Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11273609	11273609	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:11273609C>T	uc001asd.2	-	21	3253	c.3132G>A	c.(3130-3132)ATG>ATA	p.M1044I		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1044					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TTGAGGTGTTCATGACCCAGA	0.448			NA											23	99					0	0	0.005443	0	0
UBR4	23352	broad.mit.edu	37	1	19423145	19423145	+	Splice_Site	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:19423145C>G	uc001bbi.2	-	92	13395	c.13391_splice	c.e92-1	p.D4464_splice	UBR4_uc010ocv.1_Splice_Site_p.D27_splice|UBR4_uc009vph.2_Splice_Site_p.D98_splice|UBR4_uc010ocw.1_Splice_Site_p.D128_splice|UBR4_uc001bbg.2_Splice_Site_p.D175_splice|UBR4_uc001bbh.2_Splice_Site_p.D173_splice	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		tcttcttcatctAGGGGAGAA	0.448			NA											26	121					0	0	0.003954	0	0
STMN1	3925	broad.mit.edu	37	1	26228095	26228095	+	Nonsense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:26228095C>A	uc001bkz.2	-	4	629	c.265G>T	c.(265-267)GAG>TAG	p.E89*	STMN1_uc010oev.1_Nonsense_Mutation_p.E89*|STMN1_uc001bla.2_Nonsense_Mutation_p.E89*|STMN1_uc001blb.2_Nonsense_Mutation_p.E82*|STMN1_uc001blc.2_Nonsense_Mutation_p.E89*	NM_203401	NP_981946	P16949	STMN1_HUMAN	stathmin 1 isoform a	89	Potential.				cell differentiation|intracellular signal transduction|microtubule depolymerization|mitotic spindle organization|nervous system development|response to virus	cytoplasm|microtubule	signal transducer activity|tubulin binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000163)|all_lung(284;0.000234)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.013)|READ - Rectum adenocarcinoma(331;0.0649)		TTGTTGTTCTCTTCTATTGCC	0.438			NA											25	57					3.7963e-18	8.44892e-18	0.00333	1	0
LCK	3932	broad.mit.edu	37	1	32751144	32751144	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:32751144C>G	uc001bux.2	+	13	1495	c.1357C>G	c.(1357-1359)CTG>GTG	p.L453V	LCK_uc001buy.2_Missense_Mutation_p.L453V|LCK_uc001buz.2_Missense_Mutation_p.L483V|LCK_uc001bva.2_Missense_Mutation_p.L460V	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	453	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GATTCAGAACCTGGAGCGAGG	0.552			NA	T	TRB@	T-ALL								27	38					0	0	0.007291	0	0
GJA9	81025	broad.mit.edu	37	1	39340775	39340775	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:39340775C>A	uc001cct.1	-	2	1277	c.996G>T	c.(994-996)GAG>GAT	p.E332D	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	332	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			GTGTGGAAATCTCATTAGAAA	0.318			NA											13	35					4.3838e-07	9.07416e-07	0.001855	1	0
PABPC4	8761	broad.mit.edu	37	1	40038208	40038208	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:40038208T>C	uc010oiv.1	-	2	1142	c.244A>G	c.(244-246)ATC>GTC	p.I82V	PABPC4_uc001cdl.2_Missense_Mutation_p.I82V|PABPC4_uc001cdm.2_Missense_Mutation_p.I82V	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	82	RRM 1.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ATGATGCGGATTGGCTTTCCC	0.448			NA											17	46					0	0	0.007413	0	0
SLC5A9	200010	broad.mit.edu	37	1	48703369	48703369	+	Silent	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:48703369G>T	uc001cro.2	+	11	1363	c.1311G>T	c.(1309-1311)CTG>CTT	p.L437L	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Silent_p.L462L|SLC5A9_uc010omt.1_Silent_p.L451L|SLC5A9_uc001crp.2_Silent_p.L104L|SLC5A9_uc010omu.1_Silent_p.L104L|SLC5A9_uc009vyt.1_5'Flank	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	437	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						TGGTGTTCCTGGTTGTCATCA	0.577			NA											11	41					4.68919e-08	9.98561e-08	0.000673	1	0
C1orf175	374977	broad.mit.edu	37	1	55138776	55138776	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:55138776C>G	uc010ooe.1	+	8	1936	c.1612C>G	c.(1612-1614)CAG>GAG	p.Q538E	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.Q106E|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.Q56E|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.Q538E|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	538						integral to membrane	binding				0						TCTTTACCATCAGACCCTGGA	0.552			NA											8	24					0	0	0.004482	0	0
SGIP1	84251	broad.mit.edu	37	1	67147963	67147963	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:67147963C>A	uc001dcr.2	+	15	1443	c.1226C>A	c.(1225-1227)GCA>GAA	p.A409E	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.A176E	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	409	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						GGACAAAGAGCAACTCCACCT	0.512			NA											50	73					2.29192e-23	5.17868e-23	0.00361	1	0
VCAM1	7412	broad.mit.edu	37	1	101190420	101190420	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:101190420G>C	uc001dti.2	+	4	1022	c.902G>C	c.(901-903)AGA>ACA	p.R301T	VCAM1_uc001dtj.2_Missense_Mutation_p.R301T|VCAM1_uc010ouj.1_Missense_Mutation_p.R239T	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	301	Ig-like C2-type 3.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GGGAAAAACAGAAAAGAGGTG	0.378			NA											3	24					0	0	0.000248	0	0
VCAM1	7412	broad.mit.edu	37	1	101194797	101194797	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:101194797C>G	uc001dti.2	+	5	1183	c.1063C>G	c.(1063-1065)CTG>GTG	p.L355V	VCAM1_uc001dtj.2_Intron|VCAM1_uc010ouj.1_Missense_Mutation_p.L293V	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	355	Ig-like C2-type 4.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGACAGCCCTCTGAGCGGGAA	0.527			NA											18	73					0	0	0.006122	0	0
ADORA3	140	broad.mit.edu	37	1	112042915	112042915	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:112042915C>T	uc001ebh.3	-	2	1381	c.614G>A	c.(613-615)CGG>CAG	p.R205Q	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Intron	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	205	Cytoplasmic (By similarity).				activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GAGTTTGTTCCGAATGATGTA	0.428			NA											10	33					0	0	0.006214	0	0
FAM20B	9917	broad.mit.edu	37	1	179013004	179013004	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:179013004G>T	uc001gmc.2	+	2	315	c.22G>T	c.(22-24)GTG>TTG	p.V8L		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	8	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						GCAGCGAGTCGTGCTGTTAGC	0.468			NA											7	30					5.18039e-06	1.04313e-05	0.00308	1	0
KIF14	9928	broad.mit.edu	37	1	200539118	200539118	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:200539118C>T	uc010ppk.1	-	23	4021	c.3582G>A	c.(3580-3582)ATG>ATA	p.M1194I	KIF14_uc010ppj.1_Missense_Mutation_p.M703I	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1194	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCTGTTCTTCATCAAACTCC	0.289			NA											18	46					0	0	0.007413	0	0
USH2A	7399	broad.mit.edu	37	1	216172259	216172259	+	Silent	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:216172259T>C	uc001hku.1	-	34	7014	c.6627A>G	c.(6625-6627)TTA>TTG	p.L2209L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2209	Extracellular (Potential).|Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATTACCAGGTAAAACGTATT	0.373			NA								HNSCC(13;0.011)			9	23					0	0	0.006214	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285607	248285607	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:248285607C>T	uc001idy.1	+	1	170	c.170C>T	c.(169-171)GCC>GTC	p.A57V		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						TGCTACATTGCCATTTGCCAC	0.433			NA											28	139					0	0	0.00632	0	0
RET	5979	broad.mit.edu	37	10	43596058	43596058	+	Silent	SNP	G	G	A	rs151267865	byFrequency	TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr10:43596058G>A	uc001jal.2	+	2	415	c.225G>A	c.(223-225)ACG>ACA	p.T75T	RET_uc001jak.1_Silent_p.T75T	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	75	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TCTACGGCACGTACCGCACAC	0.647	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				7	26					0	0	0.001984	0	0
