Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF1B	23095	broad.mit.edu	37	1	10421830	10421830	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:10421830A>T	uc001aqx.3	+	40	4453	c.4251A>T	c.(4249-4251)CCA>CCT	p.P1417P	KIF1B_uc001aqw.3_Silent_p.P1371P|KIF1B_uc001aqy.2_Silent_p.P1391P|KIF1B_uc001aqz.2_Silent_p.P1417P|KIF1B_uc001ara.2_Silent_p.P1377P|KIF1B_uc001arb.2_Silent_p.P1403P	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1417					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AGATCTCACCACCACGCTCTC	0.502			NA											86	59					0	0	0.01441	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885059	12885059	+	Missense_Mutation	SNP	C	C	G	rs143004725	by1000genomes	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:12885059C>G	uc001auk.2	-	4	1248	c.1052G>C	c.(1051-1053)TGC>TCC	p.C351S		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	351	LRR 6.										0						GGTGGCCATGCAGATGGGATT	0.532			NA											4	242					0	0	0.009096	0	0
EIF2C3	192669	broad.mit.edu	37	1	36469988	36469988	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:36469988G>T	uc001bzp.2	+	6	961	c.705G>T	c.(703-705)ATG>ATT	p.M235I	EIF2C3_uc001bzq.2_Missense_Mutation_p.M1I	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	235					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTCAGTTCATGTGTGAAGTTC	0.328	Colon(144;60 2363 31043 40539)		NA											47	29					1.00776e-21	2.19724e-21	0.01441	1	0
SNIP1	79753	broad.mit.edu	37	1	38019710	38019710	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:38019710G>A	uc001cbi.2	-	1	194	c.121C>T	c.(121-123)CCC>TCC	p.P41S	SNIP1_uc010oid.1_RNA|DNALI1_uc001cbj.2_5'Flank|DNALI1_uc010oie.1_5'Flank	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	41					production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				CGGTGGGCGGGAGGTGCGACT	0.741			NA											8	16					0	0	0.00308	0	0
PTCH2	8643	broad.mit.edu	37	1	45294203	45294203	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:45294203G>A	uc010olf.1	-	12	1577	c.1565C>T	c.(1564-1566)CCT>CTT	p.P522L	PTCH2_uc010olg.1_Missense_Mutation_p.P220L	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	522	SSD.|Helical; (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCGCAGCGCAGGGATGGGAAC	0.632			NA							Basal_Cell_Nevus_syndrome				26	14					0	0	0.004656	0	0
LRRC7	57554	broad.mit.edu	37	1	70518799	70518799	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:70518799G>A	uc001dep.2	+	21	4117	c.4087G>A	c.(4087-4089)GAT>AAT	p.D1363N	LRRC7_uc009wbg.2_Missense_Mutation_p.D647N|LRRC7_uc001deq.2_Missense_Mutation_p.D557N	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1363						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGGGAGGCGGGATGTACCTCC	0.393			NA											46	12					0	0	0.011902	0	0
ACADM	34	broad.mit.edu	37	1	76205782	76205782	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:76205782G>A	uc001dgw.3	+	7	1016	c.586G>A	c.(586-588)GGA>AGA	p.G196R	ACADM_uc010orc.1_3'UTR|ACADM_uc010ord.1_Missense_Mutation_p.G110R|ACADM_uc009wbp.2_Missense_Mutation_p.G200R|ACADM_uc009wbr.2_Missense_Mutation_p.G229R|ACADM_uc010ore.1_Missense_Mutation_p.G160R|ACADM_uc010orf.1_Missense_Mutation_p.G7R|ACADM_uc001dgx.3_Missense_Mutation_p.G110R|ACADM_uc010org.1_Missense_Mutation_p.G66R	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	196					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						AACCAACGGAGGAAAAGCTAA	0.328			NA											29	29					0	0	0.013726	0	0
CDC14A	8556	broad.mit.edu	37	1	100928316	100928316	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:100928316C>T	uc001dtg.3	+	9	1205	c.717C>T	c.(715-717)GAC>GAT	p.D239D	CDC14A_uc009web.2_RNA|CDC14A_uc010oui.1_Silent_p.D181D|CDC14A_uc001dte.3_Silent_p.D239D|CDC14A_uc001dtf.2_Silent_p.D239D|CDC14A_uc009wed.1_Translation_Start_Site|CDC14A_uc009wee.2_Silent_p.D239D	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	239	B.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		GCTTCACAGACGCTGGCTTCG	0.473			NA											19	46					0	0	0.007413	0	0
SORT1	6272	broad.mit.edu	37	1	109867652	109867652	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:109867652T>C	uc001dxm.1	-	14	1752	c.1703A>G	c.(1702-1704)TAT>TGT	p.Y568C	SORT1_uc010ovi.1_Missense_Mutation_p.Y431C	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	568	Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		GCCAGTGAAATAGATGGGGTC	0.488			NA											37	26					0	0	0.004878	0	0
FLG	2312	broad.mit.edu	37	1	152280380	152280380	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:152280380C>T	uc001ezu.1	-	3	7018	c.6982G>A	c.(6982-6984)GAG>AAG	p.E2328K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2328	Ser-rich.|Filaggrin 14.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGTGTCTCTCTCCTGCACTT	0.552			NA							Ichthyosis				378	489					0	0	0.01441	0	0
IQGAP3	128239	broad.mit.edu	37	1	156532985	156532985	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:156532985C>T	uc001fpf.2	-	8	814	c.739G>A	c.(739-741)GTC>ATC	p.V247I	IQGAP3_uc009wsb.1_Missense_Mutation_p.V204I	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	247					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCTTGGTAGACGGCTGCCAGA	0.567			NA											47	290					0	0	0.013114	0	0
NES	10763	broad.mit.edu	37	1	156639506	156639506	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:156639506T>A	uc001fpq.2	-	4	4607	c.4474A>T	c.(4474-4476)AGT>TGT	p.S1492C		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1492	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCTCAGCACTGTCCTGGGAC	0.592			NA											38	89					0	0	0.006999	0	0
ADCY10	55811	broad.mit.edu	37	1	167830185	167830185	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:167830185G>A	uc001ger.2	-	15	2031	c.1733C>T	c.(1732-1734)ACC>ATC	p.T578I	ADCY10_uc009wvk.2_Missense_Mutation_p.T486I|ADCY10_uc010plj.1_Missense_Mutation_p.T425I|ADCY10_uc009wvl.2_Missense_Mutation_p.T577I	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	578					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TCGAAGGTTGGTCTGTCGTTC	0.363			NA											31	213					0	0	0.012213	0	0
SELE	6401	broad.mit.edu	37	1	169698396	169698396	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:169698396A>T	uc001ggm.3	-	7	1178	c.1021T>A	c.(1021-1023)TTG>ATG	p.L341M	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	341	Extracellular (Potential).|Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GGTCCCTGCAACATGAAGCCT	0.517			NA											63	80					0	0	0.01441	0	0
SLC9A11	284525	broad.mit.edu	37	1	173493964	173493964	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:173493964C>A	uc001giz.2	-	20	2891	c.2468G>T	c.(2467-2469)TGT>TTT	p.C823F	SLC9A11_uc009wwe.2_Missense_Mutation_p.C381F|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	823					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GCCTCTTGAACAAAGGAAGGT	0.398			NA											44	152					9.39024e-22	2.0558e-21	0.009718	1	0
UCHL5	51377	broad.mit.edu	37	1	192985498	192985498	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:192985498C>A	uc001gsm.2	-	11	1104	c.973G>T	c.(973-975)GCT>TCT	p.A325S	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Missense_Mutation_p.A324S|UCHL5_uc010pov.1_RNA	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	325	Interaction with ADRM1.				DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						GTTTCCTGAGCTTTCTTTGCG	0.284			NA											84	267					2.16659e-41	5.59527e-41	0.01441	1	0
CFHR5	81494	broad.mit.edu	37	1	196971705	196971705	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:196971705C>T	uc001gts.3	+	8	1369	c.1241C>T	c.(1240-1242)GCT>GTT	p.A414V		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	414	Sushi 7.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GAAAAAGTAGCTGTTCTCTGT	0.388			NA											43	48					0	0	0.007835	0	0
NR5A2	2494	broad.mit.edu	37	1	200012997	200012997	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:200012997C>A	uc001gvb.2	+	3	504	c.298C>A	c.(298-300)CTC>ATC	p.L100I	NR5A2_uc001gvc.2_Missense_Mutation_p.L54I|NR5A2_uc009wzh.2_Missense_Mutation_p.L60I|NR5A2_uc010pph.1_Missense_Mutation_p.L28I	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	100	Nuclear receptor.|NR C4-type.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCATTATGGGCTCCTCACCTG	0.398	Melanoma(179;1138 2773 15678 26136)		NA											24	46					1.85244e-09	3.38659e-09	0.00333	1	0
RCOR3	55758	broad.mit.edu	37	1	211486235	211486235	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:211486235A>G	uc001hig.2	+	10	1244	c.1075A>G	c.(1075-1077)ACT>GCT	p.T359A	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.T417A|RCOR3_uc010psw.1_Missense_Mutation_p.T417A|RCOR3_uc001hif.2_Intron|RCOR3_uc009xcz.2_RNA	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		TGATGCTTCTACTTTAGGGGA	0.443			NA											64	122					0	0	0.01441	0	0
USH2A	7399	broad.mit.edu	37	1	216166400	216166400	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:216166400G>T	uc001hku.1	-	35	7154	c.6767C>A	c.(6766-6768)TCC>TAC	p.S2256Y		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2256	Fibronectin type-III 9.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACATTAAAGGAGTCAGGTGA	0.473			NA								HNSCC(13;0.011)	OREG0014251	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	319	364					6.11876e-135	1.79844e-134	0.01441	1	0
USH2A	7399	broad.mit.edu	37	1	216497666	216497666	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:216497666C>A	uc001hku.1	-	7	1559	c.1172G>T	c.(1171-1173)AGT>ATT	p.S391I	USH2A_uc001hkv.2_Missense_Mutation_p.S391I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	391	Laminin N-terminal.|Extracellular (Potential).		S -> I (in USH2A; uncertain pathogenicity).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTTGTGGACTAAAGAACTG	0.318			NA								HNSCC(13;0.011)			11	48					2.80697e-09	5.09662e-09	0.010729	1	0
ZNF678	339500	broad.mit.edu	37	1	227838768	227838768	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:227838768G>T	uc001hqw.1	+	3	421	c.76G>T	c.(76-78)GTT>TTT	p.V26F	ZNF678_uc009xet.1_RNA|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	81					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				ttataaactggtttatacagg	0.01			NA											133	288					2.44662e-51	6.64082e-51	0.01441	1	0
TRIM11	81559	broad.mit.edu	37	1	228582544	228582544	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:228582544C>A	uc001hss.2	-	6	1524	c.1269G>T	c.(1267-1269)GGG>GGT	p.G423G	TRIM11_uc010pvx.1_Silent_p.G422G	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	423	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				ATAGCAGTGACCCATCGGTGG	0.632			NA											56	69					5.22555e-25	1.16806e-24	0.01441	1	0
TRIM17	51127	broad.mit.edu	37	1	228602468	228602468	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:228602468G>T	uc001hsu.2	-	2	691	c.306C>A	c.(304-306)CAC>CAA	p.H102Q	TRIM17_uc001hsv.2_Missense_Mutation_p.H102Q|TRIM17_uc001hsw.2_Missense_Mutation_p.H75Q|TRIM17_uc009xfb.2_Missense_Mutation_p.H102Q	NM_016102	NP_057186	Q9Y577	TRI17_HUMAN	tripartite motif-containing 17 isoform 1	102	B box-type.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Prostate(94;0.0724)				GGGGCTCGTGGTGCTCCTGGC	0.662			NA											76	105					8.2577e-42	2.14297e-41	0.01441	1	0
OR13G1	441933	broad.mit.edu	37	1	247836209	247836209	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:247836209G>A	uc001idi.1	-	1	135	c.135C>T	c.(133-135)GCC>GCT	p.A45A		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	45	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TATAGATTTTGGCAATGATGA	0.438			NA											40	50					0	0	0.00874	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285441	248285441	+	Missense_Mutation	SNP	G	G	T	rs6587422	by1000genomes	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:248285441G>T	uc001idy.1	+	1	4	c.4G>T	c.(4-6)GAC>TAC	p.D2Y		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						GTCCCCCATGGACGTCAGGCT	0.522			NA											194	327					1.52457e-88	4.40799e-88	0.01441	1	0
OR2T11	127077	broad.mit.edu	37	1	248790195	248790195	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:248790195G>A	uc001ier.1	-	1	235	c.235C>T	c.(235-237)CTG>TTG	p.L79L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGTCTGCCAGGAGTTTTGGG	0.493			NA											46	34					0	0	0.013114	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256130	15256130	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:15256130C>A	uc001iob.2	-	8	1464	c.1457G>T	c.(1456-1458)AGG>ATG	p.R486M		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	486	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GTAACTACCCCTGTAGTCATC	0.478			NA											41	125					2.95478e-19	6.33847e-19	0.00874	1	0
CUBN	8029	broad.mit.edu	37	10	16975228	16975228	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:16975228C>A	uc001ioo.2	-	40	6034	c.5982G>T	c.(5980-5982)CCG>CCT	p.P1994P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1994	CUB 14.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGGCCAGCCCGGGGAGAAGA	0.507			NA											25	72					1.26454e-06	2.19849e-06	0.005443	1	0
GPR158	57512	broad.mit.edu	37	10	25887469	25887469	+	Nonsense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:25887469A>T	uc001isj.2	+	11	2974	c.2914A>T	c.(2914-2916)AAA>TAA	p.K972*	GPR158_uc001isk.2_Nonsense_Mutation_p.K347*	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	972	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAAGCCTCAGAAATCTGGGAT	0.463			NA											40	150					0	0	0.00874	0	0
GAD2	2572	broad.mit.edu	37	10	26581399	26581399	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:26581399T>A	uc001isp.2	+	14	1895	c.1392T>A	c.(1390-1392)ACT>ACA	p.T464T	GAD2_uc001isq.2_Silent_p.T464T	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	464					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CCTAGGGGACTACCGGGTTTG	0.463			NA											16	65					0	0	0.004007	0	0
MTPAP	55149	broad.mit.edu	37	10	30615475	30615475	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:30615475C>G	uc001iva.3	-	5	933	c.870G>C	c.(868-870)GAG>GAC	p.E290D	MTPAP_uc001ivb.3_Missense_Mutation_p.E420D	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	290					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						GGTCAAGGCACTCTCCTAACA	0.443			NA											125	169					0	0	0.01441	0	0
ENTPD7	57089	broad.mit.edu	37	10	101439629	101439629	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:101439629A>T	uc001kqa.3	+	5	723	c.545A>T	c.(544-546)GAG>GTG	p.E182V	ENTPD7_uc009xwl.2_Missense_Mutation_p.E184V	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	182	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CTTCTCCCTGAGAGGTGAGAT	0.537			NA											55	100					0	0	0.01441	0	0
LZTS2	84445	broad.mit.edu	37	10	102763434	102763434	+	Silent	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:102763434C>G	uc001ksj.2	+	3	648	c.579C>G	c.(577-579)TCC>TCG	p.S193S	LZTS2_uc010qpw.1_Silent_p.S193S|LZTS2_uc001ksk.2_Silent_p.S193S|LZTS2_uc001ksl.2_Silent_p.S193S|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	193	Ser-rich.|Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		cctcctcttcctcctcctctt	0.547	Esophageal Squamous(8;38 437 13604 19902 37640)		NA											78	365					0	0	0.01441	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202577	118202577	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:118202577C>A	uc001lcl.3	+	3	316	c.215C>A	c.(214-216)GCG>GAG	p.A72E		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	72					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		GAGATCAGTGCGGTTAATTCT	0.363			NA											10	16					0.000442599	0.000735821	0.006214	1	0
KCNK18	338567	broad.mit.edu	37	10	118969418	118969418	+	Nonsense_Mutation	SNP	G	G	T	rs3026042		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:118969418G>T	uc010qsr.1	+	3	763	c.763G>T	c.(763-765)GAA>TAA	p.E255*		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	255	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CTCGTGTCCCGAACTGGTGTT	0.532			NA											68	109					2.36135e-34	5.78913e-34	0.01441	1	0
CPXM2	119587	broad.mit.edu	37	10	125526525	125526525	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:125526525A>G	uc001lhk.1	-	10	1768	c.1443T>C	c.(1441-1443)ATT>ATC	p.I481I	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	481					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CAGGGATTGCAATATAGTGAT	0.453			NA											57	98					0	0	0.01441	0	0
