Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MORN1	79906	broad.mit.edu	37	1	2288985	2288985	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:2288985C>T	uc001ajb.1	-	10	943	c.922G>A	c.(922-924)GGG>AGG	p.G308R	MORN1_uc009vld.2_Missense_Mutation_p.G284R|MORN1_uc001ajd.1_Missense_Mutation_p.G308R	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	308										ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GCTCTGGGCCCCGGCACCCCA	0.652			NA											32	97					0	0	0.002836	0	0
MEGF6	1953	broad.mit.edu	37	1	3427376	3427376	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:3427376C>A	uc001akl.2	-	10	1432	c.1205G>T	c.(1204-1206)CGG>CTG	p.R402L	MEGF6_uc001akk.2_Missense_Mutation_p.R297L	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	402	EGF-like 7.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GGCACTGAGCCGGTAGCCGGC	0.672	Ovarian(73;978 3658)		NA											23	48					1.66031e-10	2.44718e-10	0.003954	1	0
KIAA0562	9731	broad.mit.edu	37	1	3740027	3740027	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:3740027C>A	uc001aky.2	-	19	2823	c.2464G>T	c.(2464-2466)GAA>TAA	p.E822*	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	822						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		GGCAGCTCTTCCTTGAAAACA	0.542			NA											32	95					4.74835e-14	7.65149e-14	0.010818	1	0
MTOR	2475	broad.mit.edu	37	1	11182094	11182094	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:11182094C>T	uc001asd.2	-	48	6873	c.6752G>A	c.(6751-6753)CGG>CAG	p.R2251Q	MTOR_uc001asc.2_Missense_Mutation_p.R456Q	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2251	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCTGTAGTCCCGGATGAGGGC	0.577			NA											14	79					0	0	0.003163	0	0
AADACL4	343066	broad.mit.edu	37	1	12711243	12711243	+	Silent	SNP	C	C	A	rs140616597		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:12711243C>A	uc001auf.2	+	2	270	c.270C>A	c.(268-270)ACC>ACA	p.T90T		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	90	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TTGTGGTGACCGACCTGCGTT	0.502			NA											27	42					2.79863e-10	4.09588e-10	0.004656	1	0
PRDM2	7799	broad.mit.edu	37	1	14107117	14107117	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:14107117G>T	uc001avi.2	+	8	3683	c.2827G>T	c.(2827-2829)GAT>TAT	p.D943Y	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.D943Y|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.D742Y|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	943	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTCCACACCTGATGTTTGTCC	0.582			NA											60	154					1.83847e-13	2.93966e-13	0.00361	1	0
ALDH4A1	8659	broad.mit.edu	37	1	19209835	19209835	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:19209835C>A	uc001bbb.2	-	6	817	c.541G>T	c.(541-543)GAG>TAG	p.E181*	ALDH4A1_uc010ocu.1_Nonsense_Mutation_p.E121*|ALDH4A1_uc001bbc.2_Nonsense_Mutation_p.E181*	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	181					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TGCTGCCCCTCCAGCTCCACC	0.637			NA											21	30					6.33239e-15	1.042e-14	0.010504	1	0
KIAA0090	23065	broad.mit.edu	37	1	19549300	19549300	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:19549300C>T	uc001bbo.2	-	20	2448	c.2405G>A	c.(2404-2406)CGC>CAC	p.R802H	KIAA0090_uc001bbn.2_5'Flank|KIAA0090_uc001bbp.2_Missense_Mutation_p.R801H|KIAA0090_uc001bbq.2_Missense_Mutation_p.R801H|KIAA0090_uc001bbr.2_Missense_Mutation_p.R780H	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	802	DUF1620.|Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		AAACTCGTTGCGCCGAGCCTT	0.592	GBM(4;72 124 25802 30195)		NA											4	38					0	0	0.009096	0	0
NIPAL3	57185	broad.mit.edu	37	1	24768625	24768626	+	Silent	DNP	CC	CC	TT			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:24768625_24768626CC>TT	uc001bjh.2	+	4	650_651	c.243_244CC>TT	c.(241-246)TTCCTG>TTTTTG	p.81_82FL>FL	NIPAL3_uc010oek.1_Silent_p.81_82FL>FL|NIPAL3_uc001bjg.2_Silent_p.81_82FL>FL|NIPAL3_uc009vrc.2_5'UTR	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	81_82	Helical; (Potential).					integral to membrane					0						TGGGCCTGTTCCTGATGCTTCT	0.574			NA											31	80					0	0	0.004672	0	0
CATSPER4	378807	broad.mit.edu	37	1	26517187	26517187	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:26517187G>T	uc010oez.1	+	1	69	c.69G>T	c.(67-69)GGG>GGT	p.G23G	CATSPER4_uc010oey.1_5'UTR|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	23	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGGGGCGGGACTCAGGAGG	0.597			NA											11	33					2.27111e-07	2.96771e-07	0.001368	1	0
GJB4	127534	broad.mit.edu	37	1	35227283	35227283	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:35227283C>A	uc001bxv.1	+	2	798	c.428C>A	c.(427-429)GCT>GAT	p.A143D	GJB4_uc001bxw.3_Missense_Mutation_p.A143D	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	143	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GCCGTGGATGCTGGCTTCCTC	0.607			NA											17	44					2.48551e-13	3.94384e-13	0.00499	1	0
RAD54L	8438	broad.mit.edu	37	1	46726526	46726526	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:46726526G>C	uc009vye.2	+	8	719	c.605G>C	c.(604-606)CGC>CCC	p.R202P	RAD54L_uc001cpl.2_Missense_Mutation_p.R202P|RAD54L_uc001cpm.1_Missense_Mutation_p.R22P	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	202	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		ACACTTTTACGCCAGAGTCCA	0.547			NA						Direct_reversal_of_damage|Homologous_recombination					9	37					0	0	0.004482	0	0
LRRC7	57554	broad.mit.edu	37	1	70504765	70504765	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:70504765A>G	uc001dep.2	+	19	3174	c.3144A>G	c.(3142-3144)ATA>ATG	p.I1048M	LRRC7_uc009wbg.2_Missense_Mutation_p.I332M|LRRC7_uc001deq.2_Missense_Mutation_p.I289M	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1048						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AAAAGAGGATACCACCCCCTT	0.448			NA											8	31					0	0	0.008291	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510025	77510025	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:77510025G>T	uc001dhi.2	+	3	573	c.398G>T	c.(397-399)CGT>CTT	p.R133L	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	133	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						GGCTATGGGCGTGACGTGGGC	0.622			NA											26	59					3.73808e-20	6.75897e-20	0.005443	1	0
PRKACB	5567	broad.mit.edu	37	1	84679969	84679969	+	Missense_Mutation	SNP	C	C	T	rs143624941	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:84679969C>T	uc001djj.2	+	9	1163	c.899C>T	c.(898-900)ACG>ATG	p.T300M	PRKACB_uc001djl.2_Missense_Mutation_p.T347M|PRKACB_uc010ort.1_Missense_Mutation_p.T307M|PRKACB_uc001djn.2_Missense_Mutation_p.T304M|PRKACB_uc010oru.1_Missense_Mutation_p.T288M|PRKACB_uc001djp.2_Missense_Mutation_p.T306M|PRKACB_uc001djq.2_Missense_Mutation_p.T270M|PRKACB_uc010orv.1_Missense_Mutation_p.T287M	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	300	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TGGTTTGCCACGACAGATTGG	0.363			NA											4	24					0	0	0.000602	0	0
WDR63	126820	broad.mit.edu	37	1	85547055	85547055	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:85547055G>T	uc001dkt.2	+	4	433	c.242G>T	c.(241-243)AGA>ATA	p.R81I	WDR63_uc009wcl.2_Missense_Mutation_p.R81I	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	81										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CTGCGCAACAGAGCTGCAGTA	0.378			NA											9	36					1.12685e-05	1.36628e-05	0.004482	1	0
GLMN	11146	broad.mit.edu	37	1	92733549	92733549	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:92733549T>A	uc001dor.2	-	11	1134	c.1019A>T	c.(1018-1020)GAG>GTG	p.E340V	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Missense_Mutation_p.E340V	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	340					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TAAACTATTCTCCAGCAGCTC	0.294			NA							Multiple_Glomus_Tumors_(of_the_Skin)_Familial				15	67					0	0	0.00245	0	0
LPPR4	9890	broad.mit.edu	37	1	99771914	99771914	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:99771914C>A	uc001dse.2	+	7	1746	c.1640C>A	c.(1639-1641)TCC>TAC	p.S547Y	LPPR4_uc010oue.1_Missense_Mutation_p.S489Y	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	547							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ATAAGCACCTCCCCCAAAAGC	0.537			NA											42	104					1.57019e-19	2.79845e-19	0.007835	1	0
COL11A1	1301	broad.mit.edu	37	1	103449739	103449739	+	Silent	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:103449739A>T	uc001dul.2	-	31	2829	c.2511T>A	c.(2509-2511)CTT>CTA	p.L837L	COL11A1_uc001duk.2_Nonsense_Mutation_p.L28*|COL11A1_uc001dum.2_Silent_p.L849L|COL11A1_uc001dun.2_Silent_p.L798L|COL11A1_uc009weh.2_Silent_p.L721L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	837	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGAACTCCAAGTTTTCCCT	0.214			NA											7	8					0	0	0.001984	0	0
VANGL1	81839	broad.mit.edu	37	1	116206606	116206606	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:116206606G>C	uc001efv.1	+	4	800	c.529G>C	c.(529-531)GCT>CCT	p.A177P	VANGL1_uc009wgy.1_Missense_Mutation_p.A175P|VANGL1_uc001efw.1_Missense_Mutation_p.A177P	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	177	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CAAGCGGAGAGCTGACATGCC	0.488			NA											22	129					0	0	0.00278	0	0
MTMR11	10903	broad.mit.edu	37	1	149907245	149907245	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:149907245G>C	uc001etl.3	-	4	523	c.272C>G	c.(271-273)CCC>CGC	p.P91R	MTMR11_uc001etm.1_Missense_Mutation_p.P19R|MTMR11_uc010pbm.1_Missense_Mutation_p.P63R|MTMR11_uc010pbn.1_5'Flank|MTMR11_uc010pbo.1_RNA	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	91							phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACTGTTCAAGGGAGTGTCCTA	0.532			NA											26	28					0	0	0.00632	0	0
LCE2D	353141	broad.mit.edu	37	1	152636902	152636902	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:152636902G>T	uc001fag.2	+	2	376	c.321G>T	c.(319-321)GGG>GGT	p.G107G		NM_178430	NP_848517	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	107	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACAGCTCTGGGGGCTGCTGCT	0.592			NA											24	145					2.21704e-12	3.42183e-12	0.00278	1	0
TDRD10	126668	broad.mit.edu	37	1	154519884	154519884	+	Splice_Site	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:154519884G>C	uc009wow.2	+	12	1791	c.953_splice	c.e12-1	p.D318_splice	TDRD10_uc001ffd.2_Splice_Site_p.D318_splice|TDRD10_uc001ffe.2_Splice_Site_p.D239_splice	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a								nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TTGTTTTGCAGACATTTTGAG	0.512			NA											10	79					0	0	0.008291	0	0
INSRR	3645	broad.mit.edu	37	1	156811916	156811916	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:156811916C>A	uc010pht.1	-	19	3639	c.3385G>T	c.(3385-3387)GTC>TTC	p.V1129F	NTRK1_uc001fqf.1_Missense_Mutation_p.T18K|NTRK1_uc009wsi.1_5'UTR	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	1129	Cytoplasmic (Potential).|Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGATCTTGACGGTGAAGTCC	0.443			NA											8	55					3.09899e-07	3.99083e-07	0.004482	1	0
PEAR1	375033	broad.mit.edu	37	1	156876502	156876502	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:156876502C>A	uc001fqj.1	+	6	590	c.474C>A	c.(472-474)CCC>CCA	p.P158P	PEAR1_uc009wsl.1_Silent_p.P20P|PEAR1_uc001fqk.1_5'UTR	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	158						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CGTGTGATCCCAAGAGTGGGG	0.627			NA											68	69					2.92363e-43	5.57822e-43	0.00361	1	0
PYHIN1	149628	broad.mit.edu	37	1	158913591	158913591	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:158913591T>C	uc001ftb.2	+	6	1259	c.1014T>C	c.(1012-1014)AAT>AAC	p.N338N	PYHIN1_uc001ftc.2_Silent_p.N329N|PYHIN1_uc001ftd.2_Silent_p.N338N|PYHIN1_uc001fte.2_Silent_p.N329N	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	338	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					AAATTGTAAATAGGAAGACGA	0.343			NA											11	23					0	0	0.010729	0	0
SLAMF9	89886	broad.mit.edu	37	1	159923135	159923135	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:159923135T>C	uc001fus.2	-	2	472	c.355A>G	c.(355-357)ATC>GTC	p.I119V	SLAMF9_uc009wtd.2_Missense_Mutation_p.I119V|SLAMF9_uc001fut.2_Intron	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	119	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGGTAGAGATCTGGGATGTT	0.498			NA											61	63					0	0	0.00361	0	0
SLAMF1	6504	broad.mit.edu	37	1	160616670	160616670	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:160616670G>C	uc001fwl.3	-	1	412	c.66C>G	c.(64-66)AGC>AGG	p.S22R	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_RNA|SLAMF1_uc001fwm.2_Missense_Mutation_p.S22R	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	22	Extracellular (Potential).				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTGTTCCGTAGCTTGCCCCAA	0.557			NA											6	42					0	0	0.001168	0	0
PVRL4	81607	broad.mit.edu	37	1	161049471	161049471	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:161049471G>A	uc001fxo.2	-	2	647	c.348C>T	c.(346-348)AAC>AAT	p.N116N		NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	116	Ig-like V-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCTGCACTGCGTTGCGCAGGA	0.701	NSCLC(76;1160 1387 14476 16172 29359)		NA											7	51					0	0	0.001984	0	0
SLC9A11	284525	broad.mit.edu	37	1	173569280	173569280	+	Silent	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:173569280T>A	uc001giz.2	-	3	627	c.204A>T	c.(202-204)GGA>GGT	p.G68G	SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	68	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						AGGCCATGTGTCCTATCACGA	0.313			NA											30	30					0	0	0.004289	0	0
CACNA1E	777	broad.mit.edu	37	1	181479632	181479632	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:181479632C>A	uc001gow.2	+	2	451	c.286C>A	c.(286-288)CTG>ATG	p.L96M	CACNA1E_uc009wxr.2_Missense_Mutation_p.L3M|CACNA1E_uc009wxs.2_Missense_Mutation_p.L3M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	96	I.|Helical; Name=S1 of repeat I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GTACATGATCCTGGCCACCAT	0.537			NA											5	37					0.000602214	0.000670085	0.000602	1	0
NCF2	4688	broad.mit.edu	37	1	183536055	183536055	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:183536055C>A	uc001gqj.3	-	9	1199	c.924G>T	c.(922-924)CAG>CAT	p.Q308H	NCF2_uc010pod.1_Missense_Mutation_p.Q263H|NCF2_uc010poe.1_Missense_Mutation_p.Q227H|NCF2_uc001gqk.3_Missense_Mutation_p.Q308H	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	308					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						ATCACATTACCTGGGGCTGCT	0.542			NA											32	45					3.62531e-18	6.28117e-18	0.004289	1	0
TPR	7175	broad.mit.edu	37	1	186324788	186324788	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:186324788C>A	uc001grv.2	-	16	2298	c.2001G>T	c.(1999-2001)GAG>GAT	p.E667D		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	667	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CAGCCTTAGCCTCTATAGCCT	0.413			NA	T	NTRK1	papillary thyroid								15	88					1.3612e-06	1.72438e-06	0.003163	1	0
F13B	2165	broad.mit.edu	37	1	197026449	197026449	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:197026449C>T	uc001gtt.1	-	6	996	c.952G>A	c.(952-954)GAT>AAT	p.D318N		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	318	Sushi 5.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CATTTTCCATCTTCACAACGT	0.358			NA											12	92					0	0	0.010729	0	0
NFASC	23114	broad.mit.edu	37	1	204985633	204985633	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:204985633C>T	uc001hbj.2	+	30	4017	c.3689C>T	c.(3688-3690)ACG>ATG	p.T1230M	NFASC_uc010pra.1_Missense_Mutation_p.T1164M|NFASC_uc001hbi.2_Missense_Mutation_p.T1159M|NFASC_uc010prb.1_Missense_Mutation_p.T1179M|NFASC_uc010prc.1_Missense_Mutation_p.T730M|NFASC_uc001hbl.1_Missense_Mutation_p.T306M|NFASC_uc001hbm.1_Missense_Mutation_p.T253M|NFASC_uc009xbh.1_Missense_Mutation_p.R85C|NFASC_uc001hbo.1_Missense_Mutation_p.R106C	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1337	Cytoplasmic (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCAGAGGCCACGTCACCTGTC	0.562			NA											35	47					0	0	0.003755	0	0
TRAF5	7188	broad.mit.edu	37	1	211534059	211534059	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:211534059T>C	uc001hih.2	+	6	619	c.559T>C	c.(559-561)TTG>CTG	p.L187L	TRAF5_uc001hii.2_Silent_p.L187L|TRAF5_uc010psx.1_Silent_p.L198L|TRAF5_uc010psy.1_Intron|TRAF5_uc001hij.2_Silent_p.L187L	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	187	TRAF-type 2.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TGAGGAAAACTTGTGTCCTGA	0.368			NA											7	43					0	0	0.00308	0	0
TMEM206	55248	broad.mit.edu	37	1	212553283	212553283	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:212553283C>T	uc001hjc.3	-	5	760	c.592G>A	c.(592-594)GCC>ACC	p.A198T	TMEM206_uc010pte.1_Missense_Mutation_p.A259T	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	198	Extracellular (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		TAATCAATGGCGCTGAAGTCC	0.502			NA											9	96					0	0	0.006214	0	0
PTPN14	5784	broad.mit.edu	37	1	214575100	214575100	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:214575100T>C	uc001hkk.1	-	7	868	c.597A>G	c.(595-597)GCA>GCG	p.A199A	PTPN14_uc010pty.1_Silent_p.A100A	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	199	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GTTCAGCTTCTGCTGGCAGGA	0.443	Colon(92;557 1424 24372 34121 40073)		NA											65	60					0	0	0.00361	0	0
USH2A	7399	broad.mit.edu	37	1	216420066	216420067	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:216420066_216420067GG>TT	uc001hku.1	-	13	3056_3057	c.2669_2670CC>AA	c.(2668-2670)ACC>AAA	p.T890K	USH2A_uc001hkv.2_Missense_Mutation_p.T890K	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	890	Laminin EGF-like 7.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AATTGTCAATGGTCAAATTGTA	0.475			NA								HNSCC(13;0.011)			22	200					0	0	0.004672	0	0
FBXO28	23219	broad.mit.edu	37	1	224318265	224318265	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:224318265T>G	uc001hoh.2	+	2	400	c.359T>G	c.(358-360)GTT>GGT	p.V120G	FBXO28_uc009xef.2_Missense_Mutation_p.V120G|FBXO28_uc010pvc.1_5'UTR	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	120										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		CAGAAACAAGTTAAAGCACAA	0.393			NA											23	24					0	0	0.012319	0	0
NID1	4811	broad.mit.edu	37	1	236175324	236175324	+	Silent	SNP	T	T	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:236175324T>G	uc001hxo.2	-	12	2526	c.2424A>C	c.(2422-2424)CCA>CCC	p.P808P	NID1_uc009xgd.2_Intron|NID1_uc009xgc.2_5'UTR	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	808	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GACATCGGCTTGGCTGGCATT	0.507			NA											4	66					0	0	0.001168	0	0
ACTN2	88	broad.mit.edu	37	1	236881227	236881227	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:236881227T>A	uc001hyf.2	+	2	400	c.196T>A	c.(196-198)TTC>ATC	p.F66I	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Missense_Mutation_p.F66I	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	66	CH 1.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGAGGAAGACTTCAGGAATGG	0.463			NA											24	27					0	0	0.00333	0	0
RYR2	6262	broad.mit.edu	37	1	237729937	237729937	+	Silent	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:237729937A>T	uc001hyl.1	+	28	3405	c.3285A>T	c.(3283-3285)GCA>GCT	p.A1095A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1095	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGACCTATGCAGTGAAGGCCG	0.557			NA											77	79					0	0	0.00361	0	0
RYR2	6262	broad.mit.edu	37	1	237813181	237813181	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:237813181C>T	uc001hyl.1	+	50	7637	c.7517C>T	c.(7516-7518)GCT>GTT	p.A2506V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2506	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTCAGGCAGCTTTGAGTGCT	0.458			NA											24	120					0	0	0.00333	0	0
RYR2	6262	broad.mit.edu	37	1	237947313	237947313	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:237947313C>A	uc001hyl.1	+	90	12421	c.12301C>A	c.(12301-12303)CTT>ATT	p.L4101I	RYR2_uc010pya.1_Missense_Mutation_p.L516I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4101					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGTCGCCGTCCTTCTGACAAA	0.517			NA											19	22					2.94398e-08	3.98945e-08	0.007413	1	0
ZP4	57829	broad.mit.edu	37	1	238049109	238049109	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:238049109G>C	uc001hym.2	-	7	917	c.917C>G	c.(916-918)CCC>CGC	p.P306R	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	306	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CTCAGGAAAGGGTGGTGGGAG	0.502	NSCLC(166;160 2029 11600 18754 19936)		NA											42	38					0	0	0.006999	0	0
WDR64	128025	broad.mit.edu	37	1	241912881	241912881	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:241912881C>A	uc001hzf.1	+	8	910	c.757C>A	c.(757-759)CAG>AAG	p.Q253K	WDR64_uc001hzg.1_5'UTR	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	533	WD 7.									skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TGGCAGTGGGCAGGAGATGAA	0.493			NA											35	62					3.62531e-18	6.28117e-18	0.004289	1	0
PLD5	200150	broad.mit.edu	37	1	242511458	242511458	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:242511458C>T	uc001hzn.1	-	2	403	c.276G>A	c.(274-276)ATG>ATA	p.M92I	PLD5_uc001hzl.3_Missense_Mutation_p.M30I|PLD5_uc001hzm.3_5'UTR|PLD5_uc001hzo.1_5'UTR			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	92						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CATCCTCTCCCATGATGTCCA	0.458			NA											47	67					0	0	0.00361	0	0
OR2W3	343171	broad.mit.edu	37	1	248059128	248059128	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:248059128G>A	uc001idp.1	+	3	509	c.240G>A	c.(238-240)CAG>CAA	p.Q80Q	OR2W3_uc010pzb.1_Silent_p.Q80Q	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCATCCCCCAGCTGCTCTACA	0.587			NA											29	174					0	0	0.00632	0	0
OR2L1P	26247	broad.mit.edu	37	1	248154045	248154045	+	Missense_Mutation	SNP	C	C	T	rs115826103	by1000genomes	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:248154045C>T	uc001idv.1	+	1	477	c.233C>T	c.(232-234)ACG>ATG	p.T78M	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						TGTGCTCACACGGTATATGCA	0.463			NA											49	67					0	0	0.00361	0	0
OR2L2	26246	broad.mit.edu	37	1	248202247	248202247	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:248202247C>G	uc001idw.2	+	1	774	c.678C>G	c.(676-678)CGC>CGG	p.R226R	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTGTCTACCGCATGCACTCTG	0.483			NA											107	129					0	0	0.00361	0	0
OR2M5	127059	broad.mit.edu	37	1	248308862	248308862	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:248308862C>G	uc010pze.1	+	1	413	c.413C>G	c.(412-414)CCC>CGC	p.P138R		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTCATGAGACCCAAAATTTGT	0.458			NA											55	332					0	0	0.00361	0	0
OR14C36	127066	broad.mit.edu	37	1	248512288	248512288	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:248512288A>T	uc010pzl.1	+	1	212	c.212A>T	c.(211-213)TAC>TTC	p.Y71F		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GATGCCTGCTACATTTCTGTT	0.488			NA											31	146					0	0	0.009535	0	0
OR14I1	401994	broad.mit.edu	37	1	248844746	248844746	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:248844746A>T	uc001ieu.1	-	1	860	c.860T>A	c.(859-861)ATA>AAA	p.I287K		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGACTATATATGATGGGATT	0.388			NA											10	67					0	0	0.008291	0	0
AKR1C4	1109	broad.mit.edu	37	10	5258743	5258743	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:5258743G>A	uc001ihw.2	+	8	949	c.916G>A	c.(916-918)GTT>ATT	p.V306I		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	306					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	TTATCGATATGTTGTCATGGA	0.348			NA											3	12					0	0	0.004672	0	0
C10orf18	54906	broad.mit.edu	37	10	5791121	5791121	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:5791121G>C	uc001iij.2	+	15	6362	c.5737G>C	c.(5737-5739)GTC>CTC	p.V1913L	C10orf18_uc001iik.2_Missense_Mutation_p.V757L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1913										ovary(1)|central_nervous_system(1)	2						GCCGCCTTACGTCCAAATCCG	0.542			NA											12	30					0	0	0.010729	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553016	6553016	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:6553016C>T	uc001ijj.1	-	3	334	c.259G>A	c.(259-261)GTG>ATG	p.V87M	PRKCQ_uc009xim.1_Missense_Mutation_p.V87M|PRKCQ_uc001iji.1_Missense_Mutation_p.V120M|PRKCQ_uc009xin.1_Missense_Mutation_p.V51M|PRKCQ_uc010qax.1_Translation_Start_Site	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	87	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TAGAGCTCCACGGTGGTTTCA	0.483	Ovarian(50;572 1126 10530 25349 30594)		NA											21	104					0	0	0.00278	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506637	37506637	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:37506637A>T	uc001iza.1	+	33	3029	c.2930A>T	c.(2929-2931)CAA>CTA	p.Q977L		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1033	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ACTTTAAACCAAGAAGAAGAG	0.289			NA											9	28					0	0	0.006214	0	0
ANK3	288	broad.mit.edu	37	10	62149354	62149354	+	Translation_Start_Site	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:62149354C>A	uc001jky.2	-	1	135	c.-57G>T	c.(-59--55)GAGGA>GATGA		ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AGGTGATATCCTCAGGCACCT	0.413			NA											7	36					0.00198382	0.00216101	0.001984	1	0
CDH23	64072	broad.mit.edu	37	10	73558329	73558329	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:73558329T>A	uc001jrx.3	+	48	7425	c.7048T>A	c.(7048-7050)TCG>ACG	p.S2350T	CDH23_uc001jsg.3_Missense_Mutation_p.S110T|CDH23_uc001jsh.3_Missense_Mutation_p.S110T|CDH23_uc001jsi.3_Missense_Mutation_p.S110T	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2350	Cadherin 22.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGAGGACTCCTCGGCAGGTAG	0.597			NA											9	22					0	0	0.004482	0	0
DYDC1	143241	broad.mit.edu	37	10	82111703	82111703	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:82111703T>C	uc001kbx.2	-	4	368	c.203A>G	c.(202-204)CAG>CGG	p.Q68R	DYDC1_uc001kby.1_Missense_Mutation_p.Q68R|DYDC1_uc009xsr.1_Missense_Mutation_p.Q68R|DYDC2_uc001kbz.1_Intron|DYDC2_uc001kca.1_Intron	NM_138812	NP_620167	Q8WWB3	DYDC1_HUMAN	DPY30 domain containing 1	68											0			Colorectal(32;0.229)			CATCATTTCCTGCTCCATCAG	0.468			NA											31	96					0	0	0.005524	0	0
NRG3	10718	broad.mit.edu	37	10	84733574	84733574	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:84733574G>C	uc001kco.2	+	7	1342	c.1315G>C	c.(1315-1317)GCA>CCA	p.A439P	NRG3_uc010qlz.1_Missense_Mutation_p.A438P|NRG3_uc001kcp.2_Missense_Mutation_p.A218P|NRG3_uc001kcq.2_Missense_Mutation_p.A89P|NRG3_uc001kcr.2_Missense_Mutation_p.A89P	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	439	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TCCTGTGACTGCATTGGAGAA	0.483			NA											24	51					0	0	0.003954	0	0
GRID1	2894	broad.mit.edu	37	10	87628790	87628790	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:87628790C>A	uc001kdl.1	-	6	1029	c.928G>T	c.(928-930)GAA>TAA	p.E310*	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	310	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGGTAGCCTTCCTGGGGGTCG	0.577			NA								Multiple Myeloma(13;0.14)			25	54					1.1804e-14	1.92705e-14	0.003954	1	0
MYOF	26509	broad.mit.edu	37	10	95116586	95116586	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:95116586T>C	uc001kin.2	-	30	3263	c.3140A>G	c.(3139-3141)GAC>GGC	p.D1047G	MYOF_uc001kio.2_Missense_Mutation_p.D1034G|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1047	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GCCCTCTTGGTCTTGCAATTC	0.353			NA											9	23					0	0	0.008291	0	0
HPSE2	60495	broad.mit.edu	37	10	100481549	100481549	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:100481549A>G	uc001kpn.1	-	5	881	c.821T>C	c.(820-822)GTA>GCA	p.V274A	HPSE2_uc009xwc.1_Missense_Mutation_p.V264A|HPSE2_uc001kpo.1_Missense_Mutation_p.V206A|HPSE2_uc009xwd.1_Missense_Mutation_p.V152A	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	274					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GCTGCCATTTACTGCCCGGCC	0.468			NA											11	42					0	0	0.001368	0	0
C10orf26	54838	broad.mit.edu	37	10	104572996	104572996	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:104572996C>A	uc001kwe.3	+	4	1197	c.937C>A	c.(937-939)CCG>ACG	p.P313T	C10orf26_uc001kwf.3_Missense_Mutation_p.P334T|C10orf26_uc009xxg.1_Intron	NM_017787	NP_060257	Q9NX94	OPA1L_HUMAN	hypothetical protein LOC54838 isoform 2	313						integral to membrane				central_nervous_system(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;6.14e-09)|all cancers(201;1.66e-07)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GCCTGGGCACCCGCACCTGCC	0.662			NA											18	63					1.99824e-07	2.62216e-07	0.00499	1	0
PWWP2B	170394	broad.mit.edu	37	10	134219612	134219612	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:134219612G>T	uc001lll.3	+	2	1637	c.1608G>T	c.(1606-1608)ACG>ACT	p.T536T	PWWP2B_uc009ybe.2_Intron	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	536	PWWP.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		CTCCGACTACGTCGTTCTTGT	0.498			NA											35	54					7.11191e-15	1.16718e-14	0.002836	1	0
MTG1	92170	broad.mit.edu	37	10	135209744	135209744	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr10:135209744G>T	uc001lnd.2	+	3	359	c.255G>T	c.(253-255)ATG>ATT	p.M85I	MTG1_uc010qve.1_Missense_Mutation_p.M1I	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	85	GTP (By similarity).					mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		TCAACAAGATGGACTTGGCGG	0.498			NA											48	78					1.02687e-29	1.92383e-29	0.013114	1	0
