Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACTRT2	140625	broad.mit.edu	37	1	2939246	2939246	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:2939246G>T	uc001ajz.2	+	1	1201	c.996G>T	c.(994-996)ACG>ACT	p.T332T		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	332						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCAAGATCACGGCTCCCCCCG	0.617			NA											63	96					1.08141e-31	1.66632e-31	0.048971	1	0
TAS1R2	80834	broad.mit.edu	37	1	19181198	19181198	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:19181198G>A	uc001bba.1	-	3	767	c.766C>T	c.(766-768)CGC>TGC	p.R256C		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	256	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GTCACCAGGCGCTGGCGCTCC	0.637			NA											7	33					0	0	0.038147	0	0
WNT4	54361	broad.mit.edu	37	1	22456296	22456296	+	Silent	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:22456296C>G	uc001bfs.3	-	2	230	c.126G>C	c.(124-126)ACG>ACC	p.T42T	WNT4_uc010odt.1_5'UTR	NM_030761	NP_110388	P56705	WNT4_HUMAN	wingless-type MMTV integration site family,	42					adrenal gland development|androgen biosynthetic process|anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|dermatome development|endoderm development|epithelial to mesenchymal transition|establishment of protein localization in plasma membrane|female gonad development|female sex determination|liver development|male gonad development|mesonephric tubule development|metanephric mesenchymal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of male gonad development|negative regulation of testicular blood vessel morphogenesis|negative regulation of testosterone biosynthetic process|negative regulation of transcription, DNA-dependent|oocyte development|paramesonephric duct development|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of collagen biosynthetic process|positive regulation of cortisol biosynthetic process|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|protein palmitoylation|renal vesicle formation|smooth muscle cell differentiation|somatotropin secreting cell differentiation|tertiary branching involved in mammary gland duct morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|extracellular space|Golgi apparatus|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|signal transducer activity|transcription corepressor activity			ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;9.02e-26)|Colorectal(126;1.71e-07)|COAD - Colon adenocarcinoma(152;1.17e-05)|GBM - Glioblastoma multiforme(114;2.01e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000568)|KIRC - Kidney renal clear cell carcinoma(1967;0.00277)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		GTTTCTCGCACGTCTCCTCCT	0.622			NA											62	135					0	0	0.048971	0	0
C1orf128	57095	broad.mit.edu	37	1	24112859	24112859	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:24112859C>T	uc001bhq.2	+	5	610	c.480C>T	c.(478-480)TTC>TTT	p.F160F	C1orf128_uc010oeb.1_Silent_p.F67F	NM_020362	NP_065095	Q9GZP4	PITH1_HUMAN	chromosome 1 open reading frame 128	160	PITH.										0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.0034)|all_lung(284;0.00519)|Breast(348;0.0222)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.97e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		CAAAAAACTTCGGAGCAGATA	0.388			NA											17	43					0	0	0.038395	0	0
CSMD2	114784	broad.mit.edu	37	1	34002679	34002679	+	Silent	SNP	C	C	A	rs61801993	byFrequency	TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:34002679C>A	uc001bxn.1	-	61	9419	c.9390G>T	c.(9388-9390)ACG>ACT	p.T3130T	CSMD2_uc001bxm.1_Silent_p.T3274T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3130	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGTCCGCACACGTGGTCAGGG	0.517			NA											4	96					1.23904e-05	1.37984e-05	0.014758	1	0
RAD54L	8438	broad.mit.edu	37	1	46726628	46726628	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:46726628G>C	uc009vye.2	+	8	821	c.707G>C	c.(706-708)GGG>GCG	p.G236A	RAD54L_uc001cpl.2_Missense_Mutation_p.G236A|RAD54L_uc001cpm.1_Missense_Mutation_p.G56A	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	236	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		TGGCTCGGAGGGAGGATCCAA	0.532			NA						Direct_reversal_of_damage|Homologous_recombination					13	30					0	0	0.09319	0	0
DAB1	1600	broad.mit.edu	37	1	57480898	57480898	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:57480898G>T	uc001cys.1	-	14	1776	c.1102C>A	c.(1102-1104)CCC>ACC	p.P368T	DAB1_uc001cyt.1_Missense_Mutation_p.P366T|DAB1_uc001cyq.1_Missense_Mutation_p.P366T|DAB1_uc001cyr.1_Missense_Mutation_p.P282T|DAB1_uc009vzw.1_Missense_Mutation_p.P350T|DAB1_uc009vzx.1_Missense_Mutation_p.P368T	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	401					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GTTTGTGTGGGCATGAAGGCG	0.647			NA											39	83					1.03484e-13	1.33439e-13	0.080422	1	0
UBE2U	148581	broad.mit.edu	37	1	64671320	64671320	+	Splice_Site	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:64671320A>G	uc001dbn.1	+	2	311	c.67_splice	c.e2-2	p.G23_splice		NM_152489	NP_689702	Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)								ATP binding|protein binding|ubiquitin-protein ligase activity				0						TTTAACTTCAAGGGTATCACT	0.303			NA											24	44					0	0	0.076483	0	0
LOC200030	200030	broad.mit.edu	37	1	148344690	148344690	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:148344690C>G	uc001eqf.2	-	2	263	c.228G>C	c.(226-228)CAG>CAC	p.Q76H	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|NBPF14_uc009wkf.1_Intron|uc001erd.3_Missense_Mutation_p.Q76H|uc001erc.3_Intron|uc010paj.1_Intron|uc010pau.1_5'Flank|uc010pav.1_Missense_Mutation_p.Q76H|uc010paw.1_Intron	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	76	Potential.					cytoplasm					0						CCTCCTTGAACTGTCGCTCAT	0.532			NA											20	534					0	0	0.059317	0	0
FLG2	388698	broad.mit.edu	37	1	152329873	152329873	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:152329873C>T	uc001ezw.3	-	3	462	c.389G>A	c.(388-390)AGA>AAA	p.R130K	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	130							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTTGAATGTCTGTAACCTGA	0.478			NA											85	180					0	0	0.048971	0	0
LCE2A	353139	broad.mit.edu	37	1	152671522	152671522	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:152671522G>T	uc001faj.2	+	2	196	c.145G>T	c.(145-147)GGG>TGG	p.G49W		NM_178428	NP_848515	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	49	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCAGCTCTGGGGGCTGCTG	0.687			NA											60	156					1.80625e-27	2.69837e-27	0.048971	1	0
SLC25A44	9673	broad.mit.edu	37	1	156169858	156169858	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:156169858T>C	uc001fnp.2	+	2	542	c.220T>C	c.(220-222)TAC>CAC	p.Y74H	SLC25A44_uc010phc.1_Intron|SLC25A44_uc009wrr.2_Missense_Mutation_p.Y74H|SLC25A44_uc010phd.1_Intron|SLC25A44_uc010phe.1_Intron	NM_014655	NP_055470	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	74	Solcar 1.|Helical; Name=2; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	Hepatocellular(266;0.158)					CACTGGCCTCTACCGAGGGTT	0.537			NA											18	37					0	0	0.038395	0	0
SMG5	23381	broad.mit.edu	37	1	156244463	156244463	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:156244463C>A	uc001foc.3	-	5	618	c.469G>T	c.(469-471)GTG>TTG	p.V157L		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	157					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GAGGCAGACACTGGCTTCTTG	0.478			NA											38	75					3.78316e-11	4.58848e-11	0.086207	1	0
OR6N2	81442	broad.mit.edu	37	1	158747268	158747268	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:158747268G>A	uc010pir.1	-	1	158	c.158C>T	c.(157-159)GCA>GTA	p.A53V		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					GTGCAGAGCTGCATCCAGTCG	0.468			NA											65	118					0	0	0.048971	0	0
ATP1A4	480	broad.mit.edu	37	1	160141399	160141399	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:160141399G>T	uc001fve.3	+	12	2185	c.1706G>T	c.(1705-1707)AGC>ATC	p.S569I	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.S72I	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	569	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AATCTGCCTAGCAGCTTCTCC	0.473			NA											96	182					8.2166e-39	1.28221e-38	0.048971	1	0
FCGR3B	2215	broad.mit.edu	37	1	161595976	161595976	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:161595976T>G	uc009wul.2	-	4	810	c.536A>C	c.(535-537)AAA>ACA	p.K179T		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	179	Ig-like C2-type 2.				immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGACACATTTTTACTCCCAAC	0.483			NA											8	118					0	0	0.058154	0	0
NUF2	83540	broad.mit.edu	37	1	163315595	163315595	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:163315595G>T	uc001gcq.1	+	11	1235	c.935G>T	c.(934-936)AGT>ATT	p.S312I	NUF2_uc001gcp.2_Missense_Mutation_p.S312I|NUF2_uc001gcr.1_Missense_Mutation_p.S312I|NUF2_uc009wvc.1_Intron	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	312	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					AAATTAGCCAGTATCTTAAAG	0.328			NA											22	83					1.64113e-05	1.81936e-05	0.055883	1	0
ILDR2	387597	broad.mit.edu	37	1	166890569	166890569	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:166890569G>T	uc001gdx.1	-	9	1315	c.1259C>A	c.(1258-1260)ACG>AAG	p.T420K		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	420	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						CGGCACCCCCGTGGCGAAGTT	0.716			NA											13	18					4.93089e-13	6.32496e-13	0.020292	1	0
DUSP27	92235	broad.mit.edu	37	1	167097764	167097764	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:167097764G>T	uc001geb.1	+	5	3396	c.3396G>T	c.(3394-3396)ATG>ATT	p.M1132I		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1132					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGGAAGAAATGGACGATGAAG	0.522			NA											18	32					3.99206e-14	5.17489e-14	0.043863	1	0
TNR	7143	broad.mit.edu	37	1	175355377	175355377	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:175355377T>A	uc001gkp.1	-	6	1649	c.1568A>T	c.(1567-1569)GAG>GTG	p.E523V	TNR_uc009wwu.1_Missense_Mutation_p.E523V	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	523	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGGAATCCACTCCACAAAAGC	0.537			NA											15	30					0	0	0.020292	0	0
TNR	7143	broad.mit.edu	37	1	175375666	175375666	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:175375666G>A	uc001gkp.1	-	1	266	c.185C>T	c.(184-186)CCT>CTT	p.P62L	TNR_uc009wwu.1_Missense_Mutation_p.P62L|TNR_uc010pmz.1_Missense_Mutation_p.P62L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	62					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GAAGACCACAGGCTGCTCTTT	0.552			NA											67	133					0	0	0.048971	0	0
PAPPA2	60676	broad.mit.edu	37	1	176709187	176709187	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:176709187C>T	uc001gkz.2	+	14	5170	c.4006C>T	c.(4006-4008)CAC>TAC	p.H1336Y	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1336					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGTCCTTTTCCACCATACCAC	0.488			NA											65	87					0	0	0.048971	0	0
ASTN1	460	broad.mit.edu	37	1	176863906	176863906	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:176863906G>A	uc001glc.2	-	17	2944	c.2732C>T	c.(2731-2733)CCA>CTA	p.P911L	ASTN1_uc001glb.1_Missense_Mutation_p.P911L|ASTN1_uc001gld.1_Missense_Mutation_p.P911L	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	919					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GATGTATTCTGGGAATGTCAG	0.562			NA											47	88					0	0	0.048971	0	0
