Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CORT	1325	broad.mit.edu	37	1	10510148	10510148	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:10510148C>T	uc001ari.2	+	1	178	c.18C>T	c.(16-18)AAC>AAT	p.N6N	APITD1_uc001arf.2_Intron|APITD1_uc001arg.2_Intron	NM_001302	NP_001293	O00230	CORT_HUMAN	cortistatin preproprotein	Error:Variant_position_missing_in_O00230_after_alignment					inhibition of adenylate cyclase activity by G-protein signaling pathway|synaptic transmission	extracellular region|soluble fraction	G-protein-coupled receptor binding|neuropeptide hormone activity				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0487)		GACACAAAAACAGCTGGAGAT	0.517			NA											33	112					0	0	0.009535	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919947	12919947	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:12919947G>A	uc001aum.1	+	3	774	c.687G>A	c.(685-687)AAG>AAA	p.K229K		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	229											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTTACCTGAAGGAGATGAAGA	0.403			NA											15	96					0	0	0.004007	0	0
SPEN	23013	broad.mit.edu	37	1	16258058	16258058	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:16258058G>A	uc001axk.1	+	11	5527	c.5323G>A	c.(5323-5325)GAA>AAA	p.E1775K	SPEN_uc010obp.1_Missense_Mutation_p.E1734K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1775					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCCAAAGGCCGAAAAGCCAGA	0.532			NA											21	90					0	0	0.008871	0	0
EIF4G3	8672	broad.mit.edu	37	1	21276584	21276584	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:21276584G>A	uc001bec.2	-	8	823	c.567C>T	c.(565-567)CCC>CCT	p.P189P	EIF4G3_uc010odi.1_Intron|EIF4G3_uc010odj.1_Silent_p.P188P|EIF4G3_uc009vpz.2_Silent_p.P189P|EIF4G3_uc001bed.2_Silent_p.P189P|EIF4G3_uc001bef.2_Silent_p.P188P|EIF4G3_uc001bee.2_Silent_p.P195P|EIF4G3_uc001beg.2_Silent_p.P188P|EIF4G3_uc010odk.1_Silent_p.P189P|EIF4G3_uc001beh.2_Silent_p.P200P	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	189					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GGCTGTGCTCGGGGACCTGGC	0.527			NA											10	31					0	0	0.013537	0	0
RHCE	6006	broad.mit.edu	37	1	25729191	25729191	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:25729191C>A	uc001bkf.2	-	3	468	c.382G>T	c.(382-384)GGT>TGT	p.G128C	RHCE_uc001bkg.2_Missense_Mutation_p.G128C|RHCE_uc001bkh.2_Missense_Mutation_p.G128C|RHCE_uc001bki.2_Missense_Mutation_p.G128C|RHCE_uc001bkj.2_Missense_Mutation_p.G112C	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	128	Helical; (Potential).					integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AAGACAGCACCCGCTGAGATC	0.537			NA											38	53					1.836e-18	2.31916e-18	0.003755	1	0
ADPRHL2	54936	broad.mit.edu	37	1	36557266	36557266	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:36557266G>T	uc001bzt.2	+	3	409	c.356G>T	c.(355-357)GGA>GTA	p.G119V	ADPRHL2_uc001bzu.2_5'UTR	NM_017825	NP_060295	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	119						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			pancreas(1)	1		Myeloproliferative disorder(586;0.0393)				TATGGTGCTGGAGTAGTCACT	0.507			NA											26	49					5.45727e-16	6.80387e-16	0.008361	1	0
POU3F1	5453	broad.mit.edu	37	1	38511276	38511276	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:38511276C>T	uc001ccp.1	-	1	1175	c.1140G>A	c.(1138-1140)AAG>AAA	p.K380K		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	380	Homeobox.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GCACCACCTCCTTCTCCAGCT	0.672			NA											4	12					0	0	0.009096	0	0
TOE1	114034	broad.mit.edu	37	1	45808899	45808899	+	Missense_Mutation	SNP	C	C	T	rs145913038		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:45808899C>T	uc009vxq.2	+	8	1641	c.1058C>T	c.(1057-1059)CCG>CTG	p.P353L	MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Missense_Mutation_p.P273L|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	353						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					TTGAACCTACCGGGGACACAG	0.557			NA											22	94					0	0	0.012319	0	0
OSBPL9	114883	broad.mit.edu	37	1	52249623	52249623	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:52249623T>C	uc001cst.2	+	18	1569	c.1550T>C	c.(1549-1551)ATA>ACA	p.I517T	OSBPL9_uc001css.2_Missense_Mutation_p.I522T|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.I518T|OSBPL9_uc001csu.2_Missense_Mutation_p.I527T|OSBPL9_uc001csv.2_Missense_Mutation_p.I352T|OSBPL9_uc001csw.2_Missense_Mutation_p.I504T|OSBPL9_uc001csy.2_Missense_Mutation_p.I339T|OSBPL9_uc001csz.2_Missense_Mutation_p.I339T|OSBPL9_uc001cta.2_Missense_Mutation_p.I407T|OSBPL9_uc001ctb.2_Missense_Mutation_p.I302T	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	517					lipid transport		lipid binding			central_nervous_system(1)	1						AACAAGAAGATACAATTCAAT	0.378			NA											7	27					0	0	0.00308	0	0
GLIS1	148979	broad.mit.edu	37	1	53980329	53980329	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:53980329G>T	uc001cvr.1	-	7	1894	c.1327C>A	c.(1327-1329)CCT>ACT	p.P443T		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	443					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATGGGCAGAGGGGACAGATGG	0.657			NA											7	46					0.00198382	0.00214588	0.001984	1	0
LEPR	3953	broad.mit.edu	37	1	66083657	66083657	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:66083657G>T	uc001dci.2	+	16	2425	c.2223G>T	c.(2221-2223)GTG>GTT	p.V741V	LEPR_uc001dcg.2_Silent_p.V741V|LEPR_uc001dch.2_Silent_p.V741V|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.V741V|LEPR_uc001dck.2_Silent_p.V741V	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	741	Extracellular (Potential).|Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TAAATATCGTGCAGTCACTCA	0.313			NA											16	27					6.72482e-11	8.01967e-11	0.003163	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74540470	74540470	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:74540470A>G	uc001dfy.3	-	6	1064	c.872T>C	c.(871-873)ATA>ACA	p.I291T	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	291										ovary(2)	2						AGGATAATATATATTCTGTGA	0.164			NA											3	9					0	0	0.009096	0	0
LPHN2	23266	broad.mit.edu	37	1	82417743	82417743	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:82417743G>T	uc001dit.3	+	9	1880	c.1699G>T	c.(1699-1701)GAG>TAG	p.E567*	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Nonsense_Mutation_p.E567*|LPHN2_uc001div.2_Nonsense_Mutation_p.E567*|LPHN2_uc009wcd.2_Nonsense_Mutation_p.E567*|LPHN2_uc001diw.2_Nonsense_Mutation_p.E138*	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	567	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GAGATTGATGGAGCAGTTGGT	0.458			NA											15	12					1.3612e-06	1.54189e-06	0.003163	1	0
LPPR4	9890	broad.mit.edu	37	1	99771294	99771294	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:99771294C>A	uc001dse.2	+	7	1126	c.1020C>A	c.(1018-1020)CAC>CAA	p.H340Q	LPPR4_uc010oue.1_Missense_Mutation_p.H282Q	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	340							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TGTTTCAGCACAGAGACGCCC	0.448			NA											36	52					1.36239e-07	1.57104e-07	0.003271	1	0
LPPR4	9890	broad.mit.edu	37	1	99771339	99771339	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:99771339C>A	uc001dse.2	+	7	1171	c.1065C>A	c.(1063-1065)AAC>AAA	p.N355K	LPPR4_uc010oue.1_Missense_Mutation_p.N297K	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	355							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AAGATCCCAACCGACTTTTAT	0.478			NA											16	81					1.5739e-10	1.87113e-10	0.004007	1	0
LPPR4	9890	broad.mit.edu	37	1	99772332	99772332	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:99772332G>C	uc001dse.2	+	7	2164	c.2058G>C	c.(2056-2058)AAG>AAC	p.K686N	LPPR4_uc010oue.1_Missense_Mutation_p.K628N	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	686							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GAGATCGCAAGAGAAGCAACA	0.512			NA											4	21					0	0	0.009096	0	0
BCL9	607	broad.mit.edu	37	1	147091285	147091285	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:147091285C>A	uc001epq.2	+	8	2064	c.1324C>A	c.(1324-1326)CCA>ACA	p.P442T	BCL9_uc010ozr.1_Missense_Mutation_p.P368T	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	442	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					ACCCTTTTCTCCAGATGAAAT	0.542			NA	T	IGH@|IGL@	B-ALL								16	38					3.45872e-05	3.8497e-05	0.004007	1	0
KIRREL	55243	broad.mit.edu	37	1	158064493	158064493	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:158064493A>G	uc001frn.3	+	15	2261	c.1857A>G	c.(1855-1857)GCA>GCG	p.A619A	KIRREL_uc010pib.1_Silent_p.A519A|KIRREL_uc009wsq.2_Silent_p.A455A|KIRREL_uc001fro.3_Silent_p.A433A|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	619	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CTTCCAGGGCAGTGCTCTATG	0.637			NA											7	49					0	0	0.001984	0	0
OR6N2	81442	broad.mit.edu	37	1	158747203	158747203	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:158747203C>T	uc010pir.1	-	1	223	c.223G>A	c.(223-225)GCT>ACT	p.A75T		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					ATAGTGGTAGCTGTATACCAC	0.443			NA											19	104					0	0	0.007413	0	0
CRP	1401	broad.mit.edu	37	1	159683534	159683534	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:159683534G>A	uc001ftw.2	-	2	560	c.456C>T	c.(454-456)ATC>ATT	p.I152I	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	152	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CCTGCCCCAAGATGATGCTTG	0.547			NA											122	262					0	0	0.01441	0	0
TAGLN2	8407	broad.mit.edu	37	1	159889539	159889539	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:159889539C>G	uc001fum.1	-	2	317	c.267G>C	c.(265-267)CAG>CAC	p.Q89H	CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Missense_Mutation_p.Q89H|TAGLN2_uc001fuo.1_Missense_Mutation_p.Q89H|TAGLN2_uc010piy.1_3'UTR	NM_003564	NP_003555	P37802	TAGL2_HUMAN	transgelin 2	89	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTGCTCCATCTGCTTGAAGG	0.552			NA											66	138					0	0	0.01441	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186934691	186934691	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:186934691C>A	uc001gsc.2	+	15	1935	c.1730C>A	c.(1729-1731)TCT>TAT	p.S577Y	PLA2G4A_uc010pos.1_Missense_Mutation_p.S517Y	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	577	PLA2c.			S->A: 7-fold reduced phospholipase and lysophosphatase activities. 100-fold reduced phospholipase and lysophosphatase activities; when associated with A-195.	phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TTTGACTTTTCTGCAAGGCCA	0.433			NA											6	84					5.9392e-07	6.76752e-07	0.001168	1	0
DISP1	84976	broad.mit.edu	37	1	223176456	223176456	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:223176456G>A	uc001hnu.1	+	8	1864	c.1717G>A	c.(1717-1719)GAT>AAT	p.D573N		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	573	SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TGGAGCAGATGATGCTTTTGT	0.403			NA											32	60					0	0	0.008361	0	0
OBSCN	84033	broad.mit.edu	37	1	228522247	228522247	+	Splice_Site	SNP	T	T	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:228522247T>G	uc009xez.1	+	60	16131	c.16087_splice	c.e60+2	p.D5363_splice	OBSCN_uc001hsn.2_Splice_Site_p.D5363_splice|OBSCN_uc001hsr.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGCATCAGGTGAGGCAGCCC	0.662			NA											2	3					0	0	0.004672	0	0
C1orf124	83932	broad.mit.edu	37	1	231487114	231487114	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:231487114C>T	uc001hur.2	+	4	963	c.515C>T	c.(514-516)CCG>CTG	p.P172L	C1orf124_uc001hus.2_Missense_Mutation_p.P172L|C1orf124_uc001hut.2_Missense_Mutation_p.P129L	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	172					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TGCAATGGGCCGTGCCAGCAC	0.498	Esophageal Squamous(43;65 937 18756 45127 47168)		NA											13	50					0	0	0.001855	0	0
RBM34	23029	broad.mit.edu	37	1	235318412	235318412	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:235318412C>T	uc001hwn.2	-	4	411	c.381G>A	c.(379-381)GCG>GCA	p.A127A	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Silent_p.A127A	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	127						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			AATCAGCACTCGCTAGAGCGC	0.393			NA											22	33					0	0	0.00333	0	0
FMN2	56776	broad.mit.edu	37	1	240601508	240601508	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:240601508G>A	uc010pyd.1	+	16	5283	c.5058G>A	c.(5056-5058)GAG>GAA	p.E1686E	FMN2_uc010pye.1_Silent_p.E1690E|FMN2_uc010pyg.1_Silent_p.E282E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1686	Potential.|FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTCTACAAGAGAGGTAGGTAT	0.388			NA											9	55					0	0	0.004482	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242162301	242162301	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:242162301G>C	uc001hzk.2	-	1	85	c.10C>G	c.(10-12)CCA>GCA	p.P4A		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	4					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ATTTTCTGTGGAGGCGGCATT	0.468			NA									OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	56					0	0	0.00278	0	0
OR2W3	343171	broad.mit.edu	37	1	248059253	248059253	+	Missense_Mutation	SNP	G	G	T	rs141229039	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:248059253G>T	uc001idp.1	+	3	634	c.365G>T	c.(364-366)CGG>CTG	p.R122L	OR2W3_uc010pzb.1_Missense_Mutation_p.R122L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCTATGACCGGTGTGTGGCT	0.602			NA											21	48					6.33239e-15	7.84399e-15	0.010504	1	0
OR2G6	391211	broad.mit.edu	37	1	248685664	248685664	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:248685664G>A	uc001ien.1	+	1	717	c.717G>A	c.(715-717)GGG>GGA	p.G239G		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGCCTTTGGGACCTGTTCGT	0.458			NA											22	64					0	0	0.010504	0	0
TAF3	83860	broad.mit.edu	37	10	8006790	8006790	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:8006790C>T	uc010qbd.1	+	3	1317	c.1317C>T	c.(1315-1317)TCC>TCT	p.S439S		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	439					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						CTTCCACTTCCGCGAACAATT	0.468			NA											25	98					0	0	0.00333	0	0
SUV39H2	79723	broad.mit.edu	37	10	14939122	14939122	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:14939122G>A	uc001inh.2	+	2	331	c.275G>A	c.(274-276)GGA>GAA	p.G92E	SUV39H2_uc001ing.2_Intron|SUV39H2_uc001ini.2_Missense_Mutation_p.G92E|SUV39H2_uc001inj.2_Missense_Mutation_p.G92E	NM_024670	NP_078946	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2	152					cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|ovary(1)	3						AATCATAAAGGAATGATATTT	0.383			NA											12	35					0	0	0.010729	0	0
PTER	9317	broad.mit.edu	37	10	16547037	16547037	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:16547037A>G	uc001iog.1	+	5	924	c.717A>G	c.(715-717)AAA>AAG	p.K239K	PTER_uc001ioh.1_Silent_p.K239K|PTER_uc001ioi.1_Silent_p.K239K|PTER_uc009xjp.1_Intron	NM_030664	NP_109589	Q96BW5	PTER_HUMAN	phosphotriesterase related	239					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			ovary(2)	2						TTGATAAGAAAGAGCTCTTGG	0.393	Ovarian(2;46 150 15648 38137 47908)		NA											25	71					0	0	0.004656	0	0
MLLT10	8028	broad.mit.edu	37	10	22016856	22016856	+	Missense_Mutation	SNP	C	C	G	rs138169869		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:22016856C>G	uc001iqs.2	+	17	2458	c.2110C>G	c.(2110-2112)CGA>GGA	p.R704G	MLLT10_uc001iqt.2_Missense_Mutation_p.R688G|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.R688G|MLLT10_uc001ira.2_Missense_Mutation_p.R145G|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	704					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						TCTCTCGCCACGGTAAGCGCT	0.423			NA	T	MLL|PICALM|CDK6	AL								7	14					0	0	0.00308	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508673	37508673	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:37508673G>A	uc001iza.1	+	34	3964	c.3865G>A	c.(3865-3867)GAC>AAC	p.D1289N		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1345						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TAAGAAAGCTGACAACAAAAG	0.318			NA											4	22					0	0	0.009096	0	0
ANUBL1	93550	broad.mit.edu	37	10	46111945	46111945	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:46111945C>A	uc001jcp.3	-	10	2365	c.2123G>T	c.(2122-2124)GGG>GTG	p.G708V	ANUBL1_uc001jcl.3_Missense_Mutation_p.G228V|ANUBL1_uc001jcm.3_Missense_Mutation_p.G708V|ANUBL1_uc009xmu.2_Missense_Mutation_p.G634V|ANUBL1_uc001jcn.3_Missense_Mutation_p.G634V|ANUBL1_uc001jco.3_3'UTR	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	708	AN1-type.						zinc ion binding				0						GTATCTCCTCCCTGCACTCTT	0.423			NA											35	22					1.26612e-14	1.56331e-14	0.003271	1	0
PCDH15	65217	broad.mit.edu	37	10	55566757	55566757	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:55566757T>C	uc010qhq.1	-	36	5026	c.4631A>G	c.(4630-4632)AAT>AGT	p.N1544S	PCDH15_uc010qhr.1_Missense_Mutation_p.N1539S	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AATATATATATTGCCGTTGAT	0.483			NA								HNSCC(58;0.16)			9	36					0	0	0.006214	0	0