MUC6	4588	broad.mit.edu	37	11	1025222	1025222	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:1025222C>T	uc001lsw.2	-	23	2996	c.2945G>A	c.(2944-2946)AGG>AAG	p.R982K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	982	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTCATGTGCCTGTTCCAGAT	0.657			NA											61	153					0	0	0.00361	0	0
BRSK2	9024	broad.mit.edu	37	11	1466580	1466580	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:1466580G>A	uc001lti.2	+	10	1255	c.869G>A	c.(868-870)CGC>CAC	p.R290H	BRSK2_uc009ycv.1_Missense_Mutation_p.R290H|BRSK2_uc001lth.1_Missense_Mutation_p.R290H|BRSK2_uc001ltj.2_Missense_Mutation_p.R290H|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Missense_Mutation_p.R290H|BRSK2_uc001ltm.2_Missense_Mutation_p.R336H|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	290					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GTGCAGATCCGCTCGCTGCCC	0.657			NA											6	48					0	0	0.001984	0	0
TNNT3	7140	broad.mit.edu	37	11	1955808	1955808	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:1955808C>A	uc001luu.3	+	13	725	c.513C>A	c.(511-513)GCC>GCA	p.A171A	TNNT3_uc001lun.2_Silent_p.A67A|TNNT3_uc001luw.3_Silent_p.A163A|TNNT3_uc001luo.3_Silent_p.A163A|TNNT3_uc001lup.3_Silent_p.A169A|TNNT3_uc001luq.3_Silent_p.A163A|TNNT3_uc001lur.2_Silent_p.A163A|TNNT3_uc010qxf.1_Silent_p.A169A|TNNT3_uc010qxg.1_Silent_p.A103A	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	182					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		AGCAGACAGCCCGGGAAATGA	0.587			NA											6	11					0.00116845	0.0012886	0.001168	1	0
OR51A4	401666	broad.mit.edu	37	11	4967808	4967809	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:4967808_4967809GG>TT	uc010qys.1	-	1	522_523	c.522_523CC>AA	c.(520-525)AACCAA>AAAAAA	p.174_175NQ>KK		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	174_175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGATAATTGGTTTTTCTTGC	0.416			NA											41	247					0	0	0.004672	0	0
OR51A4	401666	broad.mit.edu	37	11	4968008	4968009	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:4968008_4968009CC>AA	uc010qys.1	-	1	322_323	c.322_323GG>TT	c.(322-324)GGA>TTA	p.G108L		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TACTGAGAATCCATGAATGAAG	0.441			NA											35	336					0	0	0.004672	0	0
OR51B5	282763	broad.mit.edu	37	11	5364119	5364119	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:5364119G>A	uc001map.1	-	1	636	c.636C>T	c.(634-636)ATC>ATT	p.I212I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAGATGAAGATAATCAGAT	0.468			NA											13	108					0	0	0.001368	0	0
OR52N4	390072	broad.mit.edu	37	11	5776415	5776415	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:5776415G>C	uc001mbu.2	+	1	493	c.445G>C	c.(445-447)GCC>CCC	p.A149P	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		GGTTGGGACTGCCACCTTCCT	0.488			NA											44	107					0	0	0.009718	0	0
OR56A3	390083	broad.mit.edu	37	11	5968677	5968677	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:5968677C>A	uc010qzt.1	+	1	101	c.101C>A	c.(100-102)CCC>CAC	p.P34H		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTCCCTGCCCCTCAGCCTC	0.572			NA											62	71					3.76628e-20	6.79023e-20	0.00361	1	0
DCHS1	8642	broad.mit.edu	37	11	6648047	6648047	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:6648047C>A	uc001mem.1	-	14	6633	c.6223G>T	c.(6223-6225)GCT>TCT	p.A2075S		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2075	Cadherin 20.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGAATCGTAGCCTCACTGCTA	0.587			NA											5	34					3.59834e-05	4.22295e-05	0.001168	1	0
DCHS1	8642	broad.mit.edu	37	11	6662271	6662271	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:6662271G>T	uc001mem.1	-	2	984	c.574C>A	c.(574-576)CGG>AGG	p.R192R		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	192	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCTCCAGCCGGAAGGTCTCT	0.607			NA											37	80					8.73648e-17	1.48472e-16	0.004289	1	0
OR10A4	283297	broad.mit.edu	37	11	6898303	6898303	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:6898303G>T	uc010rat.1	+	1	425	c.425G>T	c.(424-426)TGT>TTT	p.C142F		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CACATATCCTGTGCCCAGCTG	0.572			NA											23	78					1.87028e-06	2.33597e-06	0.012319	1	0
CTR9	9646	broad.mit.edu	37	11	10791812	10791812	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:10791812A>G	uc001mja.2	+	17	2314	c.2165A>G	c.(2164-2166)TAT>TGT	p.Y722C		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	722	TPR 16.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTTGTACTCTATTTGGCCCGG	0.378			NA											11	59					0	0	0.010729	0	0
INSC	387755	broad.mit.edu	37	11	15267485	15267485	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:15267485T>C	uc001mly.2	+	13	1685	c.1639T>C	c.(1639-1641)TGC>CGC	p.C547R	INSC_uc001mlz.2_Missense_Mutation_p.C500R|INSC_uc001mma.2_3'UTR|INSC_uc010rcs.1_Missense_Mutation_p.C535R|INSC_uc001mmb.2_Missense_Mutation_p.C500R|INSC_uc001mmc.2_Missense_Mutation_p.C458R	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	547					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GGCTGGGGTCTGCCCTGAAGG	0.547			NA											26	102					0	0	0.003954	0	0
ABCC8	6833	broad.mit.edu	37	11	17419927	17419927	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:17419927G>A	uc001mnc.2	-	30	3838	c.3712C>T	c.(3712-3714)CTC>TTC	p.L1238F		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1238	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GTGAGGAAGAGGGAAGCAATG	0.552			NA											5	74					0	0	0.001984	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159074	18159075	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:18159074_18159075GG>TT	uc001mnu.2	+	3	686_687	c.325_326GG>TT	c.(325-327)GGC>TTC	p.G109F		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	109	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CTACTTTATAGGCCTAAGCATG	0.55			NA											35	160					0	0	0.004672	0	0
LDHA	3939	broad.mit.edu	37	11	18421090	18421090	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:18421090G>T	uc001mok.3	+	3	511	c.239G>T	c.(238-240)GGC>GTC	p.G80V	LDHA_uc010rdc.1_Missense_Mutation_p.G80V|LDHA_uc009yhn.2_Missense_Mutation_p.G80V|LDHA_uc009yho.2_Intron|LDHA_uc001mol.3_Missense_Mutation_p.G80V|LDHA_uc010rdd.1_Missense_Mutation_p.G109V	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	80					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	ATTGTCTCTGGCAAAGGTTGA	0.284			NA											11	55					3.07112e-06	3.79015e-06	0.010729	1	0
MRGPRX2	117194	broad.mit.edu	37	11	19077263	19077263	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:19077263C>A	uc001mph.2	-	2	775	c.687G>T	c.(685-687)GTG>GTT	p.V229V		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	229	Helical; Name=6; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						GGAACACCAGCACTGTGAGCA	0.532	GBM(198;1966 2199 4849 37227 49954)		NA											25	45					1.85244e-09	2.6427e-09	0.00333	1	0
SLC17A6	57084	broad.mit.edu	37	11	22397583	22397583	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:22397583G>T	uc001mqk.2	+	10	1643	c.1230G>T	c.(1228-1230)GGG>GGT	p.G410G		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	410	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ATACTAGAGGGGTAGCAATCT	0.373			NA											7	220					2.74318e-10	4.02419e-10	0.006214	1	0
ANO3	63982	broad.mit.edu	37	11	26463584	26463584	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:26463584C>A	uc001mqt.3	+	2	311	c.166C>A	c.(166-168)CTC>ATC	p.L56I	ANO3_uc010rdr.1_Missense_Mutation_p.L40I	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	56	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTCTACTTCCCTCTTCCAGTC	0.473			NA											47	159					7.77372e-23	1.42213e-22	0.00361	1	0
KCNA4	3739	broad.mit.edu	37	11	30034191	30034191	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:30034191C>A	uc001msk.2	-	2	1187	c.35G>T	c.(34-36)GGG>GTG	p.G12V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	12						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTGTTGCACCCTGAGCTCTC	0.562			NA											41	134					1.04594e-18	1.8326e-18	0.00623	1	0
DCDC1	341019	broad.mit.edu	37	11	31312234	31312234	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:31312234T>A	uc001msv.2	-	7	1122	c.920A>T	c.(919-921)GAT>GTT	p.D307V	DCDC1_uc001msu.1_Intron	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	307					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					CTCATGCCCATCCTGCCCCAT	0.343			NA											9	49					0	0	0.006214	0	0
C11orf41	25758	broad.mit.edu	37	11	33566805	33566805	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:33566805C>A	uc001mup.3	+	2	2517	c.2393C>A	c.(2392-2394)CCA>CAA	p.P798Q	C11orf41_uc001mun.1_Missense_Mutation_p.P798Q	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	792						integral to membrane				ovary(2)	2						CGGTTGCCACCATTGCGAGCA	0.582			NA											29	75					2.48779e-11	3.7377e-11	0.005443	1	0
TP53I11	9537	broad.mit.edu	37	11	44956479	44956479	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:44956479T>A	uc001myi.2	-	10	1131	c.526A>T	c.(526-528)ATT>TTT	p.I176F	TP53I11_uc001myf.1_Intron|TP53I11_uc001myj.2_Missense_Mutation_p.I176F|TP53I11_uc001myk.2_Missense_Mutation_p.I176F|TP53I11_uc001myl.2_Missense_Mutation_p.I176F|TP53I11_uc001mym.2_Missense_Mutation_p.I123F	NM_006034	NP_006025	O14683	P5I11_HUMAN	p53-induced protein	176	Helical; (Potential).				negative regulation of cell proliferation|response to stress	integral to membrane		p.I176M(1)		ovary(1)	1						TAGTAGTAAATGCTGATGACG	0.627			NA											26	67					0	0	0.00333	0	0
CHRM4	1132	broad.mit.edu	37	11	46406886	46406886	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:46406886C>A	uc001nct.1	-	1	1222	c.1222G>T	c.(1222-1224)GCC>TCC	p.A408S		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	408	Helical; Name=6; (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	AGGATGAAGGCTAGCAGAATG	0.597	Esophageal Squamous(171;1020 1936 4566 30205 42542)		NA											17	29					3.45872e-05	4.08997e-05	0.004007	1	0
OR4C46	119749	broad.mit.edu	37	11	51515557	51515557	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:51515557C>A	uc010ric.1	+	1	276	c.276C>A	c.(274-276)TTC>TTA	p.F92L		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCATCCTATTCAATGGATGCA	0.463			NA											52	122					1.51926e-22	2.77119e-22	0.00361	1	0
OR4C15	81309	broad.mit.edu	37	11	55322784	55322784	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:55322784G>T	uc010rig.1	+	1	1002	c.1002G>T	c.(1000-1002)TTG>TTT	p.L334F		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TAAATCCCTTGCTCAATCCTT	0.363			NA								HNSCC(20;0.049)			22	87					3.62473e-10	5.26772e-10	0.012319	1	0
OR5D14	219436	broad.mit.edu	37	11	55563449	55563449	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:55563449C>A	uc010rim.1	+	1	418	c.418C>A	c.(418-420)CAG>AAG	p.Q140K		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	140	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				GGCCATGTCACAGAGGCTCTG	0.537			NA											19	86					1.67942e-08	2.30087e-08	0.006122	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735071	55735071	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:55735071A>T	uc010rit.1	-	1	869	c.869T>A	c.(868-870)GTG>GAG	p.V290E		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	290	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TCTCAATGCCACCATGATATC	0.328			NA											7	37					0	0	0.006214	0	0
OR5J2	282775	broad.mit.edu	37	11	55944484	55944484	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:55944484C>A	uc010rjb.1	+	1	391	c.391C>A	c.(391-393)CTT>ATT	p.L131I		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GAGTCCCTTGCTTTACACTGT	0.453			NA											19	65					1.00905e-13	1.6176e-13	0.008871	1	0
OR6Q1	219952	broad.mit.edu	37	11	57798435	57798435	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:57798435A>T	uc010rjz.1	+	1	11	c.11A>T	c.(10-12)TAT>TTT	p.Y4F	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				ATGCAACCATATACCAAAAAC	0.448			NA											35	113					0	0	0.003271	0	0
SYT7	9066	broad.mit.edu	37	11	61295448	61295448	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:61295448C>T	uc001nrv.2	-	5	567	c.561G>A	c.(559-561)CTG>CTA	p.L187L	SYT7_uc009ynr.2_Silent_p.L262L	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	187	C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						CCTTGGTCTCCAGCTTGTGCT	0.582			NA											9	91					0	0	0.004482	0	0
ASRGL1	80150	broad.mit.edu	37	11	62123819	62123819	+	Silent	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:62123819A>G	uc001nte.3	+	3	497	c.213A>G	c.(211-213)ACA>ACG	p.T71T	ASRGL1_uc001ntf.3_Silent_p.T71T|ASRGL1_uc001ntg.3_Intron|ASRGL1_uc001nth.1_5'Flank	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	71					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	TCTTGAACACAAATGGTGAGG	0.328			NA											32	67					0	0	0.012213	0	0
SLC22A8	9376	broad.mit.edu	37	11	62782359	62782359	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:62782359C>A	uc001nwo.2	-	2	208	c.72G>T	c.(70-72)CTG>CTT	p.L24L	SLC22A8_uc001nwp.2_Silent_p.L24L|SLC22A8_uc009yom.2_Intron|SLC22A8_uc010rmm.1_Intron|SLC22A8_uc009yon.2_Silent_p.L24L	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	24	Helical; (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						TCGGGAGGCCCAGTATGGCTA	0.607			NA											5	170					3.59834e-05	4.22295e-05	0.001168	1	0
SART1	9092	broad.mit.edu	37	11	65733831	65733831	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:65733831G>T	uc001ogl.2	+	9	1084	c.992G>T	c.(991-993)CGC>CTC	p.R331L	SART1_uc010rot.1_Missense_Mutation_p.A217S	NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	331					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						CAAAAACCTCGCTCTATCCTG	0.607			NA											24	35					1.55469e-16	2.63493e-16	0.00333	1	0
ZDHHC24	254359	broad.mit.edu	37	11	66311271	66311271	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:66311271C>T	uc001oin.1	-	2	660	c.463G>A	c.(463-465)GTG>ATG	p.V155M	ACTN3_uc010rpi.1_5'Flank|ZDHHC24_uc001oim.1_RNA|ZDHHC24_uc009yrg.1_Missense_Mutation_p.V155M	NM_207340	NP_997223	Q6UX98	ZDH24_HUMAN	zinc finger, DHHC-type containing 24	155	Leu-rich.|Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding				0						CCCAGCAGCACAGAGACGTGG	0.692			NA									OREG0021110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	26					0	0	0.009096	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67059113	67059113	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:67059113G>T	uc001okc.1	+	6	687	c.176G>T	c.(175-177)CGC>CTC	p.R59L	ANKRD13D_uc001okd.1_Missense_Mutation_p.R146L|ANKRD13D_uc001oke.1_Missense_Mutation_p.R59L	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	59										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GATGTGTACCGCGTGTGGAAG	0.622			NA											22	57					1.10513e-12	1.72712e-12	0.002299	1	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293801	71293801	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:71293801C>G	uc001oqu.2	-	1	121	c.83G>C	c.(82-84)TGT>TCT	p.C28S		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	28						keratin filament					0						ACAGCCCCCACAGCCAGAGCC	0.647			NA											5	142					0	0	0.000602	0	0
TSKU	25987	broad.mit.edu	37	11	76506887	76506887	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:76506887C>T	uc001oxt.2	+	2	399	c.227C>T	c.(226-228)TCG>TTG	p.S76L		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	76	LRR 1.					extracellular region					0	Ovarian(111;0.112)					GTGAATGAGTCGGTGTTGGCG	0.637			NA											16	53					0	0	0.004007	0	0
CAPN5	726	broad.mit.edu	37	11	76833670	76833670	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:76833670C>A	uc001oxx.2	+	12	1837	c.1652C>A	c.(1651-1653)TCG>TAG	p.S551*	CAPN5_uc009yup.2_Nonsense_Mutation_p.S591*|CAPN5_uc009yuq.2_Nonsense_Mutation_p.S587*|CAPN5_uc001oxy.2_Nonsense_Mutation_p.S591*|CAPN5_uc001oya.2_Nonsense_Mutation_p.S113*	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	551	C2.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						AAAGTCCGCTCGGCTGTGCAG	0.453			NA											21	39					8.10497e-08	1.07951e-07	0.010504	1	0
PCF11	51585	broad.mit.edu	37	11	82868580	82868580	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:82868580C>A	uc001ozx.3	+	1	444	c.99C>A	c.(97-99)AGC>AGA	p.S33R	PCF11_uc010rsu.1_Missense_Mutation_p.S33R|PCF11_uc001ozy.2_Missense_Mutation_p.S33R	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	33	CID.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						CCTTCAATAGCAAGCCGCACA	0.587			NA											11	96					4.68919e-08	6.29952e-08	0.008291	1	0
KIAA1377	57562	broad.mit.edu	37	11	101833442	101833442	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:101833442A>G	uc001pgm.2	+	6	1946	c.1676A>G	c.(1675-1677)CAT>CGT	p.H559R	KIAA1377_uc001pgn.2_Missense_Mutation_p.H515R|KIAA1377_uc010run.1_Missense_Mutation_p.H360R|KIAA1377_uc009yxa.1_Missense_Mutation_p.H360R	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	559							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GTTGGCCAGCATAAGAAAATG	0.294			NA											10	26					0	0	0.006214	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103182692	103182692	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:103182692G>T	uc001pho.2	+	79	11723	c.11579G>T	c.(11578-11580)CGA>CTA	p.R3860L	DYNC2H1_uc001phn.1_Missense_Mutation_p.R3867L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3860	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity	p.R1300Q(3)			0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AATACACATCGAGCTCATGCT	0.358			NA											8	38					0.000274275	0.000308498	0.004482	1	0
ANKK1	255239	broad.mit.edu	37	11	113264300	113264300	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:113264300G>T	uc001pny.2	+	2	377	c.283G>T	c.(283-285)GGT>TGT	p.G95C		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	95	Protein kinase.						ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		GCAGCCCCTGGGTATTGTGAT	0.512			NA											10	33					7.48243e-07	9.55661e-07	0.006214	1	0
PVRL1	5818	broad.mit.edu	37	11	119548513	119548513	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:119548513C>A	uc001pwv.2	-	3	657	c.485G>T	c.(484-486)GGG>GTG	p.G162V	PVRL1_uc001pwu.1_Missense_Mutation_p.G162V|PVRL1_uc001pww.2_Missense_Mutation_p.G162V	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	162	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GTCATCCTGCCCCTTCTTGGC	0.562			NA											13	30					1.49906e-05	1.80003e-05	0.00245	1	0
ADAMTS15	170689	broad.mit.edu	37	11	130319110	130319110	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:130319110C>T	uc010scd.1	+	1	242	c.242C>T	c.(241-243)ACT>ATT	p.T81I		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	81					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GCCTTCTCCACTGAGCATCTG	0.597			NA											29	76					0	0	0.007291	0	0
A2M	2	broad.mit.edu	37	12	9230301	9230301	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:9230301A>G	uc001qvk.1	-	26	3385	c.3272T>C	c.(3271-3273)ATA>ACA	p.I1091T	A2M_uc001qvj.1_Missense_Mutation_p.I133T|A2M_uc009zgk.1_Missense_Mutation_p.I941T	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1091					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATTCACCTTTATGGCATTGTT	0.438			NA											12	60					0	0	0.00245	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21358833	21358833	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:21358833C>A	uc001req.3	+	11	1467	c.1363C>A	c.(1363-1365)CCA>ACA	p.P455T		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	455	Extracellular (Potential).|Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TAGAGATGTACCACTTTCTTA	0.299			NA											18	42					2.4624e-09	3.48093e-09	0.008871	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	20					3.09899e-07	3.99083e-07	0.004482	1	0
FAR2	55711	broad.mit.edu	37	12	29464033	29464033	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:29464033G>C	uc001ris.3	+	7	988	c.841G>C	c.(841-843)GTC>CTC	p.V281L	FAR2_uc001rit.2_Missense_Mutation_p.V281L|FAR2_uc009zjm.2_Missense_Mutation_p.V184L|uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	281					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						AGTTGATACAGTCGTCAATCT	0.438			NA											33	133					0	0	0.003271	0	0
ABCD2	225	broad.mit.edu	37	12	40013091	40013091	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:40013091C>A	uc001rmb.2	-	1	753	c.327G>T	c.(325-327)CTG>CTT	p.L109L		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	109	ABC transmembrane type-1.|Interaction with PEX19.|Helical; (Potential).				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CCACTGAGTGCAGGCAGAGCC	0.438			NA											13	47					0.00136819	0.00150356	0.001368	1	0
PRPF40B	25766	broad.mit.edu	37	12	50029645	50029645	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:50029645G>T	uc001rur.1	+	14	1293	c.1229G>T	c.(1228-1230)CGG>CTG	p.R410L	PRPF40B_uc001rup.1_Missense_Mutation_p.R432L|PRPF40B_uc001ruq.1_Missense_Mutation_p.R404L|PRPF40B_uc001rus.1_Missense_Mutation_p.R353L	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	410					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						AAGCAGCTCCGGCGCCGCAAT	0.597			NA											14	26					9.31168e-06	1.13566e-05	0.001855	1	0
OR6C3	254786	broad.mit.edu	37	12	55725826	55725826	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:55725826C>A	uc010spj.1	+	1	342	c.342C>A	c.(340-342)GCC>GCA	p.A114A		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTTTAACTGCCATGTCCTATG	0.423			NA											20	105					1.33834e-09	1.91367e-09	0.007413	1	0
GLS2	27165	broad.mit.edu	37	12	56867050	56867050	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:56867050G>T	uc001slj.2	-	14	1690	c.1411C>A	c.(1411-1413)CGG>AGG	p.R471R	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Silent_p.R206R|GLS2_uc009zot.2_Silent_p.R132R	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	471					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCTAACTTCCGAGCACAGTGC	0.363			NA											3	57					0.00909568	0.00963801	0.009096	1	0
SLC26A10	65012	broad.mit.edu	37	12	58018651	58018651	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:58018651C>G	uc001spe.2	+	10	1541	c.1230C>G	c.(1228-1230)CTC>CTG	p.L410L	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	410	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					CCTCTTAGCTCCTCCAGGTCC	0.587			NA											21	85					0	0	0.002299	0	0
TSPAN31	6302	broad.mit.edu	37	12	58139966	58139966	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:58139966T>A	uc001spt.2	+	3	393	c.239T>A	c.(238-240)ATC>AAC	p.I80N	TSPAN31_uc009zqb.2_Intron|TSPAN31_uc010ssa.1_Missense_Mutation_p.I2N	NM_005981	NP_005972	Q12999	TSN31_HUMAN	sarcoma amplified sequence	80	Helical; (Potential).				positive regulation of cell proliferation	integral to plasma membrane|membrane fraction					0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAGTACATGATCATCCTTGGT	0.373			NA											9	55					0	0	0.001368	0	0
SLC16A7	9194	broad.mit.edu	37	12	60168655	60168655	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:60168655C>G	uc001sqs.2	+	5	878	c.579C>G	c.(577-579)TCC>TCG	p.S193S	SLC16A7_uc001sqt.2_Silent_p.S193S|SLC16A7_uc001squ.2_Silent_p.S193S|SLC16A7_uc009zqi.2_Silent_p.S94S|SLC16A7_uc010ssi.1_Silent_p.S94S	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	193	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TGGCTGGTTCCCTCATGAGAC	0.408			NA											5	30					0	0	0.001168	0	0
LUM	4060	broad.mit.edu	37	12	91502264	91502264	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:91502264G>T	uc001tbm.2	-	2	882	c.493C>A	c.(493-495)CAT>AAT	p.H165N	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	165	LRR 5.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						TGCTGGAGATGGATGAAGGTC	0.453			NA											11	48					7.03913e-09	9.75131e-09	0.001368	1	0
TMCC3	57458	broad.mit.edu	37	12	94976286	94976286	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:94976286C>T	uc001tdj.2	-	2	225	c.107G>A	c.(106-108)AGC>AAC	p.S36N	TMCC3_uc001tdi.2_Missense_Mutation_p.S5N	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	36						integral to membrane				ovary(1)|skin(1)	2						CAGGGGCAGGCTTAAGGTATT	0.458			NA											12	59					0	0	0.001855	0	0
SLC5A8	160728	broad.mit.edu	37	12	101598296	101598296	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:101598296G>A	uc001thz.3	-	2	789	c.399C>T	c.(397-399)GTC>GTT	p.V133V		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	133	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CAATGAAGAGGACTGTTCCAC	0.333	GBM(60;420 1056 13605 22380 47675)		NA											11	21					0	0	0.010729	0	0
CUX2	23316	broad.mit.edu	37	12	111785481	111785481	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:111785481C>A	uc001tsa.1	+	22	3966	c.3813C>A	c.(3811-3813)ACC>ACA	p.T1271T		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1271						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						AGAAGCCAACCGTGAAGGAAC	0.617			NA											12	43					0.00010058	0.000115213	0.001368	1	0
DTX1	1840	broad.mit.edu	37	12	113534535	113534535	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:113534535A>T	uc001tuk.1	+	9	1990	c.1654A>T	c.(1654-1656)ATC>TTC	p.I552F		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	552					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GCGGCTGCTCATCACGGCCTG	0.652			NA											5	18					0	0	0.000602	0	0
RBM19	9904	broad.mit.edu	37	12	114386693	114386693	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:114386693C>A	uc009zwi.2	-	10	1365	c.1221G>T	c.(1219-1221)CGG>CGT	p.R407R	RBM19_uc001tvn.3_Silent_p.R407R|RBM19_uc001tvm.2_Silent_p.R407R	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	407	RRM 3.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					AGGGCAGGTTCCGTACAAAGA	0.592			NA											25	58					3.01185e-09	4.23839e-09	0.003954	1	0
CIT	11113	broad.mit.edu	37	12	120135562	120135562	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr12:120135562C>T	uc001txi.1	-	45	5711	c.5658G>A	c.(5656-5658)GCG>GCA	p.A1886A	CIT_uc001txh.1_Silent_p.A1405A|CIT_uc001txj.1_Silent_p.A1928A	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1886					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGTATGAGGACGCCAAGTAAA	0.602			NA											32	105					0	0	0.010818	0	0
NUPL1	9818	broad.mit.edu	37	13	25899149	25899149	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr13:25899149C>T	uc001uqi.2	+	10	1220	c.974C>T	c.(973-975)GCT>GTT	p.A325V	NUPL1_uc001uqg.1_Missense_Mutation_p.A325V|NUPL1_uc001uqj.2_Missense_Mutation_p.A313V	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	325	14 X 2 AA repeats of F-G.|Potential.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		GCTGAAATAGCTTTAAGAACC	0.328	Pancreas(166;1040 2004 4560 4728 37041)|GBM(109;1045 1520 7614 9308 19618)		NA											4	45					0	0	0.000602	0	0
WASF3	10810	broad.mit.edu	37	13	27259977	27259977	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr13:27259977G>A	uc001uqv.2	+	10	1729	c.1504G>A	c.(1504-1506)GAC>AAC	p.D502N	WASF3_uc001uqw.2_Missense_Mutation_p.D499N	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	502					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CGACTGGTCCGACTGAGCAAA	0.572			NA											6	32					0	0	0.004482	0	0
FLT1	2321	broad.mit.edu	37	13	28882994	28882994	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr13:28882994T>A	uc001usb.3	-	28	3991	c.3706A>T	c.(3706-3708)ACC>TCC	p.T1236S	FLT1_uc010aap.2_Missense_Mutation_p.T241S|FLT1_uc010aaq.2_Missense_Mutation_p.T361S|FLT1_uc001usa.3_Missense_Mutation_p.T454S	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1236	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AACATGGAGGTGGCATTCGGT	0.403			NA											5	17					0	0	0.001168	0	0
BRCA2	675	broad.mit.edu	37	13	32907344	32907344	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr13:32907344G>T	uc001uub.1	+	10	1956	c.1729G>T	c.(1729-1731)GCA>TCA	p.A577S	BRCA2_uc001uua.1_Missense_Mutation_p.A454S	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	577					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TTTGAAGAATGCAGGTTTAAT	0.338	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			9	45					3.09899e-07	3.99083e-07	0.004482	1	0
POSTN	10631	broad.mit.edu	37	13	38166303	38166303	+	Splice_Site	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr13:38166303T>A	uc001uwo.3	-	3	337	c.219_splice	c.e3-1	p.T73_splice	POSTN_uc001uwp.3_Splice_Site_p.T73_splice|POSTN_uc001uwr.2_Splice_Site_p.T73_splice|POSTN_uc001uwq.2_Splice_Site_p.T73_splice|POSTN_uc010teu.1_Splice_Site_p.T73_splice|POSTN_uc010tev.1_Splice_Site_p.T73_splice|POSTN_uc010tew.1_Splice_Site_p.T73_splice|POSTN_uc010tex.1_Splice_Site	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AACACAGTCCTGTACATAGGA	0.289			NA											7	18					0	0	0.001984	0	0
RASA3	22821	broad.mit.edu	37	13	114781695	114781695	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr13:114781695C>A	uc001vui.2	-	13	1390	c.1259G>T	c.(1258-1260)GGA>GTA	p.G420V	RASA3_uc010tkk.1_Missense_Mutation_p.G388V|RASA3_uc001vuj.2_Missense_Mutation_p.G37V	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	420	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			AAGGTTTTCTCCGTCTTTCAA	0.507			NA											11	30					3.86212e-05	4.51549e-05	0.008291	1	0
CEBPE	1053	broad.mit.edu	37	14	23587927	23587927	+	Missense_Mutation	SNP	C	C	T	rs61737804		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:23587927C>T	uc001wiv.1	-	1	548	c.374G>A	c.(373-375)CGG>CAG	p.R125Q		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		CTCTGGCCCCCGGGGCTCCTC	0.672	NSCLC(63;1230 1818 14565 22565)		NA											4	54					0	0	0.000602	0	0
HEATR5A	25938	broad.mit.edu	37	14	31855777	31855777	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:31855777G>A	uc001wrf.3	-	3	392	c.315C>T	c.(313-315)GCC>GCT	p.A105A	HEATR5A_uc010ami.2_Silent_p.A3A|HEATR5A_uc001wrg.1_Intron|HEATR5A_uc010tpk.1_Silent_p.A398A	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	392							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CACTCATTACGGCATCTGATA	0.373			NA											10	164					0	0	0.006214	0	0