DOCK1	1793	broad.mit.edu	37	10	128925932	128925932	+	Splice_Site	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:128925932G>T	uc001ljt.2	+	27	2753	c.2689_splice	c.e27-1	p.G897_splice	DOCK1_uc010qun.1_Splice_Site_p.G918_splice	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1						apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TCCTTCCCCAGGGGCCAACCC	0.473			NA											26	80					2.48779e-11	4.72681e-11	0.005443	1	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642979	1642979	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:1642979C>A	uc009ycy.1	-	3	570	c.483G>T	c.(481-483)GGG>GGT	p.G161G		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	175	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCTTGGAACCCCCACAGGAGC	0.662			NA											72	103					3.53432e-41	9.08338e-41	0.01441	1	0
OR51F1	256892	broad.mit.edu	37	11	4790612	4790612	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:4790612G>A	uc010qyl.1	-	1	536	c.536C>T	c.(535-537)TCC>TTC	p.S179F		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	179						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GTAACAATAGGAGTGAGAAAG	0.393			NA											44	68					0	0	0.011902	0	0
OR2AG2	338755	broad.mit.edu	37	11	6790080	6790080	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:6790080A>T	uc001meq.1	-	1	109	c.109T>A	c.(109-111)TTG>ATG	p.L37M		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GTCAGTGCCAACATGTATAGG	0.537			NA											61	84					0	0	0.01441	0	0
SPON1	10418	broad.mit.edu	37	11	14063147	14063148	+	Missense_Mutation	DNP	GG	GG	CC			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:14063147_14063148GG>CC	uc001mle.2	+	3	963_964	c.425_426GG>CC	c.(424-426)CGG>CCC	p.R142P		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	142	Reelin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		AGGAGGACCCGGATCCAGGTGT	0.475			NA											93	133					0	0	0.004672	0	0
INSC	387755	broad.mit.edu	37	11	15134022	15134022	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:15134022C>A	uc001mly.2	+	1	53	c.7C>A	c.(7-9)CGG>AGG	p.R3R	INSC_uc001mlz.2_5'Flank	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	3					cell differentiation|nervous system development	cytoplasm	binding	p.R3W(1)		upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						AGCCATGAGACGGCCCCCTGG	0.627			NA											40	48					1.02591e-13	2.01395e-13	0.010771	1	0
OR4A15	81328	broad.mit.edu	37	11	55136137	55136137	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:55136137G>T	uc010rif.1	+	1	778	c.778G>T	c.(778-780)GGG>TGG	p.G260W		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	260	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGTTTGGAAGGGAAACGAAA	0.428			NA											97	107					2.42943e-58	6.73156e-58	0.01441	1	0
OR10Q1	219960	broad.mit.edu	37	11	57996156	57996156	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:57996156A>G	uc010rkd.1	-	1	192	c.192T>C	c.(190-192)TAT>TAC	p.Y64Y		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				ACAGGAAGAAATACATCGGGG	0.527			NA											26	96					0	0	0.005443	0	0
AHNAK	79026	broad.mit.edu	37	11	62292534	62292534	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:62292534C>T	uc001ntl.2	-	5	9655	c.9355G>A	c.(9355-9357)GAC>AAC	p.D3119N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3119					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACTTTCATGTCACCTTCCACT	0.478			NA											47	564					0	0	0.01441	0	0
SLC22A25	387601	broad.mit.edu	37	11	62932091	62932091	+	Missense_Mutation	SNP	C	C	T	rs148517822	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:62932091C>T	uc001nwr.1	-	8	1301	c.1301G>A	c.(1300-1302)CGT>CAT	p.R434H	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	434	Extracellular (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CAAAACCACACGCAGGGTCTG	0.478			NA											41	47					0	0	0.007835	0	0
RTN3	10313	broad.mit.edu	37	11	63449190	63449190	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:63449190G>T	uc001nxq.2	+	1	269	c.82G>T	c.(82-84)GGC>TGC	p.G28C	RTN3_uc001nxo.2_Missense_Mutation_p.G28C|RTN3_uc001nxm.2_Missense_Mutation_p.G28C|RTN3_uc001nxn.2_Missense_Mutation_p.G28C|RTN3_uc001nxp.2_Missense_Mutation_p.G28C|RTN3_uc009yov.2_Missense_Mutation_p.G28C|RTN3_uc010rmt.1_RNA|RTN3_uc010rmu.1_Missense_Mutation_p.G28C	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	28					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						GCCCGGCGGCGGCGGGAGCCC	0.746			NA											12	13					1.15088e-07	2.03411e-07	0.004007	1	0
MOGAT2	80168	broad.mit.edu	37	11	75438556	75438556	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:75438556G>T	uc010rru.1	+	3	347	c.347G>T	c.(346-348)GGA>GTA	p.G116V	MOGAT2_uc001oww.1_Missense_Mutation_p.G116V|MOGAT2_uc010rrv.1_Missense_Mutation_p.G34V	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	116	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					CTGGCAGTCGGAGCCTTTGCC	0.607			NA											33	92					5.8336e-16	1.2029e-15	0.003271	1	0
OR10G4	390264	broad.mit.edu	37	11	123886668	123886668	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:123886668C>A	uc010sac.1	+	1	387	c.387C>A	c.(385-387)CTC>CTA	p.L129L		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTTACCCGCTCAGGTACACCA	0.552			NA											51	239					6.2918e-36	1.56413e-35	0.01441	1	0
OR10G7	390265	broad.mit.edu	37	11	123908791	123908791	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:123908791T>C	uc001pzq.1	-	1	918	c.918A>G	c.(916-918)GTA>GTG	p.V306V		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CCTGAGCAAATACTGACCCAT	0.353			NA											36	47					0	0	0.00623	0	0
FOXM1	2305	broad.mit.edu	37	12	2975569	2975569	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:2975569T>A	uc001qlf.2	-	5	1230	c.965A>T	c.(964-966)CAG>CTG	p.Q322L	FOXM1_uc001qle.2_Missense_Mutation_p.Q322L|FOXM1_uc001qlg.2_Missense_Mutation_p.Q322L|FOXM1_uc009zea.2_Missense_Mutation_p.Q321L|FOXM1_uc009zeb.2_Missense_Mutation_p.Q321L	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	322	Fork-head.				cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CTTAAACACCTGGTCCAATGT	0.498			NA											79	92					0	0	0.01441	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	25					1.5739e-10	2.91747e-10	0.004007	1	0
MLL2	8085	broad.mit.edu	37	12	49445287	49445287	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:49445287G>A	uc001rta.3	-	10	2179	c.2179C>T	c.(2179-2181)CCA>TCA	p.P727S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	727	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAGGTAGTGGCAACAGGGGT	0.692			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			59	113					0	0	0.01441	0	0
SP1	6667	broad.mit.edu	37	12	53800380	53800380	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:53800380G>T	uc001scw.2	+	4	1784	c.1687G>T	c.(1687-1689)GCT>TCT	p.A563S	SP1_uc010sog.1_Missense_Mutation_p.A556S	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	563	Transactivation domain C (highly charged).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		TGATCATGGAGCTCAGCTTGG	0.502			NA											60	94					6.60958e-23	1.45301e-22	0.01441	1	0
TARBP2	6895	broad.mit.edu	37	12	53899526	53899526	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:53899526C>A	uc001sdo.2	+	8	1323	c.835C>A	c.(835-837)CTC>ATC	p.L279I	TARBP2_uc001sdp.2_Missense_Mutation_p.L258I|TARBP2_uc001sdq.2_Missense_Mutation_p.L135I|TARBP2_uc001sdr.2_Missense_Mutation_p.L135I|TARBP2_uc001sds.2_Missense_Mutation_p.P236H|TARBP2_uc001sdt.2_Missense_Mutation_p.L258I|TARBP2_uc001sdu.2_Missense_Mutation_p.L135I|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	279	Sufficient for interaction with DICER1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						GATCCTGTCCCTCCGCAGTTG	0.617			NA											8	297					0.00307968	0.00507241	0.00308	1	0
OR6C1	390321	broad.mit.edu	37	12	55714896	55714896	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:55714896T>A	uc010spi.1	+	1	513	c.513T>A	c.(511-513)ATT>ATA	p.I171I		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						GGTCTAATATTATTGACCATT	0.373			NA											31	78					0	0	0.009535	0	0
PTPRB	5787	broad.mit.edu	37	12	70956688	70956688	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:70956688G>T	uc001swb.3	-	14	3480	c.3450C>A	c.(3448-3450)TAC>TAA	p.Y1150*	PTPRB_uc010sto.1_Nonsense_Mutation_p.Y1060*|PTPRB_uc010stp.1_Nonsense_Mutation_p.Y1060*|PTPRB_uc001swc.3_Nonsense_Mutation_p.Y1368*|PTPRB_uc001swa.3_Nonsense_Mutation_p.Y1280*|PTPRB_uc001swd.3_Nonsense_Mutation_p.Y1367*|PTPRB_uc009zrr.1_Nonsense_Mutation_p.Y1247*	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1150	Fibronectin type-III 13.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCACCATCTTGTACATTCTGC	0.453			NA											58	115					5.19286e-32	1.26146e-31	0.01441	1	0
NAV3	89795	broad.mit.edu	37	12	78225190	78225190	+	Translation_Start_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:78225190C>A	uc001syp.2	+	1	122	c.-51C>A	c.(-53--49)GACTG>GAATG		NAV3_uc001syo.2_Translation_Start_Site	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GTCTACCAGACTGAGGTTAGA	0.373			NA								HNSCC(70;0.22)			194	376					4.36549e-90	1.26909e-89	0.01441	1	0
SLC6A15	55117	broad.mit.edu	37	12	85279240	85279240	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:85279240G>T	uc001szv.2	-	4	1041	c.548C>A	c.(547-549)CCT>CAT	p.P183H	SLC6A15_uc010sul.1_Missense_Mutation_p.P76H|SLC6A15_uc001szy.2_Missense_Mutation_p.P183H	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	183	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						TTTCACCAAAGGACACTGATC	0.373			NA											56	90					6.3091e-27	1.44674e-26	0.01441	1	0
MGAT4C	25834	broad.mit.edu	37	12	86373526	86373526	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:86373526C>A	uc001tai.3	-	8	2228	c.978G>T	c.(976-978)AAG>AAT	p.K326N	MGAT4C_uc001tal.3_Missense_Mutation_p.K326N|MGAT4C_uc001taj.3_Missense_Mutation_p.K326N|MGAT4C_uc001tak.3_Missense_Mutation_p.K326N|MGAT4C_uc010sum.1_Missense_Mutation_p.K350N|MGAT4C_uc001tah.3_Missense_Mutation_p.K326N	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	326	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						AATCATCATCCTTCAGCTTAT	0.408			NA											33	68					4.74835e-14	9.46114e-14	0.010818	1	0
NR1H4	9971	broad.mit.edu	37	12	100904815	100904815	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:100904815C>A	uc001tht.1	+	2	397	c.369C>A	c.(367-369)CGC>CGA	p.R123R	NR1H4_uc001thp.1_Silent_p.R113R|NR1H4_uc001thq.1_Silent_p.R113R|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.R113R|NR1H4_uc010svk.1_Silent_p.R113R|NR1H4_uc001ths.1_Silent_p.R123R	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	123					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AGAAGCCCCGCATGGGCGCGT	0.527			NA											53	122					2.48254e-18	5.28285e-18	0.01441	1	0
STAB2	55576	broad.mit.edu	37	12	104133198	104133198	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:104133198T>C	uc001tjw.2	+	54	5892	c.5706T>C	c.(5704-5706)TGT>TGC	p.C1902C	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1902	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGGGGGAGTGTGGGAGCTGTG	0.413			NA											16	114					0	0	0.004007	0	0
ACACB	32	broad.mit.edu	37	12	109577847	109577847	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:109577847C>T	uc001tob.2	+	2	756	c.637C>T	c.(637-639)CGC>TGC	p.R213C	ACACB_uc001toc.2_Missense_Mutation_p.R213C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	213					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	AGCTGAGACCCGCGTCCCCAC	0.587			NA											42	86					0	0	0.011902	0	0
CAMKK2	10645	broad.mit.edu	37	12	121701685	121701685	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:121701685C>A	uc001tzu.2	-	6	807	c.683G>T	c.(682-684)GGC>GTC	p.G228V	CAMKK2_uc001tzt.2_Missense_Mutation_p.G228V|CAMKK2_uc001tzv.2_Missense_Mutation_p.G228V|CAMKK2_uc001tzw.2_Missense_Mutation_p.G228V|CAMKK2_uc001tzx.2_Missense_Mutation_p.G228V|CAMKK2_uc001tzy.2_Missense_Mutation_p.G228V|CAMKK2_uc001uaa.1_Missense_Mutation_p.G228V|CAMKK2_uc001uab.2_Missense_Mutation_p.G228V|CAMKK2_uc001uac.2_Missense_Mutation_p.G228V	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	228	Protein kinase.				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CTCAATGGGGCCCCTGGGCTG	0.607			NA											34	49					1.22384e-17	2.57344e-17	0.013726	1	0
WDR66	144406	broad.mit.edu	37	12	122396894	122396894	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:122396894T>C	uc009zxk.2	+	13	2169	c.2027T>C	c.(2026-2028)CTT>CCT	p.L676P		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	676	WD 7.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GTTTACATTCTTGATGCAATG	0.388	Esophageal Squamous(85;849 1794 49757 52143)		NA											60	118					0	0	0.01441	0	0
PSPC1	55269	broad.mit.edu	37	13	20283715	20283715	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:20283715C>A	uc001uml.2	-	7	1369	c.1183G>T	c.(1183-1185)GAT>TAT	p.D395Y	PSPC1_uc001umj.1_Intron|PSPC1_uc001umk.1_Intron	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	395	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		GGACCCATATCACCCATTCTC	0.383			NA											113	56					1.46925e-46	3.94767e-46	0.01441	1	0
TRPC4	7223	broad.mit.edu	37	13	38266181	38266181	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:38266181G>T	uc001uws.2	-	4	1424	c.1189C>A	c.(1189-1191)CCA>ACA	p.P397T	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.P397T|TRPC4_uc010tey.1_Missense_Mutation_p.P397T|TRPC4_uc010abw.2_Missense_Mutation_p.P224T|TRPC4_uc010abx.2_Missense_Mutation_p.P397T|TRPC4_uc010aby.2_Missense_Mutation_p.P397T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	397	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTTGGTGGTGGACCTTGCCTG	0.438			NA											91	48					6.00224e-42	1.56529e-41	0.01441	1	0
PCDH17	27253	broad.mit.edu	37	13	58207981	58207981	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:58207981C>T	uc001vhq.1	+	1	2193	c.1301C>T	c.(1300-1302)ACA>ATA	p.T434I	PCDH17_uc010aec.1_Missense_Mutation_p.T434I	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	434	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GACCGCGAGACACAAGACGAG	0.517	Melanoma(72;952 1291 1619 12849 33676)		NA											19	73					0	0	0.014323	0	0
RNF219	79596	broad.mit.edu	37	13	79189773	79189773	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:79189773T>C	uc001vkw.1	-	6	2182	c.2123A>G	c.(2122-2124)AAA>AGA	p.K708R	uc001vku.1_Intron|RNF219_uc010afb.1_Missense_Mutation_p.K518R|RNF219_uc010afc.2_3'UTR	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	708	Ser-rich.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GATTTTTCTTTTTGTTGATTG	0.403			NA											46	196					0	0	0.01441	0	0
PCCA	5095	broad.mit.edu	37	13	100953772	100953772	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:100953772G>C	uc001voo.2	+	13	1162	c.1124G>C	c.(1123-1125)CGT>CCT	p.R375P	PCCA_uc010aga.2_Missense_Mutation_p.R349P|PCCA_uc010tiz.1_Missense_Mutation_p.R375P|PCCA_uc001vop.2_RNA	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	375	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	GAAATGATCCGTGTTGCTAAG	0.502			NA											47	212					0	0	0.01441	0	0
CPNE6	9362	broad.mit.edu	37	14	24546540	24546540	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr14:24546540C>A	uc001wll.2	+	15	1576	c.1477C>A	c.(1477-1479)CGA>AGA	p.R493R	CPNE6_uc010tnv.1_Silent_p.R548R|CPNE6_uc001wlm.2_Silent_p.R318R|CPNE6_uc001wln.2_Silent_p.R161R	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	493	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		GCGCTGCCCCCGAGGGGTGCC	0.647			NA											57	30					1.3268e-25	2.99093e-25	0.01441	1	0
CCDC88C	440193	broad.mit.edu	37	14	91770243	91770243	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr14:91770243T>C	uc010aty.2	-	20	3536	c.3437A>G	c.(3436-3438)AAG>AGG	p.K1146R		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1146	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CTCCGTCTCCTTGGCCGTGTG	0.652			NA											68	38					0	0	0.01441	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409967	105409967	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr14:105409967G>A	uc010axc.1	-	7	11941	c.11821C>T	c.(11821-11823)CCA>TCA	p.P3941S	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3841S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3941						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGGCTCCTGGGGCCTCGACG	0.602			NA											224	138					0	0	0.01441	0	0
