Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf158	93190	broad.mit.edu	37	1	12820814	12820814	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:12820814G>T	uc001auh.2	+	4	731	c.515G>T	c.(514-516)TGC>TTC	p.C172F		NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	172										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCGTTGTGCGCTATGTCC	0.577			NA											31	76					3.99451e-17	5.76087e-17	0.009535	1	0
LOC440563	440563	broad.mit.edu	37	1	13183396	13183396	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:13183396G>A	uc010obg.1	-	1	572	c.477C>T	c.(475-477)GGC>GGT	p.G159G		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	159						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TAGAATTGAAGCCACTTTTGC	0.512			NA											60	730					0	0	0.00361	0	0
PADI3	51702	broad.mit.edu	37	1	17597416	17597416	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:17597416C>A	uc001bai.2	+	8	914	c.874C>A	c.(874-876)CGA>AGA	p.R292R		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	292					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGTGGTGTTCCGAGTGGCACC	0.507			NA											17	54					1.67942e-08	2.00966e-08	0.006122	1	0
KLHDC7A	127707	broad.mit.edu	37	1	18809713	18809713	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:18809713G>A	uc001bax.2	+	1	2290	c.2238G>A	c.(2236-2238)GTG>GTA	p.V746V	KLHDC7A_uc009vpg.2_Intron	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	746						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGTTTGTGCCCAAGGAGC	0.647			NA											40	93					0	0	0.00623	0	0
FAM46B	115572	broad.mit.edu	37	1	27333018	27333018	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:27333018C>A	uc010ofj.1	-	2	867	c.695G>T	c.(694-696)TGC>TTC	p.C232F		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	232										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		AGTGGACGAGCACTGGCCAAA	0.582			NA											17	37					0.000566183	0.000606278	0.00499	1	0
C1orf94	84970	broad.mit.edu	37	1	34684349	34684349	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:34684349G>T	uc001bxs.3	+	7	1613	c.1214G>T	c.(1213-1215)GGC>GTC	p.G405V	C1orf94_uc001bxt.2_Missense_Mutation_p.G595V	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	405							protein binding				0		Myeloproliferative disorder(586;0.0393)				AGTGGGAATGGCATAAACTTT	0.507			NA											23	41					7.88262e-20	1.18835e-19	0.00333	1	0
DLGAP3	58512	broad.mit.edu	37	1	35370615	35370615	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:35370615G>T	uc001byc.2	-	1	370	c.370C>A	c.(370-372)CAG>AAG	p.Q124K		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	124					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				TTTTCAAACTGATCCAGGAGT	0.642			NA											9	13					2.17888e-05	2.44328e-05	0.006214	1	0
MACF1	23499	broad.mit.edu	37	1	39910339	39910339	+	Silent	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:39910339C>G	uc010oiu.1	+	45	14897	c.14766C>G	c.(14764-14766)CTC>CTG	p.L4922L	MACF1_uc010ois.1_Silent_p.L4420L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTAGGAACTCTATTCCCAGC	0.448			NA											24	48					0	0	0.00278	0	0
LRRC41	10489	broad.mit.edu	37	1	46745195	46745195	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:46745195C>T	uc001cpn.2	-	8	2156	c.2112G>A	c.(2110-2112)CTG>CTA	p.L704L	LRRC41_uc010omb.1_Silent_p.L704L	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	704	LRR 6.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GGAGGCCCTTCAGTGTGGAGT	0.572			NA											18	184					0	0	0.007413	0	0
USP24	23358	broad.mit.edu	37	1	55622646	55622646	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:55622646T>A	uc001cyg.3	-	11	1085	c.1085A>T	c.(1084-1086)GAA>GTA	p.E362V		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	474					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						TTTAGTGAGTTCATCTAACGA	0.373			NA											44	82					0	0	0.002522	0	0
LRRC8D	55144	broad.mit.edu	37	1	90400577	90400577	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:90400577C>T	uc001dnm.2	+	3	2375	c.1950C>T	c.(1948-1950)ATC>ATT	p.I650I	LRRC8D_uc001dnn.2_Silent_p.I650I	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	650	LRR 6.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		TAGAGAGAATCCCACATGCTA	0.393			NA											21	70					0	0	0.010504	0	0
COL11A1	1301	broad.mit.edu	37	1	103463870	103463870	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:103463870G>A	uc001dul.2	-	25	2510	c.2192C>T	c.(2191-2193)CCT>CTT	p.P731L	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P743L|COL11A1_uc001dun.2_Missense_Mutation_p.P692L|COL11A1_uc009weh.2_Missense_Mutation_p.P615L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	731	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACTTACAGGAGGCCCATCAGC	0.294			NA											6	10					0	0	0.006214	0	0
AKNAD1	254268	broad.mit.edu	37	1	109369848	109369848	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:109369848G>T	uc001dwa.2	-	11	2184	c.1915C>A	c.(1915-1917)CCA>ACA	p.P639T	AKNAD1_uc010ovb.1_Missense_Mutation_p.P346T|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	639										ovary(3)	3						TCTGAGTGTGGTGCCTTTTCA	0.483			NA											79	65					3.73172e-31	6.10533e-31	0.00361	1	0
HSD3B1	3283	broad.mit.edu	37	1	120054195	120054195	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:120054195C>A	uc001ehv.1	+	3	360	c.215C>A	c.(214-216)GCC>GAC	p.A72D	HSD3B1_uc001ehw.2_Missense_Mutation_p.A74D	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	72					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	CTGAAGAGAGCCTGCCAGGAC	0.488			NA											27	56					1.26454e-06	1.47431e-06	0.005443	1	0
PHGDH	26227	broad.mit.edu	37	1	120285605	120285605	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:120285605A>G	uc001ehz.2	+	11	1612	c.1385A>G	c.(1384-1386)GAC>GGC	p.D462G	PHGDH_uc009whm.2_Missense_Mutation_p.D360G|PHGDH_uc001eia.2_Missense_Mutation_p.D461G|PHGDH_uc009whn.2_Intron|PHGDH_uc001eib.2_Missense_Mutation_p.D428G|PHGDH_uc001eic.2_RNA	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	462					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	CTCCGCAGGGACCTGCCCCTG	0.622			NA											26	93					0	0	0.004656	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058123	152058123	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:152058123C>A	uc001ezo.1	-	3	2100	c.2035G>T	c.(2035-2037)GAC>TAC	p.D679Y		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	679							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCAGTGAAGTCTTCATCCAGG	0.483			NA											39	118					7.04047e-22	1.08432e-21	0.005524	1	0
FLG	2312	broad.mit.edu	37	1	152280365	152280365	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:152280365G>T	uc001ezu.1	-	3	7033	c.6997C>A	c.(6997-6999)CAC>AAC	p.H2333N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2333	Ser-rich.|Filaggrin 14.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTGGTGGTGGGATCCGTGT	0.552			NA							Ichthyosis				140	503					6.47883e-55	1.11481e-54	0.00361	1	0
FLG2	388698	broad.mit.edu	37	1	152326424	152326424	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:152326424C>T	uc001ezw.3	-	3	3911	c.3838G>A	c.(3838-3840)GTG>ATG	p.V1280M	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1280	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTGAGTGCACTTCACTGTCA	0.478			NA											61	182					0	0	0.00361	0	0
CADM3	57863	broad.mit.edu	37	1	159161822	159161822	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:159161822G>C	uc001ftl.2	+	2	327	c.185G>C	c.(184-186)TGG>TCG	p.W62S	CADM3_uc009wsx.1_Missense_Mutation_p.W96S|CADM3_uc009wsy.1_Missense_Mutation_p.W62S|CADM3_uc001ftk.2_Missense_Mutation_p.W96S	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	62	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TCCCTGCAATGGTCTAACCCT	0.522			NA											8	39					0	0	0.00308	0	0
OR10J1	26476	broad.mit.edu	37	1	159409813	159409813	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:159409813C>A	uc010piv.1	+	1	265	c.265C>A	c.(265-267)CTC>ATC	p.L89I	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	89	Extracellular (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					ATTGGTCATTCTCCCAAGAAT	0.458			NA											14	66					9.31168e-06	1.06085e-05	0.001855	1	0
ATP1A2	477	broad.mit.edu	37	1	160105660	160105660	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:160105660C>A	uc001fvc.2	+	17	2448	c.2316C>A	c.(2314-2316)TCC>TCA	p.S772S	ATP1A2_uc001fvb.2_Silent_p.S772S|ATP1A2_uc001fvd.2_Silent_p.S508S	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	772	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGAAGAAATCCATCGCCTACA	0.567			NA											26	104					1.04121e-07	1.2312e-07	0.005443	1	0
DCAF8	50717	broad.mit.edu	37	1	160187467	160187467	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:160187467T>C	uc001fvo.2	-	14	2021	c.1709A>G	c.(1708-1710)GAC>GGC	p.D570G	DCAF8_uc001fvn.2_Missense_Mutation_p.D570G|DCAF8_uc009wth.2_Missense_Mutation_p.D570G|DCAF8_uc010pjb.1_Missense_Mutation_p.D570G|DCAF8_uc010pjc.1_Missense_Mutation_p.D724G	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	570						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						AGAGTCCGCGTCTGTGGCCCC	0.587			NA											9	53					0	0	0.000978	0	0
LY9	4063	broad.mit.edu	37	1	160783461	160783461	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:160783461G>T	uc001fwu.2	+	3	540	c.490G>T	c.(490-492)GTG>TTG	p.V164L	LY9_uc010pjs.1_Missense_Mutation_p.V164L|LY9_uc001fwv.2_Missense_Mutation_p.V164L|LY9_uc001fww.2_Missense_Mutation_p.V164L|LY9_uc001fwx.2_Missense_Mutation_p.V164L|LY9_uc001fwy.1_Missense_Mutation_p.V66L|LY9_uc001fwz.2_5'Flank	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	164	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CATGAAGTCTGTGAAGGTGTC	0.532			NA											24	69					6.12954e-19	9.07608e-19	0.004656	1	0
FCGR2B	2213	broad.mit.edu	37	1	161645092	161645092	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:161645092C>A	uc001gaz.1	+	6	898	c.806C>A	c.(805-807)CCT>CAT	p.P269H	FCGR2B_uc001gay.1_Missense_Mutation_p.P268H|FCGR2B_uc001gba.1_Intron|FCGR2B_uc001gbb.1_Intron|FCGR2B_uc009wun.1_Missense_Mutation_p.P262H	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	269	Cytoplasmic (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GAGACCCTCCCTGAGAAACCA	0.597			NA	T	?	ALL								5	18					3.59834e-05	3.94631e-05	0.001168	1	0
TOR3A	64222	broad.mit.edu	37	1	179064300	179064300	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:179064300T>C	uc001gmd.2	+	6	1293	c.1141T>C	c.(1141-1143)TCT>CCT	p.S381P	TOR3A_uc010pnd.1_Missense_Mutation_p.S165P	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	381					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						ACAACTCTTTTCTTCCCAGGG	0.483			NA											80	138					0	0	0.00361	0	0
APOBEC4	403314	broad.mit.edu	37	1	183617857	183617857	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:183617857G>T	uc001gqn.2	-	2	332	c.60C>A	c.(58-60)TAC>TAA	p.Y20*	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron	NM_203454	NP_982279	Q8WW27	ABEC4_HUMAN	apolipoprotein B	20					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0						AGCTTAGCCAGTAATATGGTT	0.388			NA											16	49					2.31682e-05	2.58057e-05	0.003163	1	0
KCNT2	343450	broad.mit.edu	37	1	196274387	196274387	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:196274387G>T	uc001gtd.1	-	22	2632	c.2572C>A	c.(2572-2574)CTT>ATT	p.L858I	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.L784I|KCNT2_uc001gtf.1_Missense_Mutation_p.L834I|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.L834I|KCNT2_uc001gth.1_Missense_Mutation_p.L355I	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	858	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GAAAGAGCAAGAGAGTAACAG	0.338			NA											10	43					2.17888e-05	2.44328e-05	0.006214	1	0
KCNT2	343450	broad.mit.edu	37	1	196311222	196311222	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:196311222G>T	uc001gtd.1	-	15	1600	c.1540C>A	c.(1540-1542)CAT>AAT	p.H514N	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Missense_Mutation_p.H514N|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.H514N|KCNT2_uc001gth.1_Missense_Mutation_p.H35N	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	514	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTGTGTGCATGGAAAGAGGCA	0.333			NA											9	38					4.68919e-08	5.5845e-08	0.008291	1	0
KIF21B	23046	broad.mit.edu	37	1	200967643	200967643	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:200967643A>T	uc001gvs.1	-	14	2263	c.1946T>A	c.(1945-1947)CTG>CAG	p.L649Q	KIF21B_uc001gvr.1_Missense_Mutation_p.L649Q|KIF21B_uc009wzl.1_Missense_Mutation_p.L649Q|KIF21B_uc010ppn.1_Missense_Mutation_p.L649Q	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	649	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CTCGTCGATCAGCTTCTGCTT	0.562			NA											8	67					0	0	0.004482	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202462440	202462440	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:202462440G>C	uc001gya.1	+	15	2284	c.2140G>C	c.(2140-2142)GAA>CAA	p.E714Q	PPP1R12B_uc001gxz.1_Missense_Mutation_p.E714Q|PPP1R12B_uc001gyb.1_5'UTR|PPP1R12B_uc001gyc.1_5'UTR	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	714					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAGTCTGGATGAAGAGGTGAG	0.532			NA											5	19					0	0	0.000602	0	0
TMEM81	388730	broad.mit.edu	37	1	205053359	205053359	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:205053359G>A	uc001hbt.2	-	1	230	c.90C>T	c.(88-90)GCC>GCT	p.A30A		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	30						integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			TCTCAGGGATGGCCAGTGTTT	0.517			NA											13	60					0	0	0.00245	0	0
CENPF	1063	broad.mit.edu	37	1	214818013	214818013	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:214818013G>T	uc001hkm.2	+	13	5274	c.5100G>T	c.(5098-5100)CAG>CAT	p.Q1700H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1796					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ATGCTCAGCAGGACCTCAATC	0.423	Colon(80;575 1284 11000 14801 43496)		NA											17	53					1.45105e-14	2.02822e-14	0.006122	1	0
CENPF	1063	broad.mit.edu	37	1	214830292	214830292	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:214830292C>T	uc001hkm.2	+	18	8676	c.8502C>T	c.(8500-8502)ACC>ACT	p.T2834T		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2930	Potential.|Sufficient for nuclear localization.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TTATGGATACCAAGGTCGATG	0.388	Colon(80;575 1284 11000 14801 43496)		NA											12	50					0	0	0.000978	0	0
SPATA17	128153	broad.mit.edu	37	1	217955640	217955640	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:217955640G>T	uc001hlh.1	+	8	874	c.848G>T	c.(847-849)TGG>TTG	p.W283L	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.W283L	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	283						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AGAGAGGAATGGCTGCAAAAT	0.383			NA											14	37					1.3612e-06	1.58331e-06	0.003163	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232596659	232596659	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:232596659C>A	uc001hvg.2	-	8	3227	c.3069G>T	c.(3067-3069)CAG>CAT	p.Q1023H	SIPA1L2_uc001hvf.2_Missense_Mutation_p.Q97H	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1023	PDZ.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CATCATGGGGCTGGATGATGA	0.587			NA											14	23					2.32078e-09	2.85239e-09	0.003163	1	0
RYR2	6262	broad.mit.edu	37	1	237843796	237843796	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:237843796G>C	uc001hyl.1	+	62	9056	c.8936G>C	c.(8935-8937)CGT>CCT	p.R2979P	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2979	Modulator (Potential).|Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAAACCATCGTTTATACTTC	0.388			NA											2	6					0	0	0.004672	0	0
CHRM3	1131	broad.mit.edu	37	1	240071510	240071510	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:240071510G>T	uc001hyp.2	+	5	1538	c.759G>T	c.(757-759)AGG>AGT	p.R253S		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	253	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TATACTGGAGGATCTATAAGG	0.473			NA											11	59					3.07112e-06	3.53108e-06	0.000978	1	0
FMN2	56776	broad.mit.edu	37	1	240351543	240351543	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:240351543G>C	uc010pyd.1	+	4	2192	c.1967G>C	c.(1966-1968)CGC>CCC	p.R656P	FMN2_uc010pye.1_Missense_Mutation_p.R660P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	656					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCAAAAACGCTCAGATGCT	0.378			NA											18	58					0	0	0.010504	0	0
CEP170	9859	broad.mit.edu	37	1	243327830	243327830	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:243327830G>T	uc001hzs.2	-	13	3840	c.3432C>A	c.(3430-3432)ATC>ATA	p.I1144I	CEP170_uc001hzt.2_Silent_p.I1046I|CEP170_uc001hzu.2_Silent_p.I1046I|CEP170_uc001hzv.1_Silent_p.I522I	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1144	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CAATCCGAGAGATGTTACGCC	0.453			NA											5	30					0.00307968	0.00319493	0.00308	1	0
ZNF496	84838	broad.mit.edu	37	1	247492753	247492753	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:247492753C>A	uc001ico.2	-	3	593	c.128G>T	c.(127-129)CGT>CTT	p.R43L	ZNF496_uc009xgv.2_Missense_Mutation_p.R43L|ZNF496_uc001icp.2_Missense_Mutation_p.R43L|ZNF496_uc010pyv.1_Missense_Mutation_p.R43L	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	43	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GCGGAAGAGACGCCGAGAGGA	0.697			NA											20	41					5.03518e-11	6.47566e-11	0.007413	1	0
OR14A16	284532	broad.mit.edu	37	1	247978691	247978691	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:247978691G>T	uc001idm.1	-	1	341	c.341C>A	c.(340-342)ACG>AAG	p.T114K		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGACATCACCGTGAGGAGGAG	0.478	Ovarian(112;180 1586 15073 21914 33526)		NA											30	62					1.16021e-09	1.43303e-09	0.007291	1	0
OR2L13	284521	broad.mit.edu	37	1	248263154	248263154	+	Silent	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:248263154A>T	uc001ids.2	+	3	814	c.477A>T	c.(475-477)ACA>ACT	p.T159T		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGGCACACACAGTCTTTGCCC	0.483			NA											64	139					0	0	0.00361	0	0
OR2T12	127064	broad.mit.edu	37	1	248458061	248458061	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:248458061C>T	uc010pzj.1	-	1	820	c.820G>A	c.(820-822)GCC>ACC	p.A274T		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GTATAGAAGGCTGACACAACC	0.483			NA											10	142					0	0	0.006214	0	0
OR2T1	26696	broad.mit.edu	37	1	248570175	248570175	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:248570175C>G	uc010pzm.1	+	1	880	c.880C>G	c.(880-882)CAC>GAC	p.H294D		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	294	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCTCATCCCACATGACTGT	0.517			NA											14	67					0	0	0.00245	0	0
ANKRD16	54522	broad.mit.edu	37	10	5929972	5929972	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:5929972C>T	uc010qat.1	-	2	916	c.373G>A	c.(373-375)GAA>AAA	p.E125K	ANKRD16_uc009xie.2_Missense_Mutation_p.E125K|ANKRD16_uc009xif.2_Missense_Mutation_p.E125K|ANKRD16_uc001iiq.2_Missense_Mutation_p.E125K|FBXO18_uc001iir.2_5'Flank|FBXO18_uc001iis.2_5'Flank|FBXO18_uc009xig.2_5'Flank	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	125	ANK 3.										0						GCGCCATGTTCCACCAGCTCC	0.557			NA											43	106					0	0	0.00361	0	0
FBXO18	84893	broad.mit.edu	37	10	5948307	5948307	+	Silent	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:5948307A>T	uc001iis.2	+	3	560	c.465A>T	c.(463-465)CCA>CCT	p.P155P	FBXO18_uc001iir.2_Silent_p.P81P|FBXO18_uc009xig.2_Silent_p.P81P|FBXO18_uc001iit.2_Silent_p.P206P	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	155	F-box.				DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TGTCTGTGCCATGCACAAGGC	0.587			NA											27	31					0	0	0.004656	0	0
NMT2	9397	broad.mit.edu	37	10	15151838	15151838	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:15151838T>A	uc001inz.1	-	11	1423	c.1339A>T	c.(1339-1341)AAA>TAA	p.K447*	NMT2_uc001ioa.1_Nonsense_Mutation_p.K434*|NMT2_uc009xjo.1_Intron|NMT2_uc010qbz.1_Nonsense_Mutation_p.K259*	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	447					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						TCAAATCCTTTCTGCCAATTT	0.299	Melanoma(117;1345 1645 4130 12688 30625)		NA											7	41					0	0	0.00308	0	0
CACNB2	783	broad.mit.edu	37	10	18827284	18827284	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:18827284C>A	uc001ipr.2	+	13	1538	c.1478C>A	c.(1477-1479)TCT>TAT	p.S493Y	CACNB2_uc009xjz.1_Missense_Mutation_p.S243Y|CACNB2_uc001ips.2_Missense_Mutation_p.S469Y|CACNB2_uc001ipt.2_Missense_Mutation_p.S455Y|CACNB2_uc001ipu.2_Missense_Mutation_p.S465Y|CACNB2_uc001ipv.2_Missense_Mutation_p.S441Y|CACNB2_uc009xka.1_Missense_Mutation_p.S427Y|CACNB2_uc001ipw.2_Missense_Mutation_p.S400Y|CACNB2_uc001ipx.2_Missense_Mutation_p.S438Y|CACNB2_uc001ipz.2_Missense_Mutation_p.S415Y|CACNB2_uc001ipy.2_Missense_Mutation_p.S439Y|CACNB2_uc010qco.1_Missense_Mutation_p.S407Y|CACNB2_uc001iqa.2_Missense_Mutation_p.S445Y|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	493					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACCCTAGCCTCTAATTCACAG	0.473			NA											58	167					2.93687e-30	4.77361e-30	0.00361	1	0
CACNB2	783	broad.mit.edu	37	10	18827288	18827288	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:18827288T>A	uc001ipr.2	+	13	1542	c.1482T>A	c.(1480-1482)AAT>AAA	p.N494K	CACNB2_uc009xjz.1_Missense_Mutation_p.N244K|CACNB2_uc001ips.2_Missense_Mutation_p.N470K|CACNB2_uc001ipt.2_Missense_Mutation_p.N456K|CACNB2_uc001ipu.2_Missense_Mutation_p.N466K|CACNB2_uc001ipv.2_Missense_Mutation_p.N442K|CACNB2_uc009xka.1_Missense_Mutation_p.N428K|CACNB2_uc001ipw.2_Missense_Mutation_p.N401K|CACNB2_uc001ipx.2_Missense_Mutation_p.N439K|CACNB2_uc001ipz.2_Missense_Mutation_p.N416K|CACNB2_uc001ipy.2_Missense_Mutation_p.N440K|CACNB2_uc010qco.1_Missense_Mutation_p.N408K|CACNB2_uc001iqa.2_Missense_Mutation_p.N446K|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	494					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TAGCCTCTAATTCACAGGTAA	0.483			NA											54	160					0	0	0.00361	0	0
MYO3A	53904	broad.mit.edu	37	10	26463005	26463005	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:26463005T>C	uc001isn.2	+	30	4172	c.3812T>C	c.(3811-3813)GTG>GCG	p.V1271A	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1271					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGCTACCCAGTGCCTTGGTTA	0.398			NA											30	55					0	0	0.008361	0	0
MYO3A	53904	broad.mit.edu	37	10	26463048	26463048	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:26463048G>T	uc001isn.2	+	30	4215	c.3855G>T	c.(3853-3855)TTG>TTT	p.L1285F	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1285					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AAAAAACTTTGGAACCTACAC	0.413			NA											20	78					3.8784e-16	5.4825e-16	0.001882	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37508664	37508664	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:37508664A>T	uc001iza.1	+	34	3955	c.3856A>T	c.(3856-3858)AAG>TAG	p.K1286*		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1342						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TCATGCACATAAGAAAGCTGA	0.328			NA											10	31					0	0	0.006214	0	0
ANUBL1	93550	broad.mit.edu	37	10	46121515	46121515	+	Missense_Mutation	SNP	G	G	A	rs35142284	byFrequency	TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:46121515G>A	uc001jcp.3	-	7	1998	c.1756C>T	c.(1756-1758)CGT>TGT	p.R586C	ANUBL1_uc001jcl.3_Missense_Mutation_p.R106C|ANUBL1_uc001jcm.3_Missense_Mutation_p.R586C|ANUBL1_uc009xmu.2_Missense_Mutation_p.R512C|ANUBL1_uc001jcn.3_Missense_Mutation_p.R512C|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	586							zinc ion binding				0						CCTGCCCCACGTGTGCTCTGT	0.463			NA											41	59					0	0	0.002522	0	0
PRKG1	5592	broad.mit.edu	37	10	53564429	53564429	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:53564429A>G	uc001jjm.2	+	4	826	c.632A>G	c.(631-633)GAG>GGG	p.E211G	PRKG1_uc001jjn.2_Missense_Mutation_p.E226G|PRKG1_uc001jjo.2_Missense_Mutation_p.E226G	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	211	cGMP 1.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		AAGCATACCGAGTATATGGAA	0.353			NA											6	30					0	0	0.00308	0	0
