Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AP4E1	23431	broad.mit.edu	37	15	51223057	51223057	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:51223057A>C	ENST00000261842.5	+	7	864	c.758A>C	c.(757-759)cAa>cCa	p.Q253P	AP4E1_ENST00000560508.1_Missense_Mutation_p.Q178P	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	253					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		ATTTTGAAGCAAGTAGTTGGA	0.388000													5	49					0	0	0.184627	0	0
APC	324	broad.mit.edu	37	5	112176102	112176102	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:112176102C>T	ENST00000457016.1	+	16	5191	c.4811C>T	c.(4810-4812)cCt>cTt	p.P1604L	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.P1604L|APC_ENST00000508376.2_Missense_Mutation_p.P1604L			P25054	APC_HUMAN	adenomatous polyposis coli	1604	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTACCTCCACCTGTGGCAAGG	0.423000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			36	177					0	0	0.225048	0	0
SCML1	6322	broad.mit.edu	37	X	17771464	17771464	+	Silent	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:17771464A>G	ENST00000380043.3	+	7	1189	c.861A>G	c.(859-861)ctA>ctG	p.L287L	SCML1_ENST00000380041.3_Silent_p.L314L|SCML1_ENST00000398080.1_Silent_p.L193L|SCML1_ENST00000380045.3_Silent_p.L193L	NM_006746.4	NP_006737.2	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 (Drosophila)	314	SAM.				anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)	10	Hepatocellular(33;0.183)					CTGTGAAGCTATGCTACTACA	0.458000													16	38					0	0	0.175082	0	0
CMYA5	202333	broad.mit.edu	37	5	79029704	79029704	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:79029704G>A	ENST00000446378.2	+	2	5147	c.5116G>A	c.(5116-5118)Gag>Aag	p.E1706K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1706						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATTGCTTAGGGAGGAATCTCA	0.453000													13	87					0	0	0.146539	0	0
HOOK1	51361	broad.mit.edu	37	1	60324150	60324150	+	Silent	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:60324150A>G	ENST00000371208.3	+	13	1550	c.1293A>G	c.(1291-1293)cgA>cgG	p.R431R	HOOK1_ENST00000465876.1_3'UTR|HOOK1_ENST00000395561.2_Silent_p.R389R	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	431	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					AAGAGCTTCGATGTTCACAAG	0.363000													3	21					0	0	0.150653	0	0
KIF5C	3800	broad.mit.edu	37	2	149806425	149806425	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:149806425G>A	ENST00000435030.1	+	9	1155	c.787G>A	c.(787-789)Gga>Aga	p.G263R	KIF5C_ENST00000414838.2_Missense_Mutation_p.G168R|KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000397413.1_Missense_Mutation_p.G31R			O60282	KIF5C_HUMAN	kinesin family member 5C	263	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		GTCTGCTCTTGGAAATGTGAT	0.448000													5	22					0	0	0.217242	0	0
DEAF1	10522	broad.mit.edu	37	11	674761	674761	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:674761C>A	ENST00000382409.3	-	10	1762	c.1278G>T	c.(1276-1278)ctG>ctT	p.L426L	RP11-754B17.1_ENST00000527799.1_RNA|DEAF1_ENST00000338675.6_Silent_p.L337L|DEAF1_ENST00000525904.1_5'UTR	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	426	Pro-rich.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GTGGGACCGCCAGCGCAGGCA	0.532000													11	22					1.58986e-06	1.95894e-06	0.069234	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43847848	43847848	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:43847848C>A	ENST00000389420.3	-	12	1621	c.1622G>T	c.(1621-1623)cGt>cTt	p.R541L	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.R541L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	541	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding	p.R541L(2)		breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TAGCCCATGACGGCAATGCTA	0.368000													4	53					0.150653	0.154001	0.150653	1	0
ADC	113451	broad.mit.edu	37	1	33567487	33567487	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:33567487C>A	ENST00000358680.3	+	8	1196	c.609C>A	c.(607-609)gcC>gcA	p.A203A	ADC_ENST00000398167.1_Intron|ADC_ENST00000373440.1_Silent_p.A203A|ADC_ENST00000484656.1_Intron|ADC_ENST00000373441.1_Intron|ADC_ENST00000373443.3_Intron|ADC_ENST00000294517.6_Intron			Q96A70	ADC_HUMAN	arginine decarboxylase	0					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	atttcattgccgtgtagcgct	0.433000													4	47					0.00024832	0.00027936	0.150653	1	0
HAVCR1	26762	broad.mit.edu	37	5	156476071	156476071	+	Silent	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:156476071T>A	ENST00000339252.3	-	4	1291	c.759A>T	c.(757-759)tcA>tcT	p.S253S	HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000544197.1_Silent_p.S253S|HAVCR1_ENST00000523175.1_Silent_p.S253S|HAVCR1_ENST00000425854.1_Silent_p.S253S|HAVCR1_ENST00000522693.1_Silent_p.S253S	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	248					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTACAATGGTGAGCTGGTGG	0.478000													14	93					0	0	0.119110	0	0
RAG2	5897	broad.mit.edu	37	11	36614774	36614774	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:36614774C>T	ENST00000311485.3	-	2	1106	c.945G>A	c.(943-945)aaG>aaA	p.K315K		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	315					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				CAAACCATATCTTGCTGTGCT	0.383000									Familial Hemophagocytic Lymphohistiocytosis				14	122					0	0	0.175082	0	0
COL2A1	1280	broad.mit.edu	37	12	48375180	48375180	+	Splice_Site	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:48375180C>T	ENST00000380518.3	-	37	2574		c.e37-1		COL2A1_ENST00000337299.6_Splice_Site|COL2A1_ENST00000493991.1_Splice_Site	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1						axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CAACTTCTCCCTGAGGGTGGG	0.662000													6	5					0	0	0.248553	0	0
SPTA1	6708	broad.mit.edu	37	1	158648262	158648262	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:158648262C>A	ENST00000368148.3	-	6	921	c.741G>T	c.(739-741)gaG>gaT	p.E247D	SPTA1_ENST00000368147.3_Missense_Mutation_p.E247D	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	247					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CACGAAGGCGCTCCCAGGCAG	0.448000													7	92					2.7689e-08	3.56001e-08	0.248553	1	0
GABRG1	2565	broad.mit.edu	37	4	46066479	46066479	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:46066479A>T	ENST00000295452.4	-	5	771	c.604T>A	c.(604-606)Tgt>Agt	p.C202S		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	202					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCCAGTGGACAGGAATGTTCA	0.269000													7	36					0	0	0.047766	0	0
IL25	64806	broad.mit.edu	37	14	23842337	23842337	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:23842337C>T	ENST00000329715.2	+	1	268	c.10C>T	c.(10-12)Cga>Tga	p.R4*	IL25_ENST00000397242.2_Intron	NM_022789.3	NP_073626.1	Q9H293	IL25_HUMAN	interleukin 25	4					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		GATGAGGGAGCGACCCAGATT	0.587000													9	57					0	0	0.080935	0	0
USH2A	7399	broad.mit.edu	37	1	216373437	216373437	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:216373437G>A	ENST00000366943.2	-	17	3729	c.3343C>T	c.(3343-3345)Ctg>Ttg	p.L1115L	USH2A_ENST00000307340.3_Silent_p.L1115L|RP5-1099E6.3_ENST00000420867.1_RNA|USH2A_ENST00000366942.3_Silent_p.L1115L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1115	Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATGGTAACAGGTCTGTGTCT	0.368000										HNSCC(13;0.011)			4	52					0	0	0.184627	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994373	140994373	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:140994373A>G	ENST00000285879.4	+	4	1469	c.1183A>G	c.(1183-1185)Aga>Gga	p.R395G	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	395							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCCCTGAGAGAACTCACAG	0.473000										HNSCC(15;0.026)			51	107					0	0	0.139131	0	0
MID1	4281	broad.mit.edu	37	X	10535314	10535314	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:10535314T>C	ENST00000317552.4	-	2	674	c.274A>G	c.(274-276)Agc>Ggc	p.S92G	MID1_ENST00000453318.2_Missense_Mutation_p.S92G|MID1_ENST00000380779.1_Missense_Mutation_p.S92G|MID1_ENST00000380787.1_Missense_Mutation_p.S92G|MID1_ENST00000380780.1_Missense_Mutation_p.S92G|MID1_ENST00000380782.2_Missense_Mutation_p.S92G|MID1_ENST00000380785.1_Missense_Mutation_p.S92G	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	92					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						TTGGGCCCGCTCACTGATGCT	0.607000													9	40					0	0	0.058154	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290891	141290891	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:141290891G>T	ENST00000247452.3	-	3	1230	c.883C>A	c.(883-885)Cca>Aca	p.P295T		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	295	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TCATAATATGGAGGAGAACTG	0.498000										HNSCC(46;0.14)			44	106					2.69774e-35	3.82488e-35	0.139131	1	0
ULBP3	79465	broad.mit.edu	37	6	150386651	150386651	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:150386651C>G	ENST00000367339.1	-	3	539	c.511G>C	c.(511-513)Gag>Cag	p.E171Q	ULBP3_ENST00000438272.2_Missense_Mutation_p.E171Q			Q9BZM4	N2DL3_HUMAN	UL16 binding protein 3	171	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation	anchored to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	9		Ovarian(120;0.12)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.45e-12)		TCCCACTTCTCTTTCATCCGC	0.507000													8	50					0	0	0.058154	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062057	41062057	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:41062057G>A	ENST00000352632.3	+	25	5238	c.5152G>A	c.(5152-5154)Gag>Aag	p.E1718K	SPTBN4_ENST00000392025.1_Missense_Mutation_p.E461K|SPTBN4_ENST00000338932.3_Missense_Mutation_p.E1718K|SPTBN4_ENST00000598249.1_Missense_Mutation_p.E1718K|SPTBN4_ENST00000392023.1_Missense_Mutation_p.E394K|SPTBN4_ENST00000595535.1_Missense_Mutation_p.E1718K			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1718					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTGGGTGAGGAGCGCCGGGT	0.657000													3	7					0	0	0.150653	0	0
FAT1	2195	broad.mit.edu	37	4	187510357	187510357	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:187510357A>G	ENST00000441802.2	-	27	13365	c.13156T>C	c.(13156-13158)Tca>Cca	p.S4386P		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4386					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ATCCAATCTGATGTATCCCAG	0.468000										HNSCC(5;0.00058)			21	127					0	0	0.083992	0	0
APBB1	322	broad.mit.edu	37	11	6424580	6424580	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:6424580C>T	ENST00000389906.2	-	5	1108	c.1009G>A	c.(1009-1011)Ggg>Agg	p.G337R	APBB1_ENST00000311051.3_Missense_Mutation_p.G337R|APBB1_ENST00000299402.6_Missense_Mutation_p.G337R|APBB1_ENST00000533407.1_Missense_Mutation_p.G78R|APBB1_ENST00000530885.1_Missense_Mutation_p.G117R	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	337					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GTCAACGTCCCCTCCTCAGGT	0.572000													20	98					0	0	0.264190	0	0
FN1	2335	broad.mit.edu	37	2	216271930	216271930	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:216271930A>T	ENST00000354785.4	-	18	3002	c.2633T>A	c.(2632-2634)aTc>aAc	p.I878N	FN1_ENST00000345488.5_Missense_Mutation_p.I878N|FN1_ENST00000446046.1_Missense_Mutation_p.I878N|FN1_ENST00000443816.1_Missense_Mutation_p.I878N|FN1_ENST00000432072.2_Missense_Mutation_p.I878N|FN1_ENST00000323926.6_Missense_Mutation_p.I878N|FN1_ENST00000336916.4_Missense_Mutation_p.I878N|FN1_ENST00000346544.3_Missense_Mutation_p.I878N|FN1_ENST00000359671.1_Missense_Mutation_p.I878N|FN1_ENST00000357009.2_Missense_Mutation_p.I878N|FN1_ENST00000421182.1_Missense_Mutation_p.I878N|FN1_ENST00000357867.4_Missense_Mutation_p.I878N|FN1_ENST00000356005.4_Missense_Mutation_p.I878N			P02751	FINC_HUMAN	fibronectin 1	878	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATAGATAGTGATGTTATACTG	0.438000													17	112					0	0	0.189662	0	0
GABRA4	2557	broad.mit.edu	37	4	46973176	46973176	+	Silent	SNP	C	C	A	rs147092196		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:46973176C>A	ENST00000264318.3	-	7	1780	c.798G>T	c.(796-798)ccG>ccT	p.P266P		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	266					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCATAATGCACGGAATATAGG	0.368000													4	35					0.00909568	0.00963072	0.150653	1	0
ASIC2	40	broad.mit.edu	37	17	31415962	31415962	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:31415962C>G	ENST00000225823.2	-	3	1778	c.906G>C	c.(904-906)caG>caC	p.Q302H	ASIC2_ENST00000359872.6_Missense_Mutation_p.Q251H|ASIC2_ENST00000448983.1_5'UTR	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	251					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	GTGGCTCAGACTGACTGTGGA	0.532000													3	57					0	0	0.150653	0	0
VGLL1	51442	broad.mit.edu	37	X	135631059	135631059	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:135631059A>T	ENST00000370634.3	+	3	696	c.526A>T	c.(526-528)Aga>Tga	p.R176*		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					CCAGCAAGACAGATGCCTAGC	0.612000													41	68					0	0	0.131918	0	0
GPR139	124274	broad.mit.edu	37	16	20043715	20043715	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:20043715T>C	ENST00000570682.1	-	2	704	c.404A>G	c.(403-405)aAg>aGg	p.K135R		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	135						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CGTGTGGTACTTGAGCGGGTG	0.498000													7	70					0	0	0.248553	0	0
NMD3	51068	broad.mit.edu	37	3	160952566	160952566	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:160952566C>G	ENST00000460469.1	+	5	864	c.409C>G	c.(409-411)Cag>Gag	p.Q137E	NMD3_ENST00000472947.1_Missense_Mutation_p.Q137E|NMD3_ENST00000351193.2_Missense_Mutation_p.Q137E|NMD3_ENST00000478160.1_3'UTR			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	137					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TTATGTTGTTCAGTCCCAAAT	0.383000													5	119					0	0	0.184627	0	0
YLPM1	56252	broad.mit.edu	37	14	75276211	75276211	+	Silent	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:75276211A>T	ENST00000325680.7	+	7	4774	c.4650A>T	c.(4648-4650)ccA>ccT	p.P1550P	YLPM1_ENST00000238571.3_Silent_p.P1355P|YLPM1_ENST00000552421.1_Silent_p.P844P	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1355	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CACCAcctccacctcctccac	0.522000													4	21					0	0	0.150653	0	0
ZFHX3	463	broad.mit.edu	37	16	72993498	72993498	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:72993498C>T	ENST00000268489.5	-	2	1219	c.547G>A	c.(547-549)Gac>Aac	p.D183N	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	183					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CACGAAGGGTCCCCTTGCTTG	0.637000													4	49					0	0	0.150653	0	0
GVINP1	387751	broad.mit.edu	37	11	6738832	6738832	+	RNA	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:6738832C>T	ENST00000526769.2	-	0	4372																											ATGGAGGAAGCTTCTTCCAGA	0.423000													6	5					0	0	0.217242	0	0
ATP13A4	84239	broad.mit.edu	37	3	193176932	193176932	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:193176932G>A	ENST00000342695.4	-	14	1934	c.1612C>T	c.(1612-1614)Ctt>Ttt	p.L538F	ATP13A4_ENST00000295548.3_Missense_Mutation_p.L538F|ATP13A4_ENST00000392443.3_Missense_Mutation_p.L519F	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	538					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCATCAAGAAGGATCAGAGAG	0.532000													13	99					0	0	0.119110	0	0
A2M	2	broad.mit.edu	37	12	9246133	9246133	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:9246133A>T	ENST00000318602.7	-	18	2475	c.2168T>A	c.(2167-2169)gTt>gAt	p.V723D		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	723	Bait region.|Inhibitory.				blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	AGGCTCTTCAACATGCACCAG	0.443000													11	56					0	0	0.069234	0	0
FAM135B	51059	broad.mit.edu	37	8	139153550	139153550	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:139153550G>T	ENST00000395297.1	-	17	3851	c.3681C>A	c.(3679-3681)gtC>gtA	p.V1227V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1227										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCGTGTGAGGACCGATCGGA	0.552000										HNSCC(54;0.14)			19	105					4.4004e-07	5.48725e-07	0.083992	1	0
ADAM9	8754	broad.mit.edu	37	8	38884267	38884267	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:38884267T>A	ENST00000487273.2	+	11	1146	c.1068T>A	c.(1066-1068)aaT>aaA	p.N356K		NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	356	Peptidase M12B.				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			TTGGAATGAATCACGATGATG	0.418000													13	98					0	0	0.105934	0	0
QKI	9444	broad.mit.edu	37	6	163956145	163956145	+	Silent	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:163956145A>G	ENST00000361752.3	+	4	1085	c.534A>G	c.(532-534)ttA>ttG	p.L178L	QKI_ENST00000275262.7_Silent_p.L178L|QKI_ENST00000392127.2_Silent_p.L178L|QKI_ENST00000453779.2_Silent_p.L178L|QKI_ENST00000424802.3_Silent_p.L178L|QKI_ENST00000361195.2_Silent_p.L178L	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	178					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TGAAGAAATTATTGGTACCTG	0.338000													17	53					0	0	0.175082	0	0
GLDN	342035	broad.mit.edu	37	15	51696845	51696845	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:51696845T>C	ENST00000335449.6	+	10	1606	c.1550T>C	c.(1549-1551)cTt>cCt	p.L517P	GLDN_ENST00000396399.2_Missense_Mutation_p.L393P	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	517	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		CAGTCTGTTCTTGCCATGTTA	0.378000													8	69					0	0	0.047766	0	0
ERC1	23085	broad.mit.edu	37	12	1553905	1553905	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:1553905A>C	ENST00000397203.2	+	18	3608	c.3202A>C	c.(3202-3204)Acc>Ccc	p.T1068P	ERC1_ENST00000589028.1_Missense_Mutation_p.T1068P|ERC1_ENST00000546231.2_Missense_Mutation_p.T1072P|ERC1_ENST00000543086.3_Missense_Mutation_p.T1040P|ERC1_ENST00000355446.5_Missense_Mutation_p.T1068P|ERC1_ENST00000360905.4_Missense_Mutation_p.T1068P			Q8IUD2	RB6I2_HUMAN	ELKS/RAB6-interacting/CAST family member 1	1068	FIP-RBD.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			NS(1)|breast(2)|cervix(2)|endometrium(2)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GCAGAAGATGACCCGGGGGCA	0.552000													6	54					0	0	0.038147	0	0
POM121L12	285877	broad.mit.edu	37	7	53103754	53103754	+	Silent	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:53103754A>T	ENST00000408890.4	+	1	406	c.390A>T	c.(388-390)ccA>ccT	p.P130P		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	130										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCTGGAACCCAGGACGGACCT	0.716000													3	23					0	0	0.115264	0	0
NME8	51314	broad.mit.edu	37	7	37927918	37927918	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:37927918C>A	ENST00000199447.4	+	15	1659	c.1287C>A	c.(1285-1287)aaC>aaA	p.N429K	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.N429K	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	429	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TGCCGGTCAACCAGTTGTATG	0.373000													8	125					1.06961e-07	1.35006e-07	0.038147	1	0
NPHS1	4868	broad.mit.edu	37	19	36339163	36339163	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:36339163T>C	ENST00000378910.5	-	10	1306	c.1307A>G	c.(1306-1308)aAc>aGc	p.N436S	NPHS1_ENST00000353632.6_Missense_Mutation_p.N436S	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	436					cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACATTTTACGTTCAGGATGAG	0.577000													6	54					0	0	0.217242	0	0
BARX2	8538	broad.mit.edu	37	11	129306661	129306661	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:129306661G>C	ENST00000281437.4	+	2	299	c.203G>C	c.(202-204)cGg>cCg	p.R68P	BARX2_ENST00000526127.1_5'UTR	NM_003658.4	NP_003649.2	Q9UMQ3	BARX2_HUMAN	BARX homeobox 2	68										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CCTTCCCTGCGGGCATATCCG	0.672000													5	102					0	0	0.217242	0	0
RP11-782C8.2	0	broad.mit.edu	37	1	143163614	143163614	+	RNA	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:143163614T>A	ENST00000412204.2	-	0	2503				RP11-782C8.4_ENST00000424474.2_lincRNA|RP11-782C8.1_ENST00000438000.1_lincRNA																							ttctttcctctgcttggtcta	0.488000													2	3					0	0	0.115264	0	0
RAVER2	55225	broad.mit.edu	37	1	65243492	65243492	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:65243492T>C	ENST00000294428.3	+	3	581	c.503T>C	c.(502-504)aTt>aCt	p.I168T	RAVER2_ENST00000371072.4_Missense_Mutation_p.I168T			Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	168	RRM 2.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						TATGGAAATATTGAGAGATGT	0.403000													28	312					0	0	0.116897	0	0
REV3L	5980	broad.mit.edu	37	6	111695267	111695267	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:111695267A>G	ENST00000435970.1	-	15	4873	c.4057T>C	c.(4057-4059)Tgc>Cgc	p.C1353R	REV3L_ENST00000358835.3_Missense_Mutation_p.C1431R|REV3L_ENST00000368802.3_Missense_Mutation_p.C1431R|REV3L_ENST00000368805.1_Missense_Mutation_p.C1431R			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1431					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCCGCTATGCACACAATCTGC	0.418000								DNA polymerases (catalytic subunits)					4	116					0	0	0.184627	0	0
NXPE2	120406	broad.mit.edu	37	11	114569284	114569284	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:114569284C>A	ENST00000375475.5	+	3	748	c.650C>A	c.(649-651)aCt>aAt	p.T217N	NXPE2_ENST00000389586.4_Missense_Mutation_p.T217N					neurexophilin and PC-esterase domain family, member 2																		ATCATCTTCACTGGCCTGTTT	0.517000													18	58					1.56452e-12	2.11671e-12	0.189662	1	0
MYH7	4625	broad.mit.edu	37	14	23884965	23884965	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:23884965C>A	ENST00000355349.3	-	35	5192	c.5030G>T	c.(5029-5031)cGc>cTc	p.R1677L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1677					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1677H(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGGTTGTTGCGCCGCTCCAC	0.612000													4	49					2.56e-06	3.10804e-06	0.150653	1	0
SPTA1	6708	broad.mit.edu	37	1	158585142	158585142	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:158585142C>A	ENST00000368148.3	-	48	6832	c.6652G>T	c.(6652-6654)Gac>Tac	p.D2218Y	SPTA1_ENST00000368147.3_Missense_Mutation_p.D2215Y	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2218					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCCCCCAGGTCCACAATCTTG	0.498000													35	288					2.04263e-09	2.6846e-09	0.203993	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137259	40137259	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:40137259C>A	ENST00000278198.2	-	2	2547	c.584G>T	c.(583-585)gGt>gTt	p.G195V	LRRC4C_ENST00000530763.1_Missense_Mutation_p.G195V|LRRC4C_ENST00000527150.1_Missense_Mutation_p.G195V|LRRC4C_ENST00000528697.1_Missense_Mutation_p.G195V			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	195					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTTGGACAGACCTTCAAAGGC	0.443000													17	84					1.99824e-07	2.5145e-07	0.160694	1	0
OBSCN	84033	broad.mit.edu	37	1	228444509	228444509	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:228444509C>T	ENST00000570156.2	+	16	4817	c.4743C>T	c.(4741-4743)cgC>cgT	p.R1581R	OBSCN_ENST00000422127.1_Silent_p.R1489R|OBSCN_ENST00000284548.11_Silent_p.R1489R|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Silent_p.R53R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	562	Ig-like 16.			VRM -> MRV (in Ref. 1; CAC85750).	apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGAAAGTGCGCATGGAGGCTG	0.682000													6	34					0	0	0.248553	0	0
OR2D3	120775	broad.mit.edu	37	11	6943219	6943219	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:6943219G>T	ENST00000317834.3	+	1	1015	c.987G>T	c.(985-987)agG>agT	p.R329S		NM_001004684.1	NP_001004684.1	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D, member 3	329					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|prostate(3)|skin(1)|stomach(1)	27		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCTCTCATAGGCAGTGACCTC	0.403000													5	61					0.014758	0.0153899	0.184627	1	0
BTK	695	broad.mit.edu	37	X	100617171	100617171	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:100617171T>A	ENST00000308731.7	-	7	741	c.578A>T	c.(577-579)gAg>gTg	p.E193V	BTK_ENST00000372880.1_Missense_Mutation_p.E193V	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	193					calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTGGTCCTCCTCAGGCGTTGG	0.473000									Agammaglobulinemia, X-linked				7	20					0	0	0.047766	0	0