FRMD6	122786	broad.mit.edu	37	14	52188672	52188672	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:52188672G>A	uc001wzd.2	+	12	1651	c.1366G>A	c.(1366-1368)GAG>AAG	p.E456K	FRMD6_uc001wzb.2_Missense_Mutation_p.E448K|FRMD6_uc001wzc.2_Missense_Mutation_p.E448K|FRMD6_uc001wze.2_Missense_Mutation_p.E379K|FRMD6_uc001wzf.2_Missense_Mutation_p.E149K|FRMD6_uc001wzg.2_Missense_Mutation_p.E98K	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	456						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GTCAGAAATAGAGATGTTGGT	0.418			NA											19	42					0	0	0.008871	0	0
NID2	22795	broad.mit.edu	37	14	52505539	52505539	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:52505539C>A	uc001wzo.2	-	9	2417	c.2183G>T	c.(2182-2184)CGG>CTG	p.R728L	NID2_uc010tqs.1_Missense_Mutation_p.R728L|NID2_uc010tqt.1_Missense_Mutation_p.R728L|NID2_uc001wzp.2_Missense_Mutation_p.R728L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	728	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GGCAAAGACCCGGTCCACGTT	0.522			NA											20	76					5.26018e-13	8.28312e-13	0.012319	1	0
WDHD1	11169	broad.mit.edu	37	14	55411173	55411173	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:55411173G>A	uc001xbm.1	-	25	3144	c.3066C>T	c.(3064-3066)TTC>TTT	p.F1022F	WDHD1_uc010aom.1_Silent_p.F539F|WDHD1_uc001xbn.1_Silent_p.F899F	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	1022	HMG box.					cytoplasm|nucleoplasm	DNA binding			skin(1)	1						ACCACATCTGGAACCCGGTCT	0.318			NA											12	32					0	0	0.001368	0	0
DLGAP5	9787	broad.mit.edu	37	14	55643878	55643878	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:55643878C>T	uc001xbs.2	-	8	1168	c.951G>A	c.(949-951)CTG>CTA	p.L317L	DLGAP5_uc001xbt.2_Silent_p.L317L	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	317					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						TCAGACCATCCAGTGGCTGAA	0.383			NA											18	34					0	0	0.006122	0	0
PCNX	22990	broad.mit.edu	37	14	71445031	71445031	+	Silent	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:71445031A>T	uc001xmo.2	+	6	2423	c.1977A>T	c.(1975-1977)ACA>ACT	p.T659T	PCNX_uc001xmn.3_Silent_p.T659T|PCNX_uc010are.1_Silent_p.T659T	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	659						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CTGAACACACACACAAAGCTC	0.493			NA											25	124					0	0	0.00333	0	0
GPR65	8477	broad.mit.edu	37	14	88477216	88477216	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:88477216C>G	uc001xvv.2	+	2	555	c.25C>G	c.(25-27)CAG>GAG	p.Q9E		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	9	Extracellular (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						TATTGAAGAACAGCATGACCT	0.348			NA									OREG0031336	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	5	47					0	0	0.000602	0	0
CPSF2	53981	broad.mit.edu	37	14	92600367	92600367	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:92600367G>T	uc001yah.1	+	4	399	c.162G>T	c.(160-162)CAG>CAT	p.Q54H		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	54					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		ATGTTCACCAGATTGATGCAG	0.433	Ovarian(78;28 1788 18702 44111)		NA											37	112					1.52319e-26	2.81134e-26	0.00874	1	0
KIAA1409	57578	broad.mit.edu	37	14	94063707	94063707	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:94063707G>T	uc001ybv.1	+	21	2745	c.2662G>T	c.(2662-2664)GAA>TAA	p.E888*	KIAA1409_uc001ybs.1_Nonsense_Mutation_p.E888*	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1065						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CATTGCAGTGGAAAAAGTTGC	0.423			NA											11	43					1.58986e-06	1.99374e-06	0.008291	1	0
OR4M2	390538	broad.mit.edu	37	15	22369217	22369217	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:22369217G>T	uc010tzu.1	+	1	642	c.642G>T	c.(640-642)CTG>CTT	p.L214L	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGATTGCTCTGTTAATGTCCT	0.483			NA											45	422					1.61863e-15	2.69916e-15	0.00361	1	0
GABRG3	2567	broad.mit.edu	37	15	27572044	27572044	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:27572044G>T	uc001zbg.1	+	4	525	c.359G>T	c.(358-360)AGC>ATC	p.S120I	GABRG3_uc001zbf.2_Missense_Mutation_p.S120I	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	120	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ACTCTGAACAGCAACATGGTG	0.458	NSCLC(114;800 1656 7410 37729 45293)		NA											23	57					3.01185e-09	4.23839e-09	0.003954	1	0
RYR3	6263	broad.mit.edu	37	15	34072493	34072493	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:34072493C>A	uc001zhi.2	+	65	9289	c.9219C>A	c.(9217-9219)CGC>CGA	p.R3073R	RYR3_uc010bar.2_Silent_p.R3073R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3073					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCCTTAATCGCTACAATCCAC	0.537			NA											7	14					8.12818e-05	9.34516e-05	0.001984	1	0
RPAP1	26015	broad.mit.edu	37	15	41820068	41820069	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41820068_41820069GG>AT	uc001zod.2	-	11	1541_1542	c.1417_1418CC>AT	c.(1417-1419)CCT>ATT	p.P473I		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	473						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CTCATCTCCAGGAGCCACCAGC	0.584			NA											4	49					0	0	0.004672	0	0
RPAP1	26015	broad.mit.edu	37	15	41820194	41820194	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41820194G>C	uc001zod.2	-	11	1416	c.1292C>G	c.(1291-1293)GCA>GGA	p.A431G		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	431						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GACACTGCCTGCTAGCCGGTC	0.542			NA											3	16					0	0	0.009096	0	0
RPAP1	26015	broad.mit.edu	37	15	41822100	41822100	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41822100G>A	uc001zod.2	-	8	1145	c.1021C>T	c.(1021-1023)CAG>TAG	p.Q341*		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	341						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGCAAGTCCTGGGTCCAGTGG	0.612			NA											7	21					0	0	0.00308	0	0
RPAP1	26015	broad.mit.edu	37	15	41822157	41822157	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41822157G>A	uc001zod.2	-	8	1088	c.964C>T	c.(964-966)CCT>TCT	p.P322S		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	322						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TCTTTCTGAGGGGTCACGGGC	0.592			NA											8	23					0	0	0.004482	0	0
RPAP1	26015	broad.mit.edu	37	15	41823307	41823307	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41823307G>A	uc001zod.2	-	7	981	c.857C>T	c.(856-858)TCT>TTT	p.S286F		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	286						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GACATTAGCAGAGGGTCCTCC	0.572			NA											56	168					0	0	0.00361	0	0
RPAP1	26015	broad.mit.edu	37	15	41823309	41823309	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41823309G>A	uc001zod.2	-	7	979	c.855C>T	c.(853-855)CCC>CCT	p.P285P		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	285						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CATTAGCAGAGGGTCCTCCTG	0.572			NA											56	170					0	0	0.00361	0	0
RPAP1	26015	broad.mit.edu	37	15	41823359	41823359	+	Nonsense_Mutation	SNP	G	G	A	rs78256246		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41823359G>A	uc001zod.2	-	7	929	c.805C>T	c.(805-807)CAA>TAA	p.Q269*		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	269						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTTTGCTCTTGCGTGTGGCTG	0.562			NA											41	158					0	0	0.00361	0	0
RPAP1	26015	broad.mit.edu	37	15	41823373	41823373	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:41823373G>C	uc001zod.2	-	7	915	c.791C>G	c.(790-792)TCT>TGT	p.S264C		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	264						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTGGCTGTGAGATCTCAAGAA	0.572			NA											39	137					0	0	0.00361	0	0
GATM	2628	broad.mit.edu	37	15	45657019	45657019	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:45657019G>A	uc001zvc.2	-	7	1347	c.1018C>T	c.(1018-1020)CCT>TCT	p.P340S	GATM_uc001zvb.2_Missense_Mutation_p.P211S|GATM_uc010uev.1_Missense_Mutation_p.P393S	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	340					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GGTGTTGGAGGAGTAATGATA	0.343			NA											6	13					0	0	0.00308	0	0
HDC	3067	broad.mit.edu	37	15	50540498	50540498	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:50540498G>A	uc001zxz.2	-	10	1190	c.1084C>T	c.(1084-1086)CTC>TTC	p.L362F	HDC_uc001zxy.2_Missense_Mutation_p.L105F|HDC_uc010uff.1_Intron	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	362					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ACGAACCAGAGTTTAACAGAG	0.542	GBM(95;1627 1936 6910 9570)		NA											17	45					0	0	0.004007	0	0
TRPM7	54822	broad.mit.edu	37	15	50899520	50899520	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:50899520T>C	uc001zyt.3	-	20	2850	c.2586A>G	c.(2584-2586)GCA>GCG	p.A862A	TRPM7_uc010bew.1_Silent_p.A862A|TRPM7_uc001zyu.2_Silent_p.A420A	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	862	Helical; (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		ATCCTAAATATGCCAACTAAT	0.264			NA											14	32					0	0	0.001855	0	0
HERC1	8925	broad.mit.edu	37	15	63988517	63988517	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:63988517G>A	uc002amp.2	-	27	5075	c.4927C>T	c.(4927-4929)CAG>TAG	p.Q1643*	HERC1_uc010uil.1_Nonsense_Mutation_p.Q627*	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1643					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ACGAGGATCTGATGAAGTGCC	0.413			NA											3	9					0	0	0.004672	0	0
NTRK3	4916	broad.mit.edu	37	15	88690601	88690601	+	Silent	SNP	C	C	A	rs138266478		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:88690601C>A	uc002bme.1	-	5	591	c.429G>T	c.(427-429)TCG>TCT	p.S143S	NTRK3_uc002bmh.2_Silent_p.S143S|NTRK3_uc002bmf.1_Silent_p.S143S|NTRK3_uc010upl.1_Silent_p.S45S|NTRK3_uc010bnh.1_Silent_p.S143S|NTRK3_uc002bmg.2_Silent_p.S143S	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	143	LRR 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGAGCTGCCACGAGAGTGTGG	0.453			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			11	23					0.000978159	0.00108646	0.010729	1	0
CHD2	1106	broad.mit.edu	37	15	93558024	93558024	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr15:93558024C>T	uc002bsp.2	+	37	5366	c.4791C>T	c.(4789-4791)ACC>ACT	p.T1597T	CHD2_uc002bso.1_Silent_p.T1597T	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1597					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGTCCCATACCTCACACAACC	0.527			NA											7	105					0	0	0.00308	0	0
PRSS22	64063	broad.mit.edu	37	16	2903323	2903323	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:2903323G>A	uc002cry.1	-	6	791	c.725C>T	c.(724-726)TCC>TTC	p.S242F	PRSS22_uc002crz.1_Missense_Mutation_p.S132F	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	242	Peptidase S1.	Charge relay system (By similarity).			proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						GGGGCCCCCGGAGTCGCCCTG	0.711			NA											9	21					0	0	0.006214	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883154	19883154	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:19883154C>A	uc002dgt.2	-	2	1122	c.1014G>T	c.(1012-1014)ATG>ATT	p.M338I	GPRC5B_uc010vav.1_Missense_Mutation_p.M364I	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	338	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						TGTGTTCATCCATGGAGAAGG	0.587			NA											23	133					2.21704e-12	3.42183e-12	0.00278	1	0
ERN2	10595	broad.mit.edu	37	16	23703537	23703538	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:23703537_23703538GG>TT	uc002dma.3	-	18	2528_2529	c.2359_2360CC>AA	c.(2359-2361)CCC>AAC	p.P787N	ERN2_uc010bxp.2_Missense_Mutation_p.P735N	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	739	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGCCAGACAGGGAGCCCCTGTG	0.604			NA											58	66					0	0	0.004672	0	0
SULT1A2	6799	broad.mit.edu	37	16	28604843	28604843	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:28604843T>C	uc002dqg.1	-	5	770	c.419A>G	c.(418-420)TAC>TGC	p.Y140C	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Missense_Mutation_p.Y140C	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	140					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						GTAGAAGTGGTAGTAGGAAAC	0.577			NA											52	47					0	0	0.00361	0	0
SLC6A2	6530	broad.mit.edu	37	16	55703493	55703493	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:55703493G>A	uc002eif.2	+	3	402	c.291G>A	c.(289-291)CCG>CCA	p.P97P	SLC6A2_uc010ccd.2_Silent_p.P97P|SLC6A2_uc002eig.2_Silent_p.P97P|SLC6A2_uc002eih.2_Silent_p.P97P|SLC6A2_uc002eii.2_5'Flank	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	97	Helical; Name=2; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TCTTGATCCCGTACACACTGT	0.577			NA											5	74					0	0	0.001168	0	0
CNOT1	23019	broad.mit.edu	37	16	58608961	58608961	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:58608961C>T	uc002env.2	-	15	2070	c.1777G>A	c.(1777-1779)GAA>AAA	p.E593K	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.E593K|CNOT1_uc002enx.2_Missense_Mutation_p.E593K|CNOT1_uc002enz.1_Missense_Mutation_p.E22K	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	593					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTGAGGTATTCACGACGTGAA	0.393			NA											8	71					0	0	0.00308	0	0
SLC12A4	6560	broad.mit.edu	37	16	67997387	67997387	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:67997387C>T	uc002euz.2	-	2	332	c.191G>A	c.(190-192)AGG>AAG	p.R64K	SLC12A4_uc010ceu.2_Missense_Mutation_p.R58K|SLC12A4_uc010vkh.1_Missense_Mutation_p.R33K|SLC12A4_uc010vki.1_Missense_Mutation_p.R64K|SLC12A4_uc010vkj.1_Intron|SLC12A4_uc002eva.2_Missense_Mutation_p.R64K|SLC12A4_uc002evb.2_RNA|SLC12A4_uc010cew.1_5'UTR	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	64	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGCCAGGTTCCTGTCATAGTA	0.547			NA											25	31					0	0	0.007291	0	0
DPEP3	64180	broad.mit.edu	37	16	68014139	68014139	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:68014139G>A	uc002evc.3	-	1	314	c.220C>T	c.(220-222)CTG>TTG	p.L74L	DPEP3_uc010cex.2_Silent_p.L74L	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	49					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		GGGGAGCCCAGCGTGGAGAGG	0.612			NA											10	12					0	0	0.008291	0	0
PMFBP1	83449	broad.mit.edu	37	16	72153719	72153719	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:72153719C>A	uc002fcc.3	-	20	3225	c.3053G>T	c.(3052-3054)TGT>TTT	p.C1018F	PMFBP1_uc002fcd.2_Intron|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Intron	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	1018										ovary(2)	2		Ovarian(137;0.179)				AAAAAAATCACACTTATTTTT	0.433			NA											3	37					0.004672	0.00502765	0.004672	1	0
FA2H	79152	broad.mit.edu	37	16	74750356	74750356	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:74750356G>A	uc002fde.1	-	6	996	c.928C>T	c.(928-930)CTC>TTC	p.L310F	FA2H_uc002fdd.1_Missense_Mutation_p.L83F|FA2H_uc010vmy.1_RNA	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	310	Helical; (Potential).				cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						ATGTCATAGAGGACGTAGCCC	0.597			NA											12	18					0	0	0.00245	0	0
KLHL36	79786	broad.mit.edu	37	16	84691417	84691417	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:84691417G>T	uc002fig.2	+	3	1145	c.1004G>T	c.(1003-1005)CGG>CTG	p.R335L	KLHL36_uc010chl.2_Missense_Mutation_p.R334L	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	335	Kelch 1.									skin(2)	2						CCCGCCCGGCGGAGCCACCAC	0.652			NA											5	12					3.59834e-05	4.22295e-05	0.001168	1	0
CBFA2T3	863	broad.mit.edu	37	16	88945811	88945811	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:88945811G>C	uc002fmm.1	-	11	1715	c.1529C>G	c.(1528-1530)TCG>TGG	p.S510W	CBFA2T3_uc002fml.1_Missense_Mutation_p.S424W|CBFA2T3_uc002fmk.1_Missense_Mutation_p.S9W	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	510	Potential.				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CTCCGCGTCCGACACGGCTTT	0.672			NA	T	RUNX1	AML								18	35					0	0	0.012319	0	0
CDH15	1013	broad.mit.edu	37	16	89258091	89258091	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr16:89258091C>A	uc002fmt.2	+	10	1481	c.1404C>A	c.(1402-1404)ACC>ACA	p.T468T		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	468	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCACCGGCACCCTGTCCATCG	0.721			NA											11	14					1.58986e-06	1.99374e-06	0.008291	1	0
TP53	7157	broad.mit.edu	37	17	7577536	7577536	+	Missense_Mutation	SNP	T	T	A	rs67185453		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:7577536T>A	uc002gim.2	-	7	939	c.745A>T	c.(745-747)AGG>TGG	p.R249W	TP53_uc002gig.1_Missense_Mutation_p.R249W|TP53_uc002gih.2_Missense_Mutation_p.R249W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117W|TP53_uc010cng.1_Missense_Mutation_p.R117W|TP53_uc002gii.1_Missense_Mutation_p.R117W|TP53_uc010cnh.1_Missense_Mutation_p.R249W|TP53_uc010cni.1_Missense_Mutation_p.R249W|TP53_uc002gij.2_Missense_Mutation_p.R249W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156W|TP53_uc002gio.2_Missense_Mutation_p.R117W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.N247_P250delNRRP(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.N247_R248delNR(1)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.R249_T256delRPILTIIT(1)|p.R249_P250>SS(1)|p.G245fs*14(1)|p.R249fs*19(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGATGGGCCTCCGGTTCATG	0.567	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	24					0	0	0.00278	0	0
PIK3R6	146850	broad.mit.edu	37	17	8732150	8732150	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:8732150C>G	uc002glq.1	-	11	1287	c.1047G>C	c.(1045-1047)GGG>GGC	p.G349G	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	349					platelet activation	cytosol					0						GCTCATCAGCCCCCGTGGGAA	0.662			NA											7	15					0	0	0.00308	0	0
NCOR1	9611	broad.mit.edu	37	17	16068441	16068441	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:16068441G>A	uc002gpo.2	-	5	710	c.470C>T	c.(469-471)TCC>TTC	p.S157F	NCOR1_uc002gpn.2_Missense_Mutation_p.S157F|NCOR1_uc002gpp.1_Missense_Mutation_p.S48F|NCOR1_uc002gpr.2_Missense_Mutation_p.S48F|NCOR1_uc002gps.1_Missense_Mutation_p.S157F|NCOR1_uc010coz.1_5'UTR|NCOR1_uc010cpb.1_Missense_Mutation_p.S157F|NCOR1_uc010cpa.1_Missense_Mutation_p.S157F|NCOR1_uc002gpu.2_Missense_Mutation_p.S157F	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	157	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AATTGGAGAGGATGGAGCTTC	0.393			NA											6	80					0	0	0.00308	0	0
RAB11FIP4	84440	broad.mit.edu	37	17	29857480	29857480	+	Missense_Mutation	SNP	G	G	T	rs147400342		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:29857480G>T	uc002hgn.1	+	14	2019	c.1790G>T	c.(1789-1791)CGC>CTC	p.R597L	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.R495L	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	597	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.|FIP-RBD.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				ACCGCCTCGCGCGATGAGGTA	0.587			NA											16	94					9.16793e-09	1.2644e-08	0.00499	1	0
C17orf102	400591	broad.mit.edu	37	17	32904574	32904574	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:32904574G>T	uc002hie.1	-	2	565	c.476C>A	c.(475-477)GCT>GAT	p.A159D		NM_207454	NP_997337	A2RUQ5	CQ102_HUMAN	hypothetical protein LOC400591	159								p.A159T(1)		ovary(1)	1						gaggacaagagctggttttgt	0.244			NA											10	30					2.52707e-12	3.89068e-12	0.006214	1	0
LIG3	3980	broad.mit.edu	37	17	33323635	33323635	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:33323635G>C	uc002hik.1	+	11	1894	c.1786G>C	c.(1786-1788)GAT>CAT	p.D596H	LIG3_uc002hij.2_Missense_Mutation_p.D596H	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	596					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	GTTTGTTTTTGATTGTATCTA	0.403			NA						Other_BER_factors					15	117					0	0	0.006122	0	0
LIG3	3980	broad.mit.edu	37	17	33323660	33323660	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:33323660G>C	uc002hik.1	+	11	1919	c.1811G>C	c.(1810-1812)AGC>ACC	p.S604T	LIG3_uc002hij.2_Missense_Mutation_p.S604T	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	604					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	AATGATGTCAGCTTGATGGAC	0.433			NA						Other_BER_factors					11	102					0	0	0.010729	0	0
KRT37	8688	broad.mit.edu	37	17	39579095	39579095	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:39579095C>A	uc002hwp.1	-	3	714	c.667G>T	c.(667-669)GAC>TAC	p.D223Y	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	223	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GCCTCCAGGTCGGCCTTGGCC	0.662			NA											17	55					4.7546e-09	6.67576e-09	0.004007	1	0
KRT36	8689	broad.mit.edu	37	17	39645847	39645847	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:39645847G>T	uc002hwt.2	-	1	270	c.270C>A	c.(268-270)AAC>AAA	p.N90K		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	90	Head.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				TCTCGCTGCCGTTGAAGGAGC	0.632			NA											28	113					2.08457e-15	3.4576e-15	0.010818	1	0
BRCA1	672	broad.mit.edu	37	17	41234512	41234513	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:41234512_41234513CC>AA	uc002icq.2	-	12	4497_4498	c.4265_4266GG>TT	c.(4264-4266)GGG>GTT	p.G1422V	BRCA1_uc010whp.1_Missense_Mutation_p.G272V|BRCA1_uc010whl.1_Missense_Mutation_p.G319V|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.G1351V|BRCA1_uc002icu.2_Missense_Mutation_p.G319V|BRCA1_uc010cyx.2_Missense_Mutation_p.G1375V|BRCA1_uc002ict.2_Missense_Mutation_p.G1422V|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.G151V|BRCA1_uc002idc.1_Missense_Mutation_p.G318V|BRCA1_uc010whr.1_Missense_Mutation_p.G272V	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1422	Interaction with PALB2.				androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AAGGCTGGCTCCCATGCTGTTC	0.45			NA	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			20	69					0	0	0.004672	0	0
CUEDC1	404093	broad.mit.edu	37	17	55950963	55950963	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:55950963C>A	uc002ivd.1	-	4	1299	c.580G>T	c.(580-582)GAC>TAC	p.D194Y	CUEDC1_uc002ive.1_Missense_Mutation_p.D194Y	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	194										skin(2)	2						TGTATGCTGTCCAGCTGCTGG	0.587			NA											26	69					3.28513e-13	5.19936e-13	0.003954	1	0
PPM1E	22843	broad.mit.edu	37	17	57046944	57046944	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:57046944G>T	uc002iwx.2	+	4	955	c.828G>T	c.(826-828)GGG>GGT	p.G276G	PPM1E_uc010ddd.2_Silent_p.G39G	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	285	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			ATGGCCATGGGGGAGTAGATG	0.493			NA											23	50					5.35356e-11	7.94729e-11	0.00278	1	0
SOX9	6662	broad.mit.edu	37	17	70117637	70117637	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:70117637C>A	uc002jiw.2	+	1	477	c.105C>A	c.(103-105)TGC>TGA	p.C35*	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	35					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			GCTCGCCCTGCCCGTCGGGCT	0.672	Pancreas(42;83 1041 2320 35205 39456)		NA											4	16					0.00909568	0.00963801	0.009096	1	0
SDK2	54549	broad.mit.edu	37	17	71334933	71334933	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:71334933C>A	uc010dfm.2	-	45	6312	c.6312G>T	c.(6310-6312)GAG>GAT	p.E2104D	SDK2_uc002jjt.3_Missense_Mutation_p.E1244D	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	2104	Cytoplasmic (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CCGAGTCGCTCTCCGTGTAGC	0.617			NA											12	33					3.07112e-06	3.79015e-06	0.010729	1	0
KIF19	124602	broad.mit.edu	37	17	72346894	72346894	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:72346894G>A	uc002jkm.3	+	12	1575	c.1437G>A	c.(1435-1437)CAG>CAA	p.Q479Q	KIF19_uc002jkj.2_Silent_p.Q479Q|KIF19_uc002jkk.2_Silent_p.Q437Q|KIF19_uc002jkl.2_Silent_p.Q437Q	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	479					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGGAGGAGCAGCGAAAGGAGT	0.652			NA											38	90					0	0	0.013114	0	0
BTBD17	388419	broad.mit.edu	37	17	72356255	72356255	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:72356255G>T	uc002jkn.2	-	2	215	c.215C>A	c.(214-216)GCG>GAG	p.A72E		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	72	BTB.					extracellular region					0						ATCGGTGCCCGCAGCCTGCAC	0.662			NA											12	30					2.27111e-07	2.96771e-07	0.001368	1	0
GGA3	23163	broad.mit.edu	37	17	73240717	73240717	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:73240717T>G	uc002jni.1	-	4	292	c.283A>C	c.(283-285)AAA>CAA	p.K95Q	GGA3_uc002jnj.1_Intron|GGA3_uc010wrw.1_Intron|GGA3_uc002jnk.1_Missense_Mutation_p.K23Q|GGA3_uc010wrx.1_Intron|GGA3_uc010wry.1_Missense_Mutation_p.K23Q|GGA3_uc010wrz.1_Intron	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	95	VHS.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			GAGACGACTTTGATTAACTCA	0.488			NA											69	187					0	0	0.00361	0	0
MGAT5B	146664	broad.mit.edu	37	17	74921063	74921063	+	Silent	SNP	G	G	A	rs114240204	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:74921063G>A	uc002jti.2	+	8	1177	c.1074G>A	c.(1072-1074)CCG>CCA	p.P358P	MGAT5B_uc002jth.2_Silent_p.P347P	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	347	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						TAGGGGTACCGCCAGGCCGGG	0.607			NA											15	112					0	0	0.004007	0	0
CBX2	84733	broad.mit.edu	37	17	77758716	77758716	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:77758716G>T	uc002jxc.2	+	5	1516	c.1474G>T	c.(1474-1476)GAC>TAC	p.D492Y		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	492					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GACCAGCCAGGACTGGAAGCC	0.637			NA											18	37					2.37509e-13	3.78797e-13	0.010504	1	0
RPTOR	57521	broad.mit.edu	37	17	78931471	78931471	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:78931471A>T	uc002jyt.1	+	29	4223	c.3418A>T	c.(3418-3420)AGC>TGC	p.S1140C	RPTOR_uc010wug.1_Missense_Mutation_p.S982C|RPTOR_uc002jyu.1_Missense_Mutation_p.S33C	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	1140	WD 3.				cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CCTCCTCATGAGCTCAGGAGA	0.632			NA											23	125					0	0	0.00278	0	0
SLC38A10	124565	broad.mit.edu	37	17	79219556	79219556	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr17:79219556G>A	uc002jzz.1	-	16	3535	c.3160C>T	c.(3160-3162)CGG>TGG	p.R1054W	SLC38A10_uc002jzy.1_Missense_Mutation_p.R972W	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	1054					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCAAGGTCCCGCCGTCGCCTC	0.672			NA											17	41					0	0	0.004007	0	0
ANKRD12	23253	broad.mit.edu	37	18	9255152	9255152	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:9255152T>C	uc002knv.2	+	9	2144	c.1887T>C	c.(1885-1887)CAT>CAC	p.H629H	ANKRD12_uc002knw.2_Silent_p.H606H|ANKRD12_uc002knx.2_Silent_p.H606H|ANKRD12_uc010dkx.1_Silent_p.H336H	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	629						nucleus				ovary(2)|central_nervous_system(1)	3						ATGAAGATCATAGTCCAACAT	0.174			NA											5	63					0	0	0.001168	0	0
MPPE1	65258	broad.mit.edu	37	18	11885721	11885721	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:11885721A>C	uc002kqf.2	-	10	1603	c.962T>G	c.(961-963)GTC>GGC	p.V321G	MPPE1_uc002kqn.2_Missense_Mutation_p.V258G|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Missense_Mutation_p.V322G|MPPE1_uc002kqk.2_Missense_Mutation_p.V299G|MPPE1_uc002kql.2_Missense_Mutation_p.V322G|MPPE1_uc002kqm.2_Missense_Mutation_p.V258G	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	321					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						GAAAGATGGGACGCTGAGCTC	0.527			NA											5	41					0	0	0.00308	0	0
RIOK3	8780	broad.mit.edu	37	18	21057143	21057143	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:21057143G>T	uc002kui.3	+	11	1872	c.1255G>T	c.(1255-1257)GTC>TTC	p.V419F	RIOK3_uc010dls.2_Missense_Mutation_p.V419F|RIOK3_uc010xas.1_Missense_Mutation_p.V403F|RIOK3_uc010xat.1_Missense_Mutation_p.V163F	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	419	Protein kinase.				chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATTGAAATAGGTCTGGTTGAT	0.413			NA											20	49					1.28384e-07	1.68826e-07	0.012319	1	0
LAMA3	3909	broad.mit.edu	37	18	21485527	21485527	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:21485527G>T	uc002kuq.2	+	52	6743	c.6657G>T	c.(6655-6657)CTG>CTT	p.L2219L	LAMA3_uc002kur.2_Silent_p.L2163L|LAMA3_uc002kus.3_Silent_p.L610L|LAMA3_uc002kut.3_Silent_p.L554L	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2219	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTAAAACCCTGAGTTCCAACA	0.393			NA											27	50					3.65163e-15	6.0247e-15	0.00632	1	0
LAMA3	3909	broad.mit.edu	37	18	21512237	21512237	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:21512237G>A	uc002kuq.2	+	66	8776	c.8690G>A	c.(8689-8691)AGC>AAC	p.S2897N	LAMA3_uc002kur.2_Missense_Mutation_p.S2841N|LAMA3_uc002kus.3_Missense_Mutation_p.S1288N|LAMA3_uc002kut.3_Missense_Mutation_p.S1232N	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2897	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTTGTATTAGCAATGTTTTT	0.468			NA											33	73					0	0	0.003271	0	0
TTC39C	125488	broad.mit.edu	37	18	21698196	21698196	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:21698196G>T	uc002kuw.2	+	8	1638	c.1186G>T	c.(1186-1188)GTT>TTT	p.V396F	TTC39C_uc002kuu.2_Missense_Mutation_p.V335F	NM_001135993	NP_001129465	Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C isoform 1	396							binding			ovary(1)	1						CTTGACTGCAGGTGAGTCGCC	0.313			NA											5	45					0.000602214	0.000670085	0.000602	1	0
DSC2	1824	broad.mit.edu	37	18	28648987	28648987	+	Missense_Mutation	SNP	G	G	A	rs1617629		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:28648987G>A	uc002kwl.3	-	15	2835	c.2381C>T	c.(2380-2382)TCG>TTG	p.S794L	DSC2_uc002kwk.3_Missense_Mutation_p.S794L	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	794	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GCAGGATTCCGAGGTCTGGTG	0.592			NA											11	62					0	0	0.008291	0	0