SLC25A16	8034	broad.mit.edu	37	10	70248311	70248311	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr10:70248311G>A	uc001joi.2	-	7	1138	c.686C>T	c.(685-687)TCA>TTA	p.S229L	SLC25A16_uc010qix.1_Missense_Mutation_p.S95L|SLC25A16_uc010qiy.1_Missense_Mutation_p.S131L|SLC25A16_uc001joj.2_Missense_Mutation_p.S131L	NM_152707	NP_689920	P16260	GDC_HUMAN	solute carrier family 25, member 16	229					coenzyme biosynthetic process|pantothenate metabolic process	integral to membrane|mitochondrial inner membrane	binding|solute:solute antiporter activity				0						ATTGTCTGATGAAGGTCTGCC	0.383			NA											5	31					0	0	0.00308	0	0
SAMD8	142891	broad.mit.edu	37	10	76924415	76924415	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr10:76924415C>T	uc001jwx.1	+	3	694	c.591C>T	c.(589-591)ATC>ATT	p.I197I	SAMD8_uc001jwy.1_Silent_p.I197I	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	197					sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TTCCTAGAATCCCATGGGCCT	0.408			NA											14	79					0	0	0.003163	0	0
F2	2147	broad.mit.edu	37	11	46744741	46744741	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:46744741G>A	uc001ndf.3	+	5	371	c.328G>A	c.(328-330)GAG>AAG	p.E110K	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	110	Kringle 1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	TAACTGTGCTGAGGGTCTGGG	0.582	Esophageal Squamous(147;1147 1808 2148 38609 51144)		NA											25	95					0	0	0.00632	0	0
GLYAT	10249	broad.mit.edu	37	11	58480243	58480243	+	Silent	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:58480243T>C	uc001nnb.2	-	4	461	c.306A>G	c.(304-306)TTA>TTG	p.L102L	GLYAT_uc001nnc.2_Silent_p.L102L	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	102					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TTTGAATCTGTAAATGCTGTT	0.408			NA											15	39					0	0	0.003163	0	0
STX3	6809	broad.mit.edu	37	11	59564823	59564823	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:59564823C>T	uc001nog.2	+	10	1044	c.854C>T	c.(853-855)TCC>TTC	p.S285F	STX3_uc010rkx.1_Intron|STX3_uc010rky.1_Intron|STX3_uc009ymt.1_Missense_Mutation_p.S151F	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	285	Extracellular (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						ATTGGACTTTCCGTTGGGCTG	0.403			NA											8	58					0	0	0.006214	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61672051	61672051	+	Missense_Mutation	SNP	A	A	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:61672051A>T	uc001nso.2	-	7	1024	c.866T>A	c.(865-867)GTG>GAG	p.V289E	RAB3IL1_uc001nsp.2_Missense_Mutation_p.V263E	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	289							protein binding			skin(2)|central_nervous_system(1)	3						GGCCACCTTCACTGTGGGCAG	0.617			NA											23	19					0	0	0.00278	0	0
NXF1	10482	broad.mit.edu	37	11	62566046	62566046	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:62566046C>T	uc001nvf.1	-	11	1154	c.1018G>A	c.(1018-1020)GCC>ACC	p.A340T	NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Missense_Mutation_p.A383T|NXF1_uc010rmh.1_3'UTR	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	340	Interaction with THOC4.|LRR 3.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TCGCGAATGGCGCTGTCAAGA	0.502			NA											30	59					0	0	0.002096	0	0
C2CD3	26005	broad.mit.edu	37	11	73849987	73849987	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:73849987C>T	uc001ouu.2	-	5	960	c.733G>A	c.(733-735)GAG>AAG	p.E245K	C2CD3_uc001ouv.2_Missense_Mutation_p.E245K	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	245						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TCAGGGTTCTCTGCAAAGCAT	0.378			NA											11	19					0	0	0.000978	0	0
NAALAD2	10003	broad.mit.edu	37	11	89880534	89880534	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:89880534A>C	uc001pdf.3	+	3	340	c.231A>C	c.(229-231)GAA>GAC	p.E77D	NAALAD2_uc009yvx.2_Missense_Mutation_p.E77D|NAALAD2_uc009yvy.2_Missense_Mutation_p.E77D|NAALAD2_uc001pdd.2_Missense_Mutation_p.E77D|NAALAD2_uc001pde.2_Missense_Mutation_p.E77D	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	77	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CAGGAACAGAACAAAATTTCT	0.378			NA											20	26					0	0	0.001216	0	0
B3GAT1	27087	broad.mit.edu	37	11	134253852	134253852	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr11:134253852G>T	uc001qhq.2	-	4	604	c.343C>A	c.(343-345)CTC>ATC	p.L115I	B3GAT1_uc001qhr.2_Missense_Mutation_p.L115I|B3GAT1_uc010scv.1_Missense_Mutation_p.L128I	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	115	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		AGCCAGTGGAGGTTGGGCACG	0.706			NA											9	4					1.76689e-08	3.78986e-08	0.006214	1	0
GALNT8	26290	broad.mit.edu	37	12	4835792	4835792	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr12:4835792G>A	uc001qne.1	+	2	398	c.306G>A	c.(304-306)ATG>ATA	p.M102I		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	102	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						TAAAGGCAATGGAAACCAAGG	0.453	Colon(108;631 1558 7270 20097 39846)		NA											10	4					0	0	0.006214	0	0
PKP2	5318	broad.mit.edu	37	12	33003796	33003796	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr12:33003796C>G	uc001rlj.3	-	5	1397	c.1282G>C	c.(1282-1284)GAC>CAC	p.D428H	PKP2_uc001rlk.3_Missense_Mutation_p.D428H|PKP2_uc010skj.1_Missense_Mutation_p.D428H	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	428	ARM 3.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AATTTGTTGTCATTGTCTTCA	0.463			NA											28	60					0	0	0.002445	0	0
C12orf52	84934	broad.mit.edu	37	12	113629333	113629333	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr12:113629333C>T	uc001tur.1	+	4	989	c.521C>T	c.(520-522)CCG>CTG	p.P174L	C12orf52_uc009zwg.1_Missense_Mutation_p.P171L|C12orf52_uc001tus.1_Missense_Mutation_p.P174L|C12orf52_uc001tut.1_Missense_Mutation_p.P198L	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	174	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						AAGACAGAGCCGGGGCCAGCG	0.637			NA											4	29					0	0	0.000248	0	0
MLEC	9761	broad.mit.edu	37	12	121132786	121132786	+	Missense_Mutation	SNP	T	T	G	rs144903763		TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr12:121132786T>G	uc001tyy.1	+	3	725	c.574T>G	c.(574-576)TAC>GAC	p.Y192D		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	192	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						AGGGAAACTCTACATTGAGTT	0.493			NA											38	93					0	0	0.003755	0	0
SETD8	387893	broad.mit.edu	37	12	123892161	123892161	+	Silent	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr12:123892161C>A	uc001uew.2	+	8	1012	c.970C>A	c.(970-972)CGA>AGA	p.R324R	SETD8_uc001uex.2_Silent_p.R259R	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	365	SET.				cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		CATCGCCTCCCGAGACATCGC	0.572			NA											4	28					0.00116845	0.00230573	0.001168	1	0
ZNF664	144348	broad.mit.edu	37	12	124497004	124497004	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr12:124497004C>T	uc001ufz.2	+	6	2143	c.313C>T	c.(313-315)CAT>TAT	p.H105Y	ZNF664_uc001uga.2_Missense_Mutation_p.H105Y|ZNF664_uc001ugb.2_Missense_Mutation_p.H105Y	NM_152437	NP_689650	Q8N3J9	ZN664_HUMAN	zinc finger protein 664	105	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		TCTTCAAATTCATATGAGAGT	0.408			NA											11	68					0	0	0.001368	0	0
IL17D	53342	broad.mit.edu	37	13	21295883	21295883	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr13:21295883C>A	uc001unm.2	+	3	507	c.399C>A	c.(397-399)AGC>AGA	p.S133R		NM_138284	NP_612141	Q8TAD2	IL17D_HUMAN	interleukin 17D precursor	133					inflammatory response	extracellular space	cytokine activity				0		all_cancers(29;9.63e-24)|all_epithelial(30;1.09e-19)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000301)|Epithelial(112;0.000633)|OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Lung(94;0.0154)|LUSC - Lung squamous cell carcinoma(192;0.0414)		GCTTCCGCAGCGCCCCTGTCT	0.716			NA											17	18					1.15088e-07	2.43328e-07	0.004007	1	0
LNX2	222484	broad.mit.edu	37	13	28141976	28141976	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr13:28141976G>C	uc001url.3	-	4	965	c.656C>G	c.(655-657)ACC>AGC	p.T219S	LNX2_uc001urm.1_Missense_Mutation_p.T219S	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	219							zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CTGTTGTGTGGCTGCCAAGTT	0.363			NA											5	27					0	0	0.001168	0	0