ANK3	288	broad.mit.edu	37	10	61844939	61844939	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:61844939G>A	uc001jky.2	-	31	4013	c.3821C>T	c.(3820-3822)TCC>TTC	p.S1274F	ANK3_uc001jkw.2_Missense_Mutation_p.S408F|ANK3_uc009xpa.2_Missense_Mutation_p.S408F|ANK3_uc001jkx.2_Missense_Mutation_p.S452F|ANK3_uc010qih.1_Missense_Mutation_p.S1275F|ANK3_uc001jkz.3_Missense_Mutation_p.S1268F|ANK3_uc001jla.1_Missense_Mutation_p.S340F|ANK3_uc001jlb.1_Missense_Mutation_p.S792F|ANK3_uc001jkv.2_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1274					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTTGTAAAGGAGACACAATC	0.388			NA											20	4					0	0	0.012319	0	0
MYPN	84665	broad.mit.edu	37	10	69959140	69959140	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:69959140C>T	uc001jnm.3	+	18	3486	c.3301C>T	c.(3301-3303)CCC>TCC	p.P1101S	MYPN_uc001jnn.3_Missense_Mutation_p.P826S|MYPN_uc001jno.3_Missense_Mutation_p.P1101S|MYPN_uc009xpt.2_Missense_Mutation_p.P1101S|MYPN_uc010qit.1_Missense_Mutation_p.P807S|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1101	Ig-like 4.|Interaction with ACTN.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TGGTTTACCGCCCCCGGAGCT	0.507			NA											10	20					0	0	0.008291	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122032	73122032	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:73122032C>T	uc001jrr.3	+	6	1152	c.1095C>T	c.(1093-1095)CTC>CTT	p.L365L	SLC29A3_uc001jrs.3_3'UTR|SLC29A3_uc010qjq.1_Silent_p.L219L|SLC29A3_uc001jrt.3_Silent_p.L159L|SLC29A3_uc001jru.3_Silent_p.L177L	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	365	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						GCCGGCAGCTCACCGCCTGGA	0.597	Esophageal Squamous(200;1319 2142 18949 31248 39672)		NA											32	146					0	0	0.008361	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534866	96534866	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:96534866A>G	uc010qnz.1	+	2	220	c.220A>G	c.(220-222)ATG>GTG	p.M74V	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Missense_Mutation_p.M52V	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	74					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CCTGGAACGCATGGTGGTGCT	0.453			NA											52	28					0	0	0.01441	0	0
CHUK	1147	broad.mit.edu	37	10	101960516	101960516	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:101960516C>A	uc001kqp.2	-	15	1646	c.1591G>T	c.(1591-1593)GAG>TAG	p.E531*		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	531					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ATCTGATCCTCCAGGTATCCA	0.398	Ovarian(159;52 1904 10536 35305 37148)		NA											7	51					1.26484e-09	1.49446e-09	0.00308	1	0
PAX2	5076	broad.mit.edu	37	10	102546746	102546746	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:102546746G>C	uc001krk.3	+	6	1213	c.663G>C	c.(661-663)TTG>TTC	p.L221F	PAX2_uc001krl.3_Intron|PAX2_uc001krm.3_Missense_Mutation_p.L221F|PAX2_uc001kro.3_Intron|PAX2_uc001krn.3_Intron|PAX2_uc010qps.1_Intron|PAX2_uc001krp.1_Intron	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	221					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		GTGGAGGTTTGCATCTGGTCT	0.512			NA									OREG0002760	type=REGULATORY REGION|Gene=PAX2(intragenic)|Dataset=Vista Enhancers|EvidenceSubtype=In-vivo LacZ Expression Assay	16	17					0	0	0.004007	0	0
C10orf118	55088	broad.mit.edu	37	10	115895981	115895981	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:115895981C>T	uc001lbb.1	-	8	2003	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K	C10orf118_uc009xyd.1_Missense_Mutation_p.E49K|C10orf118_uc001lbc.1_Missense_Mutation_p.E451K|C10orf118_uc009xye.1_RNA	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	451	Potential.									ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		GCATCAAGCTCATTTGATTTA	0.264			NA											5	40					0	0	0.000602	0	0
OR52B4	143496	broad.mit.edu	37	11	4388806	4388806	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:4388806G>C	uc010qye.1	-	1	720	c.720C>G	c.(718-720)CTC>CTG	p.L240L		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAAATGTGTTGAGAGCTTTGT	0.453			NA											13	29					0	0	0.013537	0	0
OR52R1	119695	broad.mit.edu	37	11	4825663	4825663	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:4825663T>A	uc010qym.1	-	1	185	c.185A>T	c.(184-186)TAT>TTT	p.Y62F		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	Error:Variant_position_missing_in_Q8NGF1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGCAGATGATAACAATCAAA	0.403			NA											9	26					0	0	0.006214	0	0
OR51B5	282763	broad.mit.edu	37	11	5364617	5364617	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:5364617G>A	uc001map.1	-	1	138	c.138C>T	c.(136-138)CTC>CTT	p.L46L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Silent_p.L46L	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	46	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCCTTAATGAGAAGAAGGA	0.493			NA											15	22					0	0	0.003163	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443687	5443687	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:5443687T>G	uc010qzd.1	+	1	257	c.257T>G	c.(256-258)CTT>CGT	p.L86R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCATGCAGCTTCTCTGGTTC	0.522			NA											14	62					0	0	0.00245	0	0
DNHD1	144132	broad.mit.edu	37	11	6523987	6523987	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:6523987C>G	uc001mdw.3	+	4	1315	c.751C>G	c.(751-753)CAG>GAG	p.Q251E	DNHD1_uc001mdp.2_Missense_Mutation_p.Q251E	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	251					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ACACAGGTCTCAGCTTGACTA	0.493			NA											13	15					0	0	0.013537	0	0
RNF141	50862	broad.mit.edu	37	11	10555597	10555597	+	Missense_Mutation	SNP	C	C	G	rs149870408		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:10555597C>G	uc001mis.1	-	2	262	c.109G>C	c.(109-111)GAA>CAA	p.E37Q	RNF141_uc009yga.1_RNA|RNF141_uc001mit.1_Missense_Mutation_p.E37Q	NM_016422	NP_057506	Q8WVD5	RN141_HUMAN	ring finger protein 141	37							zinc ion binding				0				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		CCAAGAAATTCTTCATAAGTT	0.393	Ovarian(8;377 410 25844 26058 41491)		NA											18	32					0	0	0.007413	0	0
MADD	8567	broad.mit.edu	37	11	47315475	47315475	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:47315475G>C	uc001ner.1	+	22	3648	c.3457G>C	c.(3457-3459)GAG>CAG	p.E1153Q	MADD_uc001neq.2_Missense_Mutation_p.E1115Q|MADD_uc001nev.1_Missense_Mutation_p.E1072Q|MADD_uc001nes.1_Missense_Mutation_p.E1092Q|MADD_uc001net.1_Missense_Mutation_p.E1135Q|MADD_uc009yln.1_Missense_Mutation_p.E1072Q|MADD_uc001neu.1_Missense_Mutation_p.E1072Q|MADD_uc001nex.2_Missense_Mutation_p.E1153Q|MADD_uc001nez.2_Missense_Mutation_p.E1072Q|MADD_uc001new.2_Missense_Mutation_p.E1115Q|MADD_uc009ylo.2_Missense_Mutation_p.E71Q	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1153					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		TGGTGAGACAGAGGAGAAAAA	0.478			NA											16	31					0	0	0.008871	0	0
OR4X2	119764	broad.mit.edu	37	11	48267148	48267148	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:48267148G>A	uc001ngs.1	+	1	493	c.493G>A	c.(493-495)GTG>ATG	p.V165M		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGCCCCAATGTGATCAATCA	0.493			NA											78	191					0	0	0.01441	0	0
OR4P4	81300	broad.mit.edu	37	11	55406751	55406751	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:55406751G>A	uc010rij.1	+	1	918	c.918G>A	c.(916-918)CTG>CTA	p.L306L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAATACTCCTGAAAAGAAATC	0.398			NA											8	24					0	0	0.00308	0	0
OR4S2	219431	broad.mit.edu	37	11	55418793	55418793	+	Silent	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:55418793A>T	uc001nhs.1	+	1	414	c.414A>T	c.(412-414)ACA>ACT	p.T138T		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	138	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				ACCGGGAGACATGCAATAAAA	0.438			NA											96	59					0	0	0.01441	0	0
OR5M10	390167	broad.mit.edu	37	11	56344765	56344765	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:56344765C>A	uc001niz.1	-	1	433	c.433G>T	c.(433-435)GTC>TTC	p.V145F		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCACAGTGACCAGAGAGATG	0.438			NA											58	32					5.86059e-21	7.45187e-21	0.01441	1	0
MS4A3	932	broad.mit.edu	37	11	59837144	59837144	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:59837144G>C	uc001nom.2	+	6	739	c.611G>C	c.(610-612)AGA>ACA	p.R204T	MS4A3_uc001non.2_Missense_Mutation_p.R158T|MS4A3_uc001noo.2_Missense_Mutation_p.R81T	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	204	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				TGTAATTCAAGAGAGGTGAGA	0.403			NA											97	68					0	0	0.01441	0	0
PHOX2A	401	broad.mit.edu	37	11	71952288	71952288	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:71952288C>T	uc001osh.3	-	2	435	c.263G>A	c.(262-264)CGC>CAC	p.R88H		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	88					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCGCTGCTTGCGCTTCTCGTG	0.647			NA											16	32					0	0	0.006122	0	0
CAPN5	726	broad.mit.edu	37	11	76833722	76833722	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:76833722C>G	uc001oxx.2	+	12	1889	c.1704C>G	c.(1702-1704)TTC>TTG	p.F568L	CAPN5_uc009yup.2_Missense_Mutation_p.F608L|CAPN5_uc009yuq.2_Missense_Mutation_p.F604L|CAPN5_uc001oxy.2_Missense_Mutation_p.F608L|CAPN5_uc001oya.2_Missense_Mutation_p.F130L	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	568	C2.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						AAGGCATCTTCTACCGCAAGA	0.582			NA											69	24					0	0	0.01441	0	0
PRCP	5547	broad.mit.edu	37	11	82536054	82536054	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:82536054T>C	uc001ozs.2	-	9	1498	c.1385A>G	c.(1384-1386)AAG>AGG	p.K462R	PRCP_uc001ozr.2_Missense_Mutation_p.K483R	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	462					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						CAAGGCATTCTTGGTGCGGAG	0.502			NA											17	39					0	0	0.006122	0	0
GRIA4	2893	broad.mit.edu	37	11	105774606	105774606	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:105774606C>A	uc001pix.2	+	8	1398	c.952C>A	c.(952-954)CAG>AAG	p.Q318K	GRIA4_uc001piu.1_Missense_Mutation_p.Q318K|GRIA4_uc001piw.2_Missense_Mutation_p.Q318K|GRIA4_uc009yxk.1_Missense_Mutation_p.Q318K	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	318	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCTTAGGAGGCAGAAAATTGA	0.443			NA											8	90					3.09899e-07	3.5417e-07	0.004482	1	0
FAM55B	120406	broad.mit.edu	37	11	114569363	114569363	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:114569363G>A	uc009yyy.2	+	3	827	c.729G>A	c.(727-729)CAG>CAA	p.Q243Q		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	243						integral to membrane				ovary(1)	1						AACTGTGCCAGTACATGGATG	0.473			NA											16	40					0	0	0.004007	0	0
TECTA	7007	broad.mit.edu	37	11	121008503	121008503	+	Silent	SNP	C	C	T	rs142573400	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:121008503C>T	uc010rzo.1	+	10	3315	c.3315C>T	c.(3313-3315)TAC>TAT	p.Y1105Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1105	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCTCAGGCTACGGCCACTACC	0.582			NA											5	31					0	0	0.000602	0	0
SORL1	6653	broad.mit.edu	37	11	121476152	121476152	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:121476152G>C	uc001pxx.2	+	35	4900	c.4820G>C	c.(4819-4821)AGC>ACC	p.S1607T	SORL1_uc010rzp.1_Missense_Mutation_p.S453T|SORL1_uc010rzq.1_Missense_Mutation_p.S222T	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1607	Extracellular (Potential).|Fibronectin type-III 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GAGACCCACAGCAATAAGACA	0.448			NA											22	151					0	0	0.014323	0	0
NINJ2	4815	broad.mit.edu	37	12	674430	674430	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:674430C>A	uc001qil.2	-	3	629	c.538G>T	c.(538-540)GCT>TCT	p.A180S		NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	134	Extracellular (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			GCCCTGGCAGCCAGGAACCCT	0.562			NA											15	35					0.000308642	0.000339595	0.003163	1	0
CACNA1C	775	broad.mit.edu	37	12	2760808	2760808	+	Silent	SNP	C	C	T	rs150092451	by1000genomes	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:2760808C>T	uc009zdu.1	+	34	4405	c.4092C>T	c.(4090-4092)AAC>AAT	p.N1364N	CACNA1C_uc009zdv.1_Silent_p.N1313N|CACNA1C_uc001qkb.2_Silent_p.N1316N|CACNA1C_uc001qkc.2_Silent_p.N1316N|CACNA1C_uc001qke.2_Silent_p.N1305N|CACNA1C_uc001qkf.2_Silent_p.N1305N|CACNA1C_uc001qjz.2_Silent_p.N1316N|CACNA1C_uc001qkd.2_Silent_p.N1316N|CACNA1C_uc001qkg.2_Silent_p.N1303N|CACNA1C_uc009zdw.1_Silent_p.N1338N|CACNA1C_uc001qkh.2_Silent_p.N1305N|CACNA1C_uc001qkl.2_Silent_p.N1364N|CACNA1C_uc001qkn.2_Silent_p.N1316N|CACNA1C_uc001qko.2_Silent_p.N1336N|CACNA1C_uc001qkp.2_Silent_p.N1316N|CACNA1C_uc001qkr.2_Silent_p.N1333N|CACNA1C_uc001qku.2_Silent_p.N1316N|CACNA1C_uc001qkq.2_Silent_p.N1344N|CACNA1C_uc001qks.2_Silent_p.N1316N|CACNA1C_uc001qkt.2_Silent_p.N1316N|CACNA1C_uc001qki.1_Silent_p.N1052N|CACNA1C_uc001qkj.1_Silent_p.N1052N|CACNA1C_uc001qkk.1_Silent_p.N1052N|CACNA1C_uc001qkm.1_Silent_p.N1041N|CACNA1C_uc010sea.1_Silent_p.N7N	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1364	Extracellular (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTTCCAGAACGCAGAGGAAA	0.617			NA											28	73					0	0	0.013726	0	0
GDF3	9573	broad.mit.edu	37	12	7848123	7848123	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:7848123G>A	uc001qte.2	-	1	238	c.202C>T	c.(202-204)CGA>TGA	p.R68*		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	68					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						CATAAGTCTCGGGAGACCCCA	0.498			NA											6	71					0	0	0.001168	0	0
A2ML1	144568	broad.mit.edu	37	12	8995850	8995850	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:8995850C>T	uc001quz.3	+	12	1467	c.1369C>T	c.(1369-1371)CGG>TGG	p.R457W	A2ML1_uc001qva.1_Missense_Mutation_p.R37W|A2ML1_uc010sgm.1_5'Flank	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	301						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TGGCATCCACCGGCTAAACGG	0.542			NA											10	129					0	0	0.008291	0	0
GPRC5D	55507	broad.mit.edu	37	12	13102817	13102817	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:13102817C>T	uc010shp.1	-	1	502	c.502G>A	c.(502-504)GTG>ATG	p.V168M		NM_018654	NP_061124	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5,	168	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		ACAAAGTCCACATTGAGCTGG	0.478			NA											11	55					0	0	0.008291	0	0
PTPRO	5800	broad.mit.edu	37	12	15699627	15699627	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:15699627G>A	uc001rcv.1	+	13	2463	c.2289G>A	c.(2287-2289)CAG>CAA	p.Q763Q	PTPRO_uc001rcw.1_Silent_p.Q763Q|PTPRO_uc001rcx.1_5'UTR|PTPRO_uc001rcy.1_5'UTR|PTPRO_uc001rcz.1_5'UTR|PTPRO_uc001rda.1_5'UTR	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	763	Fibronectin type-III 8.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GCTCCAGTCAGAAAACCAAAC	0.393			NA											6	46					0	0	0.00308	0	0
ABCC9	10060	broad.mit.edu	37	12	22005368	22005368	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:22005368C>A	uc001rfi.1	-	21	2597	c.2577G>T	c.(2575-2577)CTG>CTT	p.L859L	ABCC9_uc001rfh.2_Silent_p.L859L|ABCC9_uc001rfj.1_Silent_p.L823L	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	859	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGTCATCTTGCAGGAATTTCA	0.403			NA											7	73					1.06961e-07	1.23714e-07	0.00308	1	0
FAR2	55711	broad.mit.edu	37	12	29446406	29446406	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:29446406C>G	uc001ris.3	+	3	510	c.363C>G	c.(361-363)CTC>CTG	p.L121L	FAR2_uc001rit.2_Silent_p.L121L|FAR2_uc009zjm.2_Silent_p.L24L|uc001riu.1_RNA	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	121					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						ACGACACTCTCAGGTACATTC	0.378			NA											9	122					0	0	0.006214	0	0
ALG10B	144245	broad.mit.edu	37	12	38714744	38714744	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:38714744T>C	uc001rln.3	+	3	1290	c.1151T>C	c.(1150-1152)ATA>ACA	p.I384T	ALG10B_uc001rlo.3_Missense_Mutation_p.I354T|ALG10B_uc010skk.1_Missense_Mutation_p.I324T	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	384	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GGTTGGAGTATAGCTGACTCA	0.308			NA											29	37					0	0	0.00632	0	0
PLEKHA9	51054	broad.mit.edu	37	12	45567729	45567729	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:45567729A>C	uc001rom.1	-	3	957	c.420T>G	c.(418-420)AGT>AGG	p.S140R	PLEKHA9_uc009zke.2_Missense_Mutation_p.S140R	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		TATTTTCCTCACTTGATATGC	0.318			NA											6	37					0	0	0.001168	0	0
OR8S1	341568	broad.mit.edu	37	12	48920124	48920124	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:48920124C>T	uc010slu.1	+	1	710	c.710C>T	c.(709-711)GCC>GTC	p.A237V		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGAAGCAAGGCCTTCTCCACC	0.517			NA											17	71					0	0	0.00499	0	0
TENC1	23371	broad.mit.edu	37	12	53452199	53452199	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:53452199C>A	uc001sbp.2	+	15	1330	c.1195C>A	c.(1195-1197)CCC>ACC	p.P399T	TENC1_uc001sbl.2_Missense_Mutation_p.P275T|TENC1_uc001sbn.2_Missense_Mutation_p.P409T|TENC1_uc001sbo.1_Missense_Mutation_p.P399T|TENC1_uc001sbq.2_5'UTR|TENC1_uc001sbr.2_5'Flank|TENC1_uc009zmr.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	399	C2 tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						GCTCACTTTCCCCAAGGACCA	0.498			NA											8	48					2.17888e-05	2.43224e-05	0.006214	1	0
