Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VPS13D	55187	broad.mit.edu	37	1	12408994	12408994	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:12408994A>G	uc001atv.2	+	45	9325	c.9184A>G	c.(9184-9186)ATG>GTG	p.M3062V	VPS13D_uc001atw.2_Missense_Mutation_p.M3037V|VPS13D_uc001atx.2_Missense_Mutation_p.M2249V	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3061					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGAGACACCAATGGAACTAAG	0.393			NA											10	55					0	0	0.008291	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12856112	12856112	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:12856112G>A	uc001auj.1	+	4	1495	c.1392G>A	c.(1390-1392)CCG>CCA	p.P464P		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	464											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCTCATCACCGTCTGAGGAAC	0.557			NA											12	127					0	0	0.00245	0	0
AIM1L	55057	broad.mit.edu	37	1	26648746	26648746	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:26648746G>A	uc001bmd.3	-	18	2101	c.1671C>T	c.(1669-1671)GCC>GCT	p.A557A		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	557	Ricin B-type lectin.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		GGCGGCTCTCGGCCCACAGCA	0.627			NA											14	63					0	0	0.00245	0	0
SLC44A5	204962	broad.mit.edu	37	1	75685020	75685020	+	Silent	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:75685020C>T	uc001dgu.2	-	16	1332	c.1188G>A	c.(1186-1188)GCG>GCA	p.A396A	SLC44A5_uc001dgt.2_Silent_p.A396A|SLC44A5_uc001dgs.2_Silent_p.A354A|SLC44A5_uc001dgr.2_Silent_p.A354A|SLC44A5_uc010oqz.1_Silent_p.A435A|SLC44A5_uc010ora.1_Silent_p.A390A|SLC44A5_uc010orb.1_Silent_p.A266A	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	396	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CCCCCGATGTCGCCAAGAAAC	0.393			NA											7	20					0	0	0.001984	0	0
KCNA3	3738	broad.mit.edu	37	1	111216654	111216654	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:111216654G>A	uc001dzv.1	-	1	1002	c.778C>T	c.(778-780)CGC>TGC	p.R260C		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	260						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTCGTCGCGGAACTCCGGC	0.667			NA											4	57					0	0	0.009096	0	0
TBX15	6913	broad.mit.edu	37	1	119441710	119441710	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:119441710C>A	uc001ehl.1	-	7	962	c.647G>T	c.(646-648)TGG>TTG	p.W216L	TBX15_uc009whj.1_Missense_Mutation_p.W7L	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	322						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AGGAGGTCTCCAGAATGCATA	0.468			NA											13	18					0.00136819	0.00146405	0.013537	1	0
ITGA10	8515	broad.mit.edu	37	1	145530918	145530918	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:145530918G>T	uc001eoa.2	+	7	726	c.650G>T	c.(649-651)TGG>TTG	p.W217L	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.W86L|ITGA10_uc009wiw.2_Missense_Mutation_p.W74L|ITGA10_uc010oyw.1_Missense_Mutation_p.W162L	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	217	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTACATGAGTGGTCCCTGGGA	0.512			NA											20	37					3.51602e-12	4.15979e-12	0.008871	1	0
NBPF14	25832	broad.mit.edu	37	1	148009459	148009459	+	Silent	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:148009459A>G	uc001eqq.2	-	16	1865	c.1848T>C	c.(1846-1848)GAT>GAC	p.D616D	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Silent_p.D189D|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	616	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					AATAGCATCTATCCAGTGACT	0.483			NA											14	179					0	0	0.00245	0	0
FLG	2312	broad.mit.edu	37	1	152278890	152278890	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:152278890C>A	uc001ezu.1	-	3	8508	c.8472G>T	c.(8470-8472)AGG>AGT	p.R2824S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2824	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGCATCAGACCTTCCCTGGG	0.582			NA							Ichthyosis				16	469					6.44725e-10	7.57439e-10	0.014323	1	0
GON4L	54856	broad.mit.edu	37	1	155753800	155753800	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:155753800G>A	uc001flz.2	-	14	1966	c.1869C>T	c.(1867-1869)AAC>AAT	p.N623N	GON4L_uc001fly.1_Silent_p.N623N|GON4L_uc009wrh.1_Silent_p.N623N|GON4L_uc001fma.1_Silent_p.N623N|GON4L_uc001fmc.2_Silent_p.N623N|GON4L_uc001fmd.3_Silent_p.N623N|GON4L_uc009wri.2_Silent_p.N209N|GON4L_uc009wrj.1_Silent_p.N138N|GON4L_uc001fme.2_Silent_p.N451N	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	623					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGGTGTTAAAGTTAGGACGAG	0.448			NA											4	100					0	0	0.009096	0	0
KIFAP3	22920	broad.mit.edu	37	1	169923240	169923240	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:169923240C>T	uc001ggv.2	-	19	2456	c.2185G>A	c.(2185-2187)GCC>ACC	p.A729T	KIFAP3_uc010plx.1_Missense_Mutation_p.A431T	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	729					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCTTCAGAGGCAATTAATCCA	0.348			NA											52	65					0	0	0.01441	0	0
MYOC	4653	broad.mit.edu	37	1	171621223	171621223	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr1:171621223C>A	uc001ghu.2	-	1	551	c.529G>T	c.(529-531)GTA>TTA	p.V177L	MYOC_uc010pmk.1_Missense_Mutation_p.V119L	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	177	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGCCTTGCTACCTCCTGGCTG	0.572			NA											14	355					1.05317e-09	1.2287e-09	0.00245	1	0
IL15RA	3601	broad.mit.edu	37	10	5998369	5998369	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:5998369G>C	uc001iiv.2	-	6	747	c.665C>G	c.(664-666)TCT>TGT	p.S222C	IL15RA_uc001iiu.2_Missense_Mutation_p.S70C|IL15RA_uc010qau.1_Missense_Mutation_p.S189C|IL15RA_uc001iiw.2_Missense_Mutation_p.S186C|IL15RA_uc001iix.2_Missense_Mutation_p.S153C|IL15RA_uc001iiy.2_Missense_Mutation_p.S70C	NM_002189	NP_002180	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha isoform 1	222	Helical; (Potential).				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity				0						TGCCAGGAGAGACACAGCGCT	0.512			NA											3	30					0	0	0.004672	0	0
ITGA8	8516	broad.mit.edu	37	10	15760899	15760899	+	Splice_Site	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:15760899C>G	uc001ioc.1	-	2	210	c.210_splice	c.e2-1	p.T70_splice	ITGA8_uc010qcb.1_Splice_Site_p.T70_splice	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor						cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GACACTCGCTCTGCAAAAGAG	0.607			NA											5	67					0	0	0.000602	0	0
MYO3A	53904	broad.mit.edu	37	10	26462857	26462857	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:26462857G>C	uc001isn.2	+	30	4024	c.3664G>C	c.(3664-3666)GAA>CAA	p.E1222Q	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1222					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CAAAGACCTGGAAGAGAACAG	0.413			NA											9	52					0	0	0.008291	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315685	30315685	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:30315685C>T	uc001iux.2	-	2	3451	c.3392G>A	c.(3391-3393)CGC>CAC	p.R1131H	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.R993H|KIAA1462_uc009xle.1_Missense_Mutation_p.R1131H	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1131										ovary(4)	4						CGGTGCTGGGCGAGATAGCAA	0.632			NA											10	95					0	0	0.008291	0	0
C10orf81	79949	broad.mit.edu	37	10	115534042	115534042	+	Silent	SNP	A	A	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:115534042A>C	uc001lat.1	+	8	1273	c.711A>C	c.(709-711)CCA>CCC	p.P237P	C10orf81_uc001lar.1_Silent_p.P243P|C10orf81_uc009xyc.1_Silent_p.P155P|C10orf81_uc001las.1_Silent_p.P155P|C10orf81_uc001lau.1_Silent_p.P57P	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	237										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		CTGATGGTCCAGACCAGGTCT	0.383			NA											4	38					0	0	0.009096	0	0
VWA2	340706	broad.mit.edu	37	10	116032545	116032545	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:116032545A>T	uc001lbl.1	+	6	739	c.418A>T	c.(418-420)AGA>TGA	p.R140*	VWA2_uc001lbk.1_Nonsense_Mutation_p.R140*|VWA2_uc009xyf.1_5'UTR	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	140	VWFA 1.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		CCTTCTGCACAGAGGGTTGCC	0.537			NA											18	70					0	0	0.006122	0	0
C10orf84	63877	broad.mit.edu	37	10	120095846	120095846	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:120095846A>G	uc001ldo.2	-	3	349	c.82T>C	c.(82-84)TCT>CCT	p.S28P	C10orf84_uc010qss.1_Missense_Mutation_p.S28P	NM_022063	NP_071346	Q9H8W3	F204A_HUMAN	hypothetical protein LOC63877	28											0		Colorectal(252;0.101)		all cancers(201;0.0244)		TTAAGTCCAGAGTTCTCCAAC	0.408			NA											6	60					0	0	0.001168	0	0