PCDH15	65217	broad.mit.edu	37	10	55849811	55849811	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:55849811C>T	uc001jju.1	-	16	2325	c.1930G>A	c.(1930-1932)GAG>AAG	p.E644K	PCDH15_uc010qhq.1_Missense_Mutation_p.E649K|PCDH15_uc010qhr.1_Missense_Mutation_p.E644K|PCDH15_uc010qhs.1_Missense_Mutation_p.E656K|PCDH15_uc010qht.1_Missense_Mutation_p.E651K|PCDH15_uc010qhu.1_Missense_Mutation_p.E644K|PCDH15_uc001jjv.1_Missense_Mutation_p.E622K|PCDH15_uc010qhv.1_Missense_Mutation_p.E644K|PCDH15_uc010qhw.1_Missense_Mutation_p.E607K|PCDH15_uc010qhx.1_Intron|PCDH15_uc010qhy.1_Missense_Mutation_p.E649K|PCDH15_uc010qhz.1_Missense_Mutation_p.E644K|PCDH15_uc010qia.1_Missense_Mutation_p.E622K|PCDH15_uc010qib.1_Missense_Mutation_p.E622K|PCDH15_uc001jjw.2_Missense_Mutation_p.E644K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	644	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GAGTCTCCCTCTCGATCAGTT	0.328			NA								HNSCC(58;0.16)			16	36					0	0	0.00499	0	0
COL13A1	1305	broad.mit.edu	37	10	71562455	71562455	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:71562455C>T	uc001jpr.1	+	1	812	c.276C>T	c.(274-276)GTC>GTT	p.V92V	COL13A1_uc001jqj.1_Silent_p.V92V|COL13A1_uc001jps.1_Silent_p.V92V|COL13A1_uc001jpt.1_Silent_p.V92V|COL13A1_uc001jpu.1_Silent_p.V92V|COL13A1_uc001jpv.1_Silent_p.V92V|COL13A1_uc001jpx.1_Silent_p.V92V|COL13A1_uc001jpw.1_Silent_p.V92V|COL13A1_uc001jpy.1_Silent_p.V92V|COL13A1_uc001jpz.1_Silent_p.V92V|COL13A1_uc001jqa.1_Silent_p.V92V|COL13A1_uc001jqc.1_Silent_p.V92V|COL13A1_uc001jqb.1_Silent_p.V92V|COL13A1_uc001jql.2_Silent_p.V92V|COL13A1_uc001jqd.1_Silent_p.V92V|COL13A1_uc001jqe.1_Silent_p.V92V|COL13A1_uc001jqf.1_Silent_p.V92V|COL13A1_uc001jqg.1_Silent_p.V92V|COL13A1_uc001jqh.1_Silent_p.V92V|COL13A1_uc001jqi.1_Silent_p.V92V	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	92	Extracellular (Potential).|Nonhelical region 1 (NC1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	TGGGACGAGTCAATCAACTGC	0.652			NA											53	124					0	0	0.00361	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72495043	72495043	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:72495043C>G	uc001jrh.2	+	9	1471	c.1471C>G	c.(1471-1473)CAG>GAG	p.Q491E	ADAMTS14_uc001jrg.2_Missense_Mutation_p.Q494E|ADAMTS14_uc001jri.1_Missense_Mutation_p.Q14E	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	491	Disintegrin.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						CAGTGGCTACCAGACCTGCTT	0.597			NA											22	25					0	0	0.004656	0	0
C10orf58	84293	broad.mit.edu	37	10	82180396	82180396	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:82180396A>G	uc001kcc.3	+	2	333	c.173A>G	c.(172-174)GAG>GGG	p.E58G	C10orf58_uc001kcd.3_Missense_Mutation_p.E47G|C10orf58_uc001kce.3_Missense_Mutation_p.E58G|C10orf58_uc001kcf.3_Missense_Mutation_p.E58G	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	58						extracellular region					0			Colorectal(32;0.229)			AAAACACTGGAGAAGGGTAAG	0.483			NA											4	42					0	0	0.009096	0	0
GRID1	2894	broad.mit.edu	37	10	87482766	87482766	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:87482766G>T	uc001kdl.1	-	12	2092	c.1991C>A	c.(1990-1992)CCC>CAC	p.P664H	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.P235H	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	664	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTACCTTATGGGGTTGTCCAT	0.532			NA								Multiple Myeloma(13;0.14)			7	11					1.12685e-05	1.27505e-05	0.004482	1	0
C10orf28	27291	broad.mit.edu	37	10	99995212	99995212	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:99995212T>C	uc001kow.3	+	7	2358	c.2063T>C	c.(2062-2064)ATG>ACG	p.M688T	C10orf28_uc001kox.3_Missense_Mutation_p.M702T|C10orf28_uc001koy.3_Missense_Mutation_p.M688T|C10orf28_uc009xvx.2_Missense_Mutation_p.M688T|C10orf28_uc009xvy.2_Missense_Mutation_p.M94T|C10orf28_uc001koz.3_RNA	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	688							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		AAACACACCATGGTGAAGATT	0.448			NA											16	13					0	0	0.004007	0	0
HPSE2	60495	broad.mit.edu	37	10	100995443	100995443	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:100995443G>A	uc001kpn.1	-	1	177	c.117C>T	c.(115-117)TCC>TCT	p.S39S	HPSE2_uc009xwc.1_Silent_p.S29S|HPSE2_uc001kpo.1_Silent_p.S29S|HPSE2_uc009xwd.1_Silent_p.S29S	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	39					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		CTCCAGCCTGGGAGGAAAGGG	0.592			NA											48	63					0	0	0.002852	0	0
NEURL	9148	broad.mit.edu	37	10	105331285	105331285	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:105331285G>A	uc001kxh.2	+	3	765	c.355G>A	c.(355-357)GGG>AGG	p.G119R		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	119	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CTGCTGGAGCGGGGCCCTGCG	0.672			NA											4	27					0	0	0.009096	0	0
SORCS1	114815	broad.mit.edu	37	10	108923969	108923969	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:108923969C>A	uc001kym.2	-	1	324	c.316G>T	c.(316-318)GGC>TGC	p.G106C	SORCS1_uc001kyl.2_Missense_Mutation_p.G106C|SORCS1_uc009xxs.2_Missense_Mutation_p.G106C|SORCS1_uc001kyn.1_Missense_Mutation_p.G106C|SORCS1_uc001kyo.2_Missense_Mutation_p.G106C	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	106	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTCCTCCGGCCGGAGCGTGCA	0.701			NA											6	26					2.0095e-06	2.32116e-06	0.001984	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118383471	118383471	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:118383471A>C	uc001lcq.2	+	5	91	c.68A>C	c.(67-69)TAC>TCC	p.Y23S	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	22					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		AGAGTCTGCTACGGACAACTT	0.498			NA											3	48					0	0	0.004672	0	0
FAM45A	404636	broad.mit.edu	37	10	120882985	120882985	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:120882985C>T	uc001ldw.2	+	6	642	c.598C>T	c.(598-600)CTG>TTG	p.L200L	FAM45A_uc010qsv.1_Silent_p.L192L|FAM45A_uc010qsw.1_Silent_p.L49L|FAM45A_uc010qsx.1_RNA|FAM45A_uc010qsy.1_Silent_p.L127L|FAM45A_uc010qsz.1_Silent_p.L89L	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	200										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		CCCCAGGACTCTGCCTGCCCT	0.418			NA											10	16					0	0	0.006214	0	0
CPXM2	119587	broad.mit.edu	37	10	125526576	125526576	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:125526576C>A	uc001lhk.1	-	10	1717	c.1392G>T	c.(1390-1392)TGG>TGT	p.W464C	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	464					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CCTCTGCCTCCCAGAGCAGCG	0.517			NA											25	27					1.55469e-16	2.2229e-16	0.00333	1	0
EBF3	253738	broad.mit.edu	37	10	131639270	131639270	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr10:131639270C>G	uc001lki.1	-	14	1431	c.1372G>C	c.(1372-1374)GTG>CTG	p.V458L		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	467	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CGCGGGGACACGCTGCTTGTA	0.552			NA											21	38					0	0	0.001882	0	0
MUC6	4588	broad.mit.edu	37	11	1028697	1028698	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:1028697_1028698TG>AT	uc001lsw.2	-	13	1590_1591	c.1539_1540CA>AT	c.(1537-1542)CCCATC>CCATTC	p.I514F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	514	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCTGGAAGATGGGGCGCAGCT	0.629			NA											14	15					0	0	0.004672	0	0
OR52R1	119695	broad.mit.edu	37	11	4825094	4825094	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:4825094G>T	uc010qym.1	-	1	754	c.754C>A	c.(754-756)CAA>AAA	p.Q252K		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTTGGTGTTGGCAGAAGGGC	0.552			NA											9	91					0.00829132	0.00856598	0.008291	1	0
OR52E2	119678	broad.mit.edu	37	11	5080090	5080090	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:5080090G>T	uc010qyw.1	-	1	768	c.768C>A	c.(766-768)GCC>GCA	p.A256A		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGGAAAAGAGGGCTGGTGTAT	0.473			NA											31	41					2.61193e-14	3.62043e-14	0.009535	1	0
OR52E6	390078	broad.mit.edu	37	11	5862504	5862504	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:5862504C>T	uc010qzq.1	-	1	624	c.624G>A	c.(622-624)TTG>TTA	p.L208L	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATCCAATAACAAGAGAGAAA	0.478			NA											11	34					0	0	0.008291	0	0
NLRP14	338323	broad.mit.edu	37	11	7060055	7060056	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:7060055_7060056GG>TT	uc001mfb.1	+	2	561_562	c.238_239GG>TT	c.(238-240)GGC>TTC	p.G80F		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	80	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CAAAATCTTTGGCAAGATGAAC	0.485			NA											15	26					0	0	0.004672	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16848004	16848004	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:16848004C>T	uc001mmo.2	-	10	1021	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	PLEKHA7_uc010rcu.1_Missense_Mutation_p.E336K|PLEKHA7_uc001mmn.2_Missense_Mutation_p.E44K	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	336					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TCCTGCCTCTCGAAGTTGACA	0.617			NA											39	58					0	0	0.006999	0	0
USH1C	10083	broad.mit.edu	37	11	17519757	17519757	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:17519757G>T	uc001mnf.2	-	19	1651	c.1542C>A	c.(1540-1542)ACC>ACA	p.T514T	USH1C_uc001mne.2_Silent_p.T814T|USH1C_uc009yhb.2_Silent_p.T495T|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Silent_p.T478T	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	514	PDZ 3.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CCTCAGCCAGGGTGTAGTCTG	0.577			NA											21	121					9.57634e-11	1.21593e-10	0.00333	1	0
PTPN5	84867	broad.mit.edu	37	11	18759452	18759452	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:18759452C>G	uc001mpd.2	-	9	1406	c.975G>C	c.(973-975)AAG>AAC	p.K325N	PTPN5_uc001mpb.2_Missense_Mutation_p.K293N|PTPN5_uc001mpc.2_Missense_Mutation_p.K325N|PTPN5_uc001mpe.2_Missense_Mutation_p.K293N|PTPN5_uc010rdj.1_Missense_Mutation_p.K269N|PTPN5_uc001mpf.2_Missense_Mutation_p.K301N|PTPN5_uc010rdk.1_Missense_Mutation_p.K270N	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	325	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						TGTACCGGTTCTTCCGCACCA	0.582			NA											11	48					0	0	0.000978	0	0
NAV2	89797	broad.mit.edu	37	11	20066601	20066601	+	Missense_Mutation	SNP	G	G	A	rs146962426		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:20066601G>A	uc010rdm.1	+	15	3717	c.3356G>A	c.(3355-3357)CGG>CAG	p.R1119Q	NAV2_uc001mpp.2_Missense_Mutation_p.R1032Q|NAV2_uc001mpr.3_Missense_Mutation_p.R1096Q|NAV2_uc001mpt.2_Missense_Mutation_p.R182Q|NAV2_uc009yhx.2_Missense_Mutation_p.R182Q|NAV2_uc009yhy.1_Missense_Mutation_p.R95Q	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1119						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GATGCAGGCCGGAGCAGTGGT	0.542			NA											9	67					0	0	0.001368	0	0
NELL1	4745	broad.mit.edu	37	11	21392425	21392425	+	Missense_Mutation	SNP	G	G	C	rs8176788	byFrequency	TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:21392425G>C	uc001mqe.2	+	15	1729	c.1576G>C	c.(1576-1578)GGT>CGT	p.G526R	NELL1_uc001mqf.2_Missense_Mutation_p.G526R|NELL1_uc009yid.2_Missense_Mutation_p.G554R|NELL1_uc010rdo.1_Missense_Mutation_p.G469R|NELL1_uc010rdp.1_Missense_Mutation_p.G286R|NELL1_uc001mqg.2_RNA|NELL1_uc001mqh.2_Silent_p.T135T	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	526	EGF-like 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CTGCAGATACGGTGGAACGTG	0.438			NA											3	26					0	0	0.009096	0	0
BBOX1	8424	broad.mit.edu	37	11	27141304	27141304	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:27141304C>A	uc001mre.1	+	7	1116	c.748C>A	c.(748-750)CAG>AAG	p.Q250K	BBOX1_uc009yih.1_Missense_Mutation_p.Q250K|BBOX1_uc001mrg.1_Missense_Mutation_p.Q250K	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	250					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	TCAGGCATTCCAGATTTTGTC	0.348			NA											20	20					2.21704e-12	2.92672e-12	0.00278	1	0
ELP4	26610	broad.mit.edu	37	11	31531535	31531535	+	Silent	SNP	A	A	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:31531535A>C	uc001mtb.2	+	1	239	c.204A>C	c.(202-204)CCA>CCC	p.P68P	IMMP1L_uc001msy.1_5'Flank|IMMP1L_uc001msz.1_5'Flank|ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.P68P|ELP4_uc010rdz.1_Silent_p.P68P|IMMP1L_uc009yjo.2_5'Flank|IMMP1L_uc009yjp.2_5'Flank	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	68					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CCGGGCTCCCAGCCCTAGACC	0.642			NA											21	36					0	0	0.010504	0	0
OR5L2	26338	broad.mit.edu	37	11	55595459	55595459	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:55595459C>A	uc001nhy.1	+	1	765	c.765C>A	c.(763-765)ATC>ATA	p.I255I		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				ATGGAACAATCCTTTACATTT	0.507			NA								HNSCC(27;0.073)			48	51					2.76378e-25	4.36433e-25	0.00361	1	0
OR8H2	390151	broad.mit.edu	37	11	55872770	55872770	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:55872770G>A	uc010riy.1	+	1	252	c.252G>A	c.(250-252)GCG>GCA	p.A84A		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					AAACCTTAGCGAACTTACTGA	0.438			NA								HNSCC(53;0.14)			17	396					0	0	0.006122	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995427	57995427	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:57995427C>T	uc010rkd.1	-	1	921	c.921G>A	c.(919-921)AGG>AGA	p.R307R		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				TAATGGCACTCCTCAGAGCAC	0.502			NA											24	172					0	0	0.002299	0	0
CPSF7	79869	broad.mit.edu	37	11	61178472	61178472	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:61178472T>A	uc001nrq.2	-	9	1493	c.1359A>T	c.(1357-1359)CAA>CAT	p.Q453H	CPSF7_uc001nro.2_Missense_Mutation_p.Q444H|CPSF7_uc001nrp.2_Missense_Mutation_p.Q496H|CPSF7_uc001nrr.2_Missense_Mutation_p.Q444H	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	453	Arg-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GGTTCCTTTCTTGGAAATAAT	0.577			NA											14	210					0	0	0.00499	0	0
AHNAK	79026	broad.mit.edu	37	11	62293335	62293335	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:62293335C>A	uc001ntl.2	-	5	8854	c.8554G>T	c.(8554-8556)GAT>TAT	p.D2852Y	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2852					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACATCCACATCTCCTTTTATT	0.423			NA											68	176					1.20466e-24	1.88441e-24	0.00361	1	0
AHNAK	79026	broad.mit.edu	37	11	62300119	62300119	+	Silent	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:62300119T>A	uc001ntl.2	-	5	2070	c.1770A>T	c.(1768-1770)ACA>ACT	p.T590T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	590					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTCTGGGGAGTGTGACATCTA	0.512			NA											27	73					0	0	0.003954	0	0
LGALS12	85329	broad.mit.edu	37	11	63279290	63279290	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:63279290C>A	uc001nxa.2	+	7	1032	c.691C>A	c.(691-693)CTG>ATG	p.L231M	LGALS12_uc001nxb.2_Missense_Mutation_p.L222M|LGALS12_uc001nxc.2_Missense_Mutation_p.L232M|LGALS12_uc001nxd.2_Missense_Mutation_p.L170M|LGALS12_uc001nxe.2_Missense_Mutation_p.L161M|LGALS12_uc009yot.2_Missense_Mutation_p.L191M	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform	231	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						AGTACGGGGACTGGTCTTGCA	0.423			NA											26	73					3.1745e-13	4.26974e-13	0.008361	1	0
GRM5	2915	broad.mit.edu	37	11	88300349	88300349	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:88300349G>T	uc001pcq.2	-	7	2702	c.2502C>A	c.(2500-2502)CGC>CGA	p.R834R	GRM5_uc009yvm.2_Silent_p.R834R	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	834	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TGAAGGCGCTGCGCACGTTTC	0.572			NA											22	69					4.35082e-09	5.30821e-09	0.010504	1	0
TYR	7299	broad.mit.edu	37	11	89028428	89028428	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:89028428T>A	uc001pcs.2	+	5	1566	c.1484T>A	c.(1483-1485)CTT>CAT	p.L495H		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	495	Helical; (Potential).			L -> P (in Ref. 2; AAA61241/AAA61244).	eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CTGGCAGGGCTTGTGAGCTTG	0.537			NA							Oculocutaneous_Albinism				14	33					0	0	0.004007	0	0
PGR	5241	broad.mit.edu	37	11	100933417	100933417	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:100933417T>C	uc001pgh.2	-	4	2716	c.1973A>G	c.(1972-1974)CAG>CGG	p.Q658R	PGR_uc001pgg.2_Missense_Mutation_p.Q39R|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	658					cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	GCCCACTGGCTGTGGGAGAGC	0.408	Pancreas(124;2271 2354 21954 22882)		NA											16	118					0	0	0.003163	0	0
MMP8	4317	broad.mit.edu	37	11	102585338	102585338	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:102585338G>A	uc001phe.2	-	8	1238	c.1139C>T	c.(1138-1140)GCT>GTT	p.A380V	MMP8_uc010rut.1_Intron|MMP8_uc010ruu.1_Missense_Mutation_p.A357V	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	380	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		GTAGAAAACAGCTGCGTCAAT	0.383			NA											21	41					0	0	0.001882	0	0
DIXDC1	85458	broad.mit.edu	37	11	111844948	111844948	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:111844948C>A	uc001pml.2	+	4	815	c.518C>A	c.(517-519)TCA>TAA	p.S173*	DIXDC1_uc001pmj.2_Nonsense_Mutation_p.S166*|DIXDC1_uc001pmk.2_Nonsense_Mutation_p.S173*	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	173	Actin-binding.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		ATGTCCCGATCAGGACGGGAT	0.532			NA											5	17					0.000602214	0.000642105	0.000602	1	0
FAM55B	120406	broad.mit.edu	37	11	114569400	114569400	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:114569400G>A	uc009yyy.2	+	3	864	c.766G>A	c.(766-768)GTG>ATG	p.V256M		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	256						integral to membrane				ovary(1)	1						CTTCTACTGTGTGAGGCCTCA	0.473			NA											19	35					0	0	0.006122	0	0
PVRL1	5818	broad.mit.edu	37	11	119510581	119510581	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:119510581C>A	uc001pwu.1	-	6	1317	c.1145G>T	c.(1144-1146)GGG>GTG	p.G382V		NM_203285	NP_976030	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 2	Error:Variant_position_missing_in_Q15223_after_alignment					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		TCACCCGGCCCCATCCGTCTC	0.607			NA											43	37					1.30916e-28	2.10733e-28	0.00361	1	0
UBASH3B	84959	broad.mit.edu	37	11	122650373	122650373	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:122650373G>T	uc001pyi.3	+	4	931	c.571G>T	c.(571-573)GAC>TAC	p.D191Y		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	191						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		GTTTGCTGCTGACTTTGCTGC	0.547			NA											12	37					1.05317e-09	1.30405e-09	0.00245	1	0
HSPA8	3312	broad.mit.edu	37	11	122931888	122931888	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:122931888G>A	uc001pyo.2	-	2	223	c.145C>T	c.(145-147)CGG>TGG	p.R49W	HSPA8_uc009zbc.2_5'Flank|HSPA8_uc001pyp.2_Missense_Mutation_p.R49W|HSPA8_uc010rzu.1_Missense_Mutation_p.R49W|HSPA8_uc009zbd.1_Missense_Mutation_p.R49W|HSPA8_uc010rzv.1_Missense_Mutation_p.R49W	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	49					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCGATCAACCGTTCAGTGTCC	0.443	Colon(21;486 594 5900 6733 14272)		NA											20	21					0	0	0.008871	0	0
OR8G2	26492	broad.mit.edu	37	11	124095815	124095815	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr11:124095815T>G	uc010saf.1	+	1	418	c.418T>G	c.(418-420)TGC>GGC	p.C140G		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	140						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGTTGCCATCTGCAGCCCCTT	0.458			NA											45	81					0	0	0.009718	0	0
NANOG	79923	broad.mit.edu	37	12	7942359	7942359	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:7942359C>A	uc009zfy.1	+	1	365	c.149C>A	c.(148-150)ACT>AAT	p.T50N		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	50					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		CACACGGAGACTGGTAAGAAA	0.438			NA											56	48					7.91745e-34	1.31694e-33	0.00361	1	0
OR8S1	341568	broad.mit.edu	37	12	48921852	48921852	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:48921852C>A	uc010slu.1	+	2	1046	c.1046C>A	c.(1045-1047)TCC>TAC	p.S349Y		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	349	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGCGCATGCTCCGCGCTGCGC	0.657			NA											13	11					1.5842e-08	1.90486e-08	0.001855	1	0
ACVRL1	94	broad.mit.edu	37	12	52314573	52314573	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:52314573G>T	uc001rzj.2	+	10	1691	c.1408G>T	c.(1408-1410)GAG>TAG	p.E470*	ACVRL1_uc001rzk.2_Nonsense_Mutation_p.E470*|ACVRL1_uc010snm.1_Nonsense_Mutation_p.E296*	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	470	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GATGATGCGGGAGTGCTGGTA	0.418			NA							Hereditary_Hemorrhagic_Telangiectasia				15	21					8.28177e-16	1.16411e-15	0.007413	1	0
PTPRB	5787	broad.mit.edu	37	12	71029663	71029663	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:71029663C>A	uc001swc.3	-	2	283	c.239G>T	c.(238-240)CGC>CTC	p.R80L	PTPRB_uc001swa.3_Missense_Mutation_p.R80L|PTPRB_uc001swd.3_Missense_Mutation_p.R79L|PTPRB_uc009zrr.1_Intron|PTPRB_uc001swe.2_Missense_Mutation_p.R80L	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GATGGCTGAGCGGGAGGGGCC	0.542			NA											11	8					3.07112e-06	3.53108e-06	0.000978	1	0
CHPT1	56994	broad.mit.edu	37	12	102110587	102110587	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:102110587T>A	uc001tin.2	+	4	868	c.645T>A	c.(643-645)TAT>TAA	p.Y215*	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Nonsense_Mutation_p.Y215*	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	215					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						TGTGGGACTATACGGTAAATC	0.308			NA											3	20					0	0	0.009096	0	0
MED13L	23389	broad.mit.edu	37	12	116399155	116399155	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:116399155C>A	uc001tvw.2	-	31	6604	c.6549G>T	c.(6547-6549)CCG>CCT	p.P2183P		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	2183					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCTGGGTGGCCGGATTGCACG	0.517			NA											18	24					2.35188e-11	3.04828e-11	0.006122	1	0
KSR2	283455	broad.mit.edu	37	12	117964883	117964883	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:117964883G>A	uc001two.2	-	13	1812	c.1757C>T	c.(1756-1758)ACG>ATG	p.T586M		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	615					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CACCTCCGACGTTGGCTCCAC	0.463			NA											70	86					0	0	0.00361	0	0
NCOR2	9612	broad.mit.edu	37	12	124817787	124817787	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr12:124817787C>A	uc010tay.1	-	44	6830	c.6674G>T	c.(6673-6675)GGT>GTT	p.G2225V	NCOR2_uc010taz.1_Missense_Mutation_p.G2209V|NCOR2_uc010tax.1_Missense_Mutation_p.G336V	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2226					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		ACCGTCCTCACCACCACCCAA	0.632			NA											15	10					5.01169e-05	5.46034e-05	0.00499	1	0
FLT3	2322	broad.mit.edu	37	13	28589732	28589732	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr13:28589732G>T	uc001urw.2	-	21	2730	c.2648C>A	c.(2647-2649)TCA>TAA	p.S883*	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Nonsense_Mutation_p.S842*	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	883	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTTACCAAGTGAGAAGATTTC	0.532			NA	Mis|O		AML|ALL								27	23					1.17739e-12	1.56672e-12	0.005443	1	0
FLT3	2322	broad.mit.edu	37	13	28608088	28608088	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr13:28608088G>A	uc001urw.2	-	15	1960	c.1878C>T	c.(1876-1878)AAC>AAT	p.N626N	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Silent_p.N626N	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	626	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.N626_A627ins31(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	AAGCTGTTGCGTTCATCACTT	0.413			NA	Mis|O		AML|ALL								74	80					0	0	0.00361	0	0
KIAA0564	23078	broad.mit.edu	37	13	42263624	42263624	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr13:42263624G>A	uc001uyj.2	-	34	4067	c.3997C>T	c.(3997-3999)CAT>TAT	p.H1333Y		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1333						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GAAATTTTATGAGGTATGCTG	0.348			NA											24	26					0	0	0.004656	0	0
