K|DMD_uc004ddb.1_Missense_Mutation_p.R3278K|DMD_uc004dcm.1_Missense_Mutation_p.R218K|DMD_uc004dcn.1_Missense_Mutation_p.R218K|DMD_uc004dco.1_Missense_Mutation_p.R218K|DMD_uc004dcp.1_Missense_Mutation_p.R218K|DMD_uc011mkb.1_Missense_Mutation_p.R218K|DMD_uc010ngm.2_Missense_Mutation_p.R218K	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3286	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGGTTCCAGTCTCATCCAGTC	0.522			NA											22	39					0	0	0.012319	0	0
DMD	1756	broad.mit.edu	37	X	32305735	32305735	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:32305735C>A	uc004dda.1	-	43	6445	c.6201G>T	c.(6199-6201)ACG>ACT	p.T2067T	DMD_uc004dcw.2_Silent_p.T723T|DMD_uc004dcx.2_Silent_p.T726T|DMD_uc004dcz.2_Silent_p.T1944T|DMD_uc004dcy.1_Silent_p.T2063T|DMD_uc004ddb.1_Silent_p.T2059T|DMD_uc010ngo.1_Intron|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2067	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTCCACAGGCGTTGCACTTT	0.398			NA											26	50					2.50493e-22	4.5861e-22	0.004656	1	0
DMD	1756	broad.mit.edu	37	X	32407765	32407765	+	Silent	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:32407765C>T	uc004dda.1	-	32	4615	c.4371G>A	c.(4369-4371)AAG>AAA	p.K1457K	DMD_uc004dcw.2_Silent_p.K113K|DMD_uc004dcx.2_Silent_p.K116K|DMD_uc004dcz.2_Silent_p.K1334K|DMD_uc004dcy.1_Silent_p.K1453K|DMD_uc004ddb.1_Silent_p.K1449K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1457	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATAATCGAAACTTCATGGAGA	0.343			NA											12	94					0	0	0.003163	0	0
FAM47B	170062	broad.mit.edu	37	X	34962613	34962613	+	Silent	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:34962613T>A	uc004ddi.1	+	1	1683	c.1665T>A	c.(1663-1665)CCT>CCA	p.P555P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	555										ovary(3)|breast(1)	4						ACTTCGAGCCTAAGTTGGGGA	0.493			NA											46	51					0	0	0.013114	0	0
CXorf59	286464	broad.mit.edu	37	X	36122645	36122645	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:36122645C>A	uc004ddk.1	+	8	1068	c.882C>A	c.(880-882)TAC>TAA	p.Y294*		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	294						integral to membrane				central_nervous_system(1)	1						TAGTGCCATACTGCAGCAATA	0.343			NA											34	92					1.60099e-16	2.67014e-16	0.004878	1	0
CHST7	56548	broad.mit.edu	37	X	46433945	46433945	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:46433945C>A	uc004dgt.2	+	1	754	c.579C>A	c.(577-579)TTC>TTA	p.F193L		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	193	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						CCGCCCTCTTCCGCTGGCGGA	0.562			NA											4	7					0.00024832	0.000285217	0.009096	1	0
SSX6	280657	broad.mit.edu	37	X	47976475	47976475	+	Missense_Mutation	SNP	A	A	C	rs17327911		TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:47976475A>C	uc004dix.1	+	6	534	c.412A>C	c.(412-414)AAG>CAG	p.K138Q		NM_173357	NP_775493			SubName: Full=Putative uncharacterized protein SSX1;												0						CGATGGGAAAAAGCTGTGCCC	0.507			NA											21	154					0	0	0.014323	0	0
APEX2	27301	broad.mit.edu	37	X	55033653	55033653	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:55033653G>T	uc004dtz.2	+	6	1418	c.1342G>T	c.(1342-1344)GAG>TAG	p.E448*	APEX2_uc011mom.1_Nonsense_Mutation_p.E277*	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	448					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						AGCCAAAGATGAGAAGGAGTT	0.587			NA						Other_BER_factors					7	33					0.00307968	0.00339322	0.00308	1	0
SPIN3	169981	broad.mit.edu	37	X	57021331	57021331	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:57021331C>T	uc010nkj.2	-	2	336	c.50G>A	c.(49-51)GGC>GAC	p.G17D	SPIN3_uc004duu.3_RNA|SPIN3_uc004duw.3_RNA|SPIN3_uc004duv.3_RNA|SPIN3_uc004dux.1_Missense_Mutation_p.G17D	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	17					gamete generation					ovary(1)|central_nervous_system(1)	2						GTGGCCAGCGCCCGTCCTGGA	0.587			NA											9	29					0	0	0.004482	0	0
