Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HSPG2	3339	broad.mit.edu	37	1	22173050	22173050	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:22173050G>C	uc001bfj.2	-	63	8247	c.8207C>G	c.(8206-8208)TCA>TGA	p.S2736*	HSPG2_uc009vqd.2_Nonsense_Mutation_p.S2737*	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2736	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGCCACGTGTGAGGAGGATGA	0.622			NA											4	98					0	0	0.009096	0	0
ZBTB40	9923	broad.mit.edu	37	1	22817950	22817950	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:22817950C>G	uc001bft.2	+	4	1266	c.755C>G	c.(754-756)TCA>TGA	p.S252*	ZBTB40_uc001bfu.2_Nonsense_Mutation_p.S252*|ZBTB40_uc009vqi.1_Nonsense_Mutation_p.S252*	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	252					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GGTGTCTTCTCAGATGCACTC	0.348			NA											9	75					0	0	0.000978	0	0
ZBTB40	9923	broad.mit.edu	37	1	22818015	22818015	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:22818015C>T	uc001bft.2	+	4	1331	c.820C>T	c.(820-822)CCA>TCA	p.P274S	ZBTB40_uc001bfu.2_Missense_Mutation_p.P274S|ZBTB40_uc009vqi.1_Missense_Mutation_p.P274S	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	274					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AATTAAAGGTCCACAGAAGGA	0.383			NA											4	55					0	0	0.001168	0	0
PAFAH2	5051	broad.mit.edu	37	1	26299085	26299085	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:26299085C>T	uc001bld.3	-	10	1228	c.1048G>A	c.(1048-1050)GTA>ATA	p.V350I	PAFAH2_uc001ble.3_Missense_Mutation_p.V350I	NM_000437	NP_000428	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2	350					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			ovary(2)	2		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		ATGGCCCGTACCATAACCTCC	0.527			NA											10	77					0	0	0.006214	0	0
TRIM63	84676	broad.mit.edu	37	1	26387753	26387753	+	Silent	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:26387753G>C	uc001bli.1	-	3	541	c.405C>G	c.(403-405)CTC>CTG	p.L135L		NM_032588	NP_115977	Q969Q1	TRI63_HUMAN	muscle specific ring finger protein 1	135	Interaction with TTN.|B box-type.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCACACGTGAGACAGTAGA	0.552			NA											6	72					0	0	0.00308	0	0
ZMYM6	9204	broad.mit.edu	37	1	35477597	35477597	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:35477597A>G	uc001byh.2	-	8	1184	c.956T>C	c.(955-957)GTT>GCT	p.V319A	ZMYM6_uc001byf.1_Missense_Mutation_p.V319A|ZMYM6_uc010oht.1_Missense_Mutation_p.V222A|ZMYM6_uc009vup.2_Missense_Mutation_p.V125A|ZMYM6_uc009vuq.1_Missense_Mutation_p.V319A|ZMYM6_uc009vur.1_Missense_Mutation_p.V125A	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	319	MYM-type 4.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				ATGACATGAAACCTGGACACC	0.343			NA											11	52					0	0	0.008291	0	0
COL8A2	1296	broad.mit.edu	37	1	36564747	36564747	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:36564747C>G	uc001bzv.1	-	2	542	c.535G>C	c.(535-537)GGG>CGG	p.G179R	COL8A2_uc001bzw.1_Missense_Mutation_p.G114R	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	179	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCTGGCACCCCTTGGGCACCT	0.697			NA											9	15					0	0	0.004482	0	0
B4GALT2	8704	broad.mit.edu	37	1	44447061	44447061	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:44447061T>C	uc001clg.2	+	2	599	c.229T>C	c.(229-231)TCC>CCC	p.S77P	B4GALT2_uc001clh.2_Silent_p.A25A|B4GALT2_uc010okl.1_Missense_Mutation_p.S106P|B4GALT2_uc001cli.2_Missense_Mutation_p.S77P	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	77	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CGCCTCTAGCTCCGGGCTCCC	0.632			NA											4	70					0	0	0.000602	0	0
F3	2152	broad.mit.edu	37	1	94998772	94998772	+	Silent	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:94998772C>G	uc001dqr.2	-	4	644	c.465G>C	c.(463-465)GTG>GTC	p.V155V	F3_uc001dqp.2_RNA|F3_uc001dqq.2_RNA|F3_uc001dqs.2_Silent_p.V155V	NM_001993	NP_001984	P13726	TF_HUMAN	coagulation factor III precursor	155	Extracellular (Potential).				activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			central_nervous_system(1)	1		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	CGGTCACATTCACTTTTGTTC	0.403	Melanoma(40;358 1339 15970 39161)		NA											23	18					0	0	0.002299	0	0
LPPR4	9890	broad.mit.edu	37	1	99771934	99771934	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:99771934C>G	uc001dse.2	+	7	1766	c.1660C>G	c.(1660-1662)CGG>GGG	p.R554G	LPPR4_uc010oue.1_Missense_Mutation_p.R496G	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	554							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CAGCTCTGCTCGGGCCAAGTG	0.537			NA											13	139					0	0	0.00245	0	0
LINGO4	339398	broad.mit.edu	37	1	151773522	151773522	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:151773522C>T	uc001ezf.1	-	2	1849	c.1659G>A	c.(1657-1659)CTG>CTA	p.L553L		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	553	Helical; (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AAAGGGCAATCAGGCCAAAGC	0.562			NA											9	309					0	0	0.006214	0	0
FDPS	2224	broad.mit.edu	37	1	155288031	155288031	+	Silent	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:155288031C>G	uc001fkc.2	+	6	852	c.633C>G	c.(631-633)CTC>CTG	p.L211L	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Silent_p.L145L|FDPS_uc001fke.2_Silent_p.L211L|FDPS_uc001fkf.2_Silent_p.L145L|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	211					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	TGCTGAAGCTCTATTGCCGGG	0.542			NA											7	143					0	0	0.00308	0	0
CD1A	909	broad.mit.edu	37	1	158225110	158225110	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:158225110C>A	uc001frt.2	+	2	828	c.295C>A	c.(295-297)CGT>AGT	p.R99S		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	99	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TGAGGGAATTCGTAGATACGC	0.468			NA											7	86					2.0095e-06	2.17542e-06	0.001984	1	0
CD1B	910	broad.mit.edu	37	1	158300725	158300725	+	Silent	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:158300725G>T	uc001frx.2	-	2	297	c.189C>A	c.(187-189)GGC>GGA	p.G63G	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Silent_p.G63G	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	63	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					ATATGGCAGTGCCTGAGTCGC	0.468			NA											125	362					4.43683e-73	5.54017e-73	0.00361	1	0
ARHGAP30	257106	broad.mit.edu	37	1	161018914	161018914	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:161018914G>A	uc001fxl.2	-	12	2243	c.1897C>T	c.(1897-1899)CTG>TTG	p.L633L	ARHGAP30_uc001fxk.2_Silent_p.L633L|ARHGAP30_uc001fxm.2_Silent_p.L479L|ARHGAP30_uc009wtx.2_Silent_p.L306L|ARHGAP30_uc001fxn.1_Silent_p.L479L	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	633					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TCTCCCTCCAGACTCCCTGAA	0.577			NA											27	266					0	0	0.00632	0	0
CENPL	91687	broad.mit.edu	37	1	173772523	173772523	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:173772523G>C	uc001gje.3	-	4	755	c.541C>G	c.(541-543)CTG>GTG	p.L181V	CENPL_uc009wwg.2_Missense_Mutation_p.L55V|CENPL_uc001gjg.3_Missense_Mutation_p.L227V|CENPL_uc001gjf.3_Missense_Mutation_p.L181V	NM_033319	NP_201576	Q8N0S6	CENPL_HUMAN	centromere protein L isoform 2	181					mitotic prometaphase	chromosome, centromeric region|cytosol|nucleus					0						AATAAGGGCAGACAGGTGAAA	0.423			NA											5	177					0	0	0.000602	0	0
TNR	7143	broad.mit.edu	37	1	175334287	175334287	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:175334287C>T	uc001gkp.1	-	10	2527	c.2446G>A	c.(2446-2448)GAG>AAG	p.E816K	TNR_uc009wwu.1_Missense_Mutation_p.E816K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	816	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCATCATCTCTTCCTCCTCA	0.532			NA											25	91					0	0	0.004656	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885798	180885798	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:180885798C>A	uc001gok.2	+	2	626	c.559C>A	c.(559-561)CCT>ACT	p.P187T		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	187										ovary(3)|skin(1)	4						GAGCCCGTGGCCTCCAGAAGC	0.647			NA											42	117					5.20837e-25	6.30346e-25	0.00874	1	0
FCAMR	83953	broad.mit.edu	37	1	207143467	207143467	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:207143467C>T	uc001hfa.3	-	1	504	c.4G>A	c.(4-6)GAT>AAT	p.D2N	FCAMR_uc001hfb.2_Missense_Mutation_p.D2N|FCAMR_uc009xca.1_Missense_Mutation_p.D2N|FCAMR_uc001hfc.2_Missense_Mutation_p.D2N	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	Error:Variant_position_missing_in_Q8WWV6_after_alignment						integral to membrane|plasma membrane	receptor activity			ovary(1)	1						GCCTCTCCATCCATCTCAGTC	0.493	Ovarian(199;1883 2142 16966 44409 45154)		NA											7	115					0	0	0.00308	0	0
CENPF	1063	broad.mit.edu	37	1	214818019	214818019	+	Silent	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:214818019C>G	uc001hkm.2	+	13	5280	c.5106C>G	c.(5104-5106)CTC>CTG	p.L1702L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1798					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGCAGGACCTCAATCTAGACA	0.438	Colon(80;575 1284 11000 14801 43496)		NA											4	82					0	0	0.009096	0	0
OBSCN	84033	broad.mit.edu	37	1	228466505	228466505	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr1:228466505C>T	uc009xez.1	+	26	7019	c.6975C>T	c.(6973-6975)GGC>GGT	p.G2325G	OBSCN_uc001hsn.2_Silent_p.G2325G|OBSCN_uc001hsp.1_Silent_p.G24G|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2325	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGTTCAAGGGCAGTCAGGAGC	0.642			NA											17	68					0	0	0.00499	0	0
RBM17	84991	broad.mit.edu	37	10	6157223	6157223	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:6157223G>A	uc001ijb.2	+	11	1277	c.1051G>A	c.(1051-1053)GAA>AAA	p.E351K	RBM17_uc010qav.1_Missense_Mutation_p.E351K|RBM17_uc001ijc.2_RNA	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	351	RRM.				mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						CCCTGATGATGAAGCAGTACG	0.338			NA											3	25					0	0	0.004672	0	0
NEBL	10529	broad.mit.edu	37	10	21120446	21120446	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:21120446G>C	uc001iqi.2	-	15	1913	c.1516C>G	c.(1516-1518)CTT>GTT	p.L506V	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	506	Nebulin 14.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TGGACATCAAGAGTGTCTGTG	0.423			NA											5	94					0	0	0.001168	0	0