BCL8	606	broad.mit.edu	37	15	20876518	20876518	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:20876518C>G	uc010tze.1	-	2	302	c.95G>C	c.(94-96)GGA>GCA	p.G32A	BCL8_uc010tzd.1_RNA	NR_027992				RecName: Full=Putative protein BCL8;												0						CAAAGGTACTCCATGAGATAA	0.338			NA											28	203					0	0	0.005443	0	0
GOLGA8E	390535	broad.mit.edu	37	15	23444033	23444033	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:23444033G>A	uc001yvu.2	+	14	1677	c.688G>A	c.(688-690)GAG>AAG	p.E230K		NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E											skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;5.21e-07)|Epithelial(43;5.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.000614)		TCTGGACAGTGAGGGGGAGGA	0.627			NA											15	196					0	0	0.010504	0	0
ACTC1	70	broad.mit.edu	37	15	35086900	35086900	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:35086900A>G	uc001ziu.1	-	2	353	c.110T>C	c.(109-111)GTG>GCG	p.V37A	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	37					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CGGGCGGCCCACGATGGACGG	0.687			NA											36	47					0	0	0.003271	0	0
INO80	54617	broad.mit.edu	37	15	41361779	41361779	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:41361779G>C	uc001zni.2	-	14	1984	c.1771C>G	c.(1771-1773)CCT>GCT	p.P591A	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	591	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.|Helicase ATP-binding.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TTAAATTTAGGAACAAATCTA	0.348			NA											25	31					0	0	0.004656	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43663583	43663583	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:43663583G>A	uc001zro.2	+	1	271	c.31G>A	c.(31-33)GGG>AGG	p.G11R	ZSCAN29_uc001zrj.1_5'Flank|ZSCAN29_uc001zrk.1_5'Flank|ZSCAN29_uc010bdf.1_5'Flank|ZSCAN29_uc001zrl.1_5'Flank|ZSCAN29_uc010bdg.1_5'Flank|ZSCAN29_uc001zrm.2_5'Flank|TUBGCP4_uc001zrn.2_Missense_Mutation_p.G11R	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	11					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		GGCTCTGAGCGGGTACCCTGG	0.652			NA									OREG0023087	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	45					0	0	0.007291	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152668	50152668	+	Missense_Mutation	SNP	C	C	A	rs142334062		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:50152668C>A	uc001zxu.2	-	28	3444	c.3302G>T	c.(3301-3303)CGC>CTC	p.R1101L	ATP8B4_uc010ber.2_Missense_Mutation_p.R974L|ATP8B4_uc010ufd.1_Missense_Mutation_p.R911L|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Missense_Mutation_p.R104L	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1101	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTGCCACCGGCGGATCTGGAG	0.498			NA											30	121					3.1745e-13	6.1862e-13	0.008361	1	0
ATP8B4	79895	broad.mit.edu	37	15	50152670	50152670	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:50152670G>A	uc001zxu.2	-	28	3442	c.3300C>T	c.(3298-3300)ATC>ATT	p.I1100I	ATP8B4_uc010ber.2_Silent_p.I973I|ATP8B4_uc010ufd.1_Silent_p.I910I|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Silent_p.I103I	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1100	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GCCACCGGCGGATCTGGAGAG	0.498			NA											30	119					0	0	0.00632	0	0
IGDCC4	57722	broad.mit.edu	37	15	65677380	65677380	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:65677380G>T	uc002aou.1	-	19	3464	c.3254C>A	c.(3253-3255)CCC>CAC	p.P1085H	IGDCC4_uc002aot.1_Missense_Mutation_p.P673H	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1085	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						AGCCGGCCGGGGGCCTGCCTG	0.672			NA									OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	57					2.5808e-16	5.36322e-16	0.006122	1	0
ALPK3	57538	broad.mit.edu	37	15	85401453	85401453	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:85401453G>C	uc002ble.2	+	6	4257	c.4090G>C	c.(4090-4092)GGG>CGG	p.G1364R		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1364			G -> E (in a metastatic melanoma sample; somatic mutation).		heart development	nucleus	ATP binding|protein serine/threonine kinase activity	p.G1364E(1)		stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACTGGCTCTAGGGGCCCGGAG	0.627			NA											11	18					0	0	0.013537	0	0
BLM	641	broad.mit.edu	37	15	91341491	91341491	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:91341491A>G	uc002bpr.2	+	17	3379	c.3282A>G	c.(3280-3282)TCA>TCG	p.S1094S	BLM_uc010uqh.1_Silent_p.S1094S|BLM_uc010uqi.1_Silent_p.S719S|BLM_uc010bnx.2_Silent_p.S1094S|BLM_uc002bpt.2_Silent_p.S69S	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1094					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			ATAGTTCATCACAAGGAATGA	0.318			NA	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				62	79					0	0	0.01441	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395019	1395019	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:1395019C>T	uc002clk.1	+	21	1964	c.1964C>T	c.(1963-1965)ACC>ATC	p.T655I	BAIAP3_uc002clj.2_Missense_Mutation_p.T637I|BAIAP3_uc010uuz.1_Missense_Mutation_p.T620I|BAIAP3_uc010uva.1_Missense_Mutation_p.T592I|BAIAP3_uc010uvc.1_Missense_Mutation_p.T584I	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	655					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				CCCAAGATGACCCTGGAGGTG	0.657			NA											41	54					0	0	0.00874	0	0
MLST8	64223	broad.mit.edu	37	16	2256104	2256104	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:2256104C>A	uc002coz.2	+	2	137	c.18C>A	c.(16-18)GGC>GGA	p.G6G	MLST8_uc002coy.2_Silent_p.G6G|MLST8_uc002cpa.2_5'UTR|MLST8_uc002cpb.2_Silent_p.G6G|MLST8_uc010uvx.1_5'UTR|MLST8_uc002cpc.2_Silent_p.G6G|MLST8_uc002cpd.2_5'UTR|MLST8_uc002cpe.2_Silent_p.G6G|MLST8_uc010uvy.1_Silent_p.G6G|MLST8_uc002cpg.2_Silent_p.G25G|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Silent_p.G6G	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	6	WD 1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						CCTCCCCAGGCACGGTGGGCA	0.632			NA											13	203					1.15088e-07	2.03411e-07	0.004007	1	0
TIGD7	91151	broad.mit.edu	37	16	3349590	3349590	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:3349590T>C	uc002cus.2	-	1	1811	c.1025A>G	c.(1024-1026)TAT>TGT	p.Y342C	ZNF263_uc002cur.2_3'UTR	NM_033208	NP_149985	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	342	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CTTCCATCTATACAGCCGTTT	0.264			NA											30	95					0	0	0.007291	0	0
DNAJA3	9093	broad.mit.edu	37	16	4494686	4494686	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:4494686T>A	uc002cwk.2	+	7	978	c.953T>A	c.(952-954)GTG>GAG	p.V318E	DNAJA3_uc002cwl.2_Missense_Mutation_p.V318E|DNAJA3_uc010uxk.1_Missense_Mutation_p.V165E	NM_005147	NP_005138	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	318					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			ovary(2)|breast(2)	4						GGCCAGACCGTGAGGATGCCT	0.403			NA											13	55					0	0	0.00245	0	0
EEF2K	29904	broad.mit.edu	37	16	22262545	22262545	+	Nonsense_Mutation	SNP	G	G	T	rs148576611		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:22262545G>T	uc002dki.2	+	6	1005	c.520G>T	c.(520-522)GAG>TAG	p.E174*	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	174	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		GCGCTACATCGAGCCCGTAGA	0.592	NSCLC(195;1411 2157 20319 27471 51856)		NA											29	145					7.26314e-15	1.4692e-14	0.007291	1	0
PALB2	79728	broad.mit.edu	37	16	23632700	23632700	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:23632700C>A	uc002dlx.1	-	10	3296	c.3096G>T	c.(3094-3096)ATG>ATT	p.M1032I		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	1032	Interaction with RAD51 and BRCA2.|WD 4.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		CAATGTTGTTCATAATAGTAG	0.234			NA	F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				13	73					1.5739e-10	2.91747e-10	0.004007	1	0
ZNF646	9726	broad.mit.edu	37	16	31087950	31087950	+	Missense_Mutation	SNP	G	G	T	rs143373931	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:31087950G>T	uc002eap.2	+	2	594	c.305G>T	c.(304-306)CGC>CTC	p.R102L	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CCTGAGGGCCGCCGCAGGCAC	0.612			NA											24	65					6.21321e-17	1.29625e-16	0.00278	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32891042	32891042	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:32891042C>A	uc002edh.1	-	3	189	c.13_splice	c.e3-1	p.G5_splice	SLC6A10P_uc002edi.1_Splice_Site					RecName: Full=Transporter;												0						ACATCCCACCCTGGGGGACAG	0.602			NA											68	77					2.40982e-25	5.40938e-25	0.01441	1	0
CES7	221223	broad.mit.edu	37	16	55903558	55903558	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:55903558G>T	uc002eip.2	-	4	665	c.516C>A	c.(514-516)GTC>GTA	p.V172V	CES7_uc002eio.2_Silent_p.V172V|CES7_uc002eiq.2_5'UTR|CES7_uc002eir.2_Silent_p.V66V	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	172						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		GGTACTGGACGACCACAACCA	0.547			NA											30	34					5.8336e-16	1.2029e-15	0.003271	1	0
NLRC5	84166	broad.mit.edu	37	16	57111271	57111271	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:57111271G>T	uc002ekk.1	+	41	5124	c.4899G>T	c.(4897-4899)CTG>CTT	p.L1633L	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Silent_p.L175L|NLRC5_uc002ekr.1_Silent_p.L520L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1633	LRR 21.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				TGCCTGGGCTGCCAGAGCTCA	0.582			NA											29	51					1.06801e-11	2.0365e-11	0.009535	1	0
DPEP2	64174	broad.mit.edu	37	16	68024723	68024723	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:68024723C>A	uc010cey.2	-	6	1073	c.909_splice	c.e6+1	p.L303_splice	DPEP2_uc002evd.3_Splice_Site_p.L303_splice|DPEP2_uc002eve.2_Splice_Site_p.L303_splice|DPEP2_uc002evf.2_Splice_Site	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor						hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CAGTTTCTCACCAGAAGCTGC	0.443			NA											171	188					9.33601e-71	2.65602e-70	0.01441	1	0
CHST6	4166	broad.mit.edu	37	16	75513122	75513122	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:75513122C>A	uc002fef.2	-	3	785	c.605G>T	c.(604-606)CGC>CTC	p.R202L	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R202L	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	202	PAPS (By similarity).|Lumenal (Potential).		R -> S (in MCD).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CCGCGGGTCGCGCACCAGGTG	0.687			NA											46	58					8.01111e-26	1.81358e-25	0.010771	1	0
POLR2A	5430	broad.mit.edu	37	17	7406556	7406556	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:7406556G>C	uc002ghf.3	+	17	3107	c.2873G>C	c.(2872-2874)CGG>CCG	p.R958P		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	958					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GAATTTGAGCGGATGCGGGAG	0.602			NA											30	83					0	0	0.010818	0	0
NOS2	4843	broad.mit.edu	37	17	26114788	26114788	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:26114788C>G	uc002gzu.2	-	5	647	c.383G>C	c.(382-384)GGA>GCA	p.G128A	NOS2_uc010crh.1_Missense_Mutation_p.G128A|NOS2_uc010wab.1_Missense_Mutation_p.G128A	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	128					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTCCCTGGGTCCTCTGGTCAA	0.498			NA											138	150					0	0	0.01441	0	0
KRT37	8688	broad.mit.edu	37	17	39578346	39578346	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:39578346A>T	uc002hwp.1	-	5	1042	c.995T>A	c.(994-996)GTG>GAG	p.V332E	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	332	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				TTGGCGCTCCACCTCCAGGGC	0.582			NA											32	126					0	0	0.003271	0	0
KRT37	8688	broad.mit.edu	37	17	39580632	39580632	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:39580632G>T	uc002hwp.1	-	1	191	c.144C>A	c.(142-144)AAC>AAA	p.N48K	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	48	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CGTGTGCCACGTTGGCCAAGA	0.617			NA											31	83					1.39806e-14	2.81729e-14	0.008361	1	0
ABI3	51225	broad.mit.edu	37	17	47299962	47299962	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:47299962T>A	uc002iop.1	+	8	1484	c.986T>A	c.(985-987)TTC>TAC	p.F329Y	ABI3_uc002ioq.1_Missense_Mutation_p.F323Y	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	329	SH3.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GAGCTCTCCTTCTCTGAGGGC	0.577			NA								HNSCC(55;0.14)			23	65					0	0	0.014323	0	0
DDX42	11325	broad.mit.edu	37	17	61885106	61885106	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:61885106G>T	uc002jbu.2	+	10	1126	c.869G>T	c.(868-870)GGT>GTT	p.G290V	DDX42_uc002jbv.2_Missense_Mutation_p.G290V|DDX42_uc002jbw.1_Missense_Mutation_p.G26V|DDX42_uc002jbx.2_Missense_Mutation_p.G26V	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	290	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						GCATTAAGTGGTAGAGACATG	0.398			NA											88	124					2.07245e-51	5.65408e-51	0.01441	1	0
SLC39A11	201266	broad.mit.edu	37	17	71027788	71027788	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:71027788C>A	uc002jjb.2	-	4	328	c.213G>T	c.(211-213)GGG>GGT	p.G71G	SLC39A11_uc002jja.2_Silent_p.G71G|SLC39A11_uc002jjc.1_Silent_p.G71G	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	71					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1						CACCGAAGCCCCCAGAGGACG	0.532	NSCLC(95;736 1527 12296 39625 41839)		NA											50	52					1.61863e-15	3.32475e-15	0.01441	1	0
KIF19	124602	broad.mit.edu	37	17	72348161	72348161	+	Silent	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:72348161G>C	uc002jkm.3	+	13	1881	c.1743G>C	c.(1741-1743)TCG>TCC	p.S581S	KIF19_uc002jkl.2_Silent_p.S539S	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	581					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						AGATGCAGTCGCACGCGCTGC	0.711			NA											5	8					0	0	0.001168	0	0
KCTD2	23510	broad.mit.edu	37	17	73055632	73055632	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:73055632C>T	uc002jmp.2	+	4	635	c.568C>T	c.(568-570)CTG>TTG	p.L190L	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	190						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					GTACAGAGTCCTGCAGTGTCA	0.562			NA											16	63					0	0	0.006122	0	0
MGAT5B	146664	broad.mit.edu	37	17	74902107	74902107	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:74902107T>C	uc002jti.2	+	7	999	c.896T>C	c.(895-897)GTC>GCC	p.V299A	MGAT5B_uc002jth.2_Missense_Mutation_p.V288A	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	288	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CAGATCCTGGTCCACATCGGC	0.692			NA											42	88					0	0	0.01441	0	0
SLC38A10	124565	broad.mit.edu	37	17	79225400	79225400	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:79225400G>A	uc002jzz.1	-	14	2333	c.1958C>T	c.(1957-1959)CCC>CTC	p.P653L	SLC38A10_uc002jzy.1_Missense_Mutation_p.P571L|SLC38A10_uc002kab.2_Missense_Mutation_p.P653L	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	653					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGCTGGGAGGGGAGGCTTCCC	0.672			NA											7	31					0	0	0.006214	0	0
C17orf101	79701	broad.mit.edu	37	17	80361813	80361813	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:80361813C>A	uc002keu.1	-	7	800	c.699G>T	c.(697-699)AAG>AAT	p.K233N	C17orf101_uc002ket.1_Missense_Mutation_p.K233N|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	233	Fe2OG dioxygenase.|Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						GCGCGCTCACCTTGTCCACGT	0.677			NA											9	14					1.58986e-06	2.74613e-06	0.008291	1	0
LRRC30	339291	broad.mit.edu	37	18	7231504	7231504	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:7231504T>A	uc010wzk.1	+	1	368	c.368T>A	c.(367-369)TTT>TAT	p.F123Y		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	123	LRR 3.									ovary(1)|liver(1)	2						AAGGTCCTGTTTGTCAACATG	0.597			NA											24	54					0	0	0.014323	0	0