FLT3	2322	broad.mit.edu	37	13	28636175	28636175	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr13:28636175G>T	uc001urw.2	-	3	279	c.197C>A	c.(196-198)GCG>GAG	p.A66E	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.A66E	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	66	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.599_560>LTGSSDNEYFYVDFREYEY(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GGGTCTCAACGCACACCCGAG	0.537			NA	Mis|O		AML|ALL								66	23					7.1157e-29	1.62019e-28	0.00361	1	0
NBEA	26960	broad.mit.edu	37	13	36125086	36125086	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr13:36125086C>G	uc001uvb.2	+	43	6929	c.6723C>G	c.(6721-6723)TTC>TTG	p.F2241L	NBEA_uc010abi.2_Missense_Mutation_p.F897L|NBEA_uc010tee.1_Missense_Mutation_p.F34L|NBEA_uc010tef.1_Missense_Mutation_p.F34L|NBEA_uc010teg.1_Missense_Mutation_p.F34L	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2241						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGTTTAATTTCCCTGATCAAG	0.388			NA											14	27					0	0	0.00245	0	0
KIAA0564	23078	broad.mit.edu	37	13	42277540	42277540	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr13:42277540G>T	uc001uyj.2	-	27	3194	c.3124C>A	c.(3124-3126)CTG>ATG	p.L1042M		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1042						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TGTTCTGGCAGAGTCAACCTG	0.368			NA											8	15					9.70103e-10	2.12704e-09	0.000673	1	0
EFNB2	1948	broad.mit.edu	37	13	107148121	107148121	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr13:107148121C>T	uc001vqi.2	-	3	499	c.474G>A	c.(472-474)ATG>ATA	p.M158I		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	158	Extracellular (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					TGAGGATCTTCATGGCTCTTG	0.468			NA											38	103					0	0	0.006999	0	0
P704P	641455	broad.mit.edu	37	14	20020001	20020001	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:20020001C>T	uc001vwc.3	-	1	272	c.220G>A	c.(220-222)GGG>AGG	p.G74R	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	74											0						TTGCCGCTCCCCCTGCACCAG	0.587			NA											190	499					0	0	0.00361	0	0
RNASE12	493901	broad.mit.edu	37	14	21058512	21058512	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:21058512G>A	uc001vxt.2	-	1	471	c.371C>T	c.(370-372)TCC>TTC	p.S124F	RNASE11_uc010ahv.2_5'Flank|RNASE11_uc010ahx.2_5'Flank|RNASE11_uc010ahw.2_5'Flank|RNASE11_uc001vxs.2_5'Flank|uc001vxu.1_5'Flank	NM_001024822	NP_001019993	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	124						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		CTCTGTGGGGGAATAGTGGTA	0.458			NA											10	55					0	0	0.000978	0	0
C14orf37	145407	broad.mit.edu	37	14	58605804	58605804	+	Silent	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:58605804C>G	uc001xdc.2	-	2	384	c.273G>C	c.(271-273)TCG>TCC	p.S91S	C14orf37_uc010tro.1_Silent_p.S129S|C14orf37_uc001xdd.2_Silent_p.S91S|C14orf37_uc001xde.2_Silent_p.S91S	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	91	Extracellular (Potential).					integral to membrane	binding				0						CTTTGTTAATCGAGAATGCTT	0.488			NA											8	66					0	0	0.00308	0	0
ARID4A	5926	broad.mit.edu	37	14	58831658	58831658	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:58831658C>G	uc001xdp.2	+	20	3105	c.2851C>G	c.(2851-2853)CTG>GTG	p.L951V	ARID4A_uc001xdo.2_Missense_Mutation_p.L951V|ARID4A_uc001xdq.2_Missense_Mutation_p.L951V|ARID4A_uc010apg.1_Missense_Mutation_p.L629V	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	951	Retinoblastoma protein binding (Potential).				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TGCAATGCCTCTGATCGGGCC	0.408			NA											24	49					0	0	0.00278	0	0
C14orf169	79697	broad.mit.edu	37	14	73957841	73957841	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:73957841G>A	uc001xok.1	+	1	198	c.119G>A	c.(118-120)CGA>CAA	p.R40Q	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	40					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		AGGAAGATACGAAAGCAGCTG	0.672			NA											5	47					0	0	0.001168	0	0
ISM2	145501	broad.mit.edu	37	14	77942387	77942387	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:77942387G>T	uc001xtz.2	-	7	1341	c.1267C>A	c.(1267-1269)CTG>ATG	p.L423M	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.L335M|ISM2_uc010tvl.1_Missense_Mutation_p.L342M	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	423	AMOP.					extracellular region				skin(1)	1						AGGTCCCGCAGCATCTGGCTC	0.607			NA											67	12					7.577e-32	1.7386e-31	0.00361	1	0
TRIP11	9321	broad.mit.edu	37	14	92480716	92480716	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:92480716C>G	uc001xzy.2	-	7	1817	c.1029G>C	c.(1027-1029)AAG>AAC	p.K343N	TRIP11_uc010auf.1_Missense_Mutation_p.K108N	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	343	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTATTTGTCTCTTTTCCACAT	0.303	Ovarian(84;609 1888 9852 42686)		NA	T	PDGFRB	AML								15	32					0	0	0.003163	0	0
C14orf68	283600	broad.mit.edu	37	14	100793565	100793565	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:100793565C>T	uc001yhc.2	+	4	258	c.185C>T	c.(184-186)ACG>ATG	p.T62M	C14orf68_uc001yhd.2_Translation_Start_Site	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	62	Solcar 1.|Helical; Name=2; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				CCCGTGTGCACGGTGTCCCTG	0.667			NA											15	99					0	0	0.004007	0	0
BUB1B	701	broad.mit.edu	37	15	40475921	40475921	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr15:40475921C>G	uc001zkx.3	+	6	800	c.588C>G	c.(586-588)TTC>TTG	p.F196L	BUB1B_uc010ucl.1_Missense_Mutation_p.F59L	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	196	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTAGACAATTCCAAGCTCGAG	0.398			NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				6	10					0	0	0.00308	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42375420	42375420	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr15:42375420C>G	uc001zox.2	-	8	743	c.648G>C	c.(646-648)GAG>GAC	p.E216D		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	216					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TCAGCTCTGTCTCTAGGGCTG	0.622			NA											8	15					0	0	0.004482	0	0
PML	5371	broad.mit.edu	37	15	74325578	74325578	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr15:74325578G>T	uc002awv.2	+	6	1620	c.1480G>T	c.(1480-1482)GAG>TAG	p.E494*	PML_uc002awm.2_Nonsense_Mutation_p.E494*|PML_uc002awl.2_Intron|PML_uc002awj.1_Nonsense_Mutation_p.E446*|PML_uc002awk.2_Nonsense_Mutation_p.E494*|PML_uc002awn.2_Nonsense_Mutation_p.E494*|PML_uc002awo.2_Nonsense_Mutation_p.E446*|PML_uc002awp.2_Intron|PML_uc002awq.2_Nonsense_Mutation_p.E494*|PML_uc002awr.2_Nonsense_Mutation_p.E494*|PML_uc002aws.2_Nonsense_Mutation_p.E446*|PML_uc002awt.2_Intron|PML_uc002awu.2_Nonsense_Mutation_p.E446*|PML_uc010ule.1_Nonsense_Mutation_p.E55*|PML_uc002awx.2_Nonsense_Mutation_p.E204*|PML_uc002awy.2_5'UTR	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	494					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						GATGGAGTCTGAGGAGGGGAA	0.612			NA	T	RARA|PAX5	APL|ALL								10	19					7.48243e-07	1.53805e-06	0.006214	1	0
HAPLN3	145864	broad.mit.edu	37	15	89421266	89421266	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr15:89421266G>A	uc002bnc.2	-	5	1146	c.1018C>T	c.(1018-1020)CGA>TGA	p.R340*	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Nonsense_Mutation_p.R402*	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	340	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					CCAAAGCTTCGGACCCCAGGC	0.662			NA											8	32					0	0	0.00308	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923359	9923359	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr16:9923359G>C	uc002czo.3	-	9	2476	c.1928C>G	c.(1927-1929)GCT>GGT	p.A643G	GRIN2A_uc010uym.1_Missense_Mutation_p.A643G|GRIN2A_uc010uyn.1_Missense_Mutation_p.A486G|GRIN2A_uc002czr.3_Missense_Mutation_p.A643G	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	643	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTGTAGCTAGCCAGGAATAT	0.502			NA											4	59					0	0	0.000602	0	0