TCERG1L	256536	broad.mit.edu	37	10	133106605	133106605	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr10:133106605T>A	uc001lkp.2	-	3	625	c.539A>T	c.(538-540)GAG>GTG	p.E180V		NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	180	WW 1.									large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CCTTGACTCCTCAGGATGTAT	0.473			NA											8	38					0	0	0.00308	0	0
OR52K2	119774	broad.mit.edu	37	11	4470612	4470612	+	Silent	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:4470612T>C	uc001lyz.1	+	1	43	c.43T>C	c.(43-45)TTG>CTG	p.L15L		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACTGCCTTCTTGTTGGTGGG	0.507			NA											9	60					0	0	0.006214	0	0
OR51T1	401665	broad.mit.edu	37	11	4903745	4903745	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:4903745C>A	uc010qyp.1	+	1	697	c.697C>A	c.(697-699)CTC>ATC	p.L233I		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTTTCTTCAGCTCTACCTGAA	0.453			NA											25	61					3.83957e-06	4.27184e-06	0.00278	1	0
OR52J3	119679	broad.mit.edu	37	11	5068178	5068178	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:5068178A>T	uc010qyv.1	+	1	423	c.423A>T	c.(421-423)CAA>CAT	p.Q141H		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGACATCCCAAGTGTTGGTGG	0.488			NA											9	40					0	0	0.006214	0	0
OR4C16	219428	broad.mit.edu	37	11	55339872	55339872	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:55339872T>A	uc010rih.1	+	1	269	c.269T>A	c.(268-270)ATC>AAC	p.I90N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				AAGACAACTATCTCCTTCAGC	0.448			NA											70	109					0	0	0.01441	0	0
SDHAF2	54949	broad.mit.edu	37	11	61205550	61205550	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:61205550C>G	uc001nrt.2	+	3	357	c.335C>G	c.(334-336)CCT>CGT	p.P112R		NM_017841	NP_060311	Q9NX18	SDHF2_HUMAN	succinate dehydrogenase complex assembly factor	112					mitochondrial electron transport, succinate to ubiquinone|protein-FAD linkage	mitochondrion	protein binding			ovary(2)	2						ATTAACGAGCCTAGTAATGAC	0.388			NA							Familial_Paragangliomas				17	24					0	0	0.010504	0	0
DAGLA	747	broad.mit.edu	37	11	61508674	61508674	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:61508674C>T	uc001nsa.2	+	19	2135	c.2024C>T	c.(2023-2025)TCT>TTT	p.S675F		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	675	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GCTCTGCTCTCTGCAGCCAAG	0.647			NA											5	74					0	0	0.001168	0	0
GANAB	23193	broad.mit.edu	37	11	62393613	62393613	+	Silent	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:62393613A>G	uc001nub.2	-	23	2682	c.2649T>C	c.(2647-2649)TTT>TTC	p.F883F	GANAB_uc001ntz.2_Silent_p.F70F|GANAB_uc001nua.2_Silent_p.F905F|GANAB_uc001nuc.2_Silent_p.F786F|GANAB_uc010rma.1_Silent_p.F791F|GANAB_uc010rmb.1_Silent_p.F769F	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	883					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TTGGTGTCTCAAAGTGTCCTT	0.512	Melanoma(23;1005 1074 15747 18937)		NA											15	215					0	0	0.003163	0	0
HYOU1	10525	broad.mit.edu	37	11	118925328	118925328	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:118925328G>A	uc001puu.2	-	7	749	c.556C>T	c.(556-558)CGA>TGA	p.R186*	HYOU1_uc001put.2_Nonsense_Mutation_p.R151*|HYOU1_uc010ryu.1_Nonsense_Mutation_p.R206*|HYOU1_uc010ryv.1_Nonsense_Mutation_p.R75*|HYOU1_uc001pux.3_Nonsense_Mutation_p.R186*|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Nonsense_Mutation_p.R186*	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	186						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		AGCACAGCTCGGCGCTCGGCC	0.587			NA											6	47					0	0	0.001168	0	0
FGD6	55785	broad.mit.edu	37	12	95603382	95603382	+	Missense_Mutation	SNP	G	G	A	rs149076340	byFrequency	TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr12:95603382G>A	uc001tdp.3	-	2	1902	c.1678C>T	c.(1678-1680)CGG>TGG	p.R560W	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	560					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						TCTGAAGCCCGTTTAGGCATA	0.423			NA											4	95					0	0	0.000602	0	0
C12orf63	374467	broad.mit.edu	37	12	97102464	97102464	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr12:97102464A>G	uc001tet.1	+	15	1960	c.1882A>G	c.(1882-1884)AAT>GAT	p.N628D		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	628										skin(6)|ovary(1)	7						AAATAAGTTTAATTTTGTTAA	0.323			NA											5	26					0	0	0.000602	0	0
FOXN4	121643	broad.mit.edu	37	12	109719362	109719362	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr12:109719362G>T	uc001toe.3	-	9	1249	c.1144C>A	c.(1144-1146)CCG>ACG	p.P382T	FOXN4_uc009zvg.2_Missense_Mutation_p.P179T|FOXN4_uc001tof.3_Missense_Mutation_p.P202T	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	382					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						TGCAGTGGCGGGGTCTGGGCT	0.657			NA											7	14					0.00198382	0.00209611	0.001984	1	0
RAB35	11021	broad.mit.edu	37	12	120536884	120536884	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr12:120536884C>T	uc001txm.1	-	4	447	c.302G>A	c.(301-303)CGG>CAG	p.R101Q	RAB35_uc010szg.1_5'UTR|RAB35_uc009zww.1_5'UTR|RAB35_uc010szh.1_Missense_Mutation_p.R101Q	NM_006861	NP_006852	Q15286	RAB35_HUMAN	RAB35, member RAS oncogene family	101					cytokinesis|endosome transport|protein transport|small GTPase mediated signal transduction	cell projection membrane|clathrin-coated endocytic vesicle|coated pit|endosome|intercellular bridge|melanosome	GTP binding|GTPase activity|phosphatidylinositol-4,5-bisphosphate binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.248)		GTGAAGCCACCGCTTGACGTT	0.587			NA											8	60					0	0	0.00308	0	0
ZNF268	10795	broad.mit.edu	37	12	133779003	133779003	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr12:133779003T>C	uc010tcf.1	+	6	1061	c.731T>C	c.(730-732)ATT>ACT	p.I244T	ZNF268_uc010tbv.1_Missense_Mutation_p.I83T|ZNF268_uc010tbw.1_Missense_Mutation_p.I83T|ZNF268_uc010tbx.1_Missense_Mutation_p.I104T|ZNF268_uc010tby.1_Missense_Mutation_p.I83T|ZNF268_uc010tbz.1_Missense_Mutation_p.I83T|ZNF268_uc010tca.1_Missense_Mutation_p.I83T|ZNF268_uc010tcb.1_Missense_Mutation_p.I104T|ZNF268_uc010tcc.1_Missense_Mutation_p.I83T|ZNF268_uc010tcd.1_Missense_Mutation_p.I83T|ZNF268_uc010tce.1_Missense_Mutation_p.I83T|ZNF268_uc010tcg.1_Missense_Mutation_p.I83T|ZNF268_uc010tch.1_Missense_Mutation_p.I244T	NM_003415	NP_003406	Q14587	ZN268_HUMAN	zinc finger protein 268 isoform a	244						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CAAACTGTTATTGGAATAAAA	0.323			NA											5	8					0	0	0.000602	0	0
STOML3	161003	broad.mit.edu	37	13	39544447	39544447	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr13:39544447C>T	uc001uwx.2	-	5	529	c.391G>A	c.(391-393)GCT>ACT	p.A131T	STOML3_uc010tez.1_Missense_Mutation_p.A122T	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	131	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		TTGACATTAGCCACTGCTGAG	0.468			NA											26	82					0	0	0.004656	0	0
KLHL1	57626	broad.mit.edu	37	13	70413107	70413107	+	Splice_Site	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr13:70413107C>G	uc001vip.2	-	6	2208	c.1414_splice	c.e6+1	p.G472_splice	KLHL1_uc010thm.1_Splice_Site_p.G411_splice	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein						actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GAATTAAATACCTTTGTTGTT	0.343			NA											16	19					0	0	0.006122	0	0
FERMT2	10979	broad.mit.edu	37	14	53325101	53325101	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr14:53325101C>A	uc001xad.2	-	15	2092	c.2037G>T	c.(2035-2037)TGG>TGT	p.W679C	FERMT2_uc001xac.2_Missense_Mutation_p.W686C|FERMT2_uc001xae.2_Missense_Mutation_p.W679C	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	679					actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					CTATTCACACCCAACCACTGG	0.343			NA											4	47					0.000602214	0.000656961	0.000602	1	0
HSPA2	3306	broad.mit.edu	37	14	65008152	65008152	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr14:65008152G>A	uc001xhj.2	+	2	661	c.585G>A	c.(583-585)GAG>GAA	p.E195E	HSPA2_uc001xhk.3_Silent_p.E195E	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	195					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CGGGCGGCGAGAAGAACGTGC	0.637	Pancreas(136;1211 1835 24894 31984 38227)		NA											11	121					0	0	0.013537	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68260457	68260457	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr14:68260457C>T	uc001xka.2	-	14	2560	c.2421G>A	c.(2419-2421)ATG>ATA	p.M807I	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.M807I	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	807					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCCGGCCAGACATGGCACTCA	0.522			NA											4	45					0	0	0.009096	0	0
EXD1	161829	broad.mit.edu	37	15	41476627	41476627	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr15:41476627C>G	uc001znk.2	-	10	1238	c.1047G>C	c.(1045-1047)GAG>GAC	p.E349D	EXD1_uc001znj.2_Missense_Mutation_p.E147D|EXD1_uc010ucv.1_Missense_Mutation_p.E407D	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	349					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						CTTTGACTTTCTCCTCTTTCC	0.398			NA											12	83					0	0	0.013537	0	0