USP15	9958	broad.mit.edu	37	12	62783422	62783422	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:62783422G>A	uc001src.1	+	13	1604	c.1595G>A	c.(1594-1596)AGA>AAA	p.R532K	USP15_uc001srb.1_Missense_Mutation_p.R503K	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	532					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AGATTTCACAGAATATTCGCT	0.284	Melanoma(181;615 2041 39364 49691 50001)		NA											19	92					0	0	0.010504	0	0
NAV3	89795	broad.mit.edu	37	12	78593140	78593140	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:78593140G>T	uc001syp.2	+	37	6717	c.6544G>T	c.(6544-6546)GAA>TAA	p.E2182*	NAV3_uc001syo.2_Nonsense_Mutation_p.E2160*|NAV3_uc010sub.1_Nonsense_Mutation_p.E1639*|NAV3_uc009zsf.2_Nonsense_Mutation_p.E991*	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2182						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAATCATACAGAACCAGTGAA	0.279			NA								HNSCC(70;0.22)			11	26					9.05144e-12	1.08617e-11	0.001855	1	0
CDK17	5128	broad.mit.edu	37	12	96691485	96691485	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:96691485C>G	uc001tep.1	-	8	1219	c.730G>C	c.(730-732)GAT>CAT	p.D244H	CDK17_uc009ztk.2_Missense_Mutation_p.D244H|CDK17_uc010svb.1_Missense_Mutation_p.D191H	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	244	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						TGTTTTAAATCCTTTAATAGT	0.303			NA											17	44					0	0	0.00499	0	0
ANO4	121601	broad.mit.edu	37	12	101504206	101504206	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:101504206T>C	uc010svm.1	+	23	2746	c.2174T>C	c.(2173-2175)ATC>ACC	p.I725T	ANO4_uc001thw.2_Missense_Mutation_p.I690T|ANO4_uc001thx.2_Missense_Mutation_p.I725T|ANO4_uc001thy.2_Missense_Mutation_p.I245T	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	725	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTCACAACTATCTTTGTGGCA	0.363			NA								HNSCC(74;0.22)			12	45					0	0	0.00245	0	0
C12orf45	121053	broad.mit.edu	37	12	105380132	105380132	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:105380132T>C	uc001tlb.2	+	1	35	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	1											0						GAGGGAAGCATGGAGGTCCAT	0.652			NA											5	7					0	0	0.000602	0	0
RNF10	9921	broad.mit.edu	37	12	121001687	121001687	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:121001687A>T	uc001typ.3	+	10	2089	c.1606A>T	c.(1606-1608)AGG>TGG	p.R536W	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.R447W	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	536					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCCTGGAGAGGAGCCCCGA	0.567			NA											33	77					0	0	0.004289	0	0
TMEM132D	121256	broad.mit.edu	37	12	129563160	129563160	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:129563160G>A	uc009zyl.1	-	8	2362	c.2034C>T	c.(2032-2034)CTC>CTT	p.L678L	TMEM132D_uc001uia.2_Silent_p.L216L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	678	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTGCAAGGAGAGTGACAGCC	0.572			NA											13	60					0	0	0.001855	0	0
USPL1	10208	broad.mit.edu	37	13	31205581	31205581	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr13:31205581C>G	uc001utc.2	+	4	1270	c.838C>G	c.(838-840)CTA>GTA	p.L280V	USPL1_uc001utb.2_Missense_Mutation_p.L99V|USPL1_uc001utd.2_Intron|USPL1_uc001ute.1_5'Flank	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	280					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AAATACACTTCTATATACCAG	0.284	Ovarian(60;318 1180 1554 28110 31601)		NA											24	11					0	0	0.00278	0	0
AKAP11	11215	broad.mit.edu	37	13	42877626	42877626	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr13:42877626C>G	uc001uys.1	+	8	4919	c.4744C>G	c.(4744-4746)CTT>GTT	p.L1582V		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1582					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTTGTCACCTCTTACAGGTCA	0.453			NA											17	18					0	0	0.004007	0	0
GPC6	10082	broad.mit.edu	37	13	95050757	95050757	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr13:95050757C>A	uc001vlt.2	+	8	1959	c.1327C>A	c.(1327-1329)CAG>AAG	p.Q443K		NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	443						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GCTCACCAACCAGATCAACAA	0.478			NA											19	20					7.87624e-14	9.66287e-14	0.00278	1	0
OR4M1	441670	broad.mit.edu	37	14	20248685	20248685	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:20248685C>A	uc010tku.1	+	1	204	c.204C>A	c.(202-204)CTC>CTA	p.L68L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCTGGCCCTCCTTGATATTT	0.423			NA											69	460					3.13743e-37	4.04286e-37	0.01441	1	0
OR4K14	122740	broad.mit.edu	37	14	20482822	20482822	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:20482822G>A	uc010tky.1	-	1	531	c.531C>T	c.(529-531)AGC>AGT	p.S177S		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CACAGAAGAAGCTGTCTACCT	0.488			NA											14	33					0	0	0.003163	0	0
ACIN1	22985	broad.mit.edu	37	14	23530555	23530555	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:23530555G>T	uc001wit.3	-	17	3878	c.3550C>A	c.(3550-3552)CGC>AGC	p.R1184S	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.R426S|ACIN1_uc001wiq.3_Missense_Mutation_p.R426S|ACIN1_uc001wir.3_Missense_Mutation_p.R457S|ACIN1_uc001wis.3_Missense_Mutation_p.R865S|ACIN1_uc010akg.2_Missense_Mutation_p.R1171S	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1184	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCCTTGCGGCGGCGGTCACGG	0.562			NA											16	82					0.00316338	0.00341218	0.003163	1	0
ACIN1	22985	broad.mit.edu	37	14	23549752	23549752	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:23549752C>G	uc001wit.3	-	6	1294	c.966G>C	c.(964-966)GAG>GAC	p.E322D	ACIN1_uc001wis.3_Missense_Mutation_p.E4D|ACIN1_uc010akg.2_Missense_Mutation_p.E322D|ACIN1_uc010tnj.1_Missense_Mutation_p.E282D	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	322	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TTTTGGGTCTCTCATCCATCA	0.463			NA											14	50					0	0	0.005443	0	0
ACIN1	22985	broad.mit.edu	37	14	23549790	23549790	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:23549790C>G	uc001wit.3	-	6	1256	c.928G>C	c.(928-930)GAG>CAG	p.E310Q	ACIN1_uc001wis.3_5'UTR|ACIN1_uc010akg.2_Missense_Mutation_p.E310Q|ACIN1_uc010tnj.1_Missense_Mutation_p.E270Q	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	310	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CTAGGTATCTCTTCCCCTTCT	0.378			NA											19	58					0	0	0.003271	0	0
DAAM1	23002	broad.mit.edu	37	14	59830421	59830421	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:59830421C>G	uc001xdz.1	+	24	2902	c.2777C>G	c.(2776-2778)TCT>TGT	p.S926C	DAAM1_uc001xea.1_Missense_Mutation_p.S916C|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	926	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AAGTTTGTGTCTGTTGTCAGC	0.463			NA											23	23					0	0	0.00278	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72169178	72169178	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:72169178C>T	uc001xms.2	+	12	3950	c.3602C>T	c.(3601-3603)ACG>ATG	p.T1201M	SIPA1L1_uc001xmt.2_Missense_Mutation_p.T1201M|SIPA1L1_uc001xmu.2_Missense_Mutation_p.T1201M|SIPA1L1_uc001xmv.2_Missense_Mutation_p.T1201M|SIPA1L1_uc010ttm.1_Missense_Mutation_p.T676M|SIPA1L1_uc001xmw.2_Translation_Start_Site	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1201					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GGAAAATCCACGCCTAGCTGG	0.478			NA											25	28					0	0	0.00333	0	0
SERPINA12	145264	broad.mit.edu	37	14	94962778	94962778	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:94962778C>A	uc001ydj.2	-	4	1633	c.837G>T	c.(835-837)AAG>AAT	p.K279N		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	279					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		AGTGCTTCAGCTTGCCCTCAT	0.473			NA											50	71					3.94638e-17	4.95232e-17	0.01441	1	0
MTA1	9112	broad.mit.edu	37	14	105911754	105911754	+	Splice_Site	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:105911754G>C	uc001yqx.2	+	3	284	c.97_splice	c.e3-1	p.T33_splice	MTA1_uc001yqy.2_Splice_Site|MTA1_uc001yqz.1_Splice_Site|MTA1_uc001yra.1_Splice_Site	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein						signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		TGCTGTTACAGACGGCCAATG	0.647			NA											20	50					0	0	0.014323	0	0
HERC2	8924	broad.mit.edu	37	15	28517458	28517458	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:28517458G>C	uc001zbj.2	-	9	1092	c.986C>G	c.(985-987)TCC>TGC	p.S329C	HERC2_uc001zbl.1_Missense_Mutation_p.S24C	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	329					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCCCTGGGCGGAACGCTCATT	0.542			NA											5	23					0	0	0.000602	0	0
C15orf54	400360	broad.mit.edu	37	15	39544847	39544847	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:39544847G>A	uc001zkg.2	+	2	879	c.511G>A	c.(511-513)GAA>AAA	p.E171K		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	171											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		TCATTTCATTGAAGTGTTCAA	0.453			NA											22	38					0	0	0.012319	0	0
CDAN1	146059	broad.mit.edu	37	15	43020852	43020852	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:43020852C>T	uc001zql.2	-	20	2919	c.2802G>A	c.(2800-2802)CGG>CGA	p.R934R	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Silent_p.R260R	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	934						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTGCTTACTCCCGCCCCAGGG	0.408			NA											18	42					0	0	0.010504	0	0
CILP	8483	broad.mit.edu	37	15	65499247	65499247	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:65499247C>A	uc002aon.2	-	4	478	c.297G>T	c.(295-297)TGG>TGT	p.W99C		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	99					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCGCAGGTGTCCAGTCAGTGG	0.632			NA											12	17					3.07112e-06	3.44827e-06	0.010729	1	0
HCN4	10021	broad.mit.edu	37	15	73614946	73614946	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:73614946G>T	uc002avp.2	-	8	4482	c.3488C>A	c.(3487-3489)CCC>CAC	p.P1163H		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	1163	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		AGACAGAGGGGGTGGCAAAGA	0.677			NA											11	10					2.80697e-09	3.30637e-09	0.010729	1	0
ISLR2	57611	broad.mit.edu	37	15	74425518	74425518	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:74425518C>T	uc002axd.2	+	4	1192	c.423C>T	c.(421-423)GAC>GAT	p.D141D	ISLR2_uc002axe.2_Silent_p.D141D|ISLR2_uc010bjg.2_Silent_p.D141D|ISLR2_uc010bjf.2_Silent_p.D141D	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	141	LRR 4.|Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						TGCCCCGGGACGCACTCGGTG	0.637			NA											10	104					0	0	0.006214	0	0
ALPK3	57538	broad.mit.edu	37	15	85411403	85411403	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:85411403C>T	uc002ble.2	+	14	5607	c.5440C>T	c.(5440-5442)CAG>TAG	p.Q1814*	ALPK3_uc010upc.1_Nonsense_Mutation_p.Q115*	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1814	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCCTCCCACCAGTGCAATGC	0.632			NA											118	134					0	0	0.01441	0	0
NTRK3	4916	broad.mit.edu	37	15	88423650	88423650	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:88423650G>A	uc002bme.1	-	18	2347	c.2185C>T	c.(2185-2187)CAC>TAC	p.H729Y	NTRK3_uc002bmh.2_Missense_Mutation_p.H707Y|NTRK3_uc002bmf.1_Missense_Mutation_p.H715Y	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	729	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCATGGTGTGTCCTCCCACC	0.507			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			4	51					0	0	0.000602	0	0
UNC45A	55898	broad.mit.edu	37	15	91479540	91479540	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:91479540C>G	uc002bqg.2	+	4	616	c.276C>G	c.(274-276)GTC>GTG	p.V92V	UNC45A_uc002bqd.2_Silent_p.V77V|UNC45A_uc010uqo.1_Silent_p.V84V|UNC45A_uc010uqp.1_RNA|UNC45A_uc010uqq.1_Silent_p.V92V	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	92	TPR 3.				cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GTGGGGATGTCAAAGCACTCT	0.577			NA											42	69					0	0	0.01441	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266186	3266186	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:3266186C>A	uc010uwv.1	+	1	625	c.477C>A	c.(475-477)CAC>CAA	p.H159Q		NR_002169				RecName: Full=Olfactory receptor 1F2; AltName: Full=OLFmf2;												0						CAGACACACACCTCAGTGAAG	0.522			NA											32	31					5.45727e-16	6.80387e-16	0.008361	1	0
DNAH3	55567	broad.mit.edu	37	16	20996669	20996669	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:20996669T>C	uc010vbe.1	-	48	7395	c.7395A>G	c.(7393-7395)GCA>GCG	p.A2465A	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2465	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGTCATTGCCTGCGTAGTTCT	0.537			NA											31	14					0	0	0.007291	0	0
DNAH3	55567	broad.mit.edu	37	16	21069459	21069459	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:21069459G>T	uc010vbe.1	-	27	3872	c.3872C>A	c.(3871-3873)TCC>TAC	p.S1291Y		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1291	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CCAAAAGATGGAGGAGACACA	0.488			NA											8	44					0.00621372	0.00668366	0.006214	1	0
RABEP2	79874	broad.mit.edu	37	16	28916339	28916339	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:28916339A>G	uc002drq.2	-	13	1683	c.1635T>C	c.(1633-1635)GCT>GCC	p.A545A	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.A474A|RABEP2_uc010byn.2_Silent_p.A509A	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	545					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CCAGGGTCTCAGCCTGGCGGA	0.652	Pancreas(66;639 1284 10093 31061 49099)		NA											18	17					0	0	0.007413	0	0
HSD3B7	80270	broad.mit.edu	37	16	30999232	30999232	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:30999232G>T	uc002eaf.2	+	7	944	c.838G>T	c.(838-840)GGA>TGA	p.G280*	HSD3B7_uc010cac.2_3'UTR|HSD3B7_uc002eag.2_3'UTR|HSD3B7_uc002eah.2_Nonsense_Mutation_p.G280*	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	280					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						GGGCCCCTGCGGACTGCGGCT	0.642			NA											114	76					4.37143e-48	5.67104e-48	0.01441	1	0
ZNF423	23090	broad.mit.edu	37	16	49672682	49672682	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:49672682G>A	uc002efs.2	-	5	679	c.381C>T	c.(379-381)CTC>CTT	p.L127L	ZNF423_uc010vgn.1_Silent_p.L10L	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	127					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CCTCCTCGCCGAGGCCGAGGT	0.602			NA											28	15					0	0	0.005443	0	0
PDPR	55066	broad.mit.edu	37	16	70166109	70166109	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:70166109G>T	uc002eyf.1	+	9	1860	c.903G>T	c.(901-903)CTG>CTT	p.L301L	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Silent_p.L201L|PDPR_uc002eyg.1_Silent_p.L29L	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	301					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		GTGGCATCCTGTCTGGGGGCT	0.468			NA											23	59					3.62531e-18	4.56432e-18	0.004289	1	0
MTHFSD	64779	broad.mit.edu	37	16	86565716	86565716	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:86565716G>A	uc002fjn.2	-	8	1104	c.1053C>T	c.(1051-1053)GAC>GAT	p.D351D	MTHFSD_uc010voo.1_Silent_p.D331D|MTHFSD_uc002fjo.2_Silent_p.D188D|MTHFSD_uc002fjm.2_Silent_p.D350D|MTHFSD_uc010vop.1_Silent_p.D188D|MTHFSD_uc010voq.1_Silent_p.D350D|MTHFSD_uc010vor.1_Silent_p.D351D	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	351	RRM.				folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						CTGCGGCAGAGTCCGGGTAAT	0.701			NA											7	20					0	0	0.001984	0	0
TP53	7157	broad.mit.edu	37	17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	10					0	0	0.001855	0	0
MYOCD	93649	broad.mit.edu	37	17	12666905	12666905	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:12666905G>C	uc002gnn.2	+	13	3060	c.2761G>C	c.(2761-2763)GAT>CAT	p.D921H	MYOCD_uc002gno.2_Missense_Mutation_p.D969H|MYOCD_uc002gnq.2_Missense_Mutation_p.D645H	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	921					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CGATTTCCTGGATGTCACTGA	0.512			NA											3	34					0	0	0.004672	0	0
ELAC2	60528	broad.mit.edu	37	17	12905612	12905612	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:12905612C>A	uc002gnz.3	-	14	1378	c.1283G>T	c.(1282-1284)CGT>CTT	p.R428L	ELAC2_uc002gnu.3_5'Flank|ELAC2_uc002gnv.3_Missense_Mutation_p.R56L|ELAC2_uc002gnw.3_Missense_Mutation_p.R86L|ELAC2_uc002gnx.3_Missense_Mutation_p.R188L|ELAC2_uc010vvo.1_Missense_Mutation_p.R226L|ELAC2_uc010vvp.1_Missense_Mutation_p.R409L|ELAC2_uc010vvq.1_Missense_Mutation_p.R427L|ELAC2_uc010vvr.1_Missense_Mutation_p.R388L	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	428					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						CCTCCTGGGACGGAGCTGGTA	0.423			NA							Hereditary_Prostate_Cancer				14	30					1.3612e-06	1.54189e-06	0.003163	1	0
FLCN	201163	broad.mit.edu	37	17	17131313	17131313	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:17131313C>G	uc002gra.3	-	4	643	c.139G>C	c.(139-141)GAA>CAA	p.E47Q	PLD6_uc010cpn.2_RNA|FLCN_uc002grb.3_Missense_Mutation_p.E47Q|FLCN_uc002grc.2_Missense_Mutation_p.E47Q	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	47					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						CCTTCCTCTTCTTCCGCCTGC	0.652			NA							Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				19	24					0	0	0.008871	0	0