NOMO1	23420	broad.mit.edu	37	16	14972646	14972646	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr16:14972646C>T	uc002dcv.2	+	23	2778	c.2712C>T	c.(2710-2712)TCC>TCT	p.S904S		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	904	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						TGTTTCGTTCCAACCTCTTGA	0.537			NA											42	123					0	0	0.00361	0	0
GLG1	2734	broad.mit.edu	37	16	74525005	74525005	+	Missense_Mutation	SNP	A	A	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr16:74525005A>G	uc002fcy.3	-	8	1393	c.1343T>C	c.(1342-1344)ATT>ACT	p.I448T	GLG1_uc002fcx.2_Missense_Mutation_p.I448T|GLG1_uc002fcw.3_Missense_Mutation_p.I437T|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	448	Extracellular (Potential).|Cys-rich GLG1 6.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						ATGGTGTTCAATCTCCCCCCG	0.522			NA											19	64					0	0	0.001216	0	0
POLR2A	5430	broad.mit.edu	37	17	7417451	7417451	+	Silent	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr17:7417451C>A	uc002ghf.3	+	29	6102	c.5868C>A	c.(5866-5868)CTC>CTA	p.L1956L		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1956	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].|52; approximate.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CCTACAGTCTCACAAGCCCGG	0.527			NA											7	22					3.09899e-07	6.45986e-07	0.004482	1	0
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	T	C	rs121912666		TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	8					0	0	0.004007	0	0
NLK	51701	broad.mit.edu	37	17	26512286	26512286	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr17:26512286G>C	uc010crj.2	+	8	1443	c.1231G>C	c.(1231-1233)GAT>CAT	p.D411H	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	411	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GTTGGTCTTTGATCCAGTAAG	0.333			NA											3	8					0	0	0.004672	0	0
GOSR2	9570	broad.mit.edu	37	17	45016025	45016025	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr17:45016025C>T	uc002ila.2	+	6	611	c.538C>T	c.(538-540)CGG>TGG	p.R180W	GOSR2_uc010wkh.1_Missense_Mutation_p.R180W|GOSR2_uc002ikz.2_Missense_Mutation_p.R180W	NM_004287	NP_004278	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2 isoform A	180	Cytoplasmic (Potential).				cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(9;0.102)			CACAGTGATGCGGCTCATCGA	0.493			NA											41	139					0	0	0.001951	0	0
TTLL6	284076	broad.mit.edu	37	17	46846427	46846427	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr17:46846427C>T	uc010wlo.1	-	16	2635	c.2600G>A	c.(2599-2601)AGG>AAG	p.R867K	TTLL6_uc002iob.2_Missense_Mutation_p.R560K|TTLL6_uc010dbi.2_Intron|TTLL6_uc002ioc.2_Missense_Mutation_p.R620K|TTLL6_uc002iod.2_Intron	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	819						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						ACATGGGTCCCTCATAGCACT	0.507			NA											11	50					0	0	0.000673	0	0
CCDC47	57003	broad.mit.edu	37	17	61842114	61842114	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr17:61842114T>C	uc002jbs.3	-	3	694	c.358A>G	c.(358-360)ATA>GTA	p.I120V	CCDC47_uc010ddx.2_Missense_Mutation_p.I120V|CCDC47_uc002jbt.2_Missense_Mutation_p.I120V	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	120						integral to membrane	protein binding				0						ACAATCGTTATTGGGTCTTTA	0.343			NA											13	31					0	0	0.004007	0	0
SERPINB10	5273	broad.mit.edu	37	18	61582871	61582871	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr18:61582871T>C	uc010xev.1	+	2	217	c.127T>C	c.(127-129)TAT>CAT	p.Y43H	SERPINB2_uc002ljp.1_Missense_Mutation_p.Y184H|SERPINB2_uc002ljq.1_Missense_Mutation_p.Y157H|SERPINB10_uc010xew.1_Missense_Mutation_p.Y43H	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	43						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				GACCATAGTGTATTTGGGCGC	0.453			NA											17	17					0	0	0.00499	0	0
FBXW9	84261	broad.mit.edu	37	19	12807158	12807158	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:12807158G>C	uc010dyx.2	-	1	238	c.238C>G	c.(238-240)CTG>GTG	p.L80V	FBXW9_uc010xmp.1_RNA|FBXW9_uc002mum.1_Missense_Mutation_p.L80V|FBXW9_uc002mun.1_5'UTR	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	80	F-box.						protein binding			ovary(1)	1						GGAAGGCTCAGAAGGCCCGGC	0.711			NA											2	3					0	0	0.004672	0	0
OR10H2	26538	broad.mit.edu	37	19	15839226	15839226	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:15839226G>A	uc002nbm.2	+	1	393	c.373G>A	c.(373-375)GCC>ACC	p.A125T		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CCGCTACGTGGCCATCTGCCA	0.642			NA											15	13					0	0	0.00278	0	0
ZNF43	7594	broad.mit.edu	37	19	21990830	21990830	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:21990830A>C	uc002nqj.2	-	4	2139	c.2009T>G	c.(2008-2010)ATA>AGA	p.I670R	ZNF43_uc010ecv.2_Missense_Mutation_p.I664R|ZNF43_uc002nql.2_Missense_Mutation_p.I664R|ZNF43_uc002nqm.2_Missense_Mutation_p.I664R|ZNF43_uc002nqk.2_Missense_Mutation_p.I600R	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	670	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AGTATGAATTATCTTATGTTT	0.368			NA											3	49					0	0	0.000602	0	0
UBA2	10054	broad.mit.edu	37	19	34936003	34936003	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:34936003G>T	uc002nvk.2	+	8	818	c.748G>T	c.(748-750)GAT>TAT	p.D250Y	UBA2_uc010xrx.1_Missense_Mutation_p.D123Y|UBA2_uc002nvl.2_Missense_Mutation_p.D154Y	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	250					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			AACTGGATATGATCCAGTTAA	0.358			NA											23	35					7.88262e-20	1.76762e-19	0.00333	1	0
SPINT2	10653	broad.mit.edu	37	19	38779813	38779813	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:38779813G>A	uc002ohr.1	+	4	704	c.373G>A	c.(373-375)GAT>AAT	p.D125N	SPINT2_uc002ohs.1_Missense_Mutation_p.D68N	NM_021102	NP_066925	O43291	SPIT2_HUMAN	serine protease inhibitor, Kunitz type, 2	125	Extracellular (Potential).				cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity				0	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCACTCCAGCGATATGTTCAA	0.338			NA											40	53					0	0	0.002222	0	0
KDELR1	10945	broad.mit.edu	37	19	48887602	48887602	+	Silent	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:48887602G>C	uc002pjb.1	-	4	684	c.489C>G	c.(487-489)CTC>CTG	p.L163L	KDELR1_uc002pja.1_Silent_p.L101L	NM_006801	NP_006792	P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum	163	Helical; (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity				0		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		TCCAGTTGAAGAGATAGAGCG	0.562			NA											6	27					0	0	0.00308	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918513	51918513	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:51918513C>G	uc002pwo.2	-	7	1868	c.1252G>C	c.(1252-1254)GAG>CAG	p.E418Q	SIGLEC10_uc002pwp.2_Missense_Mutation_p.E360Q|SIGLEC10_uc002pwq.2_Missense_Mutation_p.E360Q|SIGLEC10_uc002pwr.2_Missense_Mutation_p.E418Q|SIGLEC10_uc010ycy.1_Missense_Mutation_p.E328Q|SIGLEC10_uc010ycz.1_Missense_Mutation_p.E370Q|SIGLEC10_uc010eow.2_Missense_Mutation_p.E230Q|SIGLEC10_uc002pws.1_Missense_Mutation_p.E254Q	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	418	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CCTTCGTGCTCCACTTGAACC	0.672			NA											12	50					0	0	0.001368	0	0
ZNF552	79818	broad.mit.edu	37	19	58319454	58319454	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:58319454G>T	uc002qqg.2	-	3	1348	c.1178C>A	c.(1177-1179)TCT>TAT	p.S393Y	ZNF587_uc002qqb.2_Intron|ZNF552_uc010yhg.1_Missense_Mutation_p.S389Y	NM_024762	NP_079038	Q9H707	ZN552_HUMAN	zinc finger protein 552	393	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		ACGAAGTGAAGAGATTTGCCT	0.413			NA											11	70					7.03913e-09	1.53205e-08	0.001368	1	0
HSPC159	29094	broad.mit.edu	37	2	64685477	64685477	+	Missense_Mutation	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:64685477T>C	uc002scy.3	+	5	787	c.434T>C	c.(433-435)TTT>TCT	p.F145S		NM_014181	NP_054900	Q3ZCW2	LEGL_HUMAN	galectin-related protein	145	Galectin.					intracellular	sugar binding				0						CACCAACTTTTTGATTTTTAC	0.393			NA											62	96					0	0	0.00361	0	0