RNMT	8731	broad.mit.edu	37	18	13737009	13737009	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:13737009G>T	uc002ksk.1	+	4	621	c.554G>T	c.(553-555)GGA>GTA	p.G185V	RNMT_uc002ksl.1_Missense_Mutation_p.G185V|RNMT_uc002ksm.1_Missense_Mutation_p.G185V|RNMT_uc010dlk.2_Missense_Mutation_p.G185V|RNMT_uc010xae.1_RNA	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	185					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						TCTCTTTTAGGAGAATTTTTG	0.348	GBM(29;474 594 19092 36647 41529)		NA											21	42					1.96292e-10	3.61341e-10	0.010504	1	0
OSBPL1A	114876	broad.mit.edu	37	18	21747356	21747356	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:21747356T>C	uc002kve.2	-	25	2646	c.2472A>G	c.(2470-2472)GTA>GTG	p.V824V	OSBPL1A_uc002kvd.2_Silent_p.V311V|OSBPL1A_uc010xbc.1_Silent_p.V442V	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	824					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					GGATAATGAATACACTTTCAG	0.463			NA											47	97					0	0	0.01441	0	0
SALL3	27164	broad.mit.edu	37	18	76757146	76757146	+	Missense_Mutation	SNP	G	G	T	rs140437850		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:76757146G>T	uc002lmt.2	+	3	3727	c.3727G>T	c.(3727-3729)GTG>TTG	p.V1243L	SALL3_uc010dra.2_Missense_Mutation_p.V778L	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCAGCTCCCCGTGAGTCTTGG	0.607			NA											42	136					2.37825e-27	5.50099e-27	0.010771	1	0
PTPRS	5802	broad.mit.edu	37	19	5225821	5225821	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:5225821G>C	uc002mbv.2	-	17	2645	c.2411C>G	c.(2410-2412)GCG>GGG	p.A804G	PTPRS_uc002mbu.1_Intron|PTPRS_uc010xin.1_Intron|PTPRS_uc002mbw.2_Missense_Mutation_p.A782G|PTPRS_uc002mbx.2_Intron|PTPRS_uc002mby.2_Intron	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	804	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GATGGAGTACGCGGTCTCAGG	0.647			NA											24	30					0	0	0.00278	0	0
KEAP1	9817	broad.mit.edu	37	19	10602620	10602620	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:10602620G>A	uc002moq.1	-	3	1114	c.958C>T	c.(958-960)CGG>TGG	p.R320W	KEAP1_uc002mop.1_Missense_Mutation_p.R38W|KEAP1_uc002mor.1_Missense_Mutation_p.R320W	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TTGGGCGCCCGGCAGGGCATC	0.642			NA											27	18					0	0	0.005443	0	0
SLC5A5	6528	broad.mit.edu	37	19	18001744	18001744	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:18001744C>A	uc002nhr.3	+	14	2048	c.1701C>A	c.(1699-1701)CTC>CTA	p.L567L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	567	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGTGGGACCTCGCACGGCAGA	0.592	Melanoma(65;1008 1708 7910 46650)		NA											123	61					2.34035e-62	6.55298e-62	0.01441	1	0
LOC284441	284441	broad.mit.edu	37	19	20369339	20369339	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:20369339T>C	uc002nov.2	+	1	883	c.132T>C	c.(130-132)AAT>AAC	p.N44N		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						AGAAACCTAATATAGATACCA	0.373			NA											54	122					0	0	0.01441	0	0
ZNF675	171392	broad.mit.edu	37	19	23836246	23836246	+	Missense_Mutation	SNP	T	T	C	rs147297608		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:23836246T>C	uc002nri.2	-	4	1671	c.1489A>G	c.(1489-1491)ACA>GCA	p.T497A		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	497	C2H2-type 13.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTTTTATGTGTAGTAAGGGAT	0.363			NA											30	24					0	0	0.010818	0	0
ZNF607	84775	broad.mit.edu	37	19	38202555	38202555	+	Translation_Start_Site	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:38202555G>A	uc002ohc.1	-	2	561	c.-35C>T	c.(-37--33)AACGC>AATGC		ZNF607_uc002ohb.1_Translation_Start_Site	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			AGTCCTTGGCGTTTCTCTACC	0.438			NA											15	47					0	0	0.00245	0	0
PSG11	5680	broad.mit.edu	37	19	43519364	43519364	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:43519364G>T	uc002ovm.1	-	4	975	c.868C>A	c.(868-870)CAG>AAG	p.Q290K	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Missense_Mutation_p.Q296K|PSG11_uc002ovo.1_Missense_Mutation_p.Q168K|PSG11_uc002ovp.1_Missense_Mutation_p.Q168K	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	290	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGAGTAATCTGAGGGATAAAG	0.463			NA											73	269					5.32961e-40	1.36315e-39	0.01441	1	0
PSG2	5670	broad.mit.edu	37	19	43579759	43579759	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:43579759G>A	uc002ovr.2	-	3	549	c.456C>T	c.(454-456)TCC>TCT	p.S152S	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.S152S|PSG2_uc010eiq.1_Silent_p.S152S|PSG2_uc002ovs.3_Silent_p.S152S|PSG2_uc002ovt.3_Silent_p.S152S	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	152	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				AGTTGCTGCTGGAGATGGAGG	0.498			NA											78	313					0	0	0.01441	0	0
SEC1	653677	broad.mit.edu	37	19	49183484	49183484	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:49183484G>A	uc010xzv.1	+	5	631	c.504G>A	c.(502-504)CTG>CTA	p.L168L	SEC1_uc002pka.2_Silent_p.L128L|SEC1_uc010xzw.1_Silent_p.L85L|SEC1_uc010ema.2_Silent_p.L74L	NR_004401				SubName: Full=cDNA FLJ58287, highly similar to Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69);												0						AGGGCCGCCTGGGGAACCAGA	0.682			NA											8	11					0	0	0.004482	0	0
KLK3	354	broad.mit.edu	37	19	51361318	51361318	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:51361318G>T	uc002pts.1	+	3	281	c.240G>T	c.(238-240)CTG>CTT	p.L80L	KLK3_uc010ycj.1_Silent_p.L80L|KLK3_uc002ptr.1_Intron|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	80	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GGCACAGCCTGTTTCATCCTG	0.547	Colon(185;1767 2023 13025 30120 37630)		NA											20	55					1.2644e-06	2.19849e-06	0.010504	1	0
LILRA4	23547	broad.mit.edu	37	19	54848199	54848199	+	Missense_Mutation	SNP	C	C	G	rs143168076		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:54848199C>G	uc002qfj.2	-	6	1225	c.1168G>C	c.(1168-1170)GCG>CCG	p.A390P	LILRA4_uc002qfi.2_Missense_Mutation_p.A324P	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	390	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TAGGTCCCCGCGTGGGCTGAG	0.622			NA											115	254					0	0	0.01441	0	0
PTPRH	5794	broad.mit.edu	37	19	55693405	55693406	+	Missense_Mutation	DNP	CC	CC	AA	rs145661468	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:55693405_55693406CC>AA	uc002qjq.2	-	19	3249_3250	c.3176_3177GG>TT	c.(3175-3177)CGG>CTT	p.R1059L	PTPRH_uc010esv.2_Missense_Mutation_p.R881L|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1059	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CCATCAACGGCCGACTCTCTCT	0.634			NA											73	100					0	0	0.004672	0	0
NLRP11	204801	broad.mit.edu	37	19	56300690	56300690	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:56300690C>A	uc010ygf.1	-	10	3300	c.2589G>T	c.(2587-2589)AGG>AGT	p.R863S	NLRP11_uc002qlz.2_Missense_Mutation_p.R710S|NLRP11_uc002qmb.2_Missense_Mutation_p.R764S|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	863	LRR 5.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TCTCCAGGCTCCTCAGTTTTT	0.423			NA											96	116					1.43847e-43	3.82632e-43	0.01441	1	0
NLRP5	126206	broad.mit.edu	37	19	56572869	56572869	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:56572869A>G	uc002qmj.2	+	15	3578	c.3578A>G	c.(3577-3579)GAT>GGT	p.D1193G	NLRP5_uc002qmi.2_Missense_Mutation_p.D1174G	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	1193						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTTGATGAAGATGACCGGTAC	0.478			NA											36	147					0	0	0.004289	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010492	59010492	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:59010492G>T	uc002qtc.2	-	8	1873	c.1763C>A	c.(1762-1764)CCA>CAA	p.P588Q	SLC27A5_uc002qtb.2_RNA	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	588	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CTCCGCACCTGGCACGCACAC	0.343			NA											39	49					2.35958e-20	5.12367e-20	0.009718	1	0
MYT1L	23040	broad.mit.edu	37	2	1914022	1914022	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:1914022G>T	uc002qxe.2	-	13	2634	c.1807C>A	c.(1807-1809)CGC>AGC	p.R603S	MYT1L_uc002qxd.2_Missense_Mutation_p.R601S|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	603					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGAGCACGCGGTCCGAGGCC	0.642			NA											32	55					2.85442e-18	6.05e-18	0.010818	1	0
NRXN1	9378	broad.mit.edu	37	2	51255149	51255149	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:51255149C>A	uc010fbq.2	-	2	1740	c.263G>T	c.(262-264)CGC>CTC	p.R88L	NRXN1_uc002rxe.3_Missense_Mutation_p.R88L|NRXN1_uc002rxd.1_Missense_Mutation_p.R88L	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAGCTGCAGGCGGCCGCCGCG	0.677			NA											13	31					0.000219431	0.000368257	0.00245	1	0
SUCLG1	8802	broad.mit.edu	37	2	84668224	84668224	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:84668224C>A	uc002son.2	-	5	729	c.536G>T	c.(535-537)GGA>GTA	p.G179V	SUCLG1_uc010ysk.1_Missense_Mutation_p.G166V	NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	179					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)	TTTACATTCTCCAGGCTGAAA	0.348	Ovarian(48;203 1101 37206 40305 50790)		NA											23	69					4.7796e-09	8.61949e-09	0.004656	1	0
RETSAT	54884	broad.mit.edu	37	2	85578057	85578057	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:85578057G>A	uc002spd.2	-	3	634	c.443C>T	c.(442-444)CCC>CTC	p.P148L	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.P87L|RETSAT_uc010fgf.2_Intron	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	148					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	AGAGGACAGGGGAGCCCAGTC	0.532			NA											48	59					0	0	0.013114	0	0
RGPD4	285190	broad.mit.edu	37	2	108487939	108487939	+	Missense_Mutation	SNP	T	T	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:108487939T>G	uc010ywk.1	+	20	3561	c.3479T>G	c.(3478-3480)TTC>TGC	p.F1160C	RGPD4_uc002tdu.2_Missense_Mutation_p.F347C|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1160	RanBD1 1.				intracellular transport		binding			skin(2)	2						GCTGAAGAATTCAAGCAGAAA	0.438			NA											14	217					0	0	0.001855	0	0
IL1F7	27178	broad.mit.edu	37	2	113674730	113674730	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:113674730C>A	uc002tij.2	+	3	212	c.170C>A	c.(169-171)CCG>CAG	p.P57Q	IL1F7_uc002tik.2_Missense_Mutation_p.P36Q|IL1F7_uc002til.2_Intron|IL1F7_uc002tim.2_Intron|IL1F7_uc002tin.2_Missense_Mutation_p.P31Q	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	57					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						AACTTAAACCCGAAGAAATTC	0.443			NA											40	85					9.9191e-30	2.36635e-29	0.00874	1	0
EN1	2019	broad.mit.edu	37	2	119600786	119600786	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:119600786C>G	uc002tlm.2	-	2	1923	c.907G>C	c.(907-909)GAC>CAC	p.D303H		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	303	Homeobox.				skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GGCCGCTTGTCCTCCTTCTCG	0.677			NA											8	19					0	0	0.00308	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540303	133540303	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:133540303G>C	uc002ttp.2	-	14	4455	c.4081C>G	c.(4081-4083)CAG>GAG	p.Q1361E	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1361							protein binding				0						CTCCCATGCTGACTGCTGAAG	0.617			NA											34	75					0	0	0.012213	0	0
NEB	4703	broad.mit.edu	37	2	152470916	152470916	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:152470916C>A	uc010fnx.2	-	73	10937	c.10746G>T	c.(10744-10746)GTG>GTT	p.V3582V		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3582	Nebulin 98.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTTGGCCAGCACCACCCCCA	0.527			NA											281	341					1.52656e-134	4.46225e-134	0.01441	1	0
SCN3A	6328	broad.mit.edu	37	2	165970341	165970341	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:165970341G>T	uc002ucx.2	-	20	4146	c.3654C>A	c.(3652-3654)CTC>CTA	p.L1218L	SCN3A_uc002ucy.2_Silent_p.L1169L|SCN3A_uc002ucz.2_Silent_p.L1169L|SCN3A_uc002uda.1_Silent_p.L1038L|SCN3A_uc002udb.1_Silent_p.L1038L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1218	Helical; Name=S1 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CACCACTACTGAGAAGGATCA	0.393			NA											24	159					2.21704e-12	4.27342e-12	0.00278	1	0
SCN3A	6328	broad.mit.edu	37	2	165987787	165987787	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:165987787C>A	uc002ucx.2	-	16	3024	c.2532G>T	c.(2530-2532)GTG>GTT	p.V844V	SCN3A_uc002ucy.2_Silent_p.V795V|SCN3A_uc002ucz.2_Silent_p.V795V|SCN3A_uc002uda.1_Silent_p.V664V|SCN3A_uc002udb.1_Silent_p.V664V	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	844						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	ACAATCCCTCCACATTTGACA	0.368			NA											58	165					1.12612e-26	2.57122e-26	0.01441	1	0
CHN1	1123	broad.mit.edu	37	2	175677163	175677163	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:175677163C>T	uc002uji.2	-	9	1290	c.760G>A	c.(760-762)GAC>AAC	p.D254N	CHN1_uc010zeq.1_Missense_Mutation_p.D228N|CHN1_uc002ujj.2_Missense_Mutation_p.D29N|CHN1_uc002ujg.2_Missense_Mutation_p.D129N	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	254	Phorbol-ester/DAG-type.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			GGCTTACAGTCATTTGGGACC	0.398			NA	T	TAF15	extraskeletal myxoid chondrosarcoma								105	88					0	0	0.01441	0	0
COL5A2	1290	broad.mit.edu	37	2	189916924	189916924	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:189916924C>A	uc002uqk.2	-	41	3018	c.2743G>T	c.(2743-2745)GGC>TGC	p.G915C	COL5A2_uc010frx.2_Missense_Mutation_p.G491C	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	915					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAACTCTGCCCGCAGAACCA	0.363			NA											75	121					2.38877e-28	5.59835e-28	0.01441	1	0
BOLL	66037	broad.mit.edu	37	2	198646503	198646503	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:198646503G>A	uc002uus.2	-	2	382	c.72C>T	c.(70-72)GCC>GCT	p.A24A	BOLL_uc002uur.2_Silent_p.A30A|BOLL_uc002uut.2_Silent_p.A36A|BOLL_uc010zha.1_5'UTR|BOLL_uc002uuu.1_Silent_p.A30A	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2	24					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						CATATCTTGGGGCACTTGTTG	0.368			NA											83	203					0	0	0.01441	0	0
CPS1	1373	broad.mit.edu	37	2	211456679	211456679	+	Missense_Mutation	SNP	G	G	A	rs149930500		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:211456679G>A	uc002vee.3	+	10	1204	c.1072G>A	c.(1072-1074)GAT>AAT	p.D358N	CPS1_uc010fur.2_Missense_Mutation_p.D364N|CPS1_uc010fus.2_5'Flank	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	358	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GAATGTCAACGATCAAACAAA	0.353			NA											41	56					0	0	0.00874	0	0
ABCA12	26154	broad.mit.edu	37	2	215807686	215807686	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:215807686A>T	uc002vew.2	-	50	7619	c.7399T>A	c.(7399-7401)TTT>ATT	p.F2467I	ABCA12_uc002vev.2_Missense_Mutation_p.F2149I|ABCA12_uc010zjn.1_Missense_Mutation_p.F1394I	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2467	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATACATTGAAACTTTCCATTC	0.393	Ovarian(66;664 1488 5121 34295)		NA											28	51					0	0	0.008361	0	0
TNS1	7145	broad.mit.edu	37	2	218713528	218713528	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:218713528C>A	uc002vgt.2	-	17	1735	c.1337G>T	c.(1336-1338)GGC>GTC	p.G446V	TNS1_uc002vgr.2_Missense_Mutation_p.G446V|TNS1_uc002vgs.2_Missense_Mutation_p.G446V|TNS1_uc010zjv.1_Missense_Mutation_p.G446V|TNS1_uc010fvj.1_Missense_Mutation_p.G514V|TNS1_uc010fvk.1_Missense_Mutation_p.G571V|TNS1_uc010fvi.1_Missense_Mutation_p.G133V	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	446						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TAAGCCAAAGCCACTCAGCAG	0.667			NA											70	96					4.46356e-37	1.11484e-36	0.01441	1	0
TTLL4	9654	broad.mit.edu	37	2	219605285	219605285	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:219605285G>A	uc002viy.2	+	5	2009	c.1639G>A	c.(1639-1641)GAA>AAA	p.E547K	TTLL4_uc010zkl.1_Missense_Mutation_p.E382K|TTLL4_uc010fvx.2_Missense_Mutation_p.E547K	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	547					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTCCCCCAGCGAATCGGTGGC	0.433	GBM(172;1818 2053 15407 20943 49753)		NA											31	246					0	0	0.00623	0	0