MYO15A	51168	broad.mit.edu	37	17	18051508	18051508	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:18051508C>T	uc010vxh.1	+	30	7013	c.6675C>T	c.(6673-6675)GAC>GAT	p.D2225D		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2225	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGGCGCTGGACGTGGGCTGCT	0.672			NA											5	34					0	0	0.001984	0	0
SSH2	85464	broad.mit.edu	37	17	27959598	27959598	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:27959598C>T	uc002heo.1	-	15	2533	c.2533G>A	c.(2533-2535)GAG>AAG	p.E845K	SSH2_uc010wbh.1_Missense_Mutation_p.E872K	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	845					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TGTTCCCCCTCAGCTGGTTCC	0.577			NA											23	177					0	0	0.014323	0	0
SYNRG	11276	broad.mit.edu	37	17	35937553	35937553	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:35937553C>G	uc002hoa.2	-	7	831	c.748G>C	c.(748-750)GAT>CAT	p.D250H	SYNRG_uc010wde.1_Intron|SYNRG_uc010wdf.1_Intron|SYNRG_uc002hoc.2_Intron|SYNRG_uc002hoe.2_Intron|SYNRG_uc002hod.2_Intron|SYNRG_uc010wdg.1_Intron|SYNRG_uc002hob.2_Missense_Mutation_p.D250H|SYNRG_uc002hof.2_5'Flank|SYNRG_uc010cvd.1_Intron|SYNRG_uc002hog.1_Missense_Mutation_p.D384H|SYNRG_uc010wdh.1_Missense_Mutation_p.D351H	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	250					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						ACACATCCATCTACAGCAACC	0.438			NA											117	518					0	0	0.01441	0	0
FBXL20	84961	broad.mit.edu	37	17	37425091	37425091	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:37425091C>T	uc010wed.1	-	12	1143	c.922G>A	c.(922-924)GAG>AAG	p.E308K	FBXL20_uc002hrt.2_Missense_Mutation_p.E308K|FBXL20_uc010cvu.2_Missense_Mutation_p.E276K	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	308	LRR 9.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			TGAACACACTCTTCCAGGTCC	0.328			NA											28	223					0	0	0.009535	0	0
CDK12	51755	broad.mit.edu	37	17	37619117	37619117	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:37619117A>C	uc010cvv.2	+	1	1379	c.793A>C	c.(793-795)AGT>CGT	p.S265R	CDK12_uc010wef.1_Missense_Mutation_p.S265R|CDK12_uc002hrw.3_Missense_Mutation_p.S265R	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	265					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CTACAAGAAAAGTCCTGGAAG	0.537			NA								TCGA Ovarian(9;0.13)			29	304					0	0	0.00632	0	0
THRA	7067	broad.mit.edu	37	17	38243028	38243028	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:38243028C>T	uc002htw.2	+	7	1128	c.645C>T	c.(643-645)TTC>TTT	p.F215F	THRA_uc010cwp.1_Silent_p.F215F|THRA_uc002htv.2_Silent_p.F215F|THRA_uc002htx.2_Silent_p.F215F	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	215	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TGGAAGCCTTCAGCGAGTTTA	0.582			NA									OREG0024390	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	142					0	0	0.006214	0	0
THRA	7067	broad.mit.edu	37	17	38244755	38244755	+	Splice_Site	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:38244755T>C	uc002htw.2	+	8	1465	c.982_splice	c.e8+2	p.D328_splice	THRA_uc010cwp.1_Splice_Site_p.D328_splice|THRA_uc002htv.2_Splice_Site_p.D328_splice|THRA_uc002htx.2_Splice_Site_p.D328_splice	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2						negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TGTCAACAGGTACCTGCTGAT	0.557			NA											12	236					0	0	0.013537	0	0
KRT10	3858	broad.mit.edu	37	17	38975393	38975393	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:38975393C>T	uc002hvi.2	-	7	1420	c.1394G>A	c.(1393-1395)GGC>GAC	p.G465D	KRT10_uc010cxd.2_Intron|TMEM99_uc002hvj.1_5'UTR	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	465	Gly-rich.|Tail.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				acttccgccgccgcgtccgcc	0.184			NA											11	22					0	0	0.013537	0	0
KRT17	3872	broad.mit.edu	37	17	39777023	39777023	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:39777023G>A	uc002hxh.2	-	6	1190	c.1069C>T	c.(1069-1071)CGC>TGC	p.R357C	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	357	Coil 2.|Rod.			R -> L (in Ref. 4; AL353997/AC022596).	epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				ATCTCGCAGCGAAGCTGGGCC	0.627	Pancreas(92;1242 2086 39193 50508)		NA							Steatocystoma_Multiplex				20	120					0	0	0.012319	0	0
HOXB2	3212	broad.mit.edu	37	17	46620955	46620955	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:46620955G>A	uc002inm.2	-	2	666	c.546C>T	c.(544-546)CTC>CTT	p.L182L		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	182	Homeobox.				blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCTTTCGGTGAGGTCCAGCA	0.612			NA											28	182					0	0	0.009535	0	0
CYB561	1534	broad.mit.edu	37	17	61511886	61511886	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:61511886G>A	uc002jap.2	-	5	1035	c.633C>T	c.(631-633)TTC>TTT	p.F211F	CYB561_uc002jaq.2_Silent_p.F257F|CYB561_uc002jar.2_Silent_p.F211F|CYB561_uc002jas.2_Silent_p.F211F|CYB561_uc010ddt.2_3'UTR|CYB561_uc002jat.2_Silent_p.F211F|CYB561_uc010wpf.1_3'UTR|CYB561_uc010wpg.1_Silent_p.F182F	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	211	Cytochrome b561.|Helical; (Potential).				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		CCGCCCCACCGAAGCAGGCCA	0.652			NA											5	36					0	0	0.000602	0	0
KIAA0195	9772	broad.mit.edu	37	17	73485368	73485368	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:73485368G>T	uc002jnz.3	+	8	1061	c.786G>T	c.(784-786)CTG>CTT	p.L262L	KIAA0195_uc010wsa.1_Silent_p.L272L|KIAA0195_uc010wsb.1_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	262					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACATGGCCCTGTCCCGACCAG	0.582			NA											10	29					4.68919e-08	5.44003e-08	0.008291	1	0
EPB41L3	23136	broad.mit.edu	37	18	5489114	5489114	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:5489114C>A	uc002kmt.1	-	2	155	c.69G>T	c.(67-69)GCG>GCT	p.A23A	EPB41L3_uc010wzh.1_Silent_p.A23A|EPB41L3_uc002kmu.1_Silent_p.A23A|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Silent_p.A45A|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	23					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						cctgcgcccccgccgccTCCT	0.517			NA											19	20					7.45023e-12	8.9683e-12	0.010504	1	0
CEP76	79959	broad.mit.edu	37	18	12686344	12686344	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:12686344C>G	uc002kri.2	-	8	1195	c.1039G>C	c.(1039-1041)GGT>CGT	p.G347R	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_Missense_Mutation_p.G169R|CEP76_uc010wzz.1_Missense_Mutation_p.G272R|CEP76_uc010xaa.1_Missense_Mutation_p.G169R	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	347					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						CGTTCATAACCAAGGACATTA	0.443			NA											9	20					0	0	0.006214	0	0
C18orf19	125228	broad.mit.edu	37	18	13682015	13682015	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:13682015T>C	uc010dlh.2	-	3	494	c.62A>G	c.(61-63)CAT>CGT	p.H21R	C18orf19_uc010dlg.2_Missense_Mutation_p.H21R|C18orf19_uc010dli.2_Missense_Mutation_p.H21R|C18orf19_uc002ksj.3_Missense_Mutation_p.H21R|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	21						integral to membrane				breast(2)	2						ACCAGCATTATGTGGTTCCAA	0.418			NA											16	49					0	0	0.00499	0	0
KIAA0427	9811	broad.mit.edu	37	18	46343675	46343675	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:46343675C>T	uc002ldc.2	+	10	1740	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F	KIAA0427_uc002ldd.2_Silent_p.F487F|KIAA0427_uc002lde.3_Silent_p.F114F	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	485	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						GCGAGGTCTTCGGCACCATGC	0.647			NA											12	48					0	0	0.013537	0	0
MBD1	4152	broad.mit.edu	37	18	47801575	47801575	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:47801575A>G	uc010dow.1	-	9	1270	c.833T>C	c.(832-834)ATG>ACG	p.M278T	MBD1_uc002lef.2_Missense_Mutation_p.M85T|MBD1_uc002leg.2_Missense_Mutation_p.M229T|MBD1_uc010xdi.1_Missense_Mutation_p.M329T|MBD1_uc002leh.3_Missense_Mutation_p.M278T|MBD1_uc002len.2_Missense_Mutation_p.M278T|MBD1_uc002lei.3_Missense_Mutation_p.M278T|MBD1_uc002lej.3_Missense_Mutation_p.M278T|MBD1_uc002lek.3_Missense_Mutation_p.M229T|MBD1_uc002lel.3_Missense_Mutation_p.M278T|MBD1_uc002lem.3_Missense_Mutation_p.M278T|MBD1_uc010xdj.1_Missense_Mutation_p.M278T|MBD1_uc010xdk.1_Missense_Mutation_p.M303T|MBD1_uc010dox.1_Missense_Mutation_p.M278T|MBD1_uc002leo.2_Missense_Mutation_p.M278T	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	278					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTGGCAGCCATCTTGGAGTC	0.647			NA											14	47					0	0	0.00499	0	0
ZNF77	58492	broad.mit.edu	37	19	2934107	2934107	+	Nonsense_Mutation	SNP	G	G	A	rs146879198	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:2934107G>A	uc002lws.3	-	4	1149	c.1018C>T	c.(1018-1020)CGA>TGA	p.R340*		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	340	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CCATGTTCTCGAAGAGACGAG	0.493			NA											24	47					0	0	0.014323	0	0
SEMA6B	10501	broad.mit.edu	37	19	4548324	4548324	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:4548324A>G	uc010duc.1	-	12	1443	c.1405T>C	c.(1405-1407)TCT>CCT	p.S469P	SEMA6B_uc010dud.2_Missense_Mutation_p.S469P|SEMA6B_uc010xih.1_Missense_Mutation_p.S469P	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	469	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGAGCCCAGACGTCCCTGAG	0.647			NA											36	25					0	0	0.004289	0	0
KEAP1	9817	broad.mit.edu	37	19	10602822	10602822	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:10602822C>A	uc002moq.1	-	3	912	c.756G>T	c.(754-756)TGG>TGT	p.W252C	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.W252C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	252	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGTACTTGACCCAGTTGATGC	0.622			NA											44	23					1.8453e-21	2.35413e-21	0.010771	1	0
CYP4F3	4051	broad.mit.edu	37	19	15760024	15760024	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:15760024C>T	uc002nbj.2	+	6	630	c.580C>T	c.(580-582)CAC>TAC	p.H194Y	CYP4F3_uc010xok.1_Missense_Mutation_p.H194Y|CYP4F3_uc010xol.1_Missense_Mutation_p.H194Y|CYP4F3_uc010xom.1_Missense_Mutation_p.H45Y|CYP4F3_uc002nbk.2_Missense_Mutation_p.H194Y|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	194					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						CATGTTTGAGCACATCAGCCT	0.577			NA											73	30					0	0	0.01441	0	0
ZFP14	57677	broad.mit.edu	37	19	36831959	36831959	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:36831959C>T	uc002odx.1	-	4	862	c.769G>A	c.(769-771)GAA>AAA	p.E257K	ZFP14_uc010xtd.1_Missense_Mutation_p.E258K|ZFP14_uc010eex.1_Missense_Mutation_p.E257K	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	257	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TCCTTACATTCATAGGGTTTT	0.448			NA											57	26					0	0	0.01441	0	0
MEGF8	1954	broad.mit.edu	37	19	42861133	42861133	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:42861133G>A	uc002otl.3	+	26	5264	c.4629G>A	c.(4627-4629)AAG>AAA	p.K1543K	MEGF8_uc002otm.3_Silent_p.K1151K	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1610	Extracellular (Potential).|Kelch 8.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GGCAGGAGAAGGTGAGCATCT	0.622			NA											5	9					0	0	0.001168	0	0
TMEM143	55260	broad.mit.edu	37	19	48845932	48845932	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:48845932T>C	uc002pix.1	-	6	839	c.830A>G	c.(829-831)CAG>CGG	p.Q277R	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.Q242R|TMEM143_uc010xzn.1_Missense_Mutation_p.Q212R|TMEM143_uc010elw.1_Missense_Mutation_p.Q177R|TMEM143_uc010xzo.1_Missense_Mutation_p.Q67R	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	277						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		CAGGGCGCGCTGCAGGGTGGG	0.637			NA											3	34					0	0	0.004672	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49969066	49969066	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:49969066T>A	uc002pnt.2	+	13	1756	c.1640T>A	c.(1639-1641)ATC>AAC	p.I547N	ALDH16A1_uc010yar.1_Missense_Mutation_p.I496N|ALDH16A1_uc010yas.1_Missense_Mutation_p.I382N|ALDH16A1_uc010yat.1_Missense_Mutation_p.I384N	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	547							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TCCAGGCCCATCCGGGATTCG	0.647			NA											4	30					0	0	0.009096	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021288	51021288	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:51021288G>A	uc002pss.2	-	3	1819	c.1682C>T	c.(1681-1683)ACG>ATG	p.T561M		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	561	Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GGCGTTCTCCGTCACATCCGT	0.657			NA											12	27					0	0	0.010729	0	0
ZNF175	7728	broad.mit.edu	37	19	52090283	52090283	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:52090283C>T	uc002pxb.2	+	5	1077	c.699C>T	c.(697-699)TTC>TTT	p.F233F		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	233					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GTCAGCTATTCAGCCATAGCT	0.423			NA											18	33					0	0	0.007413	0	0
ZNF528	84436	broad.mit.edu	37	19	52905244	52905244	+	Translation_Start_Site	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:52905244A>T	uc002pzh.2	+	4	404	c.-22A>T	c.(-24--20)GAAGA>GATGA		ZNF528_uc002pzi.2_Translation_Start_Site	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GCAACTTGGAAGAGGAAAGAA	0.418			NA											7	14					0	0	0.00308	0	0
BIRC8	112401	broad.mit.edu	37	19	53793115	53793115	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:53793115C>G	uc002qbk.2	-	1	1761	c.513G>C	c.(511-513)CAG>CAC	p.Q171H		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	171					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		TGATTTCTCTCTGCAATGAAG	0.433			NA											23	48					0	0	0.012319	0	0
NLRP7	199713	broad.mit.edu	37	19	55452960	55452960	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:55452960C>T	uc002qih.3	-	2	196	c.120G>A	c.(118-120)AAG>AAA	p.K40K	NLRP7_uc002qig.3_Silent_p.K40K|NLRP7_uc002qii.3_Silent_p.K40K|NLRP7_uc010esk.2_Silent_p.K40K|NLRP7_uc010esl.2_Silent_p.K68K	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	40	DAPIN.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ACCATGGGGTCTTCTGTAGCA	0.478			NA											25	56					0	0	0.00333	0	0
USP29	57663	broad.mit.edu	37	19	57640670	57640670	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:57640670C>G	uc002qny.2	+	4	983	c.627C>G	c.(625-627)AAC>AAG	p.N209K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	209					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATAGGAAGAACCCATCAAGTT	0.353			NA											10	54					0	0	0.008291	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565065	58565065	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:58565065C>T	uc002qrc.1	+	6	1120	c.873C>T	c.(871-873)CCC>CCT	p.P291P		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	291					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GTGGGCGGCCCTTCCAGTGTG	0.652			NA											6	65					0	0	0.001984	0	0
ZNF544	27300	broad.mit.edu	37	19	58773169	58773169	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:58773169G>C	uc010euo.2	+	7	1671	c.1197G>C	c.(1195-1197)CAG>CAC	p.Q399H	ZNF544_uc010yhw.1_RNA|ZNF544_uc010yhx.1_Missense_Mutation_p.Q371H|ZNF544_uc010yhy.1_Missense_Mutation_p.Q371H|ZNF544_uc002qrt.3_Missense_Mutation_p.Q257H|ZNF544_uc002qru.3_Missense_Mutation_p.Q257H|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	399	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TCATACATCAGAGGACACACA	0.463			NA											9	53					0	0	0.006214	0	0
PXDN	7837	broad.mit.edu	37	2	1657494	1657494	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:1657494A>G	uc002qxa.2	-	16	2074	c.2010T>C	c.(2008-2010)GTT>GTC	p.V670V	PXDN_uc002qxb.1_Silent_p.V670V	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	670					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTGCCTGTTCAACTGTGTAAG	0.498			NA											4	2					0	0	0.009096	0	0
C2orf48	348738	broad.mit.edu	37	2	10282472	10282472	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:10282472A>G	uc002rai.1	+	3	452	c.163A>G	c.(163-165)AGT>GGT	p.S55G		NM_182626	NP_872432	Q96LS8	CB048_HUMAN	hypothetical protein LOC348738	55											0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		ggggtgcgccagtggaagcgg	0.104			NA											19	101					0	0	0.00278	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27886720	27886720	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:27886720G>A	uc002rlk.3	+	1	383	c.101G>A	c.(100-102)AGG>AAG	p.R34K	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	34						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GACGTGGACAGGAACGTAAAG	0.572			NA											21	80					0	0	0.008871	0	0
ALK	238	broad.mit.edu	37	2	30142880	30142880	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:30142880G>C	uc002rmy.2	-	1	1553	c.646C>G	c.(646-648)CTC>GTC	p.L216V		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	216	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ATCTGGAAGAGAAGGCGGGGC	0.562			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				19	12					0	0	0.010504	0	0