MOCOS	55034	broad.mit.edu	37	18	33775249	33775249	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:33775249A>T	uc002kzq.3	+	2	195	c.172A>T	c.(172-174)ACC>TCC	p.T58S		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	58					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TGCAGGTGCCACCTTGTTCTC	0.388			NA											56	87					0	0	0.00361	0	0
RIT2	6014	broad.mit.edu	37	18	40503541	40503541	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:40503541C>T	uc002lav.2	-	4	595	c.422G>A	c.(421-423)CGC>CAC	p.R141H	RIT2_uc010dnf.2_Missense_Mutation_p.R141H	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	141					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						ACTCACCTGGCGGAACTGTTC	0.458			NA											24	191					0	0	0.003954	0	0
SETBP1	26040	broad.mit.edu	37	18	42530368	42530368	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:42530368G>T	uc010dni.2	+	4	1359	c.1063G>T	c.(1063-1065)GTC>TTC	p.V355F		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	355						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCTGGATTGGGTCAAGAATGC	0.488			NA							Schinzel-Giedion_syndrome				16	82					5.01169e-05	5.84854e-05	0.00499	1	0
ALPK2	115701	broad.mit.edu	37	18	56203989	56203989	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:56203989G>T	uc002lhj.3	-	5	3644	c.3430C>A	c.(3430-3432)CAG>AAG	p.Q1144K	ALPK2_uc002lhk.1_Missense_Mutation_p.Q475K	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1144							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GAACCCTGCTGGGACAGGCTC	0.522			NA											12	201					1.08611e-07	1.43736e-07	0.010729	1	0
CDH20	28316	broad.mit.edu	37	18	59217383	59217383	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:59217383C>A	uc010dps.1	+	10	1833	c.1821C>A	c.(1819-1821)AGC>AGA	p.S607R	CDH20_uc002lif.2_Missense_Mutation_p.S601R	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	607	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TGTCCTGCAGCCCAGAGGCCT	0.597			NA											23	42					3.62473e-10	5.26772e-10	0.012319	1	0
SERPINB12	89777	broad.mit.edu	37	18	61232776	61232776	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:61232776C>A	uc010xen.1	+	6	744	c.744C>A	c.(742-744)ACC>ACA	p.T248T	SERPINB12_uc010xeo.1_Silent_p.T268T	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	248					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						TGAGGTACACCAAGGGGAAGC	0.443			NA											4	79					0.00024832	0.000280318	0.009096	1	0
FBXO15	201456	broad.mit.edu	37	18	71796748	71796748	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:71796748A>G	uc002lle.2	-	5	785	c.449T>C	c.(448-450)GTT>GCT	p.V150A	FBXO15_uc002llf.2_Missense_Mutation_p.V226A	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	150										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		ATACCATATAACAGTAACTGA	0.368			NA											7	35					0	0	0.00308	0	0
ZNF516	9658	broad.mit.edu	37	18	74091856	74091856	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:74091856C>A	uc010dqx.1	-	3	2449	c.2214G>T	c.(2212-2214)AGG>AGT	p.R738S	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	738					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CCCGCGTCGACCTCGCACTTA	0.592			NA											37	25					1.836e-18	3.19886e-18	0.003755	1	0
NFATC1	4772	broad.mit.edu	37	18	77227449	77227449	+	Splice_Site	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr18:77227449G>C	uc010xfg.1	+	8	2413	c.1960_splice	c.e8-1	p.N654_splice	NFATC1_uc002lnc.1_Splice_Site_p.N654_splice|NFATC1_uc010xff.1_Splice_Site_p.R625_splice|NFATC1_uc002lnd.2_Splice_Site_p.N654_splice|NFATC1_uc002lne.2_Splice_Site_p.N182_splice|NFATC1_uc010xfh.1_Splice_Site_p.N654_splice|NFATC1_uc010xfi.1_Splice_Site_p.N641_splice|NFATC1_uc010xfj.1_Splice_Site_p.N182_splice|NFATC1_uc002lnf.2_Splice_Site_p.N641_splice|NFATC1_uc002lng.2_Splice_Site_p.N641_splice|NFATC1_uc010xfk.1_Splice_Site_p.N641_splice	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic						intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		TTCTCCTGTAGAATTCTCTGG	0.612	GBM(151;1210 2593 28719 45011)		NA											3	79					0	0	0.004672	0	0
ABCA7	10347	broad.mit.edu	37	19	1055905	1055905	+	Splice_Site	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:1055905G>T	uc002lqw.3	+	31	4437	c.4206_splice	c.e31-1	p.G1402_splice	ABCA7_uc010dsb.1_Splice_Site_p.G1264_splice|ABCA7_uc002lqy.2_5'Flank|ABCA7_uc010dsc.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7						phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTCCCACAGCCTGAAGACT	0.582			NA											45	31					3.68337e-26	6.77828e-26	0.00361	1	0
TMIGD2	126259	broad.mit.edu	37	19	4292808	4292808	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:4292808C>T	uc002lzx.1	-	5	683	c.637G>A	c.(637-639)GGG>AGG	p.G213R	TMIGD2_uc010dtv.1_Missense_Mutation_p.G209R	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	213	Cytoplasmic (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTCCTTCCCCTCTCCAGAG	0.542			NA											52	43					0	0	0.00361	0	0
VAV1	7409	broad.mit.edu	37	19	6772756	6772756	+	Translation_Start_Site	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:6772756G>A	uc002mfu.1	+	1	35	c.-62G>A	c.(-64--60)GCGTG>GCATG		VAV1_uc010xjh.1_Translation_Start_Site|VAV1_uc010dva.1_Translation_Start_Site	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CAGGGCAGGCGTGCGGGCGGG	0.672			NA											18	14					0	0	0.008871	0	0
MUC16	94025	broad.mit.edu	37	19	8976586	8976586	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:8976586G>A	uc002mkp.2	-	74	42594	c.42390C>T	c.(42388-42390)TCC>TCT	p.S14130S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.S930S|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	14161	SEA 14.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCACCTGAGGGAGATCAGTT	0.557			NA											9	16					0	0	0.004482	0	0
ZNF560	147741	broad.mit.edu	37	19	9578679	9578679	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:9578679C>T	uc002mlp.1	-	10	1154	c.944G>A	c.(943-945)AGT>AAT	p.S315N	ZNF560_uc010dwr.1_Missense_Mutation_p.S209N	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TTTTTCTCCACTCTGAGTTTT	0.398			NA											6	82					0	0	0.001168	0	0
CD97	976	broad.mit.edu	37	19	14515282	14515282	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:14515282T>C	uc002myl.2	+	13	1660	c.1537T>C	c.(1537-1539)TGC>CGC	p.C513R	CD97_uc002mym.2_Missense_Mutation_p.C464R|CD97_uc002myn.2_Missense_Mutation_p.C420R	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	513	Extracellular (Potential).|GPS.				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						CACCGAGGGCTGCCAGGTGCT	0.617			NA											37	54					0	0	0.003271	0	0
CYP4F22	126410	broad.mit.edu	37	19	15651465	15651465	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:15651465G>T	uc002nbh.3	+	8	1043	c.876G>T	c.(874-876)GAG>GAT	p.E292D		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	292						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						AGGGGGCCGAGGCCTGGCTTA	0.647			NA											33	50					6.00712e-18	1.0379e-17	0.012213	1	0
MYO9B	4650	broad.mit.edu	37	19	17313008	17313008	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:17313008A>G	uc010eak.2	+	28	4884	c.4732A>G	c.(4732-4734)ACT>GCT	p.T1578A	MYO9B_uc002nfi.2_Missense_Mutation_p.T1578A|MYO9B_uc002nfj.1_Missense_Mutation_p.T1578A|MYO9B_uc002nfl.1_Missense_Mutation_p.T127A	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1578	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CAACCTGGCCACTGAGCGTGG	0.562			NA											17	12					0	0	0.006122	0	0
JAK3	3718	broad.mit.edu	37	19	17955088	17955088	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:17955088C>A	uc002nhn.3	-	2	239	c.139G>T	c.(139-141)GAC>TAC	p.D47Y	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.D47Y|JAK3_uc010xpx.1_Missense_Mutation_p.D47Y|JAK3_uc010xpy.1_Missense_Mutation_p.D47Y	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	47	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GCCAAGTGGTCCCCAAAGGAG	0.657			2	Mis		acute megakaryocytic leukemia|								8	10					0.00448238	0.00485721	0.004482	1	0
MAST3	23031	broad.mit.edu	37	19	18235560	18235560	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:18235560G>T	uc002nhz.3	+	10	967	c.967G>T	c.(967-969)GGC>TGC	p.G323C		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	323							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TGGGCAGCTGGGCCTGGCCAA	0.532			NA											9	23					0.00829132	0.00890708	0.008291	1	0
MAST3	23031	broad.mit.edu	37	19	18235570	18235570	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:18235570A>T	uc002nhz.3	+	10	977	c.977A>T	c.(976-978)AAG>ATG	p.K326M		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	326							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GGCCTGGCCAAGGACCCCCTG	0.502			NA											11	25					0	0	0.010729	0	0
ZNF257	113835	broad.mit.edu	37	19	22271202	22271202	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:22271202C>A	uc010ecx.2	+	4	819	c.650C>A	c.(649-651)ACT>AAT	p.T217N	ZNF257_uc010ecy.2_Missense_Mutation_p.T185N	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	217	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCAGCTCTTACTCGACATAAG	0.388			NA											10	45					9.70103e-10	1.40001e-09	0.008291	1	0
ZNF98	148198	broad.mit.edu	37	19	22586258	22586258	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:22586258G>T	uc002nqt.2	-	2	209	c.87C>A	c.(85-87)TGC>TGA	p.C29*		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CGGTGTCCAGGCATTGCCACT	0.413			NA											49	72					1.89013e-27	3.50943e-27	0.00361	1	0
ZNF536	9745	broad.mit.edu	37	19	31040290	31040290	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:31040290C>A	uc002nsu.1	+	4	3902	c.3764C>A	c.(3763-3765)CCC>CAC	p.P1255H	ZNF536_uc010edd.1_Missense_Mutation_p.P1255H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GAGCGGGGGCCCCAGAGCCTG	0.597			NA											14	32					3.27435e-08	4.41789e-08	0.00245	1	0
SLC7A9	11136	broad.mit.edu	37	19	33355045	33355045	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:33355045C>A	uc002ntv.3	-	4	552	c.435G>T	c.(433-435)AAG>AAT	p.K145N	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Missense_Mutation_p.K145N|SLC7A9_uc002ntw.3_5'UTR	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	145	Extracellular (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	TTTGAGGAGGCTTGCAGCCCA	0.592	GBM(181;1335 2108 9644 44178 46689)		NA											8	35					0.00010058	0.000115213	0.001368	1	0
KIAA0355	9710	broad.mit.edu	37	19	34818678	34818678	+	Silent	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:34818678A>T	uc002nvd.3	+	5	1708	c.849A>T	c.(847-849)GCA>GCT	p.A283A		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	283										ovary(1)	1	Esophageal squamous(110;0.162)					ATTTCCAGGCATATAAGATAG	0.338			NA											14	34					0	0	0.003163	0	0
RYR1	6261	broad.mit.edu	37	19	38933001	38933001	+	Missense_Mutation	SNP	G	G	A	rs118192160		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:38933001G>A	uc002oit.2	+	3	308	c.178G>A	c.(178-180)GAT>AAT	p.D60N	RYR1_uc002oiu.2_Missense_Mutation_p.D60N	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	60	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGTGCCCCCCGATCTGGCCAT	0.632			NA											18	97					0	0	0.007413	0	0
PHLDB3	653583	broad.mit.edu	37	19	44001416	44001416	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:44001416C>A	uc002own.3	-	6	938	c.679G>T	c.(679-681)GAT>TAT	p.D227Y	PHLDB3_uc010eit.2_5'Flank|PHLDB3_uc002owo.2_Missense_Mutation_p.D227Y	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	227	Potential.										0		Prostate(69;0.0153)				TGGGCCACATCCAGTTGTTCC	0.378			NA											7	28					2.0095e-06	2.49483e-06	0.001984	1	0
IGLON5	402665	broad.mit.edu	37	19	51826942	51826942	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:51826942G>T	uc002pwc.2	+	3	185	c.185G>T	c.(184-186)CGC>CTC	p.R62L		NM_001101372	NP_001094842	A6NGN9	IGLO5_HUMAN	IgLON family member 5 precursor	62	Ig-like C2-type 1.					extracellular region					0						CACGTGACCCGCGTGGCCTGG	0.647			NA											12	34					7.03913e-09	9.75131e-09	0.001368	1	0
ZNF610	162963	broad.mit.edu	37	19	52869860	52869860	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:52869860G>T	uc002pyx.3	+	6	1635	c.1229G>T	c.(1228-1230)GGG>GTG	p.G410V	ZNF610_uc002pyy.3_Missense_Mutation_p.G410V|ZNF610_uc002pyz.3_Missense_Mutation_p.G367V|ZNF610_uc002pza.2_Missense_Mutation_p.G410V	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	410	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AAAGTCTTTGGGCGCAAATTA	0.423			NA											7	35					0.00307968	0.00334304	0.00308	1	0
ZNF534	147658	broad.mit.edu	37	19	52937242	52937242	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:52937242T>G	uc002pzk.2	+	2	111	c.50T>G	c.(49-51)TTC>TGC	p.F17C	ZNF534_uc002pzj.1_Missense_Mutation_p.F17C|ZNF534_uc010epo.1_Missense_Mutation_p.F17C|ZNF534_uc002pzl.2_Missense_Mutation_p.F17C	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCATAGAATTCTCTCAGGAG	0.453			NA											27	64					0	0	0.005443	0	0
ZNF28	7576	broad.mit.edu	37	19	53304938	53304938	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:53304938T>C	uc002qad.2	-	4	280	c.160A>G	c.(160-162)ATG>GTG	p.M54V	ZNF28_uc002qac.2_Missense_Mutation_p.M1V|ZNF28_uc010eqe.2_5'UTR	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		GTCTTCATCATGCATTTGGAA	0.363			NA											57	67					0	0	0.00361	0	0
NLRP12	91662	broad.mit.edu	37	19	54308698	54308698	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:54308698C>A	uc002qch.3	-	5	2470	c.2250G>T	c.(2248-2250)AAG>AAT	p.K750N	NLRP12_uc010eqw.2_Missense_Mutation_p.K33N|NLRP12_uc002qci.3_Missense_Mutation_p.K750N|NLRP12_uc002qcj.3_Missense_Mutation_p.K751N|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.K751N	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	750					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGCGGCACCTCTTCAGCCTGG	0.423			NA											15	75					4.93089e-13	7.7843e-13	0.00245	1	0
MYADM	91663	broad.mit.edu	37	19	54377348	54377348	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:54377348G>T	uc002qcl.2	+	3	713	c.565G>T	c.(565-567)GCG>TCG	p.A189S	MYADM_uc002qcm.2_Missense_Mutation_p.A189S|MYADM_uc002qcn.2_Missense_Mutation_p.A189S|MYADM_uc002qco.2_Missense_Mutation_p.A189S|MYADM_uc002qcp.2_Missense_Mutation_p.A189S	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	189	MARVEL 2.|Helical; (Potential).					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		CATCATCTTCGCGTTCATCAG	0.652			NA											31	154					3.99451e-17	6.80708e-17	0.009535	1	0
LILRA1	11024	broad.mit.edu	37	19	55106637	55106637	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:55106637A>G	uc002qgh.1	+	5	613	c.431A>G	c.(430-432)CAT>CGT	p.H144R	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.H144R	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	144	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GTGACCCTCCATTGTGTCTCA	0.542			NA											21	136					0	0	0.002299	0	0
KIR2DS4	3809	broad.mit.edu	37	19	55349047	55349047	+	Silent	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:55349047T>A	uc002qhm.1	+	3	133	c.87T>A	c.(85-87)CCT>CCA	p.P29P	KIR2DS4_uc010yfj.1_Silent_p.P22P|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Silent_p.P29P|KIR2DS4_uc002qhn.1_5'UTR	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	29	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACAGAAAACCTTCCTTCCTGG	0.502			NA											44	76					0	0	0.011902	0	0
NLRP7	199713	broad.mit.edu	37	19	55445885	55445885	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:55445885G>A	uc002qih.3	-	7	2519	c.2443C>T	c.(2443-2445)CGC>TGC	p.R815C	NLRP7_uc002qig.3_Missense_Mutation_p.R787C|NLRP7_uc002qii.3_Missense_Mutation_p.R815C|NLRP7_uc010esk.2_Missense_Mutation_p.R815C|NLRP7_uc010esl.2_Missense_Mutation_p.R843C	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	815							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGTTTTGGGCGTGTCATGGTC	0.517			NA											14	81					0	0	0.00245	0	0
NLRP7	199713	broad.mit.edu	37	19	55450993	55450993	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:55450993G>T	uc002qih.3	-	4	1270	c.1194C>A	c.(1192-1194)CTC>CTA	p.L398L	NLRP7_uc002qig.3_Silent_p.L398L|NLRP7_uc002qii.3_Silent_p.L398L|NLRP7_uc010esk.2_Silent_p.L398L|NLRP7_uc010esl.2_Silent_p.L426L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	398	NACHT.		L -> R (in HYDM).				ATP binding	p.L398L(1)		large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ACCGGCTGCAGAGGAAACGCA	0.692			NA											7	20					1.58986e-06	1.99374e-06	0.008291	1	0
NLRP7	199713	broad.mit.edu	37	19	55451569	55451569	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:55451569G>T	uc002qih.3	-	4	694	c.618C>A	c.(616-618)TAC>TAA	p.Y206*	NLRP7_uc002qig.3_Nonsense_Mutation_p.Y206*|NLRP7_uc002qii.3_Nonsense_Mutation_p.Y206*|NLRP7_uc010esk.2_Nonsense_Mutation_p.Y206*|NLRP7_uc010esl.2_Nonsense_Mutation_p.Y234*	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	206	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GGTAGAACGCGTATCTGAGCG	0.587			NA											32	58					1.39806e-14	2.27642e-14	0.008361	1	0
SAPS1	22870	broad.mit.edu	37	19	55751251	55751251	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:55751251C>A	uc002qjw.3	-	13	1748	c.1506G>T	c.(1504-1506)TGG>TGT	p.W502C	SAPS1_uc002qjv.2_Missense_Mutation_p.W564C	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	502					regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CGAAGGCTTCCCACTGCTCCT	0.632			NA											11	30					1.5842e-08	2.18003e-08	0.001855	1	0
U2AF2	11338	broad.mit.edu	37	19	56180848	56180848	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:56180848G>T	uc002qlu.2	+	11	2138	c.1083G>T	c.(1081-1083)CCG>CCT	p.P361P	U2AF2_uc002qlt.2_Silent_p.P357P	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	361					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TGCAAGTGCCGGGCTTGATGA	0.647			NA											4	31					0.00909568	0.00963801	0.009096	1	0
NLRP5	126206	broad.mit.edu	37	19	56538692	56538692	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:56538692G>A	uc002qmj.2	+	7	1093	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	NLRP5_uc002qmi.2_Missense_Mutation_p.D346N	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	365	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGACGGTTTCGATGACCTGGG	0.547			NA											4	21					0	0	0.009096	0	0
ZNF667	63934	broad.mit.edu	37	19	56953937	56953937	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:56953937G>T	uc002qnd.2	-	5	589	c.427C>A	c.(427-429)CCT>ACT	p.P143T	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.P143T|ZNF667_uc010etm.2_Missense_Mutation_p.P86T	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CATTTTAAAGGTTTCTTCCCT	0.378			NA											9	103					3.09899e-07	3.99083e-07	0.004482	1	0
ZIM2	23619	broad.mit.edu	37	19	57293363	57293363	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:57293363T>A	uc002qnr.2	-	9	986	c.604A>T	c.(604-606)AGG>TGG	p.R202W	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnq.2_Missense_Mutation_p.R202W|ZIM2_uc010etp.2_Missense_Mutation_p.R202W|ZIM2_uc010ygs.1_Missense_Mutation_p.R202W	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	202	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		ATCACCTCCCTGTAGAGGTTT	0.512			NA											12	105					0	0	0.001368	0	0
ZIM3	114026	broad.mit.edu	37	19	57647108	57647108	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:57647108G>C	uc002qnz.1	-	5	983	c.597C>G	c.(595-597)AGC>AGG	p.S199R		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	199	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCTTCCACAGCTATGACATT	0.433			NA											37	134					0	0	0.00623	0	0
RNASEH1	246243	broad.mit.edu	37	2	3598004	3598004	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:3598004C>A	uc002qxt.2	-	4	558	c.468G>T	c.(466-468)CCG>CCT	p.P156P	RNASEH1_uc002qxs.2_Silent_p.P39P	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1	156	RNase H.				RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		TTCCTGCTCGCGGCCTTCTAC	0.502			NA											47	116					3.39706e-21	6.17827e-21	0.00361	1	0
LPIN1	23175	broad.mit.edu	37	2	11943039	11943039	+	Missense_Mutation	SNP	G	G	T	rs145608684	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:11943039G>T	uc010yjn.1	+	15	2059	c.1785G>T	c.(1783-1785)AAG>AAT	p.K595N	LPIN1_uc010yjm.1_Missense_Mutation_p.K680N|LPIN1_uc002rbt.2_Missense_Mutation_p.K595N|LPIN1_uc010yjo.1_Missense_Mutation_p.K96N	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	595					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CCAGGGTAAAGCATGAATCAT	0.468			NA											7	252					1.26484e-09	1.81694e-09	0.00308	1	0
PLB1	151056	broad.mit.edu	37	2	28739673	28739673	+	Splice_Site	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:28739673A>T	uc002rmb.1	+	2	56	c.56_splice	c.e2-2	p.G19_splice	PLB1_uc010ezj.1_Splice_Site_p.G19_splice	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GCTTTCTTTCAGGGACCCCTC	0.488			NA											28	77					0	0	0.005443	0	0
PREPL	9581	broad.mit.edu	37	2	44548542	44548542	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:44548542C>A	uc002ruf.2	-	14	2172	c.2137G>T	c.(2137-2139)GAC>TAC	p.D713Y	PREPL_uc002rug.2_Missense_Mutation_p.D647Y|PREPL_uc002ruh.2_Missense_Mutation_p.D651Y|PREPL_uc010fax.2_Missense_Mutation_p.D713Y|PREPL_uc002rui.3_Missense_Mutation_p.D624Y|PREPL_uc002ruj.1_Missense_Mutation_p.D624Y|PREPL_uc002ruk.1_Missense_Mutation_p.D713Y	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	713					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGTGCTGTCAAGTCCAAGT	0.343			NA											7	27					0.00307968	0.00334304	0.00308	1	0
SRBD1	55133	broad.mit.edu	37	2	45616508	45616508	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:45616508C>A	uc002rus.2	-	21	3005	c.2929G>T	c.(2929-2931)GTA>TTA	p.V977L	SRBD1_uc010yoc.1_Missense_Mutation_p.V496L	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	977	S1 motif.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ATGTTGAGTACTTGGACTTCC	0.448			NA											18	52					1.00905e-13	1.6176e-13	0.008871	1	0
BCL11A	53335	broad.mit.edu	37	2	60688990	60688990	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:60688990G>T	uc002sae.1	-	4	1285	c.1057C>A	c.(1057-1059)CCC>ACC	p.P353T	BCL11A_uc002sab.2_Missense_Mutation_p.P353T|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.P319T|BCL11A_uc002sad.1_Missense_Mutation_p.P201T|BCL11A_uc002saf.1_Missense_Mutation_p.P319T	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	353	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GCCAGGAAGGGCGGCTTGCTA	0.647			NA	T	IGH@	B-CLL								21	87					1.28384e-07	1.68826e-07	0.012319	1	0
USP34	9736	broad.mit.edu	37	2	61575333	61575333	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:61575333T>C	uc002sbe.2	-	15	1979	c.1957A>G	c.(1957-1959)ATT>GTT	p.I653V		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	653					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCCAGGCAAATGCCTGCTTGA	0.458			NA											6	41					0	0	0.001168	0	0
NAGK	55577	broad.mit.edu	37	2	71300684	71300684	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:71300684A>G	uc002shp.3	+	6	945	c.539A>G	c.(538-540)GAT>GGT	p.D180G	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_Missense_Mutation_p.D31G|NAGK_uc002shr.2_Missense_Mutation_p.D129G	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	180					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	GCTCCTCATGATATCGGCTAC	0.522			NA											76	253					0	0	0.00361	0	0
DYSF	8291	broad.mit.edu	37	2	71886086	71886086	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:71886086C>T	uc002sie.2	+	43	5093	c.4717C>T	c.(4717-4719)CAG>TAG	p.Q1573*	DYSF_uc010feg.2_Nonsense_Mutation_p.Q1604*|DYSF_uc010feh.2_Nonsense_Mutation_p.Q1580*|DYSF_uc002sig.3_Nonsense_Mutation_p.Q1559*|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Nonsense_Mutation_p.Q1594*|DYSF_uc010fef.2_Nonsense_Mutation_p.Q1611*|DYSF_uc010fei.2_Nonsense_Mutation_p.Q1590*|DYSF_uc010fek.2_Nonsense_Mutation_p.Q1591*|DYSF_uc010fej.2_Nonsense_Mutation_p.Q1581*|DYSF_uc010fel.2_Nonsense_Mutation_p.Q1560*|DYSF_uc010feo.2_Nonsense_Mutation_p.Q1605*|DYSF_uc010fem.2_Nonsense_Mutation_p.Q1595*|DYSF_uc010fen.2_Nonsense_Mutation_p.Q1612*|DYSF_uc002sif.2_Nonsense_Mutation_p.Q1574*|DYSF_uc010yqy.1_Nonsense_Mutation_p.Q454*|DYSF_uc010yqz.1_Nonsense_Mutation_p.Q334*	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1573	Cytoplasmic (Potential).|C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GCTGGCCGCCCAGGGACCCCA	0.557			NA											28	118					0	0	0.009535	0	0
TET3	200424	broad.mit.edu	37	2	74307667	74307667	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:74307667C>T	uc002skb.3	+	3	2223	c.2223C>T	c.(2221-2223)ATC>ATT	p.I741I		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	741							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGAAGGTCATCTACACGGGGA	0.557			NA											5	26					0	0	0.001168	0	0
REG1B	5968	broad.mit.edu	37	2	79314699	79314699	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:79314699G>T	uc002sny.2	-	2	152	c.40C>A	c.(40-42)CTG>ATG	p.L14M	REG1B_uc010ffv.1_Missense_Mutation_p.L14M|REG1B_uc010ffw.2_Missense_Mutation_p.L14M	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	14					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						AGGAACATCAGGGAGGAGATC	0.483			NA											6	21					0.00116845	0.0012886	0.001168	1	0
REG1A	5967	broad.mit.edu	37	2	79348739	79348739	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:79348739G>A	uc002snz.2	+	3	219	c.116G>A	c.(115-117)GGC>GAC	p.G39D	REG1A_uc010ffx.1_Missense_Mutation_p.G39D|REG1A_uc010ysd.1_Missense_Mutation_p.G39D	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	39	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TGCCCAGAAGGCACCAATGCC	0.532			NA											83	194					0	0	0.00361	0	0
REG3A	5068	broad.mit.edu	37	2	79386464	79386464	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:79386464T>A	uc002sod.1	-	1	323	c.68A>T	c.(67-69)CAG>CTG	p.Q23L	REG3A_uc002soe.1_Missense_Mutation_p.Q23L|REG3A_uc002sof.1_Missense_Mutation_p.Q23L	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	23					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						ACCTTGAACCTGAGACAGCAG	0.527			NA											11	38					0	0	0.008291	0	0
RAB6C	84084	broad.mit.edu	37	2	130738066	130738066	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:130738066T>C	uc002tpx.1	+	1	832	c.378T>C	c.(376-378)AAT>AAC	p.N126N	uc002tpw.1_5'Flank	NM_032144	NP_115520	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	126	GTP (By similarity).				protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			lung(1)	1	Colorectal(110;0.1)					TAGTAGGAAATAGAACAGATC	0.413			NA											73	168					0	0	0.00361	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541593	133541593	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:133541593G>A	uc002ttp.2	-	14	3165	c.2791C>T	c.(2791-2793)CCC>TCC	p.P931S	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	931	Poly-Pro.			PP -> QS (in Ref. 5; BAA22433).			protein binding				0						CCTGGAGGGGGCGGAGGGGAA	0.622			NA											4	30					0	0	0.009096	0	0
LRP1B	53353	broad.mit.edu	37	2	141806654	141806654	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:141806654G>A	uc002tvj.1	-	11	2662	c.1690C>T	c.(1690-1692)CAC>TAC	p.H564Y	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	564	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTTTCTGCGTGAAAGTCTAAA	0.438	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			8	111					0	0	0.006214	0	0
LRP1B	53353	broad.mit.edu	37	2	142238100	142238100	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:142238100G>T	uc002tvj.1	-	3	1180	c.208C>A	c.(208-210)CCC>ACC	p.P70T	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	70	Extracellular (Potential).|LDL-receptor class A 1.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCTCCTCGGGACCTGAAAAG	0.373	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			7	22					2.7689e-08	3.76038e-08	0.001984	1	0
ERMN	57471	broad.mit.edu	37	2	158178139	158178139	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:158178139G>T	uc002tzh.2	-	3	761	c.499C>A	c.(499-501)CAA>AAA	p.Q167K	ERMN_uc010zcj.1_Missense_Mutation_p.Q61K|ERMN_uc010zck.1_Missense_Mutation_p.Q147K|ERMN_uc002tzi.2_Missense_Mutation_p.Q180K	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	167						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						ATGTCAGCTTGGCTAGGTTTT	0.348			NA											43	66					8.20599e-20	1.47518e-19	0.011902	1	0
ACVR1	90	broad.mit.edu	37	2	158656003	158656003	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:158656003C>A	uc002tzm.3	-	4	342	c.3G>T	c.(1-3)ATG>ATT	p.M1I	ACVR1_uc002tzn.3_Missense_Mutation_p.M1I|ACVR1_uc010fog.2_Missense_Mutation_p.M1I	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	1					BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CTCCATCTACCATTGTACAAC	0.383			NA											10	27					0.00136819	0.00150356	0.001368	1	0
LY75	4065	broad.mit.edu	37	2	160673472	160673472	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:160673472T>C	uc002ubc.3	-	30	4294	c.4225A>G	c.(4225-4227)ATT>GTT	p.I1409V	LY75_uc002ubb.3_Missense_Mutation_p.I1409V|LY75_uc010fos.2_Missense_Mutation_p.I1409V	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1409	Extracellular (Potential).|C-type lectin 9.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTTTTTGAATAACACTGTAA	0.353			NA											26	26					0	0	0.003954	0	0
PLA2R1	22925	broad.mit.edu	37	2	160833814	160833814	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:160833814C>A	uc002ube.1	-	15	2589	c.2382G>T	c.(2380-2382)TGG>TGT	p.W794C	PLA2R1_uc010zcp.1_Missense_Mutation_p.W794C|PLA2R1_uc002ubf.2_Missense_Mutation_p.W794C	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	794	Extracellular (Potential).|C-type lectin 4.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTTTGCATATCCATTCACGTT	0.348			NA											14	26					2.61681e-11	3.92207e-11	0.00245	1	0
TTN	7273	broad.mit.edu	37	2	179412568	179412568	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:179412568A>T	uc010zfg.1	-	288	86305	c.86081T>A	c.(86080-86082)GTG>GAG	p.V28694E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V22389E|TTN_uc010zfi.1_Missense_Mutation_p.V22322E|TTN_uc010zfj.1_Missense_Mutation_p.V22197E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29621							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATGCTCACTCGATCTGT	0.453			NA											6	47					0	0	0.001168	0	0