SLC20A1	6574	broad.mit.edu	37	2	113420601	113420601	+	Silent	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:113420601G>A	uc002tib.2	+	11	2485	c.2039G>A	c.(2038-2040)TGA>TAA	p.*680*		NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	680					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						CTCAGAATGTGAAGCTGTTTG	0.403			NA											13	78					0	0	0.003163	0	0
ERMN	57471	broad.mit.edu	37	2	158177848	158177848	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:158177848G>A	uc002tzh.2	-	3	1052	c.790C>T	c.(790-792)CGG>TGG	p.R264W	ERMN_uc010zcj.1_Missense_Mutation_p.R158W|ERMN_uc010zck.1_Missense_Mutation_p.R244W|ERMN_uc002tzi.2_Missense_Mutation_p.R277W	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	264						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						CTGATTTTCCGATAGGATATT	0.393			NA											14	102					0	0	0.00245	0	0
ZAK	51776	broad.mit.edu	37	2	174081930	174081930	+	Missense_Mutation	SNP	A	A	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:174081930A>C	uc002uhz.2	+	11	1139	c.939A>C	c.(937-939)AGA>AGC	p.R313S	ZAK_uc002uhy.2_Missense_Mutation_p.R313S|ZAK_uc010zei.1_Missense_Mutation_p.R212S|ZAK_uc002uia.1_Missense_Mutation_p.R313S|uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	313					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			AACGAGAAAGACGTTTAAAGA	0.522			NA											8	32					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179604792	179604792	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:179604792C>G	uc010zfh.1	-	46	12879	c.12655G>C	c.(12655-12657)GAG>CAG	p.E4219Q	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4152Q|TTN_uc010zfj.1_Missense_Mutation_p.E4027Q|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATCTCTGCTCTTCTGGAATA	0.468			NA											20	28					0	0	0.001216	0	0
NRP2	8828	broad.mit.edu	37	2	206590657	206590657	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:206590657C>A	uc002vaw.2	+	6	1632	c.841C>A	c.(841-843)CTG>ATG	p.L281M	NRP2_uc002vat.2_Missense_Mutation_p.L281M|NRP2_uc002vau.2_Missense_Mutation_p.L281M|NRP2_uc002vav.2_Missense_Mutation_p.L281M|NRP2_uc002vax.2_Missense_Mutation_p.L281M|NRP2_uc002vay.2_Missense_Mutation_p.L281M|NRP2_uc010fud.2_Missense_Mutation_p.L281M	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	281	Extracellular (Potential).|F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CAATGTTCCTCTGGGCATGGA	0.537			NA											13	41					0.000219431	0.000435917	0.00245	1	0
SLC4A3	6508	broad.mit.edu	37	2	220494078	220494078	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:220494078G>A	uc002vmp.3	+	4	699	c.430G>A	c.(430-432)GAG>AAG	p.E144K	SLC4A3_uc002vmn.2_Missense_Mutation_p.E144K|SLC4A3_uc002vmo.3_Missense_Mutation_p.E144K|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'Flank	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	144	Poly-Glu.|Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		agaggaggaagaggaAGGAGA	0.527			NA											3	9					0	0	0.000602	0	0
RALGAPB	57148	broad.mit.edu	37	20	37202806	37202806	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr20:37202806G>C	uc002xiw.2	+	29	4413	c.4156G>C	c.(4156-4158)GAA>CAA	p.E1386Q	RALGAPB_uc002xix.2_Missense_Mutation_p.E1383Q|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.E1165Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1386	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TACAACTCTTGAAAAAGAAGT	0.398			NA											9	78					0	0	0.004482	0	0
KCNQ2	3785	broad.mit.edu	37	20	62038708	62038708	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr20:62038708C>G	uc002yey.1	-	17	2085	c.1908G>C	c.(1906-1908)AAG>AAC	p.K636N	KCNQ2_uc002yez.1_Missense_Mutation_p.K605N|KCNQ2_uc002yfa.1_Missense_Mutation_p.K618N|KCNQ2_uc002yfb.1_Missense_Mutation_p.K608N	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	636	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GGAAGTCCAGCTTCTTCTCCA	0.642			NA											6	29					0	0	0.001168	0	0
GRIK1	2897	broad.mit.edu	37	21	30933950	30933950	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr21:30933950G>A	uc002yno.1	-	15	2815	c.2351C>T	c.(2350-2352)CCT>CTT	p.P784L	GRIK1_uc002ynn.2_Missense_Mutation_p.P769L|GRIK1_uc011acs.1_Missense_Mutation_p.P784L|GRIK1_uc011act.1_Missense_Mutation_p.P645L	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	784	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CTTACCAATAGGTGTTCCCAC	0.468			NA											6	11					0	0	0.001168	0	0
TTC3	7267	broad.mit.edu	37	21	38537922	38537922	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr21:38537922G>C	uc002yvz.2	+	33	3511	c.3406G>C	c.(3406-3408)GAG>CAG	p.E1136Q	TTC3_uc011aee.1_Missense_Mutation_p.E826Q|TTC3_uc002ywa.2_Missense_Mutation_p.E1136Q|TTC3_uc002ywb.2_Missense_Mutation_p.E1136Q|TTC3_uc010gnf.2_Missense_Mutation_p.E901Q|TTC3_uc002ywc.2_Missense_Mutation_p.E826Q|TTC3_uc002ywd.1_Missense_Mutation_p.E200Q	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1136					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TGCAGAATATGAGTTTTTCCC	0.373	Ovarian(38;194 1649 35661)		NA											33	113					0	0	0.003755	0	0
PCNT	5116	broad.mit.edu	37	21	47855999	47855999	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr21:47855999G>C	uc002zji.3	+	39	9041	c.8934G>C	c.(8932-8934)ATG>ATC	p.M2978I	PCNT_uc002zjj.2_Missense_Mutation_p.M2781I	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2978	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGGAGGCGATGAGGCAGCGGC	0.697			NA											10	21					0	0	0.006214	0	0
TMEM184B	25829	broad.mit.edu	37	22	38641953	38641953	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr22:38641953C>T	uc003avf.1	-	3	570	c.346G>A	c.(346-348)GAC>AAC	p.D116N	TMEM184B_uc003avg.1_Missense_Mutation_p.D116N|TMEM184B_uc003avh.1_Missense_Mutation_p.D50N|TMEM184B_uc010gxl.1_RNA	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	116						integral to membrane					0	Melanoma(58;0.045)					TCATAGCAGTCGCGGACGGTG	0.642			NA											5	9					0	0	0.001168	0	0
FEZF2	55079	broad.mit.edu	37	3	62358290	62358290	+	Nonsense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr3:62358290G>C	uc003dlh.2	-	1	461	c.254C>G	c.(253-255)TCA>TGA	p.S85*	FEZF2_uc003dli.2_Nonsense_Mutation_p.S85*	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	85					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		CAGTGTCTTTGACGGCACCTC	0.507	NSCLC(170;1772 2053 12525 15604 23984)		NA											5	15					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	3	126915686	126915686	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr3:126915686C>A	uc003eji.1	+	2	398	c.158C>A	c.(157-159)ACT>AAT	p.T53N						RecName: Full=Putative uncharacterized protein C3orf56;												NA						CAGCCTGTAACTGACCTGGCC	0.612			NA											11	5					1.58986e-06	3.24552e-06	0.000673	1	0
SHROOM3	57619	broad.mit.edu	37	4	77476912	77476912	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr4:77476912C>T	uc011cbx.1	+	2	1272	c.319C>T	c.(319-321)CGC>TGC	p.R107C		NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	107	PDZ.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCTGGTAGTGCGCAGGTAGGT	0.393			NA											6	14					0	0	0.001168	0	0
NHEDC1	150159	broad.mit.edu	37	4	103910990	103910990	+	Silent	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr4:103910990G>A	uc003hww.2	-	3	300	c.178C>T	c.(178-180)CTA>TTA	p.L60L	NHEDC1_uc003hwu.2_Silent_p.L60L|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	60						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		ACTCCTCTTAGAGGACAAGAA	0.284			NA											7	13					0	0	0.004482	0	0
SCLT1	132320	broad.mit.edu	37	4	129857944	129857944	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr4:129857944C>G	uc003igp.2	-	18	2201	c.1695G>C	c.(1693-1695)GAG>GAC	p.E565D	SCLT1_uc003ign.2_Missense_Mutation_p.E229D|SCLT1_uc003igo.2_Missense_Mutation_p.E175D|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	565	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						TGTCTTCCATCTCTCTCAATT	0.343			NA											3	24					0	0	0.004672	0	0