FAM5B	57795	broad.mit.edu	37	1	177226442	177226443	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:177226442_177226443GG>CT	uc001glf.2	+	4	903_904	c.591_592GG>CT	c.(589-594)CTGGCC>CTCTCC	p.A198S	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Missense_Mutation_p.A93S	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	198						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TGCACCAGCTGGCCGCCTCCTA	0.579			NA											10	33					0	0	0.004672	0	0
ZBTB41	360023	broad.mit.edu	37	1	197141290	197141290	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:197141290C>G	uc001gtx.1	-	9	2143	c.2074G>C	c.(2074-2076)GGT>CGT	p.G692R	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TAAATTTTACCTGAATGCGTT	0.264			NA											5	4					0	0	0.047766	0	0
CAMK1G	57172	broad.mit.edu	37	1	209782371	209782371	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:209782371T>C	uc001hhd.2	+	8	784	c.682T>C	c.(682-684)TTC>CTC	p.F228L	CAMK1G_uc001hhf.3_Missense_Mutation_p.F228L|CAMK1G_uc001hhe.2_Missense_Mutation_p.F228L	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	228	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		GTCTAAGCTTTTCGAGAAGAT	0.493	Ovarian(163;530 1939 9680 28669 48710)		NA											71	112					0	0	0.048971	0	0
PGBD5	79605	broad.mit.edu	37	1	230472975	230472975	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:230472975C>A	uc010pwb.1	-	4	747	c.747G>T	c.(745-747)AAG>AAT	p.K249N	PGBD5_uc001htv.2_Missense_Mutation_p.K348N	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	249						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GGAGCTGGGGCTTATTCTTCA	0.567			NA											21	35					2.39187e-15	3.18483e-15	0.049695	1	0
HEATR1	55127	broad.mit.edu	37	1	236719125	236719125	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:236719125A>C	uc001hyd.1	-	39	5754	c.5629T>G	c.(5629-5631)TTC>GTC	p.F1877V	HEATR1_uc009xgh.1_Missense_Mutation_p.F1039V	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1877					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGGGCTCGGAAGTCCAGGGCT	0.493			NA											13	137					0	0	0.105934	0	0
OR2M2	391194	broad.mit.edu	37	1	248343812	248343812	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:248343812C>A	uc010pzf.1	+	1	525	c.525C>A	c.(523-525)GCC>GCA	p.A175A		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGGAAATAGCCCACTTCTTCT	0.423			NA											199	321					9.29173e-92	1.48789e-91	0.048971	1	0
OR2M7	391196	broad.mit.edu	37	1	248487522	248487523	+	Missense_Mutation	DNP	CA	CA	AG	rs140426612		TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:248487522_248487523CA>AG	uc010pzk.1	-	1	348_349	c.348_349TG>CT	c.(346-351)GCTGTT>GCCTTT	p.V117F		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAAGACATAACAGCCAACAGAA	0.441			NA											158	254					0	0	0.004672	0	0
SFMBT2	57713	broad.mit.edu	37	10	7325988	7325988	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr10:7325988C>T	uc009xio.1	-	6	741	c.650G>A	c.(649-651)CGC>CAC	p.R217H	SFMBT2_uc001ijn.1_Missense_Mutation_p.R217H|SFMBT2_uc010qay.1_Missense_Mutation_p.R217H	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	217	MBT 2.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						ATAGCGAAGGCGTAATCTTCC	0.418			NA											51	65					0	0	0.048971	0	0
ITIH5	80760	broad.mit.edu	37	10	7608297	7608297	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr10:7608297C>T	uc001ijq.2	-	13	2302	c.2223G>A	c.(2221-2223)TTG>TTA	p.L741L	ITIH5_uc001ijp.2_Silent_p.L527L	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	741					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TGATAGTGCGCAAGTAAGTGC	0.527			NA											15	13					0	0	0.0333	0	0
ITIH5	80760	broad.mit.edu	37	10	7611748	7611748	+	Splice_Site	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr10:7611748C>T	uc001ijq.2	-	12	2112	c.2033_splice	c.e12-1	p.V678_splice	ITIH5_uc001ijp.2_Splice_Site_p.V464_splice	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain						hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TCACCATCCACTGCCAGAGCA	0.363			NA											5	21					0	0	0.014758	0	0
OPTN	10133	broad.mit.edu	37	10	13154608	13154608	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr10:13154608A>G	uc001ilu.1	+	6	963	c.525A>G	c.(523-525)GAA>GAG	p.E175E	OPTN_uc001ilv.1_Silent_p.E175E|OPTN_uc001ilw.1_Silent_p.E175E|OPTN_uc001ilx.1_Silent_p.E175E|OPTN_uc001ily.1_Silent_p.E175E|OPTN_uc010qbr.1_Silent_p.E118E|OPTN_uc001ilz.1_Silent_p.E175E	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	175	Interaction with Rab8.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						GCTCCTCAGAAGATTCCTTTG	0.463			NA											52	81					0	0	0.048971	0	0
CHST3	9469	broad.mit.edu	37	10	73767038	73767038	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr10:73767038C>A	uc001jsn.2	+	3	689	c.249C>A	c.(247-249)CTC>CTA	p.L83L		NM_004273	NP_004264	Q7LGC8	CHST3_HUMAN	chondroitin 6-sulfotransferase 3	83	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity				0						TGAGCGAGCTCGATTCAGCCT	0.597			NA											22	10					3.8784e-16	5.22093e-16	0.062417	1	0
PDZD8	118987	broad.mit.edu	37	10	119078424	119078424	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr10:119078424T>G	uc001lde.1	-	3	1256	c.1057A>C	c.(1057-1059)AGT>CGT	p.S353R		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	353					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CAAACACTACTGCTTAACTCA	0.338			NA											14	53					0	0	0.028581	0	0
OR51D1	390038	broad.mit.edu	37	11	4661574	4661574	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:4661574A>G	uc010qyk.1	+	1	554	c.554A>G	c.(553-555)CAT>CGT	p.H185R		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCCAAACACATACTGTCACA	0.478			NA											71	52					0	0	0.048971	0	0
TRIM22	10346	broad.mit.edu	37	11	5719619	5719619	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:5719619G>T	uc001mbr.2	+	4	871	c.594G>T	c.(592-594)GAG>GAT	p.E198D	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Missense_Mutation_p.E166D|TRIM22_uc009yes.2_Missense_Mutation_p.E194D|TRIM22_uc010qzm.1_Missense_Mutation_p.E26D|TRIM22_uc009yeu.2_Missense_Mutation_p.E9D	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	198	Potential.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ACAATGAGGAGCAGAGAGAGC	0.483	GBM(104;491 2336 5222)		NA											29	30					1.39806e-14	1.82193e-14	0.037714	1	0
OR52N2	390077	broad.mit.edu	37	11	5842468	5842468	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:5842468G>T	uc010qzp.1	+	1	903	c.903G>T	c.(901-903)CAG>CAT	p.Q301H	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGACCAAGCAGATTCAGGAAG	0.383			NA											57	38					1.78197e-24	2.55311e-24	0.048971	1	0
MAPK8IP1	9479	broad.mit.edu	37	11	45925566	45925566	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:45925566T>G	uc001nbr.2	+	7	1690	c.1520T>G	c.(1519-1521)CTT>CGT	p.L507R		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	507	SH3.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		GAAGACGAACTTGAGCTGGAA	0.587			NA											10	139					0	0	0.080935	0	0
SPRYD5	84767	broad.mit.edu	37	11	55655631	55655631	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:55655631C>A	uc010rip.1	+	4	723	c.631C>A	c.(631-633)CAA>AAA	p.Q211K	SPRYD5_uc010riq.1_Missense_Mutation_p.Q68K	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	211						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CATTTTTCAGCAACTCAATGA	0.443			NA											5	88					2.27111e-07	2.61231e-07	0.09319	1	0
SPRYD5	84767	broad.mit.edu	37	11	55658922	55658922	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:55658922C>A	uc010rip.1	+	7	1265	c.1173C>A	c.(1171-1173)CTC>CTA	p.L391L	SPRYD5_uc010riq.1_Silent_p.L248L	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	391	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				ACTGCAGTCTCTTTACCACCT	0.443			NA											32	68					3.38236e-24	4.81789e-24	0.092188	1	0
OR8H1	219469	broad.mit.edu	37	11	56058409	56058410	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:56058409_56058410CC>GA	uc010rje.1	-	1	129_130	c.129_130GG>TC	c.(127-132)GTGGGG>GTTCGG	p.G44R		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					AATATCATCCCCACATTGCCCA	0.426			NA											96	213					0	0	0.004672	0	0
MS4A3	932	broad.mit.edu	37	11	59834462	59834462	+	Silent	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:59834462A>T	uc001nom.2	+	5	518	c.390A>T	c.(388-390)ACA>ACT	p.T130T	MS4A3_uc001non.2_Silent_p.T84T|MS4A3_uc001noo.2_Silent_p.T7T	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	130	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				CCAGTGCTACAATTGCACTAG	0.373			NA											20	17					0	0	0.069288	0	0
PGR	5241	broad.mit.edu	37	11	100922259	100922259	+	Silent	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:100922259A>T	uc001pgh.2	-	5	2996	c.2253T>A	c.(2251-2253)ATT>ATA	p.I751I	PGR_uc001pgg.2_Silent_p.I132I|PGR_uc001pgi.2_Silent_p.I649I|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	751	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	AAGAATACTGAATGAGAGTTA	0.343	Pancreas(124;2271 2354 21954 22882)		NA											28	68					0	0	0.108266	0	0
TRPC6	7225	broad.mit.edu	37	11	101454093	101454093	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:101454093G>C	uc001pgk.3	-	1	567	c.142C>G	c.(142-144)CTG>GTG	p.L48V	TRPC6_uc009ywy.2_Missense_Mutation_p.L48V|TRPC6_uc009ywz.1_Missense_Mutation_p.L48V	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	48	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TAGCAAGGCAGCGGGGCTTGC	0.721	Colon(166;1315 1927 11094 12848 34731)		NA											6	9					0	0	0.047766	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110035866	110035866	+	Silent	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:110035866A>C	uc009yxw.2	+	6	2107	c.2056A>C	c.(2056-2058)AGA>CGA	p.R686R	ZC3H12C_uc010rwc.1_Silent_p.R687R|ZC3H12C_uc010rwd.1_Silent_p.R687R|ZC3H12C_uc001pkr.3_Silent_p.R655R	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	686							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		CCCCTTAACCAGAGGGCAAAG	0.562			NA											64	258					0	0	0.048971	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117789384	117789384	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:117789384G>A	uc001prs.1	-	2	284	c.191C>T	c.(190-192)ACA>ATA	p.T64I	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.T64I	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	64	4 X 5 AA repeats of T-P-P-G-R.|2-4.|12 X 5 AA repeats of A-S-P-A-[GLQR].|Cytoplasmic (Potential).|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GCCTGGAGGTGTACCAGCTGG	0.687			NA											26	46					0	0	0.034045	0	0
OR8D2	283160	broad.mit.edu	37	11	124189725	124189725	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:124189725A>G	uc010sah.1	-	1	369	c.369T>C	c.(367-369)TAT>TAC	p.Y123Y		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AGATAGCAACATAACGGTCAT	0.418			NA											23	52					0	0	0.069288	0	0
KIRREL3	84623	broad.mit.edu	37	11	126306850	126306850	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:126306850C>A	uc001qea.2	-	12	1769	c.1408G>T	c.(1408-1410)GTG>TTG	p.V470L	KIRREL3_uc001qeb.2_Missense_Mutation_p.V470L|KIRREL3_uc001qec.1_Missense_Mutation_p.V470L|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	470	Extracellular (Potential).|Ig-like C2-type 5.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		ATGGTCTCCACCGTATAGCGC	0.642			NA											7	13					2.7689e-08	3.21507e-08	0.02938	1	0
KIRREL3	84623	broad.mit.edu	37	11	126318921	126318921	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr11:126318921C>T	uc001qea.2	-	8	1341	c.980G>A	c.(979-981)CGC>CAC	p.R327H	KIRREL3_uc001qeb.2_Missense_Mutation_p.R327H|KIRREL3_uc001qec.1_Missense_Mutation_p.R327H	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	327	Extracellular (Potential).|Ig-like C2-type 3.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		GTCAACCGTGCGGCTGAGGTT	0.587			NA											13	48					0	0	0.09319	0	0