ADAL	161823	broad.mit.edu	37	15	43627963	43627963	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr15:43627963G>T	uc010udo.1	+	5	707	c.133G>T	c.(133-135)GAT>TAT	p.D45Y	ADAL_uc001zrh.2_Missense_Mutation_p.D45Y	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	45					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		CCAGAAGCCAGATCTTAAAAT	0.383			NA											7	31					0.00198382	0.00209611	0.001984	1	0
PSMA4	5685	broad.mit.edu	37	15	78836557	78836557	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr15:78836557A>T	uc002bdu.3	+	5	393	c.235A>T	c.(235-237)ATA>TTA	p.I79L	PSMA4_uc010blf.2_Missense_Mutation_p.I79L|PSMA4_uc002bdv.3_Missense_Mutation_p.I8L|PSMA4_uc002bdw.3_Missense_Mutation_p.I55L|PSMA4_uc002bdx.3_Missense_Mutation_p.I8L	NM_002789	NP_002780	P25789	PSA4_HUMAN	proteasome alpha 4 subunit isoform 1	79					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0						TGTGGCAGGCATAACTTCTGA	0.358			NA											4	15					0	0	0.000602	0	0
TBC1D24	57465	broad.mit.edu	37	16	2549370	2549370	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:2549370G>A	uc002cql.2	+	5	1295	c.1155G>A	c.(1153-1155)CAG>CAA	p.Q385Q	TBC1D24_uc002cqk.2_Silent_p.Q379Q|TBC1D24_uc002cqm.2_Intron|TBC1D24_uc010bsm.2_Intron	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	385	TLD.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						TCTACTTCCAGTGTGAAGGAC	0.642			NA											3	29					0	0	0.004672	0	0
XYLT1	64131	broad.mit.edu	37	16	17221526	17221526	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:17221526G>A	uc002dfa.2	-	10	2305	c.2220C>T	c.(2218-2220)TCC>TCT	p.S740S		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	740	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CTCTTACCTCGGAAAACTGAA	0.488			NA											15	142					0	0	0.004007	0	0
XYLT1	64131	broad.mit.edu	37	16	17292086	17292086	+	Silent	SNP	C	C	T	rs144531370		TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:17292086C>T	uc002dfa.2	-	5	1357	c.1272G>A	c.(1270-1272)GCG>GCA	p.A424A		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	424	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GGTAGTCGGCCGCACTCAGGT	0.622			NA											14	40					0	0	0.00245	0	0
SRCAP	10847	broad.mit.edu	37	16	30740307	30740307	+	Silent	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:30740307G>T	uc002dze.1	+	26	6064	c.5679G>T	c.(5677-5679)CGG>CGT	p.R1893R	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.R1688R	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1893					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGGAAAAGCGGAAGCGGCAGC	0.527			NA											20	80					1.28384e-07	1.47729e-07	0.012319	1	0
SLC9A5	6553	broad.mit.edu	37	16	67290871	67290871	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:67290871T>C	uc002esm.2	+	7	1253	c.1190T>C	c.(1189-1191)ATT>ACT	p.I397T	SLC9A5_uc010cee.2_Missense_Mutation_p.I102T|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	397					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CTGGACAAGATTGACCAAGTG	0.592			NA											10	96					0	0	0.013537	0	0
PLCG2	5336	broad.mit.edu	37	16	81960739	81960739	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:81960739G>A	uc002fgt.2	+	23	2622	c.2470G>A	c.(2470-2472)GTC>ATC	p.V824I		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	824	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						ATCCAACTACGTCGAGGACAT	0.522			NA											8	148					0	0	0.004482	0	0
SERPINF1	5176	broad.mit.edu	37	17	1675164	1675164	+	Splice_Site	SNP	A	A	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:1675164A>C	uc002ftl.2	+	5	597	c.440_splice	c.e5-2	p.K147_splice	SERPINF1_uc010cjw.2_Splice_Site	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade						cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						GCCTCTTCTCAGAGCTGCGCA	0.572			NA											3	28					0	0	0.000602	0	0
WSCD1	23302	broad.mit.edu	37	17	5991404	5991404	+	Silent	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:5991404C>T	uc010cli.2	+	3	901	c.522C>T	c.(520-522)TGC>TGT	p.C174C	WSCD1_uc002gcn.2_Silent_p.C174C|WSCD1_uc002gco.2_Silent_p.C174C|WSCD1_uc010clj.2_Intron	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	174	WSC 1.					integral to membrane	sulfotransferase activity				0						TCTCCCACTGCCAGGATGCGT	0.542			NA											7	64					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GTCCTGCGTCTGAGAGGTGGT	0.542			NA											6	95					0	0	0.001168	0	0
NLE1	54475	broad.mit.edu	37	17	33467047	33467047	+	Silent	SNP	A	A	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:33467047A>C	uc002hiy.1	-	3	229	c.201T>G	c.(199-201)GCT>GCG	p.A67A	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	67						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				AGACGATCTCAGCATCGTGGA	0.552			NA											10	27					0	0	0.006214	0	0
VAT1	10493	broad.mit.edu	37	17	41170197	41170197	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:41170197G>A	uc002icm.1	-	3	742	c.622C>T	c.(622-624)CTG>TTG	p.L208L	VAT1_uc010cyw.1_Silent_p.L74L|VAT1_uc010whk.1_Silent_p.L140L	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	208				QL -> HV (in Ref. 7; AAA95990).		cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GTACGGCACAGCTGCACGGCA	0.587			NA											10	80					0	0	0.008291	0	0
SP2	6668	broad.mit.edu	37	17	45994184	45994184	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:45994184G>A	uc002imk.2	+	3	884	c.747G>A	c.(745-747)AAG>AAA	p.K249K	SP2_uc002iml.2_Silent_p.K242K|uc002imm.2_Intron	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	249					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0						AAGCAAGGAAGAAGAGCCTTC	0.582			NA											12	133					0	0	0.013537	0	0
SPATA20	64847	broad.mit.edu	37	17	48627386	48627386	+	Silent	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:48627386A>G	uc002irf.2	+	7	996	c.855A>G	c.(853-855)CGA>CGG	p.R285R	SPATA20_uc002irc.2_5'UTR|SPATA20_uc002ire.2_Silent_p.R241R|SPATA20_uc002ird.2_Silent_p.R301R|SPATA20_uc010wmv.1_Silent_p.R311R|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	285					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			TCAGCCATCGACTGACTCAGG	0.592			NA											28	346					0	0	0.00632	0	0
KIF2B	84643	broad.mit.edu	37	17	51900728	51900728	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:51900728G>A	uc002iua.2	+	1	490	c.334G>A	c.(334-336)GCC>ACC	p.A112T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	112					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CCAGCGTACCGCCACGAAATG	0.602			NA											9	147					0	0	0.004482	0	0
KIF2B	84643	broad.mit.edu	37	17	51900914	51900914	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:51900914C>T	uc002iua.2	+	1	676	c.520C>T	c.(520-522)CGC>TGC	p.R174C	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	174	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CCGAGCTAGACGCGCCCTCGA	0.542			NA											5	112					0	0	0.001168	0	0
PITPNC1	26207	broad.mit.edu	37	17	65688891	65688891	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr17:65688891C>T	uc002jgc.2	+	9	1233	c.886C>T	c.(886-888)CGG>TGG	p.R296W	PITPNC1_uc002jgb.2_3'UTR	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	296					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			AGATCGGCCCCGGAAAAAGTC	0.562			NA											12	89					0	0	0.013537	0	0
LONP1	9361	broad.mit.edu	37	19	5700829	5700829	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:5700829C>T	uc002mcx.2	-	9	1510	c.1477G>A	c.(1477-1479)GGC>AGC	p.G493S	LONP1_uc002mcy.2_Missense_Mutation_p.G429S|LONP1_uc010duh.2_Missense_Mutation_p.G234S|LONP1_uc010dui.2_Missense_Mutation_p.G477S|LONP1_uc002mcz.2_Missense_Mutation_p.G297S	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	493					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						TCCTCCATGCCGTAGTGGTCT	0.602			NA											4	64					0	0	0.009096	0	0
PNPLA6	10908	broad.mit.edu	37	19	7614968	7614968	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:7614968T>G	uc010xjq.1	+	16	2006	c.1811T>G	c.(1810-1812)TTC>TGC	p.F604C	PNPLA6_uc002mgq.1_Missense_Mutation_p.F556C|PNPLA6_uc010xjp.1_Missense_Mutation_p.F530C|PNPLA6_uc002mgr.1_Missense_Mutation_p.F556C|PNPLA6_uc002mgs.2_Missense_Mutation_p.F595C	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	595	cNMP 2.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						GACTGCACCTTCCTGCGGATC	0.627			NA											7	79					0	0	0.00308	0	0
KEAP1	9817	broad.mit.edu	37	19	10610361	10610361	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:10610361C>T	uc002moq.1	-	2	505	c.349G>A	c.(349-351)GAG>AAG	p.E117K	KEAP1_uc002mor.1_Missense_Mutation_p.E117K	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	117	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATGCCCTGCTCCCGCAGCCCG	0.607			NA											8	34					0	0	0.00308	0	0