OBSL1	23363	broad.mit.edu	37	2	220431754	220431754	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:220431754C>A	uc010fwk.2	-	5	1989	c.1932G>T	c.(1930-1932)CAG>CAT	p.Q644H	OBSL1_uc010fwl.1_Missense_Mutation_p.Q119H|OBSL1_uc002vmi.2_Missense_Mutation_p.Q644H|OBSL1_uc002vmj.2_Missense_Mutation_p.Q231H	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	644					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		ACCAGGTACCCTGGATGATGG	0.602			NA											26	37					7.33532e-06	1.25884e-05	0.003954	1	0
KIAA1486	57624	broad.mit.edu	37	2	226446863	226446863	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:226446863G>A	uc002voe.2	+	4	905	c.730G>A	c.(730-732)GTG>ATG	p.V244M	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.V14M	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	244										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AGAGGAGCCCGTGTACATCGA	0.592			NA											14	309					0	0	0.004007	0	0
COL4A4	1286	broad.mit.edu	37	2	227892700	227892700	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:227892700C>T	uc010zlt.1	-	42	4653	c.3999G>A	c.(3997-3999)CAG>CAA	p.Q1333Q		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1333	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CATGTGGTCCCTGCGGTCCCG	0.488			NA											19	59					0	0	0.006122	0	0
RASSF2	9770	broad.mit.edu	37	20	4768901	4768901	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:4768901G>T	uc002wld.2	-	8	707	c.653C>A	c.(652-654)GCA>GAA	p.A218E	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.A218E|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	218	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						AAACTCCTCTGCTGAATTCTC	0.378	Melanoma(158;1891 3343 50738)		NA											67	71					7.33394e-39	1.86682e-38	0.01441	1	0
C20orf186	149954	broad.mit.edu	37	20	31685467	31685467	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:31685467C>A	uc010zue.1	+	11	1458	c.1443C>A	c.(1441-1443)ATC>ATA	p.I481I		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	481						cytoplasm|extracellular region	lipid binding				0						TCATCAGGATCCAGGTGCTGA	0.597			NA											93	122					8.92586e-32	2.14867e-31	0.01441	1	0
PTPRT	11122	broad.mit.edu	37	20	40730911	40730911	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:40730911C>A	uc002xkg.2	-	26	3751	c.3567G>T	c.(3565-3567)GTG>GTT	p.V1189V	PTPRT_uc010ggj.2_Silent_p.V1208V|PTPRT_uc010ggi.2_Silent_p.V392V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1189	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTCGGGCCGCACACGGGGTG	0.562			NA											18	80					1.67942e-08	3.01841e-08	0.006122	1	0
PTPRT	11122	broad.mit.edu	37	20	40743842	40743842	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:40743842C>A	uc002xkg.2	-	22	3280	c.3096G>T	c.(3094-3096)CAG>CAT	p.Q1032H	PTPRT_uc010ggj.2_Missense_Mutation_p.Q1051H|PTPRT_uc010ggi.2_Missense_Mutation_p.Q235H	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1032	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGCTTACCTTCTGGACTGTGA	0.418			NA											29	94					8.4185e-14	1.66492e-13	0.012213	1	0
TOX2	84969	broad.mit.edu	37	20	42635366	42635366	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:42635366C>A	uc002xlf.3	+	3	389	c.372C>A	c.(370-372)CTC>CTA	p.L124L	TOX2_uc010ggo.2_Silent_p.L115L|TOX2_uc002xle.3_Silent_p.L73L|TOX2_uc010ggp.2_Silent_p.L73L|TOX2_uc002xlg.2_Silent_p.L73L	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCATGGACCTCCCAGCCATCA	0.637			NA											34	24					6.90743e-12	1.32185e-11	0.003755	1	0
HNF4A	3172	broad.mit.edu	37	20	43043291	43043291	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:43043291C>A	uc002xma.2	+	5	726	c.637C>A	c.(637-639)CTG>ATG	p.L213M	HNF4A_uc002xlt.2_Missense_Mutation_p.L191M|HNF4A_uc002xlu.2_Missense_Mutation_p.L191M|HNF4A_uc002xlv.2_Missense_Mutation_p.L191M|HNF4A_uc002xly.2_Missense_Mutation_p.L213M|HNF4A_uc002xlz.2_Missense_Mutation_p.L213M|HNF4A_uc010ggq.2_Missense_Mutation_p.L206M	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	213					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGAGCTCCCCCTGGACGACCA	0.622	Colon(79;2 1269 8820 14841 52347)		NA											7	25					5.68852e-11	1.07315e-10	0.004482	1	0
CDH22	64405	broad.mit.edu	37	20	44839121	44839121	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:44839121C>A	uc002xrm.2	-	6	1512	c.1111G>T	c.(1111-1113)GAC>TAC	p.D371Y	CDH22_uc010ghk.1_Missense_Mutation_p.D371Y|CDH22_uc002xrn.1_Missense_Mutation_p.D122Y	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	371	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GTGCCCAGGTCGGCGAAGCGG	0.711			NA											14	32					7.93312e-07	1.39288e-06	0.00245	1	0
CDH22	64405	broad.mit.edu	37	20	44869744	44869744	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:44869744C>A	uc002xrm.2	-	2	809	c.408G>T	c.(406-408)CGG>CGT	p.R136R	CDH22_uc010ghk.1_Silent_p.R136R	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	136	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GAGCCTGGGCCCGCAGCGTGT	0.622			NA											24	93					7.07758e-08	1.25929e-07	0.004656	1	0
ZNF831	128611	broad.mit.edu	37	20	57768321	57768321	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:57768321C>A	uc002yan.2	+	1	2247	c.2247C>A	c.(2245-2247)GTC>GTA	p.V749V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	749						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCCCCCTGGTCTCTCCAAATG	0.642			NA											12	9					0.000978159	0.00162112	0.010729	1	0
ZNF831	128611	broad.mit.edu	37	20	57768439	57768439	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:57768439G>T	uc002yan.2	+	1	2365	c.2365G>T	c.(2365-2367)GCC>TCC	p.A789S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	789						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGAAGGAGGTGCCCGAGGTGT	0.662			NA											29	20					3.65163e-15	7.47179e-15	0.00632	1	0
C20orf151	140893	broad.mit.edu	37	20	60985978	60985978	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:60985978C>A	uc002ycw.1	-	14	2108	c.1951G>T	c.(1951-1953)GAC>TAC	p.D651Y		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	651											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			GGACTGTGGTCCTCGGCGTCC	0.677			NA											76	85					1.24833e-42	3.30405e-42	0.01441	1	0
BIRC7	79444	broad.mit.edu	37	20	61870819	61870819	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:61870819G>T	uc002yej.2	+	6	932	c.759G>T	c.(757-759)AAG>AAT	p.K253N	BIRC7_uc010gkc.1_3'UTR|BIRC7_uc002yei.2_Missense_Mutation_p.K235N	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	253	RING-type.				activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					GGACGTGCAAGGTGTGCCTGG	0.692			NA											19	126					3.32936e-07	5.86496e-07	0.006122	1	0
MYT1	4661	broad.mit.edu	37	20	62839775	62839775	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:62839775G>T	uc002yii.2	+	7	1590	c.1226G>T	c.(1225-1227)GGC>GTC	p.G409V	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_Missense_Mutation_p.G41V	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	409					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGCCAGCTGGGCCTGGGAGAG	0.657	GBM(59;481 1041 20555 21139 33705)		NA											28	26					2.12542e-12	4.11171e-12	0.00632	1	0
PCMTD2	55251	broad.mit.edu	37	20	62904813	62904813	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:62904813G>C	uc002yil.3	+	6	1146	c.946G>C	c.(946-948)GAG>CAG	p.E316Q	PCMTD2_uc002yim.3_Missense_Mutation_p.E289Q	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	316						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGACTTGGAAGAGGAACGGAG	0.537			NA											90	94					0	0	0.01441	0	0
TIAM1	7074	broad.mit.edu	37	21	32526706	32526706	+	Missense_Mutation	SNP	A	A	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr21:32526706A>C	uc002yow.1	-	18	3502	c.3030T>G	c.(3028-3030)CAT>CAG	p.H1010Q	TIAM1_uc011adk.1_Missense_Mutation_p.H1010Q|TIAM1_uc011adl.1_Missense_Mutation_p.H950Q	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1010					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GGTTCATCTCATGCAAACTGC	0.572			NA											76	62					0	0	0.01441	0	0
PDE9A	5152	broad.mit.edu	37	21	44192569	44192569	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr21:44192569C>T	uc002zbm.2	+	19	1770	c.1707C>T	c.(1705-1707)AGC>AGT	p.S569S	PDE9A_uc002zbn.2_Silent_p.S442S|PDE9A_uc002zbo.2_Silent_p.S516S|PDE9A_uc002zbp.2_Silent_p.S362S|PDE9A_uc002zbq.2_Silent_p.S467S|PDE9A_uc002zbs.2_Silent_p.S362S|PDE9A_uc002zbr.2_Silent_p.S362S|PDE9A_uc002zbt.2_Silent_p.S441S|PDE9A_uc002zbu.2_Silent_p.S435S|PDE9A_uc002zbv.2_Silent_p.S409S|PDE9A_uc002zbw.2_Silent_p.S352S|PDE9A_uc002zbx.2_Silent_p.S509S|PDE9A_uc002zby.2_Silent_p.S352S|PDE9A_uc002zbz.2_Silent_p.S461S|PDE9A_uc002zca.2_Silent_p.S528S|PDE9A_uc002zcb.2_Silent_p.S543S|PDE9A_uc002zcc.2_Silent_p.S468S|PDE9A_uc002zcd.2_Silent_p.S483S|PDE9A_uc002zce.2_Silent_p.S502S|PDE9A_uc002zcf.2_Silent_p.S362S|PDE9A_uc002zcg.2_Silent_p.S362S|PDE9A_uc002zch.2_Silent_p.S352S	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	569					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						AGACTGACAGCTTGACGTCTG	0.532			NA											10	5					0	0	0.013537	0	0
PWP2	5822	broad.mit.edu	37	21	45544482	45544482	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr21:45544482C>T	uc002zeb.2	+	15	1929	c.1839C>T	c.(1837-1839)TAC>TAT	p.Y613Y		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	613	WD 13.					cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CCCTGTGCTACTCTGCAGACG	0.562			NA											21	52					0	0	0.00333	0	0
SEZ6L	23544	broad.mit.edu	37	22	26736548	26736548	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:26736548C>A	uc003acb.2	+	10	2318	c.2162C>A	c.(2161-2163)CCT>CAT	p.P721H	SEZ6L_uc003acc.2_Missense_Mutation_p.P721H|SEZ6L_uc011akc.1_Missense_Mutation_p.P721H|SEZ6L_uc003acd.2_Missense_Mutation_p.P721H|SEZ6L_uc011akd.1_Missense_Mutation_p.P721H|SEZ6L_uc003ace.2_Missense_Mutation_p.P721H|SEZ6L_uc003acf.1_Missense_Mutation_p.P494H|SEZ6L_uc010gvc.1_Missense_Mutation_p.P494H	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	721	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CATTCGGACCCTGCTGGCCTC	0.488			NA											71	43					1.93348e-29	4.59201e-29	0.01441	1	0
SYN3	8224	broad.mit.edu	37	22	32914053	32914053	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:32914053T>A	uc003amx.2	-	12	1746	c.1587A>T	c.(1585-1587)CCA>CCT	p.P529P	SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Silent_p.P528P|SYN3_uc011amc.1_Silent_p.P163P	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	529	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						GGGGTGGTGCTGGCTTCTTGG	0.592			NA											70	55					0	0	0.01441	0	0
PNPLA3	80339	broad.mit.edu	37	22	44333104	44333104	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:44333104C>T	uc003bei.1	+	6	1104	c.931C>T	c.(931-933)CCC>TCC	p.P311S	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	311	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				CAGCATCCTGCCCTGGGATGA	0.607			NA											10	38					0	0	0.006214	0	0
PHF21B	112885	broad.mit.edu	37	22	45312349	45312349	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:45312349C>T	uc003bfn.2	-	4	526	c.375G>A	c.(373-375)GCG>GCA	p.A125A	PHF21B_uc003bfm.2_5'UTR|PHF21B_uc011aqk.1_Silent_p.A113A|PHF21B_uc011aql.1_Silent_p.A125A|PHF21B_uc011aqm.1_Silent_p.A113A	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	125							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GGCTGCCGGGCGCTGGCACAT	0.701			NA											23	64					0	0	0.00333	0	0
SUMF1	285362	broad.mit.edu	37	3	4459759	4459759	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:4459759C>A	uc003bpz.1	-	5	685	c.660G>T	c.(658-660)TGG>TGT	p.W220C	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Missense_Mutation_p.W195C|SUMF1_uc010hby.1_Missense_Mutation_p.W220C|SUMF1_uc011ast.1_Intron	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	220						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		GCTTCCCTGCCCAAGTGCAGT	0.502			NA											108	69					1.09905e-38	2.78425e-38	0.01441	1	0
NUP210	23225	broad.mit.edu	37	3	13415250	13415250	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:13415250C>A	uc003bxv.1	-	12	1638	c.1555G>T	c.(1555-1557)GTG>TTG	p.V519L	NUP210_uc003bxx.2_Missense_Mutation_p.V191L	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	519	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GGGTTCTGCACATCATGTGCC	0.587			NA											43	25					2.43139e-17	5.09252e-17	0.01441	1	0
ULK4	54986	broad.mit.edu	37	3	41996204	41996204	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:41996204A>T	uc003ckv.3	-	2	249	c.48T>A	c.(46-48)ACT>ACA	p.T16T	ULK4_uc003ckw.2_Silent_p.T16T|ULK4_uc003ckx.1_Silent_p.T16T	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	16	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TATAGACAACAGTCTTGCTTC	0.418			NA											75	50					0	0	0.01441	0	0
RHOA	387	broad.mit.edu	37	3	49412905	49412905	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:49412905C>A	uc003cwu.2	-	2	394	c.118G>T	c.(118-120)GAG>TAG	p.E40*	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438			NA											118	91					3.41453e-61	9.51063e-61	0.01441	1	0
IL17RD	54756	broad.mit.edu	37	3	57130439	57130439	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:57130439G>A	uc003dil.2	-	13	2291	c.2202C>T	c.(2200-2202)CAC>CAT	p.H734H	IL17RD_uc003dik.2_Silent_p.H710H|IL17RD_uc010hna.2_Silent_p.H590H	NM_017563	NP_060033	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D precursor	734	Cytoplasmic (Potential).					Golgi membrane|integral to membrane|plasma membrane	receptor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		GGGCGACCGCGTGGAGTTCAT	0.547			NA											116	65					0	0	0.01441	0	0
ARL6	84100	broad.mit.edu	37	3	97506897	97506897	+	Missense_Mutation	SNP	T	T	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:97506897T>G	uc003drv.2	+	7	726	c.413T>G	c.(412-414)GTG>GGG	p.V138G	ARL6_uc003drw.2_RNA|ARL6_uc003dru.2_Missense_Mutation_p.V138G|ARL6_uc010hoy.2_Missense_Mutation_p.V138G	NM_177976	NP_816931	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	138					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		AGAGATGCAGTGACATCTGTA	0.323			NA							Bardet-Biedl_syndrome				29	42					0	0	0.00632	0	0
GATA2	2624	broad.mit.edu	37	3	128200788	128200788	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:128200788C>A	uc003ekm.3	-	6	1453	c.1018_splice	c.e6-1	p.S340_splice	GATA2_uc003ekn.3_Intron|GATA2_uc003eko.2_Splice_Site_p.S340_splice	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1						blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		TGGCGGCCGACTGGGAGGGCA	0.443			NA	Mis		AML(CML blast transformation)								39	18					3.61848e-18	7.63901e-18	0.007835	1	0
IGSF10	285313	broad.mit.edu	37	3	151164418	151164418	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:151164418G>A	uc011bod.1	-	4	3351	c.3351C>T	c.(3349-3351)CCC>CCT	p.P1117P		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1117					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTCTACACTGGGTTTGTTCT	0.433			NA											127	84					0	0	0.01441	0	0
FAM193A	8603	broad.mit.edu	37	4	2661397	2661397	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:2661397G>T	uc010icl.2	+	7	980	c.629G>T	c.(628-630)AGA>ATA	p.R210I	FAM193A_uc010ick.2_Missense_Mutation_p.R410I|FAM193A_uc003gfd.2_Missense_Mutation_p.R210I|FAM193A_uc011bvm.1_Missense_Mutation_p.R234I|FAM193A_uc011bvn.1_Missense_Mutation_p.R210I|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.R64I	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	210										ovary(3)	3						TACAGGAGAAGGTAAGGCTGG	0.552			NA											22	142					1.55795e-14	3.11589e-14	0.012319	1	0
CLNK	116449	broad.mit.edu	37	4	10527500	10527500	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:10527500G>T	uc003gmo.3	-	14	833	c.696C>A	c.(694-696)AAC>AAA	p.N232K		NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	232					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						GAGTATTTTGGTTTTCTAACA	0.418	GBM(87;402 1286 6949 13902 35851)		NA											12	0					6.81908e-15	1.38464e-14	0.00245	1	0
NKX3-2	579	broad.mit.edu	37	4	13543927	13543927	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:13543927A>T	uc003gmx.2	-	2	768	c.692T>A	c.(691-693)CTG>CAG	p.L231Q		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	231	Homeobox.				negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGCCCGGACAGGTAGCGCTG	0.617			NA											7	14					0	0	0.001984	0	0