GALNT14	79623	broad.mit.edu	37	2	31165110	31165110	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:31165110C>T	uc002rnr.2	-	9	1507	c.888G>A	c.(886-888)GGG>GGA	p.G296G	GALNT14_uc002rnq.2_Silent_p.G276G|GALNT14_uc002rns.2_Silent_p.G301G|GALNT14_uc010ymr.1_Silent_p.G261G|GALNT14_uc010ezo.1_Silent_p.G263G|GALNT14_uc010ezp.1_Intron	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	296	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TATCATATTTCCCCAGGTAAT	0.493			NA											48	19					0	0	0.01441	0	0
BIRC6	57448	broad.mit.edu	37	2	32800426	32800426	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:32800426C>T	uc010ezu.2	+	66	13482	c.13348C>T	c.(13348-13350)CGT>TGT	p.R4450C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4450					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTATACCAACCGTTTAAGGTA	0.358	Pancreas(94;175 1509 16028 18060 45422)		NA											43	26					0	0	0.00874	0	0
EPAS1	2034	broad.mit.edu	37	2	46607470	46607470	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:46607470G>C	uc002ruv.2	+	12	2147	c.1659G>C	c.(1657-1659)GCG>GCC	p.A553A	EPAS1_uc002ruw.2_Silent_p.A19A	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	553					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GGCTCTTGGCGGAGAACCCAC	0.597			NA											108	39					0	0	0.01441	0	0
NRXN1	9378	broad.mit.edu	37	2	50149334	50149334	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:50149334G>A	uc010fbp.2	-	6	1884	c.1077C>T	c.(1075-1077)ATC>ATT	p.I359I	NRXN1_uc002rxb.3_Silent_p.I1093I|NRXN1_uc010fbq.2_Silent_p.I1464I|NRXN1_uc002rxe.3_Silent_p.I1394I|NRXN1_uc010yon.1_Silent_p.I59I|NRXN1_uc002rxa.3_Silent_p.I56I	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	359	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGGACTCCCGGATCACTTCTG	0.532			NA											15	41					0	0	0.004007	0	0
VPS54	51542	broad.mit.edu	37	2	64169644	64169644	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:64169644G>C	uc002scq.2	-	11	1516	c.1353C>G	c.(1351-1353)CTC>CTG	p.L451L	VPS54_uc002scp.2_Silent_p.L439L|VPS54_uc010fct.2_Silent_p.L298L	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	451					protein transport|retrograde transport, endosome to Golgi						0						AAATATCCTTGAGCAGATCAA	0.328			NA											12	12					0	0	0.003163	0	0
C2orf78	388960	broad.mit.edu	37	2	74042383	74042383	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:74042383C>T	uc002sjr.1	+	3	1154	c.1033C>T	c.(1033-1035)CTC>TTC	p.L345F		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	345										ovary(2)	2						TCCTACTAATCTCTTGACACT	0.438			NA											26	32					0	0	0.00333	0	0
LIPT1	51601	broad.mit.edu	37	2	99778437	99778437	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:99778437C>T	uc002szm.3	+	4	357	c.17C>T	c.(16-18)TCA>TTA	p.S6L	MRPL30_uc002szl.1_Intron|LIPT1_uc002szn.3_Missense_Mutation_p.S6L|LIPT1_uc002szo.3_Missense_Mutation_p.S6L|LIPT1_uc002szp.3_Missense_Mutation_p.S6L|LIPT1_uc002szq.3_Missense_Mutation_p.S6L|MRPL30_uc002szr.2_Intron	NM_145198	NP_660199	Q9Y234	LIPT_HUMAN	lipoyltransferase 1 precursor	6					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity				0					Lipoic Acid(DB00166)	ATCCCATTTTCAATGAAGAAT	0.323	GBM(84;665 1268 21657 25485 30647)		NA											17	12					0	0	0.007413	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460238	107460238	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:107460238G>T	uc002tdq.2	-	2	315	c.196C>A	c.(196-198)CAT>AAT	p.H66N	ST6GAL2_uc002tdr.2_Missense_Mutation_p.H66N|ST6GAL2_uc002tds.3_Missense_Mutation_p.H66N	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	66	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GAGGGCTCATGTGCGGCGCCC	0.706			NA											7	39					5.4927e-09	6.43048e-09	0.004482	1	0
ARHGEF4	50649	broad.mit.edu	37	2	131797647	131797647	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:131797647G>A	uc002tsa.1	+	7	1326	c.806G>A	c.(805-807)GGA>GAA	p.G269E	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Missense_Mutation_p.G269E|ARHGEF4_uc010fmx.1_Missense_Mutation_p.G269E|ARHGEF4_uc002tsc.1_5'UTR	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	269					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		GGGAACAGCGGAGCGGAGGAC	0.672			NA											5	12					0	0	0.000602	0	0
CCDC148	130940	broad.mit.edu	37	2	159196885	159196885	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:159196885G>C	uc002tzq.2	-	5	618	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	CCDC148_uc002tzr.2_Intron|CCDC148_uc010foh.2_Intron|CCDC148_uc010foi.1_Missense_Mutation_p.Q66E|CCDC148_uc010foj.1_Intron|CCDC148_uc010fok.1_Missense_Mutation_p.Q33E|CCDC148_uc002tzs.1_Missense_Mutation_p.Q119E	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	119										ovary(2)	2						TATGTGCACTGTTGTTCTGAT	0.338			NA											3	42					0	0	0.004672	0	0
PSMD14	10213	broad.mit.edu	37	2	162242025	162242025	+	Silent	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:162242025A>C	uc002ubu.2	+	8	980	c.513A>C	c.(511-513)GGA>GGC	p.G171G		NM_005805	NP_005796	O00487	PSDE_HUMAN	proteasome 26S subunit, non-ATPase 14	171					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1						TGGTCTTAGGACATGAACCAA	0.318			NA											7	24					0	0	0.00308	0	0
IFIH1	64135	broad.mit.edu	37	2	163124634	163124634	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:163124634C>G	uc002uce.2	-	14	2992	c.2770G>C	c.(2770-2772)GAG>CAG	p.E924Q		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	924					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						TGCATTTTCTCAATTACATGG	0.388			NA											6	41					0	0	0.001168	0	0
SCN1A	6323	broad.mit.edu	37	2	166930121	166930121	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:166930121G>A	uc010zcz.1	-	1	29	c.11C>T	c.(10-12)ACA>ATA	p.T4I		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	4						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TACAAGCACTGTTTGCTCCAT	0.383			NA											25	85					0	0	0.005443	0	0
TTN	7273	broad.mit.edu	37	2	179452360	179452360	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:179452360C>G	uc010zfg.1	-	255	56196	c.55972G>C	c.(55972-55974)GAC>CAC	p.D18658H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D12353H|TTN_uc010zfi.1_Missense_Mutation_p.D12286H|TTN_uc010zfj.1_Missense_Mutation_p.D12161H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19585							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCATAGTGTCAACCAGATCA	0.453			NA											8	40					0	0	0.004482	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187703872	187703872	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:187703872T>C	uc002upu.1	-	4	348	c.308A>G	c.(307-309)GAA>GGA	p.E103G		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	103					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TATCTCTCTTTCTCCAAGACC	0.403			NA											64	139					0	0	0.01441	0	0
COL5A2	1290	broad.mit.edu	37	2	189931462	189931462	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:189931462C>T	uc002uqk.2	-	22	1723	c.1448G>A	c.(1447-1449)GGG>GAG	p.G483E	COL5A2_uc010frx.2_Intron	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	483					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TACTGGTTCCCCTTTTGGGCC	0.363			NA											49	105					0	0	0.01441	0	0
PLCL1	5334	broad.mit.edu	37	2	198949080	198949080	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:198949080T>C	uc010fsp.2	+	2	1130	c.839T>C	c.(838-840)ATC>ACC	p.I280T	PLCL1_uc002uuv.3_Missense_Mutation_p.I201T	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	280					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GAAGCCAAGATCAGGTTAAAG	0.418			NA											34	37					0	0	0.010818	0	0
AOX1	316	broad.mit.edu	37	2	201515816	201515816	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:201515816G>A	uc002uvx.2	+	26	3068	c.2967G>A	c.(2965-2967)AGG>AGA	p.R989R	AOX1_uc010zhf.1_Silent_p.R545R|AOX1_uc010fsu.2_Silent_p.R355R	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	989					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ACTCCTTGAGGAAAGTTGCTG	0.453			NA											21	134					0	0	0.014323	0	0
ZNF142	7701	broad.mit.edu	37	2	219509702	219509702	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:219509702T>G	uc002vin.2	-	8	1973	c.1537A>C	c.(1537-1539)ATG>CTG	p.M513L	ZNF142_uc002vil.2_Missense_Mutation_p.M474L|ZNF142_uc010fvt.2_Missense_Mutation_p.M350L|ZNF142_uc002vim.2_Missense_Mutation_p.M350L	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	513	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		ACCTCACACATCAGAGACTTG	0.597	Colon(170;867 1942 8995 15834 18053)		NA											26	49					0	0	0.004656	0	0
SPEG	10290	broad.mit.edu	37	2	220327061	220327061	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:220327061C>T	uc010fwg.2	+	8	2658	c.2658C>T	c.(2656-2658)GTC>GTT	p.V886V	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Silent_p.V94V|SPEG_uc002vln.1_Silent_p.V94V|SPEG_uc002vlp.1_Silent_p.V94V|SPEG_uc002vlq.2_Silent_p.V37V	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	886	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCAAGATGTCATCATGAGCA	0.602			NA											3	5					0	0	0.004672	0	0
AP1S3	130340	broad.mit.edu	37	2	224642491	224642492	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:224642491_224642492CC>AA	uc010fwx.1	-	2	250_251	c.98_99GG>TT	c.(97-99)CGG>CTT	p.R33L	AP1S3_uc002vnn.2_Missense_Mutation_p.R33L|AP1S3_uc010fww.2_RNA|AP1S3_uc002vno.2_RNA	NM_001039569	NP_001034658	Q96PC3	AP1S3_HUMAN	adaptor-related protein complex 1, sigma 3	33					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane coat	protein transporter activity				0		Renal(207;0.0112)|Lung NSC(271;0.0186)|all_lung(227;0.0272)		Epithelial(121;7.6e-10)|all cancers(144;3.62e-07)|Lung(261;0.0086)|LUSC - Lung squamous cell carcinoma(224;0.00902)		GAACAATTTCCCGGGTGATCTT	0.401			NA											19	27					0	0	0.004672	0	0
SPHKAP	80309	broad.mit.edu	37	2	228996711	228996711	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:228996711G>A	uc002vpq.2	-	2	170	c.123C>T	c.(121-123)ATC>ATT	p.I41I	SPHKAP_uc002vpp.2_Silent_p.I41I|SPHKAP_uc010zlx.1_Silent_p.I41I	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	41						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TACAGGCTGTGATGGAGTTCC	0.468			NA											26	96					0	0	0.004656	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581085	234581085	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:234581085G>A	uc002vus.2	+	1	542	c.505G>A	c.(505-507)GCC>ACC	p.A169T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.A169T	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	169					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	CGTGGTCTTCGCCAGGGGAAT	0.458			NA											32	201					0	0	0.003271	0	0
ANO7	50636	broad.mit.edu	37	2	242140746	242140746	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:242140746C>T	uc002wax.2	+	7	853	c.750C>T	c.(748-750)TTC>TTT	p.F250F		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	250	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						ACACCTTCTTCACAAGCACCA	0.592			NA											21	36					0	0	0.008871	0	0
D2HGDH	728294	broad.mit.edu	37	2	242690737	242690737	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:242690737G>A	uc002wce.1	+	8	1247	c.1074G>A	c.(1072-1074)CTG>CTA	p.L358L	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Silent_p.L224L|D2HGDH_uc002wcg.1_Intron|D2HGDH_uc002wch.2_Intron|D2HGDH_uc002wci.2_Silent_p.L57L	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	358					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCCACTTCCTGGAGCACGCGC	0.612			NA											21	27					0	0	0.014323	0	0
FAM113A	64773	broad.mit.edu	37	20	2816190	2816190	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:2816190C>A	uc002wgz.1	-	8	1780	c.1283G>T	c.(1282-1284)CGG>CTG	p.R428L	FAM113A_uc002whb.1_Missense_Mutation_p.R279L|FAM113A_uc002wha.1_Missense_Mutation_p.R279L|FAM113A_uc010zqa.1_Missense_Mutation_p.R275L|FAM113A_uc002whc.1_Missense_Mutation_p.R377L	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	428							hydrolase activity|protein binding			ovary(2)	2						GTGTCTGAGCCGCTGCCTGCA	0.622			NA											39	22					1.07121e-22	1.37115e-22	0.006999	1	0
CDS2	8760	broad.mit.edu	37	20	5159590	5159590	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:5159590C>G	uc002wls.2	+	5	774	c.517C>G	c.(517-519)CTC>GTC	p.L173V	CDS2_uc002wlr.1_Missense_Mutation_p.L95V|CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Missense_Mutation_p.L118V|CDS2_uc010zqu.1_Missense_Mutation_p.L53V|CDS2_uc002wlv.2_Missense_Mutation_p.L75V|CDS2_uc010zqv.1_5'UTR	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	173	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						TTCCTTTACTCTCTATCTAAT	0.408			NA											31	49					0	0	0.013726	0	0
OTOR	56914	broad.mit.edu	37	20	16730565	16730565	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:16730565G>T	uc002wpj.2	+	3	317	c.273G>T	c.(271-273)CAG>CAT	p.Q91H	OTOR_uc002wpk.2_RNA	NM_020157	NP_064542	Q9NRC9	OTOR_HUMAN	otoraplin precursor	91	SH3.				sensory perception of sound	extracellular region				ovary(1)|central_nervous_system(1)	2						GTGATGGCCAGGACGAGATGG	0.358			NA											5	25					0.00116845	0.00127467	0.001168	1	0
TM9SF4	9777	broad.mit.edu	37	20	30720911	30720911	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:30720911C>T	uc002wxj.2	+	2	346	c.111C>T	c.(109-111)AAC>AAT	p.N37N	TM9SF4_uc010ztr.1_Translation_Start_Site|TM9SF4_uc010zts.1_Translation_Start_Site|TM9SF4_uc002wxk.2_Silent_p.N20N	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	37						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCCACCAGAACGATCCCGTAG	0.517			NA											5	56					0	0	0.000602	0	0
GHRH	2691	broad.mit.edu	37	20	35885254	35885254	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:35885254G>A	uc002xgr.2	-	1	39	c.39C>T	c.(37-39)CTC>CTT	p.L13L	GHRH_uc002xgs.2_Silent_p.L13L|GHRH_uc002xgt.2_Silent_p.L13L	NM_021081	NP_066567	P01286	SLIB_HUMAN	growth hormone releasing hormone preproprotein	13					activation of adenylate cyclase activity by G-protein signaling pathway|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to food	extracellular space|terminal button	growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding			ovary(1)	1		Myeloproliferative disorder(115;0.00878)				AGCTGTTGCTGAGGGTGAGGA	0.612			NA											6	31					0	0	0.00308	0	0
JPH2	57158	broad.mit.edu	37	20	42788372	42788372	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:42788372C>A	uc002xli.1	-	2	1928	c.1055G>T	c.(1054-1056)CGC>CTC	p.R352L		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	352	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CAGCATGCGGCGCTTGGTGTC	0.667			NA											15	40					6.49762e-13	7.89584e-13	0.006122	1	0
UBE2C	11065	broad.mit.edu	37	20	44444383	44444383	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:44444383A>G	uc002xpm.2	+	4	500	c.420A>G	c.(418-420)GGA>GGG	p.G140G	UBE2C_uc002xpl.2_Intron|UBE2C_uc002xpn.2_Silent_p.G101G|UBE2C_uc002xpo.2_Silent_p.G111G|UBE2C_uc002xpp.2_Intron|UBE2C_uc002xpq.2_Silent_p.G101G	NM_007019	NP_008950	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C isoform 1	140					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Myeloproliferative disorder(115;0.0122)				GCCTTCTAGGAGGTGACTTTA	0.542			NA											13	83					0	0	0.013537	0	0
MC3R	4159	broad.mit.edu	37	20	54823932	54823932	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:54823932G>A	uc002xxb.2	+	1	145	c.33G>A	c.(31-33)CAG>CAA	p.Q11Q		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	48	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			CCTCTGTTCAGCCAACACTGC	0.587			NA											81	168					0	0	0.01441	0	0
Unknown	0	broad.mit.edu	37	20	56063817	56063817	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:56063817G>C	uc010zzl.1	-	1	267	c.267C>G	c.(265-267)TTC>TTG	p.F89L		NM_001008735	NP_001008735			high-mobility group box 1-like 1												NA						TGGGATCCTTGAACTTCTTTT	0.453			NA											29	88					0	0	0.008361	0	0
ZNF831	128611	broad.mit.edu	37	20	57767550	57767550	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:57767550C>G	uc002yan.2	+	1	1476	c.1476C>G	c.(1474-1476)CTC>CTG	p.L492L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	492						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCACTCAGCTCTCCACCACCG	0.701			NA											24	59					0	0	0.00333	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692174	31692174	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:31692174G>A	uc002ynw.2	-	1	434	c.180C>T	c.(178-180)TGC>TGT	p.C60C		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	60						intermediate filament				ovary(1)	1						TTGGTTCACCGCAGGTCTCTT	0.567			NA											38	53					0	0	0.007835	0	0
DONSON	29980	broad.mit.edu	37	21	34951771	34951771	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:34951771G>A	uc002ysk.2	-	9	1515	c.1448C>T	c.(1447-1449)TCA>TTA	p.S483L	DONSON_uc002ysi.1_Missense_Mutation_p.S243L|DONSON_uc002ysj.2_Missense_Mutation_p.S116L|DONSON_uc002ysl.2_Missense_Mutation_p.S116L|DONSON_uc010gme.2_Missense_Mutation_p.S456L|DONSON_uc002ysm.2_Missense_Mutation_p.S483L	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	483					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						CATGGTCAGTGAATGCAGAGA	0.448			NA											7	39					0	0	0.001984	0	0