PCDH18	54510	broad.mit.edu	37	4	138452016	138452016	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr4:138452016C>G	uc003ihe.3	-	1	1614	c.1227G>C	c.(1225-1227)AAG>AAC	p.K409N	PCDH18_uc003ihf.3_Missense_Mutation_p.K402N|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.K189N|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	409	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TTTCATATGTCTTCTGAAGTT	0.383			NA											21	33					0	0	0.001882	0	0
LPCAT1	79888	broad.mit.edu	37	5	1479756	1479756	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:1479756G>A	uc003jcm.2	-	8	913	c.796C>T	c.(796-798)CAC>TAC	p.H266Y		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	266	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		ACTTGGTTGTGAAACTGACAC	0.448			NA									OREG0016481	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	20					0	0	0.001984	0	0
DNAH5	1767	broad.mit.edu	37	5	13692194	13692194	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:13692194G>C	uc003jfd.2	-	79	13816	c.13774C>G	c.(13774-13776)CGA>GGA	p.R4592G	DNAH5_uc003jfc.2_Missense_Mutation_p.R760G	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4592					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGTCCGTTCGAACTGGCTTC	0.468			NA							Kartagener_syndrome				11	45					0	0	0.001368	0	0
DNAH5	1767	broad.mit.edu	37	5	13830323	13830323	+	Splice_Site	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:13830323C>T	uc003jfd.2	-	37	6104	c.6062_splice	c.e37-1	p.G2021_splice		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGTGCCAGTCCTTCGAAAGGA	0.363			NA							Kartagener_syndrome				13	11					0	0	0.001855	0	0
CMYA5	202333	broad.mit.edu	37	5	79032782	79032782	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:79032782G>T	uc003kgc.2	+	2	8266	c.8194G>T	c.(8194-8196)GAT>TAT	p.D2732Y		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2732						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTCTTGTCATGATGAAATAGA	0.393			NA											10	19					2.17888e-05	4.35775e-05	0.006214	1	0
APC	324	broad.mit.edu	37	5	112154981	112154981	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:112154981G>C	uc010jby.2	+	10	1632	c.1252G>C	c.(1252-1254)GAA>CAA	p.E418Q	APC_uc011cvt.1_Missense_Mutation_p.E400Q|APC_uc003kpz.3_Missense_Mutation_p.E418Q|APC_uc003kpy.3_Missense_Mutation_p.E418Q|APC_uc010jbz.2_Missense_Mutation_p.E135Q|APC_uc010jca.2_5'Flank	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	418	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CGCTTACTGTGAAACCTGTTG	0.468	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			6	26					0	0	0.00308	0	0
RAD50	10111	broad.mit.edu	37	5	131978009	131978009	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:131978009G>C	uc003kxi.2	+	25	4279	c.3892G>C	c.(3892-3894)GAG>CAG	p.E1298Q	RAD50_uc003kxh.2_Missense_Mutation_p.E1159Q	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1298					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCAGTGCTCAGAGATTGTGAA	0.358			NA						Homologous_recombination					6	22					0	0	0.001984	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139876307	139876307	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:139876307G>C	uc003lfs.1	+	15	2572	c.2448G>C	c.(2446-2448)AAG>AAC	p.K816N	ANKHD1_uc003lfq.1_Missense_Mutation_p.K835N|ANKHD1_uc003lfr.2_Missense_Mutation_p.K816N|ANKHD1_uc003lft.1_Intron|ANKHD1_uc003lfu.1_Missense_Mutation_p.K296N|ANKHD1_uc003lfv.1_Intron	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	816						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAAGATAAGATAGAAGAAC	0.373			NA											16	30					0	0	0.006122	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203499	140203499	+	Silent	SNP	G	G	A	rs151078612		TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:140203499G>A	uc003lhl.2	+	1	2139	c.2139G>A	c.(2137-2139)ACG>ACA	p.T713T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.T713T|PCDHA5_uc003lhj.1_Silent_p.T713T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	713	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGCTCACGCTGCTGCTGT	0.692			NA											14	34					0	0	0.001855	0	0
PCDHA9	9752	broad.mit.edu	37	5	140228143	140228143	+	Silent	SNP	C	C	T	rs146722772		TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:140228143C>T	uc003lhu.2	+	1	787	c.63C>T	c.(61-63)CTC>CTT	p.L21L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.L21L	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	21					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGATCCTCGCAATGTGGG	0.562	Melanoma(55;1800 1972 14909)		NA											30	48					0	0	0.001786	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764587	140764587	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:140764587C>T	uc003lka.1	+	1	2121	c.2121C>T	c.(2119-2121)TTC>TTT	p.F707F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGB4_uc003lkc.1_5'Flank|PCDHGA7_uc003ljz.1_Silent_p.F707F|PCDHGB4_uc011dav.1_5'Flank	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	707	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTAGCCTTCGTCCTCGTAC	0.627			NA											8	25					0	0	0.004482	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140779407	140779407	+	Missense_Mutation	SNP	C	C	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr5:140779407C>A	uc003lkf.1	+	1	1713	c.1713C>A	c.(1711-1713)TTC>TTA	p.F571L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.F571L	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	571	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGCTCTTCGATATGGTGC	0.667			NA											9	20					0.00448238	0.00878665	0.004482	1	0
OR14J1	442191	broad.mit.edu	37	6	29274772	29274772	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:29274772C>T	uc011dln.1	+	1	306	c.306C>T	c.(304-306)TTC>TTT	p.F102F		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTTCTTCTTCATAGCTCTGG	0.438			NA											16	213					0	0	0.00499	0	0
DNAH8	1769	broad.mit.edu	37	6	38885911	38885911	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:38885911C>G	uc003ooe.1	+	68	10468	c.9868C>G	c.(9868-9870)CTG>GTG	p.L3290V	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGTGTTGCCTCTGAAGGTAAA	0.373			NA											6	46					0	0	0.001168	0	0
C6orf226	441150	broad.mit.edu	37	6	42858486	42858486	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:42858486G>C	uc003osw.2	-	1	69	c.41C>G	c.(40-42)TCT>TGT	p.S14C		NM_001008739	NP_001008739	Q5I0X4	CF226_HUMAN	hypothetical protein LOC441150	14											0						AGCTGAGGCAGAGGCCGGGGC	0.672			NA											14	92					0	0	0.003163	0	0
GPR116	221395	broad.mit.edu	37	6	46847599	46847599	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:46847599G>A	uc003oyo.3	-	9	1281	c.992C>T	c.(991-993)TCG>TTG	p.S331L	GPR116_uc003oyp.3_Intron|GPR116_uc003oyq.3_Missense_Mutation_p.S331L|GPR116_uc010jzi.1_Missense_Mutation_p.S3L|GPR116_uc003oyr.2_Missense_Mutation_p.S331L	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	331	Ig-like 1.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CTTGGACACCGAAGTCATGTT	0.453	NSCLC(59;410 1274 8751 36715 50546)		NA											9	137					0	0	0.006214	0	0
REV3L	5980	broad.mit.edu	37	6	111714122	111714122	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:111714122G>C	uc003puy.3	-	5	942	c.619C>G	c.(619-621)CTT>GTT	p.L207V	REV3L_uc003pux.3_Missense_Mutation_p.L129V|REV3L_uc003puz.3_Missense_Mutation_p.L129V	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	207					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTATCAGCAAGAGAATTTCCT	0.313			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					5	16					0	0	0.001168	0	0
KPNA5	3841	broad.mit.edu	37	6	117023208	117023208	+	Silent	SNP	T	T	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:117023208T>C	uc003pxh.2	+	6	593	c.462T>C	c.(460-462)AAT>AAC	p.N154N		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	151	NLS binding site (major) (By similarity).|ARM 2.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		CATTAACAAATATAGCATCTG	0.244			NA											6	40					0	0	0.001984	0	0