KCNK10	54207	broad.mit.edu	37	14	88652311	88652311	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:88652311C>A	ENST00000340700.5	-	7	1636	c.1185G>T	c.(1183-1185)gaG>gaT	p.E395D	KCNK10_ENST00000312350.5_Missense_Mutation_p.E400D|KCNK10_ENST00000319231.5_Missense_Mutation_p.E400D	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	395					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						CAGAGCGCTTCTCGGGGGACA	0.677000													9	34					0.000673444	0.000747469	0.069234	1	0
COL11A1	1301	broad.mit.edu	37	1	103487272	103487272	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:103487272C>T	ENST00000358392.2	-	9	1652	c.1335G>A	c.(1333-1335)gtG>gtA	p.V445V	COL11A1_ENST00000512756.1_Silent_p.V317V|COL11A1_ENST00000370096.3_Silent_p.V433V|COL11A1_ENST00000353414.4_Silent_p.V394V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	433	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGGCTCAACCACTGCTGGTT	0.363000													7	23					0	0	0.038147	0	0
MYO5B	4645	broad.mit.edu	37	18	47375947	47375947	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:47375947C>T	ENST00000285039.7	-	32	4604	c.4305G>A	c.(4303-4305)caG>caA	p.Q1435Q	MYO5B_ENST00000324581.6_Silent_p.Q550Q|MYO5B_ENST00000592688.1_Silent_p.Q5Q|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1435					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CTTCTAGGTCCTGGGCTTTCT	0.488000													9	707					0	0	0.080935	0	0
SCN2A	6326	broad.mit.edu	37	2	166201109	166201109	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:166201109G>T	ENST00000357398.3	+	16	2897	c.2607G>T	c.(2605-2607)atG>atT	p.M869I	SCN2A_ENST00000375427.2_Missense_Mutation_p.M869I|SCN2A_ENST00000375437.2_Missense_Mutation_p.M869I|SCN2A_ENST00000283256.6_Missense_Mutation_p.M869I			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	869					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CTCTAAATATGCTAATTAAGA	0.413000													16	65					3.45872e-05	4.04494e-05	0.146539	1	0
RTKN2	219790	broad.mit.edu	37	10	63958111	63958111	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:63958111A>C	ENST00000373789.3	-	12	1482	c.1386T>G	c.(1384-1386)caT>caG	p.H462Q	RTKN2_ENST00000395265.1_Missense_Mutation_p.H483Q|RTKN2_ENST00000315289.2_Missense_Mutation_p.H264Q	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	462			H -> R (in dbSNP:rs3125734).		signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AGGATTCTTCATGCTGACCAA	0.378000													3	92					0	0	0.115264	0	0
DOCK4	9732	broad.mit.edu	37	7	111409724	111409724	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:111409724T>A	ENST00000428084.1	-	37	3961	c.3689A>T	c.(3688-3690)tAt>tTt	p.Y1230F	DOCK4_ENST00000494651.2_Missense_Mutation_p.Y104F|DOCK4_ENST00000437633.1_Missense_Mutation_p.Y1221F			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1221	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GAGGAGGGTATATGCAGCTTC	0.507000													9	30					0	0	0.058154	0	0
C5AR1	728	broad.mit.edu	37	19	47823817	47823817	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:47823817G>A	ENST00000355085.3	+	2	805	c.783G>A	c.(781-783)acG>acA	p.T261T		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	261					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		ACCAGGTGACGGGGATAATGA	0.577000													6	38					0	0	0.217242	0	0
YTHDF3	253943	broad.mit.edu	37	8	64098705	64098705	+	Splice_Site	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:64098705G>C	ENST00000542911.2	+	5	389		c.e5-1		YTHDF3_ENST00000539294.1_Intron|YTHDF3_ENST00000521674.1_Splice_Site|YTHDF3_ENST00000517371.1_Intron			Q7Z739	YTHD3_HUMAN	YTH domain family, member 3													Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			TTGTTTTGCAGAGTAACAGCT	0.363000													3	29					0	0	0.115264	0	0
OR4A15	81328	broad.mit.edu	37	11	55135507	55135507	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:55135507G>A	ENST00000314706.3	+	1	148	c.148G>A	c.(148-150)Gag>Aag	p.E50K		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ACAGAACCCTGAGGGGCAAAA	0.438000													8	54					0	0	0.038147	0	0
DACH2	117154	broad.mit.edu	37	X	85404023	85404023	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:85404023G>A	ENST00000373131.1	+	1	562	c.399G>A	c.(397-399)ggG>ggA	p.G133G	DACH2_ENST00000373125.4_Silent_p.G133G	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	133	DACHbox-N.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TCCTCCGCGGGCTGGGGGCCA	0.567000													12	20					0	0	0.132662	0	0
TCL6	27004	broad.mit.edu	37	14	96134711	96134711	+	RNA	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:96134711G>A	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		ACAGCAGCATGAAAAACAGGC	0.512000			T	TRA@	T-ALL								5	58					0	0	0.217242	0	0
CACNA1E	777	broad.mit.edu	37	1	181701820	181701820	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:181701820C>T	ENST00000526775.1	+	19	2706	c.2541C>T	c.(2539-2541)gcC>gcT	p.A847A	CACNA1E_ENST00000367567.4_Silent_p.A473A|CACNA1E_ENST00000360108.3_Silent_p.A847A|CACNA1E_ENST00000367573.2_Silent_p.A866A|CACNA1E_ENST00000358338.5_Silent_p.A798A|CACNA1E_ENST00000367570.1_Silent_p.A866A|CACNA1E_ENST00000357570.5_Silent_p.A817A	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	866					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GATCCAGTGCCCTGGACAACC	0.672000													3	15					0	0	0.150653	0	0
ZFHX4	79776	broad.mit.edu	37	8	77690536	77690536	+	Silent	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:77690536G>C	ENST00000521891.2	+	4	3634	c.3186G>C	c.(3184-3186)ctG>ctC	p.L1062L	ZFHX4_ENST00000517683.1_3'UTR|ZFHX4_ENST00000455469.2_Silent_p.L1036L|ZFHX4_ENST00000050961.6_Silent_p.L1036L|ZFHX4_ENST00000518282.1_Silent_p.L1036L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1036						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTTGAATCTGGTACAACATG	0.537000										HNSCC(33;0.089)			7	119					0	0	0.248553	0	0
IGHV3-64	28414	broad.mit.edu	37	14	107113929	107113929	+	RNA	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:107113929A>C	ENST00000454421.2	-	0	242																											TGGCGGACCCAGTGCATAGCA	0.547000													10	211					0	0	0.069234	0	0
COL1A2	1278	broad.mit.edu	37	7	94041394	94041394	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:94041394C>A	ENST00000297268.6	+	24	1836	c.1365C>A	c.(1363-1365)tcC>tcA	p.S455S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	455					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTCCTGGTTCCCCTGGAAATA	0.388000										HNSCC(75;0.22)			3	30					2.56e-06	3.10804e-06	0.150653	1	0
CSMD3	114788	broad.mit.edu	37	8	113504781	113504781	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:113504781G>A	ENST00000297405.5	-	31	5459	c.5215C>T	c.(5215-5217)Ctc>Ttc	p.L1739F	CSMD3_ENST00000352409.3_Missense_Mutation_p.L1739F|CSMD3_ENST00000343508.3_Missense_Mutation_p.L1699F|CSMD3_ENST00000455883.2_Missense_Mutation_p.L1635F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1739	Sushi 9.					integral to membrane|plasma membrane		p.L1739F(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATACAGGTGAGTGTTGAATAA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	80					0	0	0.091800	0	0
TEX13A	56157	broad.mit.edu	37	X	104463837	104463837	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:104463837C>A	ENST00000372578.3	-	3	1152	c.1041G>T	c.(1039-1041)atG>atT	p.M347I	IL1RAPL2_ENST00000372582.1_Intron|TEX13A_ENST00000372575.1_Missense_Mutation_p.M347I|IL1RAPL2_ENST00000344799.4_Intron|TEX13A_ENST00000413579.1_Missense_Mutation_p.G347W	NM_031274.3	NP_112564.1	Q9BXU3	TX13A_HUMAN	testis expressed 13A	0						intracellular	zinc ion binding			large_intestine(5)|ovary(2)|upper_aerodigestive_tract(1)	8						TGGGGCCCCCCATCAGACCAC	0.562000													11	32					3.86212e-05	4.46625e-05	0.069234	1	0
GJA10	84694	broad.mit.edu	37	6	90605746	90605746	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:90605746C>T	ENST00000369352.1	+	1	1559	c.1559C>T	c.(1558-1560)gCa>gTa	p.A520V		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	520					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GACAGAGAGGCAGATGGAGGG	0.343000													4	110					0	0	0.150653	0	0
SPTA1	6708	broad.mit.edu	37	1	158623080	158623080	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:158623080C>T	ENST00000368148.3	-	22	3352	c.3172G>A	c.(3172-3174)Gag>Aag	p.E1058K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1058K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1058					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCAATCTGCTCCTGGCGCTGG	0.522000													4	90					0	0	0.150653	0	0
RYR3	6263	broad.mit.edu	37	15	34112970	34112970	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:34112970G>C	ENST00000389232.4	+	78	10842	c.10772G>C	c.(10771-10773)gGt>gCt	p.G3591A	RYR3_ENST00000415757.3_Missense_Mutation_p.G3586A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3591					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGTCAAAGTGGTGAGGATGAA	0.428000													3	13					0	0	0.115264	0	0
OR13A1	79290	broad.mit.edu	37	10	45799860	45799860	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:45799860C>T	ENST00000553795.1	-	4	319	c.11G>A	c.(10-12)tGg>tAg	p.W4*	OR13A1_ENST00000536058.1_Nonsense_Mutation_p.W4*|OR13A1_ENST00000374401.2_Nonsense_Mutation_p.W4*	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						ACTCTCCATCCACAGCTTCAT	0.507000													6	49					0	0	0.038147	0	0
PAX8	7849	broad.mit.edu	37	2	114002157	114002157	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:114002157G>C	ENST00000429538.3	-	4	430	c.236C>G	c.(235-237)tCc>tGc	p.S79C	AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000422956.1_RNA|AC016683.6_ENST00000436293.2_RNA|AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000556070.1_RNA|PAX8_ENST00000263335.7_Missense_Mutation_p.S79C|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000445745.1_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.S79C|PAX8_ENST00000348715.5_Missense_Mutation_p.S79C|PAX8_ENST00000263334.5_Missense_Mutation_p.S79C	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	79	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						CTTGGGCTTGGAGCCCCCTAT	0.557000			T	PPARG	follicular thyroid		Thyroid dysgenesis						15	142					0	0	0.189662	0	0
SEC16A	9919	broad.mit.edu	37	9	139353685	139353685	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:139353685T>C	ENST00000313050.7	-	15	5383	c.5310A>G	c.(5308-5310)ccA>ccG	p.P1770P	SEC16A_ENST00000371706.3_Silent_p.P1592P|SEC16A_ENST00000431893.2_Silent_p.P1592P|SEC16A_ENST00000290037.6_Silent_p.P1592P	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	1592	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		ACTTTAAGAATGGCAAACTGT	0.483000													5	24					0	0	0.184627	0	0
CARD16	114769	broad.mit.edu	37	11	104915276	104915276	+	Missense_Mutation	SNP	C	C	G	rs61739405		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:104915276C>G	ENST00000375706.2	-	2	134	c.117G>C	c.(115-117)gaG>gaC	p.E39D	CASP1_ENST00000415981.2_Intron|CASP1_ENST00000593315.1_Intron|CASP1_ENST00000598974.1_Intron|CARD16_ENST00000375704.3_Missense_Mutation_p.E39D|CASP1_ENST00000594519.1_Intron|CARD16_ENST00000525374.1_Missense_Mutation_p.E39D	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						CTTTCTCCATCTCTTCCTGGT	0.423000													11	413					0	0	0.069234	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752740	62752740	+	RNA	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:62752740C>G	ENST00000331425.6	-	0	695					NR_003952.1																						TTCCTCACATCTATATGGTTT	0.403000													5	25					0	0	0.038147	0	0
NOX3	50508	broad.mit.edu	37	6	155776924	155776924	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:155776924C>T	ENST00000159060.2	-	1	113	c.11G>A	c.(10-12)tGc>tAc	p.C4Y		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	4							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CAAAATCCAGCACCCCATCAT	0.378000													5	34					0	0	0.184627	0	0
ZNF670	93474	broad.mit.edu	37	1	247200850	247200850	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:247200850C>T	ENST00000366503.2	-	4	1229	c.1071G>A	c.(1069-1071)agG>agA	p.R357R		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			CAGTATGAGTCCTTTCATGGC	0.408000													36	53					0	0	0.173368	0	0
CMYA5	202333	broad.mit.edu	37	5	79029705	79029705	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:79029705A>T	ENST00000446378.2	+	2	5148	c.5117A>T	c.(5116-5118)gAg>gTg	p.E1706V		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1706						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTGCTTAGGGAGGAATCTCAG	0.448000													13	87					0	0	0.146539	0	0
GPR112	139378	broad.mit.edu	37	X	135405117	135405117	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:135405117G>C	ENST00000394143.1	+	5	542	c.251G>C	c.(250-252)gGc>gCc	p.G84A	GPR112_ENST00000394141.1_Intron|GPR112_ENST00000412101.1_Intron|GPR112_ENST00000370652.1_Missense_Mutation_p.G84A|GPR112_ENST00000287534.4_Missense_Mutation_p.G21A	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	84					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GCCCTCCTGGGCAGAGAAGAC	0.448000													76	81					0	0	0.139131	0	0
GRIA4	2893	broad.mit.edu	37	11	105623720	105623720	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:105623720T>A	ENST00000393127.2	+	4	707	c.261T>A	c.(259-261)taT>taA	p.Y87*	GRIA4_ENST00000428631.2_Nonsense_Mutation_p.Y87*|GRIA4_ENST00000393125.2_Nonsense_Mutation_p.Y87*|GRIA4_ENST00000530497.1_Nonsense_Mutation_p.Y87*|GRIA4_ENST00000282499.5_Nonsense_Mutation_p.Y87*|GRIA4_ENST00000525187.1_Nonsense_Mutation_p.Y87*	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	87					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GTTCCCAGTATTCTAGAGGAG	0.378000													13	117					0	0	0.146539	0	0
POLL	27343	broad.mit.edu	37	10	103343395	103343395	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:103343395T>G	ENST00000370162.3	-	6	1429	c.935A>C	c.(934-936)aAa>aCa	p.K312T	DPCD_ENST00000470165.1_Intron|POLL_ENST00000370158.3_Missense_Mutation_p.K37T|POLL_ENST00000370172.1_Missense_Mutation_p.K224T|POLL_ENST00000299206.4_Missense_Mutation_p.K312T|POLL_ENST00000370169.1_Missense_Mutation_p.K312T|POLL_ENST00000456836.2_Missense_Mutation_p.K49T|POLL_ENST00000339310.3_Missense_Mutation_p.K35T|DPCD_ENST00000416979.2_Intron|POLL_ENST00000436284.2_Missense_Mutation_p.K170Q	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	312					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CTCTATGATTTTCTCAGCCAT	0.552000								DNA polymerases (catalytic subunits)					3	14					0	0	0.150653	0	0
C2orf78	388960	broad.mit.edu	37	2	74040815	74040815	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:74040815C>G	ENST00000409561.1	+	2	430	c.309C>G	c.(307-309)agC>agG	p.S103R		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	103	Ser-rich.									cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						AACATTCTAGCACAACTATGT	0.522000													12	75					0	0	0.105934	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683242	50683242	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:50683242C>A	ENST00000008391.3	+	2	681	c.453C>A	c.(451-453)ggC>ggA	p.G151G		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	151							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TGAGCCATGGCTCTCAGTATG	0.642000													29	124					1.45844e-13	1.99271e-13	0.173368	1	0
KCNS3	3790	broad.mit.edu	37	2	18113551	18113551	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:18113551G>A	ENST00000403915.1	+	3	1727	c.1276G>A	c.(1276-1278)Gag>Aag	p.E426K	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Missense_Mutation_p.E426K			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	426					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCAGTGCAGTGAGGATGCACC	0.463000													23	139					0	0	0.264190	0	0
PCIF1	63935	broad.mit.edu	37	20	44567888	44567888	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:44567888G>T	ENST00000372409.3	+	4	523	c.159G>T	c.(157-159)tgG>tgT	p.W53C		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	53	WW.					nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						AGAAGTGCTGGAGCCGGAGGG	0.617000													4	10					0.014758	0.0153899	0.184627	1	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000377425.4_Intron|AQP7_ENST00000537089.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	59					0	0	0.217242	0	0
OR2D3	120775	broad.mit.edu	37	11	6943218	6943218	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:6943218G>T	ENST00000317834.3	+	1	1014	c.986G>T	c.(985-987)aGg>aTg	p.R329M		NM_001004684.1	NP_001004684.1	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D, member 3	329					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|prostate(3)|skin(1)|stomach(1)	27		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTCTCTCATAGGCAGTGACCT	0.403000													5	62					0.014758	0.0153899	0.184627	1	0
POLN	353497	broad.mit.edu	37	4	2230953	2230953	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:2230953T>C	ENST00000511885.2	-	3	359	c.6A>G	c.(4-6)gaA>gaG	p.E2E	POLN_ENST00000382865.1_Silent_p.E2E|POLN_ENST00000515357.1_5'UTR|HAUS3_ENST00000506763.1_Intron|HAUS3_ENST00000243706.4_3'UTR			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	2					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			CCTCATAATTTTCCATTTTCA	0.313000								DNA polymerases (catalytic subunits)					6	35					0	0	0.248553	0	0
WIBG	84305	broad.mit.edu	37	12	56297212	56297212	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:56297212C>A	ENST00000557259.1	-	2	348	c.128G>T	c.(127-129)gGa>gTa	p.G43V	WIBG_ENST00000547925.1_Missense_Mutation_p.G44V|WIBG_ENST00000302533.6_5'UTR|WIBG_ENST00000408946.2_Silent_p.R30R|WIBG_ENST00000398213.4_Silent_p.R29R			Q9BRP8	WIBG_HUMAN	within bgcn homolog (Drosophila)	0					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|exon-exon junction complex|nucleolus|nucleoplasm	protein binding|ribosome binding|RNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CTTTCACCCTCCGCTGCTTGC	0.468000													4	53					0.150653	0.154001	0.150653	1	0
OR4A16	81327	broad.mit.edu	37	11	55110813	55110813	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:55110813C>T	ENST00000314721.2	+	1	187	c.137C>T	c.(136-138)aCt>aTt	p.T46I		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATTTGGGTGACTACTATTGGC	0.433000													12	56					0	0	0.093190	0	0
RALBP1	10928	broad.mit.edu	37	18	9517288	9517288	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:9517288C>T	ENST00000019317.4	+	3	913	c.690C>T	c.(688-690)atC>atT	p.I230I	RALBP1_ENST00000383432.3_Silent_p.I230I			Q15311	RBP1_HUMAN	ralA binding protein 1	230	Rho-GAP.				chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	14						GTGAAGGCATCTACAGAGTAT	0.393000													4	66					0	0	0.150653	0	0
DCDC1	341019	broad.mit.edu	37	11	30930622	30930622	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:30930622C>G	ENST00000597505.1	-	27	3788	c.3789G>C	c.(3787-3789)tgG>tgC	p.W1263C	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.W342C			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TCATGTAATGCCACTTTTGAT	0.383000													4	37					0	0	0.150653	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996946	19996946	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:19996946T>A	ENST00000391403.2	-	1	932	c.829A>T	c.(829-831)Aat>Tat	p.N277Y		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	277						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TTTGGAGGATTATCTAAGTAA	0.348000													5	237					0	0	0.217242	0	0
CAB39	51719	broad.mit.edu	37	2	231682502	231682502	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:231682502T>G	ENST00000258418.5	+	8	1156	c.727T>G	c.(727-729)Ttc>Gtc	p.F243V	CAB39_ENST00000410084.3_Missense_Mutation_p.F243V|CAB39_ENST00000409788.3_Missense_Mutation_p.F243V	NM_016289.3	NP_057373.1	Q9Y376	CAB39_HUMAN	calcium binding protein 39	243					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)|large_intestine(1)|skin(1)	3		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		TAGACACAACTTCACAATTAT	0.333000													4	41					0	0	0.184627	0	0
R3HDM1	23518	broad.mit.edu	37	2	136481642	136481642	+	Missense_Mutation	SNP	G	G	A	rs143951307		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:136481642G>A	ENST00000264160.4	+	26	3450	c.3080G>A	c.(3079-3081)cGt>cAt	p.R1027H	R3HDM1_ENST00000329971.3_Missense_Mutation_p.R898H|R3HDM1_ENST00000409478.1_Missense_Mutation_p.R899H|R3HDM1_ENST00000409606.1_Missense_Mutation_p.R1028H|R3HDM1_ENST00000410054.1_Missense_Mutation_p.R972H	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	1027							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		CAACCACGTCGTCACCCCCTC	0.562000													8	62					0	0	0.047766	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003577	52003577	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:52003577C>A	ENST00000598614.1	-	1	50	c.51G>T	c.(49-51)tgG>tgT	p.W17C	SIGLEC12_ENST00000291707.3_Intron	NM_033329.1	NP_201586.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	0					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GAGGGTCAGCCCAGCCCCCAC	0.607000													4	33					2.56e-06	3.10804e-06	0.150653	1	0
LHX9	56956	broad.mit.edu	37	1	197887011	197887011	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:197887011A>T	ENST00000367390.3	+	2	58	c.31A>T	c.(31-33)Atg>Ttg	p.M11L	LHX9_ENST00000606127.1_3'UTR|LHX9_ENST00000337020.2_Missense_Mutation_p.M20L|LHX9_ENST00000367387.4_Missense_Mutation_p.M20L|LHX9_ENST00000367391.1_Missense_Mutation_p.M11L|LHX9_ENST00000561173.1_Missense_Mutation_p.M26L	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	20					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						CCCCCCAGCCATGCTCTTTCA	0.602000													8	109					0	0	0.038147	0	0
BRINP1	1620	broad.mit.edu	37	9	122004416	122004416	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:122004416G>A	ENST00000265922.3	-	4	949	c.488C>T	c.(487-489)gCt>gTt	p.A163V	DBC1_ENST00000373964.2_Missense_Mutation_p.A163V	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		163	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CTGGTGCAGAGCTTCAACACT	0.488000													5	50					0	0	0.184627	0	0
OR4N2	390429	broad.mit.edu	37	14	20296219	20296219	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:20296219C>T	ENST00000315947.1	+	1	612	c.612C>T	c.(610-612)ggC>ggT	p.G204G	OR4N2_ENST00000568211.1_3'UTR	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCAACAGTGGCCTGATGACAC	0.512000													10	122					0	0	0.080935	0	0
KIAA1257	57501	broad.mit.edu	37	3	128711899	128711899	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:128711899G>C	ENST00000265068.5	-	2	416	c.249C>G	c.(247-249)ttC>ttG	p.F83L	KIAA1257_ENST00000510149.1_Intron|KIAA1257_ENST00000511438.1_Missense_Mutation_p.F83L	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	83										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						TATTCACAGGGAAGGCCAGTG	0.547000													15	103					0	0	0.189662	0	0
NANP	140838	broad.mit.edu	37	20	25596690	25596690	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:25596690T>C	ENST00000304788.3	-	2	844	c.618A>G	c.(616-618)acA>acG	p.T206T		NM_152667.2	NP_689880.1	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	206					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity			endometrium(2)|lung(2)|prostate(1)	5						TGATCCAGACTGTTGCTTTCA	0.468000													5	37					0	0	0.184627	0	0
PEAR1	375033	broad.mit.edu	37	1	156874545	156874545	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:156874545C>T	ENST00000338302.3	+	4	332	c.107C>T	c.(106-108)aCt>aTt	p.T36I	PEAR1_ENST00000292357.7_Missense_Mutation_p.T36I			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	36	EMI.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGCAGCTTCACTACCACCACC	0.677000													16	86					0	0	0.146539	0	0
TSNAXIP1	55815	broad.mit.edu	37	16	67860156	67860156	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:67860156C>T	ENST00000388833.3	+	10	1461	c.1084C>T	c.(1084-1086)Ctg>Ttg	p.L362L	TSNAXIP1_ENST00000415766.3_Silent_p.L347L|TSNAXIP1_ENST00000561639.1_Silent_p.L416L	NM_018430.2	NP_060900.2	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein 1	362					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|soft_tissue(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		TTCGGGGCTGCTGCGGGAGAA	0.632000													5	14					0	0	0.184627	0	0
CACNA2D1	781	broad.mit.edu	37	7	81643766	81643766	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:81643766T>C	ENST00000356860.3	-	13	1511	c.1173A>G	c.(1171-1173)caA>caG	p.Q391Q	MIR1255B1_ENST00000454066.1_RNA|MIR1255B1_ENST00000439234.1_RNA|CACNA2D1_ENST00000356253.5_Silent_p.Q391Q|CACNA2D1_ENST00000464354.1_5'UTR	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	391	VWFA.					voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CATAATTGTGTTGACCAACTG	0.318000													6	23					0	0	0.038147	0	0
ASB4	51666	broad.mit.edu	37	7	95157271	95157271	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:95157271C>T	ENST00000325885.5	+	3	705	c.634C>T	c.(634-636)Ctg>Ttg	p.L212L	ASB4_ENST00000428113.1_Silent_p.L212L	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	212					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			GGAGACCCCCCTGGCCATCGC	0.622000											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	43					0	0	0.093190	0	0