ANUBL1	93550	broad.mit.edu	37	10	46122313	46122313	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:46122313C>G	uc001jcp.3	-	7	1200	c.958G>C	c.(958-960)GAT>CAT	p.D320H	ANUBL1_uc001jcl.3_5'UTR|ANUBL1_uc001jcm.3_Missense_Mutation_p.D320H|ANUBL1_uc009xmu.2_Missense_Mutation_p.D246H|ANUBL1_uc001jcn.3_Missense_Mutation_p.D246H|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	320							zinc ion binding				0						CAGCTATTATCTTCCTTAAGA	0.433			NA											7	56					0	0	0.001984	0	0
AGAP6	414189	broad.mit.edu	37	10	51768776	51768776	+	Silent	SNP	G	G	T	rs77193201		TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:51768776G>T	uc001jix.3	+	8	1289	c.891G>T	c.(889-891)CTG>CTT	p.L297L		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	297					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						GGAAATGGCTGAAGACATGGA	0.438			NA											12	481					1.36491e-13	1.61059e-13	0.001855	1	0
UNC5B	219699	broad.mit.edu	37	10	73056370	73056370	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:73056370G>A	uc001jro.2	+	15	2806	c.2361G>A	c.(2359-2361)CAG>CAA	p.Q787Q	UNC5B_uc001jrp.2_Silent_p.Q776Q	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	787	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GTGGCAGCCAGAAGGCCCTCC	0.607			NA											3	57					0	0	0.009096	0	0
DLG5	9231	broad.mit.edu	37	10	79580869	79580869	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:79580869G>C	uc001jzk.2	-	15	3443	c.3373C>G	c.(3373-3375)CCA>GCA	p.P1125A	DLG5_uc001jzi.2_5'Flank|DLG5_uc001jzj.2_Intron|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.P729A	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1125					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ATCACTACTGGAGCAAGCTTC	0.597			NA											5	79					0	0	0.000602	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97388160	97388160	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:97388160T>A	uc001kkz.2	-	8	1140	c.898A>T	c.(898-900)AAG>TAG	p.K300*	ALDH18A1_uc001kky.2_Nonsense_Mutation_p.K298*|ALDH18A1_uc010qog.1_Nonsense_Mutation_p.K189*|ALDH18A1_uc010qoh.1_Nonsense_Mutation_p.K88*	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	300	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	ACTCTAGACTTGGTTCCAAAT	0.408			NA											48	86					0	0	0.00361	0	0
C10orf28	27291	broad.mit.edu	37	10	99968718	99968718	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:99968718G>C	uc001kow.3	+	4	1142	c.847G>C	c.(847-849)GAT>CAT	p.D283H	C10orf28_uc001kox.3_Missense_Mutation_p.D283H|C10orf28_uc001koy.3_Missense_Mutation_p.D283H|C10orf28_uc009xvx.2_Missense_Mutation_p.D283H|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	283							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		AACTTGCGTAGATTTTGAAGT	0.423			NA											16	67					0	0	0.003163	0	0
C10orf28	27291	broad.mit.edu	37	10	99968962	99968962	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:99968962G>C	uc001kow.3	+	4	1386	c.1091G>C	c.(1090-1092)GGA>GCA	p.G364A	C10orf28_uc001kox.3_Missense_Mutation_p.G364A|C10orf28_uc001koy.3_Missense_Mutation_p.G364A|C10orf28_uc009xvx.2_Missense_Mutation_p.G364A|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	364							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		AGAGATAGTGGATTTAAGAAT	0.398			NA											23	113					0	0	0.00278	0	0
HIF1AN	55662	broad.mit.edu	37	10	102300398	102300398	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:102300398C>A	uc001krj.3	+	3	511	c.436C>A	c.(436-438)CTG>ATG	p.L146M		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	146	JmjC.|Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		TAGGTTGTATCTGCAGCAAAC	0.463			NA											7	184					1.06961e-07	1.18511e-07	0.00308	1	0
SORCS3	22986	broad.mit.edu	37	10	106802863	106802863	+	Silent	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:106802863C>G	uc001kyi.1	+	5	1232	c.1005C>G	c.(1003-1005)CGC>CGG	p.R335R		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	335	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGCATGAACGCATCACACCCA	0.453	NSCLC(116;1497 1690 7108 13108 14106)		NA											73	116					0	0	0.00361	0	0
PRLHR	2834	broad.mit.edu	37	10	120354367	120354367	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr10:120354367G>A	uc001ldp.1	-	2	529	c.390C>T	c.(388-390)GGC>GGT	p.G130G		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	130	Helical; Name=3; (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		ACAGGCCGCCGCCGAACACCC	0.657			NA											15	36					0	0	0.004007	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409829	56409829	+	Silent	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:56409829T>A	uc001njb.1	-	1	87	c.87A>T	c.(85-87)CTA>CTT	p.L29L		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	29	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						GGACTCCTTGTAGATCTGGAT	0.398			NA											8	41					0	0	0.00308	0	0
AHNAK	79026	broad.mit.edu	37	11	62286885	62286885	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:62286885C>A	uc001ntl.2	-	5	15304	c.15004G>T	c.(15004-15006)GAG>TAG	p.E5002*	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5002					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGCTCTGCCTCAGGAACAGTG	0.413			NA											25	97					9.90768e-06	1.06282e-05	0.004656	1	0
HRASLS2	54979	broad.mit.edu	37	11	63325879	63325879	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:63325879G>A	uc001nxg.1	-	3	431	c.372C>T	c.(370-372)GTC>GTT	p.V124V		NM_017878	NP_060348	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	124					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity				0						CACTGCGGGAGACGCCATAGC	0.622			NA											3	56					0	0	0.004672	0	0
CATSPER1	117144	broad.mit.edu	37	11	65790439	65790439	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:65790439C>T	uc001ogt.2	-	2	1448	c.1310G>A	c.(1309-1311)CGG>CAG	p.R437Q		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	437	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GATCATTTCCCGGAAGCCCTG	0.552			NA									OREG0021092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	79					0	0	0.00278	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238423	71238423	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:71238423C>T	uc001oqq.1	+	1	111	c.77C>T	c.(76-78)TCT>TTT	p.S26F		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	26						keratin filament					0						GGCTGTGGCTCTGGCTGTGGG	0.667			NA											10	294					0	0	0.000978	0	0
INTS4	92105	broad.mit.edu	37	11	77705651	77705651	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:77705651G>A	uc001oys.2	-	1	67	c.39C>T	c.(37-39)TTC>TTT	p.F13F	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Silent_p.F13F|INTS4_uc001oyv.1_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	13					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CCACTTTCGTGAATTCCTCAT	0.582			NA											21	98					0	0	0.00278	0	0
FAT3	120114	broad.mit.edu	37	11	92087428	92087428	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:92087428C>G	uc001pdj.3	+	1	2167	c.2150C>G	c.(2149-2151)TCA>TGA	p.S717*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	717	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACTTTTATTCAATTAATAGA	0.398			NA								TCGA Ovarian(4;0.039)			8	162					0	0	0.004482	0	0
FAT3	120114	broad.mit.edu	37	11	92531712	92531712	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:92531712G>T	uc001pdj.3	+	9	5550	c.5533G>T	c.(5533-5535)GCC>TCC	p.A1845S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1845	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAACCATTGCCCATTTCCA	0.458			NA								TCGA Ovarian(4;0.039)			17	24					3.41278e-10	3.90979e-10	0.00499	1	0
OR10G8	219869	broad.mit.edu	37	11	123901033	123901033	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:123901033G>C	uc001pzp.1	+	1	704	c.704G>C	c.(703-705)AGA>ACA	p.R235T		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GGGAAGCACAGAGCCTTTCAG	0.547			NA											28	85					0	0	0.008361	0	0
CDON	50937	broad.mit.edu	37	11	125887079	125887079	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:125887079C>T	uc009zbw.2	-	6	960	c.832G>A	c.(832-834)GAT>AAT	p.D278N	CDON_uc001qdc.3_Missense_Mutation_p.D278N|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.D278N	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	278	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TCAACGCTATCAGTGGCAAGA	0.498			NA											29	51					0	0	0.00632	0	0
WNK1	65125	broad.mit.edu	37	12	968524	968524	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:968524G>T	uc001qio.3	+	6	2021	c.1514G>T	c.(1513-1515)CGT>CTT	p.R505L	WNK1_uc001qip.3_Missense_Mutation_p.R505L|WNK1_uc001qir.3_5'Flank	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	505					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TTATGGCTACGTATTGAAGAT	0.348	Colon(19;451 567 6672 12618 28860)		NA											14	83					1.3612e-06	1.48039e-06	0.003163	1	0
LRRC23	10233	broad.mit.edu	37	12	7014909	7014909	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:7014909G>C	uc001qrt.3	+	2	504	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	LRRC23_uc001qrn.1_Missense_Mutation_p.E38Q|LRRC23_uc009zfg.2_Intron|LRRC23_uc001qrp.2_Missense_Mutation_p.E38Q|LRRC23_uc001qrq.2_Missense_Mutation_p.E38Q|LRRC23_uc001qrr.2_Missense_Mutation_p.K23N|LRRC23_uc001qrs.2_Missense_Mutation_p.K23N|LRRC23_uc009zfh.2_Missense_Mutation_p.E38Q	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	38										ovary(1)	1						agagggggaagagTTCCCTGA	0.378			NA											15	59					0	0	0.004007	0	0
FOXJ2	55810	broad.mit.edu	37	12	8192436	8192436	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:8192436C>T	uc001qtu.2	+	2	1093	c.8C>T	c.(7-9)TCT>TTT	p.S3F	FOXJ2_uc001qtt.1_Missense_Mutation_p.S3F	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	3					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		ACCATGGCTTCTGACCTAGAG	0.522			NA											12	121					0	0	0.000978	0	0
GUCY2C	2984	broad.mit.edu	37	12	14774061	14774061	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:14774061G>A	uc001rcd.2	-	23	2828	c.2691C>T	c.(2689-2691)GCC>GCT	p.A897A		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	897	Cytoplasmic (Potential).|Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						GGATTTCCAAGGCCATCTTGG	0.498			NA											21	69					0	0	0.001882	0	0
HOXC5	3222	broad.mit.edu	37	12	54428155	54428155	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:54428155G>A	uc001sew.2	+	2	623	c.548G>A	c.(547-549)CGC>CAC	p.R183H	HOXC5_uc001set.2_RNA|HOXC4_uc001seu.2_Intron	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	183	Homeobox.				regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCACTCGCCGCAGGCGCATA	0.512			NA											16	77					0	0	0.003163	0	0