PRDM15	63977	broad.mit.edu	37	21	43280475	43280475	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:43280475C>G	uc002yzq.1	-	8	1009	c.898G>C	c.(898-900)GAG>CAG	p.E300Q	PRDM15_uc002yzo.2_Missense_Mutation_p.E37Q|PRDM15_uc002yzp.2_Missense_Mutation_p.E37Q|PRDM15_uc002yzr.1_Missense_Mutation_p.E37Q	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCAGCCATCTCTGACACCTGT	0.378			NA											25	17					0	0	0.008361	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	45999772	45999772	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:45999772T>C	uc002zfl.1	-	1	710	c.684A>G	c.(682-684)ATA>ATG	p.I228M	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	228	22 X 5 AA repeats of C-C-X(3).					keratin filament					0						CGGGCCTGCATATGGGGCGGC	0.677			NA											3	87					0	0	0.004672	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	45999774	45999774	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:45999774T>C	uc002zfl.1	-	1	708	c.682A>G	c.(682-684)ATA>GTA	p.I228V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	228	22 X 5 AA repeats of C-C-X(3).					keratin filament					0						GGCCTGCATATGGGGCGGCAG	0.682			NA											3	91					0	0	0.004672	0	0
PCNT	5116	broad.mit.edu	37	21	47786839	47786839	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:47786839G>A	uc002zji.3	+	15	3057	c.2950G>A	c.(2950-2952)GAG>AAG	p.E984K	PCNT_uc002zjj.2_Missense_Mutation_p.E866K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	984					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GACCATCCGTGAGGAGCACAG	0.502			NA											40	111					0	0	0.00623	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072541	17072541	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:17072541G>A	uc002zlp.1	-	1	1160	c.900C>T	c.(898-900)GAC>GAT	p.D300D		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	300					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGGTCTCCTCGTCGACCTCCC	0.493			NA											65	157					0	0	0.01441	0	0
GAB4	128954	broad.mit.edu	37	22	17472947	17472947	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:17472947G>A	uc002zlw.2	-	2	402	c.294C>T	c.(292-294)CTC>CTT	p.L98L	GAB4_uc010gqs.1_Silent_p.L98L	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	98	PH.									large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGCTCACAGAGGTTCAGGT	0.488			NA											86	166					0	0	0.01441	0	0
HPS4	89781	broad.mit.edu	37	22	26861450	26861450	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:26861450G>A	uc003acl.2	-	10	1433	c.774C>T	c.(772-774)CTC>CTT	p.L258L	HPS4_uc003aci.2_Silent_p.L253L|HPS4_uc003acj.2_Silent_p.L122L|HPS4_uc003ack.2_Silent_p.L49L|HPS4_uc003acn.2_Silent_p.L104L|HPS4_uc010gvd.1_Silent_p.L276L|HPS4_uc003ach.2_5'UTR	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	258					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GGAACTCGTGGAGACTAATGG	0.488			NA							Hermansky-Pudlak_syndrome				12	52					0	0	0.013537	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120013	38120013	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:38120013C>T	uc003atr.2	+	7	1721	c.1450C>T	c.(1450-1452)CGG>TGG	p.R484W	TRIOBP_uc003atu.2_Missense_Mutation_p.R312W|TRIOBP_uc003atq.1_Missense_Mutation_p.R484W|TRIOBP_uc003ats.1_Missense_Mutation_p.R312W	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	484					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTGTGCCCAGCGGGACAATCC	0.602			NA											30	110					0	0	0.004878	0	0
PICK1	9463	broad.mit.edu	37	22	38466861	38466861	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:38466861G>T	uc003auq.2	+	7	846	c.456G>T	c.(454-456)AGG>AGT	p.R152S	PICK1_uc003aur.2_Missense_Mutation_p.R152S|PICK1_uc003aus.2_Missense_Mutation_p.R152S|PICK1_uc003aut.2_Missense_Mutation_p.R152S	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	152	AH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					TTGTCAAGAGGCTAGAGGAGC	0.627			NA											10	32					0.000673444	0.000736759	0.008291	1	0
PNPLA3	80339	broad.mit.edu	37	22	44322984	44322984	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:44322984C>T	uc003bei.1	+	2	530	c.357C>T	c.(355-357)ACC>ACT	p.T119T	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	119	Lumenal (Potential).|Patatin.				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				TCTCTCTTACCAGAGTGTCTG	0.493			NA											20	46					0	0	0.014323	0	0
FANCD2	2177	broad.mit.edu	37	3	10136010	10136010	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:10136010G>T	uc003buw.2	+	40	4004	c.3926G>T	c.(3925-3927)TGT>TTT	p.C1309F	FANCD2_uc003bux.1_Missense_Mutation_p.C1309F|FANCD2_uc003buy.1_Missense_Mutation_p.C1309F|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1309					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CTGAAGCAATGTATGCCGCTC	0.458			NA	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				111	153					3.21225e-43	4.15321e-43	0.01441	1	0
OXNAD1	92106	broad.mit.edu	37	3	16336367	16336367	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:16336367G>T	uc003caw.2	+	6	752	c.295G>T	c.(295-297)GAT>TAT	p.D99Y	OXNAD1_uc010her.1_RNA|OXNAD1_uc003cax.2_Missense_Mutation_p.D99Y|OXNAD1_uc011awb.1_Missense_Mutation_p.D117Y	NM_138381	NP_612390	Q96HP4	OXND1_HUMAN	oxidoreductase NAD-binding domain containing 1	99	FAD-binding FR-type.						oxidoreductase activity			skin(1)	1						TTTTAGGGTTGATTTCTTTAT	0.274			NA											19	37					5.03518e-11	6.0234e-11	0.007413	1	0
THRB	7068	broad.mit.edu	37	3	24174828	24174828	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:24174828T>C	uc003ccx.3	-	9	1213	c.864A>G	c.(862-864)AAA>AAG	p.K288K	THRB_uc010hfe.2_Silent_p.K288K|THRB_uc003ccy.3_Silent_p.K288K|THRB_uc003ccz.3_Silent_p.K283K	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	288	Ligand-binding.|Interaction with NR2F6.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	TAGGCAACTTTTTGGCAAAAT	0.383	Melanoma(21;896 1043 15021 37958)		NA											4	28					0	0	0.009096	0	0
ZNF860	344787	broad.mit.edu	37	3	32031784	32031784	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:32031784A>G	uc011axg.1	+	2	1762	c.1213A>G	c.(1213-1215)AAA>GAA	p.K405E		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	405	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGATTGTCACAAAGTCTTCAG	0.363			NA											5	32					0	0	0.001984	0	0
MLH1	4292	broad.mit.edu	37	3	37053345	37053345	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:37053345G>A	uc003cgl.2	+	7	640	c.580G>A	c.(580-582)GTT>ATT	p.V194I	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Missense_Mutation_p.V194I|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_Missense_Mutation_p.V96I|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR|MLH1_uc010hgg.1_5'Flank|MLH1_uc010hgh.1_5'Flank|MLH1_uc010hgi.1_5'Flank|MLH1_uc010hgj.1_5'Flank|MLH1_uc010hgk.2_5'Flank|MLH1_uc010hgl.1_5'Flank	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	194					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TAGTTTCTCAGTTAAAAAAGT	0.353			1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				27	121					0	0	0.008361	0	0
DOCK3	1795	broad.mit.edu	37	3	51198034	51198034	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:51198034A>G	uc011bds.1	+	12	961	c.938A>G	c.(937-939)TAC>TGC	p.Y313C		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	313						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CACCTGCACTACAGGCGACCA	0.493			NA											9	10					0	0	0.004482	0	0
PTPRG	5793	broad.mit.edu	37	3	62240846	62240846	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:62240846G>A	uc003dlb.2	+	16	3234	c.2515G>A	c.(2515-2517)GAG>AAG	p.E839K	PTPRG_uc003dlc.2_Missense_Mutation_p.E810K|PTPRG_uc011bfi.1_Missense_Mutation_p.E85K	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	839	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ACACATCGGTGAGCTCTATTC	0.373			NA											24	39					0	0	0.008361	0	0
PROS1	5627	broad.mit.edu	37	3	93615521	93615521	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:93615521G>A	uc003drb.3	-	9	1205	c.864C>T	c.(862-864)TGC>TGT	p.C288C	PROS1_uc010hoo.2_Silent_p.C157C|PROS1_uc003dqz.3_Silent_p.C157C	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	288					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TCAAGGGAAGGCACACTGAAA	0.358			NA											40	97					0	0	0.00623	0	0
IGSF11	152404	broad.mit.edu	37	3	118621435	118621435	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:118621435T>A	uc003ebw.2	-	7	1475	c.1228A>T	c.(1228-1230)ACA>TCA	p.T410S	IGSF11_uc011biv.1_Missense_Mutation_p.T382S|IGSF11_uc003ebx.2_Missense_Mutation_p.T386S|IGSF11_uc003eby.2_Missense_Mutation_p.T409S|IGSF11_uc003ebz.2_Missense_Mutation_p.T385S|IGSF11_uc010hqs.2_Missense_Mutation_p.T409S	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	410	Cytoplasmic (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CGTTCCAGTGTTGCGTGGCTG	0.527			NA											38	70					0	0	0.00623	0	0
A4GNT	51146	broad.mit.edu	37	3	137843425	137843425	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:137843425C>G	uc003ers.2	-	3	906	c.704G>C	c.(703-705)TGG>TCG	p.W235S		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	235	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						AAGTTTACACCATACCCTCAA	0.463			NA											24	56					0	0	0.014323	0	0
PRR23C	389152	broad.mit.edu	37	3	138762903	138762903	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:138762903C>T	uc011bmt.1	-	1	832	c.560G>A	c.(559-561)AGC>AAC	p.S187N		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	187										skin(1)	1						CCGGTAGGGGCTGAACATACT	0.652			NA											7	16					0	0	0.001984	0	0
RTP1	132112	broad.mit.edu	37	3	186917551	186917551	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:186917551G>T	uc003frg.2	+	2	515	c.485G>T	c.(484-486)CGC>CTC	p.R162L		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	162	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		ACCAGCCTGCGCGAGCAGTGC	0.677			NA											25	12					6.07407e-21	7.69784e-21	0.007291	1	0
PDE6B	5158	broad.mit.edu	37	4	654380	654380	+	Missense_Mutation	SNP	G	G	A	rs144664551		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:654380G>A	uc003gap.2	+	12	1645	c.1592G>A	c.(1591-1593)CGA>CAA	p.R531Q	PDE6B_uc003gao.3_Missense_Mutation_p.R531Q|PDE6B_uc011buy.1_Missense_Mutation_p.R252Q	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	531					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GGCGTGGTCCGAAAGTTCCAG	0.587	GBM(71;463 1194 9848 25922 46834)		NA											5	26					0	0	0.001984	0	0
BOD1L	259282	broad.mit.edu	37	4	13603329	13603329	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:13603329G>C	uc003gmz.1	-	10	5312	c.5195C>G	c.(5194-5196)GCA>GGA	p.A1732G	BOD1L_uc010idr.1_Missense_Mutation_p.A1069G	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1732							DNA binding			ovary(5)|breast(1)	6						TCTGCCTTCTGCTCCTGTACA	0.502			NA											26	119					0	0	0.00333	0	0
ANAPC4	29945	broad.mit.edu	37	4	25394003	25394003	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:25394003G>A	uc003gro.2	+	10	878	c.749G>A	c.(748-750)CGG>CAG	p.R250Q	ANAPC4_uc003grp.2_Missense_Mutation_p.R135Q|ANAPC4_uc010iet.1_Missense_Mutation_p.R59Q|ANAPC4_uc010ieu.1_Missense_Mutation_p.R59Q	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	250					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				GAAGTAACTCGGATGGCCAGA	0.343			NA											11	52					0	0	0.001855	0	0
PCDH7	5099	broad.mit.edu	37	4	30725930	30725930	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:30725930G>A	uc003gsk.1	+	1	3894	c.2886G>A	c.(2884-2886)CAG>CAA	p.Q962Q	PCDH7_uc011bxw.1_Silent_p.Q915Q|PCDH7_uc011bxx.1_Silent_p.Q962Q	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	962	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.P962P(1)		upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CAAATGGACAGAGGTATGATA	0.473			NA											14	74					0	0	0.00499	0	0
ATP10D	57205	broad.mit.edu	37	4	47514737	47514737	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:47514737C>G	uc003gxk.1	+	2	344	c.180C>G	c.(178-180)TTC>TTG	p.F60L	ATP10D_uc003gxj.3_Missense_Mutation_p.F60L	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	60	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TCCAGCCCTTCAAGGATGAGT	0.463			NA											11	50					0	0	0.010729	0	0
SGCB	6443	broad.mit.edu	37	4	52890175	52890175	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:52890175C>A	uc003gzj.2	-	6	965	c.905G>T	c.(904-906)AGC>ATC	p.S302I	SGCB_uc011bzp.1_Missense_Mutation_p.S232I	NM_000232	NP_000223	Q16585	SGCB_HUMAN	sarcoglycan, beta	302	Extracellular (Potential).|Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma					0			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CATGTTCTGGCTGGTTACTTG	0.493			NA											18	34					1.56452e-12	1.88924e-12	0.007413	1	0
LPHN3	23284	broad.mit.edu	37	4	62758580	62758580	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:62758580G>A	uc010ihh.2	+	7	1656	c.1483G>A	c.(1483-1485)GAA>AAA	p.E495K	LPHN3_uc003hcq.3_Missense_Mutation_p.E495K|LPHN3_uc003hcs.1_Missense_Mutation_p.E324K	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	495	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCCAGCTCTCGAAGAGAGCTG	0.502			NA											5	19					0	0	0.001168	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978250	69978250	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:69978250C>T	uc003heg.3	+	6	1432	c.1386C>T	c.(1384-1386)TTC>TTT	p.F462F	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	462					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GAGCAGTCTTCTGGATTGAAT	0.423			NA											26	83					0	0	0.00632	0	0
BMP2K	55589	broad.mit.edu	37	4	79792085	79792085	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:79792085G>C	uc003hlk.2	+	11	1546	c.1380G>C	c.(1378-1380)CAG>CAC	p.Q460H	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.Q460H|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	460	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						ATCCTCACcagcagcagcagc	0.254			NA											6	278					0	0	0.00308	0	0
PDLIM5	10611	broad.mit.edu	37	4	95444920	95444920	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:95444920G>T	uc003hti.2	+	3	293	c.142G>T	c.(142-144)GAT>TAT	p.D48Y	PDLIM5_uc003htf.2_Missense_Mutation_p.D48Y|PDLIM5_uc003htg.2_Missense_Mutation_p.D48Y|PDLIM5_uc011cdx.1_Missense_Mutation_p.D48Y|PDLIM5_uc003hth.2_Missense_Mutation_p.D48Y|PDLIM5_uc003htj.2_5'UTR|PDLIM5_uc003htk.2_Missense_Mutation_p.D48Y|PDLIM5_uc011cdy.1_Intron	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	48	PDZ.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		AAGAATAGGCGATGTGGTTCT	0.378			NA											10	15					4.68919e-08	5.44003e-08	0.008291	1	0
GLRA3	8001	broad.mit.edu	37	4	175598396	175598396	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:175598396C>T	uc003ity.1	-	7	1263	c.760G>A	c.(760-762)GGA>AGA	p.G254R	GLRA3_uc003itz.1_Missense_Mutation_p.G254R	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	254	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	AGATAGTATCCCATTTGTCGC	0.428			NA											7	28					0	0	0.00308	0	0
PRDM9	56979	broad.mit.edu	37	5	23524634	23524634	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:23524634G>A	uc003jgo.2	+	10	1324	c.1142G>A	c.(1141-1143)AGA>AAA	p.R381K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	381				Missing (in Ref. 4; AAF87242).	meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATGGCAGGGAGAGGTAGGCAT	0.448			NA								HNSCC(3;0.000094)			15	50					0	0	0.00278	0	0
SKP2	6502	broad.mit.edu	37	5	36166718	36166718	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:36166718C>T	uc003jkc.1	+	4	672	c.490C>T	c.(490-492)CGC>TGC	p.R164C	SKP2_uc011cou.1_5'UTR|SKP2_uc003jkd.2_Missense_Mutation_p.R164C	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	164	LRR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATTGCCTTCCGCTGCCCACG	0.453			NA											15	45					0	0	0.00499	0	0
WDR70	55100	broad.mit.edu	37	5	37379592	37379592	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:37379592G>A	uc003jkv.2	+	2	85	c.27G>A	c.(25-27)GTG>GTA	p.V9V	WDR70_uc010iva.1_Silent_p.V9V	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	9										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGCTCCAGTGACAGGCTCAG	0.662			NA											31	67					0	0	0.010818	0	0
DAB2	1601	broad.mit.edu	37	5	39394407	39394407	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:39394407C>A	uc003jlx.2	-	2	547	c.16G>T	c.(16-18)GAA>TAA	p.E6*	DAB2_uc003jlw.2_Nonsense_Mutation_p.E6*	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	6					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			GCACTTGTTTCTACTTCGTTA	0.483			NA											20	55					5.26018e-13	6.41241e-13	0.012319	1	0
HMGCS1	3157	broad.mit.edu	37	5	43299040	43299040	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:43299040C>T	uc003jnr.3	-	3	235	c.28G>A	c.(28-30)GAA>AAA	p.E10K	HMGCS1_uc003jnq.3_Missense_Mutation_p.E10K	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	10					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						CAGCAAGCTTCTGCATTCAAA	0.373			NA											12	50					0	0	0.013537	0	0
ACSL6	23305	broad.mit.edu	37	5	131308521	131308521	+	Missense_Mutation	SNP	G	G	A	rs140341663	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:131308521G>A	uc010jdo.1	-	13	1242	c.1159C>T	c.(1159-1161)CGC>TGC	p.R387C	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.R412C|ACSL6_uc003kvy.1_Missense_Mutation_p.R412C|ACSL6_uc003kwb.2_Missense_Mutation_p.R377C|ACSL6_uc003kvz.1_Missense_Mutation_p.R312C|ACSL6_uc003kwa.1_Missense_Mutation_p.R398C|ACSL6_uc003kvw.1_Missense_Mutation_p.R33C|ACSL6_uc010jdn.1_Missense_Mutation_p.R402C	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	387	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGAGCCAGCGCTTTAATGGT	0.458			NA											23	41					0	0	0.00278	0	0