SPINT2	10653	broad.mit.edu	37	19	38774333	38774333	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:38774333T>C	uc002ohr.1	+	2	504	c.173T>C	c.(172-174)GTC>GCC	p.V58A	SPINT2_uc002ohs.1_Intron	NM_021102	NP_066925	O43291	SPIT2_HUMAN	serine protease inhibitor, Kunitz type, 2	58	Extracellular (Potential).|BPTI/Kunitz inhibitor 1.				cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity				0	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TGGTACAATGTCACTGACGGA	0.552			NA											6	111					0	0	0.001984	0	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627			NA											8	30					0	0	0.003163	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49379184	49379184	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:49379184C>T	uc002pky.3	+	3	2248	c.1979C>T	c.(1978-1980)TCT>TTT	p.S660F		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	660					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		TCCCGCTCGTCTGCTGCTGCA	0.562			NA											14	158					0	0	0.001855	0	0
OTOF	9381	broad.mit.edu	37	2	26705336	26705336	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:26705336T>C	uc002rhk.2	-	14	1644	c.1517A>G	c.(1516-1518)AAC>AGC	p.N506S		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	506	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCACGTCGTTGACCTTGTC	0.577	GBM(102;732 1451 20652 24062 31372)		NA											19	82					0	0	0.006122	0	0
MAPRE3	22924	broad.mit.edu	37	2	27248599	27248599	+	Silent	SNP	C	C	T	rs139273861	by1000genomes	TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:27248599C>T	uc002rhw.2	+	5	771	c.618C>T	c.(616-618)AAC>AAT	p.N206N	MAPRE3_uc002rhx.2_Silent_p.N191N	NM_012326	NP_036458	Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family,	206	EB1 C-terminal.				cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGAACTCAACCAACAGGTGA	0.597			NA											4	54					0	0	0.000602	0	0
RGPD3	653489	broad.mit.edu	37	2	107041237	107041237	+	Silent	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:107041237T>A	uc010ywi.1	-	20	3243	c.3186A>T	c.(3184-3186)TCA>TCT	p.S1062S		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1062	RanBD1 1.				intracellular transport		binding			ovary(1)	1						TTACCCCCTGTGAATACAGAA	0.398			NA											59	362					0	0	0.01441	0	0
PCDP1	200373	broad.mit.edu	37	2	120388402	120388402	+	Silent	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:120388402C>A	uc002tmb.2	+	20	2133	c.1041C>A	c.(1039-1041)GGC>GGA	p.G347G	PCDP1_uc010yyq.1_Silent_p.G477G	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	633						cilium	calmodulin binding				0	Colorectal(110;0.196)					AGCTCTCTGGCAAAACATCAG	0.473			NA											12	73					2.27111e-07	2.59555e-07	0.013537	1	0
SLC40A1	30061	broad.mit.edu	37	2	190428871	190428871	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:190428871C>G	uc002uqp.3	-	7	1192	c.841G>C	c.(841-843)GAG>CAG	p.E281Q		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	281					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CAAGTAGGCTCTTGCTCATGT	0.498			NA											9	48					0	0	0.004482	0	0
PARD3B	117583	broad.mit.edu	37	2	206166352	206166352	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:206166352G>A	uc002var.1	+	18	2764	c.2557G>A	c.(2557-2559)GAG>AAG	p.E853K	PARD3B_uc010fub.1_Missense_Mutation_p.E853K|PARD3B_uc002vao.1_Missense_Mutation_p.E853K|PARD3B_uc002vap.1_Missense_Mutation_p.E791K|PARD3B_uc002vaq.1_Missense_Mutation_p.E784K	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	853	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		gaaagtcaaggagaaaaagcg	0.244			NA											6	30					0	0	0.001168	0	0
DNER	92737	broad.mit.edu	37	2	230456436	230456436	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr2:230456436C>G	uc002vpv.2	-	2	592	c.445G>C	c.(445-447)GCA>CCA	p.A149P		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	149	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGTCGGGGTGCCATGGATTCG	0.557			NA											4	37					0	0	0.009096	0	0
PSMF1	9491	broad.mit.edu	37	20	1108107	1108107	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:1108107C>G	uc002wel.3	+	4	489	c.321C>G	c.(319-321)AAC>AAG	p.N107K	PSMF1_uc010zpo.1_Missense_Mutation_p.N19K|PSMF1_uc002wem.3_Missense_Mutation_p.N107K|PSMF1_uc010zpp.1_Missense_Mutation_p.N107K|PSMF1_uc002wen.3_Missense_Mutation_p.N107K	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	107					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						TGACCCTGAACTTGGATGATT	0.448			NA											45	108					0	0	0.01441	0	0
ADAM33	80332	broad.mit.edu	37	20	3652284	3652284	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:3652284G>T	uc002wit.2	-	16	1936	c.1849C>A	c.(1849-1851)CTG>ATG	p.L617M	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Missense_Mutation_p.L617M|ADAM33_uc002wis.2_Missense_Mutation_p.L139M|ADAM33_uc002wiu.2_Missense_Mutation_p.L617M|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Missense_Mutation_p.L133M	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	617	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						AGCAGGTCCAGCTGGGCACTG	0.637			NA											4	6					2.56e-06	2.88644e-06	0.009096	1	0
NCOA3	8202	broad.mit.edu	37	20	46264276	46264276	+	Silent	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:46264276A>G	uc002xtk.2	+	11	1528	c.1323A>G	c.(1321-1323)TCA>TCG	p.S441S	NCOA3_uc010ght.1_Silent_p.S451S|NCOA3_uc002xtl.2_Silent_p.S441S|NCOA3_uc002xtm.2_Silent_p.S441S|NCOA3_uc002xtn.2_Silent_p.S441S|NCOA3_uc010zyc.1_Silent_p.S236S	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	441					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						ACATAGCTTCATTGACCCCTG	0.562			NA											15	199					0	0	0.003163	0	0
DDX27	55661	broad.mit.edu	37	20	47836000	47836000	+	Silent	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:47836000C>G	uc002xuh.2	+	1	169	c.108C>G	c.(106-108)CTC>CTG	p.L36L		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	36						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTGCGGACCTCGGCTTAATCG	0.602			NA											3	37					0	0	0.004672	0	0
VAPB	9217	broad.mit.edu	37	20	56993313	56993313	+	Silent	SNP	G	G	A	rs141383583		TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:56993313G>A	uc002xza.2	+	2	376	c.105G>A	c.(103-105)CCG>CCA	p.P35P	VAPB_uc002xzb.2_RNA|VAPB_uc010zzo.1_5'UTR|VAPB_uc002xzc.2_Silent_p.P35P	NM_004738	NP_004729	O95292	VAPB_HUMAN	VAMP-associated protein B/C	35	Cytoplasmic (Potential).|MSP.				cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(1)	1	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			TTGGCAACCCGACAGACCGAA	0.493			NA											15	488					0	0	0.00245	0	0
TAF4	6874	broad.mit.edu	37	20	60589671	60589671	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:60589671G>C	uc002ybs.2	-	2	1453	c.1453C>G	c.(1453-1455)CAG>GAG	p.Q485E		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	485					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			ATGGTGGTCTGAGGCTGGGCA	0.632			NA											8	63					0	0	0.00308	0	0
SAMD10	140700	broad.mit.edu	37	20	62608328	62608328	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr20:62608328G>A	uc002yhm.2	-	3	616	c.441C>T	c.(439-441)ATC>ATT	p.I147I	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	147	SAM.										0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CTGTACCGGTGATGGCATGCT	0.592			NA											40	112					0	0	0.00623	0	0
EIF3D	8664	broad.mit.edu	37	22	36915565	36915565	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr22:36915565C>T	uc003apq.2	-	8	714	c.598G>A	c.(598-600)GAA>AAA	p.E200K	EIF3D_uc011amr.1_Missense_Mutation_p.E27K|EIF3D_uc003apr.2_Missense_Mutation_p.E200K|EIF3D_uc011ams.1_Missense_Mutation_p.E103K|EIF3D_uc011amt.1_Missense_Mutation_p.E151K	NM_003753	NP_003744	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3	200						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			pancreas(1)	1						TCGTAGTATTCTAGGGCCCCA	0.507			NA											12	73					0	0	0.013537	0	0
CYTH4	27128	broad.mit.edu	37	22	37692042	37692042	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr22:37692042G>A	uc003arf.2	+	4	286	c.170G>A	c.(169-171)CGG>CAG	p.R57Q	CYTH4_uc003ard.3_Missense_Mutation_p.R57Q|CYTH4_uc003are.2_Missense_Mutation_p.R57Q|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	57	Potential.|SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GTCCACAGCCGGATGGCCCAG	0.627			NA											3	18					0	0	0.004672	0	0
NOL12	79159	broad.mit.edu	37	22	38084913	38084913	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr22:38084913G>A	uc003atp.2	+	4	351	c.295G>A	c.(295-297)GAC>AAC	p.D99N	NOL12_uc011anm.1_Missense_Mutation_p.D99N|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	99						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					GGTGCAGTATGACCACCCCAA	0.632			NA											10	137					0	0	0.008291	0	0