TM9SF1	10548	broad.mit.edu	37	14	24680654	24680654	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:24680654G>A	uc010tob.1	-	3	1038	c.404C>T	c.(403-405)GCT>GTT	p.A135V	CHMP4A_uc001wni.2_Missense_Mutation_p.A152V|CHMP4A_uc010toc.1_RNA|CHMP4A_uc001wnj.2_Missense_Mutation_p.A152V	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	Error:Variant_position_missing_in_O15321_after_alignment					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		GCTTTGGGCAGCAAGCTCCAT	0.552			NA											5	23					0	0	0.001168	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885569	24885569	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:24885569G>A	uc001wpf.3	+	9	4932	c.4614G>A	c.(4612-4614)ACG>ACA	p.T1538T		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1538					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TAGTCCCGACGCAACTCCGGA	0.547			NA											4	15					0	0	0.009096	0	0
AKAP6	9472	broad.mit.edu	37	14	33291952	33291952	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:33291952C>T	uc001wrq.2	+	13	5103	c.4933C>T	c.(4933-4935)CCC>TCC	p.P1645S		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1645	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TATCCAGAGCCCCTCAGAGCA	0.433	Melanoma(49;821 1200 7288 13647 42351)		NA											8	45					0	0	0.004482	0	0
INSM2	84684	broad.mit.edu	37	14	36005115	36005115	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:36005115C>A	uc001wth.1	+	1	1868	c.1657C>A	c.(1657-1659)CGG>AGG	p.R553R		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		CTCAGAAAGCCGGCAAGTGCT	0.562			NA											32	40					2.68265e-12	3.53204e-12	0.002836	1	0
MLH3	27030	broad.mit.edu	37	14	75497253	75497253	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:75497253A>G	uc001xrd.1	-	9	4196	c.3980T>C	c.(3979-3981)ATT>ACT	p.I1327T	MLH3_uc001xre.1_Missense_Mutation_p.I1303T|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	1327					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TACCTCCACAATACTCTTGGT	0.378			NA						MMR					5	143					0	0	0.000602	0	0
KCNK13	56659	broad.mit.edu	37	14	90651091	90651091	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:90651091A>T	uc001xye.1	+	2	1413	c.971A>T	c.(970-972)AAC>ATC	p.N324I		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	324	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				AACCGCTGCAACATCTCCATA	0.607			NA											52	48					0	0	0.00361	0	0
BCL11B	64919	broad.mit.edu	37	14	99641437	99641437	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:99641437G>T	uc001yga.2	-	4	2003	c.1736C>A	c.(1735-1737)GCG>GAG	p.A579E	BCL11B_uc001ygb.2_Missense_Mutation_p.A508E	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	579	Gly-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		gccgccccccgcgcccgggac	0.557			NA	T	TLX3	T-ALL								5	8					0.00198382	0.00207531	0.001984	1	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709637	22709637	+	Missense_Mutation	SNP	T	T	G	rs140467724	by1000genomes	TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:22709637T>G	uc010axw.2	-	10	1148	c.250A>C	c.(250-252)AAC>CAC	p.N84H	GOLGA8DP_uc010axx.2_Missense_Mutation_p.N84H|uc010tzw.1_5'Flank	NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E												0						CCCATCTGGTTTTTGAGTTTG	0.547			NA											4	58					0	0	0.009096	0	0
C15orf2	23742	broad.mit.edu	37	15	24921416	24921416	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:24921416G>T	uc001ywo.2	+	1	876	c.402G>T	c.(400-402)GCG>GCT	p.A134A		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	134					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTGAGCCGGCGGTCAAGGCCA	0.632			NA											12	29					0.00185496	0.00195692	0.001855	1	0
GABRB3	2562	broad.mit.edu	37	15	26793113	26793113	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:26793113C>A	uc001zaz.2	-	9	1391	c.1249G>T	c.(1249-1251)GGG>TGG	p.G417W	GABRB3_uc010uae.1_Missense_Mutation_p.G332W|GABRB3_uc001zba.2_Missense_Mutation_p.G417W|GABRB3_uc001zbb.2_Missense_Mutation_p.G473W	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	417	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTTCTGTCCCCCAGGAATCGC	0.498			NA											25	39					9.57634e-11	1.21593e-10	0.00333	1	0
NDNL2	56160	broad.mit.edu	37	15	29561629	29561629	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:29561629T>A	uc001zco.2	-	1	389	c.281A>T	c.(280-282)CAG>CTG	p.Q94L	FAM189A1_uc010azk.1_Intron	NM_138704	NP_619649	Q96MG7	MAGG1_HUMAN	necdin-like 2	94	MAGE.				regulation of growth	cytoplasm|nucleus					0		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CAGCAAGAACTGCACCAGCTC	0.448			NA											41	36					0	0	0.002522	0	0
RYR3	6263	broad.mit.edu	37	15	33954852	33954852	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:33954852G>T	uc001zhi.2	+	35	5191	c.5121G>T	c.(5119-5121)GGG>GGT	p.G1707G	RYR3_uc010bar.2_Silent_p.G1707G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1707	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGTGCAGCGGGGCCCACATCC	0.567			NA											20	29					0.00188189	0.00198115	0.001882	1	0
ADAL	161823	broad.mit.edu	37	15	43641179	43641179	+	Silent	SNP	C	C	T	rs112836130		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:43641179C>T	uc010udo.1	+	10	1201	c.627C>T	c.(625-627)CTC>CTT	p.L209L	ADAL_uc001zrh.2_Silent_p.L236L|ADAL_uc001zri.1_Silent_p.L121L	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	236					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GAACATTTCTCAACTCCGGTG	0.478			NA											22	35					0	0	0.010504	0	0
RORA	6095	broad.mit.edu	37	15	60806923	60806923	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:60806923T>A	uc002agv.2	-	5	571	c.415A>T	c.(415-417)ACC>TCC	p.T139S	uc002ags.1_Intron|RORA_uc002agt.3_Missense_Mutation_p.T51S|RORA_uc002agw.2_Missense_Mutation_p.T131S|RORA_uc002agx.2_Missense_Mutation_p.T106S	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	139	Nuclear receptor.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CAGGAGTAGGTGGCATTGCTT	0.438			NA											29	32					0	0	0.00632	0	0
NTRK3	4916	broad.mit.edu	37	15	88678565	88678565	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:88678565A>G	uc002bme.1	-	9	1133	c.971T>C	c.(970-972)GTG>GCG	p.V324A	NTRK3_uc002bmh.2_Missense_Mutation_p.V324A|NTRK3_uc002bmf.1_Missense_Mutation_p.V324A|NTRK3_uc010upl.1_Missense_Mutation_p.V226A|NTRK3_uc010bnh.1_Missense_Mutation_p.V324A|NTRK3_uc002bmg.2_Missense_Mutation_p.V324A	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	324	Ig-like C2-type 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCCACGCACCACAAACTCGAT	0.597			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			22	22					0	0	0.001882	0	0
FANCI	55215	broad.mit.edu	37	15	89805064	89805064	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:89805064G>T	uc010bnp.1	+	6	548	c.458G>T	c.(457-459)GGG>GTG	p.G153V	FANCI_uc002bnm.1_Missense_Mutation_p.G153V|FANCI_uc002bnn.1_RNA|FANCI_uc002bno.2_Missense_Mutation_p.G153V|FANCI_uc002bnp.1_5'Flank	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	153					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GTACTGAGTGGGGAAGAATGT	0.353			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				32	38					3.69857e-22	5.73163e-22	0.008361	1	0
MAN2A2	4122	broad.mit.edu	37	15	91447494	91447494	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:91447494C>T	uc010bnz.2	+	2	172	c.57C>T	c.(55-57)GTC>GTT	p.V19V	MAN2A2_uc010boa.2_Silent_p.V61V|MAN2A2_uc002bqc.2_Silent_p.V19V|MAN2A2_uc010uql.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	19	Helical; Signal-anchor for type II membrane protein; (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTGTGGCAGTCTTCTCGCTCT	0.562			NA											45	39					0	0	0.00361	0	0
TTC23	64927	broad.mit.edu	37	15	99678309	99678309	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr15:99678309G>A	uc002bur.2	-	13	1781	c.1250C>T	c.(1249-1251)CCA>CTA	p.P417L	TTC23_uc002bus.2_Missense_Mutation_p.P417L|TTC23_uc002but.2_Missense_Mutation_p.P417L|TTC23_uc002buu.2_Missense_Mutation_p.P417L|TTC23_uc002buv.2_Missense_Mutation_p.P417L|TTC23_uc002bux.2_Missense_Mutation_p.P417L|TTC23_uc002buw.2_Missense_Mutation_p.P417L|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Missense_Mutation_p.P417L|TTC23_uc010bor.2_Missense_Mutation_p.P417L	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	417							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			TGCCTGCCTTGGCTTCGAAGC	0.652			NA											17	19					0	0	0.006122	0	0
SEC14L5	9717	broad.mit.edu	37	16	5053500	5053500	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:5053500G>T	uc002cye.2	+	11	1408	c.1228G>T	c.(1228-1230)GAC>TAC	p.D410Y		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	410	CRAL-TRIO.					integral to membrane|intracellular	transporter activity				0						GGTGGTTGAGGACAATTACCC	0.647			NA											16	37					1.02788e-11	1.3392e-11	0.00499	1	0
MKL2	57496	broad.mit.edu	37	16	14311020	14311020	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:14311020G>C	uc010uza.1	+	7	545	c.390G>C	c.(388-390)ATG>ATC	p.M130I	MKL2_uc002dcg.2_Missense_Mutation_p.M130I|MKL2_uc002dch.2_Missense_Mutation_p.M119I|MKL2_uc010uzb.1_Missense_Mutation_p.M79I	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	119					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						CTACTCAGATGAAGTTGAAAA	0.393			NA											8	87					0	0	0.00308	0	0
GPR139	124274	broad.mit.edu	37	16	20043068	20043068	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:20043068C>T	uc002dgu.1	-	2	1213	c.1051G>A	c.(1051-1053)GTA>ATA	p.V351I	GPR139_uc010vaw.1_Missense_Mutation_p.V258I	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	351	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CACGGGGATACTTTTATAGGT	0.463			NA											21	88					0	0	0.008871	0	0
UMOD	7369	broad.mit.edu	37	16	20355495	20355495	+	Splice_Site	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:20355495C>T	uc002dgz.2	-	6	1312	c.1183_splice	c.e6-1	p.R395_splice	UMOD_uc002dha.2_Splice_Site_p.R395_splice|UMOD_uc002dhb.2_Splice_Site_p.R428_splice	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor						cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						TTTCATTCCTCTGTTGCAGGG	0.507			NA											8	39					0	0	0.004482	0	0
DNAH3	55567	broad.mit.edu	37	16	21086872	21086873	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:21086872_21086873TG>AT	uc010vbe.1	-	21	2979_2980	c.2979_2980CA>AT	c.(2977-2982)CCCATT>CCATTT	p.I994F		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	994	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCTGCACCAATGGGCTCCAATC	0.406			NA											3	59					0	0	0.004672	0	0
TNRC6A	27327	broad.mit.edu	37	16	24826516	24826516	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:24826516A>T	uc002dmm.2	+	19	4835	c.4721A>T	c.(4720-4722)TAT>TTT	p.Y1574F	TNRC6A_uc010bxs.2_Missense_Mutation_p.Y1321F|TNRC6A_uc002dmn.2_Missense_Mutation_p.Y1272F|TNRC6A_uc002dmo.2_Missense_Mutation_p.Y1213F|TNRC6A_uc002dmp.2_Missense_Mutation_p.Y175F|TNRC6A_uc002dmq.2_Missense_Mutation_p.Y241F	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1574					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TTTGTTCCCTATGACTTTATG	0.438			NA											24	55					0	0	0.003954	0	0
MVP	9961	broad.mit.edu	37	16	29845347	29845347	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:29845347C>T	uc002dui.2	+	5	621	c.537C>T	c.(535-537)CGC>CGT	p.R179R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010bzh.1_RNA|MVP_uc010vdz.1_Intron|MVP_uc002duj.2_Silent_p.R179R|MVP_uc010vea.1_5'UTR	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	179	MVP 4.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TCAGGGCCCGCAAGGAGTGCT	0.657			NA											12	53					0	0	0.000978	0	0
RNF40	9810	broad.mit.edu	37	16	30780669	30780669	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:30780669C>T	uc002dzq.2	+	16	2533	c.2410C>T	c.(2410-2412)CGG>TGG	p.R804W	RNF40_uc010caa.2_Missense_Mutation_p.R804W|RNF40_uc010cab.2_Missense_Mutation_p.R704W|RNF40_uc010vfa.1_Missense_Mutation_p.R136W|RNF40_uc002dzr.2_Missense_Mutation_p.R804W|RNF40_uc010vfb.1_Missense_Mutation_p.R496W|RNF40_uc010vfc.1_Missense_Mutation_p.R136W	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	804	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CAAGCTGCTGCGGGAGGAGAA	0.582			NA											44	74					0	0	0.00361	0	0
ZNF646	9726	broad.mit.edu	37	16	31089217	31089217	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:31089217C>T	uc002eap.2	+	2	1861	c.1572C>T	c.(1570-1572)ATC>ATT	p.I524I		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						GTGCAGACATCGGGGCTGAGG	0.622			NA											20	31					0	0	0.010504	0	0
SALL1	6299	broad.mit.edu	37	16	51174189	51174189	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:51174189G>A	uc010vgs.1	-	2	1975	c.1944C>T	c.(1942-1944)GAC>GAT	p.D648D	SALL1_uc010vgr.1_Silent_p.D551D|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	648					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CGGGGCCGCAGTCTGCCGCTG	0.622	GBM(103;1352 1446 1855 4775 8890)		NA											25	72					0	0	0.00333	0	0
IRX6	79190	broad.mit.edu	37	16	55360368	55360368	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:55360368C>T	uc002ehy.2	+	2	699	c.166C>T	c.(166-168)CTG>TTG	p.L56L	IRX6_uc002ehx.2_Silent_p.L56L|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	56						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CGATAGTCGACTGCTGGGCAG	0.657			NA											18	26					0	0	0.006122	0	0
PRMT7	54496	broad.mit.edu	37	16	68373273	68373273	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:68373273G>T	uc002evy.1	+	8	829	c.553G>T	c.(553-555)GTG>TTG	p.V185L	PRMT7_uc002evx.1_Missense_Mutation_p.V185L|PRMT7_uc010vlg.1_Missense_Mutation_p.V135L|PRMT7_uc002evz.1_Missense_Mutation_p.V31L	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	185					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		TGCACAGCTGGTGGAGTCCGG	0.517			NA											27	50					7.41945e-09	8.96442e-09	0.005443	1	0
PKD1L2	114780	broad.mit.edu	37	16	81155284	81155284	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:81155284G>A	uc002fgh.1	-	40	6519	c.6519C>T	c.(6517-6519)CTC>CTT	p.L2173L	PKD1L2_uc002fgf.1_5'UTR|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2173	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGTACAGGCGGAGGCTCTGCA	0.602			NA											3	17					0	0	0.009096	0	0
MBTPS1	8720	broad.mit.edu	37	16	84126810	84126810	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:84126810C>A	uc002fhi.2	-	6	1331	c.829G>T	c.(829-831)GTC>TTC	p.V277F		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	277	Serine protease.|Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TTGGTAAAGACCCTGAAAATG	0.463			NA											24	51					3.5997e-14	4.97576e-14	0.002299	1	0
CDH15	1013	broad.mit.edu	37	16	89261522	89261522	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:89261522C>G	uc002fmt.2	+	14	2481	c.2404C>G	c.(2404-2406)CCT>GCT	p.P802A		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	802	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGGTCTTTCTCCTGGGGCACT	0.692			NA											15	21					0	0	0.00499	0	0
C16orf7	9605	broad.mit.edu	37	16	89774285	89774285	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr16:89774285C>T	uc002fom.1	-	15	2005	c.1880G>A	c.(1879-1881)GGA>GAA	p.G627E	C16orf7_uc002fol.1_Missense_Mutation_p.G557E	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	627	VPS9.				ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGCCAGGCCTCCCCGGGGCAG	0.647			NA											18	67					0	0	0.006122	0	0
PITPNM3	83394	broad.mit.edu	37	17	6386998	6386998	+	Silent	SNP	C	C	A	rs145663997	byFrequency	TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:6386998C>A	uc002gdd.3	-	6	577	c.426G>T	c.(424-426)ACG>ACT	p.T142T	PITPNM3_uc010cln.2_Silent_p.T106T|PITPNM3_uc002gdc.3_5'Flank	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	142					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		CCCCGGCACCCGTGTCCAGGA	0.632			NA											35	38					1.60099e-16	2.28255e-16	0.004878	1	0
NLGN2	57555	broad.mit.edu	37	17	7319398	7319398	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:7319398A>G	uc002ggt.1	+	6	1679	c.1606A>G	c.(1606-1608)ACC>GCC	p.T536A		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	536	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				CGTGGTCATGACCTACTGGAC	0.502			NA											3	53					0	0	0.004672	0	0
SLFN11	91607	broad.mit.edu	37	17	33679476	33679476	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:33679476G>T	uc010ctp.2	-	7	3047	c.2605C>A	c.(2605-2607)CAT>AAT	p.H869N	SLFN11_uc010ctq.2_Missense_Mutation_p.H869N|SLFN11_uc002hjh.3_Missense_Mutation_p.H869N|SLFN11_uc002hjg.3_Missense_Mutation_p.H869N|SLFN11_uc010ctr.2_Missense_Mutation_p.H869N	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	869						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTCCTTGGATGGATCCCAAAC	0.493			NA											90	86					1.90436e-54	3.26554e-54	0.00361	1	0
KRT40	125115	broad.mit.edu	37	17	39140304	39140304	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:39140304C>A	uc010cxh.1	-	3	383	c.222G>T	c.(220-222)GTG>GTT	p.V74V	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	74	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				CACAGTTCCCCACCAAGCAGG	0.547			NA											107	78					6.17951e-33	1.01768e-32	0.00361	1	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394532	39394532	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:39394532C>T	uc002hwh.3	+	1	263	c.229C>T	c.(229-231)CAG>TAG	p.Q77*	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	77	10.|15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			ACCCTGCTGTCAGCCCACCTG	0.617			NA											32	114					0	0	0.002836	0	0
CRHR1	1394	broad.mit.edu	37	17	43893861	43893862	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:43893861_43893862GG>TT	uc010dap.2	+	3	419_420	c.154_155GG>TT	c.(154-156)GGC>TTC	p.G52F	CRHR1_uc010wjx.1_5'UTR|CRHR1_uc002ijp.2_5'UTR|CRHR1_uc002ijm.2_Missense_Mutation_p.G52F|CRHR1_uc002ijn.2_Intron|CRHR1_uc010dar.2_Missense_Mutation_p.G52F|CRHR1_uc010dao.2_5'UTR|CRHR1_uc010daq.2_5'UTR|CRHR1_uc010das.1_RNA|CRHR1_uc002ijo.1_Intron	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	52	Extracellular (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		GGACCTCATTGGCACCTGCTGG	0.614	Ovarian(110;57 1568 10207 38216 49865)		NA											14	38					0	0	0.004672	0	0
ITGB3	3690	broad.mit.edu	37	17	45376782	45376782	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:45376782T>A	uc002ilj.2	+	11	1819	c.1799T>A	c.(1798-1800)CTG>CAG	p.L600Q	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	600	IV.|Extracellular (Potential).|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	AATGGGCTGCTGTGCAGCGGC	0.617			NA											38	88					0	0	0.00623	0	0
ACSF2	80221	broad.mit.edu	37	17	48551068	48551068	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:48551068G>A	uc002iqu.2	+	13	1622	c.1518G>A	c.(1516-1518)GTG>GTA	p.V506V	ACSF2_uc010wml.1_Silent_p.V463V|ACSF2_uc010wmm.1_Silent_p.V531V|ACSF2_uc010wmn.1_Silent_p.V493V|ACSF2_uc010wmo.1_Silent_p.V346V|ACSF2_uc010dbt.1_Silent_p.V10V	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	506					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GCAAGATCGTGGGCCGCTCTA	0.547			NA											71	43					0	0	0.00361	0	0
SPAG9	9043	broad.mit.edu	37	17	49197912	49197912	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:49197912C>T	uc002itc.2	-	1	315	c.106G>A	c.(106-108)GAG>AAG	p.E36K	SPAG9_uc002itb.2_Missense_Mutation_p.E36K|SPAG9_uc002itd.2_Missense_Mutation_p.E36K	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	36					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			ATAAGCCGCTCGAACTCGCGG	0.667			NA											12	21					0	0	0.001855	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386681	56386681	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:56386681C>A	uc002ivx.3	-	22	4823	c.3952G>T	c.(3952-3954)GAG>TAG	p.E1318*	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Nonsense_Mutation_p.E1258*|BZRAP1_uc010wnt.1_Nonsense_Mutation_p.E1318*	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1318						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGGGCAGCTCCAGGATCTGC	0.463			NA											20	56					1.87028e-06	2.1704e-06	0.001882	1	0
BRIP1	83990	broad.mit.edu	37	17	59876591	59876591	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:59876591C>T	uc002izk.1	-	9	1351	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	404	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CTTGCTGATTCCCGAGCACAG	0.358			NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				35	52					0	0	0.003755	0	0
BPTF	2186	broad.mit.edu	37	17	65850718	65850718	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:65850718G>A	uc002jgf.2	+	2	1337	c.1276G>A	c.(1276-1278)GAG>AAG	p.E426K	BPTF_uc002jge.2_Missense_Mutation_p.E426K|BPTF_uc010wqm.1_Missense_Mutation_p.E426K	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	426	PHD-type 1.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GGAGGTGCCAGAGGACGAGTG	0.453			NA											15	156					0	0	0.00245	0	0
ABCA5	23461	broad.mit.edu	37	17	67251713	67251713	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:67251713C>A	uc002jif.2	-	30	5257	c.4039G>T	c.(4039-4041)GTT>TTT	p.V1347F	ABCA5_uc002jib.2_Missense_Mutation_p.V313F|ABCA5_uc002jic.2_Missense_Mutation_p.V570F|ABCA5_uc002jid.2_Missense_Mutation_p.V264F|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.V1347F	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1347	ABC transporter 2.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					ATATCACCAACCAGAATATTA	0.308			NA											13	25					0.000308642	0.00033264	0.003163	1	0
SDK2	54549	broad.mit.edu	37	17	71354288	71354288	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:71354288G>A	uc010dfm.2	-	40	5523	c.5523C>T	c.(5521-5523)GCC>GCT	p.A1841A	SDK2_uc002jjt.3_Silent_p.A981A|SDK2_uc010dfn.2_Silent_p.A1520A	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1841	Fibronectin type-III 13.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						ACCAGTGAATGGCGATGGCAG	0.657			NA											24	229					0	0	0.00333	0	0
BAHCC1	57597	broad.mit.edu	37	17	79411726	79411726	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:79411726C>G	uc002kaf.2	+	6	2545	c.2545C>G	c.(2545-2547)CCC>GCC	p.P849A	BAHCC1_uc002kae.2_Missense_Mutation_p.P48A	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	849	Pro-rich.						DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CCAGAACCTGCCCCCCGGCTT	0.706			NA											21	61					0	0	0.00278	0	0
LPIN2	9663	broad.mit.edu	37	18	2937988	2937988	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:2937988A>C	uc002klo.2	-	7	1109	c.870T>G	c.(868-870)ATT>ATG	p.I290M		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	290					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTGATGGTGTAATTGTAGCTG	0.368			NA											10	152					0	0	0.006214	0	0
LAMA1	284217	broad.mit.edu	37	18	6949140	6949140	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:6949140C>A	uc002knm.2	-	59	8610	c.8516G>T	c.(8515-8517)GGA>GTA	p.G2839V	LAMA1_uc002knk.2_Missense_Mutation_p.G169V|LAMA1_uc002knl.2_Missense_Mutation_p.G292V|LAMA1_uc010wzj.1_Missense_Mutation_p.G2315V	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2839	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGCAGGCCTCCTAGGTAGAA	0.473			NA											28	31					1.17739e-12	1.56672e-12	0.005443	1	0
TXNDC2	84203	broad.mit.edu	37	18	9887087	9887087	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:9887087C>T	uc002koi.3	+	2	1060	c.611C>T	c.(610-612)CCC>CTC	p.P204L	TXNDC2_uc010wzq.1_Intron|TXNDC2_uc002koh.3_Missense_Mutation_p.P137L	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	204	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|7.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GCCATCCAGCCCAAAGAGGGT	0.577			NA											89	215					0	0	0.00361	0	0
MPPE1	65258	broad.mit.edu	37	18	11886778	11886778	+	Splice_Site	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:11886778C>A	uc002kqf.2	-	8	1320	c.679_splice	c.e8-1	p.A227_splice	MPPE1_uc002kqn.2_Intron|MPPE1_uc002kqg.2_Splice_Site|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_Splice_Site|MPPE1_uc002kqj.2_Missense_Mutation_p.Q227H|MPPE1_uc002kqk.2_Intron|MPPE1_uc002kql.2_Missense_Mutation_p.Q227H|MPPE1_uc002kqm.2_Intron|MPPE1_uc010dla.1_Missense_Mutation_p.Q227H	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor						ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						AGCCACGTGCCTGCTGGGTAC	0.632			NA											25	36					4.4004e-07	5.15446e-07	0.00333	1	0