ZNF695	57116	broad.mit.edu	37	1	247150501	247150501	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:247150501T>C	ENST00000339986.7	-	4	1463	c.1316A>G	c.(1315-1317)gAt>gGt	p.D439G	ZNF695_ENST00000498046.2_Intron|ZNF695_ENST00000487338.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	439					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GCCACATTCATCACATTTGTA	0.368000													3	80					0	0	0.115264	0	0
AFAP1	60312	broad.mit.edu	37	4	7870433	7870433	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:7870433C>T	ENST00000420658.1	-	3	413	c.141G>A	c.(139-141)aaG>aaA	p.K47K	AFAP1_ENST00000358461.2_Silent_p.K47K|AFAP1_ENST00000382543.3_Silent_p.K47K|AFAP1_ENST00000360265.4_Silent_p.K47K	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	47						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						GAGCATGGTCCTTCACATCAA	0.547000													3	16					0	0	0.115264	0	0
FCRL1	115350	broad.mit.edu	37	1	157773775	157773775	+	Missense_Mutation	SNP	G	G	A	rs149142723	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:157773775G>A	ENST00000358292.3	-	3	230	c.179C>T	c.(178-180)gCc>gTc	p.A60V	FCRL1_ENST00000368176.3_Missense_Mutation_p.A60V|FCRL1_ENST00000491942.1_Missense_Mutation_p.A60V|FCRL1_ENST00000489998.1_5'UTR	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	60	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGGGCCCAAGGCCCGGGTGTC	0.582000													20	79					0	0	0.204396	0	0
DNAH5	1767	broad.mit.edu	37	5	13794128	13794128	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:13794128T>C	ENST00000265104.4	-	48	8031	c.7927A>G	c.(7927-7929)Aca>Gca	p.T2643A		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2643	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGGCCATATGTTGTACCCATT	0.378000									Kartagener syndrome				4	50					0	0	0.184627	0	0
OR5T2	219464	broad.mit.edu	37	11	55999910	55999910	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:55999910A>G	ENST00000313264.4	-	1	827	c.752T>C	c.(751-753)cTg>cCg	p.L251P		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L251Q(1)		endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					CAGAACAATCAGGATAGTGAC	0.443000													6	125					0	0	0.217242	0	0
ROBO4	54538	broad.mit.edu	37	11	124765507	124765507	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:124765507T>C	ENST00000306534.3	-	6	1367	c.882A>G	c.(880-882)ggA>ggG	p.G294G	ROBO4_ENST00000533054.1_Silent_p.G149G	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	294	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCACGGAGCTCCCTGGCCTC	0.647000													12	43					0	0	0.119110	0	0
KANK2	25959	broad.mit.edu	37	19	11286646	11286646	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:11286646G>T	ENST00000432929.2	-	8	2164	c.1804C>A	c.(1804-1806)Ctc>Atc	p.L602I	KANK2_ENST00000586659.1_Missense_Mutation_p.L594I|KANK2_ENST00000589894.1_Missense_Mutation_p.L594I|KANK2_ENST00000589359.1_Missense_Mutation_p.L602I|KANK2_ENST00000355150.5_Missense_Mutation_p.L594I	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	594										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCTGAGATGAGGTCAGGGCTT	0.602000													3	23					0.00909568	0.00963072	0.150653	1	0
SATB2	23314	broad.mit.edu	37	2	200137209	200137209	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:200137209C>A	ENST00000443023.1	-	10	3215	c.1750G>T	c.(1750-1752)Gaa>Taa	p.E584*	SATB2_ENST00000260926.5_Nonsense_Mutation_p.E643*|SATB2_ENST00000417098.1_Nonsense_Mutation_p.E643*|SATB2_ENST00000457245.1_Nonsense_Mutation_p.E643*|SATB2_ENST00000428695.1_Nonsense_Mutation_p.E525*			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	643						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGATGGCTTCCTGGTCTGGG	0.532000													10	81					4.68919e-08	6.01029e-08	0.069234	1	0
HDGF	3068	broad.mit.edu	37	1	156714082	156714082	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:156714082C>A	ENST00000357325.5	-	4	676	c.362G>T	c.(361-363)gGt>gTt	p.G121V	HDGF_ENST00000368209.5_Missense_Mutation_p.G114V|HDGF_ENST00000416666.2_Missense_Mutation_p.G89V|HDGF_ENST00000537739.1_Missense_Mutation_p.G121V|HDGF_ENST00000368206.5_Missense_Mutation_p.G137V|HDGF_ENST00000465180.1_5'UTR	NM_004494.2	NP_004485.1	P51858	HDGF_HUMAN	hepatoma-derived growth factor	121	Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		ATCACCGTCACCCTCTGCAGC	0.577000													85	263					3.89424e-36	5.54026e-36	0.139131	1	0
LY6D	8581	broad.mit.edu	37	8	143867036	143867036	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:143867036G>T	ENST00000301263.4	-	2	195	c.120C>A	c.(118-120)gcC>gcA	p.A40A	LY6D_ENST00000518434.1_5'UTR|RP11-706C16.8_ENST00000510610.2_RNA	NM_003695.2	NP_003686.1	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D	40	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding			large_intestine(1)|lung(3)|prostate(1)	5	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					AGCGAGAGCTGGCCGGGCAGA	0.652000													7	16					1.76689e-08	2.29308e-08	0.058154	1	0
CRISP1	167	broad.mit.edu	37	6	49814333	49814333	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:49814333C>A	ENST00000335847.4	-	5	436	c.335G>T	c.(334-336)tGg>tTg	p.W112L	CRISP1_ENST00000505118.1_Missense_Mutation_p.W112L|CRISP1_ENST00000355791.2_Missense_Mutation_p.W112L|CRISP1_ENST00000329411.5_Missense_Mutation_p.W112L|CRISP1_ENST00000507853.1_Missense_Mutation_p.W112L|CRISP1_ENST00000536021.1_Missense_Mutation_p.W112L	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	112					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					TACACTTGACCATGATACAGG	0.393000													10	80					3.07112e-06	3.71767e-06	0.080935	1	0
GBA3	57733	broad.mit.edu	37	4	22749300	22749300	+	RNA	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:22749300C>G	ENST00000511446.1	+	0	671				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GTGTCTCTATCACTTTTTGCG	0.433000													25	146					0	0	0.083992	0	0
PELI1	57162	broad.mit.edu	37	2	64323337	64323337	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:64323337T>C	ENST00000358912.4	-	6	1054	c.612A>G	c.(610-612)ggA>ggG	p.G204G		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	204					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						CTCTCCATATTCCAGGCTTGG	0.438000													69	113					0	0	0.139131	0	0
PHACTR1	221692	broad.mit.edu	37	6	13160516	13160516	+	Splice_Site	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:13160516G>A	ENST00000379350.1	+	5	625	c.496_splice	c.e5+1	p.D166_splice	PHACTR1_ENST00000457702.2_Splice_Site_p.D21_splice|PHACTR1_ENST00000379345.2_Splice_Site_p.D21_splice|PHACTR1_ENST00000482982.1_3'UTR|PHACTR1_ENST00000332995.7_Splice_Site_p.D166_splice			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	166						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTATGATAAAGGTAAGGAGGA	0.428000													5	172					0	0	0.184627	0	0
TTN	7273	broad.mit.edu	37	2	179439236	179439236	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:179439236T>C	ENST00000589042.1	-	326	71847	c.71623A>G	c.(71623-71625)Act>Gct	p.T23875A	TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T15002A|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T21307A|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T14810A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.T22234A|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T14935A|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22234	Ig-like 120.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCTCACAGTCTGCCAGAGA	0.418000													16	138					0	0	0.160694	0	0
OR5T3	390154	broad.mit.edu	37	11	56019977	56019977	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:56019977C>A	ENST00000303059.3	+	1	302	c.302C>A	c.(301-303)gCt>gAt	p.A101D		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A101V(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TTCTTGGATGCTTGCTATTCT	0.378000													6	63					0.00198382	0.00219014	0.248553	1	0
SPAM1	6677	broad.mit.edu	37	7	123594355	123594355	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:123594355A>G	ENST00000340011.5	+	3	1088	c.731A>G	c.(730-732)aAa>aGa	p.K244R	SPAM1_ENST00000402183.2_Missense_Mutation_p.K244R|SPAM1_ENST00000439500.1_Missense_Mutation_p.K244R|SPAM1_ENST00000223028.7_Missense_Mutation_p.K244R|SPAM1_ENST00000460182.1_Missense_Mutation_p.K244R	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	244					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	GTAGAAATAAAAAGAAATGAT	0.398000													4	74					0	0	0.217242	0	0
TET2	54790	broad.mit.edu	37	4	106155397	106155397	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:106155397G>T	ENST00000513237.1	+	3	1158	c.361G>T	c.(361-363)Gaa>Taa	p.E121*	TET2_ENST00000545826.1_Nonsense_Mutation_p.E100*|TET2_ENST00000540549.1_Nonsense_Mutation_p.E100*|TET2_ENST00000380013.4_Nonsense_Mutation_p.E100*|TET2_ENST00000305737.2_Nonsense_Mutation_p.E100*|TET2_ENST00000394764.1_Nonsense_Mutation_p.E100*|TET2_ENST00000413648.2_Nonsense_Mutation_p.E100*			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	100					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CACAGTTAGTGAACCTTCTCT	0.428000			"""Mis N, F"""		MDS								25	100					2.48779e-11	3.35488e-11	0.108266	1	0
CEACAM20	125931	broad.mit.edu	37	19	45029235	45029235	+	RNA	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:45029235A>T	ENST00000454753.1	-	0	373							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				ATTGAGGGTGAGCTGGGCTGC	0.587000													22	196					0	0	0.264190	0	0
TREM1	54210	broad.mit.edu	37	6	41250157	41250157	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:41250157G>T	ENST00000591620.1	-	2	408	c.382C>A	c.(382-384)Cgc>Agc	p.R128S	TREM1_ENST00000244709.4_Missense_Mutation_p.R128S|TREM1_ENST00000334475.6_Missense_Mutation_p.R128S|TREM1_ENST00000589614.1_Missense_Mutation_p.R128S	NM_001242589.1	NP_001229518.1	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	128	Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			NS(1)|breast(2)|endometrium(2)|large_intestine(5)|lung(5)|skin(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	AAGCGGATGCGATCGAACAGC	0.562000													7	52					0.00307968	0.00338193	0.038147	1	0
NRXN1	9378	broad.mit.edu	37	2	50765733	50765733	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:50765733G>T	ENST00000404971.1	-	11	3260	c.1921C>A	c.(1921-1923)Cct>Act	p.P641T	NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000405472.3_Missense_Mutation_p.P593T|NRXN1_ENST00000401669.2_Missense_Mutation_p.P601T|NRXN1_ENST00000406316.2_Missense_Mutation_p.P601T|NRXN1_ENST00000402717.3_Missense_Mutation_p.P593T|NRXN1_ENST00000406859.3_Missense_Mutation_p.P601T	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	601	Laminin G-like 3.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTCTCACCAGGAGCAGTGTAG	0.483000													18	57					1.67942e-08	2.18641e-08	0.175082	1	0
SNAI2	6591	broad.mit.edu	37	8	49832983	49832983	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:49832983G>C	ENST00000396822.1	-	3	454	c.97C>G	c.(97-99)Ctc>Gtc	p.L33V	SNAI2_ENST00000020945.1_Missense_Mutation_p.L33V			O43623	SNAI2_HUMAN	snail family zinc finger 2	33					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)	18		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				CTCTCATAGAGATACGGGGAA	0.443000													14	82					0	0	0.132662	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455200	187455200	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:187455200C>A	ENST00000307161.5	-	2	897	c.696G>T	c.(694-696)caG>caT	p.Q232H	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	232					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCCTGAAGTCCTGTGGTTTCA	0.493000													7	85					1.06961e-07	1.35006e-07	0.038147	1	0
FAM45B	55855	broad.mit.edu	37	X	129629602	129629602	+	RNA	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:129629602G>T	ENST00000458525.1	-	0	1015				FAM45B_ENST00000592932.1_RNA																							TACCCGGCTGGCTCCATCAAA	0.428000													24	64					2.44723e-14	3.37718e-14	0.099896	1	0
DRD3	1814	broad.mit.edu	37	3	113849973	113849973	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:113849973A>G	ENST00000383673.2	-	6	1428	c.998T>C	c.(997-999)aTt>aCt	p.I333T	DRD3_ENST00000460779.1_Missense_Mutation_p.I333T|DRD3_ENST00000295881.7_Missense_Mutation_p.I300T|DRD3_ENST00000467632.1_Missense_Mutation_p.I333T	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	333					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	ACCAAGCACAATGGCCACCAT	0.493000													6	36					0	0	0.217242	0	0
RFC2	5982	broad.mit.edu	37	7	73661077	73661077	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:73661077T>C	ENST00000055077.3	-	5	409	c.349A>G	c.(349-351)Agg>Ggg	p.R117G	RFC2_ENST00000352131.3_Intron	NM_181471.1	NP_852136.1	P35250	RFC2_HUMAN	replication factor C (activator 1) 2, 40kDa	117					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)	8						ATTTTATTCCTCACAACGTCA	0.408000													7	28					0	0	0.248553	0	0
ADC	113451	broad.mit.edu	37	1	33567486	33567486	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:33567486C>A	ENST00000358680.3	+	8	1195	c.608C>A	c.(607-609)gCc>gAc	p.A203D	ADC_ENST00000398167.1_Intron|ADC_ENST00000373440.1_Missense_Mutation_p.A203D|ADC_ENST00000484656.1_Intron|ADC_ENST00000373441.1_Intron|ADC_ENST00000373443.3_Intron|ADC_ENST00000294517.6_Intron			Q96A70	ADC_HUMAN	arginine decarboxylase	0					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	catttcattgccgtgtagcgc	0.428000													4	48					0.00024832	0.00027936	0.150653	1	0
KIAA1919	91749	broad.mit.edu	37	6	111585053	111585053	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:111585053A>G	ENST00000368847.4	+	3	570	c.217A>G	c.(217-219)Acc>Gcc	p.T73A		NM_153369.2	NP_699200.2	Q5TF39	NAGT1_HUMAN	KIAA1919	73					carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			large_intestine(3)|lung(2)|ovary(4)|skin(3)	12		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		GTCGGCTACCACCGTTGGTCT	0.378000													3	29					0	0	0.115264	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159820152	159820152	+	RNA	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:159820152G>T	ENST00000497452.1	-	0	517																											CAGGGCGTTTGGAGTCCAATA	0.428000													8	55					2.62144e-13	3.55828e-13	0.047766	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113518398	113518398	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:113518398A>G	ENST00000284601.3	-	4	2817	c.2749T>C	c.(2749-2751)Tcc>Ccc	p.S917P		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	917					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGATGTTTGGAAAAAGGAGAG	0.398000													7	118					0	0	0.248553	0	0
MTMR6	9107	broad.mit.edu	37	13	25840012	25840012	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:25840012T>G	ENST00000381801.5	-	5	1297	c.536A>C	c.(535-537)aAg>aCg	p.K179T	MTMR6_ENST00000540661.1_Missense_Mutation_p.K179T	NM_004685.3	NP_004676.3	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	179	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GCTCCGGAACTTGGAACTACC	0.363000													10	112					0	0	0.069234	0	0
PCDH15	65217	broad.mit.edu	37	10	55943337	55943337	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:55943337C>T	ENST00000373965.2	-	14	1872	c.1478G>A	c.(1477-1479)gGt>gAt	p.G493D	PCDH15_ENST00000395446.1_Missense_Mutation_p.G486D|PCDH15_ENST00000437009.1_Missense_Mutation_p.G486D|PCDH15_ENST00000395445.1_Missense_Mutation_p.G493D|PCDH15_ENST00000414778.1_Missense_Mutation_p.G491D|PCDH15_ENST00000395430.1_Missense_Mutation_p.G486D|PCDH15_ENST00000409834.1_Missense_Mutation_p.G97D|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.G486D|PCDH15_ENST00000373957.3_Missense_Mutation_p.G464D|PCDH15_ENST00000373955.1_Missense_Mutation_p.G486D|PCDH15_ENST00000395438.1_Missense_Mutation_p.G486D|PCDH15_ENST00000361849.3_Missense_Mutation_p.G486D|PCDH15_ENST00000395433.1_Missense_Mutation_p.G464D|PCDH15_ENST00000395432.2_Missense_Mutation_p.G449D	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	486	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCTTGTACACCATCAAATGC	0.358000										HNSCC(58;0.16)			8	70					0	0	0.038147	0	0
FAM131A	131408	broad.mit.edu	37	3	184059582	184059582	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:184059582C>T	ENST00000340957.5	+	3	319	c.47C>T	c.(46-48)gCg>gTg	p.A16V	FAM131A_ENST00000453072.1_Missense_Mutation_p.A16V|FAM131A_ENST00000450976.1_Missense_Mutation_p.A16V|FAM131A_ENST00000383847.2_Missense_Mutation_p.A101V|EIF2B5_ENST00000444495.1_Intron|FAM131A_ENST00000418281.1_Intron|FAM131A_ENST00000310585.4_5'UTR	NM_001171093.1	NP_001164564.1	Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	0						extracellular region		p.A101V(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGATCGCTGCGCTGGCCAGG	0.557000													20	145					0	0	0.219247	0	0
MYH1	4619	broad.mit.edu	37	17	10402375	10402375	+	Silent	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:10402375T>A	ENST00000226207.5	-	29	3994	c.3900A>T	c.(3898-3900)acA>acT	p.T1300T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1300						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GTGAAACTAGTGTGTCCTTTT	0.393000													13	103					0	0	0.093190	0	0
POMGNT1	55624	broad.mit.edu	37	1	46657877	46657877	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:46657877A>G	ENST00000371992.1	-	17	2082	c.1432T>C	c.(1432-1434)Tgg>Cgg	p.W478R	POMGNT1_ENST00000371984.3_Missense_Mutation_p.W478R|POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000485714.1_5'UTR|POMGNT1_ENST00000371986.3_Missense_Mutation_p.W478R|POMGNT1_ENST00000535522.1_Missense_Mutation_p.W456R	NM_001243766.1	NP_001230695.1	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	478					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					ATCCGCATCCACATGTCCCAA	0.562000													12	66					0	0	0.080935	0	0
NEK10	152110	broad.mit.edu	37	3	27297818	27297818	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:27297818T>C	ENST00000429845.2	-	24	2421	c.2059A>G	c.(2059-2061)Acc>Gcc	p.T687A	NEK10_ENST00000357467.2_Missense_Mutation_p.T84A|NEK10_ENST00000341435.5_Missense_Mutation_p.T687A			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	687	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						ACCACAGAGGTGAGTTTACTG	0.343000													7	12					0	0	0.038147	0	0
ACAT2	39	broad.mit.edu	37	6	160199778	160199778	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:160199778G>C	ENST00000367048.4	+	9	2871	c.1111G>C	c.(1111-1113)Gag>Cag	p.E371Q	ACAT2_ENST00000472052.1_3'UTR|ACAT2_ENST00000541436.1_Missense_Mutation_p.E400Q|TCP1_ENST00000321394.7_3'UTR	NM_005891.2	NP_005882.2	Q9BWD1	THIC_HUMAN	acetyl-CoA acetyltransferase 2	371						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(1)	9		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ACACACACTGGAGAGAATGGG	0.502000													6	70					0	0	0.038147	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767647	77767647	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:77767647C>A	ENST00000521891.2	+	10	8938	c.8490C>A	c.(8488-8490)tcC>tcA	p.S2830S	ZFHX4_ENST00000455469.2_Silent_p.S2785S|ZFHX4_ENST00000050961.6_Silent_p.S2785S|ZFHX4_ENST00000518282.1_Silent_p.S2804S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2785						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S2814S(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGGAAGTTCCGGAGATGTGA	0.488000										HNSCC(33;0.089)			15	52					2.23348e-06	2.74381e-06	0.146539	1	0
TPO	7173	broad.mit.edu	37	2	1457533	1457533	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:1457533G>A	ENST00000345913.4	+	6	641	c.550G>A	c.(550-552)Ggc>Agc	p.G184S	TPO_ENST00000382201.3_Missense_Mutation_p.G184S|TPO_ENST00000382198.1_Missense_Mutation_p.G184S|TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Missense_Mutation_p.G184S|TPO_ENST00000346956.3_Missense_Mutation_p.G184S|TPO_ENST00000337415.3_Missense_Mutation_p.G184S|TPO_ENST00000329066.4_Missense_Mutation_p.G184S	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	184					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CTATGAGGACGGCTTCAGTCA	0.587000													4	16					0	0	0.184627	0	0
KRT15	3866	broad.mit.edu	37	17	39671752	39671752	+	Missense_Mutation	SNP	G	G	C	rs138894344		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:39671752G>C	ENST00000254043.3	-	6	4804	c.1219C>G	c.(1219-1221)Cgc>Ggc	p.R407G	KRT15_ENST00000393981.3_Missense_Mutation_p.R242G|KRT15_ENST00000393976.2_Missense_Mutation_p.R407G|KRT15_ENST00000393974.3_Missense_Mutation_p.R242G	NM_002275.3	NP_002266.2	P19012	K1C15_HUMAN	keratin 15	407	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		Breast(137;0.000286)				AGCAGGCTGCGGTAAGTAGCG	0.592000													7	29					0	0	0.038147	0	0
TCERG1L	256536	broad.mit.edu	37	10	132944790	132944790	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:132944790G>T	ENST00000368642.4	-	7	1253	c.1168C>A	c.(1168-1170)Cgc>Agc	p.R390S		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	390										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		TCCAGCTTGCGTTTGTGGGGC	0.498000													7	43					0.00307968	0.00338193	0.038147	1	0
AHNAK2	113146	broad.mit.edu	37	14	105409427	105409427	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:105409427G>A	ENST00000333244.5	-	7	12480	c.12361C>T	c.(12361-12363)Ctg>Ttg	p.L4121L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4121						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGTCGGCCAGGGACAGGTCC	0.587000													3	73					0	0	0.184627	0	0
KIF13B	23303	broad.mit.edu	37	8	28998003	28998003	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:28998003G>A	ENST00000524189.1	-	20	2504	c.2466C>T	c.(2464-2466)atC>atT	p.I822I	CTD-2647L4.1_ENST00000523661.1_RNA|CTD-2647L4.1_ENST00000517632.1_RNA	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	822					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TCTGGTTGATGATGGGAACAG	0.413000													9	59					0	0	0.058154	0	0
DMRTB1	63948	broad.mit.edu	37	1	53927166	53927166	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:53927166C>A	ENST00000371445.3	+	2	653	c.598C>A	c.(598-600)Ccg>Acg	p.P200T	DMRTB1_ENST00000463126.1_3'UTR	NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	200	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						GAACATCAACCCGGACCGTGC	0.662000													6	44					5.4927e-09	7.17344e-09	0.047766	1	0
COL14A1	7373	broad.mit.edu	37	8	121259925	121259925	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:121259925C>T	ENST00000297848.3	+	21	2823	c.2553C>T	c.(2551-2553)ccC>ccT	p.P851P	COL14A1_ENST00000247781.3_Silent_p.P756P|COL14A1_ENST00000309791.4_Silent_p.P851P|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	851	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CGTGGGACCCCCCATCTTCCC	0.453000													5	91					0	0	0.184627	0	0
LRP1B	53353	broad.mit.edu	37	2	141027875	141027875	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:141027875C>A	ENST00000389484.3	-	86	14154	c.13183G>T	c.(13183-13185)Gat>Tat	p.D4395Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4395	EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.D4395Y(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTAGCCATCACATAACTGA	0.398000										TSP Lung(27;0.18)			23	42					1.30998e-17	1.82604e-17	0.225048	1	0
MADD	8567	broad.mit.edu	37	11	47345285	47345285	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:47345285G>A	ENST00000342922.4	+	28	4621	c.4264G>A	c.(4264-4266)Gag>Aag	p.E1422K	MADD_ENST00000311027.5_Missense_Mutation_p.E1481K|MADD_ENST00000402192.2_Missense_Mutation_p.E1421K|MADD_ENST00000395336.3_Missense_Mutation_p.E1481K|MADD_ENST00000407859.3_Missense_Mutation_p.E1399K|MADD_ENST00000406482.1_Missense_Mutation_p.E1379K|MADD_ENST00000405573.2_Missense_Mutation_p.E291K|MADD_ENST00000402799.1_Missense_Mutation_p.E1379K|MADD_ENST00000395344.3_Missense_Mutation_p.E1375K|MADD_ENST00000349238.3_Missense_Mutation_p.E1442K	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1481					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CTGGTGGTACGAGAAGCTCAT	0.498000													6	61					0	0	0.217242	0	0
PRELP	5549	broad.mit.edu	37	1	203452736	203452736	+	Missense_Mutation	SNP	G	G	A	rs56086342		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:203452736G>A	ENST00000343110.2	+	2	551	c.424G>A	c.(424-426)Gac>Aac	p.D142N		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	142					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			CCGCAAGATAGACCAGAGGGT	0.572000													27	105					0	0	0.183431	0	0
BMP1	649	broad.mit.edu	37	8	22035126	22035126	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:22035126T>C	ENST00000354870.5	+	6	1043	c.777T>C	c.(775-777)aaT>aaC	p.N259N	BMP1_ENST00000306349.8_Intron|BMP1_ENST00000397816.3_Intron|BMP1_ENST00000306385.5_Intron|BMP1_ENST00000397814.3_Intron			P13497	BMP1_HUMAN	bone morphogenetic protein 1	0	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCTCTAGAAATGGTGCTTCCT	0.582000													9	202					0	0	0.047766	0	0