TTN	7273	broad.mit.edu	37	2	179598167	179598167	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:179598167C>T	uc010zfg.1	-	51	12345	c.12121G>A	c.(12121-12123)GCA>ACA	p.A4041T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A702T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4968							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCGTGCCTGCCACTGTGTAC	0.468			NA											7	195					0	0	0.004482	0	0
ITGA4	3676	broad.mit.edu	37	2	182399575	182399575	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:182399575C>G	uc002unu.2	+	27	3679	c.2916C>G	c.(2914-2916)CCC>CCG	p.P972P	ITGA4_uc002unv.2_Silent_p.P217P	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	972	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATCAAAGACCCAAACGTTATT	0.313			NA											4	35					0	0	0.009096	0	0
IGFBP5	3488	broad.mit.edu	37	2	217541567	217541567	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:217541567C>T	uc002vgj.3	-	4	1500	c.726G>A	c.(724-726)TGG>TGA	p.W242*		NM_000599	NP_000590	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	242	Thyroglobulin type-1.				negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding				0		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTCCACGCACCAGCAGATGC	0.617			NA											5	129					0	0	0.001168	0	0
SP100	6672	broad.mit.edu	37	2	231308915	231308915	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:231308915A>T	uc002vqt.2	+	4	434	c.293A>T	c.(292-294)AAC>ATC	p.N98I	SP100_uc002vqs.2_Missense_Mutation_p.N98I|SP100_uc002vqu.1_Missense_Mutation_p.N98I|SP100_uc010zmb.1_Missense_Mutation_p.N98I|SP100_uc002vqq.1_Missense_Mutation_p.N98I|SP100_uc002vqr.1_Missense_Mutation_p.N73I|SP100_uc010zmc.1_Missense_Mutation_p.N73I|SP100_uc002vqv.1_Missense_Mutation_p.N62I	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	98	HSR.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCTTGTAGAAACCTGGTCCCT	0.383			NA											11	60					0	0	0.010729	0	0
CHRNG	1146	broad.mit.edu	37	2	233406084	233406084	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:233406084C>A	uc002vsx.1	+	5	372	c.351C>A	c.(349-351)AAC>AAA	p.N117K	CHRNG_uc010fyd.2_Missense_Mutation_p.N117K|CHRNG_uc010fye.1_Intron	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	117	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		GTGCATACAGCGTGGACGGTG	0.657			NA											13	107					7.03913e-09	9.75131e-09	0.001368	1	0
UGT1A9	54600	broad.mit.edu	37	2	234580712	234580712	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:234580712G>T	uc002vus.2	+	1	169	c.132G>T	c.(130-132)GTG>GTT	p.V44V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Silent_p.V44V	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	44					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	TGAGGTCGGTGGTGGAGAAAC	0.532			NA											14	67					7.93312e-07	1.00908e-06	0.00245	1	0
COL6A3	1293	broad.mit.edu	37	2	238275811	238275811	+	Silent	SNP	G	G	T	rs140516220		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:238275811G>T	uc002vwl.2	-	11	5304	c.5019C>A	c.(5017-5019)GGC>GGA	p.G1673G	COL6A3_uc002vwo.2_Silent_p.G1467G|COL6A3_uc010znj.1_Silent_p.G1066G	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1673	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGATGGAGTCGCCATCTTCAT	0.473			NA											9	25					2.17888e-05	2.58145e-05	0.006214	1	0
SLC23A2	9962	broad.mit.edu	37	20	4842670	4842670	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:4842670G>T	uc002wlg.1	-	15	1923	c.1548C>A	c.(1546-1548)AAC>AAA	p.N516K	SLC23A2_uc010zqr.1_Missense_Mutation_p.N401K|SLC23A2_uc002wlh.1_Missense_Mutation_p.N516K	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	516	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GCACAAAGAGGTTCCGGGAAG	0.468			NA											12	33					1.08611e-07	1.43736e-07	0.010729	1	0
CST3	1471	broad.mit.edu	37	20	23614635	23614635	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:23614635T>A	uc002wtm.2	-	3	434	c.359A>T	c.(358-360)AAA>ATA	p.K120I	CST3_uc002wtn.1_Missense_Mutation_p.K120I	NM_000099	NP_000090	P01034	CYTC_HUMAN	cystatin C precursor	120					defense response|fibril organization|negative regulation of blood vessel remodeling|negative regulation of collagen catabolic process|negative regulation of elastin catabolic process|negative regulation of extracellular matrix disassembly	extracellular space	beta-amyloid binding|cysteine-type endopeptidase inhibitor activity|protease binding			ovary(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					GCAGAATGCTTTCTGTGAAAG	0.537			NA											16	53					0	0	0.004007	0	0
VSX1	30813	broad.mit.edu	37	20	25056973	25056973	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:25056973G>T	uc002wuf.2	-	5	1057	c.1022C>A	c.(1021-1023)CCT>CAT	p.P341H	VSX1_uc002wue.2_Intron|VSX1_uc010gdd.1_Intron|VSX1_uc010gde.1_Intron|VSX1_uc010gdf.1_Intron	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	341					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ACCAGCCCCAGGGTGCACTTT	0.597			NA											12	58					5.16669e-11	7.68823e-11	0.010729	1	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:29628263A>G	uc010ztl.1	+	3	207	c.175A>G	c.(175-177)ATT>GTT	p.I59V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.I11V					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TAGCTGCTTTATTAGATGCAA	0.363			NA											3	67					0	0	0.000602	0	0
PTPRT	11122	broad.mit.edu	37	20	40980762	40980762	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:40980762C>A	uc002xkg.2	-	10	1908	c.1724G>T	c.(1723-1725)GGG>GTG	p.G575V	PTPRT_uc010ggj.2_Missense_Mutation_p.G575V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	575	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GACAGGGGGCCCAAAGCCCTT	0.502			NA											19	66					7.21436e-19	1.26761e-18	0.008871	1	0
PREX1	57580	broad.mit.edu	37	20	47361667	47361667	+	Missense_Mutation	SNP	G	G	C	rs141887028		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:47361667G>C	uc002xtw.1	-	3	332	c.309C>G	c.(307-309)ATC>ATG	p.I103M		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	103	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGATGTCTTCGATGTTCGAGA	0.483			NA											4	204					0	0	0.000602	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870553	51870553	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:51870553G>T	uc002xwo.2	+	2	1512	c.556G>T	c.(556-558)GTC>TTC	p.V186F		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	186					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TTCTCGGTCCGTCTCGAAACC	0.557			NA											13	60					9.05144e-12	1.37653e-11	0.001855	1	0
DIDO1	11083	broad.mit.edu	37	20	61513243	61513243	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:61513243C>A	uc002ydr.1	-	16	4329	c.4065G>T	c.(4063-4065)CCG>CCT	p.P1355P	DIDO1_uc002yds.1_Silent_p.P1355P	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1355					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					ACGGAGGTGCCGGCACCCCGT	0.587	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											50	120					1.47857e-17	2.54053e-17	0.00361	1	0
GRIK1	2897	broad.mit.edu	37	21	30953768	30953768	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:30953768C>A	uc002yno.1	-	13	2353	c.1889G>T	c.(1888-1890)GGA>GTA	p.G630V	GRIK1_uc002ynn.2_Missense_Mutation_p.G615V|GRIK1_uc011acs.1_Missense_Mutation_p.G630V|GRIK1_uc011act.1_Missense_Mutation_p.G491V|GRIK1_uc010glq.1_Missense_Mutation_p.G473V	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	630	Cytoplasmic (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AGCTCCAACTCCAAACCAGAA	0.483			NA											43	36					1.7489e-18	3.05567e-18	0.011902	1	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933445	31933445	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:31933445C>A	uc011adb.1	-	1	164	c.164G>T	c.(163-165)GGG>GTG	p.G55V		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	55						intermediate filament					0						CCAGTATCCCCCATAGCATGA	0.453			NA											140	89					5.62954e-76	1.09083e-75	0.00361	1	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971160	31971160	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:31971160C>A	uc011adc.1	-	1	34	c.34G>T	c.(34-36)GAC>TAC	p.D12Y	KRTAP22-1_uc011add.1_5'Flank	NM_181604	NP_853635	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	12						intermediate filament					0						TAGCCATGGTCGCCGTAGTAG	0.542			NA											102	56					3.52173e-36	6.63792e-36	0.00361	1	0
OLIG2	10215	broad.mit.edu	37	21	34399437	34399437	+	Silent	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:34399437G>C	uc002yqx.1	+	2	425	c.267G>C	c.(265-267)GCG>GCC	p.A89A		NM_005806	NP_005797	Q13516	OLIG2_HUMAN	oligodendrocyte lineage transcription factor 2	89						cytoplasm|nucleus|plasma membrane	DNA binding			central_nervous_system(2)	2						CGTCGTCGGCGGCTGCGTCGT	0.632			NA	T	TRA@	T-ALL								6	10					0	0	0.001168	0	0
DSCAM	1826	broad.mit.edu	37	21	41459132	41459132	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:41459132C>A	uc002yyq.1	-	22	4385	c.3933G>T	c.(3931-3933)GGG>GGT	p.G1311G	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1311	Extracellular (Potential).|Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GAGAAGGGTCCCCAACAGCCT	0.468	Melanoma(134;970 1778 1785 21664 32388)		NA											8	95					1.12685e-05	1.36628e-05	0.004482	1	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047279	46047279	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:46047279C>T	uc002zfp.3	+	1	240	c.191C>T	c.(190-192)CCC>CTC	p.P64L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	64	25 X 5 AA repeats of C-C-X(3).					keratin filament					0						ACCTGTGAGCCCAGCCCCTGC	0.657			NA											23	142					0	0	0.00278	0	0
DIP2A	23181	broad.mit.edu	37	21	47929244	47929244	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:47929244C>T	uc002zjo.2	+	7	1042	c.859C>T	c.(859-861)CCA>TCA	p.P287S	DIP2A_uc011afy.1_Missense_Mutation_p.P223S|DIP2A_uc011afz.1_Missense_Mutation_p.P287S|DIP2A_uc002zjl.2_Missense_Mutation_p.P287S|DIP2A_uc002zjm.2_Missense_Mutation_p.P287S|DIP2A_uc010gql.2_Missense_Mutation_p.P244S|DIP2A_uc002zjn.2_Missense_Mutation_p.P287S|DIP2A_uc002zjp.1_Missense_Mutation_p.P32S	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	287					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		AAAGCGCCCTCCACTGAAGGA	0.493			NA											44	85					0	0	0.00361	0	0
PRAME	23532	broad.mit.edu	37	22	22893340	22893340	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:22893340G>T	uc002zwf.2	-	3	349	c.193C>A	c.(193-195)CAC>AAC	p.H65N	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.H49N|PRAME_uc010gtr.2_Missense_Mutation_p.H65N|PRAME_uc002zwg.2_Missense_Mutation_p.H65N|PRAME_uc002zwh.2_Missense_Mutation_p.H65N|PRAME_uc002zwi.2_Missense_Mutation_p.H65N|PRAME_uc002zwj.2_Missense_Mutation_p.H65N|PRAME_uc002zwk.2_Missense_Mutation_p.H65N	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	65					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		GTCTGGCTGTGTCTCCCGTCA	0.612	Melanoma(73;1707 1838 15168 27201)		NA											17	89					2.39187e-15	3.95677e-15	0.008871	1	0
APOL3	80833	broad.mit.edu	37	22	36537770	36537770	+	Silent	SNP	C	C	A	rs146525352	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:36537770C>A	uc003aot.2	-	3	725	c.687G>T	c.(685-687)GCG>GCT	p.A229A	APOL3_uc003aoq.2_Silent_p.A158A|APOL3_uc003aor.2_Silent_p.A158A|APOL3_uc003aos.2_Silent_p.A158A|APOL3_uc003aou.2_Silent_p.A29A|APOL3_uc003aov.2_Silent_p.A29A	NM_145640	NP_663615	O95236	APOL3_HUMAN	apolipoprotein L3 isoform 1	229					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity				0						TCACAGCAGACGCTGCTCCCA	0.567			NA											3	29					0.00909568	0.00963801	0.009096	1	0
CACNG2	10369	broad.mit.edu	37	22	37098411	37098411	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:37098411C>T	uc003aps.1	-	1	493	c.211G>A	c.(211-213)GGG>AGG	p.G71R	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	71					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						AGTCAAGTACCTTCTAGGCAG	0.299			NA											18	55					0	0	0.006122	0	0
MFNG	4242	broad.mit.edu	37	22	37882095	37882095	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:37882095G>C	uc003ass.1	-	1	291	c.121C>G	c.(121-123)CTG>GTG	p.L41V	MFNG_uc011ani.1_5'UTR|MFNG_uc011anj.1_Missense_Mutation_p.L41V|CARD10_uc003ast.1_Intron	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	41	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)					GGCTGGCTCAGCTCGGGGGTC	0.652			NA											10	36					0	0	0.001368	0	0
ACO2	50	broad.mit.edu	37	22	41895792	41895792	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:41895792G>T	uc003bac.2	+	2	121	c.99G>T	c.(97-99)GCG>GCT	p.A33A	ACO2_uc003bad.2_Silent_p.A33A	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	33					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CCAAGGTGGCGATGAGCCACT	0.522			NA											49	255					2.64894e-19	4.6808e-19	0.00361	1	0
FAM118A	55007	broad.mit.edu	37	22	45726535	45726535	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:45726535G>C	uc003bfz.3	+	6	1190	c.574G>C	c.(574-576)GGC>CGC	p.G192R	FAM118A_uc003bga.3_Missense_Mutation_p.G192R|FAM118A_uc011aqr.1_Missense_Mutation_p.G10R	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	192						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CCACATTCACGGCCTCTACAC	0.522			NA											10	33					0	0	0.006214	0	0
CHL1	10752	broad.mit.edu	37	3	447382	447382	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:447382C>A	uc003bou.2	+	27	3886	c.3615C>A	c.(3613-3615)CCC>CCA	p.P1205P	CHL1_uc003bot.2_Silent_p.P1221P|CHL1_uc011asi.1_Silent_p.P1168P	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1205	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAACTTTTCCCCTTCGGGCAT	0.418			NA											9	20					0.000274275	0.000308498	0.004482	1	0
TTLL3	26140	broad.mit.edu	37	3	9877118	9877118	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:9877118G>A	uc003btg.2	+	13	2480	c.2264G>A	c.(2263-2265)GGG>GAG	p.G755E	ARPC4_uc003btc.1_Intron	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	755					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GCTGTTGGAGGGTCAAGAGTG	0.567			NA											16	135					0	0	0.004007	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067189	11067189	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:11067189C>A	uc010hdq.2	+	8	1180	c.769C>A	c.(769-771)CGT>AGT	p.R257S		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	257					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCTGTTCTTCCGTGGAGTGAC	0.587			NA											8	40					0.000442599	0.000496926	0.006214	1	0
FGD5	152273	broad.mit.edu	37	3	14861743	14861743	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:14861743A>T	uc003bzc.2	+	1	1275	c.1165A>T	c.(1165-1167)ATG>TTG	p.M389L	FGD5_uc011avk.1_Missense_Mutation_p.M389L	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	389					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GGAGAACCCCATGGTGGGGGC	0.607			NA											9	49					0	0	0.006214	0	0
KCNH8	131096	broad.mit.edu	37	3	19575056	19575056	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:19575056C>A	uc003cbk.1	+	16	2984	c.2789C>A	c.(2788-2790)GCA>GAA	p.A930E	KCNH8_uc010hex.1_Missense_Mutation_p.A391E	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	930	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AGCTGGAGTGCACACCAGCCT	0.527	NSCLC(124;1625 1765 8018 24930 42026)		NA											4	76					0.00909568	0.00963801	0.009096	1	0
PTPN23	25930	broad.mit.edu	37	3	47450286	47450286	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:47450286G>A	uc003crf.1	+	16	1447	c.1351G>A	c.(1351-1353)GAT>AAT	p.D451N	PTPN23_uc011baw.1_Missense_Mutation_p.D416N|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.D321N	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	451					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTGTTCACGGATGTGGAGGC	0.612			NA											23	85					0	0	0.00278	0	0
C3orf54	389119	broad.mit.edu	37	3	49841780	49841780	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:49841780T>A	uc003cxq.1	+	2	357	c.224T>A	c.(223-225)GTG>GAG	p.V75E		NM_203370	NP_976248	Q96EL1	CC054_HUMAN	hypothetical protein LOC389119	73											0				BRCA - Breast invasive adenocarcinoma(193;3.55e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		gaggaAGCAGTGGTGACAGAA	0.542			NA											16	46					0	0	0.003163	0	0
GRM2	2912	broad.mit.edu	37	3	51746673	51746673	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:51746673C>A	uc010hlv.2	+	3	874	c.635C>A	c.(634-636)TCT>TAT	p.S212Y	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	212	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	ACTGTGGCGTCTGAGGGCGAC	0.582			NA											20	57					2.4624e-09	3.48093e-09	0.008871	1	0
ITIH3	3699	broad.mit.edu	37	3	52840398	52840398	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:52840398C>A	uc003dfv.2	+	18	2068	c.2032C>A	c.(2032-2034)CGC>AGC	p.R678S	ITIH3_uc011bek.1_Intron	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	678					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CACAGTGCTGCGCCTTATTCA	0.612			NA											13	30					9.16793e-09	1.2644e-08	0.00499	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64617141	64617141	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:64617141G>T	uc003dmg.2	-	16	2411	c.2379C>A	c.(2377-2379)GAC>GAA	p.D793E	ADAMTS9_uc011bfo.1_Missense_Mutation_p.D765E|ADAMTS9_uc003dmh.1_Missense_Mutation_p.D622E|ADAMTS9_uc003dmk.1_Missense_Mutation_p.D793E	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	793	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CTAAGTAGTTGTCATCGTCTG	0.483			NA											6	108					8.12818e-05	9.34516e-05	0.001984	1	0
HTR1F	3355	broad.mit.edu	37	3	88040418	88040418	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:88040418C>G	uc003dqr.2	+	2	677	c.519C>G	c.(517-519)ATC>ATG	p.I173M		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	173	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	ATGAATGCATCATCAAGCACG	0.378			NA											7	42					0	0	0.001984	0	0
PROS1	5627	broad.mit.edu	37	3	93619740	93619740	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:93619740C>A	uc003drb.3	-	7	976	c.635G>T	c.(634-636)TGT>TTT	p.C212F	PROS1_uc010hoo.2_Missense_Mutation_p.C81F|PROS1_uc003dqz.3_Missense_Mutation_p.C81F	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	212	EGF-like 3; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	AGCTGTGCCACAAATGCTTGG	0.388			NA											6	35					8.12818e-05	9.34516e-05	0.001984	1	0
MINA	84864	broad.mit.edu	37	3	97686352	97686352	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:97686352C>A	uc003drz.1	-	2	592	c.86G>T	c.(85-87)GGG>GTG	p.G29V	MINA_uc003dsa.1_Missense_Mutation_p.G29V|MINA_uc003dsb.1_Missense_Mutation_p.G29V|MINA_uc003dsc.1_Missense_Mutation_p.G29V|MINA_uc010hpa.1_RNA|MINA_uc010hpb.1_Intron	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	29					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						AGCTGAAGGCCCCCCAGCTGC	0.483			NA											10	51					2.17888e-05	2.58145e-05	0.006214	1	0
TIGIT	201633	broad.mit.edu	37	3	114014612	114014612	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:114014612C>T	uc003ebg.1	+	2	316	c.282C>T	c.(280-282)ACC>ACT	p.T94T		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	94	Extracellular (Potential).|Ig-like V-type.				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						TGGGCCTCACCCTCCAGTCGC	0.577			NA											14	50					0	0	0.001855	0	0
FBXO40	51725	broad.mit.edu	37	3	121341270	121341270	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:121341270A>G	uc003eeg.2	+	3	1204	c.994A>G	c.(994-996)AGA>GGA	p.R332G		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	332					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		ACCCAAGGAGAGAGACTTTGT	0.468			NA											12	53					0	0	0.001368	0	0
AADAC	13	broad.mit.edu	37	3	151545806	151545806	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:151545806G>A	uc003eze.2	+	5	1136	c.1046G>A	c.(1045-1047)GGA>GAA	p.G349E		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	349	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AGAGATGATGGACTCATGTAT	0.458	Ovarian(30;839 841 2699 32801 46334)		NA											11	43					0	0	0.008291	0	0
SI	6476	broad.mit.edu	37	3	164735453	164735453	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:164735453G>T	uc003fei.2	-	31	3704	c.3642C>A	c.(3640-3642)GGC>GGA	p.G1214G		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1214	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGACTGGATGGCCAATTACCT	0.318			NA								HNSCC(35;0.089)			5	12					0.00198382	0.00216101	0.001984	1	0
MECOM	2122	broad.mit.edu	37	3	169099123	169099123	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:169099123A>C	uc011bpj.1	-	2	630	c.227T>G	c.(226-228)ATT>AGT	p.I76S	MECOM_uc003ffl.2_Missense_Mutation_p.I48S|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Missense_Mutation_p.I76S|MECOM_uc011bpl.1_Missense_Mutation_p.I76S	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CTCAGCAGGAATGGGGATATC	0.473			NA											25	80					0	0	0.00333	0	0
MASP1	5648	broad.mit.edu	37	3	186943230	186943230	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:186943230G>T	uc003frh.1	-	13	1955	c.1623C>A	c.(1621-1623)CAC>CAA	p.H541Q		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	541	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CATACTGGGGGTGGAGAGTGG	0.547			NA											20	105					1.96292e-10	2.88638e-10	0.010504	1	0
IL1RAP	3556	broad.mit.edu	37	3	190362060	190362060	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:190362060G>T	uc003fsm.1	+	10	1281	c.1075G>T	c.(1075-1077)GAA>TAA	p.E359*	IL1RAP_uc010hzg.1_Nonsense_Mutation_p.E359*|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Nonsense_Mutation_p.E359*|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Nonsense_Mutation_p.E359*	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	359	Extracellular (Potential).				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		ATACACAGTGGAACTGGCTTG	0.473			NA											4	16					0.00909568	0.00963801	0.009096	1	0
FGF12	2257	broad.mit.edu	37	3	191888365	191888365	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:191888365G>A	uc003fsx.2	-	4	1321	c.495C>T	c.(493-495)CGC>CGT	p.R165R	FGF12_uc003fsy.2_Silent_p.R103R	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	165					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		ATTCTTGCTGGCGGTACAGTG	0.393			NA											41	144					0	0	0.00623	0	0
DLG1	1739	broad.mit.edu	37	3	196867097	196867097	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr3:196867097C>A	uc003fxo.3	-	9	916	c.726G>T	c.(724-726)ACG>ACT	p.T242T	DLG1_uc011bub.1_Silent_p.T126T|DLG1_uc011buc.1_Silent_p.T126T|DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Silent_p.T242T|DLG1_uc011bue.1_Silent_p.T209T|DLG1_uc010ial.2_Silent_p.T242T|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Silent_p.T209T|DLG1_uc010ian.2_Silent_p.T109T	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	242	PDZ 1.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GTGGGTTGTCCGTACCTCCTG	0.428			NA											14	49					6.72482e-11	9.93549e-11	0.003163	1	0
PDE6B	5158	broad.mit.edu	37	4	651145	651145	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:651145G>A	uc003gap.2	+	10	1316	c.1263G>A	c.(1261-1263)CTG>CTA	p.L421L	PDE6B_uc003gao.3_Silent_p.L421L|PDE6B_uc011buy.1_Silent_p.L142L|uc003gaq.1_5'Flank	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	421	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						TCCAGTCCCTGACACAGTTCC	0.637	GBM(71;463 1194 9848 25922 46834)		NA											8	22					0	0	0.00308	0	0
WHSC1	7468	broad.mit.edu	37	4	1920134	1920134	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:1920134G>T	uc003gdz.3	+	5	1370	c.1194G>T	c.(1192-1194)AAG>AAT	p.K398N	WHSC1_uc003geb.3_Missense_Mutation_p.K398N|WHSC1_uc003gec.3_Missense_Mutation_p.K398N|WHSC1_uc003ged.3_Missense_Mutation_p.K398N|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.K398N|WHSC1_uc003gdy.1_Missense_Mutation_p.K398N|WHSC1_uc010icd.1_Missense_Mutation_p.K398N|WHSC1_uc003gea.1_Missense_Mutation_p.K398N|WHSC1_uc010ice.1_Missense_Mutation_p.K398N|WHSC1_uc003geh.1_Missense_Mutation_p.K398N	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	398					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TTCCCATGAAGAGAAGGCGGA	0.532			NA	T	IGH@	MM								5	41					0.000602214	0.000670085	0.000602	1	0
RGS12	6002	broad.mit.edu	37	4	3441281	3441281	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:3441281G>T	uc003ggw.2	+	18	5118	c.4214G>T	c.(4213-4215)GGG>GTG	p.G1405V	RGS12_uc003ggz.2_Missense_Mutation_p.G757V|RGS12_uc003gha.2_Missense_Mutation_p.G747V|RGS12_uc010icv.2_Missense_Mutation_p.G604V|HGFAC_uc003ghc.2_5'Flank|HGFAC_uc010icw.2_5'Flank	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1405						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCATAGCGGGGGCACAGGCT	0.662			NA											10	38					2.17888e-05	2.58145e-05	0.006214	1	0
ZBTB49	166793	broad.mit.edu	37	4	4317389	4317389	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:4317389G>A	uc003ghu.2	+	6	1578	c.1403G>A	c.(1402-1404)CGT>CAT	p.R468H	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	468	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						GACGTCCAGCGTCACATTATT	0.403			NA											3	21					0	0	0.004672	0	0
CRMP1	1400	broad.mit.edu	37	4	5862766	5862766	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:5862766C>A	uc003gip.2	-	4	401	c.300G>T	c.(298-300)GGG>GGT	p.G100G	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Silent_p.G100G|CRMP1_uc003gir.2_Silent_p.G95G|CRMP1_uc003gis.2_Silent_p.G214G	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	100					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		TCATCGTGGTCCCGCCCACCA	0.582			NA											6	35					0.00198382	0.00216101	0.001984	1	0
GABRA2	2555	broad.mit.edu	37	4	46264116	46264116	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:46264116G>T	uc003gxc.3	-	8	1559	c.886C>A	c.(886-888)CTA>ATA	p.L296I	GABRA2_uc010igc.2_Missense_Mutation_p.L296I|GABRA2_uc011bzc.1_Missense_Mutation_p.L241I|GABRA2_uc003gxe.2_Missense_Mutation_p.L296I	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	296	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGATGCTTAGAGTTGTCATT	0.418			NA											4	22					0.00024832	0.000280318	0.009096	1	0
UBA6	55236	broad.mit.edu	37	4	68490785	68490785	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:68490785C>A	uc003hdg.3	-	29	2691	c.2639G>T	c.(2638-2640)CGT>CTT	p.R880L		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	880					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TGTTTTGAAACGGTCAGCTGG	0.363			NA											12	33					1.08611e-07	1.43736e-07	0.010729	1	0
CCDC158	339965	broad.mit.edu	37	4	77272874	77272874	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:77272874T>G	uc003hkb.3	-	16	2690	c.2537A>C	c.(2536-2538)AAA>ACA	p.K846T		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	846										skin(3)|ovary(2)|pancreas(1)	6						TGACCTTACTTTTATATCCAA	0.323			NA											6	21					0	0	0.001168	0	0
PRKG2	5593	broad.mit.edu	37	4	82031648	82031648	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:82031648C>A	uc003hmh.2	-	14	1908	c.1894G>T	c.(1894-1896)GAT>TAT	p.D632Y	PRKG2_uc011ccf.1_Missense_Mutation_p.D212Y|PRKG2_uc011ccg.1_Missense_Mutation_p.D212Y|PRKG2_uc011cch.1_Missense_Mutation_p.D603Y	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	632	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GACCAGAAATCCACACTGAAG	0.428			NA											8	35					5.4927e-09	7.69473e-09	0.004482	1	0
AFF1	4299	broad.mit.edu	37	4	88035845	88035845	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:88035845C>T	uc003hqj.3	+	11	2246	c.1839C>T	c.(1837-1839)GCC>GCT	p.A613A	AFF1_uc011ccz.1_Silent_p.A620A|AFF1_uc003hqk.3_Silent_p.A613A|AFF1_uc011cda.1_Silent_p.A251A	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	613						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AGGCCTCTGCCCGGGCAGGTT	0.587			NA											21	51					0	0	0.008871	0	0
UNC5C	8633	broad.mit.edu	37	4	96106324	96106324	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:96106324C>T	uc003htp.1	-	13	2314	c.2160G>A	c.(2158-2160)CAG>CAA	p.Q720Q	UNC5C_uc010ilc.1_Silent_p.Q739Q	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	720	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GTCCTCCCATCTGTCTCTCAA	0.443			NA											15	72					0	0	0.004007	0	0
ADH1A	124	broad.mit.edu	37	4	100212093	100212093	+	Translation_Start_Site	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:100212093G>T	uc003hur.1	-	1	50	c.-21C>A	c.(-23--19)GTCTG>GTATG		uc003hum.1_Splice_Site|ADH1A_uc011ceg.1_Intron|ADH1A_uc010ilg.1_Translation_Start_Site	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit						ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTTCTCTGCAGACCAGGAGAC	0.348			NA											26	64					7.26314e-15	1.18886e-14	0.007291	1	0
C4orf17	84103	broad.mit.edu	37	4	100443848	100443848	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:100443848C>A	uc003huw.2	+	3	642	c.319C>A	c.(319-321)CCT>ACT	p.P107T	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	107											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		TGCCAAAGTGCCTCCACGGCC	0.498			NA											9	49					5.68852e-11	8.42443e-11	0.004482	1	0
ANK2	287	broad.mit.edu	37	4	114278492	114278492	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:114278492G>T	uc003ibe.3	+	38	8818	c.8718G>T	c.(8716-8718)ATG>ATT	p.M2906I	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.M208I|ANK2_uc011cgb.1_Missense_Mutation_p.M2921I	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2873					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GATTTTCCATGGATGTTCCCG	0.398			NA											34	106					2.20474e-14	3.58054e-14	0.003755	1	0
UGT8	7368	broad.mit.edu	37	4	115544302	115544302	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:115544302A>T	uc003ibs.2	+	2	788	c.266A>T	c.(265-267)AAG>ATG	p.K89M	UGT8_uc003ibt.2_Missense_Mutation_p.K89M|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	89					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		CTACAGTCCAAGATGCGGAAT	0.473			NA											19	60					0	0	0.008871	0	0