SMARCC2	6601	broad.mit.edu	37	12	56563471	56563471	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:56563471C>G	uc001skb.2	-	24	2570	c.2464G>C	c.(2464-2466)GAG>CAG	p.E822Q	SMARCC2_uc001skd.2_Missense_Mutation_p.E853Q|SMARCC2_uc001ska.2_Missense_Mutation_p.E853Q|SMARCC2_uc001skc.2_Missense_Mutation_p.E852Q|SMARCC2_uc010sqf.1_Missense_Mutation_p.E742Q	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	822	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			ttctccttctcAGGATCGACT	0.323			NA											5	61					0	0	0.000602	0	0
C12orf12	196477	broad.mit.edu	37	12	91347524	91347524	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:91347524C>G	uc001tbj.2	-	1	1430	c.996G>C	c.(994-996)GAG>GAC	p.E332D		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	332	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						ccagctcctcctctccctcct	0.174			NA											22	30					0	0	0.001882	0	0
CKAP4	10970	broad.mit.edu	37	12	106632898	106632898	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:106632898C>T	uc001tlk.2	-	2	1797	c.1713G>A	c.(1711-1713)GAG>GAA	p.E571E		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	571	Potential.					ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						CCAGATTGTTCTCGTTGGTTT	0.448			NA											7	184					0	0	0.001984	0	0
ATP2A2	488	broad.mit.edu	37	12	110777138	110777138	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:110777138G>A	uc001tqk.3	+	12	2035	c.1472G>A	c.(1471-1473)AGA>AAA	p.R491K	ATP2A2_uc001tql.3_Missense_Mutation_p.R491K|ATP2A2_uc010sxy.1_Missense_Mutation_p.R464K	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	491	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TCACGTGACAGAAAGTCAATG	0.388			NA											8	39					0	0	0.00308	0	0
CIT	11113	broad.mit.edu	37	12	120128116	120128116	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:120128116C>A	uc001txi.1	-	46	5953	c.5900G>T	c.(5899-5901)CGC>CTC	p.R1967L	CIT_uc001txh.1_Missense_Mutation_p.R1485L|CIT_uc001txj.1_Missense_Mutation_p.R2009L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1967					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTTGTCCCTGCGCAGCTCGGT	0.726			NA											4	30					0.00909568	0.0094563	0.009096	1	0
EP400	57634	broad.mit.edu	37	12	132547172	132547172	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:132547172C>T	uc001ujn.2	+	46	8295	c.8260C>T	c.(8260-8262)CAG>TAG	p.Q2754*	EP400_uc001ujl.2_Nonsense_Mutation_p.Q2753*|EP400_uc001ujm.2_Nonsense_Mutation_p.Q2673*|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2790					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GACGACCTCTCAGGTGCAAGT	0.343			NA											14	60					0	0	0.00245	0	0
COG3	83548	broad.mit.edu	37	13	46054293	46054293	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr13:46054293G>A	uc001vak.2	+	4	518	c.417G>A	c.(415-417)GAG>GAA	p.E139E	COG3_uc010tfu.1_RNA|COG3_uc001vai.2_Silent_p.E139E|COG3_uc001vaj.1_Silent_p.E139E|COG3_uc010tfv.1_Intron|COG3_uc010aci.2_Intron	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	139					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		GGTTTCAGGAGCAGTGTGATG	0.398	Ovarian(150;1048 1859 18083 21577 42700)		NA											14	37					0	0	0.004007	0	0
LMO7	4008	broad.mit.edu	37	13	76287343	76287343	+	Missense_Mutation	SNP	C	C	A	rs75385907		TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr13:76287343C>A	uc010thv.1	+	3	1511	c.251C>A	c.(250-252)ACA>AAA	p.T84K	LMO7_uc001vjt.1_Missense_Mutation_p.T32K	NM_005358	NP_005349	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 1	84	CH.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AATTTTGAAACAAAAGATTTT	0.318			NA											6	31					1.26484e-09	1.44205e-09	0.00308	1	0
LAMP1	3916	broad.mit.edu	37	13	113975949	113975949	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr13:113975949G>T	uc001vtm.1	+	8	1302	c.1021G>T	c.(1021-1023)GAG>TAG	p.E341*	LAMP1_uc010tka.1_Nonsense_Mutation_p.E288*	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	341	Lumenal (Potential).|Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GTGCAACGCGGAGGAGCACGT	0.557			NA											18	95					2.35188e-11	2.7208e-11	0.006122	1	0
PPP2R5E	5529	broad.mit.edu	37	14	64006338	64006338	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr14:64006338G>A	uc001xgd.1	-	2	656	c.66C>T	c.(64-66)GTC>GTT	p.V22V	PPP2R5E_uc001xge.2_Silent_p.V22V|PPP2R5E_uc010tsh.1_Silent_p.V22V|PPP2R5E_uc001xgf.1_RNA|PPP2R5E_uc001xgg.3_Silent_p.V22V	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	22					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		TGGCTTTTCTGACGGACTTCC	0.463			NA											23	43					0	0	0.002299	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411807	105411807	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr14:105411807G>C	uc010axc.1	-	7	10101	c.9981C>G	c.(9979-9981)ATC>ATG	p.I3327M	AHNAK2_uc001ypx.2_Missense_Mutation_p.I3227M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3327						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGAGGCCTGGATGGACTTGC	0.602			NA											31	294					0	0	0.00361	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415472	105415472	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr14:105415472C>A	uc010axc.1	-	7	6436	c.6316G>T	c.(6316-6318)GAA>TAA	p.E2106*	AHNAK2_uc001ypx.2_Nonsense_Mutation_p.E2006*	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2106						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACTCTCATTTCCACCTTGGGG	0.592			NA											122	48					1.64933e-60	2.04865e-60	0.00361	1	0
APBA2	321	broad.mit.edu	37	15	29346847	29346847	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:29346847C>A	uc001zck.2	+	3	967	c.760C>A	c.(760-762)CCT>ACT	p.P254T	APBA2_uc010azj.2_Missense_Mutation_p.P254T|APBA2_uc010uat.1_Missense_Mutation_p.P254T|APBA2_uc001zcl.2_Missense_Mutation_p.P254T|APBA2_uc010uas.1_Missense_Mutation_p.P254T	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	254	STXBP1-binding.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CGAGCATGGGCCTGAGCCAGG	0.637			NA											30	58					4.34311e-12	5.07412e-12	0.003271	1	0
RPAP1	26015	broad.mit.edu	37	15	41812941	41812941	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:41812941C>A	uc001zod.2	-	22	3567	c.3443G>T	c.(3442-3444)TGG>TTG	p.W1148L	RPAP1_uc001zoc.2_Missense_Mutation_p.W167L	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1148	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGGCACAGCCCAGAGAGCCTG	0.657			NA											36	63					2.04263e-09	2.30651e-09	0.004289	1	0
LRRC57	255252	broad.mit.edu	37	15	42840407	42840407	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:42840407G>A	uc001zqd.1	-	2	488	c.120C>T	c.(118-120)CTC>CTT	p.L40L	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Silent_p.L40L	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	40	LRR 1.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		CGATGGTCCTGAGATTGCTCG	0.552			NA											5	163					0	0	0.001168	0	0
NEDD4	4734	broad.mit.edu	37	15	56126273	56126273	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:56126273T>C	uc002adj.2	-	22	3950	c.3650A>G	c.(3649-3651)TAC>TGC	p.Y1217C	NEDD4_uc002adl.2_Missense_Mutation_p.Y798C|NEDD4_uc002adi.2_Missense_Mutation_p.Y1145C|NEDD4_uc010ugj.1_Missense_Mutation_p.Y1201C|NEDD4_uc010bfm.2_Missense_Mutation_p.Y1200C|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1217	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		ATTTGCACTGTAGCCATTTTT	0.318			NA											35	64					0	0	0.003755	0	0
VPS13C	54832	broad.mit.edu	37	15	62211643	62211643	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:62211643G>C	uc002agz.2	-	58	7557	c.7483C>G	c.(7483-7485)CAT>GAT	p.H2495D	VPS13C_uc002aha.2_Missense_Mutation_p.H2452D|VPS13C_uc002ahb.1_Missense_Mutation_p.H2495D|VPS13C_uc002ahc.1_Missense_Mutation_p.H2452D|VPS13C_uc002ahd.1_5'Flank	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2495					protein localization					ovary(2)	2						GTATATCCATGAGGTACTAAG	0.378			NA											23	112					0	0	0.00278	0	0
UACA	55075	broad.mit.edu	37	15	70968880	70968880	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:70968880T>A	uc002asr.2	-	13	1187	c.1083A>T	c.(1081-1083)GAA>GAT	p.E361D	UACA_uc010uke.1_Missense_Mutation_p.E252D|UACA_uc002asq.2_Missense_Mutation_p.E348D|UACA_uc010bin.1_Missense_Mutation_p.E336D	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	361	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TCCTTAAGCTTTCTTCATGTT	0.289			NA											17	27					0	0	0.006122	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77329395	77329395	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:77329395G>A	uc002bcf.2	+	15	1579	c.1129G>A	c.(1129-1131)GAG>AAG	p.E377K	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010bku.1_Missense_Mutation_p.E368K|PSTPIP1_uc002bcg.2_Missense_Mutation_p.E374K|PSTPIP1_uc010bkw.1_Missense_Mutation_p.E358K|PSTPIP1_uc002bch.1_Missense_Mutation_p.E138K|PSTPIP1_uc002bci.1_RNA	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	377	SH3.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1						GAACCCAGATGAGCTGGACCT	0.637			NA											4	70					0	0	0.001168	0	0
HMG20A	10363	broad.mit.edu	37	15	77769946	77769946	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:77769946C>T	uc002bcr.2	+	8	866	c.665C>T	c.(664-666)ACA>ATA	p.T222I	HMG20A_uc002bcs.2_Missense_Mutation_p.T222I	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	222					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCTATATTTACAGAGGAATTC	0.333			NA											9	24					0	0	0.006214	0	0
AGBL1	123624	broad.mit.edu	37	15	86807741	86807741	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:86807741C>T	uc002blz.1	+	10	1281	c.1201C>T	c.(1201-1203)CTC>TTC	p.L401F	AGBL1_uc002bma.1_Missense_Mutation_p.L132F|AGBL1_uc002bmb.1_Missense_Mutation_p.L95F	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	401					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATCCAATAGTCTCAGGAGAGA	0.483			NA											16	80					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	15	102292797	102292797	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr15:102292797C>G	uc010usj.1	+	4	444	c.385C>G	c.(385-387)CCA>GCA	p.P129A	uc002bxo.2_RNA|uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						GAGCTGCTGTCCAACCTGCAC	0.597			NA											3	48					0	0	0.009096	0	0
CHTF18	63922	broad.mit.edu	37	16	840384	840384	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:840384C>G	uc002cke.3	+	6	800	c.737C>G	c.(736-738)TCA>TGA	p.S246*	RPUSD1_uc002cka.2_5'Flank|RPUSD1_uc002ckb.2_5'Flank|RPUSD1_uc002ckc.2_5'Flank|RPUSD1_uc002ckd.2_5'Flank|CHTF18_uc010uus.1_Missense_Mutation_p.F251L|CHTF18_uc010bre.1_RNA|CHTF18_uc002ckf.3_Nonsense_Mutation_p.S274*|CHTF18_uc010brf.2_5'UTR|CHTF18_uc002ckg.3_5'UTR	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	246					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				CAGAAGCTTTCAGACACCCTG	0.642			NA											3	25					0	0	0.004672	0	0