ADAM2	2515	broad.mit.edu	37	8	39678647	39678647	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:39678647G>A	ENST00000265708.4	-	6	490	c.387C>T	c.(385-387)ccC>ccT	p.P129P	ADAM2_ENST00000379853.2_Silent_p.P129P|ADAM2_ENST00000523181.1_5'UTR|ADAM2_ENST00000347580.4_Silent_p.P129P|ADAM2_ENST00000521880.1_Silent_p.P129P	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	129					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AAGACTCCAGGGGTTCTATTC	0.313000													3	46					0	0	0.150653	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994078	140994078	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:140994078G>C	ENST00000285879.4	+	4	1174	c.888G>C	c.(886-888)gaG>gaC	p.E296D	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	296							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GTACTTTTGAGGGTTTTCCCC	0.498000										HNSCC(15;0.026)			10	56					0	0	0.203993	0	0
GRIK2	2898	broad.mit.edu	37	6	102069929	102069929	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:102069929C>G	ENST00000369138.1	+	2	711	c.221C>G	c.(220-222)aCt>aGt	p.T74S	GRIK2_ENST00000369137.3_Missense_Mutation_p.T74S|GRIK2_ENST00000421544.1_Missense_Mutation_p.T74S|GRIK2_ENST00000413795.1_Missense_Mutation_p.T74S|GRIK2_ENST00000369134.4_Missense_Mutation_p.T25S|GRIK2_ENST00000358361.3_Missense_Mutation_p.T74S|GRIK2_ENST00000318991.6_Missense_Mutation_p.T74S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	74					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CTACCCAATACTACCCTTACC	0.358000													15	59					0	0	0.160694	0	0
SORCS1	114815	broad.mit.edu	37	10	108439018	108439018	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:108439018C>A	ENST00000263054.6	-	12	1743	c.1736G>T	c.(1735-1737)aGa>aTa	p.R579I	SORCS1_ENST00000344440.6_Missense_Mutation_p.R579I|SORCS1_ENST00000369698.1_Missense_Mutation_p.R114I	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	579						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCTTACCTGTCTCCAGGTGTT	0.413000													7	69					0.0477658	0.0495615	0.047766	1	0
FLG	2312	broad.mit.edu	37	1	152276508	152276508	+	Silent	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:152276508T>G	ENST00000368799.1	-	3	10889	c.10854A>C	c.(10852-10854)gcA>gcC	p.A3618A	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3618	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTTGATCTTGCCTGTTCAT	0.557000									Ichthyosis				12	329					0	0	0.160694	0	0
PLCB3	5331	broad.mit.edu	37	11	64029061	64029061	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:64029061A>T	ENST00000540288.1	+	16	1940	c.1837A>T	c.(1837-1839)Aaa>Taa	p.K613*	PLCB3_ENST00000325234.5_Nonsense_Mutation_p.K546*|PLCB3_ENST00000279230.6_Nonsense_Mutation_p.K613*	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	613	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						AGAGAGGAACAAATGCTTCGA	0.577000													7	25					0	0	0.248553	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110394800	110394800	+	Splice_Site	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:110394800C>T	ENST00000378402.5	+	4	521	c.417_splice	c.e4+1	p.N139_splice		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	139					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTACCTTCAACGTATGTAGGA	0.393000										HNSCC(38;0.096)			17	94					0	0	0.146539	0	0
SNX29	92017	broad.mit.edu	37	16	12371874	12371874	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:12371874A>G	ENST00000566228.1	+	15	1832	c.1763A>G	c.(1762-1764)tAc>tGc	p.Y588C	SNX29_ENST00000323433.4_Missense_Mutation_p.Y203C|SNX29_ENST00000306030.3_Missense_Mutation_p.Y203C	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	203					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						GCAAGCTCCTACGAAAGAAAG	0.478000													4	67					0	0	0.150653	0	0
GLDN	342035	broad.mit.edu	37	15	51696918	51696918	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:51696918T>C	ENST00000335449.6	+	10	1679	c.1623T>C	c.(1621-1623)ccT>ccC	p.P541P	GLDN_ENST00000396399.2_Silent_p.P417P	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	541	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		TGCTTTATCCTGTGCAGTTTT	0.423000													4	96					0	0	0.150653	0	0
SYPL2	284612	broad.mit.edu	37	1	110018304	110018304	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:110018304C>G	ENST00000369872.3	+	3	447	c.231C>G	c.(229-231)atC>atG	p.I77M	SYPL2_ENST00000475497.1_3'UTR|SYPL2_ENST00000401021.3_Missense_Mutation_p.I77M	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	77	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GCTCCATCATCGTTGCATTTG	0.537000													6	58					0	0	0.248553	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013388	75013388	+	Silent	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:75013388T>G	ENST00000379727.3	-	6	1371	c.1173A>C	c.(1171-1173)acA>acC	p.T391T	CYP1A1_ENST00000567032.1_Silent_p.T391T|CYP1A1_ENST00000564596.1_Silent_p.T130T|CYP1A1_ENST00000395048.2_Silent_p.T391T|CYP1A1_ENST00000395049.4_Intron			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	391					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	TTGTGTCTCTTGTTGTGCTAG	0.502000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				3	50					0	0	0.115264	0	0
LMX1A	4009	broad.mit.edu	37	1	165218775	165218775	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:165218775G>T	ENST00000342310.3	-	4	748	c.366C>A	c.(364-366)tgC>tgA	p.C122*	LMX1A_ENST00000294816.2_Nonsense_Mutation_p.C122*|LMX1A_ENST00000367893.4_Nonsense_Mutation_p.C122*	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	122	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CGCAGACACAGCAGCAGAAGC	0.552000													15	42					0.0332995	0.0346382	0.160694	1	0
STAG1	10274	broad.mit.edu	37	3	136068096	136068096	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:136068096C>G	ENST00000383202.2	-	29	3431	c.3175G>C	c.(3175-3177)Gat>Cat	p.D1059H	STAG1_ENST00000236698.5_Missense_Mutation_p.D1059H|STAG1_ENST00000434713.2_Missense_Mutation_p.D799H|STAG1_ENST00000536929.1_Missense_Mutation_p.D643H	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1059					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GACATTCTATCATCTTCACCC	0.428000													9	29					0	0	0.093190	0	0
TTBK1	84630	broad.mit.edu	37	6	43237441	43237441	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:43237441G>C	ENST00000304139.5	+	13	2056	c.1894G>C	c.(1894-1896)Gcg>Ccg	p.A632P	TTBK1_ENST00000259750.4_Intron			Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	1245						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GCGACGACTGGCGTCCTCCGT	0.647000													33	28					0	0	0.139131	0	0
TXNDC11	51061	broad.mit.edu	37	16	11829940	11829940	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:11829940G>T	ENST00000356957.3	-	2	511	c.404C>A	c.(403-405)cCt>cAt	p.P135H	TXNDC11_ENST00000283033.5_Missense_Mutation_p.P135H			Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	135	Thioredoxin 1.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						TCCACACCAAGGGGCATAGAA	0.507000													7	166					0.00448238	0.00488344	0.047766	1	0
RUNX1T1	862	broad.mit.edu	37	8	92982976	92982976	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:92982976C>A	ENST00000523629.1	-	11	1903	c.1449G>T	c.(1447-1449)agG>agT	p.R483S	RUNX1T1_ENST00000520724.1_Missense_Mutation_p.R446S|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.R456S|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.R494S|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.R456S|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.R446S|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.R483S|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.R446S	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	483					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CCATCTTGGCCCTCTCTGTTG	0.622000													10	19					0.0135373	0.0142607	0.093190	1	0
HYAL4	23553	broad.mit.edu	37	7	123516914	123516914	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:123516914A>G	ENST00000223026.4	+	5	1789	c.1151A>G	c.(1150-1152)aAt>aGt	p.N384S	HYAL4_ENST00000476325.1_Missense_Mutation_p.N384S	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	384					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						TGCAGGAACAATGGCAGGTGC	0.502000													8	32					0	0	0.058154	0	0
CEP350	9857	broad.mit.edu	37	1	179983551	179983551	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:179983551A>G	ENST00000367607.3	+	10	2381	c.1963A>G	c.(1963-1965)Agg>Ggg	p.R655G		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	655						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						ATCAGCAACTAGGCGACTACA	0.413000													13	32					0	0	0.132662	0	0
HHLA3	11147	broad.mit.edu	37	1	70820791	70820791	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:70820791G>T	ENST00000359875.5	+	1	297	c.157G>T	c.(157-159)Gta>Tta	p.V53L	HHLA3_ENST00000531950.1_Missense_Mutation_p.V53L|HHLA3_ENST00000432224.1_Missense_Mutation_p.V53L|HHLA3_ENST00000361764.4_Splice_Site|HHLA3_ENST00000486110.1_3'UTR|HHLA3_ENST00000370940.5_Missense_Mutation_p.V53L	NM_001036645.1	NP_001031722.1	Q9XRX5	HHLA3_HUMAN	HERV-H LTR-associating 3	53							protein binding			large_intestine(3)|lung(1)	4						acttcgtgccgtatgtacgaa	0.493000													5	21					4.096e-09	5.36628e-09	0.217242	1	0
AOC3	8639	broad.mit.edu	37	17	41003593	41003593	+	Missense_Mutation	SNP	G	G	T	rs402680		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:41003593G>T	ENST00000308423.2	+	1	393	c.233G>T	c.(232-234)cGg>cTg	p.R78L		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	78			R -> Q (in dbSNP:rs402680).		amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CTGACCCAGCGGCTGGGGCCA	0.657000													7	87					2.74318e-10	3.66347e-10	0.058154	1	0
KCNT2	343450	broad.mit.edu	37	1	196227513	196227513	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:196227513G>A	ENST00000367433.5	-	25	3051	c.2950C>T	c.(2950-2952)Ccc>Tcc	p.P984S	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.P1008S|KCNT2_ENST00000367431.4_Missense_Mutation_p.P942S|KCNT2_ENST00000451324.2_3'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1008						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CGCAGCAAGGGATGGTCCGAC	0.507000													12	45					0	0	0.093190	0	0
ADD2	119	broad.mit.edu	37	2	70900436	70900436	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:70900436T>C	ENST00000355733.3	-	15	2208	c.1764A>G	c.(1762-1764)ccA>ccG	p.P588P	ADD2_ENST00000407644.2_Intron|ADD2_ENST00000264436.3_Intron	NM_017488.3	NP_059522.1	P35612	ADDB_HUMAN	adducin 2 (beta)	590					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						GACCAGAGCCTGGCTCTCGTT	0.542000													23	67					0	0	0.091800	0	0
SPG11	80208	broad.mit.edu	37	15	44862813	44862813	+	Silent	SNP	C	C	T	rs150121550	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:44862813C>T	ENST00000261866.7	-	34	6403	c.6387G>A	c.(6385-6387)acG>acA	p.T2129T	SPG11_ENST00000535302.2_Silent_p.T2016T|SPG11_ENST00000427534.2_Silent_p.T2129T	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	2129					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCATGTGGCACGTCAGGGTGA	0.582000													3	13					0	0	0.115264	0	0
ZNF184	7738	broad.mit.edu	37	6	27419946	27419946	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:27419946G>A	ENST00000211936.6	-	6	1676	c.1392C>T	c.(1390-1392)caC>caT	p.H464H	ZNF184_ENST00000377419.1_Silent_p.H464H	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GAATTTTCAGGTGTTGAGCAA	0.408000													6	55					0	0	0.217242	0	0
ELMO1	9844	broad.mit.edu	37	7	36934500	36934500	+	Silent	SNP	G	G	T	rs140840691		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:36934500G>T	ENST00000310758.4	-	17	2207	c.1560C>A	c.(1558-1560)tcC>tcA	p.S520S	ELMO1_ENST00000396045.3_Silent_p.S40S|ELMO1_ENST00000448602.1_Silent_p.S520S|ELMO1_ENST00000341056.3_Silent_p.S222S|ELMO1_ENST00000442504.1_Silent_p.S520S|ELMO1_ENST00000396040.2_Silent_p.S40S	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	520					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding	p.S520S(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TCATCCTCTCGGACTGGCGGA	0.463000													17	39					3.41278e-10	4.54306e-10	0.160694	1	0
GLDN	342035	broad.mit.edu	37	15	51693895	51693895	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:51693895A>G	ENST00000335449.6	+	9	1189	c.1133A>G	c.(1132-1134)aAc>aGc	p.N378S	GLDN_ENST00000396399.2_Missense_Mutation_p.N254S	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	378	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GTTGTTTACAACAACTCTCTC	0.493000											OREG0023125	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	51					0	0	0.184627	0	0
CACNA1C	775	broad.mit.edu	37	12	2721083	2721083	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:2721083C>G	ENST00000399655.1	+	29	3997	c.3732C>G	c.(3730-3732)agC>agG	p.S1244R	CACNA1C_ENST00000480911.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399637.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S1269R|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S1264R|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S1244R|CACNA1C_ENST00000347598.4_Missense_Mutation_p.S1264R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1264				L -> P (in Ref. 16; AAA74590).	axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACGGCCAGAGCTGCCTGTTCA	0.572000													4	146					0	0	0.150653	0	0
DRP2	1821	broad.mit.edu	37	X	100491011	100491011	+	Splice_Site	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:100491011C>A	ENST00000395209.3	+	4	807	c.281_splice	c.e4+1	p.R94_splice	DRP2_ENST00000402866.1_Splice_Site_p.R94_splice|DRP2_ENST00000541709.1_Splice_Site_p.R16_splice|DRP2_ENST00000538510.1_Splice_Site_p.R94_splice	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	94					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding	p.?(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						TCACAACCTCCGGTAAGAAAC	0.512000													21	45					2.89027e-11	3.88497e-11	0.249174	1	0
PCDHB17P	54661	broad.mit.edu	37	5	140537246	140537246	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:140537246C>A	ENST00000539533.1	+	1	1670	c.1670C>A	c.(1669-1671)aCg>aAg	p.T557K																								TGGACGCCAACGACAACTCGC	0.706000													7	32					1.12685e-05	1.3329e-05	0.047766	1	0
AKNAD1	254268	broad.mit.edu	37	1	109385769	109385769	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:109385769A>G	ENST00000370001.3	-	6	1634	c.1366T>C	c.(1366-1368)Ttt>Ctt	p.F456L	AKNAD1_ENST00000369994.1_Missense_Mutation_p.F456L|AKNAD1_ENST00000369995.3_Missense_Mutation_p.F456L|AKNAD1_ENST00000357393.4_Missense_Mutation_p.F163L	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	456										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TCTGGATCAAAGTCACCAACG	0.483000													24	177					0	0	0.091800	0	0
OR12D2	26529	broad.mit.edu	37	6	29365302	29365302	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:29365302A>C	ENST00000383555.2	+	1	887	c.826A>C	c.(826-828)Atg>Ctg	p.M276L	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TGTTGCCATCATGTACACTGT	0.453000													6	181					0	0	0.038147	0	0
C10orf2	56652	broad.mit.edu	37	10	102753132	102753132	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:102753132G>C	ENST00000311916.2	+	5	2105	c.1920G>C	c.(1918-1920)aaG>aaC	p.K640N	C10orf2_ENST00000370228.1_3'UTR|C10orf2_ENST00000473656.1_3'UTR	NM_001163813.1|NM_021830.4	NP_001157285.1|NP_068602.2	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	640					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GGCTCAAGAAGATCAAGGATG	0.527000													15	123					0	0	0.160694	0	0
GRM1	2911	broad.mit.edu	37	6	146720539	146720539	+	Silent	SNP	G	G	A	rs114187147	byFrequency	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:146720539G>A	ENST00000392299.2	+	8	2834	c.2364G>A	c.(2362-2364)gcG>gcA	p.A788A	GRM1_ENST00000507907.1_Silent_p.A788A|GRM1_ENST00000355289.4_Silent_p.A788A|GRM1_ENST00000282753.1_Silent_p.A788A|GRM1_ENST00000361719.2_Silent_p.A788A|GRM1_ENST00000492807.2_Silent_p.A788A			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	788					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AATATATCGCGTTCACCATGT	0.488000													10	110					0	0	0.093190	0	0
BCAN	63827	broad.mit.edu	37	1	156622659	156622659	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:156622659T>C	ENST00000329117.4	+	8	2253	c.1917T>C	c.(1915-1917)ggT>ggC	p.G639G	BCAN_ENST00000361588.5_Silent_p.G639G|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	639					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCAGCCGAGGTGGAGTGGCCG	0.612000													11	79					0	0	0.119110	0	0
CEP70	80321	broad.mit.edu	37	3	138219396	138219396	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:138219396G>A	ENST00000264982.3	-	15	1648	c.1382C>T	c.(1381-1383)cCa>cTa	p.P461L	CEP70_ENST00000542237.1_Missense_Mutation_p.P441L|CEP70_ENST00000489254.1_Missense_Mutation_p.P309L|CEP70_ENST00000481834.1_Missense_Mutation_p.P461L|CEP70_ENST00000484888.1_Missense_Mutation_p.P461L	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	461					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						TTGAAAGTGTGGCATATTGCT	0.313000													31	184					0	0	0.163468	0	0
BPIFB3	359710	broad.mit.edu	37	20	31656612	31656612	+	Missense_Mutation	SNP	C	C	G	rs113939875		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:31656612C>G	ENST00000375494.3	+	10	982	c.982C>G	c.(982-984)Ctg>Gtg	p.L328V		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	328					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										TCTCCAGGCCCTGGGGAAGCT	0.577000													8	90					0	0	0.047766	0	0
SCN7A	6332	broad.mit.edu	37	2	167262949	167262949	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:167262949A>T	ENST00000409855.1	-	25	4316	c.4190T>A	c.(4189-4191)tTt>tAt	p.F1397Y		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1397					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ATACATTCCAAATACGGCATA	0.358000													12	125					0	0	0.093190	0	0
FAM198B	51313	broad.mit.edu	37	4	159052016	159052016	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:159052016A>T	ENST00000296530.8	-	4	1895	c.1274T>A	c.(1273-1275)tTg>tAg	p.L425*	FAM198B_ENST00000585682.1_Nonsense_Mutation_p.L425*|FAM198B_ENST00000393807.5_Nonsense_Mutation_p.L433*|FAM198B_ENST00000589306.1_5'UTR	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	425						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						TATAAAAACCAAATGCCTTGG	0.398000													11	39					0	0	0.093190	0	0
CLINT1	9685	broad.mit.edu	37	5	157232889	157232889	+	Silent	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:157232889A>T	ENST00000523094.1	-	7	1078	c.873T>A	c.(871-873)ccT>ccA	p.P291P	CLINT1_ENST00000523908.1_Silent_p.P309P|CLINT1_ENST00000530742.1_Silent_p.P291P|CLINT1_ENST00000411809.2_Silent_p.P309P|CLINT1_ENST00000296951.5_Silent_p.P291P	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	309					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGAAGACTGAGGTGTGTGGG	0.438000													13	30					0	0	0.146539	0	0
CNKSR1	10256	broad.mit.edu	37	1	26507069	26507069	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:26507069A>T	ENST00000361530.6	+	2	323	c.178A>T	c.(178-180)Atc>Ttc	p.I60F	CNKSR1_ENST00000374253.5_Missense_Mutation_p.I60F|CNKSR1_ENST00000480348.2_3'UTR|CNKSR1_ENST00000531191.1_5'UTR			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	60	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGAGCTCATCCTGGGCGG	0.647000													5	49					0	0	0.217242	0	0
TLK1	9874	broad.mit.edu	37	2	171906414	171906414	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:171906414C>A	ENST00000442919.2	-	10	1361	c.746G>T	c.(745-747)cGa>cTa	p.R249L	TLK1_ENST00000434911.2_Missense_Mutation_p.R201L|TLK1_ENST00000431350.2_Missense_Mutation_p.R297L|TLK1_ENST00000521943.1_Missense_Mutation_p.R249L|TLK1_ENST00000360843.3_Missense_Mutation_p.R318L	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	297					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						GAGGCGTAATCGATCTTGCAT	0.363000													11	60					6.40141e-05	7.36162e-05	0.080935	1	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338163	13338163	+	RNA	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:13338163G>T	ENST00000602906.1	+	0	181																				kidney(3)|lung(1)	4						CTTTCAGGCAGAAATTGCCCA	0.433000													8	55					2.17888e-05	2.5554e-05	0.058154	1	0
EXOC5	10640	broad.mit.edu	37	14	57689125	57689125	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:57689125G>C	ENST00000413566.2	-	13	1665	c.1306C>G	c.(1306-1308)Cct>Gct	p.P436A	EXOC5_ENST00000340918.7_Missense_Mutation_p.P371A	NM_006544.3	NP_006535.1	O00471	EXOC5_HUMAN	exocyst complex component 5	436					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				breast(3)|endometrium(1)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	22						AAGTCAGAAGGATCAGAGAGC	0.318000													4	131					0	0	0.184627	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128848784	128848784	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:128848784T>A	ENST00000310343.9	-	18	1960	c.1961A>T	c.(1960-1962)aAg>aTg	p.K654M	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.K580M|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.K305M|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.K305M	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	654					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CACAGGAGACTTTTTCATCTT	0.393000													6	48					0	0	0.217242	0	0
SHROOM4	57477	broad.mit.edu	37	X	50378521	50378521	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:50378521G>T	ENST00000376020.2	-	4	577	c.552C>A	c.(550-552)aaC>aaA	p.N184K	SHROOM4_ENST00000289292.7_Missense_Mutation_p.N184K|SHROOM4_ENST00000460112.3_Missense_Mutation_p.N68K	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	184					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					AGTCACGCTGGTTAGGGTACA	0.552000													3	8					2.56e-06	3.10804e-06	0.150653	1	0
SOBP	55084	broad.mit.edu	37	6	107954957	107954957	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:107954957G>A	ENST00000317357.5	+	6	1568	c.909G>A	c.(907-909)ccG>ccA	p.P303P		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	303							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GGAATATCCCGCTAACAGATG	0.607000													5	56					0	0	0.184627	0	0
RELN	5649	broad.mit.edu	37	7	103180650	103180650	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:103180650G>T	ENST00000424685.2	-	44	7083	c.6924C>A	c.(6922-6924)atC>atA	p.I2308I	RELN_ENST00000428762.1_Silent_p.I2308I|RELN_ENST00000343529.5_Silent_p.I2308I			P78509	RELN_HUMAN	reelin	2308					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGACCTGATCGATAACCCAGG	0.488000													4	44					1.23904e-05	1.45728e-05	0.184627	1	0
PGBD2	267002	broad.mit.edu	37	1	249211295	249211295	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:249211295A>G	ENST00000539153.1	+	4	758	c.503A>G	c.(502-504)aAt>aGt	p.N168S	PGBD2_ENST00000329291.5_Missense_Mutation_p.N171S|PGBD2_ENST00000355360.4_Intron|PGBD2_ENST00000462488.1_Intron			Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	171										NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AAAAATGTCAATTTGAGTCTT	0.388000													65	119					0	0	0.139131	0	0
RIMS2	9699	broad.mit.edu	37	8	105105708	105105708	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:105105708G>C	ENST00000436393.2	+	21	2972	c.2731G>C	c.(2731-2733)Gga>Cga	p.G911R	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	366	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTATCGATCAGGATGGGATCC	0.383000										HNSCC(12;0.0054)			35	102					0	0	0.214465	0	0
BAAT	570	broad.mit.edu	37	9	104133326	104133326	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:104133326C>T	ENST00000259407.2	-	2	469	c.361G>A	c.(361-363)Gct>Act	p.A121T	BAAT_ENST00000395051.3_Missense_Mutation_p.A121T	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	121					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	GCCTTTGGAGCACTGGCAACT	0.453000													14	89					0	0	0.105934	0	0
VPS18	57617	broad.mit.edu	37	15	41188205	41188205	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:41188205C>T	ENST00000220509.5	+	2	500	c.161C>T	c.(160-162)tCc>tTc	p.S54F	VPS18_ENST00000558474.1_Missense_Mutation_p.S54F	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	54					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TTCACCCCTTCCGAGCGCATT	0.512000													4	114					0	0	0.184627	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	104					0	0	0.150653	0	0
KRT28	162605	broad.mit.edu	37	17	38956072	38956072	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:38956072T>C	ENST00000306658.7	-	1	139	c.74A>G	c.(73-75)aAt>aGt	p.N25S		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	25	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				TGCACCTCCATTGAGGGGTCT	0.512000													5	70					0	0	0.047766	0	0