WNT7B	7477	broad.mit.edu	37	22	46345949	46345949	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr22:46345949G>A	uc003bgo.2	-	2	523	c.149C>T	c.(148-150)GCC>GTC	p.A50V	WNT7B_uc010haa.2_Missense_Mutation_p.A54V	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	50					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CTGGCAGATGGCACGCTGCCG	0.622			NA											5	33					0	0	0.000602	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266100	41266101	+	Missense_Mutation	DNP	TC	TC	AA	rs121913400		TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr3:41266100_41266101TC>AA	uc010hia.1	+	4	253_254	c.97_98TC>AA	c.(97-99)TCT>AAT	p.S33N	CTNNB1_uc003ckp.2_Missense_Mutation_p.S33N|CTNNB1_uc003ckq.2_Missense_Mutation_p.S33N|CTNNB1_uc003ckr.2_Missense_Mutation_p.S33N|CTNNB1_uc011azf.1_Missense_Mutation_p.S26N|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	33			S -> F (in PTR, MDB and hepatocellular carcinoma).|Missing (in hepatocellular carcinoma).|S -> Y (in colorectal cancer and PTR; enhances transactivation of target genes).|S -> L (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S33C(131)|p.S33F(79)|p.A5_A80del(63)|p.S33Y(52)|p.S33P(37)|p.S33A(14)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.S33L(4)|p.W25_D32del(4)|p.W25_I140del(4)|p.S33N(3)|p.S23_S33del(3)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.W25_H36del(2)|p.Y30_S33del(2)|p.V22_S33del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.S33T(1)|p.S33S(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S29_H36del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.W25_I35del(1)|p.V22_G80>NNNNN(1)|p.A5_I35del(1)|p.E9_A80del(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.W25_S33del(1)|p.V22_T102del(1)|p.S33_G34del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.D32_H36>D(1)|p.S33_G34insGTS(1)|p.P16_K133del(1)|p.A5_T59del(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.W25_A80del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.D32_S33insS(1)|p.S33_G34insS(1)|p.Y30_T40del(1)|p.S33_G34insGI(1)|p.M1_T42del(1)|p.A5_Q143>E(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.S23_I35del(1)|p.V22_S71>A(1)|p.V22_Y64del(1)|p.A20_Q72del(1)|p.A20_S111del(1)|p.D32_H36del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TTACCTGGACTCTGGAATCCAT	0.49	Colon(6;3 56 14213 18255)	S33C(SKMEL1_SKIN)|S33F(SW1573_LUNG)|S33Y(SW48_LARGE_INTESTINE)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				7	36					0	0	0.004672	0	0
DRD3	1814	broad.mit.edu	37	3	113850231	113850231	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr3:113850231G>A	uc003ebd.2	-	7	1163	c.740C>T	c.(739-741)CCG>CTG	p.P247L	DRD3_uc010hqn.1_Missense_Mutation_p.P247L|DRD3_uc003ebb.1_Missense_Mutation_p.P247L|DRD3_uc003ebc.1_Missense_Mutation_p.P247L	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	247	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CAGATGTGCCGGGTCAGGAGA	0.507			NA											4	74					0	0	0.000602	0	0
PIK3CA	5290	broad.mit.edu	37	3	178921404	178921404	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr3:178921404C>G	uc003fjk.2	+	5	1043	c.886C>G	c.(886-888)CAA>GAA	p.Q296E		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	296					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTTTATTCTCAACTGCCAAT	0.403	Colon(199;1504 1750 3362 26421 31210 32040)		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	45					0	0	0.001168	0	0
ZBTB49	166793	broad.mit.edu	37	4	4317644	4317644	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr4:4317644T>G	uc003ghu.2	+	7	1743	c.1568T>G	c.(1567-1569)GTA>GGA	p.V523G	ZBTB49_uc003ghv.2_Missense_Mutation_p.V6G|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	523	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGGAAGTTAGTAAAGCACAGA	0.478			NA											9	67					0	0	0.004482	0	0
AFF1	4299	broad.mit.edu	37	4	88035789	88035789	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr4:88035789C>T	uc003hqj.3	+	11	2190	c.1783C>T	c.(1783-1785)CCA>TCA	p.P595S	AFF1_uc011ccz.1_Missense_Mutation_p.P602S|AFF1_uc003hqk.3_Missense_Mutation_p.P595S|AFF1_uc011cda.1_Missense_Mutation_p.P233S	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	595						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCAGGAGCCCCCACAAAGGCA	0.637			NA											3	27					0	0	0.004672	0	0
FAM190A	401145	broad.mit.edu	37	4	91230645	91230645	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr4:91230645G>A	uc003hsv.3	+	2	1550	c.1210G>A	c.(1210-1212)GCG>ACG	p.A404T	FAM190A_uc003hsu.3_Missense_Mutation_p.A404T|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.A404T	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	404										large_intestine(1)|ovary(1)	2						TAAAGCAATAGCGGAACATGT	0.353			NA											21	61					0	0	0.00278	0	0
SLC39A8	64116	broad.mit.edu	37	4	103226270	103226270	+	Splice_Site	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr4:103226270T>A	uc003hwb.1	-	4	1082	c.553_splice	c.e4-1	p.A185_splice	SLC39A8_uc011ceo.1_Splice_Site_p.A185_splice|SLC39A8_uc003hwa.1_Splice_Site_p.A118_splice|SLC39A8_uc003hwc.2_Splice_Site_p.A185_splice	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),							integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		TCCAAATGCCTAAGGGAGAAA	0.353			NA											3	20					0	0	0.004672	0	0
FGG	2266	broad.mit.edu	37	4	155530801	155530801	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr4:155530801C>A	uc003ioj.2	-	6	788	c.647G>T	c.(646-648)GGA>GTA	p.G216V	FGG_uc003iog.2_Missense_Mutation_p.G216V|FGG_uc003ioh.2_Missense_Mutation_p.G224V|FGG_uc010ipx.2_Missense_Mutation_p.G44V|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.G224V	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	216	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CACAGTCCATCCATTTCCAGA	0.323			NA											4	55					0.00116845	0.00125833	0.001168	1	0
FGG	2266	broad.mit.edu	37	4	155530817	155530817	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr4:155530817C>T	uc003ioj.2	-	6	772	c.631G>A	c.(631-633)GAT>AAT	p.D211N	FGG_uc003iog.2_Missense_Mutation_p.D211N|FGG_uc003ioh.2_Missense_Mutation_p.D219N|FGG_uc010ipx.2_Missense_Mutation_p.D39N|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.D219N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	211	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CCAGACCCATCGATTTCACAG	0.348			NA											4	54					0	0	0.000602	0	0
MYO10	4651	broad.mit.edu	37	5	16674979	16674979	+	Silent	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:16674979G>C	uc003jft.3	-	35	5415	c.4947C>G	c.(4945-4947)CTC>CTG	p.L1649L	MYO10_uc011cnb.1_Silent_p.L278L|MYO10_uc011cnc.1_Silent_p.L528L|MYO10_uc011cnd.1_Silent_p.L1006L|MYO10_uc011cne.1_Silent_p.L1006L|MYO10_uc010itx.2_Silent_p.L1271L	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1649	MyTH4.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GATGGAACTTGAGATACTTGA	0.572			NA											9	157					0	0	0.006214	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54624545	54624545	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:54624545G>C	uc003jpy.3	+	5	687	c.421G>C	c.(421-423)GAT>CAT	p.D141H	SKIV2L2_uc011cqi.1_Missense_Mutation_p.D40H	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	141					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				GTTCATTCTTGATGCTTTTCA	0.373	Melanoma(2;92 134 23744 29976 33782)		NA											3	39					0	0	0.004672	0	0
APC	324	broad.mit.edu	37	5	112170861	112170861	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:112170861A>T	uc010jby.2	+	15	2337	c.1957A>T	c.(1957-1959)AGG>TGG	p.R653W	APC_uc011cvt.1_Missense_Mutation_p.R635W|APC_uc003kpz.3_Missense_Mutation_p.R653W|APC_uc003kpy.3_Missense_Mutation_p.R653W|APC_uc010jbz.2_Missense_Mutation_p.R370W|APC_uc010jca.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	653	Leu-rich.|ARM 5.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGAGGACCACAGGTATATATA	0.333	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			4	17					0	0	0.009096	0	0
FSTL4	23105	broad.mit.edu	37	5	132648445	132648445	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:132648445C>G	uc003kyn.1	-	6	846	c.628G>C	c.(628-630)GAT>CAT	p.D210H		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	210						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGTCTTCATCCAGGTCCTGC	0.512			NA											4	41					0	0	0.009096	0	0
PKD2L2	27039	broad.mit.edu	37	5	137230154	137230154	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:137230154G>A	uc003lby.2	+	4	436	c.380G>A	c.(379-381)GGA>GAA	p.G127E	PKD2L2_uc010jep.1_Missense_Mutation_p.G67E|PKD2L2_uc003lbw.1_Missense_Mutation_p.G127E|PKD2L2_uc003lbx.2_Missense_Mutation_p.G127E	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	127	Polycystin motif.|Extracellular (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATACTTCTAGGAGTTCCCAGA	0.383			NA											8	33					0	0	0.00308	0	0