DSC2	1824	broad.mit.edu	37	18	28651738	28651738	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:28651738C>T	uc002kwl.3	-	13	2412	c.1958G>A	c.(1957-1959)AGA>AAA	p.R653K	DSC2_uc002kwk.3_Missense_Mutation_p.R653K	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	653	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AAGTCTATCTCTCACTGTTAT	0.388			NA											14	30					0	0	0.00245	0	0
DSC1	1823	broad.mit.edu	37	18	28720033	28720033	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:28720033G>A	uc002kwn.2	-	10	1754	c.1492C>T	c.(1492-1494)CCG>TCG	p.P498S	DSC1_uc002kwm.2_Missense_Mutation_p.P498S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	498	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GATATTTCCGGGTCCAGTGCT	0.408			NA											18	81					0	0	0.00499	0	0
KLHL14	57565	broad.mit.edu	37	18	30267189	30267189	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:30267189G>T	uc002kxm.1	-	5	1555	c.1167C>A	c.(1165-1167)CAC>CAA	p.H389Q	KLHL14_uc010dmd.1_5'UTR	NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	389	Kelch 2.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						AATTTGTACTGTGTTTTCCTG	0.363			NA											63	97					7.37877e-41	1.23973e-40	0.00361	1	0
C18orf34	374864	broad.mit.edu	37	18	30926228	30926228	+	Missense_Mutation	SNP	A	A	T	rs148510384		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:30926228A>T	uc002kxn.2	-	8	747	c.605T>A	c.(604-606)ATT>AAT	p.I202N	C18orf34_uc010xbr.1_Missense_Mutation_p.I202N|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.I202N|C18orf34_uc002kxp.2_Missense_Mutation_p.I202N	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	202	Potential.									ovary(1)	1						CCAAGAGTCAATTTTCATGTT	0.388			NA											5	89					0	0	0.000602	0	0
NOL4	8715	broad.mit.edu	37	18	31538225	31538225	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:31538225G>T	uc010dmi.2	-	7	1443	c.1214C>A	c.(1213-1215)GCC>GAC	p.A405D	NOL4_uc010xbs.1_Missense_Mutation_p.A120D|NOL4_uc002kxr.3_Missense_Mutation_p.A241D|NOL4_uc010xbt.1_Missense_Mutation_p.A331D|NOL4_uc010dmh.2_Missense_Mutation_p.A331D|NOL4_uc010xbu.1_Missense_Mutation_p.A405D|NOL4_uc002kxt.3_Missense_Mutation_p.A405D|NOL4_uc010xbv.1_Missense_Mutation_p.A154D|NOL4_uc010xbw.1_Missense_Mutation_p.A291D	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	405						nucleolus	RNA binding			ovary(3)	3						CAGCCGCTCGGCTTCAACGCC	0.473			NA											69	68					1.55545e-33	2.57863e-33	0.00361	1	0
CDH20	28316	broad.mit.edu	37	18	59174760	59174760	+	Silent	SNP	C	C	A	rs150698717		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:59174760C>A	uc010dps.1	+	5	996	c.984C>A	c.(982-984)CCC>CCA	p.P328P	CDH20_uc002lif.2_Silent_p.P322P	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	328	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				GCACAGATCCCAATTTCCAAG	0.398			NA											28	35					2.12542e-12	2.81322e-12	0.00632	1	0
CDH7	1005	broad.mit.edu	37	18	63430201	63430201	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:63430201G>T	uc002ljz.2	+	2	448	c.123G>T	c.(121-123)GGG>GGT	p.G41G	CDH7_uc002lka.2_Silent_p.G41G|CDH7_uc002lkb.2_Silent_p.G41G	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	41	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TCCAATCAGGGAGGTCCCGGA	0.488			NA											7	48					2.0095e-06	2.32116e-06	0.001984	1	0
NETO1	81832	broad.mit.edu	37	18	70417797	70417797	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:70417797G>T	uc002lkw.2	-	9	1325	c.1041C>A	c.(1039-1041)GGC>GGA	p.G347G	NETO1_uc002lkx.1_Silent_p.G346G|NETO1_uc002lky.1_Silent_p.G347G	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	347	Helical; (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGGAAGTCACGCCAATGACAG	0.453			NA											27	28					1.17739e-12	1.56672e-12	0.005443	1	0
OR4F17	81099	broad.mit.edu	37	19	110702	110702	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:110702G>T	uc002loc.1	+	1	24	c.24G>T	c.(22-24)CTG>CTT	p.L8L	OR4F17_uc002lob.1_Silent_p.L8L	NM_001005240	NP_001005240	Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATTTTTCTGGGTCTCTCTG	0.393			NA											46	407					1.61004e-24	2.51065e-24	0.00361	1	0
SLC25A23	79085	broad.mit.edu	37	19	6458287	6458287	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:6458287C>A	uc002mex.1	-	2	347	c.205G>T	c.(205-207)GAG>TAG	p.E69*	SLC25A23_uc002mev.2_RNA	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	69	Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2						GAAAATTCCTCCAGGTCGAGC	0.587			NA											18	13					3.41278e-10	4.27884e-10	0.00499	1	0
EMR1	2015	broad.mit.edu	37	19	6896442	6896442	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:6896442C>G	uc002mfw.2	+	3	166	c.128C>G	c.(127-129)GCT>GGT	p.A43G	EMR1_uc010dvc.2_Missense_Mutation_p.A43G|EMR1_uc010dvb.2_Missense_Mutation_p.A43G|EMR1_uc010xji.1_Missense_Mutation_p.A43G|EMR1_uc010xjj.1_Missense_Mutation_p.A43G	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	43	Extracellular (Potential).|EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TTGTGCCCAGCTTATGCCACC	0.458			NA											60	59					0	0	0.00361	0	0
PNPLA6	10908	broad.mit.edu	37	19	7620629	7620629	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:7620629C>T	uc010xjq.1	+	26	3298	c.3103C>T	c.(3103-3105)CGG>TGG	p.R1035W	PNPLA6_uc002mgq.1_Missense_Mutation_p.R987W|PNPLA6_uc010xjp.1_Missense_Mutation_p.R960W|PNPLA6_uc002mgr.1_Missense_Mutation_p.R987W|PNPLA6_uc002mgs.2_Missense_Mutation_p.R1025W|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1026	Patatin.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						CACGAAGCAGCGGGCCCGGGA	0.662			NA											20	37					0	0	0.003954	0	0
PRAM1	84106	broad.mit.edu	37	19	8563455	8563455	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:8563455C>T	uc002mkd.2	-	2	1257	c.1237G>A	c.(1237-1239)GCT>ACT	p.A413T	PRAM1_uc002mkc.2_Missense_Mutation_p.A413T	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	461	Pro-rich.						lipid binding|protein binding				0						GGTGTCCCAGCCGCTCCAAAC	0.716			NA											9	21					0	0	0.008291	0	0
MUC16	94025	broad.mit.edu	37	19	9088385	9088385	+	Missense_Mutation	SNP	C	C	A	rs145606635	by1000genomes	TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:9088385C>A	uc002mkp.2	-	1	3634	c.3430G>T	c.(3430-3432)GGC>TGC	p.G1144C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1144	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTAGCAGAGCCAGGATCAGGA	0.463			NA											39	30					2.91434e-09	3.56435e-09	0.004878	1	0
ZNF426	79088	broad.mit.edu	37	19	9639792	9639792	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:9639792C>A	uc002mlq.2	-	8	1193	c.929G>T	c.(928-930)TGT>TTT	p.C310F	ZNF426_uc010dws.2_Missense_Mutation_p.C272F	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	310	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACATTCCTTACATTCATATGG	0.413			NA											40	43					4.14481e-20	6.2865e-20	0.00623	1	0
OR7A17	26333	broad.mit.edu	37	19	14991976	14991977	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:14991976_14991977GG>TT	uc010xob.1	-	1	191_192	c.191_192CC>AA	c.(190-192)TCC>TAA	p.S64*		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					AGGACAGGTTGGAGAGGAAGAA	0.5			NA											33	38					0	0	0.004672	0	0
NCAN	1463	broad.mit.edu	37	19	19337293	19337293	+	Splice_Site	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:19337293A>T	uc002nlz.2	+	7	1172	c.1073_splice	c.e7-2	p.A358_splice	NCAN_uc010ecc.1_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor						axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TTTCTCCCACAGCTCATCACC	0.557			NA											38	49					0	0	0.005524	0	0
SF4	57794	broad.mit.edu	37	19	19389578	19389578	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:19389578C>A	uc002nmh.2	-	11	1558	c.1556G>T	c.(1555-1557)GGC>GTC	p.G519V	SF4_uc002nmf.2_Missense_Mutation_p.G69V|SF4_uc002nmg.2_Missense_Mutation_p.G69V|SF4_uc002nmi.2_Missense_Mutation_p.G309V|SF4_uc002nmj.2_Missense_Mutation_p.G309V|SF4_uc002nme.2_Missense_Mutation_p.G69V	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	519					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						CTTGCCCCGGCCCATCTTTGT	0.597			NA											11	15					0.000978159	0.00104073	0.000978	1	0
ZNF492	57615	broad.mit.edu	37	19	22817218	22817218	+	Translation_Start_Site	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:22817218C>A	uc002nqw.3	+	1	93	c.-151C>A	c.(-153--149)ACCTG>ACATG			NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GCCCTGTGACCTGCAGGTATT	0.607			NA											47	53					3.77016e-25	5.93473e-25	0.003214	1	0
ZNF536	9745	broad.mit.edu	37	19	30934975	30934975	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:30934975A>G	uc002nsu.1	+	2	644	c.506A>G	c.(505-507)CAG>CGG	p.Q169R	ZNF536_uc010edd.1_Missense_Mutation_p.Q169R	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	169	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AGGGCGGCGCAGAAGGGGAAC	0.657			NA											22	15					0	0	0.001882	0	0
NPHS1	4868	broad.mit.edu	37	19	36333029	36333029	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:36333029G>T	uc002oby.2	-	19	2660	c.2660C>A	c.(2659-2661)CCC>CAC	p.P887H	NPHS1_uc010eem.1_5'Flank	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	887	Ig-like C2-type 8.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCTCACCTGGGATCTTGGAG	0.592			NA											15	3					6.72482e-11	8.60433e-11	0.003163	1	0
CYP2S1	29785	broad.mit.edu	37	19	41704752	41704752	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:41704752G>A	uc002opw.2	+	5	848	c.793G>A	c.(793-795)GCA>ACA	p.A265T	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Intron	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	265					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						TTCGGGCCCCGCACGTGACCT	0.647			NA											5	50					0	0	0.001168	0	0
TMEM91	641649	broad.mit.edu	37	19	41889658	41889658	+	Silent	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:41889658A>G	uc002oqk.3	+	4	750	c.399A>G	c.(397-399)GCA>GCG	p.A133A	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_3'UTR|TMEM91_uc010ehq.2_Intron|TMEM91_uc002oql.2_3'UTR|TMEM91_uc010ehr.2_Intron|TMEM91_uc010ehs.2_Intron|TMEM91_uc010eht.2_Intron|BCKDHA_uc002oqm.3_Intron|TMEM91_uc002oqn.2_3'UTR	NM_001098821	NP_001092291	Q6ZNR0	TMM91_HUMAN	transmembrane protein 91 isoform a	133					response to biotic stimulus	integral to membrane					0						TCCAGGGGGCAGGGGCCGCCT	0.692			NA											5	36					0	0	0.004482	0	0
ZNF284	342909	broad.mit.edu	37	19	44591017	44591017	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:44591017G>A	uc002oyg.1	+	5	1602	c.1386G>A	c.(1384-1386)AAG>AAA	p.K462K	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	462	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AATGTGGAAAGAGCTTCAGGT	0.433			NA											33	32					0	0	0.002445	0	0
CCDC61	729440	broad.mit.edu	37	19	46498409	46498409	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:46498409G>T	uc002pdw.2	+	1	71	c.71G>T	c.(70-72)GGG>GTG	p.G24V		NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		CCTCCCGCAGGGGGTAATAGG	0.602			NA											10	8					2.27111e-07	2.66655e-07	0.001368	1	0
SULT2A1	6822	broad.mit.edu	37	19	48382314	48382314	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:48382314C>T	uc002phr.2	-	4	686	c.546G>A	c.(544-546)CTG>CTA	p.L182L		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	182					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		CCTCATAACTCAGTAACAGGA	0.463			NA											39	110					0	0	0.00874	0	0
HRC	3270	broad.mit.edu	37	19	49657521	49657521	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:49657521C>T	uc002pmv.2	-	1	1161	c.974G>A	c.(973-975)AGA>AAA	p.R325K		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	325	4 X tandem repeats, acidic.|2-6.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CTCTTCCTTTCTGTGGTCTTG	0.542	Melanoma(37;75 1097 24567 25669 30645)		NA											10	33					0	0	0.006214	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979642	50979642	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:50979642C>A	uc002psh.2	-	1	362	c.4G>T	c.(4-6)GGG>TGG	p.G2W	FAM71E1_uc002psg.2_Missense_Mutation_p.G2W|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	2										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		AGGGGCGGCCCCATCCTGCTG	0.692			NA											14	18					6.72482e-11	8.60433e-11	0.003163	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51920599	51920599	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:51920599G>T	uc002pwo.2	-	2	774	c.158C>A	c.(157-159)TCT>TAT	p.S53Y	SIGLEC10_uc002pwp.2_Missense_Mutation_p.S53Y|SIGLEC10_uc002pwq.2_Missense_Mutation_p.S53Y|SIGLEC10_uc002pwr.2_Missense_Mutation_p.S53Y|SIGLEC10_uc010ycy.1_Missense_Mutation_p.S53Y|SIGLEC10_uc010ycz.1_Missense_Mutation_p.S53Y|SIGLEC10_uc010eow.2_Intron|SIGLEC10_uc002pws.1_Missense_Mutation_p.S37Y	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	53	Extracellular (Potential).|Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGCTGGGGTAGACCCTGTCCA	0.567			NA											25	25					7.92952e-12	1.03582e-11	0.003954	1	0
SIGLEC12	89858	broad.mit.edu	37	19	52003360	52003360	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:52003360G>T	uc002pwx.1	-	2	678	c.622C>A	c.(622-624)CCA>ACA	p.P208T	SIGLEC12_uc002pww.1_Missense_Mutation_p.P90T|SIGLEC12_uc010eoy.1_Intron	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	208	Ig-like V-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TTTCCACTTGGGGTGTTTGTG	0.537			NA											46	58					3.05275e-18	4.48035e-18	0.003214	1	0
ZNF480	147657	broad.mit.edu	37	19	52817532	52817532	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:52817532G>T	uc010ydl.1	+	3	269	c.199G>T	c.(199-201)GGA>TGA	p.G67*	ZNF480_uc002pyv.2_Intron|ZNF480_uc010ydm.1_Missense_Mutation_p.G67W|ZNF480_uc010epn.2_Intron|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GGTCTCCCTGGGTGAGGATCA	0.527			NA											41	50					2.35958e-20	3.58973e-20	0.009718	1	0
NLRP7	199713	broad.mit.edu	37	19	55452299	55452299	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:55452299C>G	uc002qih.3	-	3	428	c.352G>C	c.(352-354)GGT>CGT	p.G118R	NLRP7_uc002qig.3_Missense_Mutation_p.G118R|NLRP7_uc002qii.3_Missense_Mutation_p.G118R|NLRP7_uc010esk.2_Missense_Mutation_p.G118R|NLRP7_uc010esl.2_Missense_Mutation_p.G146R	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	118							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ATTTACCCACCTGGCTTTGCT	0.423			NA											46	48					0	0	0.00361	0	0
NLRP13	126204	broad.mit.edu	37	19	56424435	56424435	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:56424435G>T	uc010ygg.1	-	5	773	c.748C>A	c.(748-750)CTG>ATG	p.L250M		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	250	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GCCCAGTGCAGCATAGCCTGC	0.502			NA											31	73					5.45727e-16	7.69259e-16	0.008361	1	0
ZIM3	114026	broad.mit.edu	37	19	57646670	57646670	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:57646670G>T	uc002qnz.1	-	5	1421	c.1035C>A	c.(1033-1035)TCC>TCA	p.S345S		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	345	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGGATTTCTGGGAAAAGGCCT	0.398			NA											65	56					6.25564e-26	9.94129e-26	0.00361	1	0
ZNF211	10520	broad.mit.edu	37	19	58152396	58152396	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr19:58152396C>T	uc002qpq.2	+	3	722	c.542C>T	c.(541-543)TCG>TTG	p.S181L	ZNF211_uc010yhb.1_Missense_Mutation_p.S185L|ZNF211_uc002qpp.2_Missense_Mutation_p.S194L|ZNF211_uc002qpr.2_Missense_Mutation_p.S245L|ZNF211_uc002qps.2_Missense_Mutation_p.S246L|ZNF211_uc002qpt.2_Missense_Mutation_p.S193L|ZNF211_uc010yhc.1_Missense_Mutation_p.S193L|ZNF211_uc010yhd.1_Missense_Mutation_p.S120L|ZNF211_uc010yhe.1_Missense_Mutation_p.S172L	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	181						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTCCATGTGTCGGAGAAACCC	0.488			NA											3	52					0	0	0.004672	0	0
SOX11	6664	broad.mit.edu	37	2	5833565	5833565	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:5833565C>A	uc002qyj.2	+	1	767	c.712C>A	c.(712-714)CAG>AAG	p.Q238K		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	238					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		GCTGCAGCTGCAGATCAAACA	0.582			NA											7	3					0.00307968	0.00319493	0.00308	1	0
APOB	338	broad.mit.edu	37	2	21225799	21225799	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:21225799C>A	uc002red.2	-	29	12623	c.12495G>T	c.(12493-12495)CAG>CAT	p.Q4165H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4165					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCTTGAGTCCCTGGAAACTGG	0.473			NA											16	91					1.15088e-07	1.35445e-07	0.004007	1	0
CAPN13	92291	broad.mit.edu	37	2	30993187	30993187	+	Silent	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:30993187G>C	uc002rnn.2	-	5	692	c.516C>G	c.(514-516)GCC>GCG	p.A172A	CAPN13_uc002rnp.1_Silent_p.A172A	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	172	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					ACTTGGCATAGGCCTTCTCCA	0.562			NA											5	46					0	0	0.001168	0	0
NLRC4	58484	broad.mit.edu	37	2	32476123	32476123	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:32476123G>T	uc002roi.2	-	4	1056	c.810C>A	c.(808-810)CGC>CGA	p.R270R	NLRC4_uc002roj.1_Silent_p.R270R|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	270	LRR 2.|NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGTTCTTGAAGCGGTGGTTTT	0.512			NA											13	107					0.00185496	0.00195692	0.001855	1	0
DHX57	90957	broad.mit.edu	37	2	39050281	39050281	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:39050281C>T	uc002rrf.2	-	17	3244	c.3145G>A	c.(3145-3147)GAT>AAT	p.D1049N	DHX57_uc002rrd.3_Missense_Mutation_p.D433N|DHX57_uc002rre.2_Missense_Mutation_p.D482N	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1049							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				AATCTTTCATCTGGAGTTAAT	0.458	Melanoma(191;1090 2095 4375 23729 47341)		NA											15	61					0	0	0.003163	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656780	40656780	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:40656780G>A	uc002rrx.2	-	1	665	c.641C>T	c.(640-642)GCC>GTC	p.A214V	SLC8A1_uc002rry.2_Missense_Mutation_p.A214V|SLC8A1_uc002rrz.2_Missense_Mutation_p.A214V|SLC8A1_uc002rsa.2_Missense_Mutation_p.A214V|SLC8A1_uc002rsd.3_Missense_Mutation_p.A214V|SLC8A1_uc002rsb.1_Missense_Mutation_p.A214V|SLC8A1_uc010fan.1_Missense_Mutation_p.A214V|SLC8A1_uc002rsc.1_Missense_Mutation_p.A214V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	214	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCAGGTGTAGGCAAAGATGCT	0.443			NA											12	45					0	0	0.000978	0	0
FSHR	2492	broad.mit.edu	37	2	49210072	49210072	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:49210072C>G	uc002rww.2	-	8	721	c.647G>C	c.(646-648)GGA>GCA	p.G216A	FSHR_uc002rwx.2_Missense_Mutation_p.G216A|FSHR_uc010fbn.2_Missense_Mutation_p.G190A	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	216	LRR 7.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCCAGAGGCTCCGTGGAAAAC	0.428			NA							Gonadal_Dysgenesis_46_XX				21	31					0	0	0.002299	0	0
CNGA3	1261	broad.mit.edu	37	2	99013344	99013344	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:99013344A>T	uc002syt.2	+	8	2128	c.1711A>T	c.(1711-1713)ATT>TTT	p.I571F	CNGA3_uc002syu.2_Missense_Mutation_p.I553F|CNGA3_uc010fij.2_Missense_Mutation_p.I575F	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	571	cGMP.				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CATCCGCAGCATTGGCTACTC	0.587			NA											14	119					0	0	0.003163	0	0
LOC150776	150776	broad.mit.edu	37	2	132277212	132277212	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:132277212C>T	uc002tsz.3	+	2	669	c.222C>T	c.(220-222)CTC>CTT	p.L74L	LOC150776_uc002tsy.3_RNA					Homo sapiens cDNA FLJ41352 fis, clone BRAWH2014645.												0						AGAACGGACTCATCCTTACGC	0.632			NA											11	25					0	0	0.008291	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290207	132290207	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:132290207G>T	uc002tta.2	+	5	781	c.729G>T	c.(727-729)GGG>GGT	p.G243G	CCDC74A_uc002ttb.2_Silent_p.G177G	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	243										skin(1)	1						CCTGTATGGGGAACAGCCAGC	0.612			NA											44	76					1.15183e-24	1.80743e-24	0.009718	1	0
RAB3GAP1	22930	broad.mit.edu	37	2	135890497	135890497	+	Silent	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:135890497A>T	uc002tuj.2	+	14	1294	c.1269A>T	c.(1267-1269)CCA>CCT	p.P423P	RAB3GAP1_uc010fnf.2_Silent_p.P423P|RAB3GAP1_uc010fng.2_Silent_p.P248P|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	423						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CTGAGAAACCATTAGATGGAA	0.313			NA											22	25					0	0	0.003954	0	0
ZEB2	9839	broad.mit.edu	37	2	145161562	145161562	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:145161562C>A	uc002tvu.2	-	6	1208	c.728G>T	c.(727-729)TGC>TTC	p.C243F	ZEB2_uc002tvv.2_Missense_Mutation_p.C237F|ZEB2_uc010zbm.1_Missense_Mutation_p.C214F|ZEB2_uc010fnp.2_Missense_Mutation_p.C151F|ZEB2_uc010fnq.1_Missense_Mutation_p.C272F	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	243	C2H2-type 2.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ACAGAGAGGGCAGGAAAAGTT	0.532	Melanoma(33;1235 1264 5755 16332)		NA											46	74					4.44401e-20	6.71989e-20	0.002522	1	0
CACNB4	785	broad.mit.edu	37	2	152732955	152732955	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:152732955C>A	uc002tya.2	-	5	574	c.506G>T	c.(505-507)GGA>GTA	p.G169V	CACNB4_uc002txy.2_Missense_Mutation_p.G135V|CACNB4_uc002txz.2_Missense_Mutation_p.G151V|CACNB4_uc010fnz.2_Missense_Mutation_p.G169V|CACNB4_uc002tyb.2_Missense_Mutation_p.G135V	NM_000726	NP_000717	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4	169					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GTGAAAACGTCCTCTTTTTTG	0.418			NA											3	16					1.23904e-05	1.39567e-05	0.000602	1	0
CSRNP3	80034	broad.mit.edu	37	2	166535352	166535352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:166535352C>T	uc002udf.2	+	7	1223	c.847C>T	c.(847-849)CAG>TAG	p.Q283*	CSRNP3_uc002udg.2_Nonsense_Mutation_p.Q283*	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	283					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						AAACCGAGAGCAGCAAATCCC	0.448			NA											18	39					0	0	0.006122	0	0
SCN1A	6323	broad.mit.edu	37	2	166895987	166895987	+	Silent	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:166895987T>A	uc010zcz.1	-	14	2520	c.2502A>T	c.(2500-2502)GTA>GTT	p.V834V	SCN1A_uc002udo.3_Silent_p.V714V|SCN1A_uc010fpk.2_Silent_p.V686V	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	845	II.|Helical; Name=S3 of repeat II; (By similarity).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTCCAAGTTCTACCAGGCTAA	0.358			NA											7	23					0	0	0.00308	0	0
XIRP2	129446	broad.mit.edu	37	2	168104029	168104029	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:168104029C>A	uc002udx.2	+	8	6145	c.6127C>A	c.(6127-6129)CTT>ATT	p.L2043I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.L1868I|XIRP2_uc010fpq.2_Missense_Mutation_p.L1821I|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1868					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GGAGAAAAGCCTTAGAAGACT	0.393			NA											22	32					1.55795e-14	2.17155e-14	0.001882	1	0
LRP2	4036	broad.mit.edu	37	2	170013974	170013974	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:170013974C>G	uc002ues.2	-	64	12139	c.11926G>C	c.(11926-11928)GAG>CAG	p.E3976Q		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3976	EGF-like 14.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAATTTTGCTCGCATATATTT	0.383			NA											4	26					0	0	0.009096	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798438	185798438	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:185798438G>T	uc002uph.2	+	3	958	c.364G>T	c.(364-366)GAG>TAG	p.E122*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	122						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAAGCTGGCTGAGCTAAGAAA	0.408			NA											6	35					0.00198382	0.00207531	0.001984	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801663	185801664	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:185801663_185801664GG>TT	uc002uph.2	+	4	2134_2135	c.1540_1541GG>TT	c.(1540-1542)GGA>TTA	p.G514L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	514						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TTATGAAATTGGAAGTAGCAAA	0.396			NA											32	60					0	0	0.004672	0	0