ATP9A	10079	broad.mit.edu	37	20	50230268	50230268	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:50230268G>A	ENST00000338821.5	-	23	2783	c.2519C>T	c.(2518-2520)gCc>gTc	p.A840V	ATP9A_ENST00000402822.1_Missense_Mutation_p.A719V|ATP9A_ENST00000311637.5_Missense_Mutation_p.A704V	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	840					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GCTGAGGGCGGCTGACCGCTT	0.552000													8	72					0	0	0.047766	0	0
LINC01410	103352539	broad.mit.edu	37	9	66457322	66457322	+	RNA	SNP	G	G	C	rs11262292		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:66457322G>C	ENST00000424345.1	+	0	34																											tggagcgacagcgacagagcc	0.632000													3	16					0	0	0.150653	0	0
SEMG2	6407	broad.mit.edu	37	20	43851066	43851066	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:43851066A>G	ENST00000372769.3	+	2	883	c.793A>G	c.(793-795)Aag>Gag	p.K265E		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	265	4 X 60 AA tandem repeats, type I.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				AGTATATAACAAGAATCAACA	0.403000													25	102					0	0	0.108266	0	0
NRIP1	8204	broad.mit.edu	37	21	16340473	16340473	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:16340473T>A	ENST00000400202.1	-	3	753	c.41A>T	c.(40-42)gAt>gTt	p.D14V	NRIP1_ENST00000400199.1_Missense_Mutation_p.D14V|NRIP1_ENST00000318948.4_Missense_Mutation_p.D14V			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	14					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity	p.D14A(1)		cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AACAATAGAATCCTGGTGCAC	0.423000													6	32					0	0	0.047766	0	0
PSG9	5678	broad.mit.edu	37	19	43762248	43762248	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:43762248C>T	ENST00000244293.7	-	4	1136	c.1070G>A	c.(1069-1071)gGc>gAc	p.G357D	PSG9_ENST00000291752.5_Intron|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000443718.3_Intron|PSG9_ENST00000593948.1_Intron|PSG9_ENST00000270077.3_Intron|PSG9_ENST00000596730.1_Missense_Mutation_p.G264D			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	0	Ig-like C2-type 3.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				TTTGCTTGTGCCCATGGGACA	0.453000													5	55					0	0	0.184627	0	0
PCIF1	63935	broad.mit.edu	37	20	44567887	44567887	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:44567887G>T	ENST00000372409.3	+	4	522	c.158G>T	c.(157-159)tGg>tTg	p.W53L		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	53	WW.					nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						GAGAAGTGCTGGAGCCGGAGG	0.622000													3	11					0.00909568	0.00963072	0.150653	1	0
ANKRD12	23253	broad.mit.edu	37	18	9256880	9256880	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:9256880C>T	ENST00000383440.2	+	8	3803	c.3546C>T	c.(3544-3546)tcC>tcT	p.S1182S	ANKRD12_ENST00000400020.3_Silent_p.S1182S|ANKRD12_ENST00000262126.3_Silent_p.S1205S	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1205						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						GATCTGTATCCATGATTTCTG	0.413000													28	101					0	0	0.108266	0	0
TOX2	84969	broad.mit.edu	37	20	42694514	42694514	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:42694514C>G	ENST00000358131.5	+	6	1277	c.1069C>G	c.(1069-1071)Cgg>Ggg	p.R357G	TOX2_ENST00000341197.3_Missense_Mutation_p.R375G|TOX2_ENST00000435864.2_Missense_Mutation_p.R253G|TOX2_ENST00000423191.1_Missense_Mutation_p.R333G|TOX2_ENST00000372999.1_Missense_Mutation_p.R333G	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CAGCCTCGCCCGGACGCTGGG	0.701000													12	19					0	0	0.160694	0	0
CDH13	1012	broad.mit.edu	37	16	83378607	83378607	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:83378607C>A	ENST00000566620.1	+	6	1067	c.777C>A	c.(775-777)ccC>ccA	p.P259P	CDH13_ENST00000569454.1_3'UTR|CDH13_ENST00000268613.10_Silent_p.P306P|CDH13_ENST00000428848.3_Silent_p.P220P	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	259	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		AAGGGTCACCCACAGGTATGT	0.507000													8	73					0.00448238	0.00488344	0.047766	1	0
C1orf173	127254	broad.mit.edu	37	1	75038451	75038451	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:75038451G>T	ENST00000326665.5	-	14	3161	c.2943C>A	c.(2941-2943)gcC>gcA	p.A981A	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	981	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCTCTCTTTGGCTGGTTCCT	0.542000													9	117					0.000274275	0.000307723	0.047766	1	0
NNT	23530	broad.mit.edu	37	5	43613236	43613236	+	Silent	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:43613236C>G	ENST00000264663.5	+	3	599	c.378C>G	c.(376-378)gtC>gtG	p.V126V	NNT_ENST00000344920.4_Silent_p.V126V|NNT_ENST00000512996.2_5'UTR	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	126					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	ATTTGGTGGTCAAAGTAATTA	0.413000													13	55					0	0	0.093190	0	0
PIGO	84720	broad.mit.edu	37	9	35090143	35090143	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:35090143G>A	ENST00000378617.3	-	9	3383	c.2989C>T	c.(2989-2991)Cgg>Tgg	p.R997W	PIGO_ENST00000361778.2_Missense_Mutation_p.R580W|PIGO_ENST00000341666.3_Missense_Mutation_p.R997W|PIGO_ENST00000298004.5_Missense_Mutation_p.R580W	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	997					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCCCGGAGCCGCATCTCCATC	0.577000													3	54					0	0	0.150653	0	0
TRPV2	51393	broad.mit.edu	37	17	16335351	16335351	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:16335351C>T	ENST00000338560.7	+	12	2125	c.1726C>T	c.(1726-1728)Cag>Tag	p.Q576*	TRPV2_ENST00000583241.1_3'UTR|TRPV2_ENST00000577397.1_Nonsense_Mutation_p.Q146*	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	576					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AGAGTCAGTGCAGCCCATGGA	0.622000													7	37					0	0	0.047766	0	0
FAM45B	55855	broad.mit.edu	37	X	129629298	129629298	+	RNA	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:129629298C>A	ENST00000458525.1	-	0	1015				FAM45B_ENST00000592932.1_RNA																							AAACAAACTTCTCCATCCCTT	0.393000													28	56					1.45844e-13	1.99271e-13	0.173368	1	0
RLF	6018	broad.mit.edu	37	1	40703619	40703619	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:40703619C>T	ENST00000372771.4	+	8	3272	c.3245C>T	c.(3244-3246)tCa>tTa	p.S1082L		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1082					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GGATCTTTCTCAGGGTCATTG	0.408000													9	43					0	0	0.058154	0	0
COL11A1	1301	broad.mit.edu	37	1	103487271	103487271	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:103487271C>A	ENST00000358392.2	-	9	1653	c.1336G>T	c.(1336-1338)Gtt>Ttt	p.V446F	COL11A1_ENST00000512756.1_Missense_Mutation_p.V318F|COL11A1_ENST00000370096.3_Missense_Mutation_p.V434F|COL11A1_ENST00000353414.4_Missense_Mutation_p.V395F	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	434	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACAGGCTCAACCACTGCTGGT	0.363000													7	23					0.000157383	0.000178511	0.038147	1	0
SCN1A	6323	broad.mit.edu	37	2	166897784	166897784	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:166897784G>T	ENST00000423058.2	-	13	2389	c.2372C>A	c.(2371-2373)cCa>cAa	p.P791Q	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.P763Q|SCN1A_ENST00000375405.3_Missense_Mutation_p.P780Q|SCN1A_ENST00000303395.4_Missense_Mutation_p.P791Q|AC010127.3_ENST00000595268.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	791						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTCCGTCATTGGATAGTGCTC	0.388000													4	35					0.000602214	0.000670206	0.184627	1	0
FREM1	158326	broad.mit.edu	37	9	14737453	14737453	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:14737453G>T	ENST00000380881.4	-	38	7299	c.6484C>A	c.(6484-6486)Caa>Aaa	p.Q2162K	FREM1_ENST00000422223.2_Missense_Mutation_p.Q2161K|FREM1_ENST00000380880.3_Missense_Mutation_p.Q2161K|FREM1_ENST00000380894.1_Missense_Mutation_p.Q697K			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	2161	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TCTTTTGTTTGCCATTTCCCT	0.478000													5	29					0.000602214	0.000670206	0.184627	1	0
PHF20	51230	broad.mit.edu	37	20	34459638	34459638	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:34459638A>T	ENST00000374012.3	+	9	1298	c.1169A>T	c.(1168-1170)gAt>gTt	p.D390V	PHF20_ENST00000439301.1_3'UTR|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					TCCTTTGGGGATGGATCCGGG	0.473000													31	121					0	0	0.246493	0	0
MSH6	2956	broad.mit.edu	37	2	48030811	48030811	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:48030811C>T	ENST00000234420.4	+	5	3577	c.3425C>T	c.(3424-3426)aCg>aTg	p.T1142M	FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Missense_Mutation_p.T1012M|MSH6_ENST00000538136.1_Missense_Mutation_p.T840M	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	1142					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGCAAGTCTACGCTTATGAGA	0.383000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				27	164					0	0	0.134883	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60036549	60036549	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:60036549G>T	ENST00000586569.1	+	9	1437	c.1399G>T	c.(1399-1401)Gga>Tga	p.G467*	TNFRSF11A_ENST00000269485.7_Intron	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	467					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				CCCAAAACGTGGACCCTTGCC	0.662000													5	60					3.59834e-05	4.18458e-05	0.217242	1	0
NLRX1	79671	broad.mit.edu	37	11	119054062	119054062	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:119054062C>A	ENST00000409109.1	+	10	3429	c.2842C>A	c.(2842-2844)Ctt>Att	p.L948I	NLRX1_ENST00000409265.4_Intron|NLRX1_ENST00000409991.1_Missense_Mutation_p.L948I|NLRX1_ENST00000292199.2_Missense_Mutation_p.L948I|NLRX1_ENST00000525863.1_Intron|NLRX1_ENST00000469103.2_3'UTR			Q86UT6	NLRX1_HUMAN	NLR family member X1	948	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGGTGCCACCCTTAATCCTTG	0.637000													3	39					0.150653	0.154001	0.150653	1	0
ANKEF1	63926	broad.mit.edu	37	20	10019172	10019172	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:10019172G>A	ENST00000378380.3	+	2	552	c.223G>A	c.(223-225)Gat>Aat	p.D75N	ANKEF1_ENST00000378392.1_Missense_Mutation_p.D75N|SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		TGCTCACCCTGATGTGCAAGA	0.448000													11	91					0	0	0.080935	0	0
COL12A1	1303	broad.mit.edu	37	6	75829168	75829168	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:75829168C>G	ENST00000322507.8	-	45	7417	c.7108G>C	c.(7108-7110)Gat>Cat	p.D2370H	COL12A1_ENST00000483888.2_Missense_Mutation_p.D2370H|COL12A1_ENST00000416123.2_Missense_Mutation_p.D2370H|COL12A1_ENST00000345356.6_Missense_Mutation_p.D1206H	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2370	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TTGACCTCATCGCTGTATTGC	0.433000													9	59					0	0	0.080935	0	0
FAM98A	25940	broad.mit.edu	37	2	33817277	33817277	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:33817277C>T	ENST00000403368.1	-	3	276	c.207G>A	c.(205-207)ccG>ccA	p.P69P	FAM98A_ENST00000441530.2_5'UTR|FAM98A_ENST00000238823.8_Silent_p.P69P|FAM98A_ENST00000498340.1_5'UTR	NM_015475.3	NP_056290.3	Q8NCA5	FA98A_HUMAN	family with sequence similarity 98, member A	69										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					CAGCTTCACTCGGACCTTTTA	0.353000													4	218					0	0	0.150653	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409469	56409469	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:56409469C>G	ENST00000544374.1	-	1	478	c.450G>C	c.(448-450)ttG>ttC	p.L150F	OR5AP2_ENST00000302981.1_Missense_Mutation_p.L149F			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						TAGCTATTAGCAAAAAGCAAA	0.463000													10	98					0	0	0.080935	0	0
FSHR	2492	broad.mit.edu	37	2	49190205	49190205	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:49190205C>A	ENST00000406846.2	-	10	1874	c.1755G>T	c.(1753-1755)atG>atT	p.M585I	FSHR_ENST00000304421.4_Missense_Mutation_p.M559I|FSHR_ENST00000541117.1_Missense_Mutation_p.M321I|FSHR_ENST00000346173.3_Missense_Mutation_p.M523I	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	585					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	AAATGGGTGCCATGCAGAGGA	0.522000									Gonadal Dysgenesis, 46 XX				20	69					3.99206e-14	5.49074e-14	0.189662	1	0
KRT26	353288	broad.mit.edu	37	17	38926577	38926577	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:38926577A>T	ENST00000335552.4	-	3	657	c.609T>A	c.(607-609)tgT>tgA	p.C203*		NM_181539.4	NP_853517.2	Q7Z3Y9	K1C26_HUMAN	keratin 26	203	Coil 1B.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(5)	16		Breast(137;0.00526)				GGTCGGTTGTACAAAGGGTCA	0.483000													21	101					0	0	0.234183	0	0
ABCC1	4363	broad.mit.edu	37	16	16110392	16110392	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:16110392G>A	ENST00000399408.2	+	5	704	c.529G>A	c.(529-531)Gtc>Atc	p.V177I	ABCC1_ENST00000399410.3_Missense_Mutation_p.V177I|ABCC1_ENST00000349029.5_Missense_Mutation_p.V177I|ABCC1_ENST00000346370.5_Missense_Mutation_p.V177I|ABCC1_ENST00000351154.5_Missense_Mutation_p.V177I|ABCC1_ENST00000345148.5_Missense_Mutation_p.V177I			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	177					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CACTTTCTACGTCTACTTTTC	0.512000													16	246					0	0	0.160694	0	0
EDARADD	128178	broad.mit.edu	37	1	236645924	236645924	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:236645924G>C	ENST00000359362.5	+	6	807	c.593G>C	c.(592-594)cGt>cCt	p.R198P	EDARADD_ENST00000334232.4_Missense_Mutation_p.R208P	NM_080738.3	NP_542776.1	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain	208	Death.				cell differentiation|signal transduction	cytoplasm		p.R208L(1)		endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|stomach(1)	12	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AAGCGGGAGCGTGGAGACCCC	0.582000													11	57					0	0	0.132662	0	0
CYP2B6	1555	broad.mit.edu	37	19	41509908	41509908	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:41509908C>A	ENST00000324071.4	+	2	181	c.174C>A	c.(172-174)ttC>ttA	p.F58L	CYP2B6_ENST00000593831.1_5'UTR|CYP2B6_ENST00000330446.5_Missense_Mutation_p.F18L|CYP2B6_ENST00000598834.1_3'UTR	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	58					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ATTGGCAGTTCCGAGAGAAAT	0.512000													6	45					8.12818e-05	9.27016e-05	0.248553	1	0
EYS	346007	broad.mit.edu	37	6	66005981	66005981	+	Silent	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:66005981A>G	ENST00000503581.1	-	12	2335	c.1798T>C	c.(1798-1800)Ttg>Ctg	p.L600L	EYS_ENST00000370621.3_Silent_p.L600L|EYS_ENST00000370616.2_Silent_p.L600L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	600	EGF-like 6.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						ACAACACACAATCTGCCAATG	0.378000													2	2					0	0	0.115264	0	0
NUP107	57122	broad.mit.edu	37	12	69096537	69096537	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:69096537A>T	ENST00000229179.4	+	8	1034	c.702A>T	c.(700-702)ttA>ttT	p.L234F	NUP107_ENST00000539906.1_Missense_Mutation_p.L205F|NUP107_ENST00000378905.2_Missense_Mutation_p.L83F	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	234					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AGTCTGCATTAGAAGAGGAAA	0.279000													8	24					0	0	0.047766	0	0
RBL1	5933	broad.mit.edu	37	20	35693826	35693826	+	Splice_Site	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:35693826C>G	ENST00000373664.3	-	7	963		c.e7+1		RBL1_ENST00000344359.3_Splice_Site	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)						cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				TAGATATTTACCTATTATCAG	0.308000													9	51					0	0	0.047766	0	0
TOX2	84969	broad.mit.edu	37	20	42694513	42694513	+	Silent	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:42694513C>G	ENST00000358131.5	+	6	1276	c.1068C>G	c.(1066-1068)gcC>gcG	p.A356A	TOX2_ENST00000341197.3_Silent_p.A374A|TOX2_ENST00000435864.2_Silent_p.A252A|TOX2_ENST00000423191.1_Silent_p.A332A|TOX2_ENST00000372999.1_Silent_p.A332A	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCAGCCTCGCCCGGACGCTGG	0.706000													11	19					0	0	0.160694	0	0
OR6C4	341418	broad.mit.edu	37	12	55945351	55945351	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:55945351C>G	ENST00000394256.2	+	1	369	c.341C>G	c.(340-342)gCc>gGc	p.A114G	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						TACCTCCTGGCCTCCATGTCT	0.438000													54	97					0	0	0.139131	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:7578413C>T	ENST00000420246.2	-	5	649	c.517G>A	c.(517-519)Gtg>Atg	p.V173M	TP53_ENST00000413465.2_Missense_Mutation_p.V173M|TP53_ENST00000269305.4_Missense_Mutation_p.V173M|TP53_ENST00000445888.2_Missense_Mutation_p.V173M|TP53_ENST00000455263.2_Missense_Mutation_p.V173M|TP53_ENST00000359597.4_Missense_Mutation_p.V173M|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	173	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(68)|p.V173M(46)|p.0?(8)|p.V80L(6)|p.V41L(6)|p.V173fs*1(4)|p.V80M(3)|p.V41M(3)|p.V173fs*59(2)|p.V157_C176del20(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	38					0	0	0.132662	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76572213	76572213	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:76572213C>G	ENST00000307431.8	+	20	3578	c.3193C>G	c.(3193-3195)Ctt>Gtt	p.L1065V	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.L993V|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.L1017V|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.L1069V|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1066	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CAAAGAATACCTTTCTGTGAT	0.358000													4	43					0	0	0.150653	0	0
FAM47B	170062	broad.mit.edu	37	X	34961693	34961693	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:34961693G>T	ENST00000329357.5	+	1	781	c.745G>T	c.(745-747)Gtg>Ttg	p.V249L		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	249	Pro-rich.							p.V249M(1)		breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCATCTCCGCGTGGATCCTCC	0.627000													16	49					2.48551e-13	3.38487e-13	0.160694	1	0
NCOA6	23054	broad.mit.edu	37	20	33345447	33345447	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:33345447C>A	ENST00000374796.2	-	8	3674	c.1104G>T	c.(1102-1104)acG>acT	p.T368T	NCOA6_ENST00000359003.2_Silent_p.T368T			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	368	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GGTGGGAAGGCGTCTGTACCG	0.577000													8	47					1.12685e-05	1.3329e-05	0.047766	1	0
OR2T34	127068	broad.mit.edu	37	1	248737278	248737278	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:248737278A>G	ENST00000328782.2	-	1	802	c.781T>C	c.(781-783)Ttc>Ctc	p.F261L		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAGGTGTAGAAGGAAGCACCG	0.557000													27	73					0	0	0.111260	0	0
DST	667	broad.mit.edu	37	6	56484807	56484807	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:56484807T>A	ENST00000370765.6	-	23	4132	c.4025A>T	c.(4024-4026)cAg>cTg	p.Q1342L	DST_ENST00000421834.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	4990					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGATGTAGCCTGTGTGATCGG	0.408000													16	90					0	0	0.204396	0	0
CCDC113	29070	broad.mit.edu	37	16	58296307	58296307	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:58296307G>C	ENST00000219299.4	+	6	725	c.646G>C	c.(646-648)Gcc>Ccc	p.A216P	CCDC113_ENST00000443128.2_Missense_Mutation_p.A162P	NM_014157.3	NP_054876.2	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113	216						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						GGTGAGTGAGGCCCTTCACGA	0.418000													17	100					0	0	0.160694	0	0
CUBN	8029	broad.mit.edu	37	10	16911667	16911667	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:16911667T>A	ENST00000377833.4	-	59	9487	c.9422A>T	c.(9421-9423)aAa>aTa	p.K3141I		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3141	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTTCCAGCCTTTTGCTGTCTG	0.428000													11	105					0	0	0.093190	0	0
PIH1D3	139212	broad.mit.edu	37	X	106462128	106462128	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:106462128C>T	ENST00000535523.1	+	5	598	c.261C>T	c.(259-261)gaC>gaT	p.D87D	PIH1D3_ENST00000372453.3_Silent_p.D87D|PIH1D3_ENST00000336387.4_Silent_p.D87D	NM_001169154.1	NP_001162625.1			PIH1 domain containing 3																		ATAATGAGGACATCTGGAATT	0.403000													4	43					0	0	0.184627	0	0
PABPC3	5042	broad.mit.edu	37	13	25671839	25671839	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:25671839C>T	ENST00000281589.3	+	1	1540	c.1503C>T	c.(1501-1503)cgC>cgT	p.R501R		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	501					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		ctgctgTGCGCACGGTTCCAC	0.532000													5	24					0	0	0.047766	0	0
RGPD3	653489	broad.mit.edu	37	2	107040987	107040987	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:107040987G>A	ENST00000409886.3	-	20	3523	c.3436C>T	c.(3436-3438)Cga>Tga	p.R1146*	RGPD3_ENST00000304514.7_Nonsense_Mutation_p.R1146*	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1146	RanBD1 1.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						GCTGCCAATCGCTCTAGTTTG	0.453000													32	169					0	0	0.163468	0	0
GGCX	2677	broad.mit.edu	37	2	85781383	85781383	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:85781383C>T	ENST00000233838.3	-	7	852	c.772G>A	c.(772-774)Ggt>Agt	p.G258S	GGCX_ENST00000430215.3_Missense_Mutation_p.G201S|GGCX_ENST00000473665.1_5'UTR	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	258					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	AGCAGCCCACCCCAGTGCACG	0.502000													6	86					0	0	0.038147	0	0
HOXD1	3231	broad.mit.edu	37	2	177054663	177054663	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:177054663C>G	ENST00000331462.4	+	2	1003	c.780C>G	c.(778-780)atC>atG	p.I260M		NM_024501.1	NP_078777.1	Q9GZZ0	HXD1_HUMAN	homeobox D1	260						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)		CCCGGCGCATCGAGATAGCCA	0.498000													31	194					0	0	0.163468	0	0
SPARC	6678	broad.mit.edu	37	5	151043764	151043764	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:151043764C>G	ENST00000231061.4	-	9	1080	c.767G>C	c.(766-768)cGt>cCt	p.R256P		NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	256					ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	GAGGGGAGCACGCAGTGGAGC	0.622000													9	23					0	0	0.047766	0	0
ARAP3	64411	broad.mit.edu	37	5	141059221	141059221	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:141059221G>T	ENST00000239440.4	-	4	654	c.589C>A	c.(589-591)Cac>Aac	p.H197N	ARAP3_ENST00000508305.1_Missense_Mutation_p.H119N	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	197					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TCCATGATGTGCACTGGCAGG	0.597000													5	22					3.59834e-05	4.18458e-05	0.217242	1	0
GARS	2617	broad.mit.edu	37	7	30643155	30643155	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:30643155A>C	ENST00000389266.3	+	6	943	c.702A>C	c.(700-702)gaA>gaC	p.E234D		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	234					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	GTTCTGTCGAAAAGAAATCAG	0.378000													4	37					0	0	0.184627	0	0
PDGFRA	5156	broad.mit.edu	37	4	55127551	55127551	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:55127551A>C	ENST00000257290.5	+	3	670	c.339A>C	c.(337-339)gaA>gaC	p.E113D	FIP1L1_ENST00000507166.1_Intron|PDGFRA_ENST00000508170.1_Missense_Mutation_p.E113D	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	113	Ig-like C2-type 1.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ATGAGCTTGAAGGCAGGCACA	0.483000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			33	166					0	0	0.225048	0	0
ASCL4	121549	broad.mit.edu	37	12	108169129	108169129	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:108169129C>A	ENST00000342331.4	+	1	968	c.137C>A	c.(136-138)gCg>gAg	p.A46E		NM_203436.2	NP_982260.2	Q6XD76	ASCL4_HUMAN	achaete-scute family bHLH transcription factor 4	45					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	13						CTGGACGCCGCGTGCTGGGAG	0.741000													3	6					6.4e-05	7.36162e-05	0.115264	1	0
DYTN	391475	broad.mit.edu	37	2	207527871	207527871	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:207527871G>T	ENST00000452335.2	-	11	1505	c.1389C>A	c.(1387-1389)acC>acA	p.T463T		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	463						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TTTGTGCCCTGGTGCTGTGCA	0.483000													5	69					0.014758	0.0153899	0.184627	1	0
ZIC3	7547	broad.mit.edu	37	X	136652166	136652166	+	Silent	SNP	A	A	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:136652166A>C	ENST00000287538.5	+	3	1891	c.1341A>C	c.(1339-1341)gcA>gcC	p.A447A	ZIC3_ENST00000370606.3_Intron	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	447					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					CCCCTTCTGCAGTTCAAACTA	0.463000													10	59					0	0	0.058154	0	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													10	122					0	0	0.069234	0	0