ANO2	57101	broad.mit.edu	37	12	5685081	5685081	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr12:5685081A>T	uc001qnm.2	-	24	2612	c.2540T>A	c.(2539-2541)CTC>CAC	p.L847H		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	852	Extracellular (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GAAAAAGGAGAGGGTGTGGTT	0.517			NA											14	8					0	0	0.024245	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22487150	22487150	+	Missense_Mutation	SNP	C	C	T	rs146610334		TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr12:22487150C>T	uc001rfo.3	-	1	499	c.17G>A	c.(16-18)CGG>CAG	p.R6Q	ST8SIA1_uc009zix.2_5'UTR|uc001rfp.1_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	6	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						TCGCCGGGCCCGCCCGCAGGG	0.731			NA											21	22					0	0	0.055883	0	0
TSPAN11	441631	broad.mit.edu	37	12	31144811	31144811	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr12:31144811C>A	uc010sju.1	+	8	1103	c.723C>A	c.(721-723)ACC>ACA	p.T241T	TSPAN11_uc001rjp.2_Silent_p.T241T|TSPAN11_uc010sjv.1_Silent_p.T231T	NM_001080509	NP_001073978	A1L157	TSN11_HUMAN	tetraspanin 11	241						integral to membrane					0	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TGGTTCTCACCTGCTGCTTGC	0.577			NA											26	26					9.80776e-20	1.36528e-19	0.030593	1	0
PTGES3	10728	broad.mit.edu	37	12	57058275	57058275	+	Silent	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr12:57058275T>A	uc001slu.3	-	8	766	c.471A>T	c.(469-471)CCA>CCT	p.P157P	PTGES3_uc001slw.3_RNA|PTGES3_uc010sqs.1_Silent_p.P124P|PTGES3_uc001slv.3_Silent_p.P127P|PTGES3_uc010sqt.1_Silent_p.P136P|PTGES3_uc009zox.2_RNA	NM_006601	NP_006592	Q15185	TEBP_HUMAN	prostaglandin-E synthase 3	157	Asp/Glu-rich.				chaperone cofactor-dependent protein refolding|hormone biosynthetic process|prostaglandin biosynthetic process|signal transduction|telomere maintenance	cytosol|telomerase holoenzyme complex	prostaglandin-E synthase activity|telomerase activity|unfolded protein binding				0						ACTCCAGATCTGGCATTTCTG	0.299			NA											29	27					0	0	0.045705	0	0
IFT88	8100	broad.mit.edu	37	13	21199956	21199956	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr13:21199956G>C	uc001unh.2	+	17	1690	c.1294G>C	c.(1294-1296)GTT>CTT	p.V432L	IFT88_uc001uni.2_Missense_Mutation_p.V423L|IFT88_uc001unj.2_Missense_Mutation_p.V422L|IFT88_uc010tcq.1_Missense_Mutation_p.V403L|IFT88_uc001unk.2_Missense_Mutation_p.V178L|IFT88_uc001unl.1_Missense_Mutation_p.V50L	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	432	TPR 5.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		AAACAAAGCAGTTACATACTT	0.318			NA											24	10					0	0	0.0918	0	0
NBEA	26960	broad.mit.edu	37	13	35751179	35751179	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr13:35751179C>A	uc001uvb.2	+	28	4807	c.4601C>A	c.(4600-4602)CCG>CAG	p.P1534Q	NBEA_uc010abi.2_Missense_Mutation_p.P222Q	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1534						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATTAAGGATCCGGATAGACTT	0.348			NA											11	4					1.61879e-10	1.93465e-10	0.09319	1	0
LIG4	3981	broad.mit.edu	37	13	108863171	108863171	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr13:108863171T>A	uc001vqn.2	-	2	719	c.446A>T	c.(445-447)AAC>ATC	p.N149I	LIG4_uc001vqo.2_Missense_Mutation_p.N149I|LIG4_uc010agg.1_Missense_Mutation_p.N82I|LIG4_uc010agf.2_Missense_Mutation_p.N149I|LIG4_uc001vqp.2_Missense_Mutation_p.N149I	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	149					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TAAAAGGTCGTTTACTTGCTG	0.368			NA						NHEJ					108	47					0	0	0.048971	0	0
OR11H6	122748	broad.mit.edu	37	14	20691969	20691969	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:20691969G>T	uc010tlc.1	+	1	101	c.101G>T	c.(100-102)GGT>GTT	p.G34V		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	34	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GTCCTCCTGGGTTTCCATGGT	0.423			NA											75	54					6.6428e-20	9.29992e-20	0.048971	1	0
OR4E2	26686	broad.mit.edu	37	14	22133543	22133543	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:22133543G>T	uc010tmd.1	+	1	247	c.247G>T	c.(247-249)GAG>TAG	p.E83*		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TAAGATGTTGGAGGGTTTGCT	0.438			NA											143	119					4.23873e-62	6.74344e-62	0.048971	1	0
Unknown	0	broad.mit.edu	37	14	28733879	28733879	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:28733879T>G	uc001wqd.2	+	1	260	c.120T>G	c.(118-120)AAT>AAG	p.N40K						SubName: Full=cDNA FLJ60537, highly similar to BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;												NA						CTATTTATAATGGTGACATGG	0.527			NA											40	26					0	0	0.11126	0	0
DDHD1	80821	broad.mit.edu	37	14	53619470	53619470	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:53619470G>A	uc001xai.2	-	1	577	c.347C>T	c.(346-348)TCG>TTG	p.S116L	DDHD1_uc001xaj.2_Missense_Mutation_p.S116L|DDHD1_uc001xah.2_Missense_Mutation_p.S116L	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	116					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					CGGGTGCAGCGACAAGGAGCT	0.701			NA											9	2					0	0	0.047766	0	0
SAMD4A	23034	broad.mit.edu	37	14	55227114	55227114	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:55227114T>C	uc001xbb.2	+	6	1410	c.1409T>C	c.(1408-1410)CTC>CCC	p.L470P	SAMD4A_uc001xbc.2_Missense_Mutation_p.L382P|SAMD4A_uc001xbg.2_Missense_Mutation_p.L62P	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	471					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						AGCGGGGGGCTCCAGCCGCAC	0.736			NA											2	1					0	0	0.004672	0	0
TSHR	7253	broad.mit.edu	37	14	81609890	81609890	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:81609890G>A	uc001xvd.1	+	10	1644	c.1488G>A	c.(1486-1488)ACG>ACA	p.T496T		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	496	Helical; Name=3; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GGTGCAACACGGCTGGTTTCT	0.562			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						25	12					0	0	0.076483	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935754	94935754	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:94935754G>T	uc001ydf.2	-	2	639	c.478C>A	c.(478-480)CTG>ATG	p.L160M	SERPINA9_uc001yde.2_Intron|SERPINA9_uc010avc.2_Missense_Mutation_p.L11M|SERPINA9_uc001ydg.2_Missense_Mutation_p.L124M|SERPINA9_uc001ydh.1_Missense_Mutation_p.L160M|SERPINA9_uc001ydi.1_Missense_Mutation_p.L124M	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	142					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TGCAGCTGCAGCTCCTTCTTG	0.522			NA											70	56					6.52717e-41	1.0251e-40	0.048971	1	0
SERPINA13	388007	broad.mit.edu	37	14	95108087	95108087	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:95108087C>G	uc001ydt.2	+	2	692	c.604C>G	c.(604-606)CTG>GTG	p.L202V		NR_015340				RecName: Full=Serpin A13; Flags: Precursor;											lung(1)|skin(1)	2						GTTCAGCGGCCTGGGCGCGAG	0.627			NA											58	34					0	0	0.048971	0	0
ATG2B	55102	broad.mit.edu	37	14	96792136	96792136	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:96792136A>G	uc001yfi.2	-	15	2652	c.2287T>C	c.(2287-2289)TCT>CCT	p.S763P		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	763										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TCTTGATCAGATCGAAGATCA	0.393			NA											45	36					0	0	0.045515	0	0
GABRG3	2567	broad.mit.edu	37	15	27777965	27777965	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr15:27777965T>C	uc001zbg.1	+	10	1508	c.1342T>C	c.(1342-1344)TTT>CTT	p.F448L		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	448	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CTCCCGGGTCTTTTTCCCCAC	0.473	NSCLC(114;800 1656 7410 37729 45293)		NA											3	35					0	0	0.009096	0	0
DPP8	54878	broad.mit.edu	37	15	65782569	65782569	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr15:65782569C>G	uc002aov.2	-	6	2410	c.832G>C	c.(832-834)GAT>CAT	p.D278H	DPP8_uc002aow.2_Missense_Mutation_p.D278H|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.D262H|DPP8_uc002aoy.2_Missense_Mutation_p.D278H|DPP8_uc002aoz.2_Missense_Mutation_p.D262H|DPP8_uc010bhj.2_Missense_Mutation_p.D278H|DPP8_uc002apa.2_Missense_Mutation_p.D175H|DPP8_uc010bhk.1_Missense_Mutation_p.D20H	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	278					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						GAATATCTATCAAATTCTTCT	0.363			NA											37	30					0	0	0.09836	0	0
KIAA1024	23251	broad.mit.edu	37	15	79749274	79749274	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr15:79749274A>C	uc002bew.1	+	2	860	c.785A>C	c.(784-786)GAG>GCG	p.E262A	KIAA1024_uc010unk.1_Missense_Mutation_p.E262A	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	262						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						ATCTTCAAAGAGGATTTTCAC	0.498			NA											14	74					0	0	0.020292	0	0
SSTR5	6755	broad.mit.edu	37	16	1129350	1129350	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr16:1129350C>A	uc002ckq.2	+	1	570	c.482C>A	c.(481-483)GCC>GAC	p.A161D	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	161	Helical; Name=4; (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CTGGCGAGCGCCGCGGCCTGG	0.711			NA											4	14					0.000602214	0.000641489	0.014758	1	0
PKD1	5310	broad.mit.edu	37	16	2161139	2161139	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr16:2161139C>A	uc002cos.1	-	15	4238	c.4029G>T	c.(4027-4029)CCG>CCT	p.P1343P	PKD1_uc002cot.1_Silent_p.P1343P	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1343	PKD 8.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GTGTCACCGTCGGGCACCCCC	0.672			NA											13	22					4.3838e-07	5.01884e-07	0.105934	1	0
MYH11	4629	broad.mit.edu	37	16	15815294	15815294	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr16:15815294A>G	uc002ddy.2	-	32	4670	c.4563T>C	c.(4561-4563)GAT>GAC	p.D1521D	MYH11_uc002ddv.2_Silent_p.D1528D|MYH11_uc002ddw.2_Silent_p.D1521D|MYH11_uc002ddx.2_Silent_p.D1528D|MYH11_uc010bvg.2_Silent_p.D1353D|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Silent_p.D227D|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1521	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TGCCCACGTCATCCTTGGAGC	0.557			NA	T	CBFB	AML								30	60					0	0	0.054565	0	0
LONP2	83752	broad.mit.edu	37	16	48295479	48295479	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr16:48295479T>C	uc002efi.1	+	5	957	c.868T>C	c.(868-870)TGT>CGT	p.C290R	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.C246R	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	290					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						CCATAAAGTCTGTGTCAAAGA	0.338			NA											52	25					0	0	0.048971	0	0
NFAT5	10725	broad.mit.edu	37	16	69726354	69726354	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr16:69726354G>C	uc002exm.1	+	12	3780	c.2572G>C	c.(2572-2574)GAT>CAT	p.D858H	NFAT5_uc002exi.2_Missense_Mutation_p.D782H|NFAT5_uc002exj.1_Missense_Mutation_p.D782H|NFAT5_uc002exk.1_Missense_Mutation_p.D782H|NFAT5_uc002exl.1_Missense_Mutation_p.D876H|NFAT5_uc002exn.1_Missense_Mutation_p.D875H|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	858					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TACCAGACCAGATAATTTATT	0.348			NA											63	46					0	0	0.048971	0	0
JPH3	57338	broad.mit.edu	37	16	87678279	87678279	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr16:87678279G>T	uc002fkd.2	+	2	1052	c.798G>T	c.(796-798)CTG>CTT	p.L266L	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	266	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CCATCAGCCTGGGCGAGGCTG	0.662			NA											5	65					0.00116845	0.00123926	0.021553	1	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	23					0	0	0.069288	0	0