PPIL3	53938	broad.mit.edu	37	2	201741695	201741695	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:201741695G>T	uc002uwh.2	-	6	547	c.306C>A	c.(304-306)TTC>TTA	p.F102L	PPIL3_uc002uwi.2_Missense_Mutation_p.F106L|PPIL3_uc002uwj.2_Nonsense_Mutation_p.S71*|PPIL3_uc002uwk.2_Missense_Mutation_p.F102L	NM_130906	NP_570981	Q9H2H8	PPIL3_HUMAN	peptidylprolyl isomerase-like 3 isoform PPIL3b	102	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity|protein binding				0						CATAGGTGATGAAGAACTGAG	0.378			NA											5	41					1.024e-07	1.21372e-07	0.000602	1	0
CRYGC	1420	broad.mit.edu	37	2	208993031	208993031	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:208993031C>T	uc002vco.3	-	3	459	c.421G>A	c.(421-423)GGG>AGG	p.G141R		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	141	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		TATTGCCGCCCCCGGTAGTTG	0.632			NA											26	44					0	0	0.003954	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209141553	209141553	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:209141553A>T	uc002vcz.2	+	4	598	c.440A>T	c.(439-441)CAG>CTG	p.Q147L	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Missense_Mutation_p.Q147L|PIKFYVE_uc002vcv.2_Intron|PIKFYVE_uc002vcw.2_Missense_Mutation_p.Q147L|PIKFYVE_uc002vcx.2_Intron	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	147					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GGGAAAAGCCAGGTACTGTCT	0.443			NA											8	24					0	0	0.00308	0	0
CPS1	1373	broad.mit.edu	37	2	211452821	211452821	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:211452821G>T	uc002vee.3	+	7	793	c.661G>T	c.(661-663)GTA>TTA	p.V221L	CPS1_uc010fur.2_Missense_Mutation_p.V227L	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	221	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CACAAAAGTGGTAGCTGTAGA	0.408			NA											12	96					1.05317e-09	1.30405e-09	0.00245	1	0
WNT10A	80326	broad.mit.edu	37	2	219757817	219757817	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:219757817C>A	uc002vjd.1	+	4	1541	c.1078C>A	c.(1078-1080)CGC>AGC	p.R360S		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	360			R -> C (found in a patient with unclassified form of ectodermal dysplasia).		anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACCGTGGGCCGCCTGTGCAA	0.607			NA											15	15					5.03518e-11	6.47566e-11	0.007413	1	0
DNPEP	23549	broad.mit.edu	37	2	220247914	220247914	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:220247914C>A	uc010zlg.1	-	10	981	c.899G>T	c.(898-900)GGC>GTC	p.G300V	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.G292V|DNPEP_uc002vlf.1_Missense_Mutation_p.G278V|DNPEP_uc002vlh.2_Missense_Mutation_p.G239V|DNPEP_uc002vli.1_Missense_Mutation_p.G239V	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	282					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	GGAGCCAGGGCCTGCACAGGA	0.582			NA											10	41					3.86212e-05	4.22631e-05	0.008291	1	0
DNPEP	23549	broad.mit.edu	37	2	220247927	220247927	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:220247927C>G	uc010zlg.1	-	10	968	c.886G>C	c.(886-888)GAT>CAT	p.D296H	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.D288H|DNPEP_uc002vlf.1_Missense_Mutation_p.D274H|DNPEP_uc002vlh.2_Missense_Mutation_p.D235H|DNPEP_uc002vli.1_Missense_Mutation_p.D235H	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	278					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	GCACAGGAATCTATCAAGGCC	0.587			NA											6	35					0	0	0.001168	0	0
DOCK10	55619	broad.mit.edu	37	2	225664932	225664932	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:225664932T>A	uc010fwz.1	-	41	4681	c.4442A>T	c.(4441-4443)AAT>ATT	p.N1481I	DOCK10_uc002vob.2_Missense_Mutation_p.N1475I|DOCK10_uc002voa.2_Missense_Mutation_p.N137I|DOCK10_uc002voc.2_Missense_Mutation_p.N335I	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1481							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CGTAGCTATATTGGCCTCAGT	0.373			NA											3	22					0	0	0.009096	0	0
WDR69	164781	broad.mit.edu	37	2	228754681	228754681	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:228754681G>T	uc002vpn.1	+	3	302	c.223G>T	c.(223-225)GGC>TGC	p.G75C	WDR69_uc010zlw.1_Missense_Mutation_p.G60C|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	75										breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		AGAGAAACTCGGCCAGAACAG	0.358			NA											15	31					2.31682e-05	2.58057e-05	0.003163	1	0
PTMA	5757	broad.mit.edu	37	2	232577179	232577179	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:232577179G>T	uc002vsc.3	+	4	423	c.241G>T	c.(241-243)GAG>TAG	p.E81*	PTMA_uc002vsb.3_Nonsense_Mutation_p.E80*|PTMA_uc010zmf.1_RNA|MIR1244_hsa-mir-1244-1|MI0006379_5'Flank	NM_001099285	NP_001092755	P06454	PTMA_HUMAN	prothymosin, alpha isoform 1	81	Asp/Glu-rich (acidic).				transcription, DNA-dependent	nucleus					0		Renal(207;0.0112)|all_hematologic(139;0.0315)|Acute lymphoblastic leukemia(138;0.0921)|all_lung(227;0.142)		Epithelial(121;1.75e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00221)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		AGATGAAGATGAGGAAGCTGA	0.557			NA											14	19					1.62849e-17	2.36226e-17	0.004007	1	0
GAL3ST2	64090	broad.mit.edu	37	2	242738535	242738535	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:242738535G>A	uc002wcj.1	+	2	216	c.85G>A	c.(85-87)GGA>AGA	p.G29R		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	29	Helical; Signal-anchor for type II membrane protein; (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CCTGCTGGCCGGATTCCTGCA	0.632			NA											31	36					0	0	0.002445	0	0
CHGB	1114	broad.mit.edu	37	20	5903171	5903171	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:5903171C>T	uc002wmg.2	+	4	687	c.381C>T	c.(379-381)GGC>GGT	p.G127G	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	127						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CAGAGGGAGGCGGGCACAGCC	0.617			NA											15	10					0	0	0.00499	0	0
BPIL1	80341	broad.mit.edu	37	20	31606157	31606157	+	Splice_Site	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:31606157G>A	uc002wyj.2	+	8	863	c.669_splice	c.e8+1	p.N223_splice		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing							extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GGAAGTCAATGTAAGTGCCTC	0.572			NA											43	14					0	0	0.002522	0	0
RBM12	10137	broad.mit.edu	37	20	34241416	34241416	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:34241416T>C	uc002xdq.2	-	3	2061	c.1829A>G	c.(1828-1830)AAT>AGT	p.N610S	CPNE1_uc010zvj.1_Intron|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Missense_Mutation_p.N610S|RBM12_uc002xds.2_Missense_Mutation_p.N610S	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	610						nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TTCTCTCCCATTAAGTTTTTT	0.403			NA											122	77					0	0	0.00361	0	0
ADA	100	broad.mit.edu	37	20	43251662	43251662	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:43251662C>T	uc002xmj.2	-	7	792	c.664G>A	c.(664-666)GAA>AAA	p.E222K	ADA_uc010ggt.2_RNA	NM_000022	NP_000013	P00813	ADA_HUMAN	adenosine deaminase	222					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			pancreas(2)|ovary(1)	3		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	TTTACTACTTCGGCCGAGCCC	0.627			NA							Adenosine_Deaminase_Deficiency				25	74					0	0	0.003954	0	0
EYA2	2139	broad.mit.edu	37	20	45797789	45797789	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:45797789T>G	uc002xsm.2	+	11	1355	c.981T>G	c.(979-981)GAT>GAG	p.D327E	EYA2_uc010ghp.2_Missense_Mutation_p.D327E|EYA2_uc002xsn.2_Missense_Mutation_p.D332E|EYA2_uc002xso.2_Missense_Mutation_p.D327E|EYA2_uc002xsp.2_Missense_Mutation_p.D327E|EYA2_uc002xsq.2_Missense_Mutation_p.D297E	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	327					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				TTCCATAGGATTGTGACCAGA	0.353	Pancreas(120;56 1725 18501 25218 43520)		NA											10	110					0	0	0.006214	0	0
CASS4	57091	broad.mit.edu	37	20	55027328	55027328	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:55027328C>A	uc002xxp.2	+	6	1321	c.1096C>A	c.(1096-1098)CTG>ATG	p.L366M	CASS4_uc002xxq.3_Missense_Mutation_p.L366M|CASS4_uc002xxr.2_Missense_Mutation_p.L366M|CASS4_uc010zze.1_Missense_Mutation_p.L312M|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	366					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						TGGGAAGGAGCTGGAGAAAGC	0.502			NA											35	22					2.47316e-13	3.35355e-13	0.003271	1	0
STX16	8675	broad.mit.edu	37	20	57246287	57246287	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:57246287G>T	uc002xzi.2	+	7	1461	c.726G>T	c.(724-726)CAG>CAT	p.Q242H	STX16_uc010zzq.1_Missense_Mutation_p.Q56H|STX16_uc002xzk.2_Missense_Mutation_p.Q225H|STX16_uc002xzm.2_Missense_Mutation_p.Q238H|STX16_uc002xzj.2_Missense_Mutation_p.Q221H|STX16_uc002xzl.2_Missense_Mutation_p.Q56H	NM_001001433	NP_001001433	O14662	STX16_HUMAN	syntaxin 16 isoform a	242	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			ovary(1)	1	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			AGATTCGCCAGATTGTACAGT	0.478			NA											49	34					4.64027e-19	6.93261e-19	0.00361	1	0
KCNQ2	3785	broad.mit.edu	37	20	62038292	62038292	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:62038292C>A	uc002yey.1	-	17	2501	c.2324G>T	c.(2323-2325)AGG>ATG	p.R775M	KCNQ2_uc002yez.1_Missense_Mutation_p.R744M|KCNQ2_uc002yfa.1_Missense_Mutation_p.R757M|KCNQ2_uc002yfb.1_Missense_Mutation_p.R747M	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	775	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CTCGGGGGGCCTGCAGCCCGG	0.711			NA											5	8					3.59834e-05	3.94631e-05	0.001168	1	0
TPTE	7179	broad.mit.edu	37	21	10914415	10914415	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:10914415A>G	uc002yip.1	-	21	1672	c.1304T>C	c.(1303-1305)ATA>ACA	p.I435T	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.I417T|TPTE_uc002yir.1_Missense_Mutation_p.I397T|TPTE_uc010gkv.1_Missense_Mutation_p.I297T	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	435	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTCCATTTCTATTTGGATTTT	0.318			NA											7	34					0	0	0.001984	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28306833	28306833	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:28306833G>A	uc002ymg.2	-	4	2370	c.1641C>T	c.(1639-1641)ATC>ATT	p.I547I		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	547	Disintegrin.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CCTGCAGGCAGATTCTCCCCT	0.517	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											31	53					0	0	0.003271	0	0
GRIK1	2897	broad.mit.edu	37	21	30925934	30925934	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:30925934C>T	uc002yno.1	-	17	3163	c.2699G>A	c.(2698-2700)GGT>GAT	p.G900D	GRIK1_uc002ynn.2_Intron|GRIK1_uc011acs.1_Intron|GRIK1_uc011act.1_Intron	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	900	Cytoplasmic (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AATTAATTTACCACATTCTAA	0.368			NA											53	66					0	0	0.00361	0	0
KRTAP6-3	337968	broad.mit.edu	37	21	31964873	31964873	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:31964873T>A	uc002yom.2	+	1	115	c.109T>A	c.(109-111)TGT>AGT	p.C37S		NM_181605	NP_853636			keratin associated protein 6-3												0						ttatggcggctgtggctatgg	0.139			NA											18	66					0	0	0.007413	0	0
HUNK	30811	broad.mit.edu	37	21	33296855	33296855	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:33296855C>G	uc002yph.2	+	2	697	c.337C>G	c.(337-339)CAG>GAG	p.Q113E		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	113	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						GCGAGAGGGTCAGATCCAGCA	0.483			NA											5	54					0	0	0.006214	0	0
HUNK	30811	broad.mit.edu	37	21	33296872	33296872	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:33296872C>T	uc002yph.2	+	2	714	c.354C>T	c.(352-354)ATC>ATT	p.I118I		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	118	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						AGCAGATGATCCGCCACCCCA	0.493			NA											6	64					0	0	0.008291	0	0
HUNK	30811	broad.mit.edu	37	21	33296887	33296887	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:33296887C>T	uc002yph.2	+	2	729	c.369C>T	c.(367-369)ATC>ATT	p.I123I		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	123	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						ACCCCAATATCACTCAGCTCC	0.478			NA											8	70					0	0	0.001368	0	0
HUNK	30811	broad.mit.edu	37	21	33296935	33296935	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:33296935C>T	uc002yph.2	+	2	777	c.417C>T	c.(415-417)GTC>GTT	p.V139V		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	139	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						ACTACCTGGTCATGGAGCTGT	0.532			NA											20	115					0	0	0.010504	0	0
HUNK	30811	broad.mit.edu	37	21	33296974	33296974	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:33296974C>A	uc002yph.2	+	2	816	c.456C>A	c.(454-456)ATC>ATA	p.I152I		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	152	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						TGCACAAGATCTATGAGAAGA	0.562			NA											18	131					1.67942e-08	2.00966e-08	0.006122	1	0
HUNK	30811	broad.mit.edu	37	21	33297031	33297031	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:33297031C>T	uc002yph.2	+	2	873	c.513C>T	c.(511-513)ATC>ATT	p.I171I		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	171	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						GACAGCTCATCTCTGCCGTAG	0.627			NA											20	130					0	0	0.001882	0	0
IGSF5	150084	broad.mit.edu	37	21	41137706	41137706	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:41137706C>A	uc002yyo.2	+	3	448	c.345C>A	c.(343-345)CCC>CCA	p.P115P		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	115	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				ATGTGGAGCCCAGTGATTCGG	0.557			NA											15	20					2.31682e-05	2.58057e-05	0.003163	1	0
COL18A1	80781	broad.mit.edu	37	21	46875678	46875678	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr21:46875678C>T	uc011afs.1	+	1	255	c.234C>T	c.(232-234)GGC>GGT	p.G78G	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.G78G	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	78					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CAGCCCCTGGCAGCCCTGAGC	0.672			NA											21	116					0	0	0.008871	0	0
OR11H1	81061	broad.mit.edu	37	22	16449042	16449042	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr22:16449042T>G	uc011agd.1	-	1	763	c.763A>C	c.(763-765)ACC>CCC	p.T255P		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	255	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		GACCCACAGGTAGAGAAGGCC	0.438			NA											56	97					0	0	0.00361	0	0
CLTCL1	8218	broad.mit.edu	37	22	19175557	19175557	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr22:19175557C>T	uc002zpb.2	-	29	4445	c.4370G>A	c.(4369-4371)AGC>AAC	p.S1457N	CLTCL1_uc011agv.1_Missense_Mutation_p.S1457N|CLTCL1_uc011agw.1_Missense_Mutation_p.S1436N|CLTCL1_uc011agt.1_Missense_Mutation_p.S248N|CLTCL1_uc011agu.1_Intron	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1457	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					GTTGTTGTGGCTCTGGACTGA	0.582			NA	T	?	ALCL								38	138					0	0	0.007835	0	0
MN1	4330	broad.mit.edu	37	22	28196322	28196322	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr22:28196322G>T	uc003adj.2	-	1	1165	c.210C>A	c.(208-210)TTC>TTA	p.F70L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	70							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CGCGCGCGTGGAAGCCGTAGG	0.692			NA	T	ETV6	AML|meningioma								14	34					9.31168e-06	1.06085e-05	0.001855	1	0
RFPL3	10738	broad.mit.edu	37	22	32754369	32754369	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr22:32754369A>G	uc003amj.2	+	1	516	c.311A>G	c.(310-312)AAG>AGG	p.K104R	RFPL3_uc010gwn.2_Missense_Mutation_p.K75R	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	104							zinc ion binding			ovary(1)	1						TCCCACATCAAGGAACTGGAG	0.522			NA											21	88					0	0	0.008871	0	0
SYN3	8224	broad.mit.edu	37	22	32914151	32914151	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr22:32914151T>C	uc003amx.2	-	12	1648	c.1489A>G	c.(1489-1491)AAC>GAC	p.N497D	SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Missense_Mutation_p.N496D|SYN3_uc011amc.1_Missense_Mutation_p.N131D	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	497	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						GAGGCCTGGTTTGGGGAGCTG	0.667			NA											10	97					0	0	0.001855	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660931	50660931	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr22:50660931C>T	uc003bkb.1	-	14	2873	c.2361G>A	c.(2359-2361)CTG>CTA	p.L787L	TUBGCP6_uc003bka.1_5'Flank|TUBGCP6_uc010har.1_Silent_p.L779L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	787					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGCACTCTCCAGTCGGTGCC	0.572			NA											18	49					0	0	0.00499	0	0
CHL1	10752	broad.mit.edu	37	3	396435	396435	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:396435C>A	uc003bou.2	+	10	1369	c.1098C>A	c.(1096-1098)GTC>GTA	p.V366V	CHL1_uc003bot.2_Silent_p.V382V|CHL1_uc003bow.1_Silent_p.V366V|CHL1_uc011asi.1_Silent_p.V382V	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	366	Ig-like C2-type 4.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGTGGAGAGTCAATGGCTCCC	0.463			NA											17	49					2.48551e-13	3.36116e-13	0.00499	1	0
MTMR14	64419	broad.mit.edu	37	3	9719695	9719695	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:9719695C>T	uc003brz.2	+	9	974	c.850C>T	c.(850-852)CCC>TCC	p.P284S	MTMR14_uc003bsa.2_Missense_Mutation_p.P284S|MTMR14_uc003bsb.2_Missense_Mutation_p.P284S|MTMR14_uc011ath.1_Intron|MTMR14_uc010hcl.2_Intron|MTMR14_uc003bsc.2_RNA	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	284						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					ATTGAGCATCCCCGACTTCCT	0.557			NA											18	53					0	0	0.001882	0	0
CNOT10	25904	broad.mit.edu	37	3	32746360	32746360	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:32746360G>A	uc003cfc.1	+	3	430	c.175G>A	c.(175-177)GAT>AAT	p.D59N	CNOT10_uc011axi.1_5'UTR|CNOT10_uc003cfd.1_Missense_Mutation_p.D59N|CNOT10_uc003cfe.1_Missense_Mutation_p.D59N|CNOT10_uc010hfv.1_Intron|CNOT10_uc011axj.1_Missense_Mutation_p.D119N|CNOT10_uc010hfw.1_5'UTR	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	59					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						TATAAACAAAGATGATTATAA	0.313			NA											12	30					0	0	0.001368	0	0
ARPP21	10777	broad.mit.edu	37	3	35778828	35778828	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:35778828C>A	uc003cgb.2	+	16	1882	c.1618C>A	c.(1618-1620)CAG>AAG	p.Q540K	ARPP21_uc003cga.2_Missense_Mutation_p.Q486K|ARPP21_uc011axy.1_Missense_Mutation_p.Q506K|ARPP21_uc003cgf.2_Missense_Mutation_p.Q341K|ARPP21_uc003cgg.2_Missense_Mutation_p.Q28K	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	540	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						ACCGCAGCCACAGATGGCAGG	0.647			NA											7	28					0.00307968	0.00319493	0.00308	1	0
DCLK3	85443	broad.mit.edu	37	3	36779106	36779106	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:36779106C>A	uc003cgi.2	-	2	1536	c.1045G>T	c.(1045-1047)GCC>TCC	p.A349S		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	349						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						ACATTGGCGGCAATGATGCCC	0.582			NA											13	81					0.00010058	0.000109107	0.001368	1	0
TRANK1	9881	broad.mit.edu	37	3	36874113	36874113	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:36874113G>C	uc003cgj.2	-	12	5481	c.5179C>G	c.(5179-5181)CGC>GGC	p.R1727G		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2277					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CGGCGGTTGCGTGCGCTTTCA	0.478			NA											18	32					0	0	0.00499	0	0
RHOA	387	broad.mit.edu	37	3	49405963	49405963	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:49405963C>T	uc003cwu.2	-	3	451	c.175G>A	c.(175-177)GAC>AAC	p.D59N	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	59	GTP (By similarity).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	CCAGCTGTGTCCCACAAAGCC	0.463			NA											8	48					0	0	0.00308	0	0
GLT8D1	55830	broad.mit.edu	37	3	52731792	52731792	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:52731792G>A	uc003dfi.3	-	4	413	c.274C>T	c.(274-276)CGC>TGC	p.R92C	GLT8D1_uc003dfj.2_Missense_Mutation_p.R92C|GLT8D1_uc003dfk.2_Missense_Mutation_p.R92C|GLT8D1_uc003dfl.2_Missense_Mutation_p.R92C|GLT8D1_uc003dfm.2_Missense_Mutation_p.R92C|GLT8D1_uc003dfn.2_Missense_Mutation_p.R92C|GLT8D1_uc003dfo.1_Missense_Mutation_p.R92C	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	92	Lumenal (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACATTGGAGCGAGTGTTGTGC	0.468			NA											25	51					0	0	0.003954	0	0
FOXP1	27086	broad.mit.edu	37	3	71021723	71021723	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:71021723C>A	uc003dol.2	-	14	1958	c.1635G>T	c.(1633-1635)AGG>AGT	p.R545S	FOXP1_uc003dom.2_Missense_Mutation_p.R469S|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.R544S|FOXP1_uc003dop.2_Missense_Mutation_p.R545S|FOXP1_uc003doq.1_Intron|FOXP1_uc003doi.2_Missense_Mutation_p.R445S|FOXP1_uc003doj.2_Missense_Mutation_p.R445S|FOXP1_uc003dok.2_Missense_Mutation_p.R358S|FOXP1_uc003dor.1_Missense_Mutation_p.R322S	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	545	Fork-head.				cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TCTTTTGTGGCCTTCGTTTTT	0.433			NA	T	PAX5	ALL								20	68					0.000229342	0.000247709	0.001882	1	0
EPHA6	285220	broad.mit.edu	37	3	96706499	96706499	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:96706499G>T	uc010how.1	+	3	819	c.776G>T	c.(775-777)CGC>CTC	p.R259L	EPHA6_uc003drp.1_Missense_Mutation_p.R259L	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	164	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TTGGGTGATCGCATCCTCAAA	0.443			NA											66	153					7.73544e-29	1.24919e-28	0.00361	1	0
EPHA6	285220	broad.mit.edu	37	3	96706738	96706738	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:96706738A>T	uc010how.1	+	3	1058	c.1015A>T	c.(1015-1017)ACT>TCT	p.T339S	EPHA6_uc003drp.1_Missense_Mutation_p.T339S	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	244	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						AGAGCGTGACACTCCTAAACT	0.473			NA											23	74					0	0	0.002299	0	0
RHO	6010	broad.mit.edu	37	3	129251193	129251193	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:129251193C>T	uc003emt.2	+	3	725	c.630C>T	c.(628-630)GTC>GTT	p.V210V		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	210	Retinal chromophore binding (By similarity).|Helical; Name=5; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TGTTCGTGGTCCACTTCACCA	0.567	Esophageal Squamous(118;214 1623 30842 43234 46940)		NA											22	67					0	0	0.001882	0	0
COL6A6	131873	broad.mit.edu	37	3	130279226	130279226	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:130279226G>T	uc010htl.2	+	1	49	c.18G>T	c.(16-18)TTG>TTT	p.L6F		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	6					axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TGCTAATTTTGTTCCTCGTGA	0.279			NA											9	22					1.76689e-08	2.10928e-08	0.006214	1	0
NLGN1	22871	broad.mit.edu	37	3	173998981	173998981	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:173998981C>G	uc003fio.1	+	7	2783	c.2360C>G	c.(2359-2361)ACT>AGT	p.T787S	NLGN1_uc003fip.1_Missense_Mutation_p.T787S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	804	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATTCCCAACACTATACCAGGG	0.483			NA											19	51					0	0	0.010504	0	0
PEX5L	51555	broad.mit.edu	37	3	179525601	179525602	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:179525601_179525602GG>TT	uc003fki.1	-	14	1666_1667	c.1536_1537CC>AA	c.(1534-1539)AACCGC>AAAAGC	p.512_513NR>KS	PEX5L_uc011bqd.1_Missense_Mutation_p.469_470NR>KS|PEX5L_uc011bqe.1_Missense_Mutation_p.320_321NR>KS|PEX5L_uc011bqf.1_Missense_Mutation_p.404_405NR>KS|PEX5L_uc003fkj.1_Missense_Mutation_p.477_478NR>KS|PEX5L_uc010hxd.1_Missense_Mutation_p.510_511NR>KS|PEX5L_uc011bqg.1_Missense_Mutation_p.488_489NR>KS|PEX5L_uc011bqh.1_Missense_Mutation_p.453_454NR>KS	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	512_513	TPR 4.				protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GCCCCGAGGCGGTTCCATAGTG	0.52			NA											30	100					0	0	0.004672	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043403	184043403	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:184043403G>A	uc003fnp.2	+	20	3295	c.3097G>A	c.(3097-3099)GGC>AGC	p.G1033S	EIF4G1_uc003fnt.2_Missense_Mutation_p.G744S|EIF4G1_uc003fnq.2_Missense_Mutation_p.G946S|EIF4G1_uc003fnr.2_Missense_Mutation_p.G869S|EIF4G1_uc010hxx.2_Missense_Mutation_p.G1040S|EIF4G1_uc003fns.2_Missense_Mutation_p.G993S|EIF4G1_uc010hxy.2_Missense_Mutation_p.G1040S|EIF4G1_uc003fnv.3_Missense_Mutation_p.G1034S|EIF4G1_uc003fnu.3_Missense_Mutation_p.G1033S|EIF4G1_uc003fnw.2_Missense_Mutation_p.G1040S|EIF4G1_uc003fnx.2_Missense_Mutation_p.G838S|EIF4G1_uc003fny.3_Missense_Mutation_p.G837S|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1033	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAAGCGTCGGGGCGGTCCTCC	0.547			NA											15	97					0	0	0.003163	0	0