PKD1	5310	broad.mit.edu	37	16	2159023	2159023	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:2159023C>T	uc002cos.1	-	15	6354	c.6145G>A	c.(6145-6147)GAG>AAG	p.E2049K	PKD1_uc002cot.1_Missense_Mutation_p.E2049K	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2049	PKD 16.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GTGCGGTTCTCACTGCCCAGG	0.687			NA											6	40					0	0	0.001168	0	0
XYLT1	64131	broad.mit.edu	37	16	17235050	17235050	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:17235050T>C	uc002dfa.2	-	7	1632	c.1547A>G	c.(1546-1548)AAG>AGG	p.K516R		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	516	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CTGTTTCATCTTGGTCACCAG	0.502			NA											49	309					0	0	0.00361	0	0
UMOD	7369	broad.mit.edu	37	16	20355378	20355378	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:20355378G>A	uc002dgz.2	-	6	1428	c.1299C>T	c.(1297-1299)GTC>GTT	p.V433V	UMOD_uc002dha.2_Silent_p.V433V|UMOD_uc002dhb.2_Silent_p.V466V	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	433	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						TCTTCAGGCTGACTTTCATGT	0.532			NA											4	64					0	0	0.001168	0	0
SLC7A5P2	387254	broad.mit.edu	37	16	21531273	21531273	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:21531273G>A	uc002djd.2	-	1	493	c.414C>T	c.(412-414)CTC>CTT	p.L138L	uc002diq.3_Intron|LOC100271836_uc002dja.2_RNA|LOC100271836_uc002djb.2_RNA	NR_002594				RecName: Full=Putative L-type amino acid transporter 1-like protein MLAS; AltName: Full=hLAT1 3-transmembrane protein MLAS;          Short=hLAT1 3TM MLAS;												0						GCCGGATGATGAGCAGCTCGA	0.642			NA											5	68					0	0	0.004482	0	0
SRCAP	10847	broad.mit.edu	37	16	30749478	30749478	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:30749478C>A	uc002dze.1	+	34	8502	c.8117C>A	c.(8116-8118)TCA>TAA	p.S2706*	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Nonsense_Mutation_p.S2501*	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2706	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			ACCTCATCTTCAGCCACTTCC	0.602			NA											12	117					1.08611e-07	1.19776e-07	0.000978	1	0
ZNF319	57567	broad.mit.edu	37	16	58031380	58031380	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:58031380C>T	uc002emx.1	-	2	1413	c.790G>A	c.(790-792)GAG>AAG	p.E264K		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	264	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGTCTTCTCGCAGACTGCG	0.607			NA											19	64					0	0	0.007413	0	0
SLC9A5	6553	broad.mit.edu	37	16	67304692	67304692	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:67304692G>A	uc002esm.2	+	16	2333	c.2270G>A	c.(2269-2271)TGT>TAT	p.C757Y	SLC9A5_uc010cee.2_Missense_Mutation_p.C462Y|SLC9A5_uc010vji.1_Missense_Mutation_p.C261Y	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	757					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		TCCCCAACCTGTGCAGAAAAG	0.557			NA											13	15					0	0	0.001855	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683003	71683003	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:71683003G>A	uc002fax.2	-	18	3768	c.3762C>T	c.(3760-3762)CTC>CTT	p.L1254L	PHLPP2_uc002fav.2_Intron|PHLPP2_uc010cgf.2_Silent_p.L1187L	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	1254						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CCACTTCAATGAGGTTCAGGC	0.527			NA											50	73					0	0	0.00361	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683851	71683851	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:71683851G>A	uc002fax.2	-	18	2920	c.2914C>T	c.(2914-2916)CCG>TCG	p.P972S	PHLPP2_uc002fav.2_Intron|PHLPP2_uc010cgf.2_Missense_Mutation_p.P905S	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	972	PP2C-like.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						ATGGTCAGCGGAGTGGAAGAT	0.498			NA											42	61					0	0	0.006999	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465424	77465424	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr16:77465424C>A	uc002ffc.3	-	3	682	c.263G>T	c.(262-264)CGA>CTA	p.R88L	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	88					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTGCGCCGATCGCTTTTTCCT	0.483			NA											111	172					1.93806e-58	2.39467e-58	0.00361	1	0
OR1D2	4991	broad.mit.edu	37	17	2995820	2995820	+	Silent	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:2995820G>C	uc010vrb.1	-	1	471	c.471C>G	c.(469-471)CTC>CTG	p.L157L		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	157	Helical; Name=4; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GGGTGTGTATGAGGCCATAGA	0.507			NA											3	87					0	0	0.004672	0	0
NLRP1	22861	broad.mit.edu	37	17	5436173	5436173	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:5436173C>T	uc002gci.2	-	11	3820	c.3265G>A	c.(3265-3267)GAG>AAG	p.E1089K	NLRP1_uc002gcg.1_Missense_Mutation_p.E1093K|NLRP1_uc002gck.2_Missense_Mutation_p.E1089K|NLRP1_uc002gcj.2_Missense_Mutation_p.E1059K|NLRP1_uc002gcl.2_Missense_Mutation_p.E1059K|NLRP1_uc002gch.3_Missense_Mutation_p.E1089K|NLRP1_uc010clh.2_Missense_Mutation_p.E1089K	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1089					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				TCAACTACCTCAGTAGCCACA	0.612			NA											9	45					0	0	0.004482	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	A	rs11540652		TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:7577538C>A	uc002gim.2	-	7	937	c.743G>T	c.(742-744)CGG>CTG	p.R248L	TP53_uc002gig.1_Missense_Mutation_p.R248L|TP53_uc002gih.2_Missense_Mutation_p.R248L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116L|TP53_uc010cng.1_Missense_Mutation_p.R116L|TP53_uc002gii.1_Missense_Mutation_p.R116L|TP53_uc010cnh.1_Missense_Mutation_p.R248L|TP53_uc010cni.1_Missense_Mutation_p.R248L|TP53_uc002gij.2_Missense_Mutation_p.R248L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155L|TP53_uc002gio.2_Missense_Mutation_p.R116L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	Pancreas(47;798 1329 9957 10801)	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	77					1.12685e-05	1.20333e-05	0.004482	1	0
DNAH9	1770	broad.mit.edu	37	17	11532805	11532805	+	Silent	SNP	T	T	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:11532805T>C	uc002gne.2	+	7	1490	c.1422T>C	c.(1420-1422)GCT>GCC	p.A474A		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	474	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGGGAATGCTCTGAGTCAGC	0.498			NA											42	79					0	0	0.002852	0	0
PROCA1	147011	broad.mit.edu	37	17	27031336	27031336	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:27031336G>C	uc002hcb.3	-	4	554	c.351C>G	c.(349-351)TTC>TTG	p.F117L	PROCA1_uc010crv.2_Missense_Mutation_p.F43L|PROCA1_uc002hca.1_Missense_Mutation_p.F115L	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	143					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					AGCCATACCGGAATCGCTCCA	0.637			NA											55	142					0	0	0.00361	0	0
EFCAB5	374786	broad.mit.edu	37	17	28435021	28435021	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:28435021G>A	uc002het.2	+	23	4683	c.4491G>A	c.(4489-4491)GGG>GGA	p.G1497G	EFCAB5_uc010cse.2_Silent_p.G1252G|EFCAB5_uc010csf.2_Silent_p.G848G	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1497							calcium ion binding			ovary(1)|skin(1)	2						AAATGCCAGGGGAAGGTTTGC	0.343			NA											45	86					0	0	0.00361	0	0
JUP	3728	broad.mit.edu	37	17	39912446	39912446	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:39912446G>A	uc002hxq.2	-	13	2344	c.2067C>T	c.(2065-2067)ATC>ATT	p.I689I	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Silent_p.I689I|JUP_uc002hxs.2_Silent_p.I689I	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	689					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		AGGGCTCATTGATGGGAATCA	0.547	Colon(16;42 520 6044 17852 28530)		NA											4	48					0	0	0.009096	0	0
ABCA10	10349	broad.mit.edu	37	17	67148250	67148250	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:67148250G>A	uc010dfa.1	-	37	5210	c.4331C>T	c.(4330-4332)CCT>CTT	p.P1444L	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Missense_Mutation_p.P436L|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1444					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CACCTGGGTAGGTTCTTTCAT	0.383			NA											4	96					0	0	0.009096	0	0
MGAT5B	146664	broad.mit.edu	37	17	74901366	74901366	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:74901366C>T	uc002jti.2	+	6	942	c.839C>T	c.(838-840)GCC>GTC	p.A280V	MGAT5B_uc002jth.2_Missense_Mutation_p.A269V	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	269	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GCGCTGGCTGCCCAGCGCCTG	0.652			NA											25	53					0	0	0.00632	0	0
RPTOR	57521	broad.mit.edu	37	17	78599561	78599561	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr17:78599561C>A	uc002jyt.1	+	2	1038	c.233C>A	c.(232-234)ACC>AAC	p.T78N	RPTOR_uc002jys.2_Missense_Mutation_p.T78N|RPTOR_uc010wuf.1_5'UTR|RPTOR_uc010wug.1_Missense_Mutation_p.T78N	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	78					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						GTGGTGAAGACCACGCCCTGT	0.547			NA											26	81					3.73988e-18	4.43524e-18	0.00632	1	0
DLGAP1	9229	broad.mit.edu	37	18	3879390	3879390	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr18:3879390A>T	uc002kmf.2	-	1	746	c.679T>A	c.(679-681)TGC>AGC	p.C227S	DLGAP1_uc010wyz.1_Missense_Mutation_p.C227S|DLGAP1_uc002kmk.2_Missense_Mutation_p.C227S|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	227					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CGGTCGGGGCACCTGCCCATG	0.657			NA											28	112					0	0	0.00632	0	0
ASXL3	80816	broad.mit.edu	37	18	31323142	31323142	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr18:31323142C>T	uc010dmg.1	+	12	3385	c.3330C>T	c.(3328-3330)CTC>CTT	p.L1110L	ASXL3_uc002kxq.2_Silent_p.L817L	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGGCTAAGCTCTTTGCAAAGC	0.537			NA											15	43					0	0	0.00245	0	0
SETBP1	26040	broad.mit.edu	37	18	42643107	42643107	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr18:42643107G>A	uc010dni.2	+	6	4531	c.4235G>A	c.(4234-4236)CGG>CAG	p.R1412Q		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1412						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGCGAAGTGCGGAAGATGTGC	0.532			NA							Schinzel-Giedion_syndrome				7	28					0	0	0.001984	0	0