SLC25A2	83884	broad.mit.edu	37	5	140682903	140682903	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:140682903A>C	uc003ljf.2	-	1	710	c.530T>G	c.(529-531)CTA>CGA	p.L177R		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	177	Helical; Name=4; (Potential).|Solcar 2.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TTCTTGAAGTAGAGTACTCGA	0.448			NA											5	110					0	0	0.000602	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149215969	149215969	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:149215969G>T	uc003lrc.2	+	8	1993	c.1951G>T	c.(1951-1953)GCC>TCC	p.A651S	PPARGC1B_uc003lrb.1_Missense_Mutation_p.A651S|PPARGC1B_uc003lrd.2_Missense_Mutation_p.A612S|PPARGC1B_uc003lrf.2_Missense_Mutation_p.A630S|PPARGC1B_uc003lre.1_Missense_Mutation_p.A630S	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	651					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CCCAGGGGCTGCCCACAAGCT	0.612			NA											9	112					2.17888e-05	2.40823e-05	0.006214	1	0
CCDC69	26112	broad.mit.edu	37	5	150565642	150565642	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr5:150565642G>T	uc003ltq.2	-	6	560	c.437C>A	c.(436-438)GCC>GAC	p.A146D	CCDC69_uc010jhu.2_5'UTR|CCDC69_uc011dcq.1_RNA	NM_015621	NP_056436	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	146	Potential.									ovary(2)	2		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTCATTTTGGCCTGGAAAGC	0.522			NA											11	176					4.68919e-08	5.43299e-08	0.008291	1	0
GPX5	2880	broad.mit.edu	37	6	28500162	28500162	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:28500162G>T	uc003nll.2	+	4	426	c.424G>T	c.(424-426)GGT>TGT	p.G142C	GPX5_uc003nlm.2_3'UTR|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	142					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	GGATGTGAATGGTGAAAAAGA	0.443			NA											5	44					0.00116845	0.00125833	0.001168	1	0
OR2J2	26707	broad.mit.edu	37	6	29141320	29141320	+	Translation_Start_Site	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:29141320T>A	uc011dlm.1	+	1	10	c.-92T>A	c.(-94--90)TTTTG>TTATG			NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGGATACTTTTGTCTTCAAT	0.358			NA											3	9					0	0	0.004672	0	0
MDC1	9656	broad.mit.edu	37	6	30675945	30675945	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:30675945C>A	uc003nrg.3	-	8	2851	c.2411G>T	c.(2410-2412)GGC>GTC	p.G804V	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Intron	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	804				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CCTCCCTCTGCCTTGAATCCC	0.532			NA						Other_conserved_DNA_damage_response_genes					38	111					1.30998e-17	1.56083e-17	0.005524	1	0
NOTCH4	4855	broad.mit.edu	37	6	32168902	32168902	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:32168902G>A	uc003obb.2	-	22	4270	c.4131C>T	c.(4129-4131)CTC>CTT	p.L1377L	NOTCH4_uc003oba.2_Silent_p.L40L|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1377	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ACCCAGCACTGAGGGAGTCGG	0.592			NA											6	66					0	0	0.001168	0	0
RGL2	5863	broad.mit.edu	37	6	33263525	33263525	+	Silent	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:33263525G>C	uc003odv.2	-	7	913	c.780C>G	c.(778-780)CTC>CTG	p.L260L	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Silent_p.L178L|RGL2_uc011drb.1_Silent_p.L178L	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	260	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						GGATCAAATTGAGAAAAAGTT	0.532			NA											3	48					0	0	0.004672	0	0
TAPBP	6892	broad.mit.edu	37	6	33272909	33272909	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:33272909T>C	uc003odx.1	-	4	896	c.725A>G	c.(724-726)GAT>GGT	p.D242G	TAPBP_uc010jus.1_Missense_Mutation_p.D260G|TAPBP_uc003ody.2_Missense_Mutation_p.D242G|TAPBP_uc003odz.2_Missense_Mutation_p.D242G|TAPBP_uc010jut.1_Missense_Mutation_p.D155G|TAPBP_uc011drc.1_Missense_Mutation_p.D242G	NM_003190	NP_003181	O15533	TPSN_HUMAN	tapasin isoform 1 precursor	242	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			ovary(1)	1						CTCATCATCATCCCAAGCAGC	0.592			NA											32	43					0	0	0.012213	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423463	33423463	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:33423463G>C	uc003oeq.2	+	2	854	c.586G>C	c.(586-588)GTG>CTG	p.V196L		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGAGCCCTGTGGGAGGGGA	0.438			NA											8	81					0	0	0.00308	0	0
CUL9	23113	broad.mit.edu	37	6	43171224	43171224	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:43171224C>T	uc003ouk.2	+	19	3994	c.3919C>T	c.(3919-3921)CGG>TGG	p.R1307W	CUL9_uc003oul.2_Missense_Mutation_p.R1307W|CUL9_uc010jyk.2_Missense_Mutation_p.R459W	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1307	DOC.				ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GCCACTGTTCCGGGAGCAGCT	0.612			NA											35	61					0	0	0.004289	0	0
ULBP2	80328	broad.mit.edu	37	6	150267642	150267642	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr6:150267642C>T	uc003qno.2	+	3	557	c.484C>T	c.(484-486)CAT>TAT	p.H162Y	ULBP2_uc011eeh.1_Missense_Mutation_p.H162Y|ULBP2_uc010kij.2_Missense_Mutation_p.H162Y	NM_025217	NP_079493	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2 precursor	162	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		GACAACGGTTCATCCTGGAGC	0.473			NA											18	92					0	0	0.006122	0	0
SDK1	221935	broad.mit.edu	37	7	4167093	4167093	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:4167093G>A	uc003smx.2	+	26	4043	c.3904G>A	c.(3904-3906)GAA>AAA	p.E1302K	SDK1_uc010kso.2_Missense_Mutation_p.E578K|SDK1_uc003smy.2_5'Flank	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1302	Fibronectin type-III 7.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ATCCGTGCCGGAACAGGACCA	0.537			NA											11	80					0	0	0.010729	0	0
HOXA11	3207	broad.mit.edu	37	7	27224464	27224464	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:27224464G>A	uc003syx.2	-	1	372	c.300C>T	c.(298-300)GCC>GCT	p.A100A	HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	100					branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						CAGGCACGCCGGCCGCGCTGG	0.672			NA	T	NUP98	CML								8	57					0	0	0.00308	0	0
AEBP1	165	broad.mit.edu	37	7	44152266	44152266	+	Missense_Mutation	SNP	C	C	T	rs144799697	byFrequency	TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:44152266C>T	uc003tkb.2	+	18	2632	c.2327C>T	c.(2326-2328)GCC>GTC	p.A776V	AEBP1_uc003tkc.3_Missense_Mutation_p.A351V|AEBP1_uc003tkd.2_Missense_Mutation_p.A26V	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	776	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TACGATATGGCCCGCACGCCT	0.652			NA											4	38					0	0	0.009096	0	0
PILRA	29992	broad.mit.edu	37	7	99987664	99987664	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:99987664C>T	uc003uuo.1	+	3	820	c.608C>T	c.(607-609)GCT>GTT	p.A203V	PILRA_uc011kjo.1_Intron|PILRA_uc003uup.1_Intron|PILRA_uc003uuq.1_Intron	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	203	Helical; (Potential).				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGGCAGTGGCTGTCACTGTG	0.582			NA											5	68					0	0	0.001168	0	0
RELN	5649	broad.mit.edu	37	7	103155858	103155858	+	Silent	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:103155858A>G	uc003vca.2	-	50	8053	c.7893T>C	c.(7891-7893)GCT>GCC	p.A2631A	RELN_uc010liz.2_Silent_p.A2631A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2631					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAATCTCTTTAGCATCAGGAG	0.483	NSCLC(146;835 1944 15585 22231 52158)		NA											3	41					0	0	0.000602	0	0
NDUFB2	4708	broad.mit.edu	37	7	140396598	140396598	+	Silent	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:140396598C>T	uc003vwa.2	+	1	118	c.54C>T	c.(52-54)TTC>TTT	p.F18F	LOC100134713_uc011krf.1_RNA|NDUFB2_uc010lnl.2_RNA	NM_004546	NP_004537	O95178	NDUB2_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	18					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.00956)				NADH(DB00157)	GCCGCCTTTTCAGAAGCGGCT	0.706			NA											4	16					0	0	0.000602	0	0
BRAF	673	broad.mit.edu	37	7	140481411	140481411	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr7:140481411C>G	uc003vwc.3	-	11	1458	c.1397G>C	c.(1396-1398)GGA>GCA	p.G466A		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	466	ATP (By similarity).|Protein kinase.		G -> V (in LNCR).|G -> A (in melanoma).|G -> E (in melanoma).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G466V(12)|p.G466E(5)|p.G466A(3)|p.G466R(2)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCCAAATGATCCAGATCCAAT	0.378	Colon(40;35 892 2973 5743 27438)	G466V(NCIH1666_LUNG)|G466V(CAL12T_LUNG)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				19	44					0	0	0.007413	0	0