CHRD	8646	broad.mit.edu	37	3	184099529	184099529	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:184099529G>A	uc003fov.2	+	5	783	c.537G>A	c.(535-537)CCG>CCA	p.P179P	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Silent_p.P179P|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	179	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGACAGGGCCGAGGTCGCAGG	0.647			NA											4	28					0	0	0.001168	0	0
LSG1	55341	broad.mit.edu	37	3	194387265	194387265	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:194387265C>T	uc003fui.2	-	3	578	c.263G>A	c.(262-264)AGA>AAA	p.R88K		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	88					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		TAGTCCAGTTCTAGCCTCAGC	0.383			NA											10	62					0	0	0.006214	0	0
IQCG	84223	broad.mit.edu	37	3	197616455	197616456	+	Missense_Mutation	DNP	TT	TT	CA			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:197616455_197616456TT>CA	uc003fyo.2	-	11	1473_1474	c.1327_1328AA>TG	c.(1327-1329)AAG>TGG	p.K443W	IQCG_uc003fyn.2_Missense_Mutation_p.K345W|IQCG_uc003fyp.2_Missense_Mutation_p.K443W|IQCG_uc003fym.2_Missense_Mutation_p.K144W	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	443											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		ACTTGGTCACTTCTTCTTGCCT	0.426			NA											38	96					0	0	0.004672	0	0
OTOP1	133060	broad.mit.edu	37	4	4190545	4190545	+	Silent	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:4190545G>C	uc003ghp.1	-	6	1854	c.1824C>G	c.(1822-1824)GTC>GTG	p.V608V		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	608					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCTTACAATAGACCTCAAAGA	0.463			NA											16	39					0	0	0.007413	0	0
CPZ	8532	broad.mit.edu	37	4	8605750	8605750	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:8605750T>G	uc003glm.2	+	4	670	c.544T>G	c.(544-546)TTC>GTC	p.F182V	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.F45V|CPZ_uc003glo.2_Missense_Mutation_p.F171V|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	182					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCCGCCCACCTTCATCCGCTT	0.701			NA											8	36					0	0	0.008291	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401447	11401447	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:11401447G>T	uc003gmq.2	-	2	506	c.183C>A	c.(181-183)GGC>GGA	p.G61G		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	61						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						CCTTGCGCACGCCGATGATGA	0.677			NA											23	38					1.64293e-13	2.24609e-13	0.00333	1	0
BOD1L	259282	broad.mit.edu	37	4	13604380	13604380	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:13604380C>A	uc003gmz.1	-	10	4261	c.4144G>T	c.(4144-4146)GTA>TTA	p.V1382L	BOD1L_uc010idr.1_Missense_Mutation_p.V719L	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1382							DNA binding			ovary(5)|breast(1)	6						GGCATGATTACCTTTCCTTGT	0.413			NA											39	61					1.67305e-13	2.28101e-13	0.00623	1	0
FGFBP2	83888	broad.mit.edu	37	4	15964579	15964579	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:15964579C>A	uc003gon.2	-	1	281	c.174G>T	c.(172-174)TGG>TGT	p.W58C		NM_031950	NP_114156	Q9BYJ0	FGFP2_HUMAN	killer-specific secretory protein of 37 kDa	58						extracellular space	growth factor binding				0						CGACACGAAGCCAGACTTCTC	0.577			NA											26	33					4.72057e-08	5.60849e-08	0.003954	1	0
PHOX2B	8929	broad.mit.edu	37	4	41747870	41747870	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:41747870C>G	uc003gwf.3	-	3	1259	c.899G>C	c.(898-900)AGA>ACA	p.R300T		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	300					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						ACCGTTGGGTCTTTGGAGCGA	0.557			NA	Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				14	16					0	0	0.00499	0	0
KCTD8	386617	broad.mit.edu	37	4	44450140	44450140	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:44450140G>T	uc003gwu.2	-	1	685	c.401C>A	c.(400-402)GCC>GAC	p.A134D		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	134						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						GAAATACTCGGCCTCGCGCAG	0.617			NA								HNSCC(17;0.042)			6	33					3.59834e-05	3.94631e-05	0.001168	1	0
ATP10D	57205	broad.mit.edu	37	4	47537986	47537986	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:47537986A>T	uc003gxk.1	+	7	1115	c.951A>T	c.(949-951)AGA>AGT	p.R317S	ATP10D_uc003gxl.1_5'Flank|ATP10D_uc003gxj.3_Missense_Mutation_p.R317S	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	317	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TAGAAAGAAGAGCAAACACAG	0.413			NA											34	55					0	0	0.004878	0	0
POLR2B	5431	broad.mit.edu	37	4	57889625	57889625	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:57889625G>C	uc003hcl.1	+	19	2688	c.2645G>C	c.(2644-2646)AGC>ACC	p.S882T	POLR2B_uc011cae.1_Missense_Mutation_p.S875T|POLR2B_uc011caf.1_Missense_Mutation_p.S807T|POLR2B_uc003hcm.1_Missense_Mutation_p.S375T	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	882					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GAATTGGAGAGCACCAATAGA	0.438			NA											13	76					0	0	0.001855	0	0
EPHA5	2044	broad.mit.edu	37	4	66361122	66361123	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:66361122_66361123GG>TT	uc003hcy.2	-	4	1242_1243	c.1049_1050CC>AA	c.(1048-1050)CCC>CAA	p.P350Q	EPHA5_uc003hcx.2_Missense_Mutation_p.P281Q|EPHA5_uc003hcz.2_Missense_Mutation_p.P350Q|EPHA5_uc011cah.1_Missense_Mutation_p.P350Q|EPHA5_uc011cai.1_Missense_Mutation_p.P350Q|EPHA5_uc003hda.2_Missense_Mutation_p.P350Q	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	350	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ATGCCATTGTGGGTGGATCAGA	0.45			NA								TSP Lung(17;0.13)			31	146					0	0	0.004672	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68784900	68784900	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:68784900G>T	uc003hdr.1	-	8	873	c.752C>A	c.(751-753)CCT>CAT	p.P251H	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.P248H	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	251	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						CATTAAGGGAGGGTTGATTTT	0.368	NSCLC(26;2 894 10941 14480 22546)		NA											31	62					3.86903e-22	5.97723e-22	0.002836	1	0
ENAM	10117	broad.mit.edu	37	4	71510165	71510165	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:71510165A>C	uc011caw.1	+	9	3303	c.3022A>C	c.(3022-3024)AAT>CAT	p.N1008H		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	1008					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			CAACCAGCTCAATGAAAGAAC	0.418			NA											47	67					0	0	0.00361	0	0
GC	2638	broad.mit.edu	37	4	72629540	72629540	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:72629540G>T	uc003hge.2	-	5	740	c.587C>A	c.(586-588)ACT>AAT	p.T196N	GC_uc003hgd.2_Missense_Mutation_p.T74N|GC_uc010iie.2_Missense_Mutation_p.T196N|GC_uc010iif.2_Missense_Mutation_p.T215N	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	196	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	AAAGCATACAGTTGGGCTTGC	0.358			NA											41	78					2.95478e-19	4.42773e-19	0.00874	1	0
ANKRD17	26057	broad.mit.edu	37	4	73984516	73984516	+	Silent	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:73984516T>C	uc003hgp.2	-	22	4194	c.4077A>G	c.(4075-4077)CTA>CTG	p.L1359L	ANKRD17_uc003hgo.2_Silent_p.L1246L|ANKRD17_uc003hgq.2_Silent_p.L1108L|ANKRD17_uc003hgr.2_Silent_p.L1358L|ANKRD17_uc011cbd.1_Silent_p.L924L	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1359	ANK 24.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CATTTGCTGCTAGCCACAATG	0.428			NA											75	114					0	0	0.00361	0	0
NUDT9	53343	broad.mit.edu	37	4	88356226	88356226	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:88356226G>A	uc003hqq.2	+	2	524	c.201G>A	c.(199-201)ACG>ACA	p.T67T	NUDT9_uc003hqr.2_Silent_p.T17T|NUDT9_uc010ikl.2_Silent_p.T67T	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	67						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		AGGCTCGGACGTCTCCTTACC	0.443			NA											9	34					0	0	0.004482	0	0
ABCG2	9429	broad.mit.edu	37	4	89013502	89013502	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:89013502C>T	uc003hrg.2	-	16	2345	c.1852G>A	c.(1852-1854)GGC>AGC	p.G618S	ABCG2_uc003hrh.2_3'UTR|ABCG2_uc003hrf.2_Missense_Mutation_p.G486S	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	618	ABC transmembrane type-2.|Extracellular (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	AGATCGATGCCCTGCTTTACC	0.393			NA											26	38					0	0	0.00632	0	0
MMRN1	22915	broad.mit.edu	37	4	90874233	90874233	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:90874233C>A	uc003hst.2	+	8	3422	c.3351C>A	c.(3349-3351)ATC>ATA	p.I1117I	MMRN1_uc010iku.2_Silent_p.I420I|MMRN1_uc011cds.1_Silent_p.I859I	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1117	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CTGGTCCTATCCTGTTTAATA	0.363			NA											18	88					3.41278e-10	4.27884e-10	0.00499	1	0
RAP1GDS1	5910	broad.mit.edu	37	4	99358165	99358165	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:99358165G>A	uc003htx.3	+	14	1832	c.1642G>A	c.(1642-1644)GCT>ACT	p.A548T	RAP1GDS1_uc003htw.3_Missense_Mutation_p.A549T|RAP1GDS1_uc003htv.3_Missense_Mutation_p.A548T|RAP1GDS1_uc003htz.3_Missense_Mutation_p.A499T|RAP1GDS1_uc003hty.3_Missense_Mutation_p.A500T|RAP1GDS1_uc003hua.3_Missense_Mutation_p.A457T	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	548							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TGAGAGAAGTGCTCCTGAAAT	0.353			NA	T	NUP98	T-ALL								20	43					0	0	0.007413	0	0
NHEDC2	133308	broad.mit.edu	37	4	103979105	103979105	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:103979105C>A	uc003hwx.3	-	4	1167	c.295G>T	c.(295-297)GCT>TCT	p.A99S	NHEDC2_uc010iln.1_5'UTR|NHEDC2_uc003hwy.2_Missense_Mutation_p.A99S|NHEDC2_uc011cew.1_Intron|NHEDC2_uc011cex.1_Intron|NHEDC2_uc011cey.1_Intron	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	99	Helical; (Potential).				sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		CAAACTACAGCCCACAGAAGA	0.343			NA											57	111					9.40535e-28	1.50425e-27	0.00361	1	0
SYNPO2	171024	broad.mit.edu	37	4	119978890	119978890	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:119978890G>T	uc010inb.2	+	5	3783	c.3587G>T	c.(3586-3588)AGG>ATG	p.R1196M	SYNPO2_uc011cgh.1_3'UTR|SYNPO2_uc010inc.2_Missense_Mutation_p.R1066M	NM_133477	NP_597734	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform a	Error:Variant_position_missing_in_Q9UMS6_after_alignment						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TCATGTGGAAGGCAAGAGTAT	0.458			NA											32	128					3.1745e-13	4.26974e-13	0.008361	1	0
LRBA	987	broad.mit.edu	37	4	151271175	151271175	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:151271175A>G	uc010ipj.2	-	49	7838	c.7364T>C	c.(7363-7365)CTG>CCG	p.L2455P	LRBA_uc010ipi.2_Intron|LRBA_uc003ils.3_Missense_Mutation_p.L345P|LRBA_uc003ilt.3_Missense_Mutation_p.L1103P|LRBA_uc003ilu.3_Missense_Mutation_p.L2444P	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2455	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TATTGAATTCAGATTGACAGC	0.338			NA											3	61					0	0	0.009096	0	0
DCHS2	54798	broad.mit.edu	37	4	155191130	155191130	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:155191130C>A	uc003inw.2	-	19	5134	c.5134G>T	c.(5134-5136)GAC>TAC	p.D1712Y		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1712	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGAATTGAGTCAGGAGCAAAA	0.343			NA											35	45					6.70999e-13	9.00076e-13	0.004289	1	0
FGA	2243	broad.mit.edu	37	4	155505648	155505648	+	Silent	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:155505648C>G	uc003iod.1	-	6	2287	c.2229G>C	c.(2227-2229)CGG>CGC	p.R743R		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	743	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CAGAGCCTACCCGGAAGTGAT	0.522	NSCLC(143;340 1922 20892 22370 48145)		NA											69	121					0	0	0.00361	0	0
HAND2	9464	broad.mit.edu	37	4	174450181	174450181	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:174450181G>T	uc003ith.1	-	1	1198	c.260C>A	c.(259-261)GCC>GAC	p.A87D	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Intron|HAND2_uc010ire.1_Missense_Mutation_p.A87D	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	87					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		cgggggcccggcgcccggcgg	0.502			NA											8	4					0.000442599	0.000474961	0.006214	1	0
ADAM29	11086	broad.mit.edu	37	4	175898055	175898055	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:175898055A>T	uc003iuc.2	+	5	2049	c.1379A>T	c.(1378-1380)AAT>ATT	p.N460I	ADAM29_uc003iud.2_Missense_Mutation_p.N460I|ADAM29_uc010irr.2_Missense_Mutation_p.N460I|ADAM29_uc011cki.1_Missense_Mutation_p.N460I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	460	Disintegrin.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AAGGAGGTCAATGAATGTGAT	0.453	Ovarian(140;1727 1835 21805 25838 41440)		NA											49	76					0	0	0.00361	0	0
ODZ3	55714	broad.mit.edu	37	4	183675600	183675600	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:183675600G>T	uc003ivd.1	+	21	4117	c.4080G>T	c.(4078-4080)CTG>CTT	p.L1360L	ODZ3_uc003ive.1_Silent_p.L773L	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1360	Extracellular (Potential).|NHL 3.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TTTATGTCCTGGATAATAATG	0.438			NA											9	15					1.12685e-05	1.27505e-05	0.004482	1	0
MLF1IP	79682	broad.mit.edu	37	4	185623263	185623263	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:185623263G>A	uc003iwq.2	-	10	974	c.904C>T	c.(904-906)CTG>TTG	p.L302L	MLF1IP_uc003iwp.2_RNA|MLF1IP_uc003iwr.1_Silent_p.L302L	NM_024629	NP_078905	Q71F23	CENPU_HUMAN	MLF1 interacting protein	302	Potential.				CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm					0		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		TTCCTTTTCAGATTTGTCAAC	0.318			NA											7	16					0	0	0.001984	0	0
FAM149A	25854	broad.mit.edu	37	4	187078778	187078778	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:187078778G>A	uc003iyt.3	+	8	1213	c.634G>A	c.(634-636)GTT>ATT	p.V212I	FAM149A_uc011cla.1_Missense_Mutation_p.V212I|FAM149A_uc010isj.2_Missense_Mutation_p.V212I|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Missense_Mutation_p.V212I|FAM149A_uc010isl.2_Missense_Mutation_p.V212I|FAM149A_uc011clb.1_Missense_Mutation_p.V212I	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	503										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		GCACGTCCTCGTTCCACACGC	0.547			NA											14	76					0	0	0.001855	0	0
TRIML2	205860	broad.mit.edu	37	4	189026075	189026075	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:189026075C>G	uc003izl.2	-	2	87	c.51G>C	c.(49-51)CAG>CAC	p.Q17H	TRIML2_uc011cle.1_Missense_Mutation_p.Q67H|TRIML2_uc011clf.1_Missense_Mutation_p.Q67H	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	17	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TCAATATTTCCTGGAATAACT	0.388			NA											22	77					0	0	0.002299	0	0
KIAA0947	23379	broad.mit.edu	37	5	5460982	5460982	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:5460982G>T	uc003jdm.3	+	13	1757	c.1535G>T	c.(1534-1536)AGA>ATA	p.R512I		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	512										ovary(1)|central_nervous_system(1)	2						TGCATTGAGAGATTGTCTGCC	0.448			NA											19	77					5.3912e-06	6.17021e-06	0.006122	1	0
PRDM9	56979	broad.mit.edu	37	5	23527510	23527510	+	Silent	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:23527510A>T	uc003jgo.2	+	11	2495	c.2313A>T	c.(2311-2313)ACA>ACT	p.T771T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	771					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGACACACACAGGGGAGAAGC	0.577			NA								HNSCC(3;0.000094)			22	114					0	0	0.00333	0	0
CDH10	1008	broad.mit.edu	37	5	24487864	24487864	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:24487864C>A	uc003jgr.1	-	12	2607	c.2275G>T	c.(2275-2277)GAC>TAC	p.D759Y	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	759	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAGTTTTGGTCTCCTTCAGTA	0.458			NA								HNSCC(23;0.051)			17	142					1.15088e-07	1.35445e-07	0.004007	1	0
NPR3	4883	broad.mit.edu	37	5	32780843	32780843	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:32780843T>A	uc003jhv.2	+	5	1429	c.1211T>A	c.(1210-1212)GTG>GAG	p.V404E	NPR3_uc010iuo.2_Missense_Mutation_p.V188E|NPR3_uc011cnz.1_Missense_Mutation_p.V188E|NPR3_uc003jhu.2_Missense_Mutation_p.V404E	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	404	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GCCGGGCAGGTGTCCATAGAT	0.512			NA											54	104					0	0	0.00361	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576991	33576991	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:33576991G>A	uc003jia.1	-	19	3303	c.3140C>T	c.(3139-3141)GCA>GTA	p.A1047V	ADAMTS12_uc010iuq.1_Missense_Mutation_p.A962V	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1047	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCTGCTGATTGCTGGAGTGCT	0.552			NA								HNSCC(64;0.19)			4	52					0	0	0.009096	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624341	33624341	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:33624341C>A	uc003jia.1	-	14	2301	c.2138G>T	c.(2137-2139)GGA>GTA	p.G713V	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	713	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ATTACCAGATCCTTCCTTCTG	0.443			NA								HNSCC(64;0.19)			15	84					3.45872e-05	3.84388e-05	0.004007	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33751555	33751556	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:33751555_33751556CC>AA	uc003jia.1	-	3	750_751	c.587_588GG>TT	c.(586-588)AGG>ATT	p.R196I	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R196I|ADAMTS12_uc003jib.1_Missense_Mutation_p.R196I	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	196					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTTTCTGCCTCCTGTAAACGAT	0.465			NA								HNSCC(64;0.19)			21	72					0	0	0.004672	0	0
HCN1	348980	broad.mit.edu	37	5	45262698	45262698	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:45262698C>T	uc003jok.2	-	8	2023	c.1998G>A	c.(1996-1998)CCG>CCA	p.P666P		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	666	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGTGTACACCGGTGGAGATT	0.572			NA											4	49					0	0	0.009096	0	0
PELO	53918	broad.mit.edu	37	5	52096935	52096935	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:52096935A>G	uc003jos.2	+	2	1692	c.707A>G	c.(706-708)AAC>AGC	p.N236S	ITGA1_uc003jov.2_Intron|ITGA1_uc003jou.2_Intron|PELO_uc003jot.1_Intron	NM_015946	NP_057030	Q9BRX2	PELO_HUMAN	pelota homolog	236					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding				0		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				CTCCTGGAAAACCGGTCCAAA	0.453			NA											6	68					0	0	0.001984	0	0
MAP1B	4131	broad.mit.edu	37	5	71495083	71495083	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:71495083C>T	uc003kbw.3	+	5	6142	c.5901C>T	c.(5899-5901)CCC>CCT	p.P1967P	MAP1B_uc010iyw.1_Silent_p.P1984P|MAP1B_uc010iyx.1_Silent_p.P1841P|MAP1B_uc010iyy.1_Silent_p.P1841P	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1967	MAP1B 6.					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CCAGCCCCCCCGAAGTGAGTG	0.478	Melanoma(17;367 822 11631 31730 47712)		NA											17	114					0	0	0.00499	0	0
IQGAP2	10788	broad.mit.edu	37	5	75886333	75886333	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:75886333G>A	uc003kek.2	+	8	963	c.741G>A	c.(739-741)GTG>GTA	p.V247V		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	247					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TAACTTTAGTGGATGACAACC	0.378			NA											28	28					0	0	0.00632	0	0
CMYA5	202333	broad.mit.edu	37	5	79026485	79026485	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:79026485G>T	uc003kgc.2	+	2	1969	c.1897G>T	c.(1897-1899)GAA>TAA	p.E633*		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	633	Glu-rich.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTTGTCAGAAGAAGAGAATGA	0.468			NA											37	40					2.20474e-14	3.06452e-14	0.003755	1	0
VCAN	1462	broad.mit.edu	37	5	82808047	82808047	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:82808047G>A	uc003kii.3	+	6	1230	c.874G>A	c.(874-876)GAC>AAC	p.D292N	VCAN_uc003kij.3_Missense_Mutation_p.D292N|VCAN_uc010jau.2_Missense_Mutation_p.D292N|VCAN_uc003kik.3_Missense_Mutation_p.D292N|VCAN_uc003kih.3_Missense_Mutation_p.D292N	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	292	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAACGGCTTTGACCAGTGCGA	0.597			NA											5	23					0	0	0.000602	0	0
VCAN	1462	broad.mit.edu	37	5	82834788	82834788	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:82834788C>A	uc003kii.3	+	8	6322	c.5966C>A	c.(5965-5967)CCC>CAC	p.P1989H	VCAN_uc003kij.3_Missense_Mutation_p.P1002H|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.P653H	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1989	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCAGAAGGACCCAGTAGCACC	0.512			NA											30	43					6.38683e-12	8.36491e-12	0.008361	1	0
VCAN	1462	broad.mit.edu	37	5	82836357	82836357	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:82836357A>T	uc003kii.3	+	8	7891	c.7535A>T	c.(7534-7536)TAT>TTT	p.Y2512F	VCAN_uc003kij.3_Missense_Mutation_p.Y1525F|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.Y1176F	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2512	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACAGTGTCATATGAGAGGTCC	0.428			NA											11	62					0	0	0.008291	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215287	140215287	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:140215287G>T	uc003lhq.2	+	1	1319	c.1319G>T	c.(1318-1320)AGC>ATC	p.S440I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.S440I	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	440	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACTGCTAGCGTGTCCGTG	0.667	NSCLC(160;258 2013 5070 22440 28951)		NA											73	71					5.22007e-41	8.80005e-41	0.00361	1	0
PCDHA8	56140	broad.mit.edu	37	5	140222376	140222376	+	Silent	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:140222376G>C	uc003lhs.2	+	1	1470	c.1470G>C	c.(1468-1470)GTG>GTC	p.V490V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.V490V	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	490	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGCTGGTGTCCTACTCGC	0.662			NA											58	37					0	0	0.00361	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482425	140482425	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:140482425C>A	uc003lio.2	+	1	2192	c.2192C>A	c.(2191-2193)CCC>CAC	p.P731H	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	731	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCGAGGGCCCCTTTCCAGGG	0.652			NA											66	63					1.04318e-46	1.77661e-46	0.00361	1	0
PCDHB5	26167	broad.mit.edu	37	5	140516563	140516563	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:140516563G>T	uc003liq.2	+	1	1764	c.1547G>T	c.(1546-1548)AGG>ATG	p.R516M		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	516	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGCCCTCAGGTCGCTGGAC	0.701			NA											62	99					5.22007e-41	8.80005e-41	0.00361	1	0
PCDHB9	56127	broad.mit.edu	37	5	140569117	140569117	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:140569117C>T	uc003liw.1	+	3	2226	c.2226C>T	c.(2224-2226)ACC>ACT	p.T742T	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	742	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGCGGCACCGGGACCCTGT	0.652			NA											116	102					0	0	0.00361	0	0
ARSI	340075	broad.mit.edu	37	5	149677827	149677827	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:149677827C>A	uc003lrv.2	-	2	1249	c.660G>T	c.(658-660)CTG>CTT	p.L220L		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	220						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTGGCTGGCCAGGATATGGC	0.632			NA											15	16					3.52763e-06	4.04664e-06	0.00499	1	0