PHLPP1	23239	broad.mit.edu	37	18	60645807	60645807	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr18:60645807G>A	uc002lis.2	+	18	2939	c.2761G>A	c.(2761-2763)GAG>AAG	p.E921K		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1433					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CTGCTGCTGCGAGCTCAGCGC	0.622			NA											6	25					0	0	0.001984	0	0
FDX1L	112812	broad.mit.edu	37	19	10421236	10421236	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr19:10421236C>T	uc002mny.1	-	5	497	c.478G>A	c.(478-480)GAA>AAA	p.E160K	ZGLP1_uc002mnw.3_5'Flank|FDX1L_uc002mnx.1_RNA	NM_001031734	NP_001026904	Q6P4F2	ADXL_HUMAN	ferredoxin 1-like precursor	160	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(20;9.5e-10)|Epithelial(33;2.11e-06)|all cancers(31;5.06e-06)			TCCGCTCCTTCCAGCTCCGGT	0.592			NA											11	26					0	0	0.000978	0	0
TYK2	7297	broad.mit.edu	37	19	10476195	10476195	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr19:10476195C>T	uc002moc.3	-	7	1387	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	TYK2_uc010dxe.2_Missense_Mutation_p.E152K|TYK2_uc002mod.2_Missense_Mutation_p.E337K	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	337	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TTGCTCACCTCCTCCTTGTTC	0.637			NA											5	104					0	0	0.000602	0	0
KEAP1	9817	broad.mit.edu	37	19	10600365	10600365	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr19:10600365C>A	uc002moq.1	-	4	1646	c.1490G>T	c.(1489-1491)TGG>TTG	p.W497L	KEAP1_uc002mop.1_Missense_Mutation_p.W215L|KEAP1_uc002mor.1_Missense_Mutation_p.W497L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	497	Kelch 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GATCATTCGCCACTCGTTCCT	0.592			NA											44	26					3.21987e-24	3.87699e-24	0.00361	1	0
SLC7A10	56301	broad.mit.edu	37	19	33703454	33703454	+	Silent	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr19:33703454G>T	uc002num.2	-	4	747	c.600C>A	c.(598-600)CTC>CTA	p.L200L	SLC7A10_uc002nul.2_5'Flank|SLC7A10_uc010xrq.1_Silent_p.L173L	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	200					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					CGCCGATGATGAGGGACAAGG	0.652			NA											8	39					1.06961e-07	1.18511e-07	0.00308	1	0
ZFP36	7538	broad.mit.edu	37	19	39898488	39898488	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr19:39898488G>T	uc002olh.1	+	2	188	c.130G>T	c.(130-132)GAC>TAC	p.D44Y	ZFP36_uc010egn.1_5'UTR	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	44					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GAGCCCCTCCGACTCCAGCCC	0.726	NSCLC(67;1164 1324 12056 21056 30097)		NA											26	54					1.42536e-11	1.65706e-11	0.004656	1	0
ACPT	93650	broad.mit.edu	37	19	51298186	51298186	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr19:51298186C>G	uc002pta.1	+	10	1130	c.1130C>G	c.(1129-1131)TCC>TGC	p.S377C		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	377	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CATGGGGTCTCCTGCCATGGC	0.706			NA											8	115					0	0	0.006214	0	0
CRIM1	51232	broad.mit.edu	37	2	36764555	36764555	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:36764555A>G	uc002rpd.2	+	14	2528	c.2489A>G	c.(2488-2490)GAG>GGG	p.E830G		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	830	Extracellular (Potential).|VWFC 6.				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GCCGACGAGGAGCGGTGGGAC	0.582			NA											3	77					0	0	0.004672	0	0
RGPD4	285190	broad.mit.edu	37	2	108496510	108496510	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:108496510G>A	uc010ywk.1	+	21	5093	c.5011G>A	c.(5011-5013)GGC>AGC	p.G1671S	RGPD4_uc002tdu.2_Missense_Mutation_p.G858S|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1671					intracellular transport		binding			skin(2)	2						TCACTTAAACGGCCTGCTTCG	0.448			NA											26	187					0	0	0.007291	0	0
SULT1C3	442038	broad.mit.edu	37	2	108863691	108863691	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:108863691A>G	uc010ywo.1	+	1	41	c.41A>G	c.(40-42)AAG>AGG	p.K14R		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	14						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						ATGGAAAAAAAGCCAGAACTG	0.358			NA											3	77					0	0	0.004672	0	0
RGPD5	84220	broad.mit.edu	37	2	113190969	113190969	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:113190969G>A	uc002ths.1	-	1	139	c.62C>T	c.(61-63)TCG>TTG	p.S21L	RGPD8_uc010fkk.1_Intron|RGPD5_uc010yxm.1_Missense_Mutation_p.S21L	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	21					intracellular transport	cytoplasm	binding				0						CTGTCGAGGCGACGGGGTGAG	0.547			NA											12	46					0	0	0.00245	0	0
DPP10	57628	broad.mit.edu	37	2	116594317	116594317	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:116594317C>A	uc002tla.1	+	24	2634	c.2177C>A	c.(2176-2178)GCT>GAT	p.A726D	DPP10_uc002tlb.1_Missense_Mutation_p.A676D|DPP10_uc002tlc.1_Missense_Mutation_p.A722D|DPP10_uc002tle.2_Missense_Mutation_p.A730D|DPP10_uc002tlf.1_Missense_Mutation_p.A719D	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	726	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CATGGAACTGCTGACAGTAAG	0.358			NA											10	113					1.76689e-08	1.97624e-08	0.006214	1	0
UGGT1	56886	broad.mit.edu	37	2	128873862	128873862	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:128873862A>T	uc002tps.2	+	8	995	c.817A>T	c.(817-819)ATT>TTT	p.I273F	UGGT1_uc010fme.1_Missense_Mutation_p.I148F|UGGT1_uc002tpr.2_Missense_Mutation_p.I249F	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	273					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						CACCACAGTGATTGGTGAAAA	0.328			NA											4	70					0	0	0.009096	0	0
POTEF	728378	broad.mit.edu	37	2	130831864	130831864	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:130831864C>A	uc010fmh.2	-	17	3581	c.3181G>T	c.(3181-3183)GAG>TAG	p.E1061*		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	1061	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						TCATCATACTCCTGCTTGCTG	0.537			NA											96	70					6.29576e-42	7.73854e-42	0.00361	1	0
TUBA3E	112714	broad.mit.edu	37	2	130951410	130951410	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:130951410G>C	uc002tqv.2	-	4	1106	c.1005C>G	c.(1003-1005)ATC>ATG	p.I335M		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	335					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					GCTTGGTCTTGATGGTGGCGA	0.547			NA											22	127					0	0	0.001882	0	0
RIF1	55183	broad.mit.edu	37	2	152331516	152331516	+	Silent	SNP	T	T	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:152331516T>C	uc002txm.2	+	36	7480	c.7350T>C	c.(7348-7350)TGT>TGC	p.C2450C	RIF1_uc002txl.2_Silent_p.C2424C|RIF1_uc002txn.2_Silent_p.C2424C|RIF1_uc002txo.2_Silent_p.C2424C|RIF1_uc002txp.2_RNA|uc010fnw.1_5'Flank	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2450	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AACTAAGTTGTATGGCAAACT	0.343			NA											19	22					0	0	0.008871	0	0
BAZ2B	29994	broad.mit.edu	37	2	160204009	160204009	+	Silent	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:160204009A>G	uc002uao.2	-	31	5794	c.5442T>C	c.(5440-5442)AGT>AGC	p.S1814S	BAZ2B_uc002uap.2_Silent_p.S1778S	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1814					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TCACTTGCAAACTTGCTGATG	0.289			NA											13	63					0	0	0.001855	0	0
KIAA1486	57624	broad.mit.edu	37	2	226273717	226273717	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:226273717G>C	uc002voe.2	+	2	296	c.121G>C	c.(121-123)GAT>CAT	p.D41H	KIAA1486_uc010fxa.1_Missense_Mutation_p.D36H	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	41										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GAATGCGTCAGATATTGCTCG	0.418			NA											18	82					0	0	0.006122	0	0
KIAA1486	57624	broad.mit.edu	37	2	226273727	226273727	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:226273727G>A	uc002voe.2	+	2	306	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	KIAA1486_uc010fxa.1_Missense_Mutation_p.R39Q	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	44										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GATATTGCTCGAGAGAATGAT	0.408			NA											16	70					0	0	0.004007	0	0
PAX1	5075	broad.mit.edu	37	20	21687351	21687351	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr20:21687351G>T	uc002wsj.2	+	2	616	c.562G>T	c.(562-564)GAC>TAC	p.D188Y	PAX1_uc010zsl.1_Missense_Mutation_p.D188Y|PAX1_uc010zsm.1_Missense_Mutation_p.D164Y	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	188	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CAAGCAAGGAGACCCTGGCAT	0.637			NA											16	79					0.000308642	0.000323731	0.003163	1	0
RALGAPB	57148	broad.mit.edu	37	20	37195789	37195789	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr20:37195789G>A	uc002xiw.2	+	26	4125	c.3868G>A	c.(3868-3870)GAT>AAT	p.D1290N	RALGAPB_uc002xix.2_Missense_Mutation_p.D1287N|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.D1069N	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1290	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TTCAAATATGGATCTTATGCC	0.378			NA											32	50					0	0	0.002445	0	0
KCNB1	3745	broad.mit.edu	37	20	47990416	47990416	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr20:47990416C>G	uc002xur.1	-	2	1845	c.1681G>C	c.(1681-1683)GAA>CAA	p.E561Q	KCNB1_uc002xus.1_Missense_Mutation_p.E561Q	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	561	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTCTCCATTTCAAGTTCTTCC	0.493			NA											9	125					0	0	0.006214	0	0
MOCS3	27304	broad.mit.edu	37	20	49576335	49576335	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr20:49576335C>T	uc002xvy.1	+	1	973	c.956C>T	c.(955-957)TCA>TTA	p.S319L	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	319					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						TGTGGCTCCTCAGCCACTGAT	0.587			NA											18	102					0	0	0.007413	0	0
CASS4	57091	broad.mit.edu	37	20	55033749	55033749	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr20:55033749G>A	uc002xxp.2	+	7	2532	c.2307G>A	c.(2305-2307)GCG>GCA	p.A769A	CASS4_uc002xxr.2_Silent_p.A769A|CASS4_uc010zze.1_Silent_p.A715A|CASS4_uc010gio.2_Silent_p.A332A	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	769					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						ACCTCCAGGCGGAGGCTGAGA	0.627			NA											15	16					0	0	0.00499	0	0