ATRX	546	broad.mit.edu	37	X	76920220	76920220	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:76920220G>T	uc004ecp.3	-	11	4089	c.3857C>A	c.(3856-3858)TCT>TAT	p.S1286Y	ATRX_uc004ecq.3_Missense_Mutation_p.S1248Y|ATRX_uc004eco.3_Missense_Mutation_p.S1071Y|ATRX_uc004ecr.2_Missense_Mutation_p.S1218Y	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1286				S -> P (in Ref. 4; BAD92165).	DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATCCTCATCAGAGGAAAGATT	0.373			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						18	84					9.16793e-09	1.27565e-08	0.00499	1	0
MAGT1	84061	broad.mit.edu	37	X	77112246	77112246	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:77112246C>A	uc004fof.2	-	5	814	c.752G>T	c.(751-753)TGG>TTG	p.W251L	MAGT1_uc004fog.3_Intron	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	219	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						TGCAAAAGCCCATCCAGTTTT	0.328			NA											24	85					6.32553e-13	9.90525e-13	0.004656	1	0
ATP7A	538	broad.mit.edu	37	X	77275806	77275806	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:77275806G>T	uc004ecx.3	+	13	2852	c.2692G>T	c.(2692-2694)GGG>TGG	p.G898W		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	898	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TAACCAGAACGGGTCACTGCT	0.448			NA											13	81					9.31168e-06	1.16277e-05	0.001855	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912628	77912628	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:77912628G>T	uc004edc.1	-	2	1586	c.1290C>A	c.(1288-1290)CAC>CAA	p.H430Q		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	430							nucleic acid binding|zinc ion binding			ovary(1)	1						CTTCACTGATGTGTGGGCAGT	0.517			NA											18	54					5.35267e-07	7.14178e-07	0.007413	1	0
P2RY10	27334	broad.mit.edu	37	X	78216521	78216521	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:78216521C>A	uc004ede.2	+	4	873	c.504C>A	c.(502-504)CCC>CCA	p.P168P	P2RY10_uc004edf.2_Silent_p.P168P	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	168	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						TGCCATTTCCCATCCTGAGAA	0.502			NA											24	29					1.9806e-07	2.68677e-07	0.014323	1	0
BTK	695	broad.mit.edu	37	X	100615743	100615743	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:100615743T>C	uc004ehg.2	-	8	782	c.589A>G	c.(589-591)ATC>GTC	p.I197V	BTK_uc004ehf.2_5'Flank|BTK_uc010nnh.2_5'Flank|BTK_uc010nni.2_5'Flank|BTK_uc004ehe.2_5'Flank|BTK_uc010nnj.2_5'Flank|BTK_uc010nnk.2_5'Flank|BTK_uc010nnl.2_5'Flank|BTK_uc010nnm.2_5'Flank|BTK_uc010nnn.2_Missense_Mutation_p.I197V|BTK_uc010nno.2_Missense_Mutation_p.I231V|BTK_uc004ehh.1_5'Flank|BTK_uc004ehi.2_Missense_Mutation_p.I197V	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	197					calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TTTTTCAAGATCTATGTAGTT	0.473			NA							Agammaglobulinemia_X-linked				28	38					0	0	0.004656	0	0
BTK	695	broad.mit.edu	37	X	100617635	100617635	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:100617635C>G	uc004ehg.2	-	6	627	c.434G>C	c.(433-435)TGC>TCC	p.C145S	BTK_uc010nnn.2_Missense_Mutation_p.C145S|BTK_uc010nno.2_Missense_Mutation_p.C179S|BTK_uc004ehi.2_Missense_Mutation_p.C145S	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	145	Btk-type.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						GATCCAGAAGCAAGGGTGATA	0.458			NA							Agammaglobulinemia_X-linked				23	126					0	0	0.005443	0	0