MYH2	4620	broad.mit.edu	37	17	10443940	10443940	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr17:10443940C>A	uc010coi.2	-	11	1107	c.979G>T	c.(979-981)GAT>TAT	p.D327Y	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.D327Y|MYH2_uc010coj.2_Missense_Mutation_p.D327Y	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	327	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTGATCATCGATGCTGGCC	0.403			NA											29	16					1.39806e-14	1.82193e-14	0.037714	1	0
SLFN11	91607	broad.mit.edu	37	17	33679953	33679953	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr17:33679953A>C	uc010ctp.2	-	7	2570	c.2128T>G	c.(2128-2130)TTG>GTG	p.L710V	SLFN11_uc010ctq.2_Missense_Mutation_p.L710V|SLFN11_uc002hjh.3_Missense_Mutation_p.L710V|SLFN11_uc002hjg.3_Missense_Mutation_p.L710V|SLFN11_uc010ctr.2_Missense_Mutation_p.L710V	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	710						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGCAATCCAAGTGGCTGGTC	0.483			NA											25	134					0	0	0.083992	0	0
KCNH6	81033	broad.mit.edu	37	17	61611300	61611300	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr17:61611300C>T	uc002jay.2	+	5	809	c.729C>T	c.(727-729)CGC>CGT	p.R243R	KCNH6_uc002jax.1_Silent_p.R243R|KCNH6_uc010wpl.1_Silent_p.R120R|KCNH6_uc010wpm.1_Silent_p.R243R|KCNH6_uc002jaz.1_Silent_p.R243R	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	243	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGGCGCCGCGCATCCACCGCT	0.672			NA											61	47					0	0	0.048971	0	0
MYOM1	8736	broad.mit.edu	37	18	3067414	3067414	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:3067414C>A	uc002klp.2	-	38	5238	c.4904G>T	c.(4903-4905)GGC>GTC	p.G1635V	MYOM1_uc002klq.2_Missense_Mutation_p.G1539V	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1635	Ig-like C2-type 5.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGTGCTCACGCCGTTGATGGT	0.592			NA											3	54					0.00909568	0.00952325	0.009096	1	0
LAMA1	284217	broad.mit.edu	37	18	7002306	7002306	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:7002306T>A	uc002knm.2	-	30	4433	c.4339A>T	c.(4339-4341)AGT>TGT	p.S1447C	LAMA1_uc010wzj.1_Missense_Mutation_p.S923C	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1447	Laminin EGF-like 15.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCACAGTCACTTGCTGAGCCA	0.577			NA											12	68					0	0	0.09319	0	0
LAMA3	3909	broad.mit.edu	37	18	21481106	21481106	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:21481106G>A	uc002kuq.2	+	48	6106	c.6020G>A	c.(6019-6021)AGG>AAG	p.R2007K	LAMA3_uc002kur.2_Missense_Mutation_p.R1951K|LAMA3_uc002kus.3_Missense_Mutation_p.R398K|LAMA3_uc002kut.3_Missense_Mutation_p.R342K	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2007	Domain II and I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACCGGATAAGGACCTGGCAG	0.438			NA											11	29					0	0	0.020292	0	0
C18orf34	374864	broad.mit.edu	37	18	30554619	30554619	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:30554619G>T	uc002kxn.2	-	21	2557	c.2415C>A	c.(2413-2415)CAC>CAA	p.H805Q	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Missense_Mutation_p.H269Q|C18orf34_uc010xbr.1_Missense_Mutation_p.H829Q|C18orf34_uc010dmf.1_Missense_Mutation_p.H125Q|C18orf34_uc002kxo.2_Missense_Mutation_p.H767Q|C18orf34_uc002kxp.2_Missense_Mutation_p.H805Q	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	805										ovary(1)	1						GCCACAGTGTGTGCATCCTTC	0.483			NA											13	13					0.000219431	0.000238936	0.020292	1	0
MYO5B	4645	broad.mit.edu	37	18	47462712	47462712	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:47462712G>C	uc002leb.2	-	16	2201	c.1913C>G	c.(1912-1914)ACC>AGC	p.T638S	MYO5B_uc002lec.1_Missense_Mutation_p.T637S	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	638	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		ATGCAGGGAGGTACGGAACTA	0.473			NA											2	14					0	0	0.004672	0	0
ALPK2	115701	broad.mit.edu	37	18	56202748	56202748	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:56202748C>T	uc002lhj.3	-	5	4885	c.4671G>A	c.(4669-4671)ACG>ACA	p.T1557T	ALPK2_uc002lhk.1_Silent_p.T888T	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1557							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TGGAGTTGTGCGTGTCAACCC	0.448			NA											52	32					0	0	0.048971	0	0
NETO1	81832	broad.mit.edu	37	18	70423324	70423324	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr18:70423324C>G	uc002lkw.2	-	8	1211	c.927G>C	c.(925-927)TTG>TTC	p.L309F	NETO1_uc002lkx.1_Missense_Mutation_p.L308F|NETO1_uc002lky.1_Missense_Mutation_p.L309F	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	309	LDL-receptor class A.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CATTGCAGACCAAAGTATTAT	0.368			NA											27	36					0	0	0.037714	0	0
STK11	6794	broad.mit.edu	37	19	1221211	1221211	+	Splice_Site	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:1221211G>T	uc002lrl.1	+	6	1850	c.735_splice	c.e6-1	p.L245_splice		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11						anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(3)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGAAATGAAGCTACAACATC	0.587			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			9	10					6.42651e-13	8.15801e-13	0.080935	1	0
MUC16	94025	broad.mit.edu	37	19	9085453	9085453	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:9085453A>C	uc002mkp.2	-	1	6566	c.6362T>G	c.(6361-6363)TTG>TGG	p.L2121W		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2121	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATCAGTGTTCAAAGTACTCGC	0.483			NA											76	51					0	0	0.048971	0	0
HAUS8	93323	broad.mit.edu	37	19	17170437	17170437	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:17170437G>T	uc002nfe.2	-	6	461	c.350C>A	c.(349-351)CCA>CAA	p.P117Q	HAUS8_uc002nff.2_Missense_Mutation_p.P116Q|HAUS8_uc002nfg.1_Missense_Mutation_p.P56Q|HAUS8_uc002nfh.1_Missense_Mutation_p.P117Q	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	117					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						TGCTAACTGTGGCGTCTTTTT	0.388			NA											21	25					2.4624e-09	2.90042e-09	0.049695	1	0
LRFN3	79414	broad.mit.edu	37	19	36430384	36430384	+	Silent	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:36430384A>C	uc002oco.2	+	2	509	c.57A>C	c.(55-57)CCA>CCC	p.P19P		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	19	Extracellular (Potential).|LRRNT.				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCTCATCCCCACCCCAGTCAG	0.711			NA											4	51					0	0	0.047766	0	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627			NA											10	15					0	0	0.043863	0	0
C19orf54	284325	broad.mit.edu	37	19	41248552	41248552	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:41248552G>A	uc002oou.1	-	6	962	c.842C>T	c.(841-843)TCC>TTC	p.S281F	C19orf54_uc002oow.1_Missense_Mutation_p.S109F|C19orf54_uc002oox.1_RNA|C19orf54_uc002ooy.1_Intron|C19orf54_uc010xvs.1_RNA	NM_198476	NP_940878	Q5BKX5	CS054_HUMAN	hypothetical protein LOC284325	281											0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGCTCCCGGGGAGCCCTCCTC	0.652			NA											12	9					0	0	0.080935	0	0
PSG3	5671	broad.mit.edu	37	19	43233396	43233396	+	Silent	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:43233396T>G	uc002oue.2	-	5	1254	c.1122A>C	c.(1120-1122)CTA>CTC	p.L374L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.L374L|PSG3_uc010eil.2_Silent_p.L396L	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	374	Ig-like C2-type 3.			Missing (in Ref. 9).	defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TTTGTCCTGATAGCTGAAACT	0.453			NA											154	127					0	0	0.048971	0	0
PSG3	5671	broad.mit.edu	37	19	43244532	43244532	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:43244532C>A	uc002oue.2	-	1	137	c.5G>T	c.(4-6)GGG>GTG	p.G2V	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Missense_Mutation_p.G24V	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	2					defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TGAGAGGGGCCCCATGGTCTC	0.607			NA											73	61					1.31311e-47	2.07556e-47	0.048971	1	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr19:58385546G>T	uc002qqo.2	-	3	1484	c.1212C>A	c.(1210-1212)GAC>GAA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGTTTTTTGTCAGTGTGAA	0.393			NA											4	7					0.00024832	0.000268011	0.009096	1	0
FAM49A	81553	broad.mit.edu	37	2	16736390	16736390	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:16736390T>G	uc010exm.1	-	10	1003	c.855A>C	c.(853-855)AAA>AAC	p.K285N	FAM49A_uc002rck.1_Missense_Mutation_p.K285N	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	285						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CCTTCAAAACTTTTATGCAGC	0.458			NA											5	24					0	0	0.02938	0	0
KIF3C	3797	broad.mit.edu	37	2	26204592	26204592	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:26204592A>G	uc002rgu.2	-	1	852	c.195T>C	c.(193-195)GAT>GAC	p.D65D	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Silent_p.D65D	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	65	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGCTGGCATCATACACGG	0.622			NA											52	93					0	0	0.048971	0	0
HNRPLL	92906	broad.mit.edu	37	2	38809125	38809125	+	Silent	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:38809125T>A	uc002rqw.2	-	6	1142	c.732A>T	c.(730-732)CCA>CCT	p.P244P	HNRPLL_uc002rqv.2_5'UTR|HNRPLL_uc002rqx.2_Silent_p.P239P	NM_138394	NP_612403	Q8WVV9	HNRLL_HUMAN	heterogeneous nuclear ribonucleoprotein L-like	244	RRM 2.				mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)				TTAGACGAGTTGGCTGTTAAG	0.328			NA											16	37					0	0	0.0333	0	0
C2orf73	129852	broad.mit.edu	37	2	54571011	54571011	+	Splice_Site	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:54571011G>T	uc002rxt.1	+	3	430	c.388_splice	c.e3+1	p.V130_splice	C2orf73_uc010yor.1_Splice_Site_p.V72_splice|C2orf73_uc002rxs.1_Splice_Site_p.V9_splice|C2orf73_uc010yos.1_Splice_Site	NM_001100396	NP_001093866	Q8N5S3	CB073_HUMAN	hypothetical protein LOC129852												0						TGTGGAATAGGTAAGGTTTTG	0.398			NA											7	15					0.00307968	0.00325225	0.038147	1	0
CCDC88A	55704	broad.mit.edu	37	2	55523591	55523591	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:55523591G>T	uc002ryv.2	-	30	5733	c.4891C>A	c.(4891-4893)CAT>AAT	p.H1631N	CCDC88A_uc010yoz.1_Missense_Mutation_p.H1604N|CCDC88A_uc010ypa.1_Missense_Mutation_p.H1631N|CCDC88A_uc002ryt.2_5'UTR|CCDC88A_uc010fbw.2_Missense_Mutation_p.H133N|CCDC88A_uc002ryu.2_Missense_Mutation_p.H886N|CCDC88A_uc002rys.2_Missense_Mutation_p.H589N|CCDC88A_uc002ryw.2_Missense_Mutation_p.H915N|CCDC88A_uc010fby.1_Missense_Mutation_p.H483N	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1632					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						CAAGCCTCATGGTCATGAAGC	0.468			NA											31	44					1.7881e-09	2.11635e-09	0.037714	1	0
DYSF	8291	broad.mit.edu	37	2	71894573	71894573	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:71894573G>T	uc002sie.2	+	47	5644	c.5268G>T	c.(5266-5268)CAG>CAT	p.Q1756H	DYSF_uc010feg.2_Missense_Mutation_p.Q1787H|DYSF_uc010feh.2_Missense_Mutation_p.Q1763H|DYSF_uc002sig.3_Missense_Mutation_p.Q1742H|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.Q1777H|DYSF_uc010fef.2_Missense_Mutation_p.Q1794H|DYSF_uc010fei.2_Missense_Mutation_p.Q1773H|DYSF_uc010fek.2_Missense_Mutation_p.Q1774H|DYSF_uc010fej.2_Missense_Mutation_p.Q1764H|DYSF_uc010fel.2_Missense_Mutation_p.Q1743H|DYSF_uc010feo.2_Missense_Mutation_p.Q1788H|DYSF_uc010fem.2_Missense_Mutation_p.Q1778H|DYSF_uc010fen.2_Missense_Mutation_p.Q1795H|DYSF_uc002sif.2_Missense_Mutation_p.Q1757H|DYSF_uc010yqy.1_Missense_Mutation_p.Q637H|DYSF_uc010yqz.1_Missense_Mutation_p.Q517H	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1756	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ATGTGCTTCAGCAGCAGGGCC	0.627			NA											46	57					3.05275e-18	4.15513e-18	0.045515	1	0