IL13	3596	broad.mit.edu	37	5	131995955	131995955	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:131995955G>A	uc003kxj.1	+	4	436	c.422G>A	c.(421-423)CGC>CAC	p.R141H		NM_002188	NP_002179	P35225	IL13_HUMAN	interleukin 13 precursor	141					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			ovary(1)|skin(1)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAACTTTTTCGCGAGGGACAG	0.413			NA											4	28					0	0	0.001168	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581426	140581426	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:140581426G>A	uc003liy.2	+	1	2079	c.2079G>A	c.(2077-2079)GCG>GCA	p.A693A	PCDHB11_uc011daj.1_Silent_p.A328A	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	693	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGGTGGCGTTGGCCTCGG	0.692			NA											89	114					0	0	0.01441	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711485	140711485	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:140711485A>T	uc003lji.1	+	1	1234	c.1234A>T	c.(1234-1236)AGA>TGA	p.R412*	PCDHGA1_uc011dan.1_Nonsense_Mutation_p.R412*	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	412	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACTGGACAGAGAACTTAT	0.368			NA											24	34					0	0	0.003954	0	0
FAT2	2196	broad.mit.edu	37	5	150923577	150923577	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:150923577C>G	uc003lue.3	-	9	7124	c.7111G>C	c.(7111-7113)GAT>CAT	p.D2371H	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2371	Extracellular (Potential).|Cadherin 20.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCATTGATATCAGACACATTG	0.468			NA											20	60					0	0	0.010504	0	0
WWC1	23286	broad.mit.edu	37	5	167826495	167826495	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:167826495C>T	uc003lzu.2	+	5	606	c.513C>T	c.(511-513)GTC>GTT	p.V171V	WWC1_uc003lzv.2_Silent_p.V171V|WWC1_uc011den.1_Silent_p.V171V	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	171	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CCCTCCAGGTCAACAAGCTGA	0.577			NA											9	29					0	0	0.006214	0	0
HRH2	3274	broad.mit.edu	37	5	175110317	175110317	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:175110317C>T	uc003mdd.2	+	1	1854	c.81C>T	c.(79-81)GTC>GTT	p.V27V	HRH2_uc003mdc.3_Silent_p.V27V	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	27	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	TCCTTGCGGTCCTCATCCTCA	0.582			NA											71	128					0	0	0.01441	0	0
AGXT2L2	85007	broad.mit.edu	37	5	177642318	177642318	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:177642318G>A	uc003miz.2	-	9	1293	c.1041C>T	c.(1039-1041)CTC>CTT	p.L347L	AGXT2L2_uc003miy.2_Silent_p.L72L|AGXT2L2_uc003mjc.2_Silent_p.L306L|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_Silent_p.L72L|AGXT2L2_uc003mjd.1_Silent_p.L205L	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	347						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTGCTGCCCGAGGAGCTGCA	0.577			NA											14	19					0	0	0.003163	0	0
ZNF184	7738	broad.mit.edu	37	6	27420788	27420788	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:27420788C>A	uc003njj.2	-	5	1361	c.550G>T	c.(550-552)GGG>TGG	p.G184W	ZNF184_uc010jqv.2_Missense_Mutation_p.G184W|ZNF184_uc003nji.2_Missense_Mutation_p.G184W	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACACTTTTCCCAAATTCATTA	0.398			NA											21	146					1.9806e-07	2.2771e-07	0.014323	1	0
OR2H2	7932	broad.mit.edu	37	6	29556415	29556415	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:29556415C>T	uc003nmr.1	+	1	733	c.694C>T	c.(694-696)CGG>TGG	p.R232W	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	232	Cytoplasmic (Potential).			KGR -> TAW (in Ref. 1; AAB36567).	defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAAAAGGGCGGAGGAAAGC	0.522			NA											10	85					0	0	0.006214	0	0
EYS	346007	broad.mit.edu	37	6	66112465	66112465	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:66112465C>A	uc011dxu.1	-	7	1628	c.1090G>T	c.(1090-1092)GAT>TAT	p.D364Y	EYS_uc003peq.2_Missense_Mutation_p.D364Y|EYS_uc003per.1_Missense_Mutation_p.D364Y	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	364	EGF-like 4.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CAAAGCAAATCTGTAAATATT	0.303			NA											16	29					4.7546e-09	5.58339e-09	0.004007	1	0
SNX14	57231	broad.mit.edu	37	6	86227558	86227558	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:86227558G>A	uc003pkr.2	-	23	2377	c.2184C>T	c.(2182-2184)TTC>TTT	p.F728F	SNX14_uc003pkp.2_Silent_p.F591F|SNX14_uc003pkq.2_Silent_p.F334F|SNX14_uc011dzg.1_Silent_p.F676F|SNX14_uc003pks.2_Silent_p.F675F|SNX14_uc003pkt.2_Silent_p.F719F	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	728					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		AAGAATTAATGAAATTCATGA	0.343			NA											5	36					0	0	0.000602	0	0
ZNF292	23036	broad.mit.edu	37	6	87966229	87966229	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:87966229G>A	uc003plm.3	+	8	2923	c.2882G>A	c.(2881-2883)GGC>GAC	p.G961D		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	961					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACTGTGGAAGGCAGTGGTGAA	0.433			NA											20	47					0	0	0.010504	0	0
FBXL4	26235	broad.mit.edu	37	6	99323402	99323402	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:99323402G>A	uc003ppf.1	-	8	1949	c.1591C>T	c.(1591-1593)CAG>TAG	p.Q531*	FBXL4_uc003ppg.1_Nonsense_Mutation_p.Q531*|FBXL4_uc003pph.1_Nonsense_Mutation_p.Q133*|FBXL4_uc010kcp.2_Nonsense_Mutation_p.Q109*	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	531					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		TTTGGGAGCTGGTGTGCCAGT	0.502			NA											4	44					0	0	0.009096	0	0
LIN28B	389421	broad.mit.edu	37	6	105406144	105406144	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:105406144G>A	uc003pqv.1	+	2	384	c.181G>A	c.(181-183)GAT>AAT	p.D61N	LIN28B_uc010kda.1_Missense_Mutation_p.D21N	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	61	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				TATTCCAGTCGATGTATTTGT	0.458			NA											6	66					0	0	0.001984	0	0
PRDM1	639	broad.mit.edu	37	6	106554835	106554835	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:106554835G>C	uc003prd.2	+	7	2186	c.1952G>C	c.(1951-1953)CGA>CCA	p.R651P	PRDM1_uc003pre.2_Missense_Mutation_p.R517P	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	651	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACCCACCTGCGACTCCATTCT	0.547			NA	D|N|Mis|F|S		DLBCL								10	79					0	0	0.00245	0	0
EYA4	2070	broad.mit.edu	37	6	133777745	133777745	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:133777745C>A	uc003qec.3	+	6	787	c.329C>A	c.(328-330)GCC>GAC	p.A110D	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Missense_Mutation_p.A110D|EYA4_uc003qee.3_Missense_Mutation_p.A87D|EYA4_uc011ecs.1_Missense_Mutation_p.A110D|uc003qef.1_RNA	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	110					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GAAACCACAGCCACGACTGGA	0.458	Melanoma(57;398 1237 3528 4702 7415)		NA											12	135					1.52009e-12	1.84137e-12	0.003163	1	0
LPA	4018	broad.mit.edu	37	6	161071369	161071369	+	Splice_Site	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:161071369C>T	uc003qtl.2	-	3	329	c.209_splice	c.e3+1	p.A70_splice		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TAATGACATACGCATTTGGGT	0.403			NA											64	100					0	0	0.01441	0	0
SNX13	23161	broad.mit.edu	37	7	17931175	17931175	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:17931175G>A	uc003stw.1	-	4	525	c.312C>T	c.(310-312)CTC>CTT	p.L104L	SNX13_uc003stv.2_Silent_p.L104L|SNX13_uc010kuc.2_5'UTR|SNX13_uc003stx.1_Silent_p.L24L|SNX13_uc003sty.2_Silent_p.L104L			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	104	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					TCACTTGCTGGAGAGGTTCAT	0.338			NA											17	41					0	0	0.006122	0	0
HECW1	23072	broad.mit.edu	37	7	43506115	43506115	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:43506115C>T	uc003tid.1	+	15	3466	c.2861C>T	c.(2860-2862)GCG>GTG	p.A954V	HECW1_uc011kbi.1_Missense_Mutation_p.A920V	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	954					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGTCCCCAGCGGTCAAGTTC	0.498			NA											29	55					0	0	0.007291	0	0
ADCY1	107	broad.mit.edu	37	7	45697356	45697356	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:45697356G>C	uc003tne.3	+	6	1197	c.1179G>C	c.(1177-1179)CTG>CTC	p.L393L	ADCY1_uc003tnd.2_Silent_p.L168L	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	393	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGGTGGATCTGAACATGCGTG	0.612			NA											5	17					0	0	0.000602	0	0
ZNF716	441234	broad.mit.edu	37	7	57528802	57528802	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:57528802C>A	uc011kdi.1	+	4	747	c.635C>A	c.(634-636)TCT>TAT	p.S212Y		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AGGGAGAAGTCTTACAAATGT	0.358			NA											7	13					0.00198382	0.00214588	0.001984	1	0
AKAP9	10142	broad.mit.edu	37	7	91694636	91694636	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:91694636G>A	uc003ulg.2	+	25	6294	c.6069G>A	c.(6067-6069)GTG>GTA	p.V2023V	AKAP9_uc003ulf.2_Silent_p.V2023V|AKAP9_uc003uli.2_Silent_p.V1646V	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2035	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAACAAGTGAAAGCTCTAG	0.328			NA	T	BRAF	papillary thyroid								6	22					0	0	0.001168	0	0
KRIT1	889	broad.mit.edu	37	7	91851243	91851243	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:91851243C>T	uc003ulq.1	-	12	1707	c.1536G>A	c.(1534-1536)GTG>GTA	p.V512V	KRIT1_uc010lev.1_Silent_p.V269V|KRIT1_uc003ulr.1_Silent_p.V512V|KRIT1_uc003uls.1_Silent_p.V512V|KRIT1_uc003ult.1_Silent_p.V464V|KRIT1_uc003ulu.1_Silent_p.V512V|KRIT1_uc003ulv.1_Silent_p.V512V	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	512	Required for RAP1A binding.|FERM.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGGGAAGTCTCACATCTCTTC	0.378			NA							Familial_Cerebral_Cavernous_Angioma				83	94					0	0	0.01441	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763666	92763666	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:92763666C>A	uc003umh.1	-	5	2835	c.1619G>T	c.(1618-1620)AGA>ATA	p.R540I	SAMD9L_uc003umj.1_Missense_Mutation_p.R540I|SAMD9L_uc003umi.1_Missense_Mutation_p.R540I|SAMD9L_uc010lfb.1_Missense_Mutation_p.R540I|SAMD9L_uc003umk.1_Missense_Mutation_p.R540I|SAMD9L_uc010lfc.1_Missense_Mutation_p.R540I|SAMD9L_uc010lfd.1_Missense_Mutation_p.R540I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	540										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AAATTTTCCTCTTGTCATTAT	0.368			NA											7	134					0.00198382	0.00214588	0.001984	1	0
SGCE	8910	broad.mit.edu	37	7	94228233	94228233	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:94228233C>G	uc003unl.2	-	9	1218	c.1107G>C	c.(1105-1107)AAG>AAC	p.K369N	SGCE_uc003unk.2_Missense_Mutation_p.K192N|SGCE_uc003unm.2_Missense_Mutation_p.K369N|SGCE_uc003unn.2_Missense_Mutation_p.K360N|SGCE_uc011kic.1_Missense_Mutation_p.K328N|SGCE_uc011kid.1_Missense_Mutation_p.K405N	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	369	Cytoplasmic (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CTCGAAGCTCCTTGGTAGATT	0.418			NA											17	164					0	0	0.00499	0	0
ASB4	51666	broad.mit.edu	37	7	95125216	95125216	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:95125216C>A	uc011kij.1	+	2	334	c.334C>A	c.(334-336)CAC>AAC	p.H112N	ASB4_uc003unx.2_Missense_Mutation_p.H112N	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	112	ANK 2.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			AACCCCTCTTCACGTGGCTTG	0.478			NA											24	201					3.28513e-13	4.01748e-13	0.003954	1	0
TRRAP	8295	broad.mit.edu	37	7	98586403	98586403	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:98586403C>G	uc003upp.2	+	62	9626	c.9417C>G	c.(9415-9417)AAC>AAG	p.N3139K	TRRAP_uc011kis.1_Missense_Mutation_p.N3110K|TRRAP_uc003upr.2_Missense_Mutation_p.N2827K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3139	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGGCAAACAAAGCCTTCT	0.408			NA											9	155					0	0	0.004482	0	0
TRIM4	89122	broad.mit.edu	37	7	99490035	99490035	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:99490035C>A	uc003usd.2	-	7	1384	c.1254G>T	c.(1252-1254)GCG>GCT	p.A418A	TRIM4_uc003use.2_Silent_p.A392A|TRIM4_uc011kjc.1_Silent_p.A248A	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	418	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				TCCAATAAATCGCCCAGATGC	0.542			NA											69	844					2.94884e-30	3.78714e-30	0.01441	1	0
CFTR	1080	broad.mit.edu	37	7	117171025	117171025	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:117171025G>A	uc003vjd.2	+	4	478	c.346G>A	c.(346-348)GAA>AAA	p.E116K	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	116	ABC transmembrane type-1 1.|Extracellular (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TAACAAGGAGGAACGCTCTAT	0.448			NA							Cystic_Fibrosis				8	205					0	0	0.00308	0	0
AASS	10157	broad.mit.edu	37	7	121726194	121726194	+	Missense_Mutation	SNP	C	C	T	rs117830956	by1000genomes	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:121726194C>T	uc003vka.2	-	18	2152	c.2056G>A	c.(2056-2058)GTT>ATT	p.V686I	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.V686I|AASS_uc011knw.1_Missense_Mutation_p.V174I	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	686	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATGGACGTAACGGCATCAAGA	0.428			NA											4	39					0	0	0.009096	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919577	142919577	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:142919577A>T	uc011ksx.1	+	1	406	c.406A>T	c.(406-408)AGG>TGG	p.R136W		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	136	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					CCTGATGAAGAGGAAAATCAT	0.423			NA											47	125					0	0	0.011902	0	0
MLL3	58508	broad.mit.edu	37	7	151927076	151927076	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:151927076C>A	uc003wla.2	-	18	3127	c.2908G>T	c.(2908-2910)GCA>TCA	p.A970S	MLL3_uc003wkz.2_Missense_Mutation_p.A31S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	970	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTCCTTCTGCTCCTTGGCCA	0.353	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								11	301					3.99206e-14	4.9133e-14	0.007413	1	0
DPP6	1804	broad.mit.edu	37	7	154659728	154659728	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:154659728G>A	uc003wlk.2	+	18	1867	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K	DPP6_uc003wli.2_Missense_Mutation_p.E516K|DPP6_uc003wlm.2_Missense_Mutation_p.E518K|DPP6_uc011kvq.1_Missense_Mutation_p.E473K	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	580	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGAAACAAATGAACATGTCAA	0.423	NSCLC(125;1384 1783 2490 7422 34254)		NA											4	19					0	0	0.000602	0	0
XKR6	286046	broad.mit.edu	37	8	11058765	11058765	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:11058765G>A	uc003wtk.1	-	1	111	c.84C>T	c.(82-84)GGC>GGT	p.G28G		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	28	Gly-rich.					integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CGTCCTCCTCGCCGCCGCTGC	0.577			NA											4	10					0	0	0.001168	0	0
LZTS1	11178	broad.mit.edu	37	8	20110540	20110540	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:20110540C>T	uc003wzr.2	-	2	1013	c.902G>A	c.(901-903)CGC>CAC	p.R301H	LZTS1_uc010ltg.1_Missense_Mutation_p.R301H	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	301	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GTCCCTGCAGCGCCGCGGCCG	0.682			NA											11	47					0	0	0.008291	0	0
UNC5D	137970	broad.mit.edu	37	8	35579764	35579764	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:35579764G>T	uc003xjr.1	+	9	1482	c.1154G>T	c.(1153-1155)GGC>GTC	p.G385V	UNC5D_uc003xjs.1_Missense_Mutation_p.G380V|UNC5D_uc003xju.1_5'Flank|UNC5D_uc003xjt.1_Missense_Mutation_p.G143V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	385	Helical; (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGTACTCGGGCTTGGGTGCT	0.522			NA											8	157					0.000274275	0.000302648	0.004482	1	0
PRKDC	5591	broad.mit.edu	37	8	48752729	48752729	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:48752729T>C	uc003xqi.2	-	56	7359	c.7302A>G	c.(7300-7302)GTA>GTG	p.V2434V	PRKDC_uc003xqj.2_Silent_p.V2434V|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2434					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTCCAAACATACTTTTTGTC	0.338	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					3	4					0	0	0.004672	0	0
PENK	5179	broad.mit.edu	37	8	57354089	57354089	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:57354089C>G	uc003xsz.2	-	2	627	c.546G>C	c.(544-546)GTG>GTC	p.V182V	PENK_uc003xta.3_Silent_p.V182V	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	182					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			ATCTCTTGCTCACTTCTTCCT	0.517			NA											40	78					0	0	0.00874	0	0