ZBP1	81030	broad.mit.edu	37	20	56186808	56186808	+	Silent	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr20:56186808G>T	uc002xyo.2	-	6	1130	c.849C>A	c.(847-849)GCC>GCA	p.A283A	ZBP1_uc010gjm.2_Silent_p.A282A|ZBP1_uc002xyp.2_Silent_p.A208A	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	283						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GGGGGATGTGGGCAGGGCCCT	0.642			NA											17	15					5.03518e-11	5.7966e-11	0.007413	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19770546	19770546	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr21:19770546G>A	uc002ykw.2	-	2	277	c.246C>T	c.(244-246)TTC>TTT	p.F82F		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	82	Extracellular (Potential).|SEA.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CAAGAACTTTGAAATCCACTG	0.383			NA											23	20					0	0	0.002299	0	0
SYNJ1	8867	broad.mit.edu	37	21	34072413	34072413	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr21:34072413C>T	uc002yqh.2	-	4	331	c.331G>A	c.(331-333)GAT>AAT	p.D111N	SYNJ1_uc011ads.1_Missense_Mutation_p.D72N|SYNJ1_uc002yqf.2_Missense_Mutation_p.D72N|SYNJ1_uc002yqg.2_Missense_Mutation_p.D72N|SYNJ1_uc002yqi.2_Missense_Mutation_p.D111N	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	72							inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						AACATAGTATCACCTGCAAAA	0.343			NA											13	41					0	0	0.001855	0	0
SON	6651	broad.mit.edu	37	21	34922804	34922804	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr21:34922804C>T	uc002yse.1	+	3	1316	c.1267C>T	c.(1267-1269)CCA>TCA	p.P423S	SON_uc002ysb.1_Missense_Mutation_p.P423S|SON_uc002ysc.2_Missense_Mutation_p.P423S|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	423					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						CCTTTCTACCCCAGTGCCTGA	0.652			NA											16	72					0	0	0.003163	0	0
EWSR1	2130	broad.mit.edu	37	22	29695251	29695251	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr22:29695251G>C	uc003aet.2	+	15	1936	c.1608G>C	c.(1606-1608)TGG>TGC	p.W536C	EWSR1_uc003aev.2_Missense_Mutation_p.W541C|EWSR1_uc003aew.2_Missense_Mutation_p.W480C|EWSR1_uc003aex.2_Missense_Mutation_p.W535C|EWSR1_uc003aey.2_Missense_Mutation_p.W331C|EWSR1_uc003aez.2_Missense_Mutation_p.W197C	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	536	RanBP2-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						ACTTCGCCTGGAGAACAGAGT	0.517			NA	T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								19	126					0	0	0.001523	0	0
APOL5	80831	broad.mit.edu	37	22	36123141	36123141	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr22:36123141G>A	uc003aof.2	+	3	1026	c.1026G>A	c.(1024-1026)CGG>CGA	p.R342R		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	342					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						AGCTGGACCGGCTCACCCAGC	0.627			NA											27	33					0	0	0.003954	0	0
NPTXR	23467	broad.mit.edu	37	22	39219239	39219239	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr22:39219239T>A	uc003awk.2	-	4	1281	c.1127A>T	c.(1126-1128)GAC>GTC	p.D376V		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	376	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CCAGCCATTGTCCTTCAGGCT	0.657	Pancreas(139;2521 3281 36965)		NA											9	42					0	0	0.004482	0	0
ZNF620	253639	broad.mit.edu	37	3	40552972	40552972	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:40552972C>T	uc003ckk.2	+	3	185	c.36C>T	c.(34-36)ACC>ACT	p.T12T	ZNF620_uc003ckl.2_Intron	NM_175888	NP_787084	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	12	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		AACCAGTGACCTTTGAGGATG	0.512			NA											5	152					0	0	0.000602	0	0
TMF1	7110	broad.mit.edu	37	3	69097684	69097684	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:69097684C>G	uc003dnn.2	-	2	419	c.172G>C	c.(172-174)GAT>CAT	p.D58H	TMF1_uc011bfx.1_Missense_Mutation_p.D58H	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	58					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GTTGAAGTATCCCATCCTCCA	0.373			NA											4	94					0	0	0.009096	0	0
DPPA2	151871	broad.mit.edu	37	3	109031471	109031471	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:109031471G>A	uc003dxo.2	-	3	349	c.102C>T	c.(100-102)GAC>GAT	p.D34D		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	34						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CCATATTTGCGTCATCTTTAA	0.413			NA											5	89					0	0	0.000602	0	0
COPG	22820	broad.mit.edu	37	3	128979633	128979633	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:128979633A>G	uc003els.2	+	12	1211	c.1111A>G	c.(1111-1113)ATC>GTC	p.I371V	COPG_uc010htb.2_Missense_Mutation_p.I277V	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	371	HEAT 4.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						CATGTCAGAAATCTCGGATGA	0.602			NA											5	55					0	0	0.000602	0	0
DVL3	1857	broad.mit.edu	37	3	183885740	183885741	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:183885740_183885741GG>TT	uc003fms.2	+	13	1525_1526	c.1385_1386GG>TT	c.(1384-1386)AGG>ATT	p.R462I	DVL3_uc011bqw.1_Missense_Mutation_p.R445I|DVL3_uc003fmt.2_Missense_Mutation_p.R133I|DVL3_uc003fmu.2_Missense_Mutation_p.R294I	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	462	DEP.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			ACGGACCGGAGGGAGGCCCGCA	0.574			NA											21	57					0	0	0.004672	0	0
VPS8	23355	broad.mit.edu	37	3	184675167	184675167	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:184675167G>A	uc003fpb.1	+	36	3206	c.3035G>A	c.(3034-3036)GGT>GAT	p.G1012D	VPS8_uc010hyd.1_Missense_Mutation_p.G922D|VPS8_uc010hye.1_Missense_Mutation_p.G441D	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1014							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TTTAGGGAAGGTATTCATGTA	0.318			NA											6	17					0	0	0.00308	0	0
ATP13A3	79572	broad.mit.edu	37	3	194180676	194180676	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr3:194180676C>T	uc003fty.3	-	4	652	c.250G>A	c.(250-252)GCA>ACA	p.A84T		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	84					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CGAATTTTTGCACAAAACCAC	0.323			NA											14	25					0	0	0.003163	0	0
WDR1	9948	broad.mit.edu	37	4	10084647	10084647	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:10084647T>A	uc003gmf.2	-	10	1478	c.1195A>T	c.(1195-1197)AGC>TGC	p.S399C	WDR1_uc003gmg.2_Missense_Mutation_p.S259C|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	399	WD 7.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TGCTCTCACCTGTAGTCCCGC	0.627			NA											11	33					0	0	0.000978	0	0
HS3ST1	9957	broad.mit.edu	37	4	11400725	11400725	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:11400725C>G	uc003gmq.2	-	2	1228	c.905G>C	c.(904-906)AGA>ACA	p.R302T		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	302						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						GTCAAATGTTCTGCCAACAAG	0.418			NA											18	72					0	0	0.007413	0	0
CWH43	80157	broad.mit.edu	37	4	49046815	49046815	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:49046815A>G	uc003gyv.2	+	14	1998	c.1816A>G	c.(1816-1818)ACT>GCT	p.T606A	CWH43_uc011bzl.1_Missense_Mutation_p.T579A	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	606					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TATCGACAGCACTGATCATGA	0.358			NA											9	59					0	0	0.006214	0	0
KIAA1211	57482	broad.mit.edu	37	4	57189656	57189656	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:57189656C>T	uc003hbk.2	+	9	3692	c.3301C>T	c.(3301-3303)CGG>TGG	p.R1101W	KIAA1211_uc010iha.2_Missense_Mutation_p.R1094W	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1101										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AAAGGGGTTTCGGGAGCAGCA	0.522			NA											18	25					0	0	0.006122	0	0
HSD17B11	51170	broad.mit.edu	37	4	88312133	88312133	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:88312133C>T	uc003hqp.2	-	1	323	c.90G>A	c.(88-90)AGG>AGA	p.R30R		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	30					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		CTGATTTTCTCCTCTTAGGAA	0.463			NA											3	43					0	0	0.004672	0	0
MTTP	4547	broad.mit.edu	37	4	100518350	100518350	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:100518350C>A	uc003hvc.3	+	9	1292	c.1036C>A	c.(1036-1038)CAA>AAA	p.Q346K	MTTP_uc011cej.1_Missense_Mutation_p.Q373K	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	346	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	AGAGATCCTTCAAATACTAAA	0.428			NA											8	68					0.000274275	0.000288968	0.004482	1	0
ALPK1	80216	broad.mit.edu	37	4	113352234	113352234	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:113352234C>T	uc003iap.3	+	11	1810	c.1531C>T	c.(1531-1533)CAT>TAT	p.H511Y	ALPK1_uc003ian.3_Missense_Mutation_p.H511Y|ALPK1_uc011cfx.1_Missense_Mutation_p.H433Y|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.H339Y	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	511							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AGAAAAGCCACATTGTCAAAG	0.403			NA											19	23					0	0	0.001523	0	0
SYNPO2	171024	broad.mit.edu	37	4	119948362	119948362	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:119948362G>T	uc003icm.3	+	3	1034	c.838G>T	c.(838-840)GGA>TGA	p.G280*	SYNPO2_uc010ina.2_Nonsense_Mutation_p.G280*|SYNPO2_uc010inb.2_Nonsense_Mutation_p.G280*|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Nonsense_Mutation_p.G208*	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	280						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AGGAGATGCGGGACTGCCCCG	0.537			NA											22	26					5.26018e-13	6.17613e-13	0.001882	1	0
MYOZ2	51778	broad.mit.edu	37	4	120085430	120085430	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:120085430C>T	uc003icp.3	+	5	654	c.441C>T	c.(439-441)TAC>TAT	p.Y147Y		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	147							protein phosphatase 2B binding				0						TCCCTAAGTACTATCAATCTC	0.403			NA											8	33					0	0	0.00308	0	0
MLF1IP	79682	broad.mit.edu	37	4	185618908	185618908	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr4:185618908C>G	uc003iwq.2	-	12	1106	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q	MLF1IP_uc003iwp.2_RNA|MLF1IP_uc003iwr.1_3'UTR	NM_024629	NP_078905	Q71F23	CENPU_HUMAN	MLF1 interacting protein	346	Potential.				CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm					0		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		GACTTTCTCTCTTTAAGTTCA	0.323			NA											3	24					0	0	0.004672	0	0
CEP72	55722	broad.mit.edu	37	5	634005	634005	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr5:634005C>T	uc003jbf.2	+	5	706	c.634C>T	c.(634-636)CCC>TCC	p.P212S	CEP72_uc011clz.1_Intron	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	212					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CGGCAGGCCTCCCGGGAGCAC	0.657			NA											6	184					0	0	0.001168	0	0