NPSR1	387129	broad.mit.edu	37	7	34867013	34867013	+	Splice_Site	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:34867013A>G	ENST00000360581.1	+	5	607	c.478_splice	c.e5-1	p.E160_splice	NPSR1_ENST00000381542.1_Splice_Site_p.E94_splice|NPSR1_ENST00000531252.1_Splice_Site_p.E149_splice|NPSR1_ENST00000381539.3_Splice_Site_p.E160_splice|NPSR1_ENST00000359791.1_Splice_Site_p.E160_splice	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	160						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CTTTGGGCAGAAAAGCAAGCC	0.502000													6	72					0	0	0.217242	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665877	19665877	+	Missense_Mutation	SNP	G	G	A	rs75574349	byFrequency	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:19665877G>A	ENST00000328041.6	+	12	1393	c.1196G>A	c.(1195-1197)cGg>cAg	p.R399Q		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	399						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AATGGGACACGGAGGGACGAT	0.532000													5	78					0	0	0.217242	0	0
ZNF582	147948	broad.mit.edu	37	19	56895314	56895314	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:56895314C>T	ENST00000301310.4	-	5	1630	c.1472G>A	c.(1471-1473)aGt>aAt	p.S491N	ZNF582_ENST00000586929.1_Missense_Mutation_p.S491N	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		TAAGGGGTAACTGCTGATGGA	0.388000													19	102					0	0	0.219247	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	50					0	0	0.217242	0	0
FAM47A	158724	broad.mit.edu	37	X	34149861	34149861	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:34149861G>C	ENST00000346193.3	-	1	586	c.535C>G	c.(535-537)Cct>Gct	p.P179A		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	179	Pro-rich.									NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TGTTTACCAGGCTCAGTGGGT	0.577000													25	51					0	0	0.099896	0	0
FAM135B	51059	broad.mit.edu	37	8	139153549	139153549	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:139153549G>T	ENST00000395297.1	-	17	3852	c.3682C>A	c.(3682-3684)Ctc>Atc	p.L1228I		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1228										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCCGTGTGAGGACCGATCGG	0.547000										HNSCC(54;0.14)			19	105					4.4004e-07	5.48725e-07	0.083992	1	0
KCNH5	27133	broad.mit.edu	37	14	63316464	63316464	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:63316464T>C	ENST00000322893.7	-	8	1744	c.1476A>G	c.(1474-1476)ctA>ctG	p.L492L	KCNH5_ENST00000394968.1_Silent_p.L434L|KCNH5_ENST00000420622.2_Silent_p.L492L	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	492					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GATAGAGTTTTAGGAAGTCCC	0.393000													20	89					0	0	0.234183	0	0
CSMD3	114788	broad.mit.edu	37	8	113569006	113569006	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:113569006A>G	ENST00000297405.5	-	25	4464	c.4220T>C	c.(4219-4221)cTg>cCg	p.L1407P	CSMD3_ENST00000352409.3_Missense_Mutation_p.L1407P|CSMD3_ENST00000343508.3_Missense_Mutation_p.L1367P|CSMD3_ENST00000455883.2_Missense_Mutation_p.L1303P	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1407	Sushi 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ACAGGAAGGCAGAGGATAGTC	0.408000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	52					0	0	0.058154	0	0
OR2L13	284521	broad.mit.edu	37	1	248262962	248262962	+	Silent	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:248262962A>T	ENST00000366478.2	+	3	622	c.285A>T	c.(283-285)ggA>ggT	p.G95G	OR2L13_ENST00000358120.2_Silent_p.G95G	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CCTTCCTGGGATGTGGTGTGC	0.547000													62	263					0	0	0.139131	0	0
TTC27	55622	broad.mit.edu	37	2	32961852	32961852	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:32961852T>G	ENST00000317907.4	+	12	1652	c.1421T>G	c.(1420-1422)aTt>aGt	p.I474S		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	474							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						GATGTTGTCATTTGTTATGAA	0.433000													7	16					0	0	0.248553	0	0
ITGB3	3690	broad.mit.edu	37	17	45368339	45368339	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:45368339A>G	ENST00000559488.1	+	9	1161	c.1145A>G	c.(1144-1146)gAg>gGg	p.E382G	ITGB3_ENST00000435993.2_Missense_Mutation_p.E335G|ITGB3_ENST00000571680.1_Missense_Mutation_p.E382G|ITGB3_ENST00000560629.1_Silent_p.R370R	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	382					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	TCTAAAGTAGAGCTGGAAGTG	0.488000													5	126					0	0	0.038147	0	0
TTN	7273	broad.mit.edu	37	2	179604128	179604128	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:179604128G>C	ENST00000589042.1	-	48	14056	c.13832C>G	c.(13831-13833)cCt>cGt	p.P4611R	TTN_ENST00000342175.6_Missense_Mutation_p.P4440R|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Missense_Mutation_p.P4248R|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P4294R|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P4373R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4294	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCACTAAAGGTGTATGTAT	0.423000													18	92					0	0	0.189662	0	0
SLC27A6	28965	broad.mit.edu	37	5	128362981	128362981	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:128362981G>T	ENST00000262462.4	+	7	2421	c.1411G>T	c.(1411-1413)Gac>Tac	p.D471Y	SLC27A6_ENST00000506176.1_Missense_Mutation_p.D471Y|SLC27A6_ENST00000395266.1_Missense_Mutation_p.D471Y			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	471					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CCAGGATCAGGACAATTTCCT	0.378000													10	59					3.86212e-05	4.46625e-05	0.069234	1	0
LAMA4	3910	broad.mit.edu	37	6	112463320	112463320	+	Splice_Site	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:112463320C>T	ENST00000230538.7	-	20	3065		c.e20+1		LAMA4_ENST00000389463.4_Splice_Site|LAMA4_ENST00000522006.1_Splice_Site|LAMA4_ENST00000424408.2_Splice_Site	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4						cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CATGTGCTTACGTTTTTGCTT	0.453000													16	52					0	0	0.132662	0	0
SLC17A3	10786	broad.mit.edu	37	6	25861921	25861921	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:25861921G>C	ENST00000397060.4	-	5	665	c.556C>G	c.(556-558)Cag>Gag	p.Q186E	SLC17A3_ENST00000361703.6_Missense_Mutation_p.Q108E|SLC17A3_ENST00000360657.3_Missense_Mutation_p.Q108E	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	108					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						ATTGCAAACTGACCCCCAAGT	0.393000													16	55					0	0	0.189662	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24250787	24250787	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:24250787C>A	ENST00000538205.1	+	0	530				ADAMDEC1_ENST00000522298.1_De_novo_Start_OutOfFrame|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Missense_Mutation_p.P74T|RP11-624C23.1_ENST00000519689.1_RNA	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1						integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AAGGTATGAACCTGAAGTTCA	0.284000													5	24					5.9392e-07	7.36176e-07	0.217242	1	0
ZNF514	84874	broad.mit.edu	37	2	95815962	95815962	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:95815962A>G	ENST00000295208.2	-	5	730	c.268T>C	c.(268-270)Tcc>Ccc	p.S90P	ZNF514_ENST00000411425.1_Missense_Mutation_p.S90P	NM_032788.1	NP_116177.1	Q96K75	ZN514_HUMAN	zinc finger protein 514	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						TCTTCTTTGGAAATTCCCCAA	0.378000													16	118					0	0	0.132662	0	0
TTN	7273	broad.mit.edu	37	2	179465807	179465807	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:179465807G>A	ENST00000589042.1	-	288	56048	c.55824C>T	c.(55822-55824)ggC>ggT	p.G18608G	TTN_ENST00000342175.6_Silent_p.G9735G|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Silent_p.G16040G|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Silent_p.G9543G|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.G16967G|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.G9668G	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16967	Fibronectin type-III 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACAGGGGAGCCCCCATCAT	0.478000													13	86					0	0	0.119110	0	0
RGL1	23179	broad.mit.edu	37	1	183885736	183885736	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:183885736G>T	ENST00000304685.3	+	17	2471	c.2010G>T	c.(2008-2010)tcG>tcT	p.S670S	RGL1_ENST00000367531.1_Silent_p.S670S|RGL1_ENST00000536277.1_Silent_p.S633S|RGL1_ENST00000539189.1_Silent_p.S606S|RGL1_ENST00000360851.3_Silent_p.S635S	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	635	Ras-associating.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						CCATTACCTCGACTGTGCTGC	0.507000													31	98					6.00712e-18	8.40185e-18	0.163468	1	0
LAMA2	3908	broad.mit.edu	37	6	129802476	129802476	+	Silent	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:129802476A>G	ENST00000421865.2	+	55	7690	c.7641A>G	c.(7639-7641)ggA>ggG	p.G2547G	RP1-69D17.3_ENST00000442449.1_RNA	NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2547	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGATGTAGGAACAGAAATCA	0.458000													14	100					0	0	0.119110	0	0
NAV3	89795	broad.mit.edu	37	12	78444689	78444689	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:78444689G>T	ENST00000397909.2	+	11	2451	c.2278G>T	c.(2278-2280)Ggt>Tgt	p.G760C	NAV3_ENST00000536525.2_Missense_Mutation_p.G760C|NAV3_ENST00000228327.6_Missense_Mutation_p.G760C|NAV3_ENST00000266692.7_Missense_Mutation_p.G760C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	760						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCCCTCCCTGGGTGCTGGCTA	0.597000										HNSCC(70;0.22)			7	30					1.6384e-10	2.19514e-10	0.248553	1	0
SLC4A10	57282	broad.mit.edu	37	2	162833373	162833373	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:162833373T>C	ENST00000375514.5	+	25	3561	c.3274T>C	c.(3274-3276)Ttt>Ctt	p.F1092L	SLC4A10_ENST00000446997.1_Missense_Mutation_p.F1111L|SLC4A10_ENST00000415876.2_Missense_Mutation_p.F1081L|SLC4A10_ENST00000272716.5_Missense_Mutation_p.F1081L|SLC4A10_ENST00000421911.1_Intron	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	1111					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GGAGTCAAGCTTTCCTTCCAA	0.318000													6	14					0	0	0.217242	0	0
CCDC129	223075	broad.mit.edu	37	7	31691641	31691641	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:31691641C>A	ENST00000319386.3	+	13	3349	c.2356C>A	c.(2356-2358)Caa>Aaa	p.Q786K	CCDC129_ENST00000409210.1_Missense_Mutation_p.Q842K|CCDC129_ENST00000451887.2_Missense_Mutation_p.Q960K|CCDC129_ENST00000407970.3_Missense_Mutation_p.Q934K			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	934										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CCGGGCTCAGCAAATCAGAGA	0.498000													8	28					1.12685e-05	1.3329e-05	0.047766	1	0
SMC1B	27127	broad.mit.edu	37	22	45750875	45750875	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr22:45750875T>C	ENST00000357450.4	-	20	3081	c.3082A>G	c.(3082-3084)Aag>Gag	p.K1028E	SMC1B_ENST00000404354.3_Missense_Mutation_p.K1028E	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	1028					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CTGACAGTCTTTAAGTTCTCC	0.413000													5	48					0	0	0.184627	0	0
NUP133	55746	broad.mit.edu	37	1	229631292	229631292	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:229631292T>A	ENST00000261396.3	-	8	1087	c.996A>T	c.(994-996)gaA>gaT	p.E332D	NUP133_ENST00000366679.1_Missense_Mutation_p.E332D|NUP133_ENST00000537506.1_Missense_Mutation_p.E316D	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	332					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CTTTAATAGCTTCATAGTTAC	0.323000													6	22					0	0	0.248553	0	0
GOLGA3	2802	broad.mit.edu	37	12	133381309	133381309	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:133381309G>T	ENST00000204726.3	-	7	2148	c.1590C>A	c.(1588-1590)gaC>gaA	p.D530E	GOLGA3_ENST00000537452.1_Missense_Mutation_p.D530E|GOLGA3_ENST00000456883.2_Missense_Mutation_p.D530E|GOLGA3_ENST00000450791.2_Missense_Mutation_p.D530E|GOLGA3_ENST00000545875.1_Missense_Mutation_p.D530E	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	530					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CACCTGTGTTGTCCTTGCTGA	0.652000													8	30					1.12685e-05	1.3329e-05	0.047766	1	0
CNTN1	1272	broad.mit.edu	37	12	41333204	41333204	+	Silent	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:41333204G>C	ENST00000551295.2	+	12	1413	c.1296G>C	c.(1294-1296)gtG>gtC	p.V432V	CNTN1_ENST00000547702.1_Silent_p.V432V|CNTN1_ENST00000347616.1_Silent_p.V432V|CNTN1_ENST00000360099.3_Silent_p.V432V|CNTN1_ENST00000547849.1_Silent_p.V432V|CNTN1_ENST00000348761.2_Silent_p.V421V	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	432	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GTGGAAGGGTGATAATTGAAT	0.398000													4	46					0	0	0.150653	0	0
KIF21A	55605	broad.mit.edu	37	12	39750632	39750632	+	Splice_Site	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:39750632A>G	ENST00000395670.3	-	10	1889		c.e10+1		KIF21A_ENST00000544797.2_Splice_Site|KIF21A_ENST00000541463.2_Splice_Site|KIF21A_ENST00000361961.3_Splice_Site|KIF21A_ENST00000361418.5_Splice_Site			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				CATGAACTATACCTGAGATCT	0.289000													9	41					0	0	0.058154	0	0
EFHC1	114327	broad.mit.edu	37	6	52303263	52303263	+	Silent	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:52303263A>T	ENST00000371068.5	+	3	550	c.447A>T	c.(445-447)atA>atT	p.I149I	EFHC1_ENST00000538167.1_Silent_p.I130I|EFHC1_ENST00000433625.2_Silent_p.I58I|EFHC1_ENST00000491749.1_3'UTR	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	149	DM10 1.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					GCAAGTTAATAAAACGCCAGC	0.423000													8	36					0	0	0.080935	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529899	80529899	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:80529899T>A	ENST00000295057.3	-	2	1702	c.1046A>T	c.(1045-1047)cAg>cTg	p.Q349L	CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000496558.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.Q349L|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000540488.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	349	LRRCT.					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GTCCTCGCCCTGTGCGTACTC	0.672000										HNSCC(69;0.2)			4	15					0	0	0.150653	0	0
MUC16	94025	broad.mit.edu	37	19	9071130	9071130	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:9071130G>T	ENST00000397910.4	-	3	16519	c.16316C>A	c.(16315-16317)tCt>tAt	p.S5439Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5441	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCTAGGACAGAGGATTGTGA	0.498000													34	263					3.09479e-21	4.37284e-21	0.246493	1	0
ZNF808	388558	broad.mit.edu	37	19	53058234	53058234	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:53058234G>A	ENST00000359798.4	+	5	2245	c.2065G>A	c.(2065-2067)Gtg>Atg	p.V689M		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	689					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CAAGGCTTTCGTGTGTCGTTC	0.423000													13	306					0	0	0.132662	0	0
MAOA	4128	broad.mit.edu	37	X	43590552	43590552	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:43590552A>G	ENST00000338702.3	+	7	833	c.710A>G	c.(709-711)cAa>cGa	p.Q237R	MAOA_ENST00000542639.1_Missense_Mutation_p.Q104R|MAOA_ENST00000497485.1_3'UTR	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	237					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTCGGAGACCAAGTGAAGCTG	0.458000													13	12					0	0	0.105934	0	0
OR8B4	283162	broad.mit.edu	37	11	124294638	124294638	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:124294638C>A	ENST00000356130.3	-	1	151	c.130G>T	c.(130-132)Ggc>Tgc	p.G44C		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GTGATCAAGCCCAAGTTGCCC	0.433000													8	84					1.06961e-07	1.35006e-07	0.038147	1	0
CLYBL	171425	broad.mit.edu	37	13	100518543	100518543	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:100518543G>C	ENST00000376355.3	+	5	613	c.582G>C	c.(580-582)aaG>aaC	p.K194N	CLYBL_ENST00000444838.2_Missense_Mutation_p.K194N|CLYBL_ENST00000339105.4_Missense_Mutation_p.K228N|CLYBL_ENST00000376354.1_Missense_Mutation_p.K194N|CLYBL_ENST00000376360.1_Missense_Mutation_p.K228N	NM_206808.2	NP_996531.1	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like	228					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding			NS(1)|kidney(6)|large_intestine(6)|lung(10)|skin(2)	25	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCCGGCAAAAGATTGTTGTCA	0.453000													9	102					0	0	0.080935	0	0
MMS22L	253714	broad.mit.edu	37	6	97676987	97676987	+	Missense_Mutation	SNP	C	C	A	rs141217754		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:97676987C>A	ENST00000275053.4	-	14	2087	c.1822G>T	c.(1822-1824)Gtg>Ttg	p.V608L	MMS22L_ENST00000369251.2_Missense_Mutation_p.V568L	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	608					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						TTCTTAGACACCAAGAATTCC	0.418000													15	59					1.35283e-19	1.89855e-19	0.146539	1	0
CCDC88A	55704	broad.mit.edu	37	2	55546086	55546086	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:55546086C>G	ENST00000436346.1	-	19	4058	c.3217G>C	c.(3217-3219)Gag>Cag	p.E1073Q	CCDC88A_ENST00000413716.2_Missense_Mutation_p.E1072Q|CCDC88A_ENST00000336838.6_Missense_Mutation_p.E1072Q|CCDC88A_ENST00000263630.8_Missense_Mutation_p.E1073Q|AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000599352.1_RNA|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000594078.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1073					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TTCTGTGTCTCAAGTTGCTTC	0.383000													5	40					0	0	0.217242	0	0
CLCA2	9635	broad.mit.edu	37	1	86913416	86913416	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:86913416G>T	ENST00000370565.4	+	11	2101	c.1939G>T	c.(1939-1941)Gag>Tag	p.E647*		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	647					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AGTTGAGCCAGAGACTGGAGA	0.433000													4	61					0.184627	0.188265	0.184627	1	0
DNER	92737	broad.mit.edu	37	2	230223358	230223358	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:230223358C>A	ENST00000341772.4	-	13	2246	c.2112G>T	c.(2110-2112)aaG>aaT	p.K704N		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	704					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GCCGGGATTTCTTTCCAAACC	0.368000													10	44					0.00829132	0.00893908	0.069234	1	0
OGFOD1	55239	broad.mit.edu	37	16	56485540	56485540	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:56485540C>T	ENST00000566157.1	+	1	139	c.16C>T	c.(16-18)Cca>Tca	p.P6S	OGFOD1_ENST00000568397.1_Missense_Mutation_p.P6S	NM_018233.3	NP_060703.3	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain containing 1	6							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8					Vitamin C(DB00126)	TGGGAAGCGGCCAGCGGAGCC	0.567000													6	47					0	0	0.248553	0	0
SLC24A2	25769	broad.mit.edu	37	9	19521004	19521004	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:19521004C>G	ENST00000341998.2	-	9	1685	c.1624G>C	c.(1624-1626)Gct>Cct	p.A542P	SLC24A2_ENST00000286344.3_Missense_Mutation_p.A525P	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	542					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GAGGTCCCAGCAGCCAAGATG	0.478000													10	32					0	0	0.058154	0	0
MAP1A	4130	broad.mit.edu	37	15	43821529	43821529	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:43821529C>A	ENST00000382031.1	+	5	8603	c.8572C>A	c.(8572-8574)Cgg>Agg	p.R2858R	MAP1A_ENST00000300231.5_Silent_p.R2620R|MAP1A_ENST00000399453.1_Silent_p.R2620R			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2620						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GTCCCCTGCACGGCGTCTGGA	0.647000													5	38					2.7689e-08	3.56001e-08	0.248553	1	0
ANO3	63982	broad.mit.edu	37	11	26669265	26669265	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:26669265T>A	ENST00000256737.3	+	24	3290	c.2438T>A	c.(2437-2439)cTt>cAt	p.L813H	ANO3_ENST00000531568.1_Missense_Mutation_p.L667H|ANO3_ENST00000537978.1_Missense_Mutation_p.L797H|ANO3_ENST00000525139.1_Missense_Mutation_p.L797H	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	813						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						GGTATCTGGCTTGGAATTCTC	0.313000													9	40					0	0	0.105934	0	0
C8A	731	broad.mit.edu	37	1	57351650	57351650	+	Silent	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:57351650G>A	ENST00000361249.3	+	7	1002	c.906G>A	c.(904-906)aaG>aaA	p.K302K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	302	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CACATTTTAAGATGAGGAAGG	0.388000													15	90					0	0	0.132662	0	0
IGF2	3481	broad.mit.edu	37	11	2161390	2161390	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:2161390C>A	ENST00000434045.2	-	2	521	c.137G>T	c.(136-138)cGc>cTc	p.R46L	IGF2_ENST00000300632.5_Intron|IGF2_ENST00000337883.6_Intron|IGF2_ENST00000381389.1_Intron	NM_001127598.1	NP_001121070.1	P01344	IGF2_HUMAN	insulin-like growth factor 2 (somatomedin A)	0	B.				glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)|kidney(1)|lung(1)|pancreas(1)|skin(1)|urinary_tract(1)	6		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		CACCGGGGTGCGTCTAAGTAG	0.602000													3	7					0.115264	0.119001	0.115264	1	0
GRID2	2895	broad.mit.edu	37	4	94411878	94411878	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:94411878G>T	ENST00000282020.4	+	12	2205	c.1947G>T	c.(1945-1947)acG>acT	p.T649T	GRID2_ENST00000510992.1_Silent_p.T554T	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	649					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CATCTTACACGGCAAACCTCG	0.438000													9	136					0.000442599	0.000495233	0.058154	1	0
NID2	22795	broad.mit.edu	37	14	52505684	52505684	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:52505684T>C	ENST00000216286.5	-	9	2037	c.2038A>G	c.(2038-2040)Aca>Gca	p.T680A	NID2_ENST00000541773.1_Missense_Mutation_p.T627A	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	680	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CTGGAACTTGTAGAGGTCACA	0.413000													6	31					0	0	0.217242	0	0
PIGO	84720	broad.mit.edu	37	9	35094351	35094351	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:35094351G>A	ENST00000378617.3	-	3	911	c.517C>T	c.(517-519)Cgt>Tgt	p.R173C	PIGO_ENST00000361778.2_Missense_Mutation_p.R173C|PIGO_ENST00000341666.3_Missense_Mutation_p.R173C|PIGO_ENST00000298004.5_Missense_Mutation_p.R173C	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	173					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AAGACTACACGCCTTCCTGCA	0.483000													11	87					0	0	0.105934	0	0
PCDH15	65217	broad.mit.edu	37	10	55582459	55582459	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:55582459G>T	ENST00000361849.3	-	34	5427	c.5033C>A	c.(5032-5034)aCt>aAt	p.T1678N	PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.T1607N|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.T1673N|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.T1676N|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.T1653N|PCDH15_ENST00000395432.2_Missense_Mutation_p.T1636N	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1676					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCTTGAAACAGTTGGCAAAGT	0.418000										HNSCC(58;0.16)			4	79					0.00909568	0.00963072	0.150653	1	0
TMCO2	127391	broad.mit.edu	37	1	40713903	40713903	+	Splice_Site	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:40713903G>T	ENST00000372766.3	+	1	330		c.e1+1		TMCO2_ENST00000468258.1_Intron	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2							integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			GTCAATTCAGGTTATACTCTT	0.333000													3	39					0.115264	0.119001	0.115264	1	0
HEPH	9843	broad.mit.edu	37	X	65392258	65392258	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:65392258A>G	ENST00000519389.1	+	3	570	c.391A>G	c.(391-393)Atc>Gtc	p.I131V	HEPH_ENST00000336279.5_5'UTR|HEPH_ENST00000419594.1_Missense_Mutation_p.I80V|HEPH_ENST00000441993.2_Missense_Mutation_p.I80V|HEPH_ENST00000343002.2_Missense_Mutation_p.I77V|HEPH_ENST00000374727.3_Missense_Mutation_p.I80V			Q9BQS7	HEPH_HUMAN	hephaestin	77	Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						CAAGAAGACCATCTATAAAGA	0.493000													3	35					0	0	0.150653	0	0
CYP4F12	66002	broad.mit.edu	37	19	15784478	15784478	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:15784478C>T	ENST00000550308.1	+	2	519	c.139C>T	c.(139-141)Cgg>Tgg	p.R47W	CYP4F12_ENST00000324632.9_Missense_Mutation_p.R47W	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					CAACTGCCGCCGGCTCCAGTG	0.597000													21	256					0	0	0.214465	0	0