NDST4	64579	broad.mit.edu	37	4	115998118	115998118	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:115998118G>A	uc003ibu.2	-	2	754	c.75C>T	c.(73-75)AGC>AGT	p.S25S	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	25	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAATGACAATGCTCACCAAGC	0.358			NA											6	20					0	0	0.001168	0	0
SYNPO2	171024	broad.mit.edu	37	4	119978927	119978927	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:119978927C>A	uc010inb.2	+	5	3820	c.3624C>A	c.(3622-3624)TCC>TCA	p.S1208S	SYNPO2_uc011cgh.1_3'UTR|SYNPO2_uc010inc.2_Silent_p.S1078S	NM_133477	NP_597734	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform a	Error:Variant_position_missing_in_Q9UMS6_after_alignment						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						ATAATATGTCCACCACCTCCC	0.413			NA											17	52					1.15088e-07	1.51984e-07	0.004007	1	0
ADAD1	132612	broad.mit.edu	37	4	123317427	123317427	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:123317427G>T	uc003ieo.2	+	7	851	c.619G>T	c.(619-621)GCA>TCA	p.A207S	ADAD1_uc003iep.2_Missense_Mutation_p.A207S|ADAD1_uc003ieq.2_Missense_Mutation_p.A189S	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	207					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TATTCAATATGCAAAGATTTC	0.294			NA											5	23					5.9392e-07	7.61687e-07	0.001168	1	0
PCDH10	57575	broad.mit.edu	37	4	134071464	134071464	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:134071464C>A	uc003iha.2	+	1	995	c.169C>A	c.(169-171)CCC>ACC	p.P57T	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.P57T	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	57	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TCAGACGGTGCCCAACTCAAG	0.527			NA											34	90					4.34311e-12	6.65372e-12	0.003271	1	0
PCDH10	57575	broad.mit.edu	37	4	134072738	134072738	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:134072738C>A	uc003iha.2	+	1	2269	c.1443C>A	c.(1441-1443)TAC>TAA	p.Y481*	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Nonsense_Mutation_p.Y481*	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	481	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CTGGCGCCTACATCTACGCGG	0.602			NA											24	94					2.98393e-07	3.891e-07	0.00278	1	0
OTUD4	54726	broad.mit.edu	37	4	146058708	146058708	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:146058708C>A	uc003ika.3	-	21	3162	c.3024G>T	c.(3022-3024)TGG>TGT	p.W1008C	OTUD4_uc003ijz.3_Missense_Mutation_p.W1007C	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	1072							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					GCTGTCCTTTCCAGGACTCCT	0.473			NA											61	161					4.17052e-40	7.90873e-40	0.00361	1	0
TTC29	83894	broad.mit.edu	37	4	147741356	147741356	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:147741356A>G	uc003ikw.3	-	10	1249	c.1022T>C	c.(1021-1023)GTG>GCG	p.V341A	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.V367A|TTC29_uc010ipd.1_Missense_Mutation_p.V341A	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	341	TPR 4.						binding				0	all_hematologic(180;0.151)					TGCAATTTTCACAAATTTTTT	0.343			NA											11	47					0	0	0.010729	0	0
KIAA0922	23240	broad.mit.edu	37	4	154524568	154524568	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:154524568A>T	uc003inm.3	+	24	2802	c.2750A>T	c.(2749-2751)AAT>ATT	p.N917I	KIAA0922_uc010ipp.2_Missense_Mutation_p.N918I|KIAA0922_uc010ipq.2_Missense_Mutation_p.N686I	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	917	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAGCAAAACAATGGTCCTATG	0.413			NA											7	56					0	0	0.00308	0	0
FGA	2243	broad.mit.edu	37	4	155508744	155508744	+	Nonsense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:155508744T>A	uc003iod.1	-	4	488	c.430A>T	c.(430-432)AAA>TAA	p.K144*	FGA_uc003ioe.1_Nonsense_Mutation_p.K144*|FGA_uc003iof.1_Nonsense_Mutation_p.K144*	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	144	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCTATGACTTTGCGCTTCAGG	0.418	NSCLC(143;340 1922 20892 22370 48145)		NA											16	42					0	0	0.00499	0	0
NPY2R	4887	broad.mit.edu	37	4	156135828	156135828	+	Nonsense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:156135828T>A	uc003ioq.2	+	2	1232	c.737T>A	c.(736-738)TTG>TAG	p.L246*	NPY2R_uc003ior.2_Nonsense_Mutation_p.L246*	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	246	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				TGGAGTAAATTGAAGAACCAT	0.443			NA											14	57					0	0	0.001855	0	0
GLRA3	8001	broad.mit.edu	37	4	175604028	175604028	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:175604028C>T	uc003ity.1	-	6	1140	c.637G>A	c.(637-639)GAA>AAA	p.E213K	GLRA3_uc003itz.1_Missense_Mutation_p.E213K	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	213	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GTGAGTCCTTCTGCCACTTGT	0.368			NA											5	34					0	0	0.000602	0	0
ODZ3	55714	broad.mit.edu	37	4	183713454	183713454	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:183713454C>T	uc003ivd.1	+	25	5666	c.5629C>T	c.(5629-5631)CGG>TGG	p.R1877W		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1877	Extracellular (Potential).|YD 6.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCATAGCCAGCGGCAGTACAT	0.498			NA											20	56					0	0	0.008871	0	0
LRRC14B	389257	broad.mit.edu	37	5	195279	195279	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:195279C>A	uc003jal.1	+	2	1384	c.1356C>A	c.(1354-1356)GAC>GAA	p.D452E		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	452										skin(1)	1						AGAAATACGACGAGATCGCCG	0.592			NA											42	187					4.07013e-28	7.5797e-28	0.00874	1	0
NKD2	85409	broad.mit.edu	37	5	1034410	1034410	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:1034410T>C	uc003jbt.1	+	6	396	c.391T>C	c.(391-393)TAT>CAT	p.Y131H	NKD2_uc010itf.1_Missense_Mutation_p.Y131H	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	131	Targeting to the basolateral cell membrane.|EF-hand.|Interaction with DVL1, DVL2 and DVL3 (By similarity).				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			GTTCACGCTCTATGACTTTGA	0.622			NA											16	67					0	0	0.012319	0	0
IRX4	50805	broad.mit.edu	37	5	1878849	1878849	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:1878849G>T	uc003jcz.2	-	5	913	c.794C>A	c.(793-795)CCG>CAG	p.P265Q	IRX4_uc011cmf.1_Missense_Mutation_p.P126Q	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	265					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		TGCTTCCAGCGGGTCGAAGTC	0.682			NA											17	29					3.41278e-10	4.98298e-10	0.00499	1	0
FBXL7	23194	broad.mit.edu	37	5	15928506	15928506	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:15928506C>A	uc003jfn.1	+	3	1116	c.635C>A	c.(634-636)CCC>CAC	p.P212H		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	212	LRR 2.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CAGTGCTGCCCCGAACTGAGG	0.582			NA											29	55					1.77063e-15	2.94474e-15	0.005443	1	0
PRDM9	56979	broad.mit.edu	37	5	23527395	23527395	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:23527395C>A	uc003jgo.2	+	11	2380	c.2198C>A	c.(2197-2199)TCA>TAA	p.S733*		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	733	C2H2-type 9.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGCAATAAGTCACACCTCCTC	0.582			NA								HNSCC(3;0.000094)			29	135					6.4308e-24	1.17993e-23	0.00361	1	0
CDH9	1007	broad.mit.edu	37	5	26915805	26915805	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:26915805G>C	uc003jgs.1	-	3	625	c.456C>G	c.(454-456)ATC>ATG	p.I152M	CDH9_uc010iug.2_Missense_Mutation_p.I152M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	152	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CATTGTCATTGATATCATGTA	0.373	Melanoma(8;187 585 15745 40864 52829)		NA											49	56					0	0	0.00361	0	0
NPR3	4883	broad.mit.edu	37	5	32780871	32780871	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:32780871T>C	uc003jhv.2	+	5	1457	c.1239T>C	c.(1237-1239)TAT>TAC	p.Y413Y	NPR3_uc010iuo.2_Silent_p.Y197Y|NPR3_uc011cnz.1_Silent_p.Y197Y|NPR3_uc003jhu.2_Silent_p.Y413Y	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	413	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GAGACCGATATGGGGATTTCT	0.552			NA											63	196					0	0	0.00361	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33751635	33751635	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:33751635G>A	uc003jia.1	-	3	671	c.508C>T	c.(508-510)CCA>TCA	p.P170S	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P170S|ADAMTS12_uc003jib.1_Missense_Mutation_p.P170S	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	170					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTCCATGTGGTAGTTGGAAA	0.378			NA								HNSCC(64;0.19)			6	122					0	0	0.00308	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41008745	41008745	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:41008745G>A	uc003jmj.3	-	33	4061	c.3571C>T	c.(3571-3573)CAG>TAG	p.Q1191*	HEATR7B2_uc003jmi.3_Nonsense_Mutation_p.Q746*	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1191	HEAT 13.						binding			ovary(6)|central_nervous_system(2)	8						TCTCCCTGCTGCATCACATGC	0.562			NA											44	61					0	0	0.00361	0	0
NDUFS4	4724	broad.mit.edu	37	5	52979007	52979007	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:52979007G>T	uc003jpe.2	+	5	512	c.484G>T	c.(484-486)GCA>TCA	p.A162S		NM_002495	NP_002486	O43181	NDUS4_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 4	162					brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)	GTCTTATGGTGCAAACTTTTC	0.388			NA											51	66					4.44712e-29	8.30664e-29	0.00361	1	0
MAST4	375449	broad.mit.edu	37	5	66426037	66426037	+	Splice_Site	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:66426037G>T	uc003jut.1	+	14	1247	c.1179_splice	c.e14-1	p.G393_splice	MAST4_uc003juu.1_Splice_Site_p.G403_splice|MAST4_uc011cra.1_Splice_Site_p.G376_splice|MAST4_uc003juv.2_Splice_Site_p.G388_splice|MAST4_uc003juw.2_Splice_Site_p.G388_splice	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase							cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CTCCTTTTCAGGGCAGTCTAC	0.418			NA											3	9					0.004672	0.00502765	0.004672	1	0
BDP1	55814	broad.mit.edu	37	5	70809190	70809190	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:70809190A>G	uc003kbp.1	+	19	4689	c.4426A>G	c.(4426-4428)ATG>GTG	p.M1476V	BDP1_uc003kbo.2_Missense_Mutation_p.M1476V	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1476					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GACTATTGTGATGCAAGAAAA	0.328			NA											9	207					0	0	0.006214	0	0
EDIL3	10085	broad.mit.edu	37	5	83433124	83433124	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:83433124G>T	uc003kio.1	-	5	823	c.404C>A	c.(403-405)ACA>AAA	p.T135K	EDIL3_uc003kip.1_Missense_Mutation_p.T125K	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	135	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AACAAGATCTGTACATATTCC	0.313			NA											12	81					0.000219431	0.000249975	0.00245	1	0
NBPF22P	285622	broad.mit.edu	37	5	85578556	85578556	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:85578556C>A	uc003kiq.2	+	1	295	c.33C>A	c.(31-33)GGC>GGA	p.G11G		NR_003719				SubName: Full=Putative uncharacterized protein NBPF22P;												0						CAGTCCCTGGCTCTACCTCTT	0.463			NA											22	95					0.000229342	0.000260787	0.012319	1	0
APBB3	10307	broad.mit.edu	37	5	139941196	139941196	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:139941196A>T	uc003lgd.1	-	7	1097	c.738T>A	c.(736-738)AGT>AGA	p.S246R	APBB3_uc003lgb.1_Missense_Mutation_p.S18R|APBB3_uc003lgc.1_Missense_Mutation_p.S18R|APBB3_uc003lge.1_Missense_Mutation_p.S239R|APBB3_uc003lgf.1_RNA|APBB3_uc010jfp.1_RNA|APBB3_uc011czi.1_Missense_Mutation_p.S18R|APBB3_uc010jfq.1_Missense_Mutation_p.S18R	NM_133172	NP_573418	O95704	APBB3_HUMAN	amyloid beta precursor protein-binding, family	241	PID 1.					actin cytoskeleton|cytoplasm		p.S248R(1)		ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATGTAGGGCACTGGCAATGG	0.542			NA											78	98					0	0	0.00361	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263343	140263343	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:140263343G>T	uc003lif.2	+	1	1490	c.1490G>T	c.(1489-1491)CGG>CTG	p.R497L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.R497L|PCDHA13_uc003lid.2_Missense_Mutation_p.R497L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	497	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGGAGCGGCGGGTGGGC	0.662	Melanoma(147;1739 1852 5500 27947 37288)		NA											79	48					9.04243e-43	1.72e-42	0.00361	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140784509	140784509	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:140784509A>T	uc003lkh.1	+	1	1990	c.1990A>T	c.(1990-1992)ATA>TTA	p.I664L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.I664L	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	664	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGTAGCCATAGCTGACAG	0.592			NA											44	48					0	0	0.007835	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145969781	145969781	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:145969781A>C	uc003loe.2	-	9	1586	c.1061T>G	c.(1060-1062)ATG>AGG	p.M354R	PPP2R2B_uc010jgm.2_Missense_Mutation_p.M343R|PPP2R2B_uc003log.3_Missense_Mutation_p.M354R|PPP2R2B_uc003lof.3_Missense_Mutation_p.M354R|PPP2R2B_uc003loi.3_Missense_Mutation_p.M357R|PPP2R2B_uc003loh.3_Missense_Mutation_p.M354R|PPP2R2B_uc003loj.3_Missense_Mutation_p.M334R|PPP2R2B_uc003lok.3_Missense_Mutation_p.M343R|PPP2R2B_uc011dbu.1_Missense_Mutation_p.M360R|PPP2R2B_uc011dbv.1_Missense_Mutation_p.M412R	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	354	WD 6.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGAGCCTGTCATGATGACACT	0.473			NA											23	35					0	0	0.00278	0	0
FAT2	2196	broad.mit.edu	37	5	150946570	150946570	+	Silent	SNP	T	T	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:150946570T>G	uc003lue.3	-	1	1936	c.1923A>C	c.(1921-1923)ACA>ACC	p.T641T	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.T641T	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	641	Extracellular (Potential).|Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATCTGAGGCTGTAATCTTCA	0.413			NA											25	24					0	0	0.003954	0	0
KIF4B	285643	broad.mit.edu	37	5	154394885	154394885	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:154394885A>G	uc010jih.1	+	1	1626	c.1466A>G	c.(1465-1467)GAT>GGT	p.D489G		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	489	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCAGCCATTGATACTGCGGTA	0.453			NA											37	60					0	0	0.005524	0	0
KIF4B	285643	broad.mit.edu	37	5	154396536	154396536	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:154396536G>C	uc010jih.1	+	1	3277	c.3117G>C	c.(3115-3117)ATG>ATC	p.M1039I		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1039	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGCAAAGCATGGACATCGAGG	0.343			NA											35	33					0	0	0.002836	0	0
DOCK2	1794	broad.mit.edu	37	5	169129338	169129338	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:169129338C>T	uc003maf.2	+	14	1370	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_5'Flank|DOCK2_uc010jjl.1_5'UTR	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	430	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATTACTCTCTTACAAGGTG	0.493			NA									OREG0017017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	114					0	0	0.001168	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171777438	171777438	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:171777438T>A	uc003mbr.2	-	10	1112	c.941A>T	c.(940-942)AAG>ATG	p.K314M		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	314					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGCAGCTCCTTCTCCCTGCC	0.677			NA											34	28					0	0	0.012213	0	0
SLC34A1	6569	broad.mit.edu	37	5	176823992	176823992	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:176823992C>A	uc003mgk.3	+	12	1434	c.1333C>A	c.(1333-1335)CTG>ATG	p.L445M		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	445	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCGCTCACACTGGGTTCCAA	0.647			NA											30	27					1.68575e-08	2.30448e-08	0.007291	1	0
SERPINB9	5272	broad.mit.edu	37	6	2892184	2892184	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:2892184G>A	uc003mug.2	-	6	727	c.606C>T	c.(604-606)GCC>GCT	p.A202A	uc003mue.2_Intron|SERPINB9_uc003muf.2_Silent_p.A5A	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	202					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GCTTAAACGTGGCCTCCTGAT	0.577			NA											8	115					0	0	0.006214	0	0
HIVEP1	3096	broad.mit.edu	37	6	12124237	12124237	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:12124237A>T	uc003nac.2	+	4	4388	c.4209A>T	c.(4207-4209)GAA>GAT	p.E1403D	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1403					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CACTTACTGAATTGCAGCCTC	0.478			NA											4	105					0	0	0.000602	0	0
TDP2	51567	broad.mit.edu	37	6	24651078	24651078	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:24651078C>A	uc003nej.2	-	7	1052	c.1027G>T	c.(1027-1029)GAC>TAC	p.D343Y	TDP2_uc003nei.2_Missense_Mutation_p.D231Y	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	343					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						CTACCACAGTCCAGTTTTTCT	0.398			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					8	52					3.09899e-07	3.99083e-07	0.004482	1	0
SCAND3	114821	broad.mit.edu	37	6	28539765	28539765	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:28539765G>A	uc003nlo.2	-	4	4519	c.3901C>T	c.(3901-3903)CTG>TTG	p.L1301L		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1301					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						gctaccctcaggggataatgt	0			NA											17	45					0	0	0.004007	0	0
TRIM27	5987	broad.mit.edu	37	6	28872429	28872429	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:28872429C>G	uc003nlr.2	-	8	1319	c.960G>C	c.(958-960)CTG>CTC	p.L320L	TRIM27_uc003nls.2_Silent_p.L320L|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	320	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TGTCTGGGTCCAGAGTCACGT	0.557			NA	T	RET	papillary thyroid								7	39					0	0	0.001984	0	0
OR14J1	442191	broad.mit.edu	37	6	29274893	29274893	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:29274893G>T	uc011dln.1	+	1	427	c.427G>T	c.(427-429)GTG>TTG	p.V143L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TAGGCATGCAGTGATAGCTGT	0.488			NA											100	105					1.7666e-45	3.381e-45	0.00361	1	0
KIAA1949	170954	broad.mit.edu	37	6	30653751	30653751	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:30653751G>T	uc003nra.2	-	2	276	c.45C>A	c.(43-45)CGC>CGA	p.R15R	KIAA1949_uc003nrb.3_Silent_p.R15R	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	15						cytoplasm|cytoskeleton	actin binding				0						CCTCCTGCCGGCGCCGGGCTA	0.662			NA											45	186					2.0833e-19	3.70232e-19	0.00361	1	0
BAT2	7916	broad.mit.edu	37	6	31600360	31600360	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:31600360G>T	uc003nvb.3	+	16	4159	c.3910G>T	c.(3910-3912)GCC>TCC	p.A1304S	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.A1304S	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1304	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CCGGGCAGCTGCCAAGTCTCC	0.607			NA											23	127					2.32416e-17	3.9715e-17	0.002299	1	0
NOTCH4	4855	broad.mit.edu	37	6	32180263	32180263	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:32180263C>A	uc003obb.2	-	17	2807	c.2668G>T	c.(2668-2670)GCA>TCA	p.A890S	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	890	EGF-like 23.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TGGCTCAGTGCAGCCTTCTGG	0.587			NA											109	76					4.44732e-65	8.53776e-65	0.00361	1	0
TAP1	6890	broad.mit.edu	37	6	32816584	32816584	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:32816584C>A	uc003ocg.2	-	7	1746	c.1591G>T	c.(1591-1593)GCT>TCT	p.A531S	TAP1_uc011dqi.1_Missense_Mutation_p.A270S	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	531	Involved in peptide-binding site.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						GAGCCCACAGCCTTCTGTACT	0.527			NA											43	42					1.97e-11	2.97413e-11	0.010771	1	0
COL11A2	1302	broad.mit.edu	37	6	33151934	33151934	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:33151934G>T	uc003ocx.1	-	8	1335	c.1107C>A	c.(1105-1107)GCC>GCA	p.A369A	COL11A2_uc003ocy.1_Intron|COL11A2_uc003ocz.1_Intron	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	369	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CTCCTGAGTGGGCTGTCTCCG	0.532	Melanoma(1;90 116 3946 5341 17093)		NA											6	119					0.00116845	0.0012886	0.001168	1	0
KCNK16	83795	broad.mit.edu	37	6	39282878	39282878	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:39282878G>T	uc003ooq.2	-	6	844	c.830C>A	c.(829-831)GCG>GAG	p.A277E	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_3'UTR|KCNK16_uc010jwy.2_Missense_Mutation_p.A230E	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	277	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						GCCTGGAGCCGCCTTGGCTCC	0.572			NA											31	127					2.47316e-13	3.93428e-13	0.003271	1	0
CRIP3	401262	broad.mit.edu	37	6	43275482	43275482	+	Splice_Site	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:43275482C>A	uc010jyn.1	-	4	197	c.197_splice	c.e4-1	p.G66_splice	CRIP3_uc003ouu.1_Splice_Site_p.G66_splice	NM_206922	NP_996805	Q6Q6R5	CRIP3_HUMAN	cysteine-rich protein 3							cytoplasm	zinc ion binding			skin(1)	1			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			ATGTTCACCCCTGAAGAGAGA	0.612			NA											20	62					2.4624e-09	3.48093e-09	0.008871	1	0
YIPF3	25844	broad.mit.edu	37	6	43480928	43480928	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:43480928G>T	uc003ovl.1	-	6	702	c.545C>A	c.(544-546)ACC>AAC	p.T182N	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Missense_Mutation_p.T147N|YIPF3_uc010jyr.1_Missense_Mutation_p.T188N|YIPF3_uc010jys.1_Missense_Mutation_p.T25N|YIPF3_uc003ovm.1_Missense_Mutation_p.T56N|YIPF3_uc010jyt.1_Missense_Mutation_p.T131N	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	182					cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCCCATCAGGGTGCCCTCCCG	0.587			NA											44	135					6.21074e-16	1.04126e-15	0.011902	1	0
PGK2	5232	broad.mit.edu	37	6	49754702	49754702	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:49754702G>T	uc003ozu.2	-	1	306	c.199C>A	c.(199-201)CCT>ACT	p.P67T		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	67					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					ACACCATCAGGCCGACCTAGA	0.483			NA											42	62					2.54651e-27	4.71407e-27	0.006999	1	0
DST	667	broad.mit.edu	37	6	56819367	56819367	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:56819367G>T	uc003pdf.2	-	1	47	c.19C>A	c.(19-21)CTC>ATC	p.L7I	BEND6_uc010kab.2_5'Flank|BEND6_uc003pdg.2_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGCAAGACGAGGAAAGCCGCG	0.682			NA											7	14					8.12818e-05	9.34516e-05	0.001984	1	0
BEND6	221336	broad.mit.edu	37	6	56880084	56880084	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:56880084C>T	uc010kab.2	+	4	1038	c.452C>T	c.(451-453)TCT>TTT	p.S151F	BEND6_uc003pdi.3_Missense_Mutation_p.S53F	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	151											0						TGCAGTAATTCTAATTCTAAC	0.458			NA											20	23					0	0	0.008871	0	0
BAI3	577	broad.mit.edu	37	6	70071353	70071353	+	Silent	SNP	A	A	T	rs144565451	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:70071353A>T	uc003pev.3	+	29	4636	c.4188A>T	c.(4186-4188)GCA>GCT	p.A1396A	BAI3_uc010kak.2_Silent_p.A1396A|BAI3_uc011dxx.1_Silent_p.A602A	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1396	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATGATAATGCAGGACTATCAA	0.403			NA											19	34					0	0	0.008871	0	0
RIMS1	22999	broad.mit.edu	37	6	73102455	73102455	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:73102455G>T	uc003pga.2	+	31	4638	c.4561G>T	c.(4561-4563)GAT>TAT	p.D1521Y	RIMS1_uc011dyb.1_Missense_Mutation_p.D918Y|RIMS1_uc003pgc.2_Missense_Mutation_p.D970Y|RIMS1_uc010kaq.2_Missense_Mutation_p.D841Y|RIMS1_uc011dyc.1_Missense_Mutation_p.D646Y|RIMS1_uc010kar.2_Missense_Mutation_p.D589Y|RIMS1_uc011dyd.1_Missense_Mutation_p.D655Y|RIMS1_uc003pgf.2_Missense_Mutation_p.D521Y|RIMS1_uc003pgg.2_Missense_Mutation_p.D417Y|RIMS1_uc003pgi.2_Missense_Mutation_p.D337Y|RIMS1_uc003pgh.2_Missense_Mutation_p.D388Y|RIMS1_uc003pgd.2_Missense_Mutation_p.D587Y|RIMS1_uc003pge.2_Missense_Mutation_p.D561Y|RIMS1_uc011dye.1_Missense_Mutation_p.D327Y|RIMS1_uc011dyf.1_Missense_Mutation_p.D145Y|RIMS1_uc011dyg.1_Missense_Mutation_p.D48Y	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1521					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGATTTTCTTGATGGATTGGG	0.408			NA											19	43					2.89027e-11	4.31114e-11	0.002299	1	0
CNR1	1268	broad.mit.edu	37	6	88853946	88853946	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:88853946C>G	uc011dzq.1	-	2	4611	c.1048G>C	c.(1048-1050)GTG>CTG	p.V350L	CNR1_uc010kbz.2_Missense_Mutation_p.V350L|CNR1_uc011dzr.1_Missense_Mutation_p.V350L|CNR1_uc011dzs.1_Missense_Mutation_p.V350L|CNR1_uc003pmq.3_Missense_Mutation_p.V350L|CNR1_uc011dzt.1_Missense_Mutation_p.V350L|CNR1_uc010kca.2_Missense_Mutation_p.V317L	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	350	Helical; Name=6; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding	p.V350V(1)		skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ATCAACACCACCAGGATCAGG	0.522			NA											5	120					0	0	0.001168	0	0
CLVS2	134829	broad.mit.edu	37	6	123332140	123332140	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:123332140G>A	uc003pzi.1	+	3	1269	c.400G>A	c.(400-402)GTG>ATG	p.V134M		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	134	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GTACACACTGGTGGATATTTT	0.363			NA											27	50					0	0	0.007291	0	0
LAMA2	3908	broad.mit.edu	37	6	129762043	129762043	+	Silent	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:129762043A>G	uc003qbn.2	+	43	6273	c.6168A>G	c.(6166-6168)ACA>ACG	p.T2056T	LAMA2_uc003qbo.2_Silent_p.T2056T	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2056	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CACAGATTACAGAGCTCCACC	0.463			NA											11	25					0	0	0.010729	0	0
HIVEP2	3097	broad.mit.edu	37	6	143091866	143091866	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:143091866C>T	uc003qjd.2	-	5	4753	c.4010G>A	c.(4009-4011)CGG>CAG	p.R1337Q		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CGTCTGGATCCGAACAGGAAC	0.488	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											15	66					0	0	0.00245	0	0
GRM1	2911	broad.mit.edu	37	6	146351126	146351126	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:146351126G>A	uc010khw.1	+	2	943	c.473G>A	c.(472-474)GGA>GAA	p.G158E	GRM1_uc010khu.1_Missense_Mutation_p.G158E|GRM1_uc010khv.1_Missense_Mutation_p.G158E|GRM1_uc003qll.2_Missense_Mutation_p.G158E|GRM1_uc011edz.1_Missense_Mutation_p.G158E|GRM1_uc011eea.1_Missense_Mutation_p.G158E	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	158	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCATTGCGGGAGTGATCGGT	0.572			NA											4	81					0	0	0.009096	0	0
GRM1	2911	broad.mit.edu	37	6	146719925	146719925	+	Missense_Mutation	SNP	C	C	T	rs146996893		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:146719925C>T	uc010khw.1	+	8	2220	c.1750C>T	c.(1750-1752)CGC>TGC	p.R584C	GRM1_uc010khv.1_Missense_Mutation_p.R584C|GRM1_uc003qll.2_Missense_Mutation_p.R584C|GRM1_uc011edz.1_Missense_Mutation_p.R584C|GRM1_uc011eea.1_Missense_Mutation_p.R584C	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	584	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CATTCCTGTGCGCTATCTTGA	0.423			NA											7	174					0	0	0.001984	0	0
PARK2	5071	broad.mit.edu	37	6	162683678	162683678	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:162683678C>A	uc003qtx.3	-	3	425	c.291G>T	c.(289-291)CGG>CGT	p.R97R	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Intron|PARK2_uc003qtw.3_5'UTR|PARK2_uc003qty.3_Silent_p.R97R|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Silent_p.R97R	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	97					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TCTGGGGCTCCCGCTCACAGC	0.582			NA											22	56					3.5997e-14	5.81562e-14	0.002299	1	0
THBS2	7058	broad.mit.edu	37	6	169640673	169640673	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:169640673C>A	uc003qwt.2	-	7	1154	c.906G>T	c.(904-906)CAG>CAT	p.Q302H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	302					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCCAGAGAAACTGGTTATCAT	0.433	Esophageal Squamous(91;219 1934 18562 44706)		NA											7	32					0.00198382	0.00216101	0.001984	1	0
CARD11	84433	broad.mit.edu	37	7	2976714	2976714	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:2976714C>G	uc003smv.2	-	9	1702	c.1298G>C	c.(1297-1299)AGC>ACC	p.S433T		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	433	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCGCAGCTTGCTCTCCAGGTT	0.642			NA	Mis		DLBCL								21	47					0	0	0.002299	0	0
RNF216	54476	broad.mit.edu	37	7	5760761	5760761	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:5760761T>A	uc003soy.1	-	9	1566	c.1376A>T	c.(1375-1377)AAG>ATG	p.K459M	RNF216_uc010ksz.1_Missense_Mutation_p.K81M|RNF216_uc010kta.1_Missense_Mutation_p.K81M|RNF216_uc011jwj.1_Missense_Mutation_p.K81M|RNF216_uc003sox.1_Missense_Mutation_p.K516M	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	459					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		ATGTCGTCGCTTATTTTCAAG	0.428			NA											29	62					0	0	0.005443	0	0