BTK	695	broad.mit.edu	37	X	100630266	100630266	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:100630266C>A	uc004ehg.2	-	2	200	c.7G>T	c.(7-9)GCA>TCA	p.A3S	BTK_uc010nnn.2_Missense_Mutation_p.A3S|BTK_uc010nno.2_Missense_Mutation_p.A37S|BTK_uc004ehi.2_Missense_Mutation_p.A3S	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	3	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						AGAATCACTGCGGCCATAGCT	0.468			NA							Agammaglobulinemia_X-linked				15	125					3.41278e-10	5.06715e-10	0.00499	1	0
NXF2B	728343	broad.mit.edu	37	X	101576802	101576802	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:101576802C>A	uc004eiv.3	+	27	3170	c.1298C>A	c.(1297-1299)GCC>GAC	p.A433D	NXF2B_uc004eiu.3_Missense_Mutation_p.A433D|NXF2B_uc004eiw.3_Missense_Mutation_p.A345D|NXF2_uc004eix.3_Missense_Mutation_p.A433D	NM_001099686	NP_001093156	Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2B	433	NTF2.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			ovary(1)	1						AAGGACTCAGCCCCGTGAGTA	0.597			NA											6	89					0.00448238	0.00491649	0.004482	1	0
TSC22D3	1831	broad.mit.edu	37	X	107018416	107018416	+	Silent	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:107018416C>A	uc004enh.2	-	1	602	c.234G>T	c.(232-234)CTG>CTT	p.L78L	TSC22D3_uc004eni.2_Silent_p.L78L|TSC22D3_uc004enj.2_Silent_p.L78L	NM_198057	NP_932174	Q99576	T22D3_HUMAN	TSC22 domain family, member 3 isoform 1	Error:Variant_position_missing_in_Q99576_after_alignment							sequence-specific DNA binding transcription factor activity				0						AGGGGTCCCGCAGCACCGGCT	0.567			NA											11	53					4.3838e-07	5.86514e-07	0.001855	1	0
ZCCHC16	340595	broad.mit.edu	37	X	111698402	111698402	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:111698402A>T	uc004epo.1	+	3	887	c.446A>T	c.(445-447)AAT>ATT	p.N149I		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	149							nucleic acid binding|zinc ion binding			ovary(1)	1						CCTCTGATGAATGCTAAGTTT	0.423			NA											16	103					0	0	0.006122	0	0
WDR44	54521	broad.mit.edu	37	X	117526694	117526694	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:117526694A>C	uc004eqn.2	+	4	711	c.286A>C	c.(286-288)AGT>CGT	p.S96R	WDR44_uc004eqo.2_Missense_Mutation_p.S96R|WDR44_uc011mtr.1_Missense_Mutation_p.S71R|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	96	Binding activity.			S -> G (in Ref. 2; CAL38210).		cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						AGCTACTGCCAGTCCTATTGT	0.413			NA											18	97					0	0	0.010504	0	0
LAMP2	3920	broad.mit.edu	37	X	119576490	119576490	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:119576490C>G	uc004est.3	-	7	1072	c.892G>C	c.(892-894)GAA>CAA	p.E298Q	LAMP2_uc004ess.3_Missense_Mutation_p.E298Q|LAMP2_uc011mtz.1_Missense_Mutation_p.E187Q|LAMP2_uc011mua.1_Missense_Mutation_p.E251Q|LAMP2_uc010nqp.1_Missense_Mutation_p.E298Q	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	298	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						ATGTTCACTTCCTTCAGATAA	0.373			NA											52	305					0	0	0.01441	0	0
GRIA3	2892	broad.mit.edu	37	X	122616858	122616858	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:122616858G>A	uc004etq.3	+	16	2941	c.2648G>A	c.(2647-2649)GGC>GAC	p.G883D	GRIA3_uc004etr.3_Missense_Mutation_p.G883D|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	883	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TACAGAGAAGGCTACAACGTG	0.413			NA											15	104					0	0	0.004007	0	0