ARAP2	116984	broad.mit.edu	37	4	36148964	36148964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:36148964G>A	uc003gsq.1	-	19	3555	c.3217C>T	c.(3217-3219)CAA>TAA	p.Q1073*		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1073	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCCCCATTTTGAACCATTGTG	0.353			NA											211	120					0	0	0.01441	0	0
N4BP2	55728	broad.mit.edu	37	4	40122701	40122701	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:40122701A>G	uc003guy.3	+	9	3308	c.2970A>G	c.(2968-2970)GTA>GTG	p.V990V	N4BP2_uc010ifq.2_Silent_p.V910V|N4BP2_uc010ifr.2_Silent_p.V910V	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	990						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CTGGAGTAGTAGAACCACAAA	0.448			NA											26	111					0	0	0.00632	0	0
LRRC66	339977	broad.mit.edu	37	4	52861367	52861367	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:52861367C>A	uc003gzi.2	-	4	1834	c.1821G>T	c.(1819-1821)GGG>GGT	p.G607G		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	607						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GTTCAGTGCCCCCTCTTTCCT	0.463			NA											33	174					9.65021e-13	1.87369e-12	0.010818	1	0
CLOCK	9575	broad.mit.edu	37	4	56336970	56336970	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:56336970G>C	uc003haz.1	-	9	1278	c.352C>G	c.(352-354)CTT>GTT	p.L118V	CLOCK_uc003hba.1_Missense_Mutation_p.L118V	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	118	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			AAACCATCAAGAGCCTGAAAT	0.274			NA											29	76					0	0	0.009535	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182639	57182639	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:57182639C>T	uc003hbk.2	+	8	3362	c.2971C>T	c.(2971-2973)CGC>TGC	p.R991C	KIAA1211_uc010iha.2_Missense_Mutation_p.R984C|KIAA1211_uc011bzz.1_Missense_Mutation_p.R901C|KIAA1211_uc003hbm.1_Missense_Mutation_p.R877C	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	991	Pro-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCTGCTGTCTCGCCGAGCGGG	0.662			NA											7	20					0	0	0.001984	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962246	69962246	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:69962246T>C	uc003heg.3	+	1	54	c.8T>C	c.(7-9)GTG>GCG	p.V3A	UGT2B7_uc010ihq.2_Missense_Mutation_p.V3A	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	3					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AGGATGTCTGTGAAATGGACT	0.408			NA											39	82					0	0	0.006999	0	0
SULT1B1	27284	broad.mit.edu	37	4	70596345	70596345	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:70596345C>A	uc003hen.2	-	7	950	c.652G>T	c.(652-654)GAT>TAT	p.D218Y		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	218	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						AAGATCTCATCATTCAGGTTC	0.363			NA											12	46					6.40141e-05	0.000108113	0.010729	1	0
AFM	173	broad.mit.edu	37	4	74357672	74357672	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:74357672G>A	uc003hhb.2	+	8	958	c.927G>A	c.(925-927)GAG>GAA	p.E309E		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	309	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAATACCAGAGCGCGGCCAGT	0.353			NA											33	68					0	0	0.010818	0	0
PRDM8	56978	broad.mit.edu	37	4	81123121	81123121	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:81123121C>T	uc010ijo.2	+	8	1344	c.505C>T	c.(505-507)CCC>TCC	p.P169S	PRDM8_uc003hmb.3_Missense_Mutation_p.P169S|PRDM8_uc003hmc.3_Missense_Mutation_p.P169S	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	169	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GTTTGAGTTCCCCTATGTGGC	0.388			NA									OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	136					0	0	0.01441	0	0
DSPP	1834	broad.mit.edu	37	4	88535365	88535365	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:88535365C>G	uc003hqu.2	+	5	1671	c.1551C>G	c.(1549-1551)AGC>AGG	p.S517R		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	517	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		ACAGTGATAGCACATCAGACA	0.378			NA											16	41					0	0	0.004007	0	0
MEPE	56955	broad.mit.edu	37	4	88767088	88767088	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:88767088C>A	uc003hqy.2	+	4	1107	c.1068C>A	c.(1066-1068)AAC>AAA	p.N356K	MEPE_uc010ikn.2_Missense_Mutation_p.N243K	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	356					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding	p.N356K(1)		ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		GAGAAGGAAACAGAGTGGATG	0.478			NA											21	45					8.34094e-07	1.45966e-06	0.008871	1	0
FAM190A	401145	broad.mit.edu	37	4	91549341	91549341	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:91549341A>T	uc003hsv.3	+	6	2230	c.1890A>T	c.(1888-1890)GCA>GCT	p.A630A	FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Silent_p.A630A	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	630										large_intestine(1)|ovary(1)	2						ACTGCACGGCAGTCAAGACGT	0.418			NA											33	51					0	0	0.013726	0	0
NDST4	64579	broad.mit.edu	37	4	115769409	115769409	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:115769409C>A	uc003ibu.2	-	9	2581	c.1902G>T	c.(1900-1902)CAG>CAT	p.Q634H	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	634	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CATTAAAGAACTGAACTTCCT	0.328			NA											49	89					5.57489e-27	1.28391e-26	0.01441	1	0
KIAA1109	84162	broad.mit.edu	37	4	123094284	123094284	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:123094284A>G	uc003ieh.2	+	2	236	c.191A>G	c.(190-192)TAC>TGC	p.Y64C		NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	64					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AACAGATTATACAAGCATGGC	0.289			NA											68	117					0	0	0.01441	0	0
FNIP2	57600	broad.mit.edu	37	4	159790038	159790038	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:159790038G>C	uc003iqe.3	+	13	2433	c.2250G>C	c.(2248-2250)GAG>GAC	p.E750D		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	750	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CCTCCTTGGAGGCCAGTGAGG	0.517			NA											38	81					0	0	0.003755	0	0
KLKB1	3818	broad.mit.edu	37	4	187173004	187173004	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:187173004G>A	uc003iyy.2	+	10	1204	c.1133G>A	c.(1132-1134)GGG>GAG	p.G378E	KLKB1_uc011clc.1_Missense_Mutation_p.G176E|KLKB1_uc011cld.1_Missense_Mutation_p.G340E	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	378					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TGTAACACTGGGGACAACTCT	0.418			NA											42	88					0	0	0.010771	0	0
TRIML1	339976	broad.mit.edu	37	4	189060808	189060808	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:189060808G>T	uc003izm.1	+	1	211	c.96G>T	c.(94-96)GGG>GGT	p.G32G		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	32	RING-type.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCGAGTGTGGGCACAGCTTTT	0.517	Melanoma(31;213 1036 16579 23968 32372)		NA											68	192					7.1157e-29	1.68247e-28	0.01441	1	0
CTNND2	1501	broad.mit.edu	37	5	11384809	11384809	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:11384809G>A	uc003jfa.1	-	7	1290	c.1145C>T	c.(1144-1146)ACG>ATG	p.T382M	CTNND2_uc010itt.2_Missense_Mutation_p.T291M|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Intron|CTNND2_uc010itu.1_Intron|CTNND2_uc011cmx.1_Translation_Start_Site	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	382					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GAGGGTGGCCGTGGCATACAG	0.701			NA											10	19					0	0	0.010729	0	0
CDH9	1007	broad.mit.edu	37	5	26881508	26881508	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:26881508T>A	uc003jgs.1	-	12	2276	c.2107A>T	c.(2107-2109)ACT>TCT	p.T703S	CDH9_uc011cnv.1_Missense_Mutation_p.T296S	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	703	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AGAGGCACAGTCCTCCTTATC	0.418	Melanoma(8;187 585 15745 40864 52829)		NA											101	98					0	0	0.01441	0	0
EGFLAM	133584	broad.mit.edu	37	5	38337723	38337723	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:38337723G>T	uc003jlc.1	+	2	523	c.199G>T	c.(199-201)GGG>TGG	p.G67W	EGFLAM_uc003jlb.1_Missense_Mutation_p.G67W	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	67	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TCCCATCCTTGGGTACACTGT	0.512	Colon(62;485 1295 3347 17454)		NA											9	8					0.000442599	0.000735821	0.006214	1	0
EDIL3	10085	broad.mit.edu	37	5	83402473	83402473	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:83402473C>A	uc003kio.1	-	6	1064	c.645G>T	c.(643-645)TGG>TGT	p.W215C	EDIL3_uc003kip.1_Missense_Mutation_p.W205C	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	215	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TTACCTGAATCCACGGCCATC	0.398			NA											75	47					1.43161e-34	3.526e-34	0.01441	1	0
DMXL1	1657	broad.mit.edu	37	5	118469357	118469357	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:118469357G>T	uc003ksd.2	+	12	1919	c.1738G>T	c.(1738-1740)GGT>TGT	p.G580C	DMXL1_uc010jcl.1_Missense_Mutation_p.G580C|DMXL1_uc003ksc.1_Missense_Mutation_p.G580C	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	580	WD 5.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATTTCTTCTGGTCACAATAA	0.373			NA											22	61					4.35082e-09	7.87291e-09	0.010504	1	0
SLC22A5	6584	broad.mit.edu	37	5	131705782	131705782	+	Missense_Mutation	SNP	G	G	C	rs148657753		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:131705782G>C	uc003kww.3	+	1	382	c.118G>C	c.(118-120)GTG>CTG	p.V40L	SLC22A5_uc003kwx.3_Missense_Mutation_p.V40L|uc003kwu.1_5'Flank	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	40	Helical; Name=1; (Potential).				positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CCTGTCCTCCGTGTTCCTGAT	0.687			NA									OREG0003451	type=REGULATORY REGION|Gene=BC043424|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	3					0	0	0.003954	0	0
EGR1	1958	broad.mit.edu	37	5	137802542	137802542	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:137802542G>T	uc003ldb.1	+	2	674	c.404G>T	c.(403-405)GGC>GTC	p.G135V	EGR1_uc011cyu.1_Missense_Mutation_p.G135V	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	135					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCTATACTGGCCGCTTTTCC	0.582			NA											86	50					1.46381e-53	4.01415e-53	0.01441	1	0
PCDHA8	56140	broad.mit.edu	37	5	140222535	140222535	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140222535G>T	uc003lhs.2	+	1	1629	c.1629G>T	c.(1627-1629)CCG>CCT	p.P543P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.P543P	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	543	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGCGTGCCGCCTCTGGGCA	0.687			NA											125	47					1.22322e-63	3.44312e-63	0.01441	1	0
PCDHB14	56122	broad.mit.edu	37	5	140603356	140603356	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140603356C>A	uc003ljb.2	+	1	279	c.279C>A	c.(277-279)GAC>GAA	p.D93E	PCDHB14_uc011dal.1_Intron	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	93	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGACCGAGACGAGCTGTGTG	0.448	Ovarian(141;50 1831 27899 33809 37648)		NA											147	119					9.53643e-70	2.69861e-69	0.01441	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140731926	140731926	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140731926T>A	uc003ljo.1	+	1	2099	c.2099T>A	c.(2098-2100)CTC>CAC	p.L700H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.L700H|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	700	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTCTTTCTCCTCGCGGTG	0.607			NA											159	93					0	0	0.01441	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140869611	140869611	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140869611T>A	uc003lla.1	+	1	804	c.804T>A	c.(802-804)GAT>GAA	p.D268E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Missense_Mutation_p.D268E	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	268	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCACTGATCCAGACGAGG	0.527			NA											166	83					0	0	0.01441	0	0
DCTN4	51164	broad.mit.edu	37	5	150138543	150138543	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:150138543G>A	uc003lsv.2	-	1	115	c.13C>T	c.(13-15)CTG>TTG	p.L5L	DCTN4_uc003lsu.2_5'Flank|DCTN4_uc010jhi.2_Silent_p.L5L|DCTN4_uc010jhj.2_RNA|DCTN4_uc011dck.1_5'Flank	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	5						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCGACTGCAGCAAGGACGCC	0.612			NA											69	50					0	0	0.01441	0	0
TIMD4	91937	broad.mit.edu	37	5	156390260	156390260	+	Translation_Start_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:156390260C>A	uc003lwh.2	-	1	7	c.-50G>T	c.(-52--48)GAGGT>GATGT		TIMD4_uc010jii.2_Translation_Start_Site	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain							integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAAGCCCAACCTCTTATATCC	0.463			NA											55	29					1.67886e-27	3.90023e-27	0.01441	1	0
FAM71B	153745	broad.mit.edu	37	5	156589539	156589539	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:156589539A>G	uc003lwn.2	-	2	1837	c.1737T>C	c.(1735-1737)GGT>GGC	p.G579G		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	579						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTCCTGGCCACCCTGGGCTT	0.478			NA											225	154					0	0	0.01441	0	0
EHMT2	10919	broad.mit.edu	37	6	31852716	31852716	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:31852716C>T	uc003nxz.1	-	19	2431	c.2421G>A	c.(2419-2421)CGG>CGA	p.R807R	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_Silent_p.R5R|EHMT2_uc003nxy.1_Silent_p.R598R|EHMT2_uc011don.1_Silent_p.R830R|EHMT2_uc003nya.1_Silent_p.R773R	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	807	ANK 5.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CGTCGGCGCCCCGCGTCAGTA	0.637			NA											19	49					0	0	0.007413	0	0
EGFL8	80864	broad.mit.edu	37	6	32135340	32135340	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:32135340C>A	uc003oab.1	+	8	800	c.742C>A	c.(742-744)CAG>AAG	p.Q248K	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.Q248K	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	248						extracellular region|integral to membrane	calcium ion binding				0						TGAAGAGCTGCAGCCAGAACA	0.637			NA											57	74					7.36392e-32	1.78073e-31	0.01441	1	0
SPDEF	25803	broad.mit.edu	37	6	34506078	34506078	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:34506078G>A	uc003ojq.1	-	6	1396	c.981C>T	c.(979-981)CTC>CTT	p.L327L	SPDEF_uc011dsq.1_Silent_p.L311L	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	327	ETS.				negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						ACTGGTAGACGAGGCGCTGGG	0.632			NA											37	141					0	0	0.009718	0	0
MDFI	4188	broad.mit.edu	37	6	41621193	41621193	+	Silent	SNP	C	C	A	rs141575722		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:41621193C>A	uc003oqp.3	+	6	950	c.621C>A	c.(619-621)GGC>GGA	p.G207G	MDFI_uc003oqq.3_Silent_p.G207G|MDFI_uc010jxn.2_Silent_p.G207G	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	207	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			GTGGCTCTGGCGAGTGTGCCG	0.657			NA											43	132					3.54561e-26	8.06095e-26	0.009718	1	0
GPR115	221393	broad.mit.edu	37	6	47681561	47681561	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:47681561C>A	uc003oza.1	+	6	838	c.580C>A	c.(580-582)CTC>ATC	p.L194I	GPR115_uc003oyz.1_Missense_Mutation_p.L251I|GPR115_uc003ozb.1_Missense_Mutation_p.L192I	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	194	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CAACCACATCCTCGACACAGC	0.413	GBM(22;431 510 9010 26644 32828)		NA											59	63					7.82978e-24	1.7356e-23	0.01441	1	0
CRISP2	7180	broad.mit.edu	37	6	49666177	49666177	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:49666177A>T	uc003ozq.2	-	7	571	c.315T>A	c.(313-315)ACT>ACA	p.T105T	CRISP2_uc003ozl.2_Silent_p.T105T|CRISP2_uc003ozn.2_Silent_p.T105T|CRISP2_uc003ozr.2_Silent_p.T105T|CRISP2_uc003ozo.2_Silent_p.T105T|CRISP2_uc003ozm.2_Silent_p.T105T|CRISP2_uc003ozp.2_Silent_p.T105T	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	105						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGACCAGGAAGTAGGGTCAC	0.413			NA											23	104					0	0	0.00333	0	0