KIAA0947	23379	broad.mit.edu	37	5	5464745	5464745	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr5:5464745C>T	uc003jdm.3	+	13	5520	c.5298C>T	c.(5296-5298)CTC>CTT	p.L1766L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1766										ovary(1)|central_nervous_system(1)	2						CCCGGACCCTCAACATCCTCA	0.517			NA											5	32					0	0	0.000602	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502747	140502747	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr5:140502747G>A	uc003lip.1	+	1	1167	c.1167G>A	c.(1165-1167)CCG>CCA	p.P389P		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	389	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAATCTACCGTTTATTCTAA	0.433			NA											69	42					0	0	0.00361	0	0
NUDCD2	134492	broad.mit.edu	37	5	162883952	162883952	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr5:162883952C>G	uc003lze.2	-	3	460	c.373G>C	c.(373-375)GAG>CAG	p.E125Q		NM_145266	NP_660309	Q8WVJ2	NUDC2_HUMAN	NudC domain containing 2	125						intracellular					0	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)		TGGAATCTCTCTAATGTAAGC	0.308			NA											6	37					0	0	0.001984	0	0
BTNL8	79908	broad.mit.edu	37	5	180338435	180338435	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr5:180338435C>A	uc003mmp.2	+	3	728	c.494C>A	c.(493-495)GCG>GAG	p.A165E	BTNL8_uc003mmq.2_Missense_Mutation_p.A165E|BTNL8_uc011dhg.1_Missense_Mutation_p.A40E|BTNL8_uc010jll.2_Missense_Mutation_p.A165E|BTNL8_uc010jlm.2_Missense_Mutation_p.A49E|BTNL8_uc011dhh.1_5'UTR	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	165	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGCCCACAGCGAAGTGGAAA	0.537			NA											8	203					0.000157383	0.000166558	0.00308	1	0
GMDS	2762	broad.mit.edu	37	6	1742745	1742745	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:1742745C>T	uc003mtq.2	-	8	1037	c.847G>A	c.(847-849)GAA>AAA	p.E283K		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	283					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TCGACAAATTCCCGGACACTA	0.458			NA											18	81					0	0	0.008871	0	0
TRIM27	5987	broad.mit.edu	37	6	28891242	28891242	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:28891242G>C	uc003nlr.2	-	1	527	c.168C>G	c.(166-168)TGC>TGG	p.C56W	TRIM27_uc003nls.2_Missense_Mutation_p.C56W|TRIM27_uc003nlt.1_Missense_Mutation_p.C56W	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	56	RING-type.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						AGGTCTCCCGGCACTGCGGGC	0.682			NA	T	RET	papillary thyroid								6	38					0	0	0.001984	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32920762	32920762	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:32920762G>A	uc003ocm.2	-	1	138	c.52C>T	c.(52-54)CTG>TTG	p.L18L	HLA-DMA_uc011dqm.1_Silent_p.L18L	NM_006120	NP_006111	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM	18						integral to membrane|MHC class II protein complex					0						AGCAGCCACAGAAGTGGTAAC	0.537			NA											7	282					0	0	0.00308	0	0
CUL9	23113	broad.mit.edu	37	6	43152373	43152373	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:43152373G>A	uc003ouk.2	+	2	400	c.325G>A	c.(325-327)GAA>AAA	p.E109K	CUL9_uc003ouj.1_Missense_Mutation_p.E109K|CUL9_uc003oul.2_Missense_Mutation_p.E109K|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	109					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						AGGCCTGGATGAAGTGGCAAT	0.612			NA											15	245					0	0	0.004007	0	0
ZNF318	24149	broad.mit.edu	37	6	43308072	43308072	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:43308072C>G	uc003oux.2	-	10	3742	c.3664G>C	c.(3664-3666)GAA>CAA	p.E1222Q	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1222	Lys-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TCCTTTACTTCTTTCACAGCC	0.448			NA											37	239					0	0	0.004878	0	0
FAM135A	57579	broad.mit.edu	37	6	71235143	71235143	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:71235143G>A	uc003pfj.2	+	13	2489	c.2356G>A	c.(2356-2358)GAT>AAT	p.D786N	FAM135A_uc003pfi.2_Missense_Mutation_p.D590N|FAM135A_uc003pfh.2_Missense_Mutation_p.D573N|FAM135A_uc003pfl.2_Missense_Mutation_p.D453N|FAM135A_uc003pfn.2_Intron|FAM135A_uc003pfo.1_Missense_Mutation_p.D157N|FAM135A_uc010kan.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	786										central_nervous_system(1)	1						TCCAAACACTGATTTAGTCTT	0.353			NA											12	49					0	0	0.003163	0	0
RARS2	57038	broad.mit.edu	37	6	88240532	88240532	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:88240532C>G	uc003pme.2	-	9	801	c.741G>C	c.(739-741)TTG>TTC	p.L247F	RARS2_uc003pmb.2_Missense_Mutation_p.L72F|RARS2_uc003pmc.2_Missense_Mutation_p.L72F|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	247					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		CTTCAATGCTCAAGTCCCGAA	0.463			NA											13	52					0	0	0.001368	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138200479	138200479	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:138200479G>A	uc003qhr.2	+	7	1963	c.1897G>A	c.(1897-1899)GAA>AAA	p.E633K	TNFAIP3_uc003qhs.2_Missense_Mutation_p.E633K	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	633	Interaction with NAF1 (By similarity).|A20-type 4.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)|p.?(1)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CGAGTACAGAGAAAACAAACG	0.493	GBM(130;153 1739 22295 28918 47987)		NA	D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								7	60					0	0	0.001984	0	0
REPS1	85021	broad.mit.edu	37	6	139251135	139251135	+	Silent	SNP	A	A	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr6:139251135A>C	uc003qii.2	-	9	1815	c.1236T>G	c.(1234-1236)CCT>CCG	p.P412P	REPS1_uc003qig.3_Silent_p.P412P|REPS1_uc011edr.1_Silent_p.P412P|REPS1_uc003qij.2_Silent_p.P412P|REPS1_uc003qik.2_Silent_p.P45P	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	412						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		GATTCAGCTCAGGCCATGTCT	0.448			NA											4	60					0	0	0.009096	0	0
C7orf26	79034	broad.mit.edu	37	7	6641768	6641768	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:6641768A>G	uc003sqo.1	+	5	1145	c.1145A>G	c.(1144-1146)AAT>AGT	p.N382S	C7orf26_uc003sqp.1_Missense_Mutation_p.N285S|C7orf26_uc003sqq.1_Missense_Mutation_p.N183S	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	382										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		CTGCCCCATAATAAGTAAGTA	0.512			NA									OREG0017863	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	112					0	0	0.009096	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26233309	26233309	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:26233309T>A	uc003sxr.3	-	9	979	c.763A>T	c.(763-765)AAT>TAT	p.N255Y	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.N243Y	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	255	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCTCCAAAATTGCCACCTATT	0.443			NA	T	ETV1	prostate								27	41					0	0	0.005443	0	0
BMPER	168667	broad.mit.edu	37	7	34182860	34182860	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:34182860G>T	uc011kap.1	+	14	1878	c.1764G>T	c.(1762-1764)ATG>ATT	p.M588I		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	588					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGACAGACATGTGTGAATGTC	0.428			NA											24	87					1.85244e-09	2.10181e-09	0.00333	1	0
C7orf36	57002	broad.mit.edu	37	7	39610105	39610105	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:39610105G>A	uc003thc.3	+	2	139	c.130G>A	c.(130-132)GAA>AAA	p.E44K		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	44											0						TTATTTTTAGGAAGGTTATAG	0.358			NA											6	59					0	0	0.001168	0	0
CCL24	6369	broad.mit.edu	37	7	75441236	75441236	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:75441236C>A	uc011kga.1	-	3	238	c.238G>T	c.(238-240)GAG>TAG	p.E80*		NM_002991	NP_002982	O00175	CCL24_HUMAN	small inducible cytokine A24 precursor	80					cell-cell signaling|chemotaxis|immune response|inflammatory response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|signal transduction	extracellular space	chemokine activity				0						TGGACCCACTCCTGCTTGGGG	0.602			NA											34	45					1.30293e-26	1.59323e-26	0.003271	1	0
CROT	54677	broad.mit.edu	37	7	86991112	86991112	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:86991112C>G	uc003uit.2	+	6	736	c.491C>G	c.(490-492)TCT>TGT	p.S164C	CROT_uc003uiu.2_Missense_Mutation_p.S192C	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	164					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	ATGCTATTTTCTACCTGCAAG	0.323			NA											5	90					0	0	0.000602	0	0
MUC17	140453	broad.mit.edu	37	7	100679181	100679181	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:100679181C>T	uc003uxp.1	+	3	4537	c.4484C>T	c.(4483-4485)TCT>TTT	p.S1495F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1495	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|23.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGTTCATCTCCTACACCT	0.502			NA											58	244					0	0	0.00361	0	0
RELN	5649	broad.mit.edu	37	7	103137192	103137192	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:103137192C>T	uc003vca.2	-	56	9134	c.8974G>A	c.(8974-8976)GAG>AAG	p.E2992K	RELN_uc010liz.2_Missense_Mutation_p.E2992K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2992					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAATCCATCTCATGGAGCAAA	0.408	NSCLC(146;835 1944 15585 22231 52158)		NA											8	49					0	0	0.008291	0	0
MET	4233	broad.mit.edu	37	7	116435970	116435970	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:116435970C>A	uc003vij.2	+	21	4152	c.3965C>A	c.(3964-3966)CCT>CAT	p.P1322H	MET_uc010lkh.2_Missense_Mutation_p.P1340H|MET_uc011knj.1_Missense_Mutation_p.P892H	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1322	Protein kinase.|Interaction with MUC20.|Interaction with RANBP9.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGCTGGCACCCTAAAGCCGAA	0.438			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				4	75					0.00909568	0.0094563	0.009096	1	0
RNF133	168433	broad.mit.edu	37	7	122338615	122338615	+	Missense_Mutation	SNP	T	T	C	rs140861967		TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:122338615T>C	uc003vkj.1	-	1	594	c.358A>G	c.(358-360)ACT>GCT	p.T120A	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	120	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						CCCTTCTCAGTTGCCACTTTA	0.458	Colon(198;1778 2057 7449 19869 45985)		NA											8	155					0	0	0.00308	0	0
FLNC	2318	broad.mit.edu	37	7	128493015	128493015	+	Silent	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:128493015C>G	uc003vnz.3	+	37	6347	c.6138C>G	c.(6136-6138)GTC>GTG	p.V2046V	FLNC_uc003voa.3_Silent_p.V2013V	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2046	Filamin 19.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGGTGCGGGTCTGGGGCAAGG	0.617			NA											14	61					0	0	0.004007	0	0