ODZ1	10178	broad.mit.edu	37	X	123556416	123556416	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:123556416T>A	uc004euj.2	-	23	4220	c.4156A>T	c.(4156-4158)ATT>TTT	p.I1386F	ODZ1_uc011muj.1_Missense_Mutation_p.I1392F|ODZ1_uc010nqy.2_Missense_Mutation_p.I1393F	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1386	NHL 3.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGCAGCACAATGTTGTTATCC	0.473			NA											15	102					0	0	0.00245	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128890490	128890490	+	Silent	SNP	C	C	G			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:128890490C>G	uc004eut.1	+	14	1570	c.1326C>G	c.(1324-1326)TCC>TCG	p.S442S		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	442					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						GCAAGCTGTCCTCAGATGAGA	0.602			NA											6	37					0	0	0.001168	0	0
AIFM1	9131	broad.mit.edu	37	X	129290567	129290567	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:129290567G>T	uc004evg.2	-	2	295	c.117C>A	c.(115-117)TTC>TTA	p.F39L	AIFM1_uc011mus.1_Missense_Mutation_p.F39L|AIFM1_uc004evh.2_Intron|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_Intron	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	39					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						GCCATCGCTGGAACAAGTTGC	0.358			NA											35	200					1.04594e-18	1.83889e-18	0.00623	1	0
FAM45B	55855	broad.mit.edu	37	X	129629173	129629173	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:129629173G>T	uc010nrh.2	+	1	259	c.41G>T	c.(40-42)GGA>GTA	p.G14V	uc004evu.2_RNA	NM_207009	NP_996892			hypothetical protein LOC404636											skin(1)	1				all cancers(201;0.0293)		CTGATGCTTGGAGTCGGGCTG	0.542			NA											18	19					3.52763e-06	4.49727e-06	0.00499	1	0
OR13H1	347468	broad.mit.edu	37	X	130678918	130678918	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:130678918C>A	uc011muw.1	+	1	871	c.871C>A	c.(871-873)CTG>ATG	p.L291M	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					GATATATAGCCTGAGAAAAAA	0.398			NA											45	100					4.18559e-23	7.692e-23	0.01441	1	0
GPC3	2719	broad.mit.edu	37	X	132887866	132887866	+	Silent	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:132887866G>T	uc004exe.1	-	3	865	c.675C>A	c.(673-675)GTC>GTA	p.V225V	GPC3_uc004exd.1_Silent_p.V97V|GPC3_uc010nrn.1_Silent_p.V225V|GPC3_uc011mvh.1_Silent_p.V209V|GPC3_uc010nro.1_Silent_p.V171V|GPC3_uc010nrp.1_Silent_p.V97V	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	225						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGATCCTAGTGACTTGCAGTG	0.463			NA	T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				18	95					4.96729e-08	6.83353e-08	0.008871	1	0
FAM122C	159091	broad.mit.edu	37	X	133988158	133988158	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:133988158G>T	uc004exz.1	+	7	885	c.480G>T	c.(478-480)ATG>ATT	p.M160I	FAM122C_uc011mvq.1_RNA|FAM122C_uc004exy.1_3'UTR	NM_138819	NP_620174	Q6P4D5	F222C_HUMAN	hypothetical protein LOC159091	160											0	Acute lymphoblastic leukemia(192;0.000127)					CGACAGCAATGCTGGATCTTC	0.418			NA											19	92					1.33834e-09	1.92263e-09	0.007413	1	0
GPR112	139378	broad.mit.edu	37	X	135431279	135431279	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:135431279C>T	uc004ezu.1	+	6	5705	c.5414C>T	c.(5413-5415)ACT>ATT	p.T1805I	GPR112_uc010nsb.1_Missense_Mutation_p.T1600I|GPR112_uc010nsc.1_Missense_Mutation_p.T1572I	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1805	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TTAGAAAAGACTTCCTTAACA	0.383			NA											35	88					0	0	0.013726	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596980	142596980	+	Silent	SNP	T	T	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:142596980T>A	uc004fbw.2	-	2	178	c.90A>T	c.(88-90)GTA>GTT	p.V30V		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	30										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTGTTTGGTACCTCTTGCA	0.393			NA											11	87					0	0	0.010729	0	0