ITPRIPL1	150771	broad.mit.edu	37	2	96993360	96993360	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:96993360G>C	uc002svx.2	+	3	1326	c.991G>C	c.(991-993)GCC>CCC	p.A331P	ITPRIPL1_uc010yuk.1_Missense_Mutation_p.A323P|ITPRIPL1_uc002svy.2_Missense_Mutation_p.A339P|ITPRIPL1_uc010yul.1_Missense_Mutation_p.A323P	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	331	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						CAATGCCTGGGCCCTTGTGGC	0.557			NA											31	53					0	0	0.037714	0	0
AFF3	3899	broad.mit.edu	37	2	100623170	100623170	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:100623170C>A	uc002tag.2	-	6	1033	c.797G>T	c.(796-798)GGA>GTA	p.G266V	AFF3_uc002taf.2_Missense_Mutation_p.G291V|AFF3_uc010fiq.1_Missense_Mutation_p.G266V|AFF3_uc010yvr.1_Missense_Mutation_p.G420V|AFF3_uc002tah.1_Missense_Mutation_p.G291V|AFF3_uc010fir.1_Missense_Mutation_p.G343V|AFF3_uc002tai.2_Missense_Mutation_p.G188V	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	266					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGCAGGGACTCCCCTGTATGA	0.582			NA											28	31					3.65163e-15	4.83594e-15	0.030593	1	0
IL18RAP	8807	broad.mit.edu	37	2	103061734	103061734	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:103061734G>T	uc002tbx.2	+	9	1490	c.1006G>T	c.(1006-1008)GTT>TTT	p.V336F	IL18RAP_uc010fiz.2_Missense_Mutation_p.V194F	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	336	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						CAGGAAGTTTGTTTGCTTTGT	0.428			NA											23	45					1.36565e-18	1.86918e-18	0.076483	1	0
PAX8	7849	broad.mit.edu	37	2	114002029	114002029	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:114002029C>A	uc010yxt.1	-	4	530	c.364G>T	c.(364-366)GTG>TTG	p.V122L	PAX8_uc010yxu.1_Missense_Mutation_p.V122L|PAX8_uc010yxv.1_Missense_Mutation_p.V122L|PAX8_uc002tjm.2_Missense_Mutation_p.V122L|PAX8_uc002tjn.2_Missense_Mutation_p.V122L|PAX8_uc010fku.1_Missense_Mutation_p.V122L|LOC654433_uc002tjq.3_Intron|LOC654433_uc010fks.2_Intron|LOC654433_uc010fkt.2_Intron|LOC654433_uc002tjr.3_Intron	NM_003466	NP_003457	Q06710	PAX8_HUMAN	paired box 8 isoform PAX8A	122	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity			ovary(1)|lung(1)	2						ACACTGGGCACAGTGTCATTG	0.552	Ovarian(188;7 2067 9084 29802 29892)		NA	T	PPARG	follicular thyroid		Thyroid dysgenesis 						53	196					2.81731e-22	3.98983e-22	0.048971	1	0
GLI2	2736	broad.mit.edu	37	2	121726411	121726411	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:121726411G>T	uc010flp.2	+	5	795	c.765G>T	c.(763-765)TCG>TCT	p.S255S	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Missense_Mutation_p.A126S|GLI2_uc010flo.1_Silent_p.S130S|GLI2_uc002tmw.1_Silent_p.S255S	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	255					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CACCCAACTCGCTAGTGGCCT	0.672			NA											25	57					5.35356e-11	6.46119e-11	0.076483	1	0
MYO7B	4648	broad.mit.edu	37	2	128324229	128324229	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:128324229C>T	uc002top.2	+	5	350	c.297C>T	c.(295-297)GGC>GGT	p.G99G		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	99	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CATACACAGGCTCCATCCTGG	0.652			NA											4	15					0	0	0.014758	0	0
POTEF	728378	broad.mit.edu	37	2	130877719	130877719	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:130877719C>T	uc010fmh.2	-	3	770	c.370G>A	c.(370-372)GAT>AAT	p.D124N		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	124						cell cortex	ATP binding			skin(3)|ovary(2)	5						GCACTGTCATCGTAGTCTCCC	0.577			NA											82	110					0	0	0.048971	0	0
CFC1B	653275	broad.mit.edu	37	2	131356257	131356257	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:131356257C>A	uc002tro.1	-	3	596	c.205G>T	c.(205-207)GGG>TGG	p.G69W		NM_001079530	NP_001072998	P0CG36	CFC1B_HUMAN	cripto, FRL-1, cryptic family 1B	69					gastrulation	extracellular region					0	Colorectal(110;0.1)					TCCTCCGGCCCCCAGCCCTCG	0.627			NA											16	89					2.21704e-12	2.75723e-12	0.076483	1	0
FAM123C	205147	broad.mit.edu	37	2	131520357	131520357	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:131520357G>T	uc002trw.2	+	2	902	c.712G>T	c.(712-714)GTG>TTG	p.V238L	FAM123C_uc010fmv.2_Missense_Mutation_p.V238L|FAM123C_uc010fms.1_Missense_Mutation_p.V238L|FAM123C_uc010fmt.1_Missense_Mutation_p.V238L|FAM123C_uc010fmu.1_Missense_Mutation_p.V238L	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	238										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GTGTGAGGACGTGGCCTCACT	0.657			NA											41	52					2.58029e-29	3.92652e-29	0.11126	1	0
XIRP2	129446	broad.mit.edu	37	2	168105645	168105645	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:168105645A>G	uc002udx.2	+	8	7761	c.7743A>G	c.(7741-7743)ACA>ACG	p.T2581T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.T2406T|XIRP2_uc010fpq.2_Silent_p.T2359T|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2406					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AACACATAACAGAGGTGGAAA	0.368			NA											44	81					0	0	0.039052	0	0
HOXD12	3238	broad.mit.edu	37	2	176964707	176964708	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:176964707_176964708CC>AA	uc010zev.1	+	1	178_179	c.178_179CC>AA	c.(178-180)CCC>AAC	p.P60N	HOXD12_uc010zew.1_Missense_Mutation_p.P60N	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	60						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CTCCTGCGCCCCCGCGCAGCCT	0.748			NA											10	18					0	0	0.004672	0	0
FAM171B	165215	broad.mit.edu	37	2	187627205	187627205	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:187627205T>A	uc002ups.2	+	8	2248	c.2136T>A	c.(2134-2136)AAT>AAA	p.N712K	FAM171B_uc002upr.1_Missense_Mutation_p.N679K|FAM171B_uc002upt.2_Missense_Mutation_p.N181K	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	712	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						TGGACATGAATGAGCTTCACT	0.458			NA											22	60					0	0	0.062417	0	0
STAT4	6775	broad.mit.edu	37	2	191934452	191934452	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:191934452A>T	uc002usm.1	-	6	765	c.511T>A	c.(511-513)TTT>ATT	p.F171I	STAT4_uc002usn.1_Missense_Mutation_p.F171I|STAT4_uc010zgk.1_Missense_Mutation_p.F16I|STAT4_uc002uso.2_Missense_Mutation_p.F171I	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	171					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			CTGTAGTCAAATTCGTCTTGC	0.328			NA											28	110					0	0	0.041601	0	0
DNAH7	56171	broad.mit.edu	37	2	196750928	196750928	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:196750928A>G	uc002utj.3	-	34	5576	c.5475T>C	c.(5473-5475)GAT>GAC	p.D1825D		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1825					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CAGCAAAATCATCCATAAAAC	0.373			NA											20	66					0	0	0.055883	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657796	197657796	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:197657796C>T	uc002uts.2	-	3	385	c.295G>A	c.(295-297)GAA>AAA	p.E99K	GTF3C3_uc010zgu.1_Missense_Mutation_p.E99K|GTF3C3_uc002utu.2_Missense_Mutation_p.E99K	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	99	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						tcttcctcttcctcctcATCA	0.343			NA											22	30					0	0	0.055883	0	0
SATB2	23314	broad.mit.edu	37	2	200137136	200137136	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:200137136C>A	uc002uuy.1	-	11	2817	c.2000G>T	c.(1999-2001)CGG>CTG	p.R667L	SATB2_uc010fsq.1_Missense_Mutation_p.R549L|SATB2_uc002uuz.1_Missense_Mutation_p.R667L|SATB2_uc002uva.1_Missense_Mutation_p.R667L	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	667	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CACGTGGTACCGCTGGTTCTG	0.567	Colon(30;262 767 11040 24421 36230)		NA											27	88					1.38854e-25	2.03708e-25	0.037714	1	0
ALS2CR8	79800	broad.mit.edu	37	2	203846375	203846375	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:203846375C>T	uc002uzo.2	+	14	1936	c.1656C>T	c.(1654-1656)TCC>TCT	p.S552S	ALS2CR8_uc010zia.1_Silent_p.S476S|ALS2CR8_uc010zib.1_Silent_p.S476S|ALS2CR8_uc010zic.1_Silent_p.S464S|ALS2CR8_uc002uzp.2_Silent_p.S552S	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	552										large_intestine(1)|ovary(1)	2						CCTCACTCTCCTCATTTCAGC	0.413			NA											36	76					0	0	0.080422	0	0
TNP1	7141	broad.mit.edu	37	2	217724654	217724654	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:217724654T>A	uc002vgk.2	-	1	129	c.104A>T	c.(103-105)AAG>ATG	p.K35M		NM_003284	NP_003275	P09430	STP1_HUMAN	transition protein 1 (during histone to	35					chromatin silencing|fertilization, exchange of chromosomal proteins|multicellular organismal development|nucleosome disassembly|single strand break repair|sperm motility|spermatid nucleus elongation	nucleosome	DNA binding				0		Renal(207;0.0822)		Epithelial(149;8.97e-07)|all cancers(144;2.46e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGGTTGCCCTTACGGTATTT	0.532			NA											39	111					0	0	0.104719	0	0
ATG9A	79065	broad.mit.edu	37	2	220087499	220087499	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr2:220087499C>T	uc002vke.1	-	11	1902	c.1716G>A	c.(1714-1716)GAG>GAA	p.E572E	ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Silent_p.E572E	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	572	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGCTGTGCTCTCACGTGGTG	0.572			NA											37	90					0	0	0.074837	0	0
JPH2	57158	broad.mit.edu	37	20	42788302	42788302	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr20:42788302G>T	uc002xli.1	-	2	1998	c.1125C>A	c.(1123-1125)CGC>CGA	p.R375R		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	375	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TAGCAGCGGCGCGCTGGGCAC	0.667			NA											13	31					1.5739e-10	1.89022e-10	0.028581	1	0
MMP9	4318	broad.mit.edu	37	20	44640804	44640804	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr20:44640804G>T	uc002xqz.2	+	7	1045	c.1026G>T	c.(1024-1026)TCG>TCT	p.S342S		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	342	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GGGGCAACTCGGCGGGGGAGC	0.632			NA											49	100					3.50607e-19	4.85303e-19	0.048971	1	0
PREX1	57580	broad.mit.edu	37	20	47265961	47265961	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr20:47265961T>A	uc002xtw.1	-	25	3205	c.3182A>T	c.(3181-3183)GAC>GTC	p.D1061V	PREX1_uc002xtv.1_Missense_Mutation_p.D358V	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1061					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GAGGCCCCGGTCTTCCTGACC	0.612			NA											27	60					0	0	0.041601	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874246	31874246	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr21:31874246A>G	uc011ada.1	-	1	163	c.163T>C	c.(163-165)TAC>CAC	p.Y55H		NM_181611	NP_853642	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	55						intermediate filament	protein binding				0						CAGCTGCGGTATCCATAGCCT	0.532			NA											59	164					0	0	0.048971	0	0
GCFC1	94104	broad.mit.edu	37	21	34132126	34132126	+	Silent	SNP	G	G	A	rs144407550		TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr21:34132126G>A	uc002yqn.2	-	6	1345	c.1155C>T	c.(1153-1155)CCC>CCT	p.P385P	GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Silent_p.P385P|GCFC1_uc002yqr.2_Silent_p.P385P	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	385						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						CAATAGTAACGGGAGTCATCT	0.408			NA											85	144					0	0	0.048971	0	0
KCNE1	3753	broad.mit.edu	37	21	35821633	35821633	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr21:35821633C>A	uc010gmp.2	-	2	730	c.300G>T	c.(298-300)CTG>CTT	p.L100L	KCNE1_uc002ytz.2_Silent_p.L100L|KCNE1_uc010gmq.2_Silent_p.L100L|KCNE1_uc010gmr.2_Silent_p.L100L|KCNE1_uc010gms.2_Silent_p.L100L|KCNE1_uc002yua.2_RNA	NM_001127670	NP_001121142	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related	100	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(2)	2					Indapamide(DB00808)	TGTAGCTCTCCAGGACCCGGG	0.557			NA											63	120					1.53716e-24	2.21531e-24	0.048971	1	0