IFI16	3428	broad.mit.edu	37	1	159002342	159002342	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:159002342A>T	ENST00000295809.7	+	7	1445	c.1190A>T	c.(1189-1191)aAt>aTt	p.N397I	IFI16_ENST00000368132.3_Missense_Mutation_p.N397I|IFI16_ENST00000430894.2_Missense_Mutation_p.N345I|IFI16_ENST00000448393.2_Missense_Mutation_p.N397I|IFI16_ENST00000359709.3_Missense_Mutation_p.N341I|IFI16_ENST00000368131.4_Missense_Mutation_p.N397I|IFI16_ENST00000340979.6_Missense_Mutation_p.N397I			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	397					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					CCGAGAAACAATGACCCCAAG	0.423000													19	113					0	0	0.083992	0	0
GP2	2813	broad.mit.edu	37	16	20335217	20335217	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:20335217C>A	ENST00000302555.5	-	3	605	c.456G>T	c.(454-456)gtG>gtT	p.V152V	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Silent_p.V152V|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	152						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCTTCACCAGCACCTCTGTTT	0.587000													4	41					0.00909568	0.00963072	0.150653	1	0
PDZRN4	29951	broad.mit.edu	37	12	41903696	41903696	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:41903696C>A	ENST00000298919.7	+	5	792	c.404C>A	c.(403-405)aCa>aAa	p.T135K	PDZRN4_ENST00000539469.2_Missense_Mutation_p.T137K|PDZRN4_ENST00000402685.2_Missense_Mutation_p.T395K			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	395	Gly-rich.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GCAGACAGAACAGAAGACTTT	0.373000													15	58					1.05317e-09	1.39301e-09	0.119110	1	0
PASK	23178	broad.mit.edu	37	2	242046118	242046118	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:242046118C>G	ENST00000405260.1	-	18	4533	c.3835G>C	c.(3835-3837)Gcg>Ccg	p.A1279P	PASK_ENST00000234040.4_Missense_Mutation_p.A1279P|PASK_ENST00000544142.1_Missense_Mutation_p.A1093P|PASK_ENST00000358649.4_Missense_Mutation_p.A1286P|PASK_ENST00000539818.1_Missense_Mutation_p.A1063P	NM_001252120.1	NP_001239049.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1279					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TCCAGGCTCGCAGCGGACAGA	0.522000													10	53					0	0	0.080935	0	0
STAB2	55576	broad.mit.edu	37	12	104031840	104031840	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:104031840T>A	ENST00000388887.2	+	8	960	c.756T>A	c.(754-756)tgT>tgA	p.C252*		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	252	EGF-like 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ATGCTCATTGTACGTACCTGG	0.498000													11	84					0	0	0.093190	0	0
TSPEAR	54084	broad.mit.edu	37	21	45987842	45987842	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:45987842C>G	ENST00000323084.4	-	2	195	c.130G>C	c.(130-132)Gcc>Ccc	p.A44P	TSPEAR_ENST00000397916.1_5'UTR	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	44					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CCGCTTGTGGCGCCATCAGAA	0.597000													5	36					0	0	0.217242	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839487	128839487	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:128839487C>T	ENST00000310343.9	-	22	5578	c.5579G>A	c.(5578-5580)aGc>aAc	p.S1860N	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.S1511N|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.S1511N	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1860	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CCTCAGGCTGCTCTGCTTCTG	0.572000													4	17					0	0	0.217242	0	0
OR5M3	219482	broad.mit.edu	37	11	56237921	56237921	+	Missense_Mutation	SNP	C	C	A	rs142752109		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:56237921C>A	ENST00000312240.2	-	1	93	c.53G>T	c.(52-54)cGt>cTt	p.R18L		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R18H(1)		NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					CCATTCTCGACGGCTCGTTAG	0.398000													18	55					1.33834e-09	1.76456e-09	0.189662	1	0
ZNF181	339318	broad.mit.edu	37	19	35231858	35231858	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:35231858A>G	ENST00000392232.3	+	6	872	c.704A>G	c.(703-705)aAc>aGc	p.N235S	ZNF181_ENST00000492450.1_Missense_Mutation_p.N191S|ZNF181_ENST00000459757.1_Missense_Mutation_p.N190S			Q2M3W8	ZN181_HUMAN	zinc finger protein 181	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TTAAAGAAGAACTTACCAAAA	0.323000													8	44					0	0	0.038147	0	0
OR5H1	26341	broad.mit.edu	37	3	97852218	97852218	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:97852218T>A	ENST00000354565.2	+	1	677	c.677T>A	c.(676-678)tTa>tAa	p.L226*	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						TTCGCAATCTTAAAAAAGAAA	0.338000													13	58					0	0	0.119110	0	0
C10orf90	118611	broad.mit.edu	37	10	128153272	128153272	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:128153272G>T	ENST00000284694.7	-	4	1647	c.1527C>A	c.(1525-1527)ttC>ttA	p.F509L	C10orf90_ENST00000544758.1_Missense_Mutation_p.F606L|C10orf90_ENST00000454341.1_Intron|C10orf90_ENST00000356858.3_Missense_Mutation_p.F462L	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	509								p.F509F(1)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TACCTTTGGGGAACTTGCTTT	0.458000													5	111					2.7689e-08	3.56001e-08	0.248553	1	0
DNAH2	146754	broad.mit.edu	37	17	7667441	7667441	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:7667441C>T	ENST00000572933.1	+	20	4646	c.3186C>T	c.(3184-3186)agC>agT	p.S1062S	DNAH2_ENST00000389173.2_Silent_p.S1062S			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1062	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCAGAATCAGCCGCCCTCCGC	0.647000													4	48					0	0	0.150653	0	0
CARD16	114769	broad.mit.edu	37	11	104915311	104915311	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:104915311C>T	ENST00000375706.2	-	2	99	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	CASP1_ENST00000415981.2_Intron|CASP1_ENST00000593315.1_Intron|CASP1_ENST00000598974.1_Intron|CARD16_ENST00000375704.3_Missense_Mutation_p.E28K|CASP1_ENST00000594519.1_Intron|CARD16_ENST00000525374.1_Missense_Mutation_p.E28K	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						TGTAATAATTCATCCAGTAAG	0.423000													12	352					0	0	0.093190	0	0
TRANK1	9881	broad.mit.edu	37	3	36898690	36898690	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:36898690T>A	ENST00000301807.6	-	12	2638	c.741A>T	c.(739-741)gaA>gaT	p.E247D	TRANK1_ENST00000429976.2_Missense_Mutation_p.E797D|TRANK1_ENST00000428977.2_Missense_Mutation_p.E247D	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	797					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TCTTCAGCATTTCTGAAGTGC	0.512000													51	191					0	0	0.139131	0	0
PEG3	5178	broad.mit.edu	37	19	57328638	57328638	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:57328638T>C	ENST00000326441.9	-	10	1535	c.1172A>G	c.(1171-1173)aAg>aGg	p.K391R	ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.K267R|PEG3_ENST00000593695.1_Missense_Mutation_p.K265R|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.K391R|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	391					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATAGCGCCTCTTTCTTTCAAG	0.448000													8	154					0	0	0.047766	0	0
KCND2	3751	broad.mit.edu	37	7	119915005	119915005	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:119915005C>A	ENST00000331113.4	+	1	1284	c.319C>A	c.(319-321)Cct>Act	p.P107T		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	107					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GCTCCACTATCCTCGCCACGA	0.507000													13	121					7.93312e-07	9.80392e-07	0.119110	1	0
BFSP2	8419	broad.mit.edu	37	3	133119134	133119134	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:133119134G>T	ENST00000302334.2	+	1	296	c.207G>T	c.(205-207)ttG>ttT	p.L69F		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	69	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						TAGGTGGCTTGGGTGCCCGTG	0.662000													4	13					0.150653	0.154001	0.150653	1	0
CDH6	1004	broad.mit.edu	37	5	31323411	31323411	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:31323411C>G	ENST00000265071.2	+	12	2634	c.2369C>G	c.(2368-2370)tCc>tGc	p.S790C		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	790					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GACAAAGACTCCTAATCTGTT	0.408000													15	74					0	0	0.175082	0	0
DSG1	1828	broad.mit.edu	37	18	28935116	28935116	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:28935116C>A	ENST00000257192.4	+	15	3169	c.2957C>A	c.(2956-2958)gCt>gAt	p.A986D	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.A345D	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	986	Gly/Ser-rich.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGCATGGGTGCTGGGAGCGGT	0.602000													15	85					6.31663e-08	8.04641e-08	0.132662	1	0
CARD16	114769	broad.mit.edu	37	11	104915140	104915140	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:104915140C>G	ENST00000375706.2	-	2	270	c.253G>C	c.(253-255)Gag>Cag	p.E85Q	CASP1_ENST00000415981.2_Intron|CASP1_ENST00000593315.1_Intron|CASP1_ENST00000598974.1_Intron|CARD16_ENST00000375704.3_Missense_Mutation_p.E85Q|CASP1_ENST00000594519.1_Intron|CARD16_ENST00000525374.1_Missense_Mutation_p.E85Q	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						CCCAGCGTCTCTGCCAGGTAA	0.473000													9	277					0	0	0.058154	0	0
KIF2B	84643	broad.mit.edu	37	17	51901229	51901229	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:51901229G>T	ENST00000268919.4	+	1	991	c.835G>T	c.(835-837)Gtg>Ttg	p.V279L		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	279	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAACGAGTTGGTGTACCAGTT	0.572000													3	37					0.004672	0.00505015	0.115264	1	0
PCDH15	65217	broad.mit.edu	37	10	55943338	55943338	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:55943338C>A	ENST00000373965.2	-	14	1871	c.1477G>T	c.(1477-1479)Ggt>Tgt	p.G493C	PCDH15_ENST00000395446.1_Missense_Mutation_p.G486C|PCDH15_ENST00000437009.1_Missense_Mutation_p.G486C|PCDH15_ENST00000395445.1_Missense_Mutation_p.G493C|PCDH15_ENST00000414778.1_Missense_Mutation_p.G491C|PCDH15_ENST00000395430.1_Missense_Mutation_p.G486C|PCDH15_ENST00000409834.1_Missense_Mutation_p.G97C|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.G486C|PCDH15_ENST00000373957.3_Missense_Mutation_p.G464C|PCDH15_ENST00000373955.1_Missense_Mutation_p.G486C|PCDH15_ENST00000395438.1_Missense_Mutation_p.G486C|PCDH15_ENST00000361849.3_Missense_Mutation_p.G486C|PCDH15_ENST00000395433.1_Missense_Mutation_p.G464C|PCDH15_ENST00000395432.2_Missense_Mutation_p.G449C	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	486	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCTTGTACACCATCAAATGCT	0.363000										HNSCC(58;0.16)			8	71					5.18039e-06	6.23454e-06	0.038147	1	0
WDR72	256764	broad.mit.edu	37	15	53889379	53889379	+	Silent	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:53889379G>T	ENST00000396328.1	-	18	3284	c.3045C>A	c.(3043-3045)tcC>tcA	p.S1015S	WDR72_ENST00000360509.5_Silent_p.S1015S|WDR72_ENST00000557913.1_Silent_p.S1012S|WDR72_ENST00000559418.1_Silent_p.S1025S	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1015								p.S1015S(1)		NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TCTCTGCCATGGACACTGGTT	0.448000													24	117					5.91797e-21	8.33346e-21	0.163468	1	0
C9orf84	158401	broad.mit.edu	37	9	114490023	114490023	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:114490023C>T	ENST00000394779.3	-	9	1659	c.1415G>A	c.(1414-1416)gGc>gAc	p.G472D	C9orf84_ENST00000318737.4_Missense_Mutation_p.G511D|C9orf84_ENST00000374287.3_Missense_Mutation_p.G511D|C9orf84_ENST00000394777.4_Missense_Mutation_p.G472D	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	511								p.G472D(1)|p.G511D(1)		breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTGTTTTTTGCCATGTTCAAA	0.338000													3	57					0	0	0.150653	0	0
BCAS3	54828	broad.mit.edu	37	17	59161875	59161875	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:59161875G>C	ENST00000589222.1	+	22	2443	c.2375G>C	c.(2374-2376)cGt>cCt	p.R792P	BCAS3_ENST00000588462.1_Missense_Mutation_p.R807P|BCAS3_ENST00000390652.5_Missense_Mutation_p.R807P|BCAS3_ENST00000407086.3_Missense_Mutation_p.R792P|BCAS3_ENST00000585744.1_Missense_Mutation_p.R578P|BCAS3_ENST00000588874.1_Missense_Mutation_p.R563P|BCAS3_ENST00000408905.3_Missense_Mutation_p.R792P			Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3	807						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GGGTCATCCCGTCCAGTCTCT	0.463000													9	29					0	0	0.058154	0	0
SPTA1	6708	broad.mit.edu	37	1	158585143	158585143	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:158585143C>A	ENST00000368148.3	-	48	6831	c.6651G>T	c.(6649-6651)gtG>gtT	p.V2217V	SPTA1_ENST00000368147.3_Silent_p.V2214V	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2217					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCCCCAGGTCCACAATCTTGG	0.493000													34	289					9.65963e-10	1.28176e-09	0.183431	1	0
LRP2	4036	broad.mit.edu	37	2	170042168	170042168	+	Silent	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:170042168C>A	ENST00000263816.3	-	50	9975	c.9690G>T	c.(9688-9690)gtG>gtT	p.V3230V		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3230					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AATCTAATGCCACAACATTGT	0.368000													12	81					3.35478e-16	4.66066e-16	0.132662	1	0
TNR	7143	broad.mit.edu	37	1	175360456	175360456	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:175360456C>A	ENST00000367674.1	-	7	2183	c.1475G>T	c.(1474-1476)cGc>cTc	p.R492L	TNR_ENST00000263525.2_Missense_Mutation_p.R492L	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	492	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.R492H(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AGGGGGGCTGCGGGCCTGTTC	0.547000													13	27					6.31663e-08	8.04641e-08	0.132662	1	0
SLCO1B1	10599	broad.mit.edu	37	12	21350115	21350115	+	Silent	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:21350115T>C	ENST00000256958.2	+	8	1059	c.963T>C	c.(961-963)aaT>aaC	p.N321N		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	321					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TTACCAAAAATGTGACTGGTA	0.313000													6	27					0	0	0.248553	0	0
EHHADH	1962	broad.mit.edu	37	3	184910322	184910322	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:184910322G>A	ENST00000231887.3	-	7	1939	c.1864C>T	c.(1864-1866)Cgc>Tgc	p.R622C	EHHADH_ENST00000456310.1_Missense_Mutation_p.R526C	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	622						peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	TATAAGCAGCGTTCAAGGATC	0.428000													9	85					0	0	0.080935	0	0
XIST	7503	broad.mit.edu	37	X	73070963	73070963	+	RNA	SNP	T	T	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:73070963T>C	ENST00000429829.1	-	0	1625					NR_001564.2																						CCATTTCTAATTGGTTGGGTT	0.498000													21	35					0	0	0.234183	0	0
WDR7	23335	broad.mit.edu	37	18	54605764	54605764	+	Splice_Site	SNP	G	G	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:54605764G>T	ENST00000254442.3	+	24	4043	c.3831_splice	c.e24-1	p.V1278_splice	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Splice_Site_p.V1245_splice	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	1278										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		TGTTTTGTAGGTACACAGACA	0.343000													3	40					0.004672	0.00505015	0.115264	1	0
WDR76	79968	broad.mit.edu	37	15	44158515	44158515	+	Silent	SNP	C	C	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:44158515C>T	ENST00000263795.6	+	13	1876	c.1806C>T	c.(1804-1806)caC>caT	p.H602H	WDR76_ENST00000381246.2_Silent_p.H538H|WDR76_ENST00000478130.1_3'UTR	NM_001167941.1|NM_024908.3	NP_001161413.1|NP_079184.2	Q9H967	WDR76_HUMAN	WD repeat domain 76	602										breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)	20		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		ATGCCATGCACCCAACTCGGT	0.433000													4	34					0	0	0.150653	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290890	141290890	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:141290890G>A	ENST00000247452.3	-	3	1231	c.884C>T	c.(883-885)cCa>cTa	p.P295L		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	295	MAGE.					cytoplasm|nucleus		p.P295L(1)		NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TTCATAATATGGAGGAGAACT	0.498000										HNSCC(46;0.14)			40	106					0	0	0.139131	0	0
GPR98	84059	broad.mit.edu	37	5	90002055	90002055	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:90002055C>G	ENST00000405460.2	+	38	8670	c.8574C>G	c.(8572-8574)atC>atG	p.I2858M		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2858					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAGGAGCTATCAATGTCACAT	0.363000													11	46					0	0	0.105934	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24250788	24250788	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:24250788C>A	ENST00000256412.4	+	3	441	c.221C>A	c.(220-222)cCt>cAt	p.P74H	ADAMDEC1_ENST00000522298.1_5'UTR|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	74					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AGGTATGAACCTGAAGTTCAA	0.284000													5	24					5.9392e-07	7.36176e-07	0.217242	1	0
PHF3	23469	broad.mit.edu	37	6	64422420	64422420	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:64422420A>G	ENST00000262043.3	+	16	5276	c.4936A>G	c.(4936-4938)Atc>Gtc	p.I1646V	PHF3_ENST00000393387.1_Missense_Mutation_p.I1646V			Q92576	PHF3_HUMAN	PHD finger protein 3	1646					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TCCACAGTTTATCAACCTGAA	0.428000													15	27					0	0	0.132662	0	0
PRDM1	639	broad.mit.edu	37	6	106555120	106555120	+	Missense_Mutation	SNP	A	A	T	rs76571405		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:106555120A>T	ENST00000369096.4	+	7	2471	c.2237A>T	c.(2236-2238)gAg>gTg	p.E746V	PRDM1_ENST00000369089.3_Missense_Mutation_p.E612V|PRDM1_ENST00000369091.2_Missense_Mutation_p.E710V	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	746					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GAGGACGTGGAGGATGACATC	0.502000			"""D, N, Mis, F, S"""		DLBCL								6	115					0	0	0.217242	0	0
ALG10B	144245	broad.mit.edu	37	12	38714474	38714474	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:38714474T>G	ENST00000308742.4	+	3	1197	c.881T>G	c.(880-882)tTt>tGt	p.F294C	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	294					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				CTATTCTACTTTTTTTCATTT	0.343000													7	115					0	0	0.058154	0	0
KIAA0754	643314	broad.mit.edu	37	1	39879036	39879037	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:39879036_39879037insC	ENST00000530275.1	+	1	2886_2887	c.2691_2692insC	c.(2689-2694)gtccccfs	p.VP897fs	MACF1_ENST00000289893.4_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000539005.1_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	897	Ala-rich.							p.E901fs*190(1)		central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGCTGCAGTGCCCCCCCCAGA	0.728													2	4	---	---	---	---					
RP11-191G24.1	0	broad.mit.edu	37	1	51999517	51999517	+	RNA	DEL	C	C	-	rs34571962		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:51999517delC	ENST00000426017.1	+	0	64				RP11-191G24.1_ENST00000415031.1_RNA																							ttttttctttctttttttttt	0.353													3	6	---	---	---	---					
RP11-147G16.1	0	broad.mit.edu	37	1	82684119	82684120	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:82684119_82684120insA	ENST00000420549.1	-	0	118																											TGAAGGAAAAGAAAAAAAAATG	0.356													2	4	---	---	---	---					
PKN2-AS1	101927891	broad.mit.edu	37	1	89032679	89032679	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:89032679delA	ENST00000458097.1	-	0	250				RP11-76N22.2_ENST00000425750.2_RNA																							ATTAAAGGATAAACATTAGCA	0.383													2	4	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121134091	121134091	+	RNA	DEL	G	G	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:121134091delG	ENST00000437515.1	-	0	329				RP11-343N15.5_ENST00000602412.1_lincRNA																							tattctagaaGGATAAATTAT	0.333													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142672992	142672993	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:142672992_142672993insC	ENST00000369381.2	-	0	2507																											CCTGctgaccaccccccactaa	0.520													3	4	---	---	---	---					
PDE4DIP	9659	broad.mit.edu	37	1	145014185	145014185	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:145014185delT	ENST00000493130.2	-	4	518	c.357delA	c.(355-357)tcfs	p.S119fs	PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000530740.1_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATCCAAAAGGTGAAAAAAAAA	0.512			T	PDGFRB	MPD								3	5	---	---	---	---					
LOC645166	645166	broad.mit.edu	37	1	148944038	148944038	+	RNA	DEL	A	A	-	rs76811044		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:148944038delA	ENST00000539543.1	+	0	254					NR_027355.1																						tccacctcagaaaaaaaaaaa	0.483													3	3	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152145708	152145709	+	RNA	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:152145708_152145709insG	ENST00000593011.1	+	0	296																											CTGATCTGGGTGGGGGGGGCAC	0.505													3	5	---	---	---	---					
KIRREL	55243	broad.mit.edu	37	1	158061152	158061152	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:158061152delG	ENST00000368172.1	+	7	731	c.719delG	c.(718-720)tgfs	p.W240fs	KIRREL_ENST00000360089.4_Frame_Shift_Del_p.W262fs|KIRREL_ENST00000368173.3_Frame_Shift_Del_p.W442fs|KIRREL_ENST00000416935.2_Frame_Shift_Del_p.W326fs|KIRREL_ENST00000359209.6_Frame_Shift_Del_p.W426fs|KIRREL_ENST00000392272.2_Frame_Shift_Del_p.W323fs			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	426	Ig-like C2-type 3.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					CCACAGGCATGGGCCTGGAAG	0.602													9	92	---	---	---	---					
RP1-15D23.2	0	broad.mit.edu	37	1	172803958	172803959	+	RNA	INS	-	-	AG	rs140819890	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:172803958_172803959insAG	ENST00000432694.1	+	0	223																											tggggaagcacagtcagtcagg	0.540													2	4	---	---	---	---					
RP1-35C21.2	0	broad.mit.edu	37	1	177426408	177426411	+	RNA	DEL	ATCT	ATCT	-	rs58942299		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:177426408_177426411delATCT	ENST00000438575.1	-	0	296																											gtttgccacaatctatctttcaag	0.422													3	4	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182203484	182203487	+	RNA	DEL	AAAC	AAAC	-	rs71958642		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:182203484_182203487delAAAC	ENST00000449842.1	-	0	410																											ctccttctcaaaacaaacaaacaa	0.436													4	3	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182263544	182263544	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:182263544delC	ENST00000449842.1	-	0	410																											CTTCAAGCCACCTCCAAAgag	0.498													2	4	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187161183	187161184	+	RNA	DEL	CA	CA	-	rs35868117		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:187161183_187161184delCA	ENST00000458683.1	+	0	105																											gctttctcaccacacacacaca	0.317													2	4	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187208297	187208298	+	RNA	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:187208297_187208298insG	ENST00000458683.1	+	0	105																											GAGGGTGTGGTGGGGGGGTGCC	0.396													2	4	---	---	---	---					
RP11-373J16.1	0	broad.mit.edu	37	1	188986729	188986729	+	RNA	DEL	G	G	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:188986729delG	ENST00000445072.1	+	0	239																											tttccagtttgccagtctgtc	0.418													2	4	---	---	---	---					
LINC01031	101929184	broad.mit.edu	37	1	193300513	193300513	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:193300513delC	ENST00000420807.1	+	0	194																											gtgtgtgccaccatgcccggc	0.532													2	4	---	---	---	---					
RP11-134G8.7	0	broad.mit.edu	37	1	201499898	201499899	+	RNA	INS	-	-	T	rs140738054	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:201499898_201499899insT	ENST00000454651.1	+	0	179																											CTCAGTCTGGGTTTACTGTAAT	0.475											OREG0014084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
RP11-815M8.1	0	broad.mit.edu	37	1	222078776	222078778	+	RNA	DEL	AAC	AAC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr1:222078776_222078778delAAC	ENST00000433576.1	-	0	327																											ATCCATATATAACAACAACAAAA	0.399													2	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14409419	14409420	+	RNA	INS	-	-	T	rs71398685		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:14409419_14409420insT	ENST00000418420.1	-	0	251					NR_103814.1																						aatcctttatcttttttttttt	0.381													4	1	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14519059	14519060	+	RNA	INS	-	-	A	rs149607590		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:14519059_14519060insA	ENST00000418420.1	-	0	116					NR_103814.1																						gactctgtctcaaaaaaaaaaC	0.460													3	5	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22503423	22503424	+	RNA	INS	-	-	TAG	rs5829828	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:22503423_22503424insTAG	ENST00000450551.1	-	0	70																											GTTCTCTAGTTtgtgtgtgtgt	0.347													4	2	---	---	---	---					