RP1L1	94137	broad.mit.edu	37	8	10466111	10466111	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:10466111C>T	uc003wtc.2	-	4	5726	c.5497G>A	c.(5497-5499)GAA>AAA	p.E1833K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1833					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCTATGCCTTCGGCCCCATCA	0.627			NA											14	194					0	0	0.004007	0	0
EXTL3	2137	broad.mit.edu	37	8	28600645	28600645	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:28600645C>T	uc003xgz.1	+	6	3057	c.2464C>T	c.(2464-2466)CGG>TGG	p.R822W		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	822	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CCAGGCCATCCGGGACATGGT	0.493			NA											23	127					0	0	0.014323	0	0
ASH2L	9070	broad.mit.edu	37	8	37993278	37993278	+	Silent	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:37993278C>T	uc003xkt.3	+	14	1771	c.1713C>T	c.(1711-1713)AGC>AGT	p.S571S	ASH2L_uc011lbk.1_Silent_p.S432S|ASH2L_uc003xku.3_Silent_p.S477S|ASH2L_uc010lwa.2_Intron	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	571	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				TGTACAAGAGCTGCACGGTAC	0.408			NA											13	37					0	0	0.013537	0	0
CHD7	55636	broad.mit.edu	37	8	61748804	61748804	+	Silent	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:61748804C>T	uc003xue.2	+	16	4428	c.3951C>T	c.(3949-3951)CGC>CGT	p.R1317R		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1317	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGATGGTGCGCTGCTTGGACA	0.478			NA											9	147					0	0	0.006214	0	0
PABPC1	26986	broad.mit.edu	37	8	101733732	101733732	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:101733732A>G	uc003yjs.1	-	1	584	c.80T>C	c.(79-81)CTC>CCC	p.L27P	PABPC1_uc011lhc.1_Missense_Mutation_p.L27P|PABPC1_uc011lhd.1_Intron|PABPC1_uc003yjt.1_Missense_Mutation_p.L27P|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	27	RRM 1.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CTTCTCGTAGAGCATCGCCTC	0.667			NA											3	44					0	0	0.009096	0	0
FAM91A1	157769	broad.mit.edu	37	8	124792255	124792255	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:124792255G>C	uc003yqv.2	+	7	641	c.580G>C	c.(580-582)GAT>CAT	p.D194H	FAM91A1_uc011lik.1_Missense_Mutation_p.D194H|FAM91A1_uc011lil.1_5'UTR	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	194										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			ATGCGCTGTTGATAAGATCAT	0.328			NA											5	43					0	0	0.000602	0	0
NDUFB9	4715	broad.mit.edu	37	8	125559309	125559309	+	Silent	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:125559309G>A	uc003yrg.3	+	3	448	c.363G>A	c.(361-363)AAG>AAA	p.K121K	NDUFB9_uc011lim.1_Silent_p.K121K	NM_005005	NP_004996	Q9Y6M9	NDUB9_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	121					mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|skin(1)	2	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)		NADH(DB00157)	ACTTTGCCAAGAGAGAACAGT	0.453			NA											13	462					0	0	0.001855	0	0
ASAP1	50807	broad.mit.edu	37	8	131226829	131226829	+	Silent	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:131226829C>T	uc003yta.1	-	4	406	c.378G>A	c.(376-378)AAG>AAA	p.K126K	ASAP1_uc011liw.1_Silent_p.K119K	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	126					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TGGACAGTTCCTTTGTAAGAG	0.363			NA											16	198					0	0	0.006122	0	0
FAM135B	51059	broad.mit.edu	37	8	139163899	139163899	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:139163899G>A	uc003yuy.2	-	13	2990	c.2819C>T	c.(2818-2820)ACG>ATG	p.T940M	FAM135B_uc003yux.2_Missense_Mutation_p.T841M|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.T502M|FAM135B_uc003yvb.2_Missense_Mutation_p.T502M	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	940										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGCAGCTGACGTACAGCTCAA	0.478			NA								HNSCC(54;0.14)			19	308					0	0	0.007413	0	0
JRK	8629	broad.mit.edu	37	8	143740275	143740275	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:143740275C>G	uc003ywo.2	-	4	2177	c.1663G>C	c.(1663-1665)GAG>CAG	p.E555Q	JRK_uc003ywp.2_3'UTR	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				CATTATGTCTCTGTAGAGGCC	0.532			NA											4	90					0	0	0.009096	0	0
C8orf73	642475	broad.mit.edu	37	8	144654722	144654722	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:144654722C>G	uc010mff.2	-	1	207	c.163G>C	c.(163-165)GAG>CAG	p.E55Q	C8orf73_uc010mfg.1_Missense_Mutation_p.E55Q	NM_001100878	NP_001094348	A6NGR9	CH073_HUMAN	hypothetical protein LOC642475	55							binding			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTCTGTGGCTCAGCCTCAGGT	0.682			NA											5	54					0	0	0.000602	0	0
TLE1	7088	broad.mit.edu	37	9	84267154	84267154	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr9:84267154A>T	uc004aly.2	-	6	788	c.347T>A	c.(346-348)ATG>AAG	p.M116K	TLE1_uc004alz.2_Missense_Mutation_p.M116K|TLE1_uc011lsr.1_Missense_Mutation_p.M116K|TLE1_uc004ama.1_Missense_Mutation_p.M116K|TLE1_uc011lss.1_Missense_Mutation_p.M116K|TLE1_uc004amb.2_Missense_Mutation_p.M116K	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	116	Gln-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						CAATTCTGCCATGGTCACCTG	0.453	NSCLC(155;1437 1995 30668 39354 45875)|Melanoma(16;266 781 14000 47728 51870)		NA											43	99					0	0	0.01441	0	0
TMEFF1	8577	broad.mit.edu	37	9	103204575	103204575	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr9:103204575C>T	uc004bay.1	+	1	388	c.355C>T	c.(355-357)CTC>TTC	p.L119F	C9orf30_uc004baw.2_Missense_Mutation_p.L119F|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				GCCGGAGCAGCTCTACTTCCT	0.612			NA											6	51					0	0	0.001168	0	0
ARSD	414	broad.mit.edu	37	X	2835948	2835948	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:2835948A>T	uc004cqy.2	-	5	836	c.760T>A	c.(760-762)TGG>AGG	p.W254R	ARSD_uc004cqz.1_Intron|ARSD_uc004cra.1_Missense_Mutation_p.W254R	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	254						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATACAGTTCCAGCGTCGCACA	0.522			NA											5	25					0	0	0.001168	0	0
PNPLA4	8228	broad.mit.edu	37	X	7870079	7870079	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:7870079T>A	uc011mhq.1	-	6	743	c.581A>T	c.(580-582)GAC>GTC	p.D194V	PNPLA4_uc011mhr.1_Missense_Mutation_p.D194V|PNPLA4_uc011mhs.1_Missense_Mutation_p.D107V	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	194					lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				CTGCCCTTTGTCCTGCGGGGA	0.498			NA											19	57					0	0	0.010504	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254547	30254547	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:30254547A>T	uc004dca.1	+	5	1243	c.506A>T	c.(505-507)AAG>ATG	p.K169M		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	169	MAGE.										0						GTTGATTTAAAGAAAGTTGAT	0.413			NA											5	68					0	0	0.000602	0	0
DMD	1756	broad.mit.edu	37	X	31496492	31496492	+	Splice_Site	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:31496492C>T	uc004dda.1	-	59	8913	c.8669_splice	c.e59-1	p.E2890_splice	DMD_uc004dcq.1_Splice_Site_p.E161_splice|DMD_uc004dcr.1_Splice_Site_p.E430_splice|DMD_uc004dcs.1_Splice_Site_p.E430_splice|DMD_uc004dct.1_Splice_Site_p.E430_splice|DMD_uc004dcu.1_Splice_Site_p.E430_splice|DMD_uc004dcv.1_Splice_Site_p.E430_splice|DMD_uc004dcw.2_Splice_Site_p.E1546_splice|DMD_uc004dcx.2_Splice_Site_p.E1549_splice|DMD_uc004dcz.2_Splice_Site_p.E2767_splice|DMD_uc004dcy.1_Splice_Site_p.E2886_splice|DMD_uc004ddb.1_Splice_Site_p.E2882_splice	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGAGGCAGCTCTAAATTGGCA	0.433			NA											10	68					0	0	0.008291	0	0
FAM47A	158724	broad.mit.edu	37	X	34149740	34149740	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:34149740G>A	uc004ddg.2	-	1	689	c.656C>T	c.(655-657)CCG>CTG	p.P219L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	219	Pro-rich.									ovary(4)|central_nervous_system(1)	5						ACTGGACACCGGAGTCTTGGG	0.657			NA											17	82					0	0	0.008871	0	0
ZNF673	55634	broad.mit.edu	37	X	46322632	46322632	+	Splice_Site	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:46322632G>T	uc004dgn.3	+	5	442	c.143_splice	c.e5-1	p.G48_splice	ZNF673_uc004dgp.3_Splice_Site_p.G48_splice|ZNF673_uc010nhl.2_Splice_Site_p.G48_splice|ZNF673_uc004dgm.3_Splice_Site_p.G48_splice	NM_001129898	NP_001123370	Q5JUW0	ZN673_HUMAN	zinc finger family member 673 isoform 1						regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0						CCCCCGAACAGGGTATCTAGT	0.557			NA											19	41					8.34094e-07	9.46809e-07	0.008871	1	0
ZC3H12B	340554	broad.mit.edu	37	X	64721936	64721936	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:64721936T>C	uc010nko.2	+	5	1334	c.1325T>C	c.(1324-1326)ATT>ACT	p.I442T		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	442							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						TGGCTGTCCATTGCCCGTAAG	0.567			NA											8	70					0	0	0.004482	0	0