EXOC4	60412	broad.mit.edu	37	7	133164812	133164812	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:133164812C>T	uc003vrk.2	+	9	1372	c.1337C>T	c.(1336-1338)TCG>TTG	p.S446L	EXOC4_uc011kpo.1_Missense_Mutation_p.S345L|EXOC4_uc003vri.2_Missense_Mutation_p.S446L|EXOC4_uc003vrj.2_Missense_Mutation_p.S446L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	446					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGGTTCGAATCGTCCTCCCAT	0.483			NA											22	67					0	0	0.00278	0	0
KEL	3792	broad.mit.edu	37	7	142641793	142641793	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:142641793G>A	uc003wcb.2	-	12	1560	c.1350C>T	c.(1348-1350)CTC>CTT	p.L450L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	450	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GGCGAGTGATGAGGGCATCCC	0.612			NA											7	25					0	0	0.004482	0	0
OR6B1	135946	broad.mit.edu	37	7	143701741	143701741	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:143701741T>C	uc003wdt.1	+	1	652	c.652T>C	c.(652-654)TAC>CAC	p.Y218H		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TGTCCTGTCCTACGGATGCAT	0.463			NA											90	108					0	0	0.00361	0	0
SLC4A2	6522	broad.mit.edu	37	7	150767303	150767303	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr7:150767303G>T	uc003wit.3	+	10	1575	c.1319G>T	c.(1318-1320)CGC>CTC	p.R440L	SLC4A2_uc011kve.1_Missense_Mutation_p.R431L|SLC4A2_uc003wiu.3_Missense_Mutation_p.R426L|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	440	Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTTCCCCCGCAACATCTCA	0.632			NA											11	108					0.00010058	0.000106923	0.001368	1	0
DPYSL2	1808	broad.mit.edu	37	8	26492307	26492307	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:26492307A>T	uc003xfb.1	+	8	1052	c.702A>T	c.(700-702)GAA>GAT	p.E234D	DPYSL2_uc003xfa.2_Missense_Mutation_p.E339D|DPYSL2_uc011lag.1_Missense_Mutation_p.E234D|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.E198D	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	234					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		TCGAGGCCGAAGCCGTGAATC	0.572			NA											18	106					0	0	0.001882	0	0
ANK1	286	broad.mit.edu	37	8	41581127	41581127	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:41581127C>T	uc003xok.2	-	8	820	c.736G>A	c.(736-738)GCC>ACC	p.A246T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.A246T|ANK1_uc003xoj.2_Missense_Mutation_p.A246T|ANK1_uc003xol.2_Missense_Mutation_p.A246T|ANK1_uc003xom.2_Missense_Mutation_p.A279T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	246	ANK 7.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTGCGGGAGGCGATGTGCAGT	0.632			NA											13	72					0	0	0.00245	0	0
MYST3	7994	broad.mit.edu	37	8	41791420	41791420	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:41791420C>A	uc010lxb.2	-	18	4862	c.4318G>T	c.(4318-4320)GAG>TAG	p.E1440*	MYST3_uc010lxc.2_Nonsense_Mutation_p.E1440*|MYST3_uc003xon.3_Nonsense_Mutation_p.E1440*	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1440					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TAGGCGCCCTCATGCTCACTG	0.507			NA											72	111					5.72124e-26	6.95986e-26	0.00361	1	0
PDE7A	5150	broad.mit.edu	37	8	66753652	66753652	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:66753652G>C	uc003xvq.2	-	1	104	c.92C>G	c.(91-93)TCC>TGC	p.S31C	PDE7A_uc003xvr.2_Missense_Mutation_p.S31C	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	31	Poly-Ser.					cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	AGCGGAGCTGGAGCTGAAGCT	0.632			NA											7	35					0	0	0.001984	0	0
TPD52	7163	broad.mit.edu	37	8	80976821	80976821	+	Silent	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:80976821C>T	uc003ybr.1	-	2	469	c.147G>A	c.(145-147)CTG>CTA	p.L49L	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Silent_p.L9L|TPD52_uc003ybt.1_Silent_p.L9L|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	49					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			GGTCTGTTCTCAGCAGACCTG	0.463			NA											17	90					0	0	0.007413	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885129	88885129	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:88885129G>A	uc003ydz.2	-	1	1168	c.1071C>T	c.(1069-1071)CCC>CCT	p.P357P		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	357										ovary(1)	1						TCTCCGAGGCGGGGTATGGGG	0.617			NA											36	50					0	0	0.002836	0	0
NBN	4683	broad.mit.edu	37	8	90983437	90983437	+	Silent	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:90983437G>A	uc003yej.1	-	6	776	c.666C>T	c.(664-666)TTC>TTT	p.F222F	NBN_uc003yei.1_Silent_p.F140F|NBN_uc011lgb.1_Silent_p.F222F	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	222					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTTTCCCTTTGAAGATTTGTT	0.289			NA						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				5	25					0	0	0.000602	0	0
WISP1	8840	broad.mit.edu	37	8	134233066	134233066	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr8:134233066C>A	uc003yub.2	+	3	668	c.592C>A	c.(592-594)CGT>AGT	p.R198S	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	198					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GACCGCACCCCGTGACACAGG	0.642			NA											17	40					1.99824e-07	2.19341e-07	0.00499	1	0
SH3GL2	6456	broad.mit.edu	37	9	17789495	17789495	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr9:17789495G>A	uc003zna.2	+	6	859	c.571G>A	c.(571-573)GAT>AAT	p.D191N	SH3GL2_uc011lmx.1_Missense_Mutation_p.D156N|SH3GL2_uc011lmy.1_Missense_Mutation_p.D144N	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	191	BAR.|Potential.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AGAGAAATTTGATGAGTCTAA	0.408			NA											14	18					0	0	0.00245	0	0
TAF1L	138474	broad.mit.edu	37	9	32634735	32634735	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr9:32634735C>G	uc003zrg.1	-	1	933	c.843G>C	c.(841-843)AAG>AAC	p.K281N	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	281					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCTTCTTCCTCTTTCTCCGAG	0.463			NA											4	95					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	9	90748512	90748512	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr9:90748512T>A	uc011lti.1	-	2	291	c.262A>T	c.(262-264)AGA>TGA	p.R88*						SubName: Full=cDNA FLJ59639;												NA						GCCTTACCTCTCAGACTGTGG	0.547			NA											34	38					0	0	0.00361	0	0
TLR4	7099	broad.mit.edu	37	9	120476775	120476775	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr9:120476775G>A	uc004bjz.2	+	3	2660	c.2369G>A	c.(2368-2370)AGC>AAC	p.S790N	TLR4_uc004bka.2_Missense_Mutation_p.S750N|TLR4_uc004bkb.2_Missense_Mutation_p.S590N	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	790	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CGCCTTCTCAGCAGGAACACT	0.547			NA											5	86					0	0	0.000602	0	0
KCNT1	57582	broad.mit.edu	37	9	138683691	138683691	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr9:138683691C>A	uc011mdq.1	+	30	3625	c.3551C>A	c.(3550-3552)CCT>CAT	p.P1184H	KCNT1_uc011mdr.1_Missense_Mutation_p.P1032H|KCNT1_uc010nbf.2_Missense_Mutation_p.P1160H	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	1184						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CTCATCAACCCTCCGCCCGAC	0.642			NA											47	32					1.63038e-21	1.95314e-21	0.00361	1	0
FAM47C	442444	broad.mit.edu	37	X	37028517	37028517	+	Silent	SNP	C	C	G			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chrX:37028517C>G	uc004ddl.1	+	1	2048	c.2034C>G	c.(2032-2034)CTC>CTG	p.L678L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	678										ovary(3)	3						TGTCCCATCTCTGCCCGGAGC	0.642			NA											8	44					0	0	0.004482	0	0
DYNLT3	6990	broad.mit.edu	37	X	37700311	37700311	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chrX:37700311T>A	uc004dds.2	-	4	370	c.244A>T	c.(244-246)AGC>TGC	p.S82C		NM_006520	NP_006511	P51808	DYLT3_HUMAN	dynein, light chain, Tctex-type 3	82					cell division|mitosis|regulation of mitotic cell cycle|transport	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|nucleus|plasma membrane	motor activity				0						AAACAGGAGCTGGCTGTGTGA	0.423			NA											9	28					0	0	0.000978	0	0
TRO	7216	broad.mit.edu	37	X	54955213	54955213	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chrX:54955213G>A	uc004dtq.2	+	12	2163	c.2056G>A	c.(2056-2058)GAC>AAC	p.D686N	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.D217N|TRO_uc004dtw.2_Missense_Mutation_p.D289N|TRO_uc004dtx.2_Missense_Mutation_p.D69N	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	686					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CATGGATATCGACTGCCTAAC	0.274			NA											14	9					0	0	0.001855	0	0
Unknown	0	broad.mit.edu	37	X	155254706	155254706	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chrX:155254706C>T	uc004fnx.3	+	8	1056	c.602C>T	c.(601-603)ACG>ATG	p.T201M		NM_182905	NP_878908			WAS protein family homolog 1												NA						GTGAGAGCCACGAGCCAAGGT	0.637			NA											4	7					0	0	0.000602	0	0
TECTA	7007	broad.mit.edu	37	11	121000388	121000388	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr11:121000388delG	uc010rzo.1	+	9	2409	c.2409delG	c.(2407-2409)TCGfs	p.S803fs		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	803	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCCATCCTTCGGGGAAGCTGG	0.438			NA											50	124	---	---	---	---	NA	NA	NA	NA	NA
UBC	7316	broad.mit.edu	37	12	125397413	125397414	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr12:125397413_125397414insT	uc001ugs.3	-	2	1352_1353	c.904_905insA	c.(904-906)AGAfs	p.R302fs	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Frame_Shift_Ins_p.R302fs|UBC_uc001ugt.2_Frame_Shift_Ins_p.R302fs|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Frame_Shift_Ins_p.R150fs	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	302	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CATCCCACCTCTGAGACGGAGC	0.53			NA											11	233	---	---	---	---	NA	NA	NA	NA	NA
RIF1	55183	broad.mit.edu	37	2	152330523	152330524	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7149-01A-11D-2036-08	TCGA-78-7149-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b4e21232-2edd-413b-aca5-f1db86fbdda9	0fd5c9a4-bf18-487c-8ada-873b032ac3da	g.chr2:152330523_152330524insA	uc002txm.2	+	35	7271_7272	c.7141_7142insA	c.(7141-7143)GAAfs	p.E2381fs	RIF1_uc002txl.2_Frame_Shift_Ins_p.E2355fs|RIF1_uc002txn.2_Frame_Shift_Ins_p.E2355fs|RIF1_uc002txo.2_Frame_Shift_Ins_p.E2355fs|RIF1_uc002txp.2_RNA|uc010fnw.1_5'Flank	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2381	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TGATATTTCTGAAAAAACAGTA	0.317			NA											20	93	---	---	---	---	NA	NA	NA	NA	NA