PKHD1	5314	broad.mit.edu	37	6	51483892	51483892	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:51483892T>C	uc003pah.1	-	67	12488	c.12212A>G	c.(12211-12213)CAG>CGG	p.Q4071R		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	4071	Cytoplasmic (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAGTTGCTCCTGAATAGTTTC	0.517			NA											3	132					0	0	0.009096	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757835	62757835	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:62757835G>T	uc003peg.2	-	3	531	c.284C>A	c.(283-285)ACA>AAA	p.T95K		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	95	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTTAGCACCTGTTTCTTCCTG	0.378			NA											52	99					2.0833e-19	4.48711e-19	0.01441	1	0
COL12A1	1303	broad.mit.edu	37	6	75813479	75813479	+	Silent	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:75813479C>G	uc003phs.2	-	55	8479	c.8313G>C	c.(8311-8313)GGG>GGC	p.G2771G	COL12A1_uc003pht.2_Silent_p.G1607G	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2771	Triple-helical region (COL2) with 1 imperfection.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TTACAATTGCCCCACTGATAC	0.343			NA											9	37					0	0	0.008291	0	0
COL12A1	1303	broad.mit.edu	37	6	75825638	75825638	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:75825638C>A	uc003phs.2	-	49	7725	c.7559G>T	c.(7558-7560)GGT>GTT	p.G2520V	COL12A1_uc003pht.2_Missense_Mutation_p.G1356V	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2520	TSP N-terminal.|Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CATTTTAAAACCTTTACATCA	0.338			NA											29	56					5.77227e-19	1.23327e-18	0.008361	1	0
SNAP91	9892	broad.mit.edu	37	6	84269919	84269919	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:84269919A>T	uc011dze.1	-	27	2852	c.2535T>A	c.(2533-2535)GCT>GCA	p.A845A	SNAP91_uc011dzd.1_Silent_p.A343A|SNAP91_uc003pkb.2_Silent_p.A754A|SNAP91_uc003pkc.2_Silent_p.A815A|SNAP91_uc003pkd.2_Silent_p.A538A|SNAP91_uc003pka.2_Silent_p.A843A	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	845	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TGCCTGTCCCAGCAGGAGGCT	0.542			NA											26	57					0	0	0.005443	0	0
HTR1E	3354	broad.mit.edu	37	6	87725963	87725963	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:87725963G>T	uc003pli.2	+	2	1614	c.911G>T	c.(910-912)TGG>TTG	p.W304L		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	304	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATTTTATCCTGGCTGCCATTT	0.512			NA											81	166					6.47592e-44	1.73125e-43	0.01441	1	0
LAMA4	3910	broad.mit.edu	37	6	112455712	112455712	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:112455712C>T	uc003pvu.2	-	26	3823	c.3514G>A	c.(3514-3516)GAT>AAT	p.D1172N	LAMA4_uc003pvv.2_Missense_Mutation_p.D1165N|LAMA4_uc003pvt.2_Missense_Mutation_p.D1165N	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1172	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ATGTATATATCTGTAAAAGGT	0.373			NA											17	59					0	0	0.006122	0	0
DSE	29940	broad.mit.edu	37	6	116757507	116757507	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:116757507G>C	uc003pws.2	+	6	2070	c.1876G>C	c.(1876-1878)GAG>CAG	p.E626Q	DSE_uc011ebg.1_Missense_Mutation_p.E645Q|DSE_uc003pwt.2_Missense_Mutation_p.E626Q|DSE_uc003pwu.2_Missense_Mutation_p.E293Q	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	626					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TGGCTACAGCGAGAAAGCAAC	0.493			NA											24	68					0	0	0.004656	0	0
GPRC6A	222545	broad.mit.edu	37	6	117130692	117130692	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:117130692G>T	uc003pxj.1	-	2	305	c.283C>A	c.(283-285)CTG>ATG	p.L95M	GPRC6A_uc003pxk.1_Missense_Mutation_p.L95M|GPRC6A_uc003pxl.1_Missense_Mutation_p.L95M	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	95	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TCATACCCCAGTTTGACTCCA	0.408			NA											17	47					8.60227e-14	1.69497e-13	0.004007	1	0
LPA	4018	broad.mit.edu	37	6	161007518	161007518	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:161007518C>A	uc003qtl.2	-	26	4212	c.4092G>T	c.(4090-4092)GTG>GTT	p.V1364V		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3872	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GAACTGGGACCACCGTGGGAG	0.493			NA											32	108					4.34311e-12	8.34127e-12	0.003271	1	0
PDE10A	10846	broad.mit.edu	37	6	165842178	165842178	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:165842178C>A	uc003qun.2	-	11	1034	c.793G>T	c.(793-795)GTT>TTT	p.V265F	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.V195F|PDE10A_uc003quo.2_Missense_Mutation_p.V275F	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	265					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCTATTGCAACTATGTTATCA	0.308	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											11	23					1.58986e-06	2.74613e-06	0.008291	1	0
ABCA13	154664	broad.mit.edu	37	7	48390325	48390325	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:48390325C>A	uc003toq.2	+	30	10315	c.10290C>A	c.(10288-10290)TGC>TGA	p.C3430*	ABCA13_uc010kys.1_Nonsense_Mutation_p.C504*|ABCA13_uc003tos.1_Nonsense_Mutation_p.C256*	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3430					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCTCTTCCTGCGTGGCACTGA	0.522			NA											79	98					8.41775e-28	1.96414e-27	0.01441	1	0
ELN	2006	broad.mit.edu	37	7	73456964	73456964	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:73456964G>T	uc003tzw.2	+	6	344	c.253G>T	c.(253-255)GTT>TTT	p.V85F	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_RNA|ELN_uc011kfe.1_Intron|ELN_uc003tzn.2_Missense_Mutation_p.V85F|ELN_uc003tzz.2_Missense_Mutation_p.V73F|ELN_uc003tzo.2_Missense_Mutation_p.V85F|ELN_uc003tzp.2_Missense_Mutation_p.V75F|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Missense_Mutation_p.V85F|ELN_uc003tzt.2_Missense_Mutation_p.V85F|ELN_uc003tzu.2_Missense_Mutation_p.V85F|ELN_uc003tzv.2_Missense_Mutation_p.V75F|ELN_uc003tzx.2_Missense_Mutation_p.V75F|ELN_uc011kff.1_Missense_Mutation_p.V85F|ELN_uc003tzy.2_Missense_Mutation_p.V75F	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	85					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTTCCCCGCAGTTACCTTTCC	0.632			NA	T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						59	88					1.69475e-38	4.27303e-38	0.01441	1	0
GTF2IRD1	9569	broad.mit.edu	37	7	73969507	73969507	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:73969507C>T	uc003uaq.2	+	18	2313	c.1920C>T	c.(1918-1920)CCC>CCT	p.P640P	GTF2IRD1_uc010lbq.2_Silent_p.P672P|GTF2IRD1_uc003uap.2_Silent_p.P640P|GTF2IRD1_uc003uar.1_Silent_p.P640P	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	640	GTF2I-like 3.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						TTTCCAGGCCCGAGCTGCTCA	0.622			NA											14	137					0	0	0.004007	0	0
NPTX2	4885	broad.mit.edu	37	7	98254413	98254413	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:98254413C>A	uc003upl.2	+	3	1000	c.823C>A	c.(823-825)CAG>AAG	p.Q275K		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	275	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GGTGCCAGGGCAGGCCAACGA	0.642			NA											24	105					3.10358e-05	5.27509e-05	0.014323	1	0
AASS	10157	broad.mit.edu	37	7	121758465	121758465	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:121758465C>A	uc003vka.2	-	5	679	c.583G>T	c.(583-585)GTG>TTG	p.V195L	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.V195L|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	195	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACAGCTTGCACAGCCTGACTG	0.408			NA											61	70					7.82978e-24	1.7356e-23	0.01441	1	0
GRM8	2918	broad.mit.edu	37	7	126544704	126544704	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:126544704G>T	uc003vlr.2	-	3	1072	c.761C>A	c.(760-762)CCA>CAA	p.P254Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.P254Q|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	254	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGGTTCACGTGGGATTTTCTG	0.393			NA								HNSCC(24;0.065)			30	101					6.04164e-23	1.33367e-22	0.010818	1	0
LRRC4	64101	broad.mit.edu	37	7	127670542	127670542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:127670542G>T	uc003vmk.2	-	2	289	c.152C>A	c.(151-153)TCG>TAG	p.S51*	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	51	LRRNT.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GTTACTGCACGAGCAGACGGA	0.647			NA											79	92					7.63117e-38	1.91499e-37	0.01441	1	0
AHCYL2	23382	broad.mit.edu	37	7	129043237	129043237	+	Silent	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:129043237G>C	uc011kov.1	+	7	990	c.936G>C	c.(934-936)GGG>GGC	p.G312G	AHCYL2_uc003vot.2_Silent_p.G311G|AHCYL2_uc003vov.2_Silent_p.G209G|AHCYL2_uc011kow.1_Silent_p.G210G|AHCYL2_uc011kox.1_Silent_p.G209G	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	312					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						ATGATGGAGGGGATCTTACCC	0.408	Pancreas(160;1736 1964 29875 40941 45605)		NA											93	118					0	0	0.01441	0	0
JHDM1D	80853	broad.mit.edu	37	7	139827360	139827360	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:139827360T>C	uc003vvm.2	-	5	587	c.583A>G	c.(583-585)ATT>GTT	p.I195V		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	195					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GCCACATCAATGACATCTATC	0.353			NA											67	210					0	0	0.01441	0	0
PIP	5304	broad.mit.edu	37	7	142832325	142832326	+	Nonsense_Mutation	DNP	CA	CA	AG			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:142832325_142832326CA>AG	uc003wcf.1	+	2	170_171	c.134_135CA>AG	c.(133-135)TCA>TAG	p.S45*		NM_002652	NP_002643	P12273	PIP_HUMAN	prolactin-induced protein precursor	45						extracellular region	actin binding			ovary(1)	1	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		ATTCCCAAGTCAGTACGTCCAA	0.446			NA											13	17					0	0	0.004672	0	0
SSPO	23145	broad.mit.edu	37	7	149502627	149502627	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:149502627G>T	uc010lpk.2	+	58	8440	c.8440G>T	c.(8440-8442)GGA>TGA	p.G2814*		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2814	TSP type-1 7.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCCTGCCCAGGAGATGCCAC	0.682			NA											23	53					2.52088e-20	5.45165e-20	0.00278	1	0
GIMAP4	55303	broad.mit.edu	37	7	150269516	150269516	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:150269516G>T	uc003whl.2	+	3	440	c.358G>T	c.(358-360)GTG>TTG	p.V120L	GIMAP4_uc011kuu.1_Intron|GIMAP4_uc011kuv.1_Missense_Mutation_p.V134L	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	120							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTGCTTCTGGTGGTTCCACT	0.493			NA											22	71					7.87624e-14	1.56349e-13	0.00278	1	0
ATG9B	285973	broad.mit.edu	37	7	150720252	150720252	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:150720252C>A	uc011kvc.1	-	4	777	c.701G>T	c.(700-702)CGA>CTA	p.R234L	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	234	Lumenal (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATCCACGCATCGAAGGAGGAA	0.542			NA											85	200					5.92634e-42	1.55311e-41	0.01441	1	0
WDR60	55112	broad.mit.edu	37	7	158715218	158715218	+	Missense_Mutation	SNP	A	A	C	rs2730238		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:158715218A>C	uc003woe.3	+	16	2230	c.2072A>C	c.(2071-2073)AAA>ACA	p.K691T	WDR60_uc010lqv.2_Intron|WDR60_uc010lqw.2_Missense_Mutation_p.K323T	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	691										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		GGGCCACAGAAAGTTCTGATA	0.552			NA											11	38					0	0	0.008291	0	0
LZTS1	11178	broad.mit.edu	37	8	20110358	20110358	+	Nonsense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:20110358T>A	uc003wzr.2	-	2	1195	c.1084A>T	c.(1084-1086)AAG>TAG	p.K362*	LZTS1_uc010ltg.1_Nonsense_Mutation_p.K362*	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	362	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GACCTGAGCTTGGTCTCCAGC	0.642			NA											23	63					0	0	0.014323	0	0
CLU	1191	broad.mit.edu	37	8	27466544	27466544	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:27466544C>A	uc003xfw.1	-	2	215	c.157G>T	c.(157-159)GTG>TTG	p.V53L	CLU_uc010lux.1_Intron|CLU_uc003xfx.1_Missense_Mutation_p.V53L|CLU_uc003xfy.1_Missense_Mutation_p.V64L|CLU_uc003xfz.1_Missense_Mutation_p.V105L	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	53					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATCTGTTTCACCCCGTTGACA	0.443			NA											77	166					6.20995e-33	1.51546e-32	0.01441	1	0
UNC5D	137970	broad.mit.edu	37	8	35616958	35616958	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:35616958T>C	uc003xjr.1	+	14	2612	c.2284T>C	c.(2284-2286)TGG>CGG	p.W762R	UNC5D_uc003xjs.1_Missense_Mutation_p.W757R|UNC5D_uc003xju.1_Missense_Mutation_p.W338R	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	762	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCATTCCTCTGGAGAATTAA	0.458			NA											4	411					0	0	0.000602	0	0
HTRA4	203100	broad.mit.edu	37	8	38845496	38845496	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:38845496G>A	uc003xmj.2	+	9	1425	c.1310G>A	c.(1309-1311)GGG>GAG	p.G437E		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	437	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			AACATAAATGGGAAACCTATT	0.383			NA											31	61					0	0	0.010818	0	0
SNTG1	54212	broad.mit.edu	37	8	51465741	51465741	+	Splice_Site	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:51465741T>A	uc010lxy.1	+	13	1181	c.810_splice	c.e13+2	p.N270_splice	SNTG1_uc003xqs.1_Splice_Site_p.N270_splice|SNTG1_uc010lxz.1_Splice_Site_p.N270_splice|SNTG1_uc011ldl.1_Splice_Site	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AAGCACAATGTAAGTAATGAT	0.408			NA											29	42					0	0	0.010818	0	0
PXDNL	137902	broad.mit.edu	37	8	52359687	52359687	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:52359687G>A	uc003xqu.3	-	12	1503	c.1402C>T	c.(1402-1404)CTC>TTC	p.L468F		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	468	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCAGAGGAGAGAACTGTATGC	0.507			NA											33	228					0	0	0.009535	0	0
RP1	6101	broad.mit.edu	37	8	55537428	55537428	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:55537428G>T	uc003xsd.1	+	4	1134	c.986G>T	c.(985-987)GGC>GTC	p.G329V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	329					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AATCAAGACGGCACTATGACA	0.323	Colon(91;1014 1389 7634 14542 40420)		NA											20	65					5.03518e-11	9.5328e-11	0.007413	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75924705	75924706	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:75924705_75924706GG>TT	uc003yan.2	+	3	671_672	c.296_297GG>TT	c.(295-297)TGG>TTT	p.W99F	CRISPLD1_uc011lfk.1_5'UTR|CRISPLD1_uc011lfl.1_5'UTR	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	99						extracellular region		p.W99R(1)		ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GCAGAATCCTGGGCTGAAAGTT	0.441			NA											58	96					0	0	0.004672	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775684	77775684	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:77775684C>A	uc003yav.2	+	11	9986	c.9599C>A	c.(9598-9600)GCA>GAA	p.A3200E		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3196						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTTGCAGGCATTACAGAAT	0.438			NA								HNSCC(33;0.089)			119	215					2.06061e-42	5.42696e-42	0.01441	1	0
ZBTB10	65986	broad.mit.edu	37	8	81399761	81399761	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:81399761C>A	uc003ybx.3	+	1	1314	c.716C>A	c.(715-717)CCC>CAC	p.P239H	ZBTB10_uc003ybv.3_Intron|ZBTB10_uc003ybw.3_Missense_Mutation_p.P239H|ZBTB10_uc010lzt.2_Missense_Mutation_p.P239H	NM_001105539	NP_001099009	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10 isoform	239					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)	1	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			CTCGCGCGGCCCAAGTCTCTA	0.423			NA											8	8					0.00307968	0.00507241	0.00308	1	0
CA1	759	broad.mit.edu	37	8	86249258	86249258	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:86249258C>G	uc003ydh.2	-	5	470	c.270G>C	c.(268-270)AGG>AGC	p.R90S	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.R90S|CA1_uc003ydi.2_Missense_Mutation_p.R90S	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	90					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	ACTGAAAGAGCCTGTAGCTGT	0.423			NA											72	106					0	0	0.01441	0	0