FOXO4	4303	broad.mit.edu	37	X	70320855	70320855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:70320855C>T	uc004dys.1	+	2	1128	c.775C>T	c.(775-777)CGA>TGA	p.R259*	FOXO4_uc010nkz.2_Nonsense_Mutation_p.R259*|FOXO4_uc004dyt.1_Nonsense_Mutation_p.R204*	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	259					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)					CTTCCGTCCACGAAGCAGTTC	0.582			NA									OREG0019856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	22					0	0	0.001984	0	0
KLHL4	56062	broad.mit.edu	37	X	86888891	86888891	+	Silent	SNP	T	T	A			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:86888891T>A	uc004efb.2	+	8	1874	c.1692T>A	c.(1690-1692)GGT>GGA	p.G564G	KLHL4_uc004efa.2_Silent_p.G564G	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	564	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCACAGTTGGTGTTGTTGCAT	0.418			NA											4	43					0	0	0.001984	0	0
RGAG1	57529	broad.mit.edu	37	X	109694853	109694853	+	Silent	SNP	A	A	G			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:109694853A>G	uc004eor.1	+	3	1254	c.1008A>G	c.(1006-1008)TTA>TTG	p.L336L	RGAG1_uc011msr.1_Silent_p.L336L	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	336										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TGTCCACATTACCAAAGCCAG	0.522			NA											32	375					0	0	0.008361	0	0
LRCH2	57631	broad.mit.edu	37	X	114357660	114357660	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:114357660T>C	uc010nqe.2	-	18	1976	c.1945A>G	c.(1945-1947)ATA>GTA	p.I649V	LRCH2_uc004epz.2_Missense_Mutation_p.I632V	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	649	CH.									ovary(1)	1						AGTTGTCGTATTTGCTCTCGC	0.408			NA											4	26					0	0	0.000602	0	0
IGSF1	3547	broad.mit.edu	37	X	130408758	130408758	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:130408758C>T	uc004ewd.2	-	18	3804	c.3566G>A	c.(3565-3567)GGT>GAT	p.G1189D	IGSF1_uc004ewe.3_Missense_Mutation_p.G1183D|IGSF1_uc004ewf.2_Missense_Mutation_p.G1169D	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1189	Extracellular (Potential).|Ig-like C2-type 12.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						AAATTCAACACCTGGCAGGGG	0.502			NA											16	200					0	0	0.004007	0	0
MAP7D3	79649	broad.mit.edu	37	X	135323326	135323326	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:135323326G>T	uc004ezt.2	-	5	619	c.528C>A	c.(526-528)AGC>AGA	p.S176R	MAP7D3_uc004ezs.2_Missense_Mutation_p.S175R|MAP7D3_uc011mwc.1_Missense_Mutation_p.S158R|MAP7D3_uc010nsa.1_Missense_Mutation_p.S175R	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	176						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TACCAGTTTTGCTCTCAGAAT	0.368			NA											4	32					0.00909568	0.00949114	0.009096	1	0
MCF2	4168	broad.mit.edu	37	X	138699760	138699760	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:138699760C>T	uc004fau.2	-	8	1205	c.911G>A	c.(910-912)CGT>CAT	p.R304H	MCF2_uc004fav.2_Missense_Mutation_p.R304H|MCF2_uc011mwl.1_Missense_Mutation_p.R265H|MCF2_uc010nsh.1_Missense_Mutation_p.R304H|MCF2_uc011mwm.1_Missense_Mutation_p.R265H|MCF2_uc011mwn.1_Missense_Mutation_p.R449H|MCF2_uc004faw.2_Missense_Mutation_p.R364H|MCF2_uc011mwo.1_Missense_Mutation_p.R364H	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	304	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					AGAAAGGTAACGTAGCTCATT	0.393			NA											73	117					0	0	0.01441	0	0
FMR1	2332	broad.mit.edu	37	X	147018985	147018985	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chrX:147018985G>C	uc010nst.2	+	11	1180	c.991G>C	c.(991-993)GAA>CAA	p.E331Q	FMR1_uc004fcj.2_Missense_Mutation_p.E329Q|FMR1_uc004fck.3_Missense_Mutation_p.E331Q|FMR1_uc004fcl.3_Missense_Mutation_p.E192Q|FMR1_uc011mxa.1_5'UTR	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	331					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTACCAAGGAAATTATGCC	0.269			NA							Fragile_X_syndrome				4	66					0	0	0.009096	0	0
CBL	867	broad.mit.edu	37	11	119149277	119149288	+	In_Frame_Del	DEL	ATCGTGGTAGAT	ATCGTGGTAGAT	-	rs148368481		TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	ATCGTGGTAGAT	ATCGTGGTAGAT	-	-	ATCGTGGTAGAT	ATCGTGGTAGAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:119149277_119149288delATCGTGGTAGAT	uc001pwe.2	+	9	1423_1434	c.1285_1296delATCGTGGTAGAT	c.(1285-1296)ATCGTGGTAGATdel	p.IVVD429del		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	429_432	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.G397_I429del(1)|p.I429_F434del(1)|p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TACTGAACCCATCGTGGTAGATCCGTTTGATC	0.462			NA							CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				22	68	---	---	---	---	NA	NA	NA	NA	NA
SNX19	399979	broad.mit.edu	37	11	130784287	130784287	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr11:130784287delG	uc001qgk.3	-	1	2096	c.1548delC	c.(1546-1548)TTCfs	p.F516fs	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Frame_Shift_Del_p.F516fs|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	516					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		GCTCAAAGCTGAAGGTGGCTG	0.537			NA											8	74	---	---	---	---	NA	NA	NA	NA	NA
BTG1	694	broad.mit.edu	37	12	92538035	92538041	+	Frame_Shift_Del	DEL	AGGACAC	AGGACAC	-			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	AGGACAC	AGGACAC	-	-	AGGACAC	AGGACAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr12:92538035_92538041delAGGACAC	uc001tby.3	-	2	693_699	c.331_337delGTGTCCT	c.(331-339)GTGTCCTACfs	p.V111fs	BTG1_uc001tbv.1_5'Flank|BTG1_uc001tbw.1_5'Flank|BTG1_uc001tbx.1_5'Flank|BTG1_uc009zss.1_5'Flank|uc001tca.2_5'Flank	NM_001731	NP_001722	P62324	BTG1_HUMAN	B-cell translocation protein 1	111_113					cell migration|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|regulation of apoptosis|regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|transcription cofactor activity				0		Acute lymphoblastic leukemia(6;3.02e-13)|all_hematologic(6;4.32e-09)				CCAATTCTGTAGGACACTTCATAGGGG	0.531			NA	T	MYC	BCLL						OREG0022024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	63	---	---	---	---	NA	NA	NA	NA	NA
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574			NA											9	240	---	---	---	---	NA	NA	NA	NA	NA
GRLF1	2909	broad.mit.edu	37	19	47503733	47503735	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	CAG	CAG	-	-	CAG	CAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr19:47503733_47503735delCAG	uc010ekv.2	+	6	4288_4290	c.4288_4290delCAG	c.(4288-4290)CAGdel	p.Q1431del		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1431	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		ACTCTTTATCCAGCAGTGCCCCT	0.596			NA											42	119	---	---	---	---	NA	NA	NA	NA	NA
MED15	51586	broad.mit.edu	37	22	20920814	20920816	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	CAG	CAG	-	-	CAG	CAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr22:20920814_20920816delCAG	uc002zsp.2	+	7	831_833	c.751_753delCAG	c.(751-753)CAGdel	p.Q262del	MED15_uc002zso.2_In_Frame_Del_p.Q191del|MED15_uc002zsq.2_In_Frame_Del_p.Q262del|MED15_uc010gso.2_In_Frame_Del_p.Q262del|MED15_uc002zsr.2_In_Frame_Del_p.Q236del|MED15_uc011ahs.1_In_Frame_Del_p.Q236del|MED15_uc002zss.2_In_Frame_Del_p.Q181del|MED15_uc011ahu.1_5'UTR	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	262	Poly-Gln.		Missing.	Missing (in Ref. 3; BAB85034).	regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			acaacagcaacagcagcagcagc	0.315			NA											7	55	---	---	---	---	NA	NA	NA	NA	NA
DZIP3	9666	broad.mit.edu	37	3	108366847	108366847	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr3:108366847delA	uc003dxd.2	+	16	2272	c.1850delA	c.(1849-1851)GAGfs	p.E617fs	DZIP3_uc003dxf.1_Frame_Shift_Del_p.E617fs|DZIP3_uc011bhm.1_Frame_Shift_Del_p.E68fs|DZIP3_uc003dxe.1_Frame_Shift_Del_p.E617fs|DZIP3_uc003dxg.1_Frame_Shift_Del_p.E340fs	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	617					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTCTCATGGAGTACAATATA	0.333			NA											12	68	---	---	---	---	NA	NA	NA	NA	NA
SULF1	23213	broad.mit.edu	37	8	70514026	70514026	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7153-01A-11D-2036-08	TCGA-78-7153-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	03e4e53c-0d21-4492-af79-b70a90d32dff	7be9ef7a-2d28-474f-8c51-c17dabed684c	g.chr8:70514026delT	uc010lza.1	+	10	1740	c.1023delT	c.(1021-1023)CCTfs	p.P341fs	SULF1_uc003xyd.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xye.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xyf.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xyg.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	341					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTCGTGTGCCTTTTTTTATTC	0.408			NA											8	1371	---	---	---	---	NA	NA	NA	NA	NA