ADARB1	104	broad.mit.edu	37	21	46596226	46596226	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr21:46596226G>T	uc002zgy.2	+	4	1045	c.610G>T	c.(610-612)GGG>TGG	p.G204W	ADARB1_uc002zgr.2_Missense_Mutation_p.G204W|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Missense_Mutation_p.G204W|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Missense_Mutation_p.G204W|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Missense_Mutation_p.G253W	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	204					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		CAGTTCCAGCGGGGACCTCAG	0.592			NA											18	40					5.3912e-06	6.05892e-06	0.038395	1	0
COL6A2	1292	broad.mit.edu	37	21	47535957	47535957	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr21:47535957C>G	uc002zia.1	+	7	972	c.890C>G	c.(889-891)CCA>CGA	p.P297R	COL6A2_uc002zhy.1_Missense_Mutation_p.P297R|COL6A2_uc002zhz.1_Missense_Mutation_p.P297R|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	297	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ATTGGATTCCCAGGACCCAAG	0.711			NA											4	6					0	0	0.009096	0	0
EFCAB6	64800	broad.mit.edu	37	22	43930600	43930600	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr22:43930600G>C	uc003bdy.1	-	30	4416	c.4201C>G	c.(4201-4203)CAC>GAC	p.H1401D	EFCAB6_uc003bdz.1_Missense_Mutation_p.H1249D|EFCAB6_uc010gzi.1_Missense_Mutation_p.H1249D	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1401	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				TTCATCCTGTGCATCAGTGAG	0.423			NA											12	21					0	0	0.105934	0	0
LRPAP1	4043	broad.mit.edu	37	4	3521828	3521828	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr4:3521828C>A	uc003ghi.2	-	3	527	c.442G>T	c.(442-444)GAC>TAC	p.D148Y		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	148					negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		AGCCTGGGGTCATCCAGCCCG	0.552			NA											17	67					5.35267e-07	6.09955e-07	0.043863	1	0
SLIT2	9353	broad.mit.edu	37	4	20570575	20570575	+	Silent	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr4:20570575A>T	uc003gpr.1	+	29	3240	c.3036A>T	c.(3034-3036)ACA>ACT	p.T1012T	SLIT2_uc003gps.1_Silent_p.T1004T	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1012	EGF-like 3; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATAATTCTACATGTGTCGATG	0.363			NA											40	56					0	0	0.074837	0	0
CCKAR	886	broad.mit.edu	37	4	26483656	26483656	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr4:26483656C>A	uc003gse.1	-	5	1044	c.891G>T	c.(889-891)CGG>CGT	p.R297R		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	297	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	AGCTGTTACTCCGGATGCGGT	0.602			NA											56	101					5.22555e-25	7.6206e-25	0.048971	1	0
FRYL	285527	broad.mit.edu	37	4	48555252	48555252	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr4:48555252T>C	uc003gyh.1	-	36	5020	c.4415A>G	c.(4414-4416)AAA>AGA	p.K1472R	FRYL_uc003gyk.2_Missense_Mutation_p.K1472R|FRYL_uc003gyg.1_Missense_Mutation_p.K168R|FRYL_uc003gyi.1_Missense_Mutation_p.K361R	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1472					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AGAAGGGATTTTATAGCTGGA	0.338			NA											24	54					0	0	0.099896	0	0
NDST4	64579	broad.mit.edu	37	4	115760697	115760697	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr4:115760697C>A	uc003ibu.2	-	11	2802	c.2123G>T	c.(2122-2124)CGA>CTA	p.R708L	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	708	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TTCATGTGATCGTTGGTGCTT	0.279			NA											31	20					9.65021e-13	1.21246e-12	0.045705	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5191905	5191905	+	Splice_Site	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:5191905T>G	uc003jdl.2	+	8	1451	c.1313_splice	c.e8+2	p.N438_splice	ADAMTS16_uc003jdk.1_Splice_Site_p.N438_splice|ADAMTS16_uc003jdj.1_Splice_Site_p.N438_splice	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TGGACACAAGTAAGTGCATCT	0.443			NA											47	75					0	0	0.048971	0	0
PAPD7	11044	broad.mit.edu	37	5	6753049	6753049	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:6753049G>T	uc003jdx.1	+	12	1462	c.1333G>T	c.(1333-1335)GTA>TTA	p.V445L	PAPD7_uc011cmn.1_Missense_Mutation_p.V436L|PAPD7_uc010itl.1_Missense_Mutation_p.V265L	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	445					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						ACAAGCTGGTGTAGAAGGAAC	0.542	NSCLC(7;212 333 5667 23379 46547)		NA											50	94					5.82388e-19	8.01602e-19	0.048971	1	0
CDH10	1008	broad.mit.edu	37	5	24511448	24511448	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:24511448G>C	uc003jgr.1	-	6	1322	c.990C>G	c.(988-990)ATC>ATG	p.I330M	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	330	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TTTTCACAGTGATGATGCCTT	0.413			NA								HNSCC(23;0.051)			58	152					0	0	0.048971	0	0
DAB2	1601	broad.mit.edu	37	5	39377150	39377150	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:39377150G>A	uc003jlx.2	-	12	2270	c.1739C>T	c.(1738-1740)GCA>GTA	p.A580V	DAB2_uc003jlw.2_Missense_Mutation_p.A559V	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	580					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			AGCATTGGGTGCCACAGATGC	0.547			NA									OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	80					0	0	0.048971	0	0
DAB2	1601	broad.mit.edu	37	5	39383033	39383033	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:39383033A>G	uc003jlx.2	-	10	1559	c.1028T>C	c.(1027-1029)TTT>TCT	p.F343S	DAB2_uc003jlw.2_Missense_Mutation_p.F322S	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	343					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			TTGCTGACCAAAGTAGTCAAC	0.493			NA											6	115					0	0	0.021553	0	0
HCN1	348980	broad.mit.edu	37	5	45303793	45303793	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:45303793C>A	uc003jok.2	-	6	1551	c.1526G>T	c.(1525-1527)GGT>GTT	p.G509V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	509	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CATTTTTTTACCCACGGCTCC	0.398			NA											42	83					3.54909e-21	4.99728e-21	0.042209	1	0
EDIL3	10085	broad.mit.edu	37	5	83259126	83259126	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:83259126T>G	uc003kio.1	-	10	1610	c.1191A>C	c.(1189-1191)AAA>AAC	p.K397N	EDIL3_uc003kip.1_Missense_Mutation_p.K387N	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	397	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GACCAAAATCTTTAGCTCCTT	0.383			NA											13	44					0	0	0.09319	0	0
CAMK4	814	broad.mit.edu	37	5	110819995	110819995	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:110819995C>A	uc011cvj.1	+	12	1352	c.1253C>A	c.(1252-1254)CCC>CAC	p.P418H	CAMK4_uc003kpf.2_Missense_Mutation_p.P418H|CAMK4_uc010jbv.2_Missense_Mutation_p.P221H|CAMK4_uc003kpg.2_Missense_Mutation_p.P109H	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	418					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AAAATGGTGCCCAAGGCAGTG	0.547			NA											29	15					9.65021e-13	1.21246e-12	0.045705	1	0
PCDHB7	56129	broad.mit.edu	37	5	140552500	140552500	+	Silent	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:140552500C>A	uc003lit.2	+	1	258	c.84C>A	c.(82-84)GCC>GCA	p.A28A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	28	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCTGGCGCCGAACCGCTTC	0.517			NA											45	31					7.77092e-38	1.20498e-37	0.048971	1	0
PCDHB11	56125	broad.mit.edu	37	5	140579566	140579566	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:140579566G>T	uc003liy.2	+	1	219	c.219G>T	c.(217-219)CAG>CAT	p.Q73H	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	73	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAAGAAACAGCGTTTGCAGC	0.527			NA											69	35					1.65906e-26	2.46345e-26	0.048971	1	0
PANK3	79646	broad.mit.edu	37	5	167995679	167995679	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:167995679G>C	uc003lzz.1	-	2	653	c.353C>G	c.(352-354)GCT>GGT	p.A118G		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	118					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		AAACTTGTAAGCACCACCTCC	0.383			NA											58	50					0	0	0.048971	0	0
RANBP17	64901	broad.mit.edu	37	5	170667972	170667972	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:170667972G>T	uc003mba.2	+	23	2479	c.2463G>T	c.(2461-2463)CAG>CAT	p.Q821H	RANBP17_uc003mbb.2_Missense_Mutation_p.Q146H|RANBP17_uc003mbd.2_Missense_Mutation_p.Q184H|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	821					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAAAAGATCAGATTTATCCAA	0.413			NA	T	TRD@	ALL								79	65					3.00167e-28	4.53957e-28	0.048971	1	0
STC2	8614	broad.mit.edu	37	5	172755169	172755169	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:172755169T>C	uc003mco.1	-	1	1338	c.28A>G	c.(28-30)ATG>GTG	p.M10V	STC2_uc003mcn.1_5'Flank	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	10					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCCAGGGTCATGAACTGGCCC	0.557			NA											54	37					0	0	0.048971	0	0
SLC34A1	6569	broad.mit.edu	37	5	176825246	176825246	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:176825246C>A	uc003mgk.3	+	13	1980	c.1879C>A	c.(1879-1881)CGT>AGT	p.R627S		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	627	Cytoplasmic (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCCTCCCCCCGTCTTGCACT	0.692			NA											23	6					2.70639e-06	3.06975e-06	0.069288	1	0
FAM50B	26240	broad.mit.edu	37	6	3850329	3850329	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr6:3850329A>G	uc003mvu.2	+	2	396	c.284A>G	c.(283-285)GAG>GGG	p.E95G		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	95						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				CAGCACCTGGAGGagcagcgg	0.512			NA											9	3					0	0	0.047766	0	0
HLA-J	3137	broad.mit.edu	37	6	29976906	29976906	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr6:29976906C>T	uc003rtl.3	+	3	596	c.234C>T	c.(232-234)GAC>GAT	p.D78D	HLA-G_uc011dmb.1_Intron|NCRNA00171_uc011dme.1_Intron|HLA-J_uc003nou.3_RNA|HLA-J_uc003nov.3_RNA					Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:4694038).												0						TCTCACAGGACGTTTTCTTCC	0.507			NA											34	43					0	0	0.064281	0	0
ZNF451	26036	broad.mit.edu	37	6	56989619	56989619	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr6:56989619G>A	uc003pdm.1	+	4	498	c.274G>A	c.(274-276)GAG>AAG	p.E92K	ZNF451_uc003pdl.2_Missense_Mutation_p.E92K|ZNF451_uc003pdn.1_Missense_Mutation_p.E92K|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.E92K	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TGTTGAAGTGGAGAAACAGCA	0.303			NA											7	19					0	0	0.058154	0	0
ZNF451	26036	broad.mit.edu	37	6	56989634	56989634	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr6:56989634G>T	uc003pdm.1	+	4	513	c.289G>T	c.(289-291)GAA>TAA	p.E97*	ZNF451_uc003pdl.2_Nonsense_Mutation_p.E97*|ZNF451_uc003pdn.1_Nonsense_Mutation_p.E97*|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Nonsense_Mutation_p.E97*	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ACAGCAGAAAGAAGAGAAGAA	0.303			NA											7	17					0.00448238	0.00471323	0.047766	1	0
ENPP1	5167	broad.mit.edu	37	6	132189226	132189226	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr6:132189226C>A	uc011ecf.1	+	12	1253	c.1233C>A	c.(1231-1233)AAC>AAA	p.N411K	ENPP1_uc003qcy.2_Missense_Mutation_p.N41K	NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	411	Phosphodiesterase.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	AAGAGCTGAACTTGCACAGAT	0.408	Colon(104;336 1535 5856 11019 33782)		NA											56	47					4.96213e-28	7.45842e-28	0.048971	1	0