TRPA1	8989	broad.mit.edu	37	8	72975736	72975736	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:72975736G>C	uc003xza.2	-	5	798	c.623C>G	c.(622-624)TCA>TGA	p.S208*		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	208	ANK 5.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TTTGGAACCTGAAAATGCAGC	0.328			NA											22	20					0	0	0.004656	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229783	87229783	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:87229783G>A	uc003ydq.1	-	3	1193	c.1095C>T	c.(1093-1095)TTC>TTT	p.F365F	SLC7A13_uc003ydr.1_Silent_p.F356F	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	365	Helical; Name=10; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						ATGAACCCGTGAAAAAAATAT	0.338			NA											11	26					0	0	0.008291	0	0
UBR5	51366	broad.mit.edu	37	8	103271226	103271226	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:103271226G>T	uc003ykr.1	-	57	8121	c.8088C>A	c.(8086-8088)TTC>TTA	p.F2696L	UBR5_uc003yks.1_Missense_Mutation_p.F2695L|UBR5_uc003ykq.2_Missense_Mutation_p.F207L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2696	HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATTCATCATTGAAAGAGGTAA	0.338	Ovarian(131;96 1741 5634 7352 27489)		NA											12	28					3.07112e-06	3.44827e-06	0.010729	1	0
CSMD3	114788	broad.mit.edu	37	8	113299453	113299453	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:113299453G>A	uc003ynu.2	-	58	9330	c.9171C>T	c.(9169-9171)GGC>GGT	p.G3057G	CSMD3_uc003yns.2_Silent_p.G2259G|CSMD3_uc003ynt.2_Silent_p.G3017G|CSMD3_uc011lhx.1_Silent_p.G2888G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3057	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TACCTGGATCGCCACATGTCC	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	135					0	0	0.00245	0	0
CSMD3	114788	broad.mit.edu	37	8	113318320	113318320	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:113318320G>T	uc003ynu.2	-	51	8146	c.7987C>A	c.(7987-7989)CGA>AGA	p.R2663R	CSMD3_uc003yns.2_Silent_p.R1865R|CSMD3_uc003ynt.2_Silent_p.R2623R|CSMD3_uc011lhx.1_Silent_p.R2559R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2663	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATGACAATCGATATCCATCA	0.418			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			31	76					5.90632e-09	6.8937e-09	0.012213	1	0
CSMD3	114788	broad.mit.edu	37	8	113331153	113331153	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:113331153G>A	uc003ynu.2	-	47	7432	c.7273C>T	c.(7273-7275)CCA>TCA	p.P2425S	CSMD3_uc003yns.2_Missense_Mutation_p.P1627S|CSMD3_uc003ynt.2_Missense_Mutation_p.P2385S|CSMD3_uc011lhx.1_Missense_Mutation_p.P2321S|CSMD3_uc003ynw.1_Missense_Mutation_p.P136S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2425	Extracellular (Potential).|Sushi 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTAAATCCTGGAAGACACTGA	0.358			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	33					0	0	0.009096	0	0
RNF139	11236	broad.mit.edu	37	8	125498769	125498769	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:125498769C>T	uc003yrc.2	+	2	1222	c.879C>T	c.(877-879)GGC>GGT	p.G293G		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	293	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTGTACTGGGCATGAGTGCTG	0.408			NA							Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				11	157					0	0	0.001855	0	0
TG	7038	broad.mit.edu	37	8	133880403	133880403	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:133880403G>C	uc003ytw.2	+	2	152	c.111G>C	c.(109-111)CAG>CAC	p.Q37H		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	37	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTGAGCTGCAGAGGGAAACGG	0.547			NA											13	114					0	0	0.00245	0	0
TG	7038	broad.mit.edu	37	8	133883613	133883613	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:133883613C>A	uc003ytw.2	+	4	336	c.295C>A	c.(295-297)CAG>AAG	p.Q99K		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	99	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTGTCAGCTACAGAAACAGCA	0.502			NA											20	227					1.64113e-05	1.8373e-05	0.010504	1	0
BAI1	575	broad.mit.edu	37	8	143603424	143603424	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:143603424G>T	uc003ywm.2	+	20	3306	c.3123G>T	c.(3121-3123)ACG>ACT	p.T1041T		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1041	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGGCGGTGACGGGCCACCTCC	0.667			NA											8	24					0.000673444	0.000736759	0.008291	1	0
GPR172A	79581	broad.mit.edu	37	8	145583767	145583767	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:145583767C>T	uc003zcc.1	+	3	772	c.615C>T	c.(613-615)GTC>GTT	p.V205V	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Silent_p.V205V|GPR172A_uc003zce.1_Silent_p.V205V|GPR172A_uc010mfy.1_Silent_p.V205V|GPR172A_uc003zcf.1_Silent_p.V205V|GPR172A_uc011llc.1_Silent_p.V117V	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	205	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCCTTCTGGTCGCTTCAGCTG	0.652			NA											15	84					0	0	0.004007	0	0
TRPM3	80036	broad.mit.edu	37	9	73152282	73152282	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:73152282C>T	uc004aid.2	-	25	3955	c.3711G>A	c.(3709-3711)GAG>GAA	p.E1237E	TRPM3_uc004ahu.2_Silent_p.E1079E|TRPM3_uc004ahv.2_Silent_p.E1039E|TRPM3_uc004ahw.2_Silent_p.E1109E|TRPM3_uc004ahx.2_Silent_p.E1096E|TRPM3_uc004ahy.2_Silent_p.E1099E|TRPM3_uc004ahz.2_Silent_p.E1086E|TRPM3_uc004aia.2_Silent_p.E1084E|TRPM3_uc004aib.2_Silent_p.E1074E|TRPM3_uc004aic.2_Silent_p.E1237E	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1262	Cytoplasmic (Potential).|Potential.					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AGTGCTCTCTCTCGTTGACTT	0.602			NA											14	25					0	0	0.003163	0	0
TRPM6	140803	broad.mit.edu	37	9	77415379	77415379	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:77415379G>A	uc004ajl.1	-	17	2267	c.2029C>T	c.(2029-2031)CTG>TTG	p.L677L	TRPM6_uc004ajk.1_Silent_p.L672L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Silent_p.L55L	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	677	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						AACAAGTCCAGAGCCAGCTGG	0.458			NA											7	37					0	0	0.001984	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320553	79320553	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:79320553C>G	uc010mpk.2	-	8	6761	c.6637G>C	c.(6637-6639)GAT>CAT	p.D2213H	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2213					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGTGCCATATCTGGGCTGGCT	0.448			NA											24	66					0	0	0.004656	0	0
C9orf103	414328	broad.mit.edu	37	9	86258488	86258488	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:86258488C>G	uc004amu.1	+	5	371	c.357C>G	c.(355-357)CTC>CTG	p.L119L	C9orf103_uc004amt.1_Silent_p.L73L|C9orf103_uc010mpv.1_Silent_p.L73L	NM_001001551	NP_001001551	Q5T6J7	GNTK_HUMAN	gluconokinase-like protein	119					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity				0						AGATGCAGCTCCTGGTGGTCC	0.478			NA											16	47					0	0	0.004007	0	0
KIAA0368	23392	broad.mit.edu	37	9	114133964	114133964	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:114133964T>C	uc004bfe.1	-	44	5208	c.5208A>G	c.(5206-5208)CCA>CCG	p.P1736P		NM_001080398	NP_001073867			KIAA0368 protein												0						TTCCGAGATATGGAGGTACTA	0.483			NA											78	88					0	0	0.01441	0	0
LHX6	26468	broad.mit.edu	37	9	124989209	124989209	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:124989209G>A	uc010mvw.2	-	2	279	c.170C>T	c.(169-171)TCT>TTT	p.S57F	LHX6_uc004blx.3_Missense_Mutation_p.S86F|LHX6_uc004bly.3_Missense_Mutation_p.S86F	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	57	Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGAGGCGGCAGAGGGCGGTGA	0.647			NA											5	1					0	0	0.000602	0	0
SCAI	286205	broad.mit.edu	37	9	127904938	127904938	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:127904938C>G	uc004bpe.2	-	2	153	c.72G>C	c.(70-72)GAG>GAC	p.E24D	SCAI_uc004bpd.2_Missense_Mutation_p.E24D|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	24	Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						GAGGCGGTTTCTCCACTGTGC	0.463			NA											4	32					0	0	0.009096	0	0
FNBP1	23048	broad.mit.edu	37	9	132687277	132687277	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:132687277A>C	uc004byw.1	-	9	1168	c.949T>G	c.(949-951)TCC>GCC	p.S317A	FNBP1_uc011mbv.1_Missense_Mutation_p.S317A|FNBP1_uc011mbw.1_Missense_Mutation_p.S317A|FNBP1_uc004bza.2_Missense_Mutation_p.S317A|FNBP1_uc004byz.1_Missense_Mutation_p.S317A|FNBP1_uc004byx.1_Missense_Mutation_p.S238A|FNBP1_uc004byy.1_Missense_Mutation_p.S238A	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	317	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		TTTCCTTTGGATTTGCCACCA	0.403			NA	T	MLL	AML								7	20					0	0	0.00308	0	0
TBL1X	6907	broad.mit.edu	37	X	9679741	9679741	+	Silent	SNP	C	C	T	rs139999402		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:9679741C>T	uc010ndq.2	+	16	1898	c.1530C>T	c.(1528-1530)AGC>AGT	p.S510S	TBL1X_uc004csq.3_Silent_p.S459S|TBL1X_uc010ndr.2_Silent_p.S459S|TBL1X_uc004csr.2_Silent_p.S510S|TBL1X_uc004css.2_Silent_p.S461S	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	510	WD 7.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				CTGTCTATAGCGTAGCTTTCA	0.532			NA											25	8					0	0	0.00278	0	0
MSL3	10943	broad.mit.edu	37	X	11778578	11778578	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:11778578G>C	uc004cuw.2	+	3	347	c.242G>C	c.(241-243)AGA>ACA	p.R81T	MSL3_uc004cuv.1_Missense_Mutation_p.R81T|MSL3_uc004cux.2_Missense_Mutation_p.R22T|MSL3_uc011mig.1_5'UTR|MSL3_uc011mih.1_Missense_Mutation_p.R69T|MSL3_uc004cuy.2_5'UTR|MSL3_uc011mii.1_5'UTR	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	81	Chromo.				histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAAAATCGTAGATTACAGCGT	0.348			NA											21	15					0	0	0.012319	0	0
WDR45	11152	broad.mit.edu	37	X	48933333	48933333	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:48933333G>A	uc004dmk.1	-	8	768	c.596C>T	c.(595-597)TCT>TTT	p.S199F	PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Missense_Mutation_p.S97F|WDR45_uc004dmj.1_Missense_Mutation_p.S160F|WDR45_uc004dml.1_Missense_Mutation_p.S200F|WDR45_uc004dmm.1_Missense_Mutation_p.S164F|WDR45_uc010nim.1_Missense_Mutation_p.S199F|WDR45_uc004dmn.1_Missense_Mutation_p.S90F|WDR45_uc004dmo.1_Missense_Mutation_p.S222F|WDR45_uc004dmp.1_Missense_Mutation_p.S200F	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	199	WD 2.				autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						CTGGTTTAGAGACACACAGGC	0.562			NA											7	3					0	0	0.001984	0	0
TRO	7216	broad.mit.edu	37	X	54956769	54956769	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:54956769C>A	uc004dtq.2	+	12	3719	c.3612C>A	c.(3610-3612)AGC>AGA	p.S1204R	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.S735R|TRO_uc004dtw.2_Missense_Mutation_p.S807R|TRO_uc004dtx.2_Missense_Mutation_p.S587R	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1204	62 X 10 AA approximate tandem repeats.|40.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ATGGGTTAAGCACCAATGCTG	0.552			NA											23	14					3.62473e-10	4.29598e-10	0.012319	1	0
MED12	9968	broad.mit.edu	37	X	70340946	70340946	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:70340946G>C	uc004dyy.2	+	5	878	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	MED12_uc011mpq.1_Missense_Mutation_p.E227Q|MED12_uc004dyz.2_Missense_Mutation_p.E227Q|MED12_uc004dza.2_Missense_Mutation_p.E74Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	227					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CCATGATGTAGAGGTGGCAAT	0.557			NA											24	59					0	0	0.003954	0	0
UPRT	139596	broad.mit.edu	37	X	74494380	74494380	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:74494380A>G	uc004ecb.1	+	1	420	c.291A>G	c.(289-291)CTA>CTG	p.L97L	UPRT_uc010nlu.1_Silent_p.L97L|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Silent_p.L97L|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	97					nucleoside metabolic process	cytoplasm|nucleus					0						ACTCCTTCCTAGAGGACTGCG	0.577			NA											17	9					0	0	0.00499	0	0
ZNF711	7552	broad.mit.edu	37	X	84510281	84510281	+	Silent	SNP	T	T	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:84510281T>G	uc004eeo.2	+	4	443	c.96T>G	c.(94-96)GGT>GGG	p.G32G	ZNF711_uc004eep.2_Silent_p.G32G|ZNF711_uc004eeq.2_Silent_p.G32G	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	32					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						GAATGGCTGGTACTGCACATA	0.328			NA											7	21					0	0	0.010504	0	0
PABPC5	140886	broad.mit.edu	37	X	90691232	90691232	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:90691232T>C	uc004efg.2	+	2	1096	c.656T>C	c.(655-657)TTC>TCC	p.F219S	PABPC5_uc004eff.1_Missense_Mutation_p.F55S	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	219	RRM 3.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						AAGGAACTTTTCTGTGAATAT	0.438			NA											15	14					0	0	0.00245	0	0
DDX26B	203522	broad.mit.edu	37	X	134679428	134679428	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:134679428G>C	uc004eyw.3	+	3	633	c.270G>C	c.(268-270)CAG>CAC	p.Q90H		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	90	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTCGGTCAGGCTCTAAGAT	0.358			NA											30	40					0	0	0.007291	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716991	142716991	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:142716991C>T	uc004fbx.2	-	2	2310	c.1934G>A	c.(1933-1935)CGC>CAC	p.R645H	SLITRK4_uc004fby.2_Missense_Mutation_p.R645H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	645	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCTTGTTGCGTCGCAGGAC	0.458			NA											25	61					0	0	0.00333	0	0
OR14A16	284532	broad.mit.edu	37	1	247978907	247978921	+	In_Frame_Del	DEL	AGGACATTCCCCATC	AGGACATTCCCCATC	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	AGGACATTCCCCATC	AGGACATTCCCCATC	-	-	AGGACATTCCCCATC	AGGACATTCCCCATC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:247978907_247978921delAGGACATTCCCCATC	uc001idm.1	-	1	111_125	c.111_125delGATGGGGAATGTCCT	c.(109-126)CTGATGGGGAATGTCCTC>CTC	p.37_42LMGNVL>L		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	37_42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATGATAATGAGGACATTCCCCATCAGGGCACACA	0.386	Ovarian(112;180 1586 15073 21914 33526)		NA											15	35	---	---	---	---	NA	NA	NA	NA	NA
MTSS1L	92154	broad.mit.edu	37	16	70697685	70697694	+	Frame_Shift_Del	DEL	GGCTGGGGGT	GGCTGGGGGT	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	GGCTGGGGGT	GGCTGGGGGT	-	-	GGCTGGGGGT	GGCTGGGGGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:70697685_70697694delGGCTGGGGGT	uc002ezj.2	-	15	2390_2399	c.2130_2139delACCCCCAGCC	c.(2128-2139)CCACCCCCAGCCfs	p.P710fs		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	710_713					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						CGCTGGTGGCGGCTGGGGGTGGGGTGGGCG	0.733			NA											3	3	---	---	---	---	NA	NA	NA	NA	NA
CEP68	23177	broad.mit.edu	37	2	65296785	65296786	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:65296785_65296786insA	uc002sdl.3	+	2	421_422	c.207_208insA	c.(205-210)GGGACTfs	p.G69fs	CEP68_uc002sdj.2_Frame_Shift_Ins_p.G69fs|CEP68_uc010yqb.1_Frame_Shift_Ins_p.G69fs|CEP68_uc002sdk.3_Frame_Shift_Ins_p.G69fs|CEP68_uc010yqc.1_Frame_Shift_Ins_p.G69fs|CEP68_uc010yqd.1_Frame_Shift_Ins_p.G69fs	NM_015147	NP_055962	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	69_70					centrosome organization	centrosome				skin(1)	1						GCTGGATTGGGACTGACCCTGG	0.649			NA											61	56	---	---	---	---	NA	NA	NA	NA	NA
PRKG2	5593	broad.mit.edu	37	4	82074817	82074817	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:82074817delA	uc003hmh.2	-	6	985	c.971delT	c.(970-972)TTCfs	p.F324fs	PRKG2_uc011ccf.1_5'UTR|PRKG2_uc011ccg.1_5'UTR|PRKG2_uc011cch.1_Frame_Shift_Del_p.F324fs	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	324	cGMP 2.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						TGCCAAAATGAAAAAGGTACT	0.313			NA											8	138	---	---	---	---	NA	NA	NA	NA	NA
SAMD9	54809	broad.mit.edu	37	7	92733829	92733829	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:92733829delG	uc003umf.2	-	3	1838	c.1582delC	c.(1582-1584)CTTfs	p.L528fs	SAMD9_uc003umg.2_Frame_Shift_Del_p.L528fs	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	528						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCATGTGTAAGAAATGAAATC	0.408			NA											14	289	---	---	---	---	NA	NA	NA	NA	NA
GRHL2	79977	broad.mit.edu	37	8	102656404	102656405	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:102656404_102656405insT	uc010mbu.2	+	13	1893_1894	c.1563_1564insT	c.(1561-1566)GAGTTTfs	p.E521fs		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	521_522						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TGGAAGAGGAGTTTGGTCCAGT	0.495			NA											11	53	---	---	---	---	NA	NA	NA	NA	NA
RORB	6096	broad.mit.edu	37	9	77286749	77286750	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:77286749_77286750insA	uc004aji.2	+	9	1238_1239	c.1189_1190insA	c.(1189-1191)GAAfs	p.E397fs	RORB_uc004ajh.2_Frame_Shift_Ins_p.E386fs	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	397	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GAAGCTTCAGGAAAAAATTTAT	0.446			NA											7	26	---	---	---	---	NA	NA	NA	NA	NA
GRIPAP1	56850	broad.mit.edu	37	X	48849862	48849863	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:48849862_48849863delTG	uc004dly.1	-	6	469_470	c.434_435delCA	c.(433-435)ACAfs	p.T145fs	GRIPAP1_uc004dlz.2_5'Flank|GRIPAP1_uc004dma.2_Intron	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	145	Potential.					early endosome				breast(2)|kidney(1)	3						TCTGCAAGGCTGTGTTTTCAGC	0.614			NA											11	6	---	---	---	---	NA	NA	NA	NA	NA