F12	2161	broad.mit.edu	37	5	176830339	176830339	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:176830339G>A	uc003mgo.3	-	12	1496	c.1447C>T	c.(1447-1449)CAG>TAG	p.Q483*	PFN3_uc003mgl.2_5'Flank|F12_uc011dfy.1_Silent_p.F13F|F12_uc003mgn.3_Silent_p.F13F|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	483	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACACCGGCTGAACGTAAGGC	0.706			NA							Hereditary_Angioedema				6	51					0	0	0.001168	0	0
FLT4	2324	broad.mit.edu	37	5	180057745	180057745	+	Silent	SNP	G	G	T	rs142234456		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:180057745G>T	uc003mma.3	-	3	289	c.210C>A	c.(208-210)ACC>ACA	p.T70T	FLT4_uc003mlz.3_Silent_p.T70T|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Silent_p.T70T|FLT4_uc011dgz.1_Silent_p.T70T|FLT4_uc011dha.1_Silent_p.T70T	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	70	Ig-like C2-type 1.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCTTGTCTCCGGTGGCTGGCG	0.677	Colon(97;1075 1466 27033 27547 35871)		NA							Congenital_Hereditary_Lymphedema				24	32					9.86323e-18	1.43911e-17	0.003954	1	0
DUSP22	56940	broad.mit.edu	37	6	311936	311936	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:311936C>A	uc003msx.2	+	3	551	c.112C>A	c.(112-114)CAT>AAT	p.H38N	DUSP22_uc011dhn.1_Missense_Mutation_p.H38N|DUSP22_uc003msy.1_5'UTR	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	38					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TCTGTCTGTCCACGATAGTGC	0.488			NA											5	45					3.59834e-05	3.94631e-05	0.001168	1	0
CAGE1	285782	broad.mit.edu	37	6	7365746	7365746	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:7365746G>T	uc003mxi.2	-	7	2380	c.1659C>A	c.(1657-1659)GCC>GCA	p.A553A	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Silent_p.A471A|CAGE1_uc003mxk.1_Silent_p.A471A	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	689											0	Ovarian(93;0.0418)					TATCCAGTTTGGCTCCCAGAA	0.343			NA											12	22					1.5842e-08	1.90486e-08	0.001855	1	0
GPLD1	2822	broad.mit.edu	37	6	24437453	24437453	+	Silent	SNP	G	G	A	rs139070208		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:24437453G>A	uc003ned.1	-	21	2196	c.2085C>T	c.(2083-2085)TAC>TAT	p.Y695Y		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	695						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						ATGTGAGTGCGTACATGCGAG	0.582			NA											9	69					0	0	0.006214	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158542	26158542	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:26158542G>T	uc003ngr.2	+	1	194	c.145G>T	c.(145-147)GTC>TTC	p.V49F	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.V49F	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	49					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						GCTGAAGCAGGTCCATCCCGA	0.567			NA											24	223					7.01153e-11	8.94822e-11	0.007291	1	0
HIST1H3F	8968	broad.mit.edu	37	6	26250492	26250492	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:26250492G>A	uc003nhg.1	-	1	344	c.342C>T	c.(340-342)CAC>CAT	p.H114H	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	114					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						CTCGCTTGGCGTGGATAGCAC	0.602			NA									OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	99					0	0	0.001855	0	0
BTN2A3	54718	broad.mit.edu	37	6	26431818	26431818	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:26431818A>T	uc011dkl.1	+	6	1766	c.1736A>T	c.(1735-1737)CAG>CTG	p.Q579L	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						GTTGTTCCACAGCTCCCAGCC	0.483			NA											21	80					0	0	0.002299	0	0
C6orf15	29113	broad.mit.edu	37	6	31079656	31079656	+	Silent	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:31079656T>A	uc003nsk.1	-	2	480	c.480A>T	c.(478-480)ACA>ACT	p.T160T	PSORS1C1_uc003nsl.1_5'Flank|PSORS1C1_uc010jsj.1_5'Flank	NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	160											0						GTGAGAGGCCTGTGGCATCGG	0.617			NA											22	27					0	0	0.00278	0	0
SKIV2L	6499	broad.mit.edu	37	6	31928518	31928518	+	Splice_Site	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:31928518G>T	uc003nyn.1	+	6	933	c.544_splice	c.e6+1	p.D182_splice	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_Splice_Site_p.D24_splice|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog							nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TTTGAGAAAGGTAAGGTGGGG	0.423			NA											23	44					1.50039e-11	1.94973e-11	0.001882	1	0
BTNL2	56244	broad.mit.edu	37	6	32362690	32362690	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:32362690C>A	uc003obg.1	-	6	1191	c.1191G>T	c.(1189-1191)ATG>ATT	p.M397I	BTNL2_uc010jty.1_Missense_Mutation_p.M120I|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Missense_Mutation_p.M187I	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	397	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						TCTTTCCTTCCATGTCCCTCC	0.567			NA											71	128					1.59245e-42	2.70283e-42	0.00361	1	0
ITPR3	3710	broad.mit.edu	37	6	33644690	33644690	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:33644690C>G	uc011drk.1	+	26	3647	c.3428C>G	c.(3427-3429)GCC>GGC	p.A1143G		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1143	Cytoplasmic (Potential).			A -> T (in Ref. 2; AAC50064).	activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GAGGCAGGCGCCGCCAAGGAC	0.632			NA											6	29					0	0	0.001168	0	0
DNAH8	1769	broad.mit.edu	37	6	38980313	38980313	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:38980313C>T	uc003ooe.1	+	89	13563	c.12963C>T	c.(12961-12963)TTC>TTT	p.F4321F		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CACTGGGCTTCTGGTTCACTG	0.438			NA											67	116					0	0	0.00361	0	0
FRS3	10817	broad.mit.edu	37	6	41739065	41739065	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:41739065C>A	uc003orc.1	-	7	1015	c.771G>T	c.(769-771)CAG>CAT	p.Q257H		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	257					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GACAGAGGCCCTGGCACTTCA	0.612			NA											22	34					3.8784e-16	5.4825e-16	0.001882	1	0
PTCRA	171558	broad.mit.edu	37	6	42891048	42891049	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:42891048_42891049GG>TT	uc003osx.2	+	2	423_424	c.342_343GG>TT	c.(340-345)GAGGGT>GATTGT	p.114_115EG>DC	PTCRA_uc011duz.1_Missense_Mutation_p.R125I|PTCRA_uc010jxx.1_Missense_Mutation_p.R75I|PTCRA_uc010jxy.2_Missense_Mutation_p.89_90EG>DC|PTCRA_uc010jxz.2_Intron	NM_138296	NP_612153	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha precursor	114_115	Extracellular (Potential).					integral to membrane	receptor activity			ovary(2)	2	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTGGGGCTGAGGGTCACAGCAG	0.619			NA											10	60					0	0	0.004672	0	0
DEFB112	245915	broad.mit.edu	37	6	50011327	50011327	+	Silent	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:50011327T>A	uc011dws.1	-	2	303	c.303A>T	c.(301-303)GTA>GTT	p.V101V		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	101					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					CTTGAGTCCCTACTGAGTCCT	0.413			NA											20	26					0	0	0.010504	0	0
BEND6	221336	broad.mit.edu	37	6	56846716	56846716	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:56846716G>A	uc010kab.2	+	2	694	c.108G>A	c.(106-108)ATG>ATA	p.M36I	BEND6_uc003pdg.2_RNA	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	36											0						ATAGTGACATGGATAAAGGAC	0.348			NA											16	59					0	0	0.00499	0	0
COL12A1	1303	broad.mit.edu	37	6	75818835	75818835	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:75818835A>T	uc003phs.2	-	52	8165	c.7999T>A	c.(7999-8001)TAT>AAT	p.Y2667N	COL12A1_uc003pht.2_Missense_Mutation_p.Y1503N	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2667	TSP N-terminal.|Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						ATAATTTCATAGCAGTCAATG	0.303			NA											22	29					0	0	0.001882	0	0
GABRR2	2570	broad.mit.edu	37	6	89975446	89975446	+	Missense_Mutation	SNP	G	G	T	rs76786334	byFrequency	TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:89975446G>T	uc003pnb.2	-	7	858	c.850C>A	c.(850-852)CGC>AGC	p.R284S	GABRR2_uc011dzx.1_Missense_Mutation_p.R160S	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	284	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		AAGATGTGGCGACGCAACGTG	0.522			NA											13	30					4.36969e-10	5.46485e-10	0.001855	1	0
MCHR2	84539	broad.mit.edu	37	6	100390892	100390892	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:100390892C>A	uc003pqh.1	-	4	835	c.520G>T	c.(520-522)GTC>TTC	p.V174F	MCHR2_uc003pqi.1_Missense_Mutation_p.V174F	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	174	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AATTTGATGACCTTCGAGTAG	0.443			NA											54	57					4.83215e-14	6.66089e-14	0.00361	1	0
PDSS2	57107	broad.mit.edu	37	6	107655415	107655415	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:107655415C>G	uc003prt.2	-	2	708	c.418G>C	c.(418-420)GGG>CGG	p.G140R	PDSS2_uc011eak.1_Missense_Mutation_p.G4R|PDSS2_uc011eal.1_Missense_Mutation_p.G140R|PDSS2_uc003pru.2_Missense_Mutation_p.G140R|PDSS2_uc003prv.2_Missense_Mutation_p.G140R	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	140					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		GAGTAGATCCCACTGACCATG	0.453			NA											11	43					0	0	0.001855	0	0
GPR6	2830	broad.mit.edu	37	6	110301337	110301337	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:110301337G>T	uc011eaw.1	+	2	1202	c.1022G>T	c.(1021-1023)TGG>TTG	p.W341L	GPR6_uc011eav.1_Missense_Mutation_p.W356L|GPR6_uc003ptu.2_Missense_Mutation_p.W341L	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	341	Cytoplasmic (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		CGCGCCCTGTGGCTCCTGCTC	0.602			NA											44	71					1.19451e-25	1.89226e-25	0.00361	1	0
MED23	9439	broad.mit.edu	37	6	131944574	131944574	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:131944574C>A	uc003qcs.1	-	5	487	c.313G>T	c.(313-315)GAC>TAC	p.D105Y	MED23_uc003qcq.2_Missense_Mutation_p.D105Y|MED23_uc003qct.1_Missense_Mutation_p.D105Y|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	105					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TCAAGAGTGTCAGAGTTTATC	0.363			NA											35	40					4.65686e-17	6.69676e-17	0.003755	1	0
TAB2	23118	broad.mit.edu	37	6	149699609	149699609	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:149699609G>T	uc003qmj.2	+	3	736	c.558G>T	c.(556-558)CAG>CAT	p.Q186H	TAB2_uc011eec.1_Missense_Mutation_p.Q154H|TAB2_uc010kia.1_Missense_Mutation_p.Q186H|TAB2_uc010kib.1_Missense_Mutation_p.Q186H|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	186					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						CAAATATCCAGACTGGTCGTA	0.403			NA											30	47					5.77227e-19	8.57251e-19	0.008361	1	0
SYNE1	23345	broad.mit.edu	37	6	152949442	152949442	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:152949442G>T	uc010kiw.2	-	3	627	c.25C>A	c.(25-27)CGG>AGG	p.R9R	SYNE1_uc003qot.3_Silent_p.R9R|SYNE1_uc003qou.3_Silent_p.R9R|SYNE1_uc010kjb.1_Silent_p.R9R|SYNE1_uc003qpa.1_Silent_p.R9R	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	9	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGAGGACACCGGGAGGCCCCT	0.512			NA								HNSCC(10;0.0054)			32	59					4.62619e-21	7.10298e-21	0.004289	1	0
RSPH3	83861	broad.mit.edu	37	6	159420896	159420896	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr6:159420896G>C	uc003qrx.2	-	1	303	c.113C>G	c.(112-114)GCC>GGC	p.A38G	RSPH3_uc010kju.2_Missense_Mutation_p.A38G|RSPH3_uc003qry.1_Missense_Mutation_p.A38G	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	38										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		AAGGACTGCGGCACAAGGGAC	0.697			NA											12	25					0	0	0.001368	0	0
MAD1L1	8379	broad.mit.edu	37	7	1855719	1855719	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:1855719T>C	uc003slh.1	-	19	2410	c.2144A>G	c.(2143-2145)CAG>CGG	p.Q715R	MAD1L1_uc003sle.1_Missense_Mutation_p.Q444R|MAD1L1_uc003slf.1_Missense_Mutation_p.Q715R|MAD1L1_uc003slg.1_Missense_Mutation_p.Q715R|MAD1L1_uc010ksh.1_Missense_Mutation_p.Q715R|MAD1L1_uc003sli.1_Missense_Mutation_p.Q623R|MAD1L1_uc003sld.1_Missense_Mutation_p.Q171R	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	715					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		CGCCACGGTCTGGCGGCTGAA	0.687			NA											9	40					0	0	0.006214	0	0
MAD1L1	8379	broad.mit.edu	37	7	2259031	2259031	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:2259031T>A	uc003slh.1	-	6	798	c.532A>T	c.(532-534)ATG>TTG	p.M178L	MAD1L1_uc003slf.1_Missense_Mutation_p.M178L|MAD1L1_uc003slg.1_Missense_Mutation_p.M178L|MAD1L1_uc010ksh.1_Missense_Mutation_p.M178L|MAD1L1_uc003sli.1_Missense_Mutation_p.M86L|MAD1L1_uc010ksi.1_Missense_Mutation_p.M131L|MAD1L1_uc010ksj.2_Missense_Mutation_p.M178L	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	178	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TTCACCCGCATCTCCTGGTCC	0.627			NA											5	17					0	0	0.001168	0	0
RBAK	57786	broad.mit.edu	37	7	5104718	5104718	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:5104718G>T	uc010kss.1	+	6	1955	c.1631G>T	c.(1630-1632)TGT>TTT	p.C544F	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.C544F	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	544	Interaction with AR.|C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TGTAATGTATGTGGAAAGTTA	0.378			NA											28	70					2.12542e-12	2.81322e-12	0.00632	1	0
TMEM195	392636	broad.mit.edu	37	7	15405839	15405839	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:15405839C>A	uc003stb.1	-	11	1253	c.1083G>T	c.(1081-1083)TCG>TCT	p.S361S		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	361					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						GAGTAACTTGCGACAGTGCCT	0.403			NA											10	18					0.00136819	0.00144953	0.001368	1	0
ITGB8	3696	broad.mit.edu	37	7	20403302	20403302	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:20403302G>T	uc003suu.2	+	2	875	c.170G>T	c.(169-171)AGG>ATG	p.R57M	ITGB8_uc011jyh.1_Translation_Start_Site|ITGB8_uc003sut.2_Missense_Mutation_p.R57M	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	57	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TCCTGTGCCAGGTGCCTTGCG	0.393			NA											17	21					1.2644e-06	1.47431e-06	0.010504	1	0
NT5C3	51251	broad.mit.edu	37	7	33054364	33054364	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:33054364G>T	uc003tdk.2	-	9	1066	c.989C>A	c.(988-990)TCT>TAT	p.S330Y	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.S291Y|NT5C3_uc003tdj.2_Missense_Mutation_p.S291Y	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	330					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			CTGTAAAATAGAGTTGGCTAC	0.358			NA											6	43					0.00307968	0.00319493	0.00308	1	0
GRM3	2913	broad.mit.edu	37	7	86416308	86416308	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:86416308G>T	uc003uid.2	+	3	2299	c.1200G>T	c.(1198-1200)ATG>ATT	p.M400I	GRM3_uc010lef.2_Missense_Mutation_p.M398I|GRM3_uc010leg.2_Missense_Mutation_p.M272I|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	400	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGTATGCCATGGCCCACGCTT	0.527	GBM(52;969 1098 3139 52280)		NA											63	62					6.75472e-32	1.10875e-31	0.00361	1	0
ZAN	7455	broad.mit.edu	37	7	100350269	100350269	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:100350269G>T	uc003uwj.2	+	14	2706	c.2541G>T	c.(2539-2541)ATG>ATT	p.M847I	ZAN_uc003uwk.2_Missense_Mutation_p.M847I|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	847	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCATCCCCATGGAAAAACCCA	0.498			NA											57	65					2.40265e-35	4.00977e-35	0.00361	1	0
RELN	5649	broad.mit.edu	37	7	103191515	103191515	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:103191515C>T	uc003vca.2	-	41	6461	c.6301G>A	c.(6301-6303)GGA>AGA	p.G2101R	RELN_uc010liz.2_Missense_Mutation_p.G2101R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2101					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGTCCTTACCCACAAAGGTGC	0.527	NSCLC(146;835 1944 15585 22231 52158)		NA											12	14					0	0	0.001368	0	0
TFEC	22797	broad.mit.edu	37	7	115580807	115580807	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:115580807G>T	uc003vhj.1	-	8	1026	c.842C>A	c.(841-843)GCC>GAC	p.A281D	TFEC_uc003vhk.1_Missense_Mutation_p.A252D|TFEC_uc003vhl.3_3'UTR|TFEC_uc011kmw.1_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	281	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			ATCAGAAAAGGCTATAGCTTG	0.438			NA											57	141					4.1673e-28	6.68645e-28	0.00361	1	0
DGKI	9162	broad.mit.edu	37	7	137341230	137341230	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:137341230G>A	uc003vtt.2	-	4	664	c.663C>T	c.(661-663)TGC>TGT	p.C221C	DGKI_uc003vtu.2_5'UTR	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	221	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GCTGCTCAATGCAGGCGGTGT	0.438			NA									OREG0018350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	68	68					0	0	0.00361	0	0
C7orf34	135927	broad.mit.edu	37	7	142637441	142637441	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:142637441C>A	uc003wca.2	+	2	252	c.211C>A	c.(211-213)CAG>AAG	p.Q71K		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	46						extracellular region					0	Melanoma(164;0.059)					TGTTCCAGACCAGAATCAAGA	0.532			NA											28	33					4.7796e-09	5.80297e-09	0.004656	1	0
OR2A25	392138	broad.mit.edu	37	7	143771391	143771391	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr7:143771391T>G	uc011ktx.1	+	1	79	c.79T>G	c.(79-81)TTT>GTT	p.F27V		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GATGCTCCTCTTTGGGCTCTT	0.507			NA											6	70					0	0	0.001168	0	0
CSMD1	64478	broad.mit.edu	37	8	3565957	3565957	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:3565957C>A	uc011kwk.1	-	7	1378	c.988G>T	c.(988-990)GGA>TGA	p.G330*		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	330	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTATGGCTTCCATCCTTGCTG	0.453			NA											10	14					0.00829132	0.00856598	0.008291	1	0
RP1L1	94137	broad.mit.edu	37	8	10480667	10480667	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:10480667C>A	uc003wtc.2	-	2	274	c.45G>T	c.(43-45)GAG>GAT	p.E15D		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	15					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCAGGAAGCACTCACGGTGGC	0.647			NA											21	22					4.87955e-14	6.70771e-14	0.005443	1	0
DLC1	10395	broad.mit.edu	37	8	13357463	13357463	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:13357463A>T	uc003wwm.2	-	2	562	c.118T>A	c.(118-120)TTG>ATG	p.L40M	DLC1_uc003wwn.2_Missense_Mutation_p.L40M|DLC1_uc011kxy.1_Missense_Mutation_p.L40M	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	40					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CTTGCCTGCAAGCTGTCAGCT	0.448			NA											36	62					0	0	0.003755	0	0
NPM2	10361	broad.mit.edu	37	8	21890716	21890716	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:21890716A>T	uc003xab.2	+	5	1004	c.346A>T	c.(346-348)AGT>TGT	p.S116C	NPM2_uc003xac.2_Missense_Mutation_p.S116C|NPM2_uc003xad.2_Missense_Mutation_p.S116C|NPM2_uc003xae.2_Missense_Mutation_p.S116C|NPM2_uc003xaf.2_Missense_Mutation_p.S116C	NM_182795	NP_877724	Q86SE8	NPM2_HUMAN	nucleoplasmin 2	116					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		CGTGTTCCTCAGTGGCCAGGA	0.577			NA											16	27					0	0	0.006122	0	0
HR	55806	broad.mit.edu	37	8	21978725	21978725	+	Silent	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:21978725A>T	uc003xas.2	-	10	2885	c.2220T>A	c.(2218-2220)GCT>GCA	p.A740A	HR_uc003xat.2_Silent_p.A740A	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	740							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CTGGGGTCTCAGCGGAATCGG	0.642			NA											42	47					0	0	0.00874	0	0
STAR	6770	broad.mit.edu	37	8	38006204	38006204	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:38006204G>T	uc003xkv.1	-	2	397	c.133C>A	c.(133-135)CCT>ACT	p.P45T	STAR_uc010lwc.1_Intron	NM_001007243	NP_001007244	P49675	STAR_HUMAN	steroidogenic acute regulatory protein isoform	45					C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		CACGTGCTAGGGGTGGGGCCC	0.617			NA											16	56					1.33834e-09	1.64896e-09	0.007413	1	0
SNTG1	54212	broad.mit.edu	37	8	51314833	51314833	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:51314833C>A	uc010lxy.1	+	5	462	c.91C>A	c.(91-93)CTA>ATA	p.L31I	SNTG1_uc003xqs.1_Missense_Mutation_p.L31I|SNTG1_uc010lxz.1_Missense_Mutation_p.L31I|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	31					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCGGCTGCACCTAGCCAAAGA	0.388			NA											30	61					1.88708e-17	2.72943e-17	0.008361	1	0
TCEA1	6917	broad.mit.edu	37	8	54906316	54906316	+	Splice_Site	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:54906316C>T	uc003xru.2	-	4	556	c.233_splice	c.e4-1	p.D78_splice	TCEA1_uc003xrv.2_Splice_Site_p.D57_splice|TCEA1_uc011ldw.1_Intron|TCEA1_uc003xrw.1_Splice_Site	NM_006756	NP_006747	P23193	TCEA1_HUMAN	transcription elongation factor A 1 isoform 1						positive regulation of viral transcription|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|translation elongation factor activity|zinc ion binding				0		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;9.1e-07)|Epithelial(17;9.44e-05)|all cancers(17;0.000699)			GATGGCCCATCTGAAAATTAT	0.368			NA	T	PLAG1	salivary adenoma								32	75					0	0	0.003755	0	0
C8orf34	116328	broad.mit.edu	37	8	69445345	69445345	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:69445345G>A	uc010lyz.2	+	7	857	c.808G>A	c.(808-810)GAA>AAA	p.E270K	C8orf34_uc010lyy.1_Missense_Mutation_p.E270K|C8orf34_uc003xyb.2_Missense_Mutation_p.E245K	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	270					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TGTAACAGAAGAAGATATTGA	0.358			NA											8	120					0	0	0.004482	0	0
XKR9	389668	broad.mit.edu	37	8	71619241	71619241	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:71619241G>T	uc003xyq.2	+	4	880	c.346G>T	c.(346-348)GAA>TAA	p.E116*	XKR9_uc010lze.2_Nonsense_Mutation_p.E116*|XKR9_uc010lzd.2_5'UTR	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	116						integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			CTTCGTGGAAGAACAAATTGA	0.358			NA											36	44					7.11191e-15	9.96866e-15	0.002836	1	0
KCNB2	9312	broad.mit.edu	37	8	73848718	73848718	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:73848718C>A	uc003xzb.2	+	3	1716	c.1128C>A	c.(1126-1128)ACC>ACA	p.T376T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	376					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGTGGGCCACCATCACCATGA	0.448			NA											51	109					8.94452e-30	1.44913e-29	0.00361	1	0
KCNB2	9312	broad.mit.edu	37	8	73849039	73849039	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:73849039C>T	uc003xzb.2	+	3	2037	c.1449C>T	c.(1447-1449)GAC>GAT	p.D483D		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	483	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACTCCGCCGACGATAATCACC	0.512			NA											47	107					0	0	0.00361	0	0
KIAA1429	25962	broad.mit.edu	37	8	95541541	95541541	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:95541541G>A	uc003ygo.1	-	7	650	c.637C>T	c.(637-639)CAT>TAT	p.H213Y	KIAA1429_uc003ygp.2_Missense_Mutation_p.H213Y|KIAA1429_uc010maz.1_5'Flank	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	213	Glu-rich.				mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCTTCTCTATGAGGAGCATCC	0.343			NA											3	44					0	0	0.004672	0	0
TM7SF4	81501	broad.mit.edu	37	8	105367256	105367256	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:105367256C>G	uc003ylx.1	+	3	1230	c.1181C>G	c.(1180-1182)TCC>TGC	p.S394C		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	394	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGACTGTTGTCCTCTATCCTT	0.423			NA											20	62					0	0	0.010504	0	0
CSMD3	114788	broad.mit.edu	37	8	113301716	113301716	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:113301716T>A	uc003ynu.2	-	57	9185	c.9026A>T	c.(9025-9027)GAG>GTG	p.E3009V	CSMD3_uc003yns.2_Missense_Mutation_p.E2211V|CSMD3_uc003ynt.2_Missense_Mutation_p.E2969V|CSMD3_uc011lhx.1_Missense_Mutation_p.E2840V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3009	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTATACTTCTCGCCAGACAG	0.408			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	46					0	0	0.00333	0	0