HDAC9	9734	broad.mit.edu	37	7	18688117	18688117	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:18688117C>T	uc003suh.2	+	10	1310	c.1269C>T	c.(1267-1269)CCC>CCT	p.P423P	HDAC9_uc003sue.2_Silent_p.P423P|HDAC9_uc011jyd.1_Silent_p.P423P|HDAC9_uc003sui.2_Silent_p.P426P|HDAC9_uc003suj.2_Silent_p.P382P|HDAC9_uc011jya.1_Silent_p.P420P|HDAC9_uc003sua.1_Silent_p.P401P|HDAC9_uc011jyb.1_Silent_p.P379P|HDAC9_uc003sud.1_Silent_p.P423P|HDAC9_uc011jyc.1_Silent_p.P382P|HDAC9_uc003suf.1_Silent_p.P454P|HDAC9_uc010kud.1_Silent_p.P426P|HDAC9_uc011jye.1_Silent_p.P395P|HDAC9_uc011jyf.1_Silent_p.P346P|HDAC9_uc010kue.1_Silent_p.P166P	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	423					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CTCAGTCTCCCTTGGCAACAA	0.368			NA											18	98					0	0	0.008871	0	0
DNAH11	8701	broad.mit.edu	37	7	21784546	21784546	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:21784546G>C	uc003svc.2	+	52	8427	c.8396G>C	c.(8395-8397)AGA>ACA	p.R2799T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2799					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTTGCTGATAGAGGGAAGGAC	0.443			NA							Kartagener_syndrome				7	17					0	0	0.001984	0	0
HOXA5	3202	broad.mit.edu	37	7	27182927	27182927	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:27182927C>A	uc003syn.1	-	1	361	c.300G>T	c.(298-300)CCG>CCT	p.P100P		NM_019102	NP_061975	P20719	HXA5_HUMAN	homeobox A5	100					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGCAGGGCAGCGGATCGGGCT	0.751	Colon(119;75 2200 7557 42868)		NA											10	21					7.48243e-07	9.55661e-07	0.006214	1	0
GPR141	353345	broad.mit.edu	37	7	37780847	37780847	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:37780847C>T	uc003tfm.1	+	1	852	c.852C>T	c.(850-852)GTC>GTT	p.V284V	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	284	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TTCTCTTTGTCTTTGGGGGAA	0.378			NA											18	59					0	0	0.00499	0	0
POU6F2	11281	broad.mit.edu	37	7	39247051	39247051	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:39247051C>A	uc003thb.1	+	4	385	c.343C>A	c.(343-345)CCA>ACA	p.P115T	POU6F2_uc010kxo.2_Missense_Mutation_p.P107T	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	115					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						GGGAGGCCCCCCAGCCCTCAA	0.577			NA											71	201					1.45978e-39	2.75983e-39	0.00361	1	0
HECW1	23072	broad.mit.edu	37	7	43447293	43447293	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:43447293T>A	uc003tid.1	+	8	1369	c.764T>A	c.(763-765)ATC>AAC	p.I255N	HECW1_uc011kbi.1_Missense_Mutation_p.I255N|HECW1_uc003tie.1_Missense_Mutation_p.I287N	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	255	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGATCCAAGATCATAGGCAAC	0.527			NA											18	35					0	0	0.002299	0	0
HECW1	23072	broad.mit.edu	37	7	43484732	43484732	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:43484732C>A	uc003tid.1	+	11	2566	c.1961C>A	c.(1960-1962)ACC>AAC	p.T654N	HECW1_uc011kbi.1_Missense_Mutation_p.T654N	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	654					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CACCCCAGCACCGGGAGCGAG	0.721			NA											20	30					4.96729e-08	6.65874e-08	0.008871	1	0
NPC1L1	29881	broad.mit.edu	37	7	44560608	44560608	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:44560608G>A	uc003tlb.2	-	13	3119	c.3063C>T	c.(3061-3063)AAC>AAT	p.N1021N	NPC1L1_uc003tlc.2_Silent_p.N1021N|NPC1L1_uc011kbw.1_Silent_p.N975N|NPC1L1_uc003tla.2_Silent_p.N24N	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1021	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GACATTTGATGTTGGGCCGGT	0.552			NA											68	183					0	0	0.00361	0	0
ADCY1	107	broad.mit.edu	37	7	45650033	45650033	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:45650033A>G	uc003tne.3	+	3	863	c.845A>G	c.(844-846)GAC>GGC	p.D282G	ADCY1_uc003tnd.2_Missense_Mutation_p.D57G	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	282	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ATGAAGGAGGACTTCCTGAAG	0.612			NA											43	117					0	0	0.00361	0	0
ZPBP	11055	broad.mit.edu	37	7	50023026	50023026	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:50023026T>C	uc003tou.2	-	7	943	c.873A>G	c.(871-873)GAA>GAG	p.E291E	ZPBP_uc011kci.1_Silent_p.E217E|ZPBP_uc010kyw.2_Silent_p.E290E	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	291					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					GGAGAGTACCTTCAATATAGT	0.353			NA											11	26					0	0	0.010729	0	0
AUTS2	26053	broad.mit.edu	37	7	70255379	70255379	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:70255379G>T	uc003tvw.3	+	19	3920	c.3177G>T	c.(3175-3177)GAG>GAT	p.E1059D	AUTS2_uc003tvx.3_Missense_Mutation_p.E1035D|AUTS2_uc011keg.1_Missense_Mutation_p.E511D	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1059										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CGGGCGGAGAGCGCTTCCCGT	0.632			NA											7	27					5.18039e-06	6.35543e-06	0.00308	1	0
ABCB1	5243	broad.mit.edu	37	7	87160794	87160794	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:87160794G>A	uc003uiz.1	-	22	2919	c.2501C>T	c.(2500-2502)GCT>GTT	p.A834V	ABCB1_uc011khc.1_Missense_Mutation_p.A770V	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	834	Helical; (Potential).|ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GGTAATTACAGCAAGCCTGGA	0.343			NA											15	29					0	0	0.00245	0	0
GTPBP10	85865	broad.mit.edu	37	7	89982211	89982211	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:89982211G>T	uc003ukm.1	+	2	181	c.115G>T	c.(115-117)GGT>TGT	p.G39C	GTPBP10_uc003uki.1_Missense_Mutation_p.G56C|GTPBP10_uc003ukj.1_Missense_Mutation_p.G30C|GTPBP10_uc003ukk.1_RNA|GTPBP10_uc003ukl.1_RNA|GTPBP10_uc003ukn.1_Missense_Mutation_p.G39C|GTPBP10_uc003uko.1_Translation_Start_Site	NM_033107	NP_149098	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 isoform 2	39					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding				0						AGGTGGAGAAGGTGGAAAAGG	0.433			NA											16	28					6.94344e-10	1.00438e-09	0.006122	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95726882	95726882	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:95726882G>T	uc003uoc.3	+	17	2192	c.1915G>T	c.(1915-1917)GGC>TGC	p.G639C	DYNC1I1_uc003uod.3_Missense_Mutation_p.G622C|DYNC1I1_uc003uob.2_Missense_Mutation_p.G602C|DYNC1I1_uc003uoe.3_Missense_Mutation_p.G619C|DYNC1I1_uc010lfl.2_Missense_Mutation_p.G628C	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	639					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CGAGGAGGAAGGCACTGTTGA	0.512			NA											14	47					1.49906e-05	1.80003e-05	0.00245	1	0
STAG3	10734	broad.mit.edu	37	7	99809090	99809090	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:99809090G>T	uc003utx.1	+	31	3598	c.3443G>T	c.(3442-3444)AGG>ATG	p.R1148M	STAG3_uc011kjk.1_Missense_Mutation_p.R1090M|GATS_uc003uty.3_RNA|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|STAG3_uc003uub.1_Missense_Mutation_p.R373M|GATS_uc011kjl.1_RNA|GATS_uc010lgu.2_RNA	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	1148					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAGAGGTCAAGGTTCTTGGGT	0.517			NA											48	135					3.10996e-30	5.8441e-30	0.00361	1	0
ZAN	7455	broad.mit.edu	37	7	100361433	100361433	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:100361433C>G	uc003uwj.2	+	21	4156	c.3991C>G	c.(3991-3993)CAG>GAG	p.Q1331E	ZAN_uc003uwk.2_Missense_Mutation_p.Q1331E|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1331	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGCAGGTGTCAGAAGTACCA	0.597			NA											6	117					0	0	0.001984	0	0
MUC17	140453	broad.mit.edu	37	7	100696348	100696348	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:100696348G>A	uc003uxp.1	+	10	13238	c.13185G>A	c.(13183-13185)GTG>GTA	p.V4395V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4395	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACGGCCTCGTGGGGGCAGGGG	0.597			NA											13	64					0	0	0.001368	0	0
LRWD1	222229	broad.mit.edu	37	7	102108574	102108574	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:102108574G>T	uc003uzn.2	+	6	882	c.744G>T	c.(742-744)GCG>GCT	p.A248A	LRWD1_uc003uzo.2_Silent_p.A96A	NM_152892	NP_690852	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain	248					chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			skin(1)	1						GCAAGCGGGCGTGTGCCTCCC	0.682			NA											3	18					0.004672	0.00502765	0.004672	1	0
RELN	5649	broad.mit.edu	37	7	103205900	103205900	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:103205900A>T	uc003vca.2	-	34	5195	c.5035T>A	c.(5035-5037)TCC>ACC	p.S1679T	RELN_uc010liz.2_Missense_Mutation_p.S1679T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1679					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACACTGTGGGAGTTGCTGAAG	0.478	NSCLC(146;835 1944 15585 22231 52158)		NA											7	22					0	0	0.001984	0	0
COG5	10466	broad.mit.edu	37	7	107204403	107204403	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:107204403G>T	uc003ved.2	-	1	557	c.32C>A	c.(31-33)TCT>TAT	p.S11Y	COG5_uc003vec.2_Missense_Mutation_p.S11Y|COG5_uc003vee.2_Missense_Mutation_p.S11Y|DUS4L_uc003veg.2_5'Flank|DUS4L_uc003veh.2_5'Flank|DUS4L_uc011klw.1_5'Flank|DUS4L_uc011klx.1_5'Flank	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	11					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TGGTGACGCAGAATCCCGGCG	0.701			NA											7	14					3.09899e-07	3.99083e-07	0.004482	1	0
DOCK4	9732	broad.mit.edu	37	7	111430661	111430661	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:111430661C>A	uc003vfx.2	-	31	3436	c.3167G>T	c.(3166-3168)GGA>GTA	p.G1056V	DOCK4_uc011kmm.1_5'Flank|DOCK4_uc003vfw.2_Missense_Mutation_p.G497V|DOCK4_uc003vfy.2_Missense_Mutation_p.G1092V	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1056					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTTGTGCTCTCCTAAAGTGAG	0.323			NA											7	17					8.12818e-05	9.34516e-05	0.001984	1	0
C7orf58	79974	broad.mit.edu	37	7	120884330	120884330	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:120884330C>A	uc003vjq.3	+	18	2695	c.2248C>A	c.(2248-2250)CAC>AAC	p.H750N	C7orf58_uc003vjs.3_Missense_Mutation_p.H750N|C7orf58_uc003vjt.3_Missense_Mutation_p.H530N	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	750						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CTGGCAGCCCCACAACTGCCA	0.493			NA											22	60					7.45023e-12	1.13858e-11	0.010504	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121651931	121651931	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:121651931A>G	uc003vjy.2	+	12	3226	c.2831A>G	c.(2830-2832)TAC>TGC	p.Y944C	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	944	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACTGTTTCTTACAGTTCTGCA	0.453			NA											32	89					0	0	0.012213	0	0
IMPDH1	3614	broad.mit.edu	37	7	128034398	128034398	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:128034398C>T	uc011kol.1	-	13	1563	c.1457G>A	c.(1456-1458)GGA>GAA	p.G486E	IMPDH1_uc011kom.1_Missense_Mutation_p.G481E|IMPDH1_uc003vmt.2_Missense_Mutation_p.G461E|IMPDH1_uc003vmu.2_Missense_Mutation_p.G571E|IMPDH1_uc003vmw.2_Missense_Mutation_p.G561E|IMPDH1_uc011kon.1_Missense_Mutation_p.G538E|IMPDH1_uc003vmv.2_Missense_Mutation_p.G535E|IMPDH1_uc003vmx.2_Missense_Mutation_p.G494E|IMPDH1_uc003vmy.2_Missense_Mutation_p.G502E|uc011koo.1_5'Flank	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	486					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CTTGAGCTCTCCTGAGTACAT	0.577			NA											8	81					0	0	0.004482	0	0
FLNC	2318	broad.mit.edu	37	7	128488078	128488078	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:128488078C>T	uc003vnz.3	+	26	4745	c.4536C>T	c.(4534-4536)CCC>CCT	p.P1512P	FLNC_uc003voa.3_Silent_p.P1512P	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1512	Filamin 13.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CTGACGGGCCCTACACGGTAG	0.662			NA											6	12					0	0	0.001168	0	0
TRYX3	136541	broad.mit.edu	37	7	141952344	141952344	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:141952344G>T	uc003vxb.2	-	4	844	c.524C>A	c.(523-525)ACG>AAG	p.T175K	TRYX3_uc003vxc.3_Missense_Mutation_p.T175K	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	175	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					CATATTTTCCGTGATGTTGTA	0.433			NA											28	75					1.88708e-17	3.23352e-17	0.008361	1	0
TRPV5	56302	broad.mit.edu	37	7	142627152	142627152	+	Splice_Site	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:142627152C>A	uc003wby.1	-	3	613	c.349_splice	c.e3+1	p.G117_splice	TRPV5_uc003wbz.2_Splice_Site_p.G117_splice	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,						protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					AGGCTCCTTACCTGCAAAAGC	0.537			NA											35	86					1.36161e-19	2.43369e-19	0.004289	1	0
OR6B1	135946	broad.mit.edu	37	7	143701161	143701161	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:143701161G>T	uc003wdt.1	+	1	72	c.72G>T	c.(70-72)CGG>CGT	p.R24R		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TGAGTATGCGGGCAGCCATGT	0.502			NA											19	41					3.8784e-16	6.51991e-16	0.012319	1	0
OR2A5	393046	broad.mit.edu	37	7	143748127	143748127	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:143748127C>G	uc011ktw.1	+	1	633	c.633C>G	c.(631-633)CTC>CTG	p.L211L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGGGGCCGCTCTGCCTGGTGC	0.602			NA											69	172					0	0	0.00361	0	0
EZH2	2146	broad.mit.edu	37	7	148515173	148515173	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:148515173C>T	uc003wfd.1	-	10	1187	c.1021G>A	c.(1021-1023)GAG>AAG	p.E341K	EZH2_uc011kug.1_Missense_Mutation_p.E332K|EZH2_uc003wfb.1_Missense_Mutation_p.E346K|EZH2_uc003wfc.1_Missense_Mutation_p.E302K|EZH2_uc011kuh.1_Missense_Mutation_p.E332K|EZH2_uc011kui.1_Missense_Mutation_p.E341K|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	341					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TTTATCCGCTCAGCGGTGAGA	0.498			NA	Mis		DLBCL								15	149					0	0	0.00245	0	0
SSPO	23145	broad.mit.edu	37	7	149491894	149491894	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:149491894C>A	uc010lpk.2	+	42	6095	c.6095C>A	c.(6094-6096)ACG>AAG	p.T2032K		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2032					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGAACCAGACGGTCCAGCCC	0.617			NA											13	72					2.68362e-12	4.12151e-12	0.001368	1	0
DPP6	1804	broad.mit.edu	37	7	154172070	154172070	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:154172070T>C	uc003wlk.2	+	3	534	c.405T>C	c.(403-405)GAT>GAC	p.D135D	DPP6_uc003wli.2_Silent_p.D71D|DPP6_uc003wlj.2_Silent_p.D135D|DPP6_uc010lqh.1_Silent_p.D73D|DPP6_uc003wlm.2_Silent_p.D73D|DPP6_uc011kvq.1_Silent_p.D73D	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	135	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CTGTAGAAGATCTCTTCAGTG	0.403	NSCLC(125;1384 1783 2490 7422 34254)		NA											7	60					0	0	0.001984	0	0
MYOM2	9172	broad.mit.edu	37	8	2046747	2046747	+	Missense_Mutation	SNP	G	G	T	rs34863717	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:2046747G>T	uc003wpx.3	+	19	2512	c.2374G>T	c.(2374-2376)GGC>TGC	p.G792C	MYOM2_uc011kwi.1_Missense_Mutation_p.G217C	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	792	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CAACCTGGCCGGCATCGGGGA	0.562			NA											5	13					0.000602214	0.000670085	0.000602	1	0
CSMD1	64478	broad.mit.edu	37	8	3443742	3443742	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:3443742C>A	uc011kwk.1	-	9	1531	c.1141G>T	c.(1141-1143)GTG>TTG	p.V381L		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	381	Extracellular (Potential).|Sushi 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCTGGAGCACGTAATTGTCC	0.448			NA											3	12					0.004672	0.00502765	0.004672	1	0
CHRNB3	1142	broad.mit.edu	37	8	42586918	42586918	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:42586918C>G	uc003xpi.1	+	5	596	c.468C>G	c.(466-468)GAC>GAG	p.D156E		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	156	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCACCATGGACGTCACGTTTT	0.507			NA											8	46					0	0	0.00308	0	0
CPA6	57094	broad.mit.edu	37	8	68421816	68421816	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:68421816G>A	uc003xxq.3	-	5	726	c.470C>T	c.(469-471)TCA>TTA	p.S157L	CPA6_uc003xxr.3_Missense_Mutation_p.S9L|CPA6_uc003xxs.2_Missense_Mutation_p.S157L	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	157					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AATGAGGCCTGAGTGAGTTTT	0.303			NA											11	42					0	0	0.001368	0	0
PRDM14	63978	broad.mit.edu	37	8	70981566	70981566	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:70981566T>A	uc003xym.2	-	2	732	c.530A>T	c.(529-531)CAG>CTG	p.Q177L		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			ATCCTCTGACTGCTTGCTGGG	0.567	NSCLC(129;99 1813 5906 40656 46114)		NA											17	42					0	0	0.004007	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766126	77766126	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:77766126G>A	uc003yav.2	+	10	7221	c.6834G>A	c.(6832-6834)AGG>AGA	p.R2278R	ZFHX4_uc003yau.1_Silent_p.R2323R|ZFHX4_uc003yaw.1_Silent_p.R2278R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2278	C2H2-type 15; degenerate.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTTCCCCAGGATCTTTGACT	0.398			NA								HNSCC(33;0.089)			24	95					0	0	0.002299	0	0
PEX2	5828	broad.mit.edu	37	8	77895700	77895700	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:77895700T>A	uc003yax.2	-	4	1173	c.715A>T	c.(715-717)ACC>TCC	p.T239S	PEX2_uc003yay.2_Missense_Mutation_p.T239S|PEX2_uc003yaz.2_Missense_Mutation_p.T239S	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	239					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						TTGCCACTGGTGGCTAATGTA	0.428			NA											7	78					0	0	0.001984	0	0
CNGB3	54714	broad.mit.edu	37	8	87679339	87679339	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:87679339G>T	uc003ydx.2	-	6	712	c.666C>A	c.(664-666)CTC>CTA	p.L222L	CNGB3_uc010maj.2_Silent_p.L84L	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	222	Helical; Name=H1; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TGACAAGCAAGAGCCACAGGA	0.438			NA											11	34					5.50884e-06	6.74507e-06	0.001368	1	0
CDH17	1015	broad.mit.edu	37	8	95189922	95189922	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:95189922A>C	uc003ygh.2	-	4	303	c.178T>G	c.(178-180)TTT>GTT	p.F60V	CDH17_uc011lgo.1_Missense_Mutation_p.F60V|CDH17_uc011lgp.1_Missense_Mutation_p.F60V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	60	Extracellular (Potential).|Cadherin 1.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTTAGTTCAAAAGTCACAGCA	0.403			NA											22	43					0	0	0.010504	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361457	105361457	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:105361457G>T	uc003ylx.1	+	2	726	c.677G>T	c.(676-678)GGC>GTC	p.G226V		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	226	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GTCCTGCTTGGCACTGGCCTC	0.498			NA											20	78					1.37522e-17	2.3695e-17	0.007413	1	0
CSMD3	114788	broad.mit.edu	37	8	113253949	113253949	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:113253949C>A	uc003ynu.2	-	66	10627	c.10468G>T	c.(10468-10470)GTT>TTT	p.V3490F	CSMD3_uc003yns.2_Missense_Mutation_p.V2692F|CSMD3_uc003ynt.2_Missense_Mutation_p.V3450F|CSMD3_uc011lhx.1_Missense_Mutation_p.V3321F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3490	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTACTAACCACTTAGCTTT	0.308			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	87					2.59497e-14	4.20331e-14	0.007835	1	0
ZHX1	11244	broad.mit.edu	37	8	124266145	124266145	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:124266145C>A	uc003yqe.2	-	3	2472	c.2042G>T	c.(2041-2043)CGG>CTG	p.R681L	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.R681L|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.R681L	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	681	Homeobox 4.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			CCACTGTGTCCGGACAAATGC	0.478			NA											29	52					5.77227e-19	1.0171e-18	0.008361	1	0
CYP11B2	1585	broad.mit.edu	37	8	143994821	143994821	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:143994821G>T	uc003yxk.1	-	6	1004	c.1001C>A	c.(1000-1002)CCC>CAC	p.P334H		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	334					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CTGCACGTCGGGGTTCCGAGC	0.637			NA							Familial_Hyperaldosteronism_type_I				33	86					1.36161e-19	2.43369e-19	0.004289	1	0
OPLAH	26873	broad.mit.edu	37	8	145108265	145108265	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:145108265C>A	uc003zar.3	-	20	2800	c.2718G>T	c.(2716-2718)AAG>AAT	p.K906N	OPLAH_uc003zas.1_Missense_Mutation_p.G181C	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	906							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	AGTTGGGGACCTTGCCTGGCG	0.657			NA											14	64					6.31663e-08	8.43121e-08	0.003163	1	0
FREM1	158326	broad.mit.edu	37	9	14737474	14737474	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:14737474C>A	uc003zlm.2	-	37	7050	c.6460G>T	c.(6460-6462)GTT>TTT	p.V2154F	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.V690F	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2154	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TGTCTTTGAACCAAAACACAG	0.478			NA											7	24					2.0095e-06	2.49483e-06	0.001984	1	0
FRMPD1	22844	broad.mit.edu	37	9	37707468	37707468	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:37707468C>A	uc004aag.1	+	3	201	c.157C>A	c.(157-159)CCT>ACT	p.P53T	FRMPD1_uc004aah.1_Missense_Mutation_p.P53T	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	53						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GACCCTCATCCCTGTGCGACA	0.502			NA											41	86					8.69298e-16	1.4535e-15	0.006999	1	0
FAM75A6	389730	broad.mit.edu	37	9	43627644	43627645	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:43627644_43627645CC>AA	uc011lrb.1	-	4	1071_1072	c.1042_1043GG>TT	c.(1042-1044)GGA>TTA	p.G348L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	348						integral to membrane					0						TGTAAATGATCCAACATTTTCT	0.426			NA											104	72					0	0	0.004672	0	0
FAM75A6	389730	broad.mit.edu	37	9	43630516	43630516	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:43630516T>C	uc011lrb.1	-	1	215	c.186A>G	c.(184-186)AGA>AGG	p.R62R		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	62						integral to membrane					0						TCCTTACCTTTCTCTTCCCAG	0.468			NA											61	40					0	0	0.00361	0	0
LOC442421	442421	broad.mit.edu	37	9	66499722	66499722	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:66499722C>T	uc004aee.1	+	1	532	c.532C>T	c.(532-534)CTG>TTG	p.L178L	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						GCCCAATCTGCTGGACAGCCT	0.597			NA											8	102					0	0	0.008291	0	0
Unknown	0	broad.mit.edu	37	9	69067929	69067929	+	Splice_Site	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:69067929G>A	uc004afe.1	+	3		c.744_splice	c.e3+1		uc010mnq.1_Splice_Site					Homo sapiens cDNA, FLJ18209.												NA						TGATATGTTGGTGAGTCAGTT	0.209			NA											10	20					0	0	0.003163	0	0
FOXB2	442425	broad.mit.edu	37	9	79635314	79635314	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:79635314G>T	uc004ako.1	+	1	744	c.744G>T	c.(742-744)GGG>GGT	p.G248G		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	248					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CACCCTACGGGCTGGGCTCGg	0.378			NA											15	16					7.93312e-07	1.00908e-06	0.00245	1	0
NTRK2	4915	broad.mit.edu	37	9	87570366	87570366	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:87570366G>C	uc004aoa.1	+	18	2996	c.2058G>C	c.(2056-2058)GAG>GAC	p.E686D	NTRK2_uc004any.1_Missense_Mutation_p.E686D|NTRK2_uc004anz.1_Missense_Mutation_p.E702D	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	686	Protein kinase.|Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TGGTCGGGGAGAACTTGCTGG	0.597			NA								TSP Lung(25;0.17)			6	34					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	9	90744655	90744655	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:90744655C>A	uc011lti.1	-	4	3326	c.3297G>T	c.(3295-3297)CCG>CCT	p.P1099P	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;												NA						CTGAGTAGAACGGGTGTCTGT	0.517			NA											97	120					4.01927e-73	7.73989e-73	0.00361	1	0
COL15A1	1306	broad.mit.edu	37	9	101749627	101749627	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:101749627C>A	uc004azb.1	+	4	906	c.700C>A	c.(700-702)CTG>ATG	p.L234M		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	234	Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TCCCGAGGAGCTGTGTGACCC	0.642			NA											15	160					1.3612e-06	1.72438e-06	0.003163	1	0
PTGR1	22949	broad.mit.edu	37	9	114348369	114348369	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:114348369T>C	uc004bfh.2	-	5	389	c.286A>G	c.(286-288)ATT>GTT	p.I96V	PTGR1_uc011lwr.1_Missense_Mutation_p.I96V|PTGR1_uc004bfi.3_Missense_Mutation_p.I96V|PTGR1_uc004bfj.3_5'UTR|PTGR1_uc010mue.2_Missense_Mutation_p.I96V	NM_012212	NP_036344	Q14914	PTGR1_HUMAN	prostaglandin reductase 1 isoform 1	96					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding				0						CCATCAGAAATGGAGTGCGTT	0.473	Ovarian(200;132 2151 7551 19220 46064)		NA											28	53					0	0	0.005443	0	0
PAPPA	5069	broad.mit.edu	37	9	119106938	119106938	+	Missense_Mutation	SNP	G	G	T	rs142176678		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:119106938G>T	uc004bjn.2	+	14	4109	c.3728G>T	c.(3727-3729)CGG>CTG	p.R1243L	PAPPA_uc011lxq.1_Missense_Mutation_p.R618L	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1243	Sushi 1.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGAGCTGCCGGACAGGCTAC	0.582			NA											33	45					2.80507e-11	4.19412e-11	0.012213	1	0
TLR4	7099	broad.mit.edu	37	9	120476646	120476646	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:120476646G>T	uc004bjz.2	+	3	2531	c.2240G>T	c.(2239-2241)TGT>TTT	p.C747F	TLR4_uc004bka.2_Missense_Mutation_p.C707F|TLR4_uc004bkb.2_Missense_Mutation_p.C547F	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	747	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AGCCGCTGGTGTATCTTTGAA	0.507			NA											4	68					0.00024832	0.000280318	0.009096	1	0
AK1	203	broad.mit.edu	37	9	130635071	130635071	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:130635071G>A	uc004bsm.3	-	4	258	c.105C>T	c.(103-105)ACC>ACT	p.T35T		NM_000476	NP_000467	P00568	KAD1_HUMAN	adenylate kinase 1	35					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding				0						TGGAGAGGTGGGTGTAGCCAT	0.617			NA											5	41					0	0	0.000602	0	0
ADAMTSL2	9719	broad.mit.edu	37	9	136405847	136405847	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:136405847C>A	uc011mdl.1	+	6	1097	c.540C>A	c.(538-540)TGC>TGA	p.C180*	ADAMTSL2_uc004cei.2_Nonsense_Mutation_p.C180*	NM_001145320	NP_001138792	Q86TH1	ATL2_HUMAN	ADAMTS-like 2 precursor	180					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		GAGGGGTTTGCGTGTCTGGAA	0.637			NA											16	26					3.52763e-06	4.33634e-06	0.00499	1	0
COL5A1	1289	broad.mit.edu	37	9	137630345	137630345	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:137630345G>T	uc004cfe.2	+	10	1797	c.1415G>T	c.(1414-1416)GGC>GTC	p.G472V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	472	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGCCCGCCTGGCCCAGAAGGC	0.642			NA											7	76					1.58986e-06	1.99374e-06	0.008291	1	0
SOHLH1	402381	broad.mit.edu	37	9	138588531	138588531	+	Silent	SNP	C	C	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:138588531C>G	uc004cgl.2	-	5	649	c.588G>C	c.(586-588)ACG>ACC	p.T196T	SOHLH1_uc010nbe.2_Silent_p.T196T	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	196					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		TGCCCAGGGACGTGCAGCTCG	0.667			NA											17	26					0	0	0.00499	0	0
MAMDC4	158056	broad.mit.edu	37	9	139747556	139747556	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:139747556G>T	uc004cjs.2	+	2	99	c.49G>T	c.(49-51)GGG>TGG	p.G17W	MAMDC4_uc011mej.1_Translation_Start_Site	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	17					protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCCAGCAGCAGGGTCCTCAGG	0.463			NA											18	12					1.67942e-08	2.30087e-08	0.006122	1	0
TUBBP5	643224	broad.mit.edu	37	9	141071111	141071111	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr9:141071111G>T	uc004com.2	+	4	775	c.514G>T	c.(514-516)GGC>TGC	p.G172C	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GCGCTTCCCAGGCCAGCTGAA	0.602			NA											4	75					1.23904e-05	1.49647e-05	0.000602	1	0
TLR7	51284	broad.mit.edu	37	X	12906090	12906090	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:12906090G>A	uc004cvc.2	+	3	2602	c.2463G>A	c.(2461-2463)AAG>AAA	p.K821K		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	821	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	GAGCACACAAGGGCCAAAGTG	0.488			NA											13	74					0	0	0.001855	0	0
ATXN3L	92552	broad.mit.edu	37	X	13337276	13337276	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:13337276C>A	uc010ned.2	-	1	1243	c.778G>T	c.(778-780)GGA>TGA	p.G260*		NM_001135995	NP_001129467	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	260					protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			lung(2)|ovary(2)|large_intestine(1)|skin(1)	6						GATGTGTTTCCGGAACTACCT	0.428			NA											10	330					1.58986e-06	1.99374e-06	0.008291	1	0
RAI2	10742	broad.mit.edu	37	X	17818712	17818712	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:17818712G>T	uc004cyf.2	-	3	1989	c.1419C>A	c.(1417-1419)TCC>TCA	p.S473S	RAI2_uc004cyg.2_Silent_p.S473S|RAI2_uc010nfa.2_Silent_p.S473S|RAI2_uc004cyh.3_Silent_p.S473S|RAI2_uc011miy.1_Silent_p.S423S	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	473					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					CCTGAAGCACGGAGTCTTCTC	0.478			NA											38	276					1.69901e-12	2.64858e-12	0.005524	1	0
BEND2	139105	broad.mit.edu	37	X	18230737	18230737	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:18230737T>C	uc004cyj.3	-	4	594	c.440A>G	c.(439-441)TAC>TGC	p.Y147C	BEND2_uc010nfb.2_Missense_Mutation_p.Y147C	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	147										ovary(3)|kidney(1)|central_nervous_system(1)	5						CTCTGAGTTGTAACTGTATCT	0.338			NA											10	71					0	0	0.001855	0	0