RUNX1T1	862	broad.mit.edu	37	8	93003958	93003958	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:93003958G>T	uc003yfd.2	-	6	984	c.900C>A	c.(898-900)TAC>TAA	p.Y300*	RUNX1T1_uc003yfc.1_Nonsense_Mutation_p.Y273*|RUNX1T1_uc003yfe.1_Nonsense_Mutation_p.Y263*|RUNX1T1_uc010mao.2_Nonsense_Mutation_p.Y273*|RUNX1T1_uc011lgi.1_Nonsense_Mutation_p.Y311*|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Nonsense_Mutation_p.Y263*	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	300					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CATCCAAACGGTAATGCTGAG	0.557			NA											74	127					1.88737e-50	5.09685e-50	0.01441	1	0
CCNE2	9134	broad.mit.edu	37	8	95897326	95897326	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:95897326T>A	uc003yhc.2	-	9	909	c.800A>T	c.(799-801)TAT>TTT	p.Y267F	CCNE2_uc003yhd.2_Missense_Mutation_p.Y267F	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	267					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					TTCCTGAGAATACTGAGGTAG	0.323			NA											22	74					0	0	0.012319	0	0
PTDSS1	9791	broad.mit.edu	37	8	97311923	97311924	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:97311923_97311924TC>AA	uc003yht.1	+	6	704_705	c.602_603TC>AA	c.(601-603)CTC>CAA	p.L201Q	PTDSS1_uc003yhu.1_Missense_Mutation_p.L55Q	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	201	Helical; (Potential).				phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	GTTTCTCAGCTCTTCTTCATGC	0.436			NA											57	253					0	0	0.004672	0	0
PGCP	10404	broad.mit.edu	37	8	97797326	97797327	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:97797326_97797327GG>AA	uc003yhw.2	+	2	367_368	c.201_202GG>AA	c.(199-204)TTGGCA>TTAACA	p.A68T	PGCP_uc010mbe.2_Missense_Mutation_p.A68T	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	68					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					ATGAGCGATTGGCACTTCTGGT	0.436			NA											50	97					0	0	0.004672	0	0
CSMD3	114788	broad.mit.edu	37	8	113293408	113293408	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:113293408C>G	uc003ynu.2	-	59	9662	c.9503G>C	c.(9502-9504)TGT>TCT	p.C3168S	CSMD3_uc003yns.2_Missense_Mutation_p.C2370S|CSMD3_uc003ynt.2_Missense_Mutation_p.C3128S|CSMD3_uc011lhx.1_Missense_Mutation_p.C2999S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3168	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTACTTGTACAGTTAGGTAA	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	65					0	0	0.003954	0	0
CSMD3	114788	broad.mit.edu	37	8	113668416	113668416	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:113668416G>C	uc003ynu.2	-	18	3130	c.2971C>G	c.(2971-2973)CGT>GGT	p.R991G	CSMD3_uc003yns.2_Missense_Mutation_p.R263G|CSMD3_uc003ynt.2_Missense_Mutation_p.R951G|CSMD3_uc011lhx.1_Missense_Mutation_p.R887G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	991	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTATTGGAACGACTGTTGTCT	0.328			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	105					0	0	0.00623	0	0
ZFAT	57623	broad.mit.edu	37	8	135614646	135614646	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:135614646T>A	uc003yup.2	-	6	1491	c.1316A>T	c.(1315-1317)CAT>CTT	p.H439L	ZFAT_uc003yun.2_Missense_Mutation_p.H427L|ZFAT_uc003yuo.2_Missense_Mutation_p.H427L|ZFAT_uc010meh.2_Missense_Mutation_p.H427L|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.H427L|ZFAT_uc010mej.2_Missense_Mutation_p.H377L|ZFAT_uc003yur.2_Missense_Mutation_p.H427L	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	439	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGTGGCCCCATGGCCACAGAG	0.587			NA											19	88					0	0	0.008871	0	0
PYCRL	65263	broad.mit.edu	37	8	144687961	144687961	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:144687961A>T	uc003yyy.2	-	6	780	c.770T>A	c.(769-771)CTC>CAC	p.L257H	PYCRL_uc011lkm.1_Missense_Mutation_p.L237H|PYCRL_uc011lkn.1_RNA	NM_023078	NP_075566	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	245					proline biosynthetic process		pyrroline-5-carboxylate reductase activity				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CAGGGCGTGGAGTCCATAGAT	0.682			NA											19	104					0	0	0.010504	0	0
FAM83H	286077	broad.mit.edu	37	8	144808765	144808765	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:144808765T>A	uc003yzk.2	-	5	2935	c.2866A>T	c.(2866-2868)AGC>TGC	p.S956C	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	956					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ATGGGGCCGCTCGGCCCCTCC	0.711			NA											18	34					0	0	0.007413	0	0
EPPK1	83481	broad.mit.edu	37	8	144940476	144940476	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:144940476C>A	uc003zaa.1	-	2	14969	c.14956G>T	c.(14956-14958)GGG>TGG	p.G4986W		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4986	Plectin 63.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATCTGCTGCCCGGTGTAGGGG	0.706			NA											49	594					4.00472e-15	8.16287e-15	0.01441	1	0
CPSF1	29894	broad.mit.edu	37	8	145622562	145622562	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:145622562G>T	uc003zcj.2	-	23	2527	c.2452C>A	c.(2452-2454)CTT>ATT	p.L818I		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	818					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTGTCCACAAGGACCCGCTGC	0.662	NSCLC(133;1088 1848 27708 34777 35269)		NA											5	6					1.6384e-10	3.02649e-10	0.001984	1	0
MPDZ	8777	broad.mit.edu	37	9	13192152	13192152	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:13192152C>G	uc010mia.1	-	14	2003	c.1946G>C	c.(1945-1947)TGT>TCT	p.C649S	MPDZ_uc010mhy.2_Missense_Mutation_p.C649S|MPDZ_uc010mhz.2_Missense_Mutation_p.C649S|MPDZ_uc011lmn.1_Missense_Mutation_p.C649S|MPDZ_uc003zlb.3_Missense_Mutation_p.C649S	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	649					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CTCAATATCACATAAGTCCAG	0.378			NA											7	8					0	0	0.001984	0	0
BNC2	54796	broad.mit.edu	37	9	16727855	16727855	+	Silent	SNP	T	T	A	rs79432515		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:16727855T>A	uc003zml.2	-	3	410	c.270A>T	c.(268-270)CCA>CCT	p.P90P	BNC2_uc011lmw.1_Intron|BNC2_uc003zmm.2_Silent_p.P48P|BNC2_uc003zmq.1_Silent_p.P104P|BNC2_uc003zmr.1_Silent_p.P90P|BNC2_uc003zmp.1_Silent_p.P90P|BNC2_uc010mij.1_Silent_p.P12P|BNC2_uc003zmu.1_RNA|BNC2_uc010mim.1_RNA|BNC2_uc010min.1_Intron|BNC2_uc003zmo.1_Silent_p.P12P	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CCATGAACCCTGGTTCAGCCG	0.343			NA											62	171					0	0	0.01441	0	0
PIGO	84720	broad.mit.edu	37	9	35095491	35095491	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:35095491G>A	uc003zwd.2	-	2	468	c.72C>T	c.(70-72)TTC>TTT	p.F24F	PIGO_uc003zwc.1_Silent_p.F24F|PIGO_uc003zwe.2_Silent_p.F24F|PIGO_uc003zwf.2_Silent_p.F24F|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	24	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGCCACTGGTGAAGAGGGCAA	0.582			NA											7	8					0	0	0.00308	0	0
ECM2	1842	broad.mit.edu	37	9	95284981	95284981	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:95284981C>T	uc004ash.2	-	2	233	c.168G>A	c.(166-168)CAG>CAA	p.Q56Q	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Silent_p.Q56Q|ECM2_uc011lty.1_Silent_p.Q56Q|ECM2_uc004asg.2_Silent_p.Q56Q|ECM2_uc011ltz.1_Silent_p.Q56Q|ECM2_uc004asi.2_Silent_p.Q56Q	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	56					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						CTGTTGTTTGCTGAATTCCAA	0.388			NA											75	78					0	0	0.01441	0	0
OR13C8	138802	broad.mit.edu	37	9	107331760	107331760	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:107331760T>A	uc011lvo.1	+	1	312	c.312T>A	c.(310-312)TCT>TCA	p.S104S		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTTTATTTCTTTTGCCATGG	0.483			NA											97	58					0	0	0.01441	0	0
FAM47A	158724	broad.mit.edu	37	X	34148697	34148697	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:34148697G>T	uc004ddg.2	-	1	1732	c.1699C>A	c.(1699-1701)CAT>AAT	p.H567N		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	567										ovary(4)|central_nervous_system(1)	5						GAGAATTGATGGGACTCTGGA	0.547			NA											63	16					7.73544e-29	1.82091e-28	0.01441	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913138	77913138	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:77913138A>G	uc004edc.1	-	2	1076	c.780T>C	c.(778-780)AGT>AGC	p.S260S		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	260							nucleic acid binding|zinc ion binding	p.S260T(1)		ovary(1)	1						CTCTCATGTAACTATACAGCT	0.507			NA											5	16					0	0	0.000602	0	0
CYLC1	1538	broad.mit.edu	37	X	83128348	83128348	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:83128348C>A	uc004eei.1	+	4	653	c.632C>A	c.(631-633)ACT>AAT	p.T211N	CYLC1_uc004eeh.1_Missense_Mutation_p.T210N	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	211					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AAGACAAACACTGAATTCCTA	0.308			NA											21	10					1.01871e-10	1.9016e-10	0.008871	1	0
GPR50	9248	broad.mit.edu	37	X	150349641	150349641	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:150349641C>A	uc010ntg.1	+	2	1721	c.1586C>A	c.(1585-1587)CCT>CAT	p.P529H		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	529	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					ACCAGCCACCCTAAGCCCACT	0.612			NA											89	25					2.39224e-78	6.84232e-78	0.01441	1	0
MAGEA12	4111	broad.mit.edu	37	X	151899994	151899994	+	Nonsense_Mutation	SNP	G	G	T	rs147399924	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:151899994G>T	uc010ntp.2	-	3	1161	c.807C>A	c.(805-807)TAC>TAA	p.Y269*	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Nonsense_Mutation_p.Y269*	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	269	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGGAACTCGTAGCATGCAG	0.542			NA											25	341					9.57634e-11	1.79388e-10	0.00333	1	0
DUSP9	1852	broad.mit.edu	37	X	152915633	152915633	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:152915633G>C	uc004fhx.3	+	4	1232	c.1028G>C	c.(1027-1029)AGC>ACC	p.S343T	DUSP9_uc004fhy.3_Missense_Mutation_p.S343T	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	343	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTTGAGCGCAGCTTGCGGCTG	0.602			NA											142	43					0	0	0.01441	0	0
MST1P9	11223	broad.mit.edu	37	1	17086085	17086086	+	Frame_Shift_Ins	INS	-	-	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:17086085_17086086insC	uc010ock.1	-	7	811_812	c.811_812insG	c.(811-813)GCGfs	p.A271fs	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						GGCAAGGTACGCCGCGGTGGTG	0.649			NA											3	4	---	---	---	---	NA	NA	NA	NA	NA
PPFIBP2	8495	broad.mit.edu	37	11	7661015	7661020	+	In_Frame_Del	DEL	CAGGAG	CAGGAG	-	rs137855547	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	CAGGAG	CAGGAG	-	-	CAGGAG	CAGGAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:7661015_7661020delCAGGAG	uc001mfj.3	+	15	1677_1682	c.1289_1294delCAGGAG	c.(1288-1296)TCAGGAGCC>TCC	p.GA431del	PPFIBP2_uc010rbb.1_In_Frame_Del_p.GA354del|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_In_Frame_Del_p.GA354del|PPFIBP2_uc010rbd.1_In_Frame_Del_p.GA273del|PPFIBP2_uc010rbe.1_In_Frame_Del_p.GA319del|PPFIBP2_uc001mfl.3_In_Frame_Del_p.GA288del|PPFIBP2_uc009yfj.1_In_Frame_Del_p.GA75del	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	431_432					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GGGAAGCTTTCAGGAGCCACGCCCAA	0.568			NA											53	245	---	---	---	---	NA	NA	NA	NA	NA
LRRIQ1	84125	broad.mit.edu	37	12	85449548	85449549	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:85449548_85449549insA	uc001tac.2	+	8	1088_1089	c.977_978insA	c.(976-978)GCAfs	p.A326fs	LRRIQ1_uc001tab.1_Frame_Shift_Ins_p.A326fs|LRRIQ1_uc001taa.1_Frame_Shift_Ins_p.A301fs	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	326	Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		gaaaaggaagcaaaaatacgac	0.084			NA											17	59	---	---	---	---	NA	NA	NA	NA	NA
CHRNA3	1136	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs66793222		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	CAG	CAG	-	-	CAG	CAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:78913068_78913070delCAG	uc002bec.2	-	1	253_255	c.67_69delCTG	c.(67-69)CTGdel	p.L23del	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_In_Frame_Del_p.L23del	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						gcagcagagacagcagcagcagc	0.601			NA											4	3	---	---	---	---	NA	NA	NA	NA	NA
LASS3	204219	broad.mit.edu	37	15	101013174	101013174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:101013174delC	uc002bvz.2	-	10	1195	c.693delG	c.(691-693)GGGfs	p.G231fs	LASS3_uc002bwa.2_Frame_Shift_Del_p.G242fs|LASS3_uc002bwb.2_Frame_Shift_Del_p.G231fs	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	231	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			TCACGAGGGTCCCACTGCGAA	0.433	NSCLC(135;1149 2482 10680 49908)		NA											24	129	---	---	---	---	NA	NA	NA	NA	NA
MPP3	4356	broad.mit.edu	37	17	41905182	41905182	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:41905182delC	uc002iei.3	-	8	626	c.460delG	c.(460-462)GACfs	p.D154fs	MPP3_uc002ieh.2_Frame_Shift_Del_p.D179fs|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Frame_Shift_Del_p.D154fs|MPP3_uc010wik.1_Frame_Shift_Del_p.D179fs	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	154	PDZ.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GAGTGCTCGTCCCGCCGGATG	0.627			NA											41	156	---	---	---	---	NA	NA	NA	NA	NA
ATP9B	374868	broad.mit.edu	37	18	77102279	77102289	+	Frame_Shift_Del	DEL	AACAGGCGATA	AACAGGCGATA	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	AACAGGCGATA	AACAGGCGATA	-	-	AACAGGCGATA	AACAGGCGATA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:77102279_77102289delAACAGGCGATA	uc002lmx.2	+	20	2309_2319	c.2295_2305delAACAGGCGATA	c.(2293-2307)CTAACAGGCGATAAAfs	p.L765fs	ATP9B_uc002lmw.1_Frame_Shift_Del_p.L765fs|ATP9B_uc002lmz.1_Frame_Shift_Del_p.L459fs|ATP9B_uc002lna.2_5'Flank	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	765_769	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TATGGATGCTAACAGGCGATAAACTCGAGAC	0.28			NA											16	124	---	---	---	---	NA	NA	NA	NA	NA
SPRED2	200734	broad.mit.edu	37	2	65540928	65540928	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:65540928delG	uc002sdr.3	-	6	1499	c.964delC	c.(964-966)CGCfs	p.R322fs	SPRED2_uc010fcw.2_Frame_Shift_Del_p.R319fs	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	322	SPR.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TGGCCCCGGCGGTTCTCCTCG	0.662			NA											94	260	---	---	---	---	NA	NA	NA	NA	NA
EYA2	2139	broad.mit.edu	37	20	45808534	45808535	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:45808534_45808535insA	uc002xsm.2	+	13	1661_1662	c.1287_1288insA	c.(1285-1290)CTGAAGfs	p.L429fs	EYA2_uc010ghp.2_Intron|EYA2_uc002xsn.2_Frame_Shift_Ins_p.L434fs|EYA2_uc002xso.2_Frame_Shift_Ins_p.L429fs|EYA2_uc002xsp.2_Frame_Shift_Ins_p.L429fs|EYA2_uc002xsq.2_Frame_Shift_Ins_p.L399fs	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	429_430					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				CCCACTCCCTGAAGGCACTAAA	0.559	Pancreas(120;56 1725 18501 25218 43520)		NA											47	64	---	---	---	---	NA	NA	NA	NA	NA
YTHDC1	91746	broad.mit.edu	37	4	69199072	69199073	+	Frame_Shift_Ins	INS	-	-	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:69199072_69199073insG	uc003hdx.2	-	5	1279_1280	c.926_927insC	c.(925-927)CCAfs	p.P309fs	YTHDC1_uc003hdy.2_Frame_Shift_Ins_p.P309fs	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	309										upper_aerodigestive_tract(1)|ovary(1)	2						CAAAAACAATTGGAGATATGCC	0.332			NA											75	260	---	---	---	---	NA	NA	NA	NA	NA
RICTOR	253260	broad.mit.edu	37	5	38959321	38959325	+	Frame_Shift_Del	DEL	GGAAA	GGAAA	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08	GGAAA	GGAAA	-	-	GGAAA	GGAAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:38959321_38959325delGGAAA	uc003jlp.2	-	22	2174_2178	c.2150_2154delTTTCC	c.(2149-2154)CTTTCCfs	p.L717fs	RICTOR_uc003jlo.2_Frame_Shift_Del_p.L717fs|RICTOR_uc010ivf.2_Frame_Shift_Del_p.L432fs	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	717_718					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTAAAATTTTGGAAAGGATGACTCT	0.337			NA											8	109	---	---	---	---	NA	NA	NA	NA	NA