RNF216	54476	broad.mit.edu	37	7	5751409	5751409	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:5751409T>A	uc003soy.1	-	13	2063	c.1873A>T	c.(1873-1875)AAT>TAT	p.N625Y	RNF216_uc010ksz.1_Missense_Mutation_p.N247Y|RNF216_uc010kta.1_Missense_Mutation_p.N247Y|RNF216_uc011jwj.1_Missense_Mutation_p.N247Y|RNF216_uc003sox.1_Missense_Mutation_p.N682Y	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	625	IBR-type.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CAGTGAGGATTAGGACAGCTG	0.453			NA											10	33					0	0	0.058154	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6080534	6080534	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:6080534C>A	uc003spp.2	-	9	1254	c.1108G>T	c.(1108-1110)GGT>TGT	p.G370C	EIF2AK1_uc003spq.2_Missense_Mutation_p.G369C|EIF2AK1_uc011jwm.1_Missense_Mutation_p.G246C|EIF2AK1_uc003spr.1_Missense_Mutation_p.G162C	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	370	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TCTGTCTGACCCAAAAAGTTG	0.498			NA											32	100					2.08457e-15	2.79082e-15	0.045705	1	0
HOXA10	3206	broad.mit.edu	37	7	27213851	27213851	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:27213851G>T	uc011jzm.1	-	1	105	c.75C>A	c.(73-75)GCC>GCA	p.A25A	HOXA10_uc003syw.3_Intron	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	25					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGAGTTCGCGGCGGGGCTCT	0.418			NA											51	34					1.59911e-31	2.44864e-31	0.048971	1	0
ZNF679	168417	broad.mit.edu	37	7	63721249	63721249	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:63721249G>A	uc003tsx.2	+	4	473	c.204G>A	c.(202-204)CTG>CTA	p.L68L		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	68	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCACCTGTCTGGAGCAAAATA	0.378			NA											10	42					0	0	0.069234	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73944212	73944212	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:73944212G>A	uc003uaq.2	+	9	1632	c.1239G>A	c.(1237-1239)CTG>CTA	p.L413L	GTF2IRD1_uc010lbq.2_Silent_p.L445L|GTF2IRD1_uc003uap.2_Silent_p.L413L|GTF2IRD1_uc003uar.1_Silent_p.L413L	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	413	GTF2I-like 2.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						AGCGGATCCTGGAGGAGCGCC	0.428			NA											11	20					0	0	0.080935	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964140	88964140	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:88964140A>T	uc011khi.1	+	4	2382	c.1844A>T	c.(1843-1845)AAG>ATG	p.K615M		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	615						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GGCTGCAGAAAGGCAGTTCTA	0.388			NA								HNSCC(36;0.09)			16	59					0	0	0.038395	0	0
MUC17	140453	broad.mit.edu	37	7	100681471	100681471	+	Silent	SNP	T	T	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:100681471T>G	uc003uxp.1	+	3	6827	c.6774T>G	c.(6772-6774)ACT>ACG	p.T2258T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2258	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|36.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGAAGCCACTTCATCTCCTA	0.502			NA											83	481					0	0	0.048971	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839371	100839371	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:100839371G>T	uc003uyc.2	-	7	1049	c.882C>A	c.(880-882)CCC>CCA	p.P294P	MOGAT3_uc010lhr.2_Missense_Mutation_p.H227N	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	294					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GGACGGGGATGGGGCGGCCCA	0.682			NA											9	9					0.000274275	0.000294725	0.047766	1	0
DLD	1738	broad.mit.edu	37	7	107542810	107542810	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:107542810G>T	uc003vet.2	+	4	349	c.239G>T	c.(238-240)TGC>TTC	p.C80F	DLD_uc010ljm.1_RNA|DLD_uc011kmg.1_Missense_Mutation_p.C80F|DLD_uc011kmh.1_Intron|DLD_uc011kmi.1_Intron	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor	80	FAD.				branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	GGTGGAACATGCTTGAATGTT	0.368			NA											20	71					1.96895e-08	2.29711e-08	0.076483	1	0
NRCAM	4897	broad.mit.edu	37	7	107808783	107808783	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:107808783G>A	uc003vfb.2	-	29	3723	c.3252C>T	c.(3250-3252)ATC>ATT	p.I1084I	NRCAM_uc003vfc.2_Intron|NRCAM_uc011kmk.1_Intron|NRCAM_uc003vfd.2_Intron|NRCAM_uc003vfe.2_Intron|NRCAM_uc011kmj.1_Intron	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	1084	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						ATTCCCAACTGATATTGGCAT	0.378			NA											23	33					0	0	0.076483	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117432175	117432175	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:117432175G>C	uc003vjf.2	-	4	1167	c.1075C>G	c.(1075-1077)CAG>GAG	p.Q359E		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	359										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TAGGAAGCCTGCCTGTCAATA	0.522			NA											25	89					0	0	0.083992	0	0
CPA4	51200	broad.mit.edu	37	7	129948207	129948207	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:129948207C>A	uc003vpr.2	+	8	810	c.763C>A	c.(763-765)CCA>ACA	p.P255T	CPA4_uc011kpd.1_Missense_Mutation_p.P222T|CPA4_uc011kpe.1_Missense_Mutation_p.P151T	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	255					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TGGTGCTGACCCAAATAGAAA	0.547			NA											26	38					4.59853e-10	5.46912e-10	0.108266	1	0
PLXNA4	91584	broad.mit.edu	37	7	131895838	131895838	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:131895838G>A	uc003vra.3	-	10	2391	c.2162C>T	c.(2161-2163)ACG>ATG	p.T721M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	721	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGCCTTCAGCGTGATAGGCTT	0.652			NA											8	4					0	0	0.038147	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490255	141490255	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:141490255T>A	uc003vwr.1	+	1	239	c.94T>A	c.(94-96)TTT>ATT	p.F32I		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	32	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					GGTCTGGAGTTTTAGAGAATG	0.498			NA											39	42					0	0	0.074837	0	0
OR9A4	130075	broad.mit.edu	37	7	141619370	141619370	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:141619370C>T	uc003vwu.1	+	1	695	c.695C>T	c.(694-696)TCT>TTT	p.S232F		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CCGTCATCCTCTGGCCGGAGG	0.483			NA											23	123					0	0	0.062417	0	0
OR2A12	346525	broad.mit.edu	37	7	143792488	143792488	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:143792488C>T	uc011kty.1	+	1	288	c.288C>T	c.(286-288)TGC>TGT	p.C96C		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TTGCTCCTTGCATACTTCAGA	0.443			NA											22	105					0	0	0.076483	0	0
OR2A14	135941	broad.mit.edu	37	7	143826991	143826991	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:143826991G>T	uc011kua.1	+	1	786	c.786G>T	c.(784-786)AAG>AAT	p.K262N		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TGGCCCCCAAGTCCCGCCATC	0.552			NA											7	206					8.12818e-05	8.93007e-05	0.02938	1	0
NOBOX	135935	broad.mit.edu	37	7	144098578	144098578	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:144098578G>T	uc011kue.1	-	4	405	c.405C>A	c.(403-405)TGC>TGA	p.C135*		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	135					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CTGAGATGGTGCAGGAGGGTG	0.667			NA											27	38					3.73148e-12	4.57106e-12	0.034045	1	0
REPIN1	29803	broad.mit.edu	37	7	150069074	150069074	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:150069074G>A	uc010lpq.1	+	4	1233	c.744G>A	c.(742-744)AAG>AAA	p.K248K	REPIN1_uc003whd.2_Silent_p.K237K|REPIN1_uc010lpr.1_Silent_p.K305K|REPIN1_uc003whc.2_Silent_p.K248K|REPIN1_uc003whe.2_Silent_p.K248K	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	248	C2H2-type 6.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			TCCGGCACAAGCCCAACTTGA	0.517			NA											27	32					0	0	0.041601	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417443	150417443	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:150417443G>A	uc003whq.2	+	3	438	c.351G>A	c.(349-351)CTG>CTA	p.L117L	GIMAP1_uc003whp.2_Silent_p.L125L	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	117	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCTGCTCCTGGTGACCCAGT	0.617			NA											24	31					0	0	0.076483	0	0
DPP6	1804	broad.mit.edu	37	7	154564630	154564630	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr7:154564630C>A	uc003wlk.2	+	10	1243	c.1114C>A	c.(1114-1116)CCG>ACG	p.P372T	DPP6_uc003wli.2_Missense_Mutation_p.P308T|DPP6_uc003wlm.2_Missense_Mutation_p.P310T|DPP6_uc011kvq.1_Missense_Mutation_p.P265T	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	372	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity	p.E372Q(1)		pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GGAGATGATGCCGCCTGATGA	0.438	NSCLC(125;1384 1783 2490 7422 34254)		NA											7	27					0.000157383	0.000172138	0.038147	1	0
GFRA2	2675	broad.mit.edu	37	8	21608281	21608281	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:21608281G>T	uc003wzu.1	-	4	1288	c.613C>A	c.(613-615)CGC>AGC	p.R205S	GFRA2_uc003wzv.1_Missense_Mutation_p.R100S|GFRA2_uc003wzw.1_Missense_Mutation_p.R72S|DOK2_uc003wzx.1_Intron	NM_001495	NP_001486	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2 isoform a	205						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		AAGAACTGGCGCAGGGCCTTG	0.637			NA											52	72					1.57914e-17	2.13752e-17	0.048971	1	0
SNAI2	6591	broad.mit.edu	37	8	49832880	49832880	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:49832880G>T	uc003xqp.2	-	2	364	c.200C>A	c.(199-201)GCC>GAC	p.A67D		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	67					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				GGGTAGCTGGGCGTGGAATGG	0.557			NA											55	123					9.52127e-25	1.3803e-24	0.048971	1	0
DNAJC5B	85479	broad.mit.edu	37	8	67012241	67012241	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:67012241C>G	uc003xvs.1	+	6	866	c.575C>G	c.(574-576)TCT>TGT	p.S192C	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	192					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			AAAGAAGGATCTCGAAGTTAT	0.428			NA											12	35					0	0	0.09319	0	0
DNAJC5B	85479	broad.mit.edu	37	8	67012245	67012245	+	Silent	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:67012245A>G	uc003xvs.1	+	6	870	c.579A>G	c.(577-579)CGA>CGG	p.R193R	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	193					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			AAGGATCTCGAAGTTATTGCA	0.438			NA											11	36					0	0	0.080935	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619930	77619930	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:77619930T>A	uc003yav.2	+	3	3049	c.2662T>A	c.(2662-2664)TCT>ACT	p.S888T	ZFHX4_uc003yat.1_Missense_Mutation_p.S888T|ZFHX4_uc003yau.1_Missense_Mutation_p.S914T|ZFHX4_uc003yaw.1_Missense_Mutation_p.S888T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	888						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAATTCACCTCTGACAGCCT	0.522			NA								HNSCC(33;0.089)			15	33					0	0	0.038395	0	0
SLC26A7	115111	broad.mit.edu	37	8	92261960	92261960	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:92261960G>T	uc003yex.2	+	3	359	c.81G>T	c.(79-81)TGG>TGT	p.W27C	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.W27C|SLC26A7_uc003yfa.2_Missense_Mutation_p.W27C	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	27	Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTATACAGTGGTGTAGAAGGC	0.428			NA											29	67					2.12542e-12	2.65677e-12	0.030593	1	0