LATS1	9113	broad.mit.edu	37	6	150004976	150004976	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:150004976G>C	uc003qmu.1	-	4	1797	c.1249C>G	c.(1249-1251)CAT>GAT	p.H417D	LATS1_uc010kif.1_Missense_Mutation_p.H312D|LATS1_uc003qmv.1_Missense_Mutation_p.H417D|LATS1_uc003qmw.2_Missense_Mutation_p.H417D|LATS1_uc010kig.1_Missense_Mutation_p.H312D	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	417					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TCCATGTTATGACTATTTCTG	0.453			NA											29	108					0	0	0.007291	0	0
SYNE1	23345	broad.mit.edu	37	6	152599341	152599341	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:152599341C>T	uc010kiw.2	-	98	19058	c.18456G>A	c.(18454-18456)CTG>CTA	p.L6152L	SYNE1_uc010kiv.2_Silent_p.L676L|SYNE1_uc003qos.3_Silent_p.L676L|SYNE1_uc003qot.3_Silent_p.L6081L|SYNE1_uc003qou.3_Silent_p.L6152L|SYNE1_uc010kiy.1_Silent_p.L331L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6152	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTTGCCCTCCAGCAGCAGGT	0.522			NA								HNSCC(10;0.0054)			31	89					0	0	0.001786	0	0
PDE10A	10846	broad.mit.edu	37	6	165863740	165863740	+	Silent	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr6:165863740G>A	uc003qun.2	-	5	547	c.306C>T	c.(304-306)ATC>ATT	p.I102I	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Silent_p.I32I|PDE10A_uc003quo.2_Silent_p.I112I	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	102	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CTATTTTAATGATGCTGCTCA	0.378	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											17	60					0	0	0.007413	0	0
ABCA13	154664	broad.mit.edu	37	7	48317992	48317992	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr7:48317992G>C	uc003toq.2	+	18	7226	c.7201G>C	c.(7201-7203)GAC>CAC	p.D2401H	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2401					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TAAGTCTGAGGACCTCTTCAA	0.383			NA											10	29					0	0	0.006214	0	0
PON2	5445	broad.mit.edu	37	7	95041643	95041643	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr7:95041643G>C	uc003unv.2	-	4	469	c.348C>G	c.(346-348)ATC>ATG	p.I116M	PON2_uc003unu.2_Missense_Mutation_p.I116M|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Missense_Mutation_p.I29M	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	116		Calcium 2; via carbonyl oxygen (By similarity).			aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			TGAAAGTGCTGATGCCATGTG	0.393	GBM(42;803 823 13649 23368 31463)		NA											20	38					0	0	0.00278	0	0
SLC12A9	56996	broad.mit.edu	37	7	100463720	100463720	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr7:100463720C>T	uc003uwp.2	+	14	2380	c.2238C>T	c.(2236-2238)CTC>CTT	p.L746L	SLC12A9_uc011kki.1_Silent_p.L277L|SLC12A9_uc003uwr.2_Silent_p.L482L|SLC12A9_uc003uws.2_Silent_p.L277L|SLC12A9_uc003uwt.2_Silent_p.L482L|SLC12A9_uc003uwv.2_Silent_p.L277L|TRIP6_uc010lhk.1_5'Flank|TRIP6_uc003uww.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	746	Helical; (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					TCTGCGGCCTCTTCCTGCTGC	0.697			NA											17	98					0	0	0.001216	0	0
RELN	5649	broad.mit.edu	37	7	103207077	103207077	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr7:103207077G>A	uc003vca.2	-	32	4878	c.4718C>T	c.(4717-4719)ACG>ATG	p.T1573M	RELN_uc010liz.2_Missense_Mutation_p.T1573M	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1573					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCGAAATGCCGTTGCAGGTGT	0.498	NSCLC(146;835 1944 15585 22231 52158)		NA											15	28					0	0	0.003163	0	0
FAM40B	57464	broad.mit.edu	37	7	129122844	129122844	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr7:129122844G>C	uc011koy.1	+	20	2251	c.2211G>C	c.(2209-2211)CAG>CAC	p.Q737H	FAM40B_uc003vow.2_Missense_Mutation_p.Q737H|FAM40B_uc011koz.1_Missense_Mutation_p.Q229H	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	737											0						CCATTTACCAGAAAGTGCGTC	0.468			NA											4	19					0	0	0.000248	0	0
TMEM176A	55365	broad.mit.edu	37	7	150498696	150498696	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr7:150498696G>C	uc003whx.1	+	2	136	c.58G>C	c.(58-60)GAT>CAT	p.D20H	TMEM176B_uc003wht.3_5'Flank|TMEM176B_uc003whu.3_5'Flank|TMEM176B_uc003whv.3_5'Flank|TMEM176B_uc003whw.3_5'Flank	NM_018487	NP_060957	Q96HP8	T176A_HUMAN	hepatocellular carcinoma-associated antigen 112	20						integral to membrane				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCCACATCGATGTGCACAT	0.652			NA											8	21					0	0	0.004482	0	0
AMAC1L2	83650	broad.mit.edu	37	8	11189308	11189308	+	Silent	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr8:11189308G>T	uc003wtp.1	+	1	814	c.693G>T	c.(691-693)CTG>CTT	p.L231L		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	231	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TGGTGGGGCTGCTGGGCTGTG	0.632			NA											10	62					2.27111e-07	4.76772e-07	0.001368	1	0
C8orf79	57604	broad.mit.edu	37	8	12879335	12879335	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr8:12879335G>A	uc010lsq.2	+	5	1639	c.1147G>A	c.(1147-1149)GAT>AAT	p.D383N	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.D296N|C8orf79_uc010lsr.2_Missense_Mutation_p.D257N	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	383							methyltransferase activity				0						TTCTGCAGTTGATTCCACAGA	0.413			NA											8	20					0	0	0.00308	0	0
OPRK1	4986	broad.mit.edu	37	8	54141989	54141989	+	Silent	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr8:54141989G>A	uc003xrh.1	-	3	1386	c.1011C>T	c.(1009-1011)TTC>TTT	p.F337F	OPRK1_uc003xri.1_Silent_p.F337F|OPRK1_uc010lyc.1_Silent_p.F248F	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	337	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	AACACCGCTTGAAGTTTTCAT	0.493			NA											4	40					0	0	0.000248	0	0
FLJ43860	389690	broad.mit.edu	37	8	142444085	142444085	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr8:142444085C>T	uc003ywi.2	-	32	4011	c.3930G>A	c.(3928-3930)CAG>CAA	p.Q1310Q	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1310							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCGACACCTTCTGGAGGAAGG	0.637			NA											5	17					0	0	0.000602	0	0
PLEC	5339	broad.mit.edu	37	8	144992130	144992130	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr8:144992130C>T	uc003zaf.1	-	32	12440	c.12270G>A	c.(12268-12270)ATG>ATA	p.M4090I	PLEC_uc003zab.1_Missense_Mutation_p.M3953I|PLEC_uc003zac.1_Missense_Mutation_p.M3957I|PLEC_uc003zad.2_Missense_Mutation_p.M3953I|PLEC_uc003zae.1_Missense_Mutation_p.M3921I|PLEC_uc003zag.1_Missense_Mutation_p.M3931I|PLEC_uc003zah.2_Missense_Mutation_p.M3939I|PLEC_uc003zaj.2_Missense_Mutation_p.M3980I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4090	Plectin 22.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGCCCTTCTTCATGGCCTGGT	0.612			NA											8	31					0	0	0.00308	0	0
PLEC	5339	broad.mit.edu	37	8	144992966	144992966	+	Missense_Mutation	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr8:144992966C>T	uc003zaf.1	-	32	11604	c.11434G>A	c.(11434-11436)GAG>AAG	p.E3812K	PLEC_uc003zab.1_Missense_Mutation_p.E3675K|PLEC_uc003zac.1_Missense_Mutation_p.E3679K|PLEC_uc003zad.2_Missense_Mutation_p.E3675K|PLEC_uc003zae.1_Missense_Mutation_p.E3643K|PLEC_uc003zag.1_Missense_Mutation_p.E3653K|PLEC_uc003zah.2_Missense_Mutation_p.E3661K|PLEC_uc003zaj.2_Missense_Mutation_p.E3702K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3812	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCGAGAGCCTCACGGAGGCTC	0.652			NA											9	51					0	0	0.000673	0	0
DMRT1	1761	broad.mit.edu	37	9	893951	893951	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:893951G>A	uc003zgv.2	+	3	727	c.578G>A	c.(577-579)AGC>AAC	p.S193N	DMRT1_uc003zgu.1_Missense_Mutation_p.S193N	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	193					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		GCTGTCACCAGCAGAGGGCAT	0.428			NA									OREG0019071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	15					0	0	0.001523	0	0
MPDZ	8777	broad.mit.edu	37	9	13121878	13121878	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:13121878C>T	uc010mia.1	-	37	5148	c.5091G>A	c.(5089-5091)CTG>CTA	p.L1697L	MPDZ_uc003zkx.3_5'Flank|MPDZ_uc003zky.3_Silent_p.L231L|MPDZ_uc010mib.2_Silent_p.L402L|MPDZ_uc010mhx.2_Silent_p.L519L|MPDZ_uc011lmm.1_Silent_p.L556L|MPDZ_uc003zkz.3_Silent_p.L390L|MPDZ_uc010mhy.2_Silent_p.L1697L|MPDZ_uc010mhz.2_Silent_p.L1664L|MPDZ_uc011lmn.1_Silent_p.L1664L|MPDZ_uc003zlb.3_Silent_p.L1697L	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1697	PDZ 10.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GCGTCTGTCTCAGGACATTGA	0.478			NA											5	22					0	0	0.000602	0	0