FAM135B	51059	broad.mit.edu	37	8	139145008	139145008	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:139145008A>T	uc003yuy.2	-	20	4220	c.4049T>A	c.(4048-4050)CTG>CAG	p.L1350Q	FAM135B_uc003yux.2_Missense_Mutation_p.L1251Q|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1350										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGAGGGCCCAGGAGGTTGTT	0.527			NA								HNSCC(54;0.14)			59	164					0	0	0.00361	0	0
FAM135B	51059	broad.mit.edu	37	8	139164809	139164809	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:139164809G>T	uc003yuy.2	-	13	2080	c.1909C>A	c.(1909-1911)CCC>ACC	p.P637T	FAM135B_uc003yux.2_Missense_Mutation_p.P538T|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.P199T|FAM135B_uc003yvb.2_Missense_Mutation_p.P199T	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	637										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCTCAGAGGGGGTGAGTTTC	0.473			NA								HNSCC(54;0.14)			25	60					1.66031e-10	2.09745e-10	0.003954	1	0
COL22A1	169044	broad.mit.edu	37	8	139706771	139706771	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr8:139706771G>T	uc003yvd.2	-	34	3127	c.2680C>A	c.(2680-2682)CAG>AAG	p.Q894K	COL22A1_uc011ljo.1_Missense_Mutation_p.Q194K	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	894	Pro-rich.|Gly-rich.|Collagen-like 7.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GTGGGTCCCTGAGGCCCCAAT	0.612			NA								HNSCC(7;0.00092)			9	69					2.80697e-09	3.44147e-09	0.000978	1	0
GLDC	2731	broad.mit.edu	37	9	6610267	6610267	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:6610267G>A	uc003zkc.2	-	4	753	c.560C>T	c.(559-561)ACA>ATA	p.T187I		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	187					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GTCCAGGCCTGTGATGTCACA	0.512			NA											9	8					0	0	0.004482	0	0
FRMPD1	22844	broad.mit.edu	37	9	37732369	37732369	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:37732369G>T	uc004aag.1	+	10	971	c.927G>T	c.(925-927)GCG>GCT	p.A309A	FRMPD1_uc004aah.1_Silent_p.A309A|FRMPD1_uc011lqm.1_Silent_p.A131A|FRMPD1_uc011lqn.1_Silent_p.A178A	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	309	FERM.					cytoskeleton|cytosol|plasma membrane		p.A309P(1)		ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TCCGACTCGCGGCTCTGCACA	0.507			NA											20	43					3.51602e-12	4.61708e-12	0.008871	1	0
FRMPD1	22844	broad.mit.edu	37	9	37740320	37740320	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:37740320G>A	uc004aag.1	+	15	1839	c.1795G>A	c.(1795-1797)GGC>AGC	p.G599S	FRMPD1_uc004aah.1_Missense_Mutation_p.G599S|FRMPD1_uc011lqm.1_Missense_Mutation_p.G421S|FRMPD1_uc011lqn.1_Missense_Mutation_p.G468S	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	599						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TGAGAGCCGCGGCTACAGGAC	0.632			NA											4	55					0	0	0.009096	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323771	79323771	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:79323771T>C	uc010mpk.2	-	8	3543	c.3419A>G	c.(3418-3420)GAC>GGC	p.D1140G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1140					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CCCACTGCAGTCATCCCAGTC	0.517			NA											27	95					0	0	0.007291	0	0
FLJ46321	389763	broad.mit.edu	37	9	84606718	84606718	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:84606718A>T	uc004amn.2	+	4	1380	c.1333A>T	c.(1333-1335)AAC>TAC	p.N445Y		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	445						integral to membrane					0						ACTTAGGCCAAACTACCAACT	0.413			NA											7	69					0	0	0.004482	0	0
FRMD3	257019	broad.mit.edu	37	9	85950556	85950556	+	Splice_Site	SNP	T	T	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:85950556T>A	uc004ams.1	-	6	675	c.473_splice	c.e6-1	p.A158_splice	FRMD3_uc004amr.1_Splice_Site_p.A144_splice	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3							cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						CAAGCTCAGCTGTAATGAGTG	0.413			NA											3	13					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	9	90745720	90745720	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:90745720G>T	uc011lti.1	-	4	2261	c.2232C>A	c.(2230-2232)GCC>GCA	p.A744A	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;												NA						TCCCTCGCGGGGCCCTCTGGA	0.562			NA											5	60					0.00116845	0.00124054	0.001168	1	0
INVS	27130	broad.mit.edu	37	9	103046619	103046619	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:103046619A>T	uc004bap.1	+	13	2014	c.1802A>T	c.(1801-1803)AAC>ATC	p.N601I	INVS_uc011lve.1_Missense_Mutation_p.N505I|INVS_uc004bao.1_Missense_Mutation_p.N601I|INVS_uc004baq.1_Missense_Mutation_p.N505I|INVS_uc004bar.1_Missense_Mutation_p.N505I|INVS_uc010mtb.1_Missense_Mutation_p.N275I	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	601					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				GAGGAAGAAAACAAACGAAAA	0.468			NA											32	40					0	0	0.002836	0	0
PAPPA	5069	broad.mit.edu	37	9	119124912	119124912	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:119124912C>T	uc004bjn.2	+	18	4770	c.4389C>T	c.(4387-4389)ACC>ACT	p.T1463T	PAPPA_uc011lxq.1_Silent_p.T838T	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1463	Sushi 4.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGATGGCACCTGGAACGGCT	0.522			NA											6	72					0	0	0.001984	0	0
PTGS1	5742	broad.mit.edu	37	9	125154739	125154739	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:125154739G>T	uc004bmg.1	+	11	1851	c.1716G>T	c.(1714-1716)AAG>AAT	p.K572N	PTGS1_uc011lys.1_Missense_Mutation_p.K510N|PTGS1_uc010mwb.1_Missense_Mutation_p.K426N|PTGS1_uc004bmf.1_Missense_Mutation_p.K535N|PTGS1_uc004bmh.1_Missense_Mutation_p.K463N|PTGS1_uc011lyt.1_Missense_Mutation_p.K463N	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	572					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TCAACACCAAGACCTGTCCCT	0.582			NA											43	42					6.2361e-21	9.51626e-21	0.007835	1	0
C9orf171	389799	broad.mit.edu	37	9	135374887	135374887	+	Missense_Mutation	SNP	C	C	A	rs143736165		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:135374887C>A	uc004cbn.2	+	4	580	c.532C>A	c.(532-534)CGT>AGT	p.R178S	C9orf171_uc004cbo.2_Missense_Mutation_p.R142S	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	178										ovary(4)|large_intestine(1)	5						CTTGCTCTACCGTCAGCTCAA	0.612			NA											50	68					1.54886e-18	2.28663e-18	0.00361	1	0
DBH	1621	broad.mit.edu	37	9	136521703	136521703	+	Missense_Mutation	SNP	C	C	A	rs78512658		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:136521703C>A	uc004cel.2	+	10	1502	c.1493C>A	c.(1492-1494)ACG>AAG	p.T498K	uc010nao.1_Intron	NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	498	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TACCCCCAGACGCAGCTGGAG	0.632			NA											5	50					3.59834e-05	3.94631e-05	0.001168	1	0
CACNA1B	774	broad.mit.edu	37	9	140938287	140938287	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:140938287G>A	uc004cog.2	+	21	3493	c.3348G>A	c.(3346-3348)GTG>GTA	p.V1116V	CACNA1B_uc011mfd.1_Silent_p.V646V|CACNA1B_uc004coi.2_Silent_p.V326V	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1116	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGGATGACGTGATGAGGAGCG	0.602			NA											21	142					0	0	0.001882	0	0
FAM47B	170062	broad.mit.edu	37	X	34962320	34962320	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:34962320C>A	uc004ddi.1	+	1	1390	c.1372C>A	c.(1372-1374)CAC>AAC	p.H458N		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	458										ovary(3)|breast(1)	4						TCAACGTAGACACACATCGAG	0.483			NA											26	36					2.79863e-10	3.52656e-10	0.004656	1	0
CYBB	1536	broad.mit.edu	37	X	37653054	37653054	+	Silent	SNP	G	G	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:37653054G>A	uc004ddr.2	+	5	535	c.474G>A	c.(472-474)AAG>AAA	p.K158K	CYBB_uc011mke.1_Intron|CYBB_uc011mkf.1_Silent_p.K126K|CYBB_uc011mkg.1_Intron	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	158	Extracellular (Potential).|Ferric oxidoreductase.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TTGCTCGAAAGAGAATAAAGG	0.393			NA											15	15					0	0	0.00499	0	0
CCNB3	85417	broad.mit.edu	37	X	50054016	50054016	+	Silent	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:50054016A>G	uc004dox.3	+	6	3145	c.2847A>G	c.(2845-2847)TTA>TTG	p.L949L	CCNB3_uc004doy.2_Silent_p.L949L|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	949					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					AGGAGCCATTAGCCTTACAAG	0.483			NA											3	49					0	0	0.004672	0	0
HEPH	9843	broad.mit.edu	37	X	65423229	65423229	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:65423229G>T	uc011moz.1	+	13	2170	c.2110G>T	c.(2110-2112)GCA>TCA	p.A704S	HEPH_uc004dwn.2_Missense_Mutation_p.A704S|HEPH_uc004dwo.2_Missense_Mutation_p.A434S|HEPH_uc010nkr.2_Missense_Mutation_p.A512S|HEPH_uc011mpa.1_Missense_Mutation_p.A704S|HEPH_uc010nks.2_5'UTR	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	701	Plastocyanin-like 4.|Extracellular (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TTATTGCCAGGCAGGCAGCCA	0.532			NA											14	9					8.60227e-14	1.17927e-13	0.004007	1	0
OGT	8473	broad.mit.edu	37	X	70783045	70783045	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:70783045C>T	uc004eaa.1	+	17	2431	c.2214C>T	c.(2212-2214)GGC>GGT	p.G738G	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.G728G|OGT_uc004eac.2_Silent_p.G599G|OGT_uc004ead.2_Silent_p.G357G	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	738					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TTCTGAATGGCATCGACCTCA	0.353			NA											29	39					0	0	0.00632	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106083313	106083313	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:106083313A>G	uc004emo.2	+	9	1554	c.1389A>G	c.(1387-1389)ATA>ATG	p.I463M	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Missense_Mutation_p.I463M	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	463						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CATGGAAAATACTGTTTGCAG	0.333			NA											45	20					0	0	0.003214	0	0
IRS4	8471	broad.mit.edu	37	X	107978467	107978467	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:107978467C>A	uc004eoc.2	-	1	1141	c.1108G>T	c.(1108-1110)GGC>TGC	p.G370C		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	370						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTGAGCCAGCCTCCCGGCTCG	0.642			NA											98	36					2.24395e-52	3.8347e-52	0.00361	1	0
HTR2C	3358	broad.mit.edu	37	X	114082672	114082672	+	Silent	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:114082672G>T	uc004epu.1	+	5	1184	c.456G>T	c.(454-456)CGG>CGT	p.R152R	HTR2C_uc010nqc.1_Silent_p.R152R|HTR2C_uc004epv.1_Splice_Site_p.R152_splice	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	152	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CGCTGGATCGGTATGTAGCAA	0.423			NA											55	19					5.57489e-27	8.88777e-27	0.00361	1	0
XPNPEP2	7512	broad.mit.edu	37	X	128887222	128887222	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:128887222C>T	uc004eut.1	+	11	1349	c.1105C>T	c.(1105-1107)CAC>TAC	p.H369Y		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	369					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CAAGGCCAGCCACGTAAGTCC	0.537			NA											56	22					0	0	0.00361	0	0
USP26	83844	broad.mit.edu	37	X	132160222	132160223	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:132160222_132160223GG>TT	uc010nrm.1	-	6	2496_2497	c.2026_2027CC>AA	c.(2026-2028)CCT>AAT	p.P676N	USP26_uc011mvf.1_Missense_Mutation_p.P676N	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	676					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GCTGCTGGCAGGTTTACCTCCA	0.431	NSCLC(104;342 1621 36940 47097 52632)		NA											47	18					0	0	0.004672	0	0
F9	2158	broad.mit.edu	37	X	138633376	138633376	+	Silent	SNP	C	C	A	rs137852240		TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:138633376C>A	uc004fas.1	+	6	705	c.676C>A	c.(676-678)CGG>AGG	p.R226R	F9_uc004fat.1_Silent_p.R188R	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	226		Cleavage; by factor XIa.	R -> G (in HEMB; severe; Madrid).|R -> Q (in HEMB; severe; Hilo and Novara).|R -> W (in HEMB; severe; Nagoya-1, Dernbach, Deventer, Idaho, etc.).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGACTTCACTCGGGTTGTTGG	0.433			NA											40	20					6.2361e-21	9.51626e-21	0.007835	1	0
MAGEC3	139081	broad.mit.edu	37	X	140984971	140984971	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:140984971C>A	uc011mwp.1	+	7	1427	c.1427C>A	c.(1426-1428)CCT>CAT	p.P476H	MAGEC3_uc004fbs.2_Missense_Mutation_p.P178H|MAGEC3_uc010nsj.2_Missense_Mutation_p.P178H	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	476	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACAAAAGAGCCTGTCACAAAG	0.443			NA											53	33					2.47907e-22	3.85375e-22	0.00361	1	0
SPANXN1	494118	broad.mit.edu	37	X	144329156	144329156	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:144329156G>T	uc004fcb.2	+	1	50	c.50G>T	c.(49-51)TGT>TTT	p.C17F		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	17											0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGCCCCTGTGAATCCAAC	0.294			NA											76	47					4.49761e-31	7.33435e-31	0.00361	1	0
SLITRK2	84631	broad.mit.edu	37	X	144905599	144905599	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:144905599C>T	uc004fcd.2	+	5	2646	c.1656C>T	c.(1654-1656)ATC>ATT	p.I552I	SLITRK2_uc010nsp.2_Silent_p.I552I|SLITRK2_uc010nso.2_Silent_p.I552I|SLITRK2_uc011mwq.1_Silent_p.I552I|SLITRK2_uc011mwr.1_Silent_p.I552I|SLITRK2_uc011mws.1_Silent_p.I552I|SLITRK2_uc004fcg.2_Silent_p.I552I|SLITRK2_uc011mwt.1_Silent_p.I552I	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	552	Extracellular (Potential).|LRRCT 2.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCCCTGTCATCATTAATGAGG	0.502			NA											14	31					0	0	0.00245	0	0
FMR1NB	158521	broad.mit.edu	37	X	147062998	147062998	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:147062998C>A	uc004fcm.2	+	1	150	c.76C>A	c.(76-78)CTG>ATG	p.L26M		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	26	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCACTTAGAGCTGGCAACTTA	0.597			NA											36	18					2.47316e-13	3.35355e-13	0.003271	1	0
GABRQ	55879	broad.mit.edu	37	X	151817739	151817739	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:151817739C>A	uc004ffp.1	+	5	573	c.553C>A	c.(553-555)CTG>ATG	p.L185M		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	185	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGCTTGTTCCCTGGATCTGCA	0.507			NA											46	23					2.52991e-16	3.59665e-16	0.00361	1	0
PNMA5	114824	broad.mit.edu	37	X	152159632	152159632	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:152159632C>A	uc010ntw.2	-	3	850	c.511G>T	c.(511-513)GGC>TGC	p.G171C	PNMA5_uc004fha.3_Missense_Mutation_p.G171C|PNMA5_uc010ntx.2_Missense_Mutation_p.G171C|PNMA5_uc004fgy.3_Missense_Mutation_p.G171C	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	171					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GTCTCTTCGCCTGGGCTAGGG	0.517			NA											72	23					3.07281e-33	5.07727e-33	0.00361	1	0
PLXNB3	5365	broad.mit.edu	37	X	153036815	153036815	+	Silent	SNP	C	C	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:153036815C>A	uc004fii.2	+	13	2478	c.2304C>A	c.(2302-2304)ACC>ACA	p.T768T	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Silent_p.T450T|PLXNB3_uc010nuk.2_Silent_p.T791T|PLXNB3_uc011mzd.1_Silent_p.T407T	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	768	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTACGTCACCCAGGGTGAAG	0.647			NA											37	15					5.43694e-19	8.0986e-19	0.005524	1	0
SPRY3	10251	broad.mit.edu	37	X	155004046	155004046	+	Silent	SNP	C	C	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:155004046C>T	uc004fnq.1	+	2	967	c.513C>T	c.(511-513)AAC>AAT	p.N171N	SPRY3_uc010nvl.1_Intron	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	171	SPR.|Cys-rich.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGCTGTGCAACCAGCGCTGCC	0.587			NA											12	148					0	0	0.001855	0	0
HTR6	3362	broad.mit.edu	37	1	20005550	20005550	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:20005550delC	uc001bcl.2	+	3	1479	c.1012delC	c.(1012-1014)CCAfs	p.P338fs		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	338	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CCTGCCATGTCCACGCTGTCC	0.657	Esophageal Squamous(168;1879 2619 6848 21062)		NA											18	52	---	---	---	---	NA	NA	NA	NA	NA
C8A	731	broad.mit.edu	37	1	57372406	57372406	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr1:57372406delT	uc001cyo.2	+	8	1295	c.1163delT	c.(1162-1164)ATAfs	p.I388fs		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	388	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGACAAAATAAATGTTGGT	0.413			NA											39	145	---	---	---	---	NA	NA	NA	NA	NA
C14orf145	145508	broad.mit.edu	37	14	81297530	81297531	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr14:81297530_81297531insA	uc001xux.2	-	12	1336_1337	c.1165_1166insT	c.(1165-1167)GAGfs	p.E389fs	C14orf145_uc010asz.1_RNA|C14orf145_uc001xuz.2_Frame_Shift_Ins_p.E389fs|C14orf145_uc001xuy.1_Frame_Shift_Ins_p.E247fs	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	389	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		GTCTTTTCTCTCCATGCACCGT	0.406			NA											38	68	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578475	7578475	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:7578475delG	uc002gim.2	-	5	649	c.455delC	c.(454-456)CCGfs	p.P152fs	TP53_uc002gig.1_Frame_Shift_Del_p.P152fs|TP53_uc002gih.2_Frame_Shift_Del_p.P152fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.P20fs|TP53_uc010cng.1_Frame_Shift_Del_p.P20fs|TP53_uc002gii.1_Frame_Shift_Del_p.P20fs|TP53_uc010cnh.1_Frame_Shift_Del_p.P152fs|TP53_uc010cni.1_Frame_Shift_Del_p.P152fs|TP53_uc002gij.2_Frame_Shift_Del_p.P152fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.P59fs|TP53_uc002gio.2_Frame_Shift_Del_p.P20fs|TP53_uc010vug.1_Frame_Shift_Del_p.P113fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	152	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(57)|p.P152S(21)|p.P152fs*18(17)|p.P152T(7)|p.0?(7)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P153fs*28(4)|p.P152fs*14(4)|p.P152fs*28(3)|p.P152R(3)|p.T150fs*16(3)|p.P152A(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152_P153insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGCCGGGCGGGGGTGTGGA	0.612	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	33	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29667523	29667527	+	Frame_Shift_Del	DEL	GACTC	GACTC	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	GACTC	GACTC	-	-	GACTC	GACTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr17:29667523_29667527delGACTC	uc002hgg.2	+	47	7255_7259	c.6922_6926delGACTC	c.(6922-6927)GACTCGfs	p.D2308fs	NF1_uc002hgh.2_Frame_Shift_Del_p.D2287fs|NF1_uc010cso.2_Frame_Shift_Del_p.D496fs|NF1_uc010wbt.1_5'UTR|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2308_2309					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.D2308fs*11(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCTTTGCCAGGACTCGCCTCTGCAC	0.429			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			27	32	---	---	---	---	NA	NA	NA	NA	NA
MBD1	4152	broad.mit.edu	37	18	47803337	47803337	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr18:47803337delC	uc010dow.1	-	4	694	c.257delG	c.(256-258)CGAfs	p.R86fs	MBD1_uc002lef.2_5'UTR|MBD1_uc002leg.2_Frame_Shift_Del_p.R86fs|MBD1_uc010xdi.1_Frame_Shift_Del_p.R112fs|MBD1_uc002leh.3_Frame_Shift_Del_p.R86fs|MBD1_uc002len.2_Frame_Shift_Del_p.R86fs|MBD1_uc002lei.3_Frame_Shift_Del_p.R86fs|MBD1_uc002lej.3_Frame_Shift_Del_p.R86fs|MBD1_uc002lek.3_Frame_Shift_Del_p.R86fs|MBD1_uc002lel.3_Frame_Shift_Del_p.R86fs|MBD1_uc002lem.3_Frame_Shift_Del_p.R86fs|MBD1_uc010xdj.1_Frame_Shift_Del_p.R86fs|MBD1_uc010xdk.1_Frame_Shift_Del_p.R86fs|MBD1_uc010dox.1_Frame_Shift_Del_p.R86fs|MBD1_uc002leo.2_Frame_Shift_Del_p.R86fs	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	86	Nuclear localization signal (Potential).				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGGCTTCTTTCGCTTCTTGCT	0.587			NA											52	85	---	---	---	---	NA	NA	NA	NA	NA
BAZ2B	29994	broad.mit.edu	37	2	160289857	160289857	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr2:160289857delT	uc002uao.2	-	9	1663	c.1311delA	c.(1309-1311)GCAfs	p.A437fs	BAZ2B_uc002uap.2_Frame_Shift_Del_p.A435fs|BAZ2B_uc002uas.1_Frame_Shift_Del_p.A374fs|BAZ2B_uc002uaq.1_Frame_Shift_Del_p.A365fs|BAZ2B_uc002uar.1_Frame_Shift_Del_p.A10fs	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GTGATGGGAATGCCTGTTTAT	0.348			NA											33	59	---	---	---	---	NA	NA	NA	NA	NA
C20orf46	55321	broad.mit.edu	37	20	1161830	1161830	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr20:1161830delG	uc010gaa.1	-	3	652	c.433delC	c.(433-435)CGTfs	p.R145fs	C20orf46_uc002weq.1_Frame_Shift_Del_p.R145fs	NM_018354	NP_060824	Q9NUR3	CT046_HUMAN	hypothetical protein LOC55321	145						integral to membrane	protein binding			ovary(1)	1						CGAGCCTCACGGGGGATGGCG	0.602			NA											37	27	---	---	---	---	NA	NA	NA	NA	NA
ARHGAP31	57514	broad.mit.edu	37	3	119109712	119109713	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr3:119109712_119109713insC	uc003ecj.3	+	7	1295_1296	c.763_764insC	c.(763-765)GCCfs	p.A255fs		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	255					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GGAAGCTCAAGCCCGCAGCCTG	0.579	Pancreas(7;176 297 5394 51128 51241)		NA											15	54	---	---	---	---	NA	NA	NA	NA	NA
LRBA	987	broad.mit.edu	37	4	151412167	151412167	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr4:151412167delC	uc010ipj.2	-	42	6858	c.6384delG	c.(6382-6384)GGGfs	p.G2128fs	LRBA_uc003ils.3_Frame_Shift_Del_p.G18fs|LRBA_uc003ilt.3_Frame_Shift_Del_p.G776fs|LRBA_uc003ilu.3_Frame_Shift_Del_p.G2117fs	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2128						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTCCATGCAGCCCTTCTGTAT	0.358			NA											17	94	---	---	---	---	NA	NA	NA	NA	NA
VCAN	1462	broad.mit.edu	37	5	82837339	82837340	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr5:82837339_82837340delAC	uc003kii.3	+	8	8873_8874	c.8517_8518delAC	c.(8515-8520)GGACACfs	p.G2839fs	VCAN_uc003kij.3_Frame_Shift_Del_p.G1852fs|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Frame_Shift_Del_p.G1503fs	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2839_2840	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAGCCTCTGGACACACAGAGAT	0.45			NA											8	107	---	---	---	---	NA	NA	NA	NA	NA
UNC13B	10497	broad.mit.edu	37	9	35237720	35237721	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chr9:35237720_35237721delCA	uc003zwq.2	+	5	583_584	c.291_292delCA	c.(289-294)TCCACAfs	p.S97fs	UNC13B_uc010mkl.1_Frame_Shift_Del_p.S97fs|UNC13B_uc003zwr.2_Frame_Shift_Del_p.S97fs	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	97_98					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGGAATGGTCCACATTAGAGGC	0.391			NA											20	61	---	---	---	---	NA	NA	NA	NA	NA
ZNF645	158506	broad.mit.edu	37	X	22291122	22291123	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:22291122_22291123insT	uc004dai.1	+	1	63_64	c.14_15insT	c.(13-15)CCTfs	p.P5fs		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	5						intracellular	zinc ion binding			lung(1)|pancreas(1)	2						AACAAGATGCCTGCTGGTGAAC	0.376			NA											28	11	---	---	---	---	NA	NA	NA	NA	NA
NLGN3	54413	broad.mit.edu	37	X	70389735	70389735	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:70389735delC	uc004dzb.2	+	7	2579	c.2275delC	c.(2275-2277)CCCfs	p.P759fs	NLGN3_uc004dzc.2_Frame_Shift_Del_p.P642fs|NLGN3_uc011mps.1_Frame_Shift_Del_p.P739fs|NLGN3_uc004dze.2_Frame_Shift_Del_p.P577fs	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	779	Cytoplasmic (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					TGAGGCCGGTCCCCCCCATGA	0.677	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
BCORL1	63035	broad.mit.edu	37	X	129147055	129147055	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7542-01A-21D-2063-08	TCGA-78-7542-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2dfbb519-695a-4b2b-8a65-0d98d8f5b76b	607858d0-6112-4240-8757-4212347fd874	g.chrX:129147055delG	uc004evb.1	+	4	421	c.307delG	c.(307-309)GGGfs	p.G103fs	BCORL1_uc010nrd.1_Frame_Shift_Del_p.G5fs	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	103					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GGACTACGCTGGGAACGTGGC	0.607			NA											39	26	---	---	---	---	NA	NA	NA	NA	NA