CCKBR	887	broad.mit.edu	37	11	6291420	6291420	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr11:6291420delC	uc001mcp.2	+	3	699	c.506delC	c.(505-507)TCCfs	p.S169fs	CCKBR_uc001mcq.2_Frame_Shift_Del_p.S97fs|CCKBR_uc001mcr.2_Frame_Shift_Del_p.S169fs|CCKBR_uc001mcs.2_Frame_Shift_Del_p.S169fs	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	169	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	CAGACGCGCTCCCACGCGGCT	0.642			NA											11	16	---	---	---	---	NA	NA	NA	NA	NA
RNF219	79596	broad.mit.edu	37	13	79190706	79190707	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr13:79190706_79190707insA	uc001vkw.1	-	6	1248_1249	c.1189_1190insT	c.(1189-1191)TGCfs	p.C397fs	uc001vku.1_RNA|RNF219_uc010afb.1_Frame_Shift_Ins_p.C207fs|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	397							zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GAGCTGAAGGCAACTAAGGGAC	0.426			NA											22	125	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579481	7579482	+	Frame_Shift_Ins	INS	-	-	C			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr17:7579481_7579482insC	uc002gim.2	-	4	399_400	c.205_206insG	c.(205-207)GCTfs	p.A69fs	TP53_uc002gig.1_Frame_Shift_Ins_p.A69fs|TP53_uc002gih.2_Frame_Shift_Ins_p.A69fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.A69fs|TP53_uc010cni.1_Frame_Shift_Ins_p.A69fs|TP53_uc002gij.2_Frame_Shift_Ins_p.A69fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.A30fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.A84fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	69	Interaction with WWOX.|Interaction with HRMT1L2.		A -> D (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> T (in a sporadic cancer; somatic mutation).|A -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.A69G(3)|p.A69fs*54(1)|p.E68fs*76(1)|p.A69fs*79(1)|p.D48fs*55(1)|p.R65_P71delRMPEAAP(1)|p.A69V(1)|p.P13fs*18(1)|p.R65fs*38(1)|p.D57_A76del20(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGGAGCAGCCTCTGGCATT	0.609	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			102	86	---	---	---	---	NA	NA	NA	NA	NA
MANBA	4126	broad.mit.edu	37	4	103644031	103644031	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr4:103644031delC	uc003hwg.2	-	4	646	c.546delG	c.(544-546)CGGfs	p.R182fs	MANBA_uc011ces.1_Intron	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	182					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		CCATTACCTTCCGAACAAAGT	0.488			NA											14	37	---	---	---	---	NA	NA	NA	NA	NA
OR13C4	138804	broad.mit.edu	37	9	107288787	107288787	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chr9:107288787delT	uc011lvn.1	-	1	704	c.704delA	c.(703-705)CACfs	p.H235fs		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AAATGCCTTGTGTCTTCCTGT	0.423			NA											42	66	---	---	---	---	NA	NA	NA	NA	NA
CYBB	1536	broad.mit.edu	37	X	37664382	37664382	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:37664382delC	uc004ddr.2	+	10	1336	c.1275delC	c.(1273-1275)TACfs	p.Y425fs	CYBB_uc011mkf.1_Frame_Shift_Del_p.Y393fs|CYBB_uc011mkg.1_Frame_Shift_Del_p.Y158fs	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	425	Cytoplasmic (Potential).				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CAGTCTGGTACAAATATTGCA	0.483			NA											13	33	---	---	---	---	NA	NA	NA	NA	NA
STARD8	9754	broad.mit.edu	37	X	67937113	67937113	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-6211-01A-11D-1753-08	TCGA-75-6211-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d8c9abbe-b112-4019-a6a3-f582df1379ed	766b14bf-ca3c-429d-83f0-b01190caceb3	g.chrX:67937113delG	uc004dxa.2	+	5	489	c.117delG	c.(115-117)CAGfs	p.Q39fs	STARD8_uc004dxb.2_Frame_Shift_Del_p.Q119fs|STARD8_uc004dxc.3_Frame_Shift_Del_p.Q39fs	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	39					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						CCTTCCAGCAGGAAAGTAAGT	0.587			NA											7	7	---	---	---	---	NA	NA	NA	NA	NA