CSMD3	114788	broad.mit.edu	37	8	113569034	113569034	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:113569034C>A	uc003ynu.2	-	25	4351	c.4192G>T	c.(4192-4194)GGG>TGG	p.G1398W	CSMD3_uc003yns.2_Missense_Mutation_p.G670W|CSMD3_uc003ynt.2_Missense_Mutation_p.G1358W|CSMD3_uc011lhx.1_Missense_Mutation_p.G1294W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1398	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTCTCTCCCCTGTCATGCAC	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	58					2.14196e-07	2.47537e-07	0.034045	1	0
TRPS1	7227	broad.mit.edu	37	8	116599310	116599310	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:116599310C>A	uc003ynz.2	-	4	3038	c.2579G>T	c.(2578-2580)GGA>GTA	p.G860V	TRPS1_uc011lhy.1_Missense_Mutation_p.G864V|TRPS1_uc003yny.2_Missense_Mutation_p.G873V|TRPS1_uc010mcy.2_Missense_Mutation_p.G860V	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	860					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGACTTCTCTCCGCCAGCTGG	0.567			NA							Langer-Giedion_syndrome				39	67					4.00102e-26	5.90512e-26	0.086207	1	0
CYP11B2	1585	broad.mit.edu	37	8	143994294	143994294	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:143994294G>C	uc003yxk.1	-	7	1132	c.1129C>G	c.(1129-1131)CCT>GCT	p.P377A		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	377					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	AGACCCACAGGGTAGAGCCTG	0.602			NA							Familial_Hyperaldosteronism_type_I				14	19					0	0	0.024245	0	0
TSTA3	7264	broad.mit.edu	37	8	144696379	144696379	+	Silent	SNP	C	C	A	rs144331064	by1000genomes	TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:144696379C>A	uc003yza.2	-	7	654	c.618G>T	c.(616-618)ACG>ACT	p.T206T	TSTA3_uc003yzb.2_Silent_p.T206T	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	206					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	TACCCCACACCGTCAGGGCCG	0.642			NA											23	65					6.32553e-13	8.07164e-13	0.099896	1	0
SCRT1	83482	broad.mit.edu	37	8	145557006	145557006	+	Silent	SNP	C	C	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:145557006C>T	uc003zbw.1	-	2	1000	c.888G>A	c.(886-888)CAG>CAA	p.Q296Q		NM_031309	NP_112599	Q9BWW7	SCRT1_HUMAN	scratch	296	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.35e-39)|all cancers(56;1.37e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCGAATGCGTCTGCATGTGCG	0.627			NA											9	16					0	0	0.058154	0	0
NFKBIL2	4796	broad.mit.edu	37	8	145659566	145659566	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr8:145659566G>A	uc011llg.1	-	21	3197	c.3182C>T	c.(3181-3183)CCC>CTC	p.P1061L	uc011llh.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1061					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCGCAGCAGGGGTGTAAGCTG	0.697			NA											8	12					0	0	0.058154	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740869	37740869	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr9:37740869G>T	uc004aag.1	+	15	2388	c.2344G>T	c.(2344-2346)GGC>TGC	p.G782C	FRMPD1_uc004aah.1_Missense_Mutation_p.G782C|FRMPD1_uc011lqm.1_Missense_Mutation_p.G604C|FRMPD1_uc011lqn.1_Missense_Mutation_p.G651C	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	782						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CACTCCCCCAGGCCCCCCGTC	0.632			NA											18	14					3.51602e-12	4.32876e-12	0.049695	1	0
KLF4	9314	broad.mit.edu	37	9	110248154	110248154	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr9:110248154A>C	uc004bdh.2	-	4	2014	c.1393T>G	c.(1393-1395)TCA>GCA	p.S465A	KLF4_uc004bdf.1_Missense_Mutation_p.S390A|KLF4_uc004bdg.2_Missense_Mutation_p.S440A	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	474	Interaction with target DNA (By similarity).|C2H2-type 2.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						AGTTCATCTGAGCGGGCGAAT	0.498			NA											17	86					0	0	0.038395	0	0
ASTN2	23245	broad.mit.edu	37	9	119188208	119188208	+	Silent	SNP	G	G	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr9:119188208G>T	uc004bjs.1	-	23	4043	c.3942C>A	c.(3940-3942)CTC>CTA	p.L1314L	ASTN2_uc004bjr.1_Silent_p.L1310L|ASTN2_uc004bjt.1_Silent_p.L1263L|ASTN2_uc004bjp.1_Silent_p.L407L|ASTN2_uc004bjq.1_Silent_p.L366L|ASTN2_uc011lxr.1_Silent_p.L366L|ASTN2_uc011lxs.1_Silent_p.L366L|ASTN2_uc011lxt.1_Silent_p.L366L|ASTN2_uc004bjo.1_Silent_p.L95L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1314	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TGGTGTCCTTGAGGATGCTAT	0.587			NA											17	37					3.52763e-06	3.98281e-06	0.0333	1	0
OR1N1	138883	broad.mit.edu	37	9	125288754	125288754	+	Silent	SNP	A	A	T			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr9:125288754A>T	uc004bmn.1	-	1	819	c.819T>A	c.(817-819)GCT>GCA	p.A273A		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						TGTACATTGCAGCTGCTGCAA	0.507			NA											24	59					0	0	0.069288	0	0
FAM129B	64855	broad.mit.edu	37	9	130285969	130285969	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr9:130285969T>C	uc004brh.2	-	5	780	c.578A>G	c.(577-579)CAC>CGC	p.H193R	FAM129B_uc004bri.2_Missense_Mutation_p.H180R|FAM129B_uc004brj.3_Missense_Mutation_p.H193R	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	193							protein binding				0						ATTGTTGCAGTGCCGGATGCA	0.577			NA									OREG0019507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	44					0	0	0.069234	0	0
DOLK	22845	broad.mit.edu	37	9	131708329	131708329	+	Silent	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr9:131708329G>A	uc004bwr.2	-	1	1684	c.1254C>T	c.(1252-1254)CCC>CCT	p.P418P	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	418	Helical; (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						TCAGCCAGATGGGAAGAGACA	0.582			NA											17	62					0	0	0.0333	0	0
XG	7499	broad.mit.edu	37	X	2729460	2729460	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:2729460C>G	uc011mhg.1	+	9	716	c.493C>G	c.(493-495)CTA>GTA	p.L165V	XG_uc004cqp.2_Missense_Mutation_p.L180V	NM_175569	NP_780778	P55808	XG_HUMAN	XG glycoprotein isoform 1 precursor	165	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTATTTCAAACTAAACAATAG	0.403			NA											7	5					0	0	0.038147	0	0
FAM47C	442444	broad.mit.edu	37	X	37027350	37027350	+	Silent	SNP	T	T	C			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:37027350T>C	uc004ddl.1	+	1	881	c.867T>C	c.(865-867)ACT>ACC	p.T289T		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	289										ovary(3)	3						CTCCCAAGACTCGCGTATCTC	0.607			NA											4	71					0	0	0.009096	0	0
DGKK	139189	broad.mit.edu	37	X	50113550	50113550	+	Splice_Site	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:50113550T>A	uc010njr.1	-	28	3673	c.3613_splice	c.e28-1	p.E1205_splice		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					AGATTTTTCCTGAGAAACCAC	0.403			NA											5	3					0	0	0.014758	0	0
PABPC5	140886	broad.mit.edu	37	X	90691565	90691565	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:90691565G>A	uc004efg.2	+	2	1429	c.989G>A	c.(988-990)CGG>CAG	p.R330Q	PABPC5_uc004eff.1_Missense_Mutation_p.R166Q	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	330	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TCAATTAGTCGGGCCAAAGTG	0.458			NA											42	19					0	0	0.042209	0	0
COL4A5	1287	broad.mit.edu	37	X	107846235	107846235	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:107846235C>A	uc004enz.1	+	28	2390	c.2188C>A	c.(2188-2190)CCT>ACT	p.P730T	COL4A5_uc011mso.1_Missense_Mutation_p.P730T|COL4A5_uc004eob.1_Missense_Mutation_p.P338T	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	730	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						ACCTGGGACACCTGGAAGAAT	0.443			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				4	2					1.23904e-05	1.37984e-05	0.014758	1	0
COL4A5	1287	broad.mit.edu	37	X	107930878	107930878	+	Silent	SNP	T	T	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:107930878T>A	uc004enz.1	+	48	4684	c.4482T>A	c.(4480-4482)TCT>TCA	p.S1494S	COL4A5_uc011mso.1_Silent_p.S1491S|COL4A5_uc011msp.1_Silent_p.S170S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1488	Collagen IV NC1.		S -> F (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AAGGCTTTTCTCTCCTGTATG	0.433			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				30	102					0	0	0.050027	0	0
ATP1B4	23439	broad.mit.edu	37	X	119500506	119500506	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:119500506G>A	uc004esr.2	+	2	274	c.190G>A	c.(190-192)GAA>AAA	p.E64K	ATP1B4_uc004esq.2_Missense_Mutation_p.E64K|ATP1B4_uc011mtx.1_Missense_Mutation_p.E64K|ATP1B4_uc011mty.1_Missense_Mutation_p.E64K	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	64	Glu-rich.|Nuclear (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						agaagaggaggaagaggagga	0.353			NA											34	6					0	0	0.050027	0	0
FLNA	2316	broad.mit.edu	37	X	153593558	153593558	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chrX:153593558A>G	uc004fkk.2	-	11	1886	c.1637T>C	c.(1636-1638)GTC>GCC	p.V546A	FLNA_uc010nuu.1_Missense_Mutation_p.V546A	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	546	Filamin 3.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGTTCCAGGGACCATGGGGTA	0.622			NA											69	23					0	0	0.048971	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237139	33237139	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr1:33237139delT	uc001bvv.2	+	6	2318	c.2182delT	c.(2182-2184)TTCfs	p.F728fs	KIAA1522_uc001bvu.1_Frame_Shift_Del_p.F787fs|KIAA1522_uc010ohm.1_Frame_Shift_Del_p.F739fs|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	728	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CATGGCTGACTTCCCCCCACC	0.652			NA											30	76	---	---	---	---	NA	NA	NA	NA	NA
C14orf39	317761	broad.mit.edu	37	14	60935256	60935257	+	Splice_Site	INS	-	-	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr14:60935256_60935257insA	uc001xez.3	-	9	786	c.676_splice	c.e9-1	p.Q226_splice	C14orf39_uc010apo.2_Intron	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761											ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		AGATATCTGCTAAAAAGACAAT	0.282			NA											31	26	---	---	---	---	NA	NA	NA	NA	NA
RAI1	10743	broad.mit.edu	37	17	17696953	17696954	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr17:17696953_17696954insA	uc002grm.2	+	3	1160_1161	c.691_692insA	c.(691-693)CAGfs	p.Q231fs	RAI1_uc002grn.1_Frame_Shift_Ins_p.Q231fs	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	231	Gln-rich.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GGGTGGTGGGCAGGGGGCCCAC	0.668			NA											20	72	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29490318	29490321	+	Frame_Shift_Del	DEL	CGGA	CGGA	-			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	CGGA	CGGA	-	-	CGGA	CGGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr17:29490318_29490321delCGGA	uc002hgg.2	+	4	736_739	c.403_406delCGGA	c.(403-408)CGGAATfs	p.R135fs	NF1_uc002hge.1_Frame_Shift_Del_p.R135fs|NF1_uc002hgf.1_Frame_Shift_Del_p.R135fs|NF1_uc002hgh.2_Frame_Shift_Del_p.R135fs|NF1_uc010csn.1_Frame_Shift_Del_p.F30fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	135_136					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(5)|p.?(4)|p.L134fs*19(1)|p.R135fs*30(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGCTGAACTTCGGAATTCTGCCTC	0.436			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			19	28	---	---	---	---	NA	NA	NA	NA	NA
PRLR	5618	broad.mit.edu	37	5	35066004	35066004	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7535-01A-11D-2063-08	TCGA-78-7535-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fa8844f8-c4b6-487a-8187-e30c12a7a453	fc832d25-7dca-4b87-8df0-0fe45ca2c0fe	g.chr5:35066004delC	uc003jjm.2	-	10	1586	c.1056delG	c.(1054-1056)GGGfs	p.G352fs	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Frame_Shift_Del_p.G251fs	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	352	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGTCACAGCTCCCCCGGCCTG	0.498			NA											35	52	---	---	---	---	NA	NA	NA	NA	NA