CNKSR2	22866	broad.mit.edu	37	X	21444616	21444616	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:21444616T>C	uc004czx.1	+	2	102	c.66T>C	c.(64-66)GGT>GGC	p.G22G	CNKSR2_uc004czw.2_Silent_p.G22G|CNKSR2_uc011mjn.1_Silent_p.G22G|CNKSR2_uc011mjo.1_Silent_p.G22G	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	22	SAM.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						ATTTTGTAGGTCTTGATGACT	0.413			NA											4	40					0	0	0.009096	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212219	26212219	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:26212219G>T	uc004dbr.2	+	2	405	c.256G>T	c.(256-258)GCC>TCC	p.A86S	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	86	Ser-rich.									ovary(3)	3						CGATGTGGCTGCCAACGGCCA	0.542			NA											10	52					1.33987e-11	2.03268e-11	0.008291	1	0
MAGEB4	4115	broad.mit.edu	37	X	30261111	30261111	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:30261111G>T	uc004dcb.2	+	1	943	c.859G>T	c.(859-861)GAG>TAG	p.E287*	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	287	MAGE.									ovary(1)	1						GAAAGTCCTGGAGTTTTTGGC	0.512			NA											26	59					6.32553e-13	9.93556e-13	0.004656	1	0
FAM47C	442444	broad.mit.edu	37	X	37027649	37027649	+	Missense_Mutation	SNP	C	C	T	rs148424680	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:37027649C>T	uc004ddl.1	+	1	1180	c.1166C>T	c.(1165-1167)CCT>CTT	p.P389L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	389										ovary(3)	3						CGCGTACCTCCTCTCCGCCCA	0.617			NA											35	85					0	0	0.003755	0	0
MAOB	4129	broad.mit.edu	37	X	43662545	43662545	+	Splice_Site	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:43662545A>T	uc004dfz.3	-	4	560	c.384_splice	c.e4+1	p.E128_splice	MAOB_uc011mkx.1_Splice_Site_p.E112_splice|MAOB_uc011mky.1_Splice_Site_p.E112_splice	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B						xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	AAGAAGCTTTACCTCTCGCCC	0.318			NA											4	45					0	0	0.009096	0	0
PHF16	9767	broad.mit.edu	37	X	46917891	46917891	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:46917891G>T	uc004dgx.2	+	11	1935	c.1884G>T	c.(1882-1884)TCG>TCT	p.S628S	PHF16_uc004dgy.2_Silent_p.S628S	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	628					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						CCCCGTCCTCGGAGTGCTATC	0.537			NA											9	62					1.76689e-08	2.4101e-08	0.006214	1	0
NDUFB11	54539	broad.mit.edu	37	X	47002067	47002067	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:47002067A>T	uc004dhd.2	-	2	815	c.284T>A	c.(283-285)GTC>GAC	p.V95D	NDUFB11_uc004dhc.2_Missense_Mutation_p.V95D|RBM10_uc004dhe.1_5'Flank|RBM10_uc004dhf.2_5'Flank|RBM10_uc004dhg.2_5'Flank|RBM10_uc004dhh.2_5'Flank|RBM10_uc010nhq.2_5'Flank|RBM10_uc004dhi.2_5'Flank	NM_001135998	NP_001129470	Q9NX14	NDUBB_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	95	Helical; (Potential).				respiratory electron transport chain|transport	integral to membrane|mitochondrial respiratory chain complex I					0						GATGATGGAGACGCCAAAGAA	0.532	Ovarian(77;454 1296 7908 21551 37072)		NA											23	67					0	0	0.00333	0	0
SLC35A2	7355	broad.mit.edu	37	X	48767203	48767203	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:48767203G>A	uc004dlo.1	-	2	166	c.162C>T	c.(160-162)ATC>ATT	p.I54I	SLC35A2_uc011mml.1_Silent_p.I67I|SLC35A2_uc004dlp.1_Silent_p.I54I|SLC35A2_uc011mmm.1_Silent_p.I82I|SLC35A2_uc011mmn.1_Intron|SLC35A2_uc004dlr.1_5'UTR|SLC35A2_uc004dlq.2_Silent_p.I54I|SLC35A2_uc011mmo.1_Silent_p.I67I	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	54	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						GGGCGTAGCGGATGCTGAGGA	0.612			NA											7	32					0	0	0.001984	0	0
MAGIX	79917	broad.mit.edu	37	X	49022560	49022560	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:49022560C>A	uc010nin.1	+	6	874	c.827C>A	c.(826-828)GCC>GAC	p.A276D	MAGIX_uc010nio.1_Missense_Mutation_p.A200D|MAGIX_uc004dmt.2_Missense_Mutation_p.A195D|MAGIX_uc004dmu.2_Missense_Mutation_p.A217D|MAGIX_uc004dmw.2_Missense_Mutation_p.A204D	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	276											0						CCAGAGGCGGCCGCCGATGGC	0.687			NA											7	12					0.000157383	0.000179949	0.00308	1	0
FAM123B	139285	broad.mit.edu	37	X	63411318	63411318	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:63411318C>A	uc004dvo.2	-	2	2122	c.1849G>T	c.(1849-1851)GAA>TAA	p.E617*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	617					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCATGAGCTTCCCAAGTGTGG	0.637			NA											5	39					0.000602214	0.000670085	0.000602	1	0
CXCR3	2833	broad.mit.edu	37	X	70837092	70837092	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:70837092A>T	uc004eaf.2	-	2	298	c.230T>A	c.(229-231)GTG>GAG	p.V77E	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Missense_Mutation_p.V124E	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	77	Helical; Name=1; (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					GCTCAGCAGCACGGCTGCCAC	0.662			NA											3	8					0	0	0.004672	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649518	75649518	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:75649518G>C	uc004ecm.1	+	1	1402	c.1195G>C	c.(1195-1197)GGA>CGA	p.G399R		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	399	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CGCCCCTGACGGACCGGGAAG	0.642			NA											8	20					0	0	0.00308	0	0
FGF16	8823	broad.mit.edu	37	X	76711990	76711990	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:76711990A>G	uc011mqp.1	+	2	601	c.328A>G	c.(328-330)AGA>GGA	p.R110G		NM_003868	NP_003859	O43320	FGF16_HUMAN	fibroblast growth factor 16	201					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|metabolic process|organ morphogenesis|response to temperature stimulus	extracellular space	growth factor activity			lung(1)	1						CTCCATGTCCAGAGACCTCTT	0.502			NA											10	79					0	0	0.008291	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873704	91873704	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:91873704G>C	uc004efk.1	+	7	4654	c.3809G>C	c.(3808-3810)AGT>ACT	p.S1270T	PCDH11X_uc004efl.1_Missense_Mutation_p.S1260T|PCDH11X_uc004efo.1_Missense_Mutation_p.S1233T|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.S1262T|PCDH11X_uc004efn.1_Missense_Mutation_p.S1252T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1270	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTCCATCGTAGTCAGGCCCAA	0.552	NSCLC(38;925 1092 2571 38200 45895)		NA											34	182					0	0	0.003755	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529087	102529087	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:102529087T>C	uc004ejz.1	-	3	700	c.405A>G	c.(403-405)TTA>TTG	p.L135L		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						GCCTTTCTTGTAAGTCCTCCT	0.512			NA											4	230					0	0	0.009096	0	0
NRK	203447	broad.mit.edu	37	X	105152724	105152724	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:105152724C>A	uc004emd.2	+	13	1394	c.1091C>A	c.(1090-1092)CCC>CAC	p.P364H	NRK_uc010npc.1_Missense_Mutation_p.P32H	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	364							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TTTAGAGGACCCTCTTGCACT	0.443			NA								HNSCC(51;0.14)			9	52					2.17888e-05	2.58145e-05	0.006214	1	0
CXorf57	55086	broad.mit.edu	37	X	105882817	105882817	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:105882817G>T	uc004emi.3	+	9	1785	c.1634G>T	c.(1633-1635)AGG>ATG	p.R545M	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	545										ovary(1)|lung(1)|breast(1)	3						TTGCAGTATAGGGAACAAAAG	0.408			NA											15	118					2.23348e-06	2.76738e-06	0.004007	1	0
TEX13B	56156	broad.mit.edu	37	X	107225222	107225222	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:107225222C>A	uc004enn.1	-	2	229	c.136G>T	c.(136-138)GTG>TTG	p.V46L		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	46										ovary(1)	1						TTGTCTTCCACCTCCTCCCAG	0.597			NA											15	176					6.31663e-08	8.43121e-08	0.003163	1	0
IRS4	8471	broad.mit.edu	37	X	107977374	107977374	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:107977374C>A	uc004eoc.2	-	1	2234	c.2201G>T	c.(2200-2202)CGA>CTA	p.R734L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	734	CRK-binding.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						AAAAGGGGATCGAGAGTGGCG	0.498			NA											20	170					5.35267e-07	6.87884e-07	0.007413	1	0
LHFPL1	340596	broad.mit.edu	37	X	111914478	111914478	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:111914478G>A	uc004epq.2	-	2	474	c.141C>T	c.(139-141)TTC>TTT	p.F47F	LHFPL1_uc004epp.2_Silent_p.F70F|LHFPL1_uc010nqa.2_Intron|LHFPL1_uc010nqb.2_Silent_p.F47F	NM_178175	NP_835469	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1 precursor	47						integral to membrane					0						TGCACCTCCGGAATGTGCTGA	0.542			NA											14	233					0	0	0.00245	0	0
KIAA1210	57481	broad.mit.edu	37	X	118221651	118221651	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:118221651C>A	uc004era.3	-	11	3542	c.3542G>T	c.(3541-3543)GGC>GTC	p.G1181V		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1181										ovary(4)|skin(1)	5						GTTAGAAGTGCCTTCAACAGC	0.463			NA											7	53					1.26484e-09	1.81694e-09	0.00308	1	0
UBE2A	7319	broad.mit.edu	37	X	118709339	118709339	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:118709339C>A	uc004erl.2	+	3	303	c.127C>A	c.(127-129)CCT>ACT	p.P43T	UBE2A_uc004erm.2_Missense_Mutation_p.P43T|UBE2A_uc004ern.2_RNA|UBE2A_uc004ero.2_RNA	NM_003336	NP_003327	P49459	UBE2A_HUMAN	ubiquitin-conjugating enzyme E2A isoform 1	43					histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						GTGTTGCAGGCCTGAAGGGAC	0.542			NA						Direct_reversal_of_damage|Rad6_pathway					24	119					7.92952e-12	1.20886e-11	0.003954	1	0
RNF113A	7737	broad.mit.edu	37	X	119005497	119005497	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:119005497G>T	uc004esb.2	-	1	295	c.80C>A	c.(79-81)GCT>GAT	p.A27D	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	27							nucleic acid binding|zinc ion binding			breast(2)	2						GCGTCCAGCAGCCCCTTTCCG	0.597			NA											28	130					4.59853e-10	6.66733e-10	0.005443	1	0
SH2D1A	4068	broad.mit.edu	37	X	123480538	123480538	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:123480538G>T	uc004euf.3	+	1	391	c.46G>T	c.(46-48)GGC>TGC	p.G16C	SH2D1A_uc004euh.3_Missense_Mutation_p.G16C|SH2D1A_uc004eug.3_RNA|SH2D1A_uc010nqw.2_RNA|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	16	SH2.		G -> D (in XLP1; abolishes interaction with SLAMF1).		cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						CAGGGAAACCGGCGAGAAGCT	0.592			NA							X-linked_Lymphoproliferative_syndrome				22	61					1.87028e-06	2.33597e-06	0.012319	1	0
XPNPEP2	7512	broad.mit.edu	37	X	128873207	128873207	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:128873207G>T	uc004eut.1	+	1	262	c.18G>T	c.(16-18)TGG>TGT	p.W6C	XPNPEP2_uc011mum.1_Missense_Mutation_p.W6C	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	6					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						GGGCTCACTGGGGCTGCTGCC	0.637			NA											8	251					2.17888e-05	2.58145e-05	0.006214	1	0
BCORL1	63035	broad.mit.edu	37	X	129149581	129149581	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:129149581C>T	uc004evb.1	+	4	2947	c.2833C>T	c.(2833-2835)CGA>TGA	p.R945*	BCORL1_uc010nrd.1_Nonsense_Mutation_p.R847*	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	945					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGGGGACATTCGAATGAATCA	0.577			NA											16	130					0	0	0.004007	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218253	130218253	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:130218253A>T	uc004evz.2	+	5	965	c.620A>T	c.(619-621)CAG>CTG	p.Q207L	ARHGAP36_uc004ewa.2_Missense_Mutation_p.Q195L|ARHGAP36_uc004ewb.2_Missense_Mutation_p.Q176L|ARHGAP36_uc004ewc.2_Missense_Mutation_p.Q71L	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	207					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CAGACCCTGCAGCTTTCAAAA	0.478			NA											54	35					0	0	0.00361	0	0
MBNL3	55796	broad.mit.edu	37	X	131540343	131540343	+	Silent	SNP	C	C	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:131540343C>T	uc004ewv.3	-	2	334	c.255G>A	c.(253-255)CGG>CGA	p.R85R	uc004ewr.1_Intron|MBNL3_uc004eww.2_5'UTR|MBNL3_uc010nrl.1_RNA|MBNL3_uc004ews.2_5'UTR|MBNL3_uc004ewt.2_Silent_p.R35R|MBNL3_uc011muz.1_5'UTR|MBNL3_uc004ewu.3_Silent_p.R85R|MBNL3_uc004ewx.1_Silent_p.R35R	NM_018388	NP_060858	Q9NUK0	MBNL3_HUMAN	muscleblind-like 3 isoform G	85					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					TCAGATTGTTCCGCCCATTAA	0.488			NA											15	114					0	0	0.00245	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291176	141291176	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:141291176C>A	uc004fbu.1	-	3	946	c.598G>T	c.(598-600)GTG>TTG	p.V200L		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	200	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGGGCCCACTTCTATCAGG	0.478			NA								HNSCC(46;0.14)			184	121					3.73429e-81	7.25853e-81	0.00361	1	0
SLITRK2	84631	broad.mit.edu	37	X	144906475	144906475	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:144906475G>A	uc004fcd.2	+	5	3522	c.2532G>A	c.(2530-2532)CAG>CAA	p.Q844Q	SLITRK2_uc010nsp.2_Silent_p.Q844Q|SLITRK2_uc010nso.2_Silent_p.Q844Q|SLITRK2_uc011mwq.1_Silent_p.Q844Q|SLITRK2_uc011mwr.1_Silent_p.Q844Q|SLITRK2_uc011mws.1_Silent_p.Q844Q|SLITRK2_uc004fcg.2_Silent_p.Q844Q|SLITRK2_uc011mwt.1_Silent_p.Q844Q|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	844	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CAATCAGTCAGCTGTGAAGGG	0.458			NA											72	51					0	0	0.00361	0	0
AFF2	2334	broad.mit.edu	37	X	148039929	148039929	+	Silent	SNP	C	C	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:148039929C>A	uc004fcp.2	+	12	3110	c.2631C>A	c.(2629-2631)ATC>ATA	p.I877I	AFF2_uc004fcq.2_Silent_p.I867I|AFF2_uc004fcr.2_Silent_p.I838I|AFF2_uc011mxb.1_Silent_p.I842I|AFF2_uc004fcs.2_Silent_p.I844I|AFF2_uc011mxc.1_Silent_p.I518I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	877					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCACAACTATCTGCTTGCTCC	0.512			NA											160	190					5.70634e-75	1.10228e-74	0.00361	1	0
MAMLD1	10046	broad.mit.edu	37	X	149638377	149638377	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:149638377G>C	uc004fee.1	+	3	608	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	MAMLD1_uc011mxt.1_Missense_Mutation_p.E140Q|MAMLD1_uc011mxu.1_Missense_Mutation_p.E153Q|MAMLD1_uc011mxv.1_Missense_Mutation_p.E153Q|MAMLD1_uc011mxw.1_Missense_Mutation_p.E105Q	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	178					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGCTTCAAGAGCTGCTAGA	0.478			NA											17	170					0	0	0.00499	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639648	149639648	+	Silent	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:149639648G>A	uc004fee.1	+	3	1879	c.1803G>A	c.(1801-1803)CAG>CAA	p.Q601Q	MAMLD1_uc011mxt.1_Silent_p.Q563Q|MAMLD1_uc011mxu.1_Silent_p.Q576Q|MAMLD1_uc011mxv.1_Silent_p.Q576Q|MAMLD1_uc011mxw.1_Silent_p.Q528Q	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	601	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					agcagcagcagcaacagcagc	0.483			NA											5	216					0	0	0.001168	0	0
HCFC1	3054	broad.mit.edu	37	X	153215033	153215033	+	Silent	SNP	G	G	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:153215033G>T	uc004fjp.2	-	25	6567	c.6039C>A	c.(6037-6039)GCC>GCA	p.A2013A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	2013					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCGCTTGTTGGCTGGCTTGG	0.547			NA											12	170					0.000219431	0.000249975	0.00245	1	0
TMEM187	8269	broad.mit.edu	37	X	153247646	153247646	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:153247646G>A	uc004fjq.2	+	2	667	c.133G>A	c.(133-135)GTG>ATG	p.V45M	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	45	Helical; (Potential).					integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGAGGCGCCCGTGGCCGGCCT	0.662			NA											17	180					0	0	0.007413	0	0
SLC10A3	8273	broad.mit.edu	37	X	153716440	153716440	+	Missense_Mutation	SNP	G	G	T	rs151043660		TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:153716440G>T	uc004flq.2	-	3	1104	c.840C>A	c.(838-840)GAC>GAA	p.D280E	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Missense_Mutation_p.D251E|SLC10A3_uc004flp.2_Missense_Mutation_p.D280E	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	280					organic anion transport	integral to membrane	bile acid:sodium symporter activity	p.D280N(1)		ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAGGGTGACGTCCCCTCCAA	0.622			NA											13	103					7.03913e-09	9.75131e-09	0.001368	1	0
F8	2157	broad.mit.edu	37	X	154158987	154158987	+	Silent	SNP	T	T	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:154158987T>C	uc004fmt.2	-	14	3249	c.3078A>G	c.(3076-3078)TCA>TCG	p.S1026S		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1026	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TATTAGTTGCTGAATTATTGG	0.333			NA											60	57					0	0	0.00361	0	0
NFASC	23114	broad.mit.edu	37	1	204978720	204978721	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr1:204978720_204978721insA	uc001hbj.2	+	28	3653_3654	c.3325_3326insA	c.(3325-3327)GGCfs	p.G1109fs	NFASC_uc010pra.1_Frame_Shift_Ins_p.G1043fs|NFASC_uc001hbi.2_Frame_Shift_Ins_p.G1038fs|NFASC_uc010prb.1_Frame_Shift_Ins_p.G1058fs|NFASC_uc010prc.1_Frame_Shift_Ins_p.G609fs|NFASC_uc001hbl.1_Frame_Shift_Ins_p.G185fs|NFASC_uc001hbm.1_Frame_Shift_Ins_p.G132fs|NFASC_uc009xbh.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1216	Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CGCCACCCAGGGCTGGTTCATT	0.589			NA											17	115	---	---	---	---	NA	NA	NA	NA	NA
OR51M1	390059	broad.mit.edu	37	11	5410741	5410741	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr11:5410741delG	uc010qzc.1	+	1	113	c.113delG	c.(112-114)TGGfs	p.W38fs	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	38						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCAAACACTGGATTTTCATC	0.423			NA											12	175	---	---	---	---	NA	NA	NA	NA	NA
NDRG2	57447	broad.mit.edu	37	14	21486164	21486164	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr14:21486164delG	uc001vyy.2	-	16	1081	c.931delC	c.(931-933)CTGfs	p.L311fs	NDRG2_uc010tll.1_Frame_Shift_Del_p.L307fs|NDRG2_uc001vyt.2_Frame_Shift_Del_p.L224fs|NDRG2_uc001vyu.2_Frame_Shift_Del_p.L268fs|NDRG2_uc001vyv.2_Frame_Shift_Del_p.L297fs|NDRG2_uc001vyw.2_Frame_Shift_Del_p.L297fs|NDRG2_uc001vzb.2_Frame_Shift_Del_p.L251fs|NDRG2_uc001vyx.2_Frame_Shift_Del_p.L311fs|NDRG2_uc001vza.2_Frame_Shift_Del_p.L297fs|NDRG2_uc001vyz.2_Frame_Shift_Del_p.L297fs|NDRG2_uc001vzc.2_Frame_Shift_Del_p.L281fs|NDRG2_uc001vze.2_Frame_Shift_Del_p.L311fs|NDRG2_uc001vzd.2_Frame_Shift_Del_p.L311fs|NDRG2_uc001vzg.2_Frame_Shift_Del_p.L297fs|NDRG2_uc001vzf.2_Frame_Shift_Del_p.L297fs|NDRG2_uc010aig.2_Frame_Shift_Del_p.L300fs	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	311					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ATGCCTTGCAGGAAGTACTTG	0.562			NA											26	202	---	---	---	---	NA	NA	NA	NA	NA
LRP3	4037	broad.mit.edu	37	19	33698115	33698116	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:33698115_33698116insA	uc010edh.2	+	7	2040_2041	c.1947_1948insA	c.(1945-1950)GACCCCfs	p.D649fs	LRP3_uc002nuk.3_Frame_Shift_Ins_p.D523fs	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	649_650	Cytoplasmic (Potential).				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					CTGCCCCCGACCCCCCAGCACC	0.743			NA											5	6	---	---	---	---	NA	NA	NA	NA	NA
HKR1	284459	broad.mit.edu	37	19	37854204	37854204	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:37854204delG	uc002ogb.2	+	6	1776	c.1507delG	c.(1507-1509)GGGfs	p.G503fs	HKR1_uc002ofx.2_Frame_Shift_Del_p.G219fs|HKR1_uc002ofy.2_Frame_Shift_Del_p.G219fs|HKR1_uc002oga.2_Frame_Shift_Del_p.G485fs|HKR1_uc010xto.1_Frame_Shift_Del_p.G485fs|HKR1_uc002ogc.2_Frame_Shift_Del_p.G484fs|HKR1_uc010xtp.1_Frame_Shift_Del_p.G442fs|HKR1_uc002ogd.2_Frame_Shift_Del_p.G442fs	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	503	C2H2-type 8.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TACGGAGTGTGGGCGAGGCTT	0.532			NA											14	78	---	---	---	---	NA	NA	NA	NA	NA
HNRNPUL1	11100	broad.mit.edu	37	19	41798236	41798237	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr19:41798236_41798237insT	uc002oqb.3	+	8	1375_1376	c.1086_1087insT	c.(1084-1089)GCCTTGfs	p.A362fs	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Frame_Shift_Ins_p.A262fs|HNRNPUL1_uc002oqa.3_Frame_Shift_Ins_p.A262fs|HNRNPUL1_uc010ehm.2_Frame_Shift_Ins_p.A362fs|HNRNPUL1_uc002oqc.3_Frame_Shift_Ins_p.A248fs|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Frame_Shift_Ins_p.A262fs|HNRNPUL1_uc010ehn.2_Frame_Shift_Ins_p.A262fs|HNRNPUL1_uc010eho.2_Frame_Shift_Ins_p.A262fs|HNRNPUL1_uc010xvy.1_Frame_Shift_Ins_p.A262fs|HNRNPUL1_uc010ehp.2_Frame_Shift_Ins_p.A218fs|HNRNPUL1_uc010ehl.1_Frame_Shift_Ins_p.A262fs	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	362_363	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						AGAAGGAAGCCTTGGGGGGTCA	0.505			NA											23	142	---	---	---	---	NA	NA	NA	NA	NA
CTNNA2	1496	broad.mit.edu	37	2	79878782	79878783	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:79878782_79878783insA	uc010ysh.1	+	1	105_106	c.100_101insA	c.(100-102)CAGfs	p.Q34fs	CTNNA2_uc010yse.1_Frame_Shift_Ins_p.Q34fs|CTNNA2_uc010ysf.1_Frame_Shift_Ins_p.Q34fs|CTNNA2_uc010ysg.1_Frame_Shift_Ins_p.Q34fs|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	34					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						ACTTGTTACACAGGTAAGGGAT	0.391			NA											18	53	---	---	---	---	NA	NA	NA	NA	NA
COL5A2	1290	broad.mit.edu	37	2	189904256	189904257	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr2:189904256_189904257insA	uc002uqk.2	-	51	3941_3942	c.3666_3667insT	c.(3664-3669)CCTCCGfs	p.P1222fs	COL5A2_uc010frx.2_Frame_Shift_Ins_p.P798fs	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1222_1223					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGGGGACCCGGAGGGCCAGGTG	0.49			NA											8	48	---	---	---	---	NA	NA	NA	NA	NA
NCOA6	23054	broad.mit.edu	37	20	33330968	33330970	+	In_Frame_Del	DEL	TGC	TGC	-	rs112895426	byFrequency	TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	TGC	TGC	-	-	TGC	TGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:33330968_33330970delTGC	uc002xav.2	-	12	5661_5663	c.3090_3092delGCA	c.(3088-3093)CAGCAA>CAA	p.1030_1031QQ>Q	NCOA6_uc002xaw.2_In_Frame_Del_p.1030_1031QQ>Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1030_1031	NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CATCATTtgttgctgctgctgct	0.498			NA											7	138	---	---	---	---	NA	NA	NA	NA	NA
CTCFL	140690	broad.mit.edu	37	20	56094353	56094353	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr20:56094353delG	uc010gix.1	-	3	1497	c.835delC	c.(835-837)CACfs	p.H279fs	CTCFL_uc010giw.1_Frame_Shift_Del_p.H279fs|CTCFL_uc002xym.2_Frame_Shift_Del_p.H279fs|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gjb.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gjc.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gjd.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gje.2_Frame_Shift_Del_p.H279fs|CTCFL_uc010gjf.2_Frame_Shift_Del_p.H74fs|CTCFL_uc010gjg.2_Frame_Shift_Del_p.H11fs|CTCFL_uc010gjh.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gji.1_Frame_Shift_Del_p.H74fs|CTCFL_uc010gjj.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gjk.1_Frame_Shift_Del_p.H279fs|CTCFL_uc010gjl.1_Frame_Shift_Del_p.H279fs	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	279	C2H2-type 1.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TCACTGGTGTGAGTTTTCATA	0.458			NA											16	68	---	---	---	---	NA	NA	NA	NA	NA
RNF160	26046	broad.mit.edu	37	21	30313665	30313666	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr21:30313665_30313666insA	uc002ymr.2	-	25	4509_4510	c.4496_4497insT	c.(4495-4497)TTGfs	p.L1499fs		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1453							ligase activity|zinc ion binding				0						GAATACACCCCAAAACATTTTC	0.366			NA											64	47	---	---	---	---	NA	NA	NA	NA	NA
GAB4	128954	broad.mit.edu	37	22	17472833	17472833	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr22:17472833delG	uc002zlw.2	-	2	516	c.408delC	c.(406-408)ACCfs	p.T136fs	GAB4_uc010gqs.1_Frame_Shift_Del_p.T136fs	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	136	PH.									large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGTCCTCCCTGGTCTCAGCCA	0.502			NA											54	215	---	---	---	---	NA	NA	NA	NA	NA
COL25A1	84570	broad.mit.edu	37	4	109861693	109861694	+	Splice_Site	INS	-	-	C			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:109861693_109861694insC	uc003hze.1	-	9	1203	c.672_splice	c.e9+1	p.P224_splice	COL25A1_uc003hzg.2_Splice_Site_p.P224_splice|COL25A1_uc003hzd.2_Intron|COL25A1_uc003hzf.2_Splice_Site_p.P5_splice	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1							collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		AAAGCGACTCACGGGTACTCCT	0.47			NA											25	112	---	---	---	---	NA	NA	NA	NA	NA
DCHS2	54798	broad.mit.edu	37	4	155241794	155241794	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr4:155241794delG	uc003inw.2	-	14	3392	c.3392delC	c.(3391-3393)ACAfs	p.T1131fs		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1131	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGCTGTTACTGTCAGGATGAC	0.483			NA											39	150	---	---	---	---	NA	NA	NA	NA	NA
DNAH5	1767	broad.mit.edu	37	5	13766239	13766239	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:13766239delG	uc003jfd.2	-	59	9989	c.9947delC	c.(9946-9948)CCTfs	p.P3316fs	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3316	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GATGAGGTGAGGGGGGCGGCC	0.532			NA							Kartagener_syndrome				71	135	---	---	---	---	NA	NA	NA	NA	NA
THBS4	7060	broad.mit.edu	37	5	79372774	79372776	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	TGA	TGA	-	-	TGA	TGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:79372774_79372776delTGA	uc003kgh.2	+	17	2312_2314	c.1989_1991delTGA	c.(1987-1992)TGTGAT>TGT	p.D668del	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	668	TSP type-3 7.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GTGACGAGTGTGATGATGATGAT	0.562			NA											8	322	---	---	---	---	NA	NA	NA	NA	NA
PCDHGA2	56113	broad.mit.edu	37	5	140719292	140719292	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr5:140719292delC	uc003ljk.1	+	1	939	c.754delC	c.(754-756)CCGfs	p.P252fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Frame_Shift_Del_p.P252fs	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	252	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATAAGCATTCCGGAGAATAC	0.552			NA											41	62	---	---	---	---	NA	NA	NA	NA	NA
BTN3A1	11119	broad.mit.edu	37	6	26411336	26411336	+	Splice_Site	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:26411336delG	uc003nhv.2	+	8	1333	c.965_splice	c.e8-1	p.R322_splice	BTN3A1_uc011dkj.1_Splice_Site_p.R322_splice|BTN3A1_uc011dkk.1_Splice_Site_p.R270_splice|BTN3A1_uc010jqj.2_Splice_Site_p.R322_splice	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a						lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TTTCATTGTAGGGGGAGAGAG	0.393			NA											16	137	---	---	---	---	NA	NA	NA	NA	NA
TCP10	6953	broad.mit.edu	37	6	167791442	167791442	+	Splice_Site	DEL	C	C	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr6:167791442delC	uc003qvv.1	-	4	629	c.417_splice	c.e4+1	p.K139_splice	TCP10_uc003qvu.2_Splice_Site_p.K139_splice|TCP10_uc003qvw.2_Splice_Site_p.K115_splice	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10							cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		CGAAGGGTCACCTTTGGAGGA	0.527			NA											10	132	---	---	---	---	NA	NA	NA	NA	NA
HECW1	23072	broad.mit.edu	37	7	43283514	43283514	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr7:43283514delC	uc003tid.1	+	3	615	c.10delC	c.(10-12)CACfs	p.H4fs	HECW1_uc011kbi.1_Frame_Shift_Del_p.H4fs|HECW1_uc003tie.1_Intron	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	4					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TATGCTGCTGCACCTGTGTAG	0.448			NA											21	63	---	---	---	---	NA	NA	NA	NA	NA
ANK1	286	broad.mit.edu	37	8	41552150	41552150	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chr8:41552150delG	uc003xok.2	-	28	3371	c.3287delC	c.(3286-3288)CCGfs	p.P1096fs	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Frame_Shift_Del_p.P412fs|ANK1_uc003xoi.2_Frame_Shift_Del_p.P1096fs|ANK1_uc003xoj.2_Frame_Shift_Del_p.P1096fs|ANK1_uc003xol.2_Frame_Shift_Del_p.P1096fs|ANK1_uc003xom.2_Frame_Shift_Del_p.P1137fs	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1096					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGCATTCTCCGGGAACGTTGC	0.632			NA											7	24	---	---	---	---	NA	NA	NA	NA	NA
FANCB	2187	broad.mit.edu	37	X	14871289	14871289	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:14871289delC	uc004cwg.1	-	6	1466	c.1198delG	c.(1198-1200)GTTfs	p.V400fs	FANCB_uc004cwh.1_Frame_Shift_Del_p.V400fs	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	400					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					GAAAAACAAACCTGTAAAGTA	0.308			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				9	28	---	---	---	---	NA	NA	NA	NA	NA
MAGEA6	4105	broad.mit.edu	37	X	151870201	151870201	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-7554-01A-11D-2036-08	TCGA-97-7554-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1279b038-abe8-4ac4-accb-8a566da2b2fc	e05893e7-9426-44cc-8f63-c4e6e4daf500	g.chrX:151870201delT	uc004ffq.1	+	3	1085	c.891delT	c.(889-891)CCTfs	p.P297fs	MAGEA6_uc004ffr.1_Frame_Shift_Del_p.P297fs|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	297	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGAGGACCTCGCATTTCCT	0.557			NA											39	346	---	---	---	---	NA	NA	NA	NA	NA