DENND4C	55667	broad.mit.edu	37	9	19372102	19372102	+	Silent	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:19372102G>A	uc003znq.2	+	28	4986	c.4953G>A	c.(4951-4953)CAG>CAA	p.Q1651Q	DENND4C_uc011lnc.1_Silent_p.Q981Q|DENND4C_uc011lnd.1_Silent_p.Q939Q|DENND4C_uc003znr.2_3'UTR|DENND4C_uc003zns.2_3'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1651						integral to membrane				ovary(1)|skin(1)	2						AAAGGTTGCAGAAAATTGATG	0.378			NA											24	58					0	0	0.003954	0	0
OR13J1	392309	broad.mit.edu	37	9	35869976	35869976	+	Silent	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:35869976G>A	uc011lph.1	-	1	423	c.423C>T	c.(421-423)TGC>TGT	p.C141C		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			TCAGCAGCACGCAGAGCCGGT	0.627			NA											7	34					0	0	0.001984	0	0
FRMPD1	22844	broad.mit.edu	37	9	37746696	37746696	+	Missense_Mutation	SNP	G	G	A			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:37746696G>A	uc004aag.1	+	16	4711	c.4667G>A	c.(4666-4668)CGT>CAT	p.R1556H	FRMPD1_uc004aah.1_Missense_Mutation_p.R1556H	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1556						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CTCCTGGCCCGTCAGTGCACG	0.592			NA											24	75					0	0	0.004656	0	0
FRMD3	257019	broad.mit.edu	37	9	86153022	86153022	+	Missense_Mutation	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:86153022G>C	uc004ams.1	-	1	327	c.125C>G	c.(124-126)TCG>TGG	p.S42W	FRMD3_uc004amr.1_Missense_Mutation_p.S28W	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	42	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						GGAGATCTCCGAGTCGTCCAG	0.652			NA											4	3					0	0	0.000248	0	0
ENG	2022	broad.mit.edu	37	9	130581094	130581094	+	Silent	SNP	G	G	C			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:130581094G>C	uc004bsj.3	-	11	1742	c.1329C>G	c.(1327-1329)CTC>CTG	p.L443L	ENG_uc011mam.1_Silent_p.L254L|ENG_uc004bsk.3_Silent_p.L443L|uc004bsl.1_Intron	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	443	Ser/Thr-rich.|Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						TGTCCATGTTGAGGCAGTGCA	0.627			NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				34	155					0	0	0.004878	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139302345	139302345	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:139302345C>G	uc004chi.2	-	4	540	c.335G>C	c.(334-336)AGA>ACA	p.R112T	SDCCAG3_uc004chj.2_Missense_Mutation_p.R89T|SDCCAG3_uc004chk.2_Missense_Mutation_p.R39T|PMPCA_uc011mdy.1_5'Flank|PMPCA_uc010nbk.2_5'Flank|PMPCA_uc004chl.2_5'Flank|PMPCA_uc010nbl.2_5'Flank|PMPCA_uc011mdz.1_5'Flank	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	112						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CAGAAACTCTCTAAAAGAGAA	0.448			NA											12	99					0	0	0.003163	0	0
KIAA1984	84960	broad.mit.edu	37	9	139697160	139697160	+	Silent	SNP	C	C	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr9:139697160C>T	uc004cjf.2	+	6	636	c.588C>T	c.(586-588)CTC>CTT	p.L196L		NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	196	Potential.									ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		TGCAGAACCTCGTGGTCAACT	0.562			NA											28	83					0	0	0.005443	0	0
ZC4H2	55906	broad.mit.edu	37	X	64139010	64139010	+	Missense_Mutation	SNP	G	G	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chrX:64139010G>T	uc004dvu.2	-	4	561	c.473C>A	c.(472-474)GCA>GAA	p.A158E	ZC4H2_uc004dvv.2_Missense_Mutation_p.A135E|ZC4H2_uc011mov.1_Missense_Mutation_p.A135E|ZC4H2_uc011mow.1_Intron|ZC4H2_uc004dvw.1_3'UTR	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	158							metal ion binding|protein binding			ovary(1)	1						GGCAGCGGCTGCAGCGGCCAG	0.587			NA											21	15					1.22574e-08	2.64831e-08	0.002299	1	0
LPAR4	2846	broad.mit.edu	37	X	78011031	78011031	+	Missense_Mutation	SNP	C	C	G			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chrX:78011031C>G	uc010nme.2	+	2	1070	c.665C>G	c.(664-666)TCT>TGT	p.S222C		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	222	Helical; Name=5; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TTGAATGTCTCTTGCTCTTCT	0.373			NA											8	18					0	0	0.00308	0	0
F5	2153	broad.mit.edu	37	1	169529792	169529793	+	Frame_Shift_Ins	INS	-	-	T			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr1:169529792_169529793insT	uc001ggg.1	-	4	730_731	c.585_586insA	c.(583-588)AAAGGGfs	p.K195fs	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	195_196	F5/8 type A 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTGTTCTTACCTTTTTTACAGA	0.446			NA											11	55	---	---	---	---	NA	NA	NA	NA	NA
FAM21C	253725	broad.mit.edu	37	10	46250511	46250513	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	TGA	TGA	-	-	TGA	TGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr10:46250511_46250513delTGA	uc001jcu.2	+	15	1467_1469	c.1368_1370delTGA	c.(1366-1371)GGTGAT>GGT	p.D461del	FAM21C_uc001jcs.1_In_Frame_Del_p.D406del|FAM21C_uc001jct.2_In_Frame_Del_p.D461del|FAM21C_uc010qfi.1_In_Frame_Del_p.D437del|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'Flank	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	461										ovary(1)	1						atgatgatggtgatgatgatgac	0.448			NA											7	22	---	---	---	---	NA	NA	NA	NA	NA
HSP90AA1	3320	broad.mit.edu	37	14	102552609	102552616	+	Frame_Shift_Del	DEL	GTATTGAT	GTATTGAT	-			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	GTATTGAT	GTATTGAT	-	-	GTATTGAT	GTATTGAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr14:102552609_102552616delGTATTGAT	uc001yku.3	-	2	290_297	c.100_107delATCAATAC	c.(100-108)ATCAATACTfs	p.I34fs	HSP90AA1_uc001ykv.3_Frame_Shift_Del_p.I156fs|HSP90AA1_uc001ykw.1_5'UTR|HSP90AA1_uc001ykx.1_Frame_Shift_Del_p.I23fs	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	34_36					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CGAGTAGAAAGTATTGATGATCAATGAC	0.438			NA											8	65	---	---	---	---	NA	NA	NA	NA	NA
GIPC1	10755	broad.mit.edu	37	19	14589262	14589262	+	Frame_Shift_Del	DEL	C	C	-			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:14589262delC	uc002myt.2	-	9	1238	c.968delG	c.(967-969)GGCfs	p.G323fs	GIPC1_uc002myu.2_Frame_Shift_Del_p.G323fs|GIPC1_uc002myv.2_Frame_Shift_Del_p.G226fs|GIPC1_uc002myw.2_Frame_Shift_Del_p.G226fs|GIPC1_uc002myx.2_Frame_Shift_Del_p.G323fs|GIPC1_uc002myy.2_Frame_Shift_Del_p.G226fs	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	323					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						CCCAATGGCGCCCCAGACGTC	0.657	Pancreas(33;78 923 2910 41023 52850)		NA											3	6	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	19	34583921	34583921	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr19:34583921delG	uc002nuz.2	-	1	293	c.241delC	c.(241-243)CGTfs	p.R81fs						full-length cDNA clone CS0DE007YF24 of Placenta of Homo sapiens (human).												NA						TAGATCAGACGGAAACCCTCT	0.428			NA											5	8	---	---	---	---	NA	NA	NA	NA	NA
FIGN	55137	broad.mit.edu	37	2	164467519	164467519	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr2:164467519delG	uc002uck.1	-	3	1134	c.823delC	c.(823-825)CTGfs	p.L275fs		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	275	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CCTGAAGGCAGGTACGCTGAA	0.617			NA											12	42	---	---	---	---	NA	NA	NA	NA	NA
ABHD5	51099	broad.mit.edu	37	3	43732525	43732526	+	Frame_Shift_Del	DEL	GA	GA	-	rs138695912		TCGA-91-6840-01A-11D-1945-08	TCGA-91-6840-10A-01D-1946-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	09bc8542-4ea1-4599-91b3-d606425b37e2	087d5121-0e86-4be5-9e53-11efd5184752	g.chr3:43732525_43732526delGA	uc003cmx.2	+	1	151_152	c.41_42delGA	c.(40-42)GGAfs	p.G14fs		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	14					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		GCCGACACCGGAGAGAGGTAAG	0.733			NA											8	25	---	---	---	---	NA	NA	NA	NA	NA