LINC00486	285045	broad.mit.edu	37	2	33132898	33132899	+	RNA	DEL	TG	TG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:33132898_33132899delTG	ENST00000414054.1	+	0	453					NR_027098.1																						tatgtggccttgtgtgtgtgtg	0.411													2	4	---	---	---	---					
AC073218.1	0	broad.mit.edu	37	2	34680513	34680513	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:34680513delT	ENST00000422558.1	+	0	475																											cttttttaacttttttttgtc	0.289													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52100715	52100716	+	RNA	INS	-	-	AC	rs72383151	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:52100715_52100716insAC	ENST00000440698.1	+	0	879																											atgaaatacatacacacacaca	0.401													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52454733	52454734	+	RNA	DEL	CA	CA	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:52454733_52454734delCA	ENST00000440698.1	+	0	879																											cgcacacacgcacacacacaca	0.381													3	3	---	---	---	---					
AC010967.2	0	broad.mit.edu	37	2	52952752	52952752	+	RNA	DEL	A	A	-	rs35572508		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:52952752delA	ENST00000421575.1	-	0	302																											AATGACTTGGAAAAAAAAAAA	0.323													2	4	---	---	---	---					
RP11-481J13.1	0	broad.mit.edu	37	2	56360161	56360162	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:56360161_56360162insT	ENST00000606639.1	+	0	159																											AGATCTAAttcttttttttttt	0.465													2	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58832453	58832454	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:58832453_58832454insT	ENST00000452840.1	+	0	195																											TACCTCCACCATTTTTTTTGGC	0.396													3	6	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	59082182	59082183	+	RNA	INS	-	-	A	rs140151055	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:59082182_59082183insA	ENST00000452840.1	+	0	434																											ataaatgtatcgggggaaaaag	0.337													4	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59841574	59841575	+	RNA	INS	-	-	G	rs112426093	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:59841574_59841575insG	ENST00000606382.1	-	0	236																											ctagatacaatgggggtacagg	0.450													2	4	---	---	---	---					
AC023115.2	0	broad.mit.edu	37	2	67338503	67338503	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:67338503delC	ENST00000452716.1	+	0	110				AC023115.1_ENST00000594329.1_lincRNA																							ccaggtacctccctcaacacg	0.453													2	4	---	---	---	---					
LOC644838	644838	broad.mit.edu	37	2	67421647	67421649	+	RNA	DEL	TTC	TTC	-	rs138275984		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:67421647_67421649delTTC	ENST00000433133.1	-	0	205				AC023115.2_ENST00000452716.1_lincRNA|AC023115.1_ENST00000594329.1_lincRNA	NR_038844.1																						tttctttttattcttttttctcc	0.399													3	6	---	---	---	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)del	p.E155del	ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													7	72	---	---	---	---					
AC073987.1	0	broad.mit.edu	37	2	103777481	103777481	+	RNA	DEL	G	G	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:103777481delG	ENST00000422683.1	-	0	213																											TTTTAGCACAGGGGTCAGGGC	0.413													2	4	---	---	---	---					
AC096669.2	0	broad.mit.edu	37	2	108117449	108117449	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:108117449delT	ENST00000414300.1	-	0	295																											AGATCAACTATTTTCCATGGC	0.373													3	3	---	---	---	---					
PGM5P3-AS1	101929127	broad.mit.edu	37	2	114294175	114294176	+	RNA	DEL	AT	AT	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:114294175_114294176delAT	ENST00000446595.1	-	0	90																											CTCGTATGACATGTGGGGTTGC	0.446													4	4	---	---	---	---					
AC097532.2	0	broad.mit.edu	37	2	133050244	133050245	+	RNA	DEL	TG	TG	-	rs8179688		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:133050244_133050245delTG	ENST00000440802.1	-	0	60																											gttttctggctgtttttttttt	0.297													3	5	---	---	---	---					
AC012501.2	0	broad.mit.edu	37	2	154419616	154419617	+	RNA	DEL	TC	TC	-	rs35691701		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:154419616_154419617delTC	ENST00000424322.1	-	0	429																											atttgtgtaatctctgtttatt	0.277													3	6	---	---	---	---					
AC012501.2	0	broad.mit.edu	37	2	154440827	154440827	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:154440827delC	ENST00000424322.1	-	0	429																											caagacacagcacagtattca	0.517													2	4	---	---	---	---					
LOC100131270	100131270	broad.mit.edu	37	2	159543400	159543400	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:159543400delC	ENST00000342892.4	-	0	275				AC005042.5_ENST00000449526.1_lincRNA|AC005042.4_ENST00000442666.1_RNA																							GGGAACATATCCAATTCTTCC	0.398													2	4	---	---	---	---					
LOC101927865	101927865	broad.mit.edu	37	2	208083835	208083835	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:208083835delT	ENST00000435643.1	+	0	393																											ATTTTGACACTTTTTTTTTTG	0.318													2	4	---	---	---	---					
LINC00607	646324	broad.mit.edu	37	2	216559362	216559363	+	RNA	INS	-	-	A	rs59410509	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:216559362_216559363insA	ENST00000445174.1	-	0	723				AC012668.2_ENST00000417485.2_lincRNA	NR_037195.1																						acccagccttgaaaaaaaaaat	0.396													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221351707	221351708	+	RNA	DEL	AG	AG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:221351707_221351708delAG	ENST00000414512.1	+	0	368																											agacagagacagagagagagag	0.436													3	5	---	---	---	---					
LOC151484	151484	broad.mit.edu	37	2	231755961	231755962	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr2:231755961_231755962insA	ENST00000415628.1	+	0	424				AC012507.3_ENST00000455128.1_RNA|AC012507.3_ENST00000447074.1_RNA	NR_038238.1																						ctctaaaaaagaaaaaaaaaaa	0.500													2	4	---	---	---	---					
AC026167.1	0	broad.mit.edu	37	3	6399542	6399542	+	RNA	DEL	A	A	-	rs11325381		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:6399542delA	ENST00000435651.1	+	0	95																											GAGCAGTGTTAAAAAAAAAAA	0.383													2	4	---	---	---	---					
LMCD1-AS1	100288428	broad.mit.edu	37	3	8090292	8090292	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:8090292delT	ENST00000446281.1	-	0	514																											TTTTCTACGCttttttttttt	0.443													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18555226	18555227	+	RNA	INS	-	-	TA	rs140664975	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:18555226_18555227insTA	ENST00000593741.1	+	0	234				AC144521.1_ENST00000596850.1_RNA|AC144521.1_ENST00000598740.1_RNA|AC144521.1_ENST00000414198.1_RNA|AC144521.1_ENST00000598498.1_RNA|AC144521.1_ENST00000595250.1_RNA|AC144521.1_ENST00000598688.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000598390.1_RNA|AC144521.1_ENST00000596277.1_RNA|AC144521.1_ENST00000456253.2_RNA|AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000599762.1_RNA|AC144521.1_ENST00000595865.1_RNA|AC144521.1_ENST00000593444.1_RNA																							TTAGATTtatgtatatatatat	0.307													3	3	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18933610	18933611	+	RNA	DEL	CT	CT	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:18933610_18933611delCT	ENST00000425799.2	+	0	463																											ctctccctcgctctctctctct	0.465													3	6	---	---	---	---					
AC018359.1	0	broad.mit.edu	37	3	34234065	34234065	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:34234065delC	ENST00000424786.1	+	0	159																											ATGCCATCCTCCACAAATTGC	0.383													2	4	---	---	---	---					
LINC00698	285401	broad.mit.edu	37	3	62984457	62984460	+	RNA	DEL	AGAG	AGAG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:62984457_62984460delAGAG	ENST00000468072.1	+	0	125					NR_027104.1																						ataaaaaggaagagagaaagctct	0.431													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64696627	64696627	+	RNA	DEL	A	A	-	rs35148462		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:64696627delA	ENST00000460833.1	+	0	430				ADAMTS9-AS2_ENST00000474768.1_RNA|ADAMTS9-AS2_ENST00000485174.1_RNA|ADAMTS9-AS2_ENST00000481312.1_RNA																							atgggacaataaaagtatcga	0.413													3	5	---	---	---	---					
RP11-543A18.1	0	broad.mit.edu	37	3	65170347	65170348	+	RNA	INS	-	-	T	rs34474839		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:65170347_65170348insT	ENST00000481004.1	+	0	119																											CATTTCTCTACTTTTTTTTTTT	0.322													2	4	---	---	---	---					
CTD-2021J15.1	0	broad.mit.edu	37	3	98709381	98709381	+	RNA	DEL	T	T	-	rs62924960		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:98709381delT	ENST00000474798.1	+	0	196																											GAATTTCTAATTTTTTTTTCA	0.348													4	2	---	---	---	---					
RP11-174O3.3	0	broad.mit.edu	37	3	120083438	120083439	+	RNA	DEL	AG	AG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:120083438_120083439delAG	ENST00000494869.1	+	0	219																											aaactggaaaagagagagagag	0.436													2	4	---	---	---	---					
TFP1	100129696	broad.mit.edu	37	3	133424119	133424119	+	RNA	DEL	A	A	-	rs56933033		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:133424119delA	ENST00000460564.1	+	0	381																											actccatctcaaaaaaaaaaa	0.463													4	2	---	---	---	---					
CLRN1-AS1	116933	broad.mit.edu	37	3	150750904	150750906	+	RNA	DEL	AAC	AAC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:150750904_150750906delAAC	ENST00000476886.1	+	0	123				RP11-166N6.2_ENST00000469268.1_RNA|CLRN1-AS1_ENST00000465576.1_RNA																							CATGACAGTTAACAACATTTGGA	0.350													6	3	---	---	---	---					
EGFEM1P	93556	broad.mit.edu	37	3	168543379	168543379	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:168543379delT	ENST00000483846.1	+	0	805					NR_021485.2																						TAAGAACCTATTAGACTAGAA	0.363													2	4	---	---	---	---					
GMNC	647309	broad.mit.edu	37	3	190573662	190573663	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:190573662_190573663insT	ENST00000442080.1	-	5	425_426	c.426_427insA	c.(424-429)aatcagfs	p.NQ142fs	GMNC_ENST00000479491.1_5'UTR	NM_001146686.2	NP_001140158.1	A6NCL1	GEMC1_HUMAN	geminin coiled-coil domain containing	142					cell cycle|cell proliferation|DNA replication	nucleus	chromatin binding			NS(1)|endometrium(3)|skin(1)	5						CCCTTCCTGAATTTTCCATATG	0.347													2	4	---	---	---	---					
ANKRD18DP	348840	broad.mit.edu	37	3	197794331	197794331	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr3:197794331delT	ENST00000435620.2	-	0	921					NR_003291.1																						TTGCTCCTCCTTTTCTAAAAC	0.413													2	4	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14562319	14562319	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:14562319delT	ENST00000505089.1	-	0	461																											GTCCTTTGTCTTTTTTCCACC	0.358													2	4	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15175939	15175940	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:15175939_15175940insA	ENST00000502344.1	-	0	154				RP11-665G4.1_ENST00000513384.1_RNA																							ctgaccggcttaaaaaacggca	0.530													2	4	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19837705	19837706	+	RNA	INS	-	-	T	rs35369198	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:19837705_19837706insT	ENST00000511431.1	+	0	288																											CTGCAGGATAGTTACTGGCGAA	0.386													6	3	---	---	---	---					
LOC101929199	101929199	broad.mit.edu	37	4	27247857	27247859	+	RNA	DEL	GCT	GCT	-	rs76077112		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:27247857_27247859delGCT	ENST00000512873.1	+	0	360																											gaattcctgagctcaagcaatcc	0.463													5	3	---	---	---	---					
AC109351.1	0	broad.mit.edu	37	4	29751861	29751861	+	RNA	DEL	A	A	-	rs149531054		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:29751861delA	ENST00000390756.1	+	0	44																											CTTGAGAAGGAAAAAAAAAAT	0.308													2	4	---	---	---	---					
LOC101928622	101928622	broad.mit.edu	37	4	34031233	34031233	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:34031233delA	ENST00000505018.1	-	0	59																											taggaatgctaaaatatgcag	0.328													2	4	---	---	---	---					
RP11-63A11.1	0	broad.mit.edu	37	4	42383458	42383458	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:42383458delC	ENST00000503321.1	-	0	59				RP11-63A11.1_ENST00000508911.1_RNA|RP11-63A11.1_ENST00000515392.1_RNA																							tgaatttagtcggtgaaagag	0.438													2	4	---	---	---	---					
LINC00989	100506035	broad.mit.edu	37	4	80417221	80417221	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:80417221delT	ENST00000508174.1	+	0	642																											GTTAAAAATCTTTTTTGCTAT	0.289													2	4	---	---	---	---					
RP11-742B18.1	0	broad.mit.edu	37	4	88600201	88600232	+	RNA	DEL	TTACTTAATTACTTGTCCATCTTTCTTCTCTT	TTACTTAATTACTTGTCCATCTTTCTTCTCTT	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:88600201_88600232delTTACTTAATTACTTGTCCATCTTTCTTCTCTT	ENST00000506480.1	-	0	187																											GTATCATACATTACTTAATTACTTGTCCATCTTTCTTCTCTTTTTTTTTGGT	0.280													3	4	---	---	---	---					
RP11-554D13.1	0	broad.mit.edu	37	4	95599799	95599802	+	RNA	DEL	AACT	AACT	-	rs58963931		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:95599799_95599802delAACT	ENST00000514304.1	+	0	94																											AACTAGAATAAACTAACTAGCAAC	0.377													3	4	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100261040	100261041	+	RNA	INS	-	-	A	rs138827617	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:100261040_100261041insA	ENST00000515683.1	-	0	1316					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AGTGCTTTCACAAAAAAAATCA	0.327													4	2	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105466079	105466080	+	RNA	INS	-	-	T	rs151288430	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:105466079_105466080insT	ENST00000500179.1	+	0	96																											gcgtttttttgtttttttttgt	0.356													2	4	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105550748	105550749	+	RNA	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:105550748_105550749insG	ENST00000500179.1	+	0	96																											ggatcccagaagggggcaaatt	0.416													2	4	---	---	---	---					
RP11-556I14.2	0	broad.mit.edu	37	4	105823164	105823164	+	RNA	DEL	T	T	-	rs76592144		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:105823164delT	ENST00000515127.1	-	0	366																											TTAAAGGAGCTTTTTTTTTTT	0.368													2	4	---	---	---	---					
CTD-2325B11.1	0	broad.mit.edu	37	4	125133310	125133311	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:125133310_125133311insA	ENST00000507299.1	-	0	53																											ccatctcagttaaaaaaaaaTA	0.436													2	4	---	---	---	---					
CTD-2012I17.1	0	broad.mit.edu	37	4	135721771	135721772	+	RNA	DEL	GA	GA	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:135721771_135721772delGA	ENST00000504882.1	+	0	344																											aacatgaggggagagagagaga	0.312													2	4	---	---	---	---					
RP11-284M14.1	0	broad.mit.edu	37	4	144074432	144074432	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:144074432delT	ENST00000507826.1	-	0	354																											actcctgctcttttttttttt	0.333													2	4	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187542211	187542211	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr4:187542211delA	ENST00000441802.2	-	10	5738	c.5529delT	c.(5527-5529)ttfs	p.F1843fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1843	Cadherin 16.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CGGTAAAGTGAAAAATACTTG	0.393										HNSCC(5;0.00058)			20	38	---	---	---	---					
RP11-419C19.2	0	broad.mit.edu	37	5	13007891	13007891	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:13007891delT	ENST00000510065.1	-	0	166																											gctcaaaccattttttttgag	0.373													2	4	---	---	---	---					
LOC102723526	102723526	broad.mit.edu	37	5	17454412	17454427	+	RNA	DEL	GAAAGCAAAGCTCAGG	GAAAGCAAAGCTCAGG	-	rs144669763		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:17454412_17454427delGAAAGCAAAGCTCAGG	ENST00000504998.1	+	0	225																											AGAAAACTGAGAAAGCAAAGCTCAGGGAAAGCAAAG	0.421													2	4	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21534245	21534246	+	RNA	INS	-	-	TG	rs143137704		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:21534245_21534246insTG	ENST00000607545.1	+	0	314					NR_027026.1																						GCAGGTGTGTCTGTCACAAACA	0.520													3	6	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21539903	21539903	+	RNA	DEL	A	A	-	rs5866503		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:21539903delA	ENST00000607545.1	+	0	314					NR_027026.1																						ttctcacagcaaaaaaagata	0.294													6	3	---	---	---	---					
CTC-261N6.1	0	broad.mit.edu	37	5	85655999	85656000	+	RNA	INS	-	-	AT			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:85655999_85656000insAT	ENST00000511940.1	+	0	277																											GAGGCAAAAAAATCAATATCAA	0.307													2	4	---	---	---	---					
RP11-114J13.1	0	broad.mit.edu	37	5	125425909	125425909	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:125425909delA	ENST00000450613.2	-	0	226																											gtcgcaacccaaaatctcctt	0.343													2	4	---	---	---	---					
GS1-39E22.2	0	broad.mit.edu	37	5	135233346	135233347	+	RNA	INS	-	-	T	rs141923033	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:135233346_135233347insT	ENST00000522973.1	+	0	21_22																											TGGCAATACTGTTTTTTTTCAT	0.426													3	6	---	---	---	---					
CTB-57H20.1	0	broad.mit.edu	37	5	143037431	143037432	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:143037431_143037432insA	ENST00000503323.1	+	0	104																											GTGACTTCCCCAAAAACATGTA	0.411													2	4	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151465274	151465275	+	RNA	INS	-	-	T	rs72571539		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:151465274_151465275insT	ENST00000524295.1	+	0	199																											GCAGTCTGCCCTTTTTTTTTTT	0.480													5	4	---	---	---	---					
RP11-167P20.1	0	broad.mit.edu	37	5	162034276	162034277	+	RNA	DEL	AT	AT	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:162034276_162034277delAT	ENST00000517722.1	-	0	127																											AGTTAGTTGCATGTGGTAGATT	0.332													2	4	---	---	---	---					
RP11-541P9.3	0	broad.mit.edu	37	5	162573485	162573485	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr5:162573485delC	ENST00000509211.1	-	0	117				RP11-541P9.3_ENST00000458002.2_RNA																							cccagtgagaccaacgcagaa	0.473													2	4	---	---	---	---					
RP11-428J1.4	0	broad.mit.edu	37	6	5052602	5052603	+	RNA	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:5052602_5052603insG	ENST00000606227.1	-	0	346																											aatagctgaaagggggtaggag	0.322													2	4	---	---	---	---					
LOC101929006	101929006	broad.mit.edu	37	6	29205459	29205460	+	RNA	INS	-	-	T	rs9280569	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:29205459_29205460insT	ENST00000441381.1	+	0	79																											tagccatactgtttccacattg	0.376													5	1	---	---	---	---					
LOC101929006	101929006	broad.mit.edu	37	6	29228332	29228332	+	RNA	DEL	C	C	-	rs144062472		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:29228332delC	ENST00000441381.1	+	0	79																											TGGTAGGTTACCCAAATATTG	0.413													8	3	---	---	---	---					
RP3-331H24.5	0	broad.mit.edu	37	6	72045666	72045666	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:72045666delA	ENST00000602823.1	-	0	267																											AGAAAACAGCAAATACCAAAG	0.343													2	4	---	---	---	---					
UFL1-AS1	100861530	broad.mit.edu	37	6	96893358	96893358	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:96893358delT	ENST00000430796.1	-	0	110																											TGGTTGTTGGttttttttttt	0.373													3	3	---	---	---	---					
RP3-399L15.2	0	broad.mit.edu	37	6	114850939	114850940	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:114850939_114850940insT	ENST00000435802.1	-	0	160																											gatgtttagcattttttcagat	0.342													2	4	---	---	---	---					
LOC153910	153910	broad.mit.edu	37	6	142857046	142857047	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:142857046_142857047insT	ENST00000447311.1	-	0	364					NR_027312.1																						AGGACACACCATTTTTTTTCAC	0.411													2	4	---	---	---	---					
LOC153910	153910	broad.mit.edu	37	6	142935439	142935439	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:142935439delT	ENST00000447311.1	-	0	177					NR_027312.1																						tgcagcctcctcaGGTGCTCA	0.507													2	4	---	---	---	---					
RAET1E-AS1	100652739	broad.mit.edu	37	6	150225575	150225575	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:150225575delC	ENST00000606915.1	+	0	889				RP11-244K5.1_ENST00000446954.1_RNA|RP11-244K5.1_ENST00000605899.1_RNA	NR_045126.1																						GGATGACATTCCCCCAGGTGA	0.552													2	4	---	---	---	---					
RP1-111C20.4	0	broad.mit.edu	37	6	159424700	159424700	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:159424700delT	ENST00000607391.1	+	0	236				RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA																							gggctgatcattttctagttt	0.468													2	4	---	---	---	---					
RP11-503C24.2	0	broad.mit.edu	37	6	168626579	168626581	+	RNA	DEL	CCT	CCT	-	rs36227106		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr6:168626579_168626581delCCT	ENST00000424343.1	-	0	209																											tcctcctccccctcctcctcctt	0.581													2	4	---	---	---	---					
AC073316.1	0	broad.mit.edu	37	7	3326743	3326743	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:3326743delC	ENST00000437354.1	-	0	224																											gttgcccctacccccccttgc	0.502													2	4	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11402095	11402096	+	RNA	DEL	AC	AC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:11402095_11402096delAC	ENST00000421121.1	+	0	113				AC004538.3_ENST00000599875.1_RNA|AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000445839.1_RNA																							ctaagattgaacaCACACACAC	0.292													2	4	---	---	---	---					
FAM126A	84668	broad.mit.edu	37	7	22944489	22944490	+	RNA	INS	-	-	A	rs72005665		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:22944489_22944490insA	ENST00000421730.1	-	0	137																											gactttgtctcaaaaaaaaaaa	0.450													4	5	---	---	---	---					
LINC01446	401337	broad.mit.edu	37	7	53812092	53812093	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:53812092_53812093insA	ENST00000380970.2	-	0	1381					NR_038371.1																						tgggtgaccccactcactcaca	0.550													6	2	---	---	---	---					
AC003991.3	0	broad.mit.edu	37	7	87905415	87905415	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:87905415delT	ENST00000600908.1	+	0	93				AC003991.3_ENST00000595121.1_RNA|AC003991.3_ENST00000447758.1_RNA|AC003991.3_ENST00000594469.1_RNA																							aaggaaagccttttttacctc	0.488													3	3	---	---	---	---					
AZGP1P1	646282	broad.mit.edu	37	7	99581178	99581179	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:99581178_99581179insC	ENST00000425474.1	+	0	499_500					NR_036679.1																						TCCGCATCCCACCCCCCCCACA	0.579													4	7	---	---	---	---					
C7orf13	129790	broad.mit.edu	37	7	156268628	156268628	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr7:156268628delC	ENST00000447933.1	-	0	300																											gccagccctgcctccacccca	0.562													2	4	---	---	---	---					
AC100802.3	0	broad.mit.edu	37	8	19947176	19947176	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:19947176delT	ENST00000519197.1	+	0	218																											aatctacCAAttttttttttt	0.428													3	6	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24452271	24452271	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:24452271delT	ENST00000519689.1	-	0	184																											CATGATGATATTTTTTTTCCT	0.378													2	4	---	---	---	---					
RP11-566H8.3	0	broad.mit.edu	37	8	31228941	31228942	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:31228941_31228942insC	ENST00000524022.1	+	0	213																											aggtagtccttcccccttgctt	0.406													2	4	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36444679	36444680	+	RNA	DEL	AG	AG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:36444679_36444680delAG	ENST00000524132.1	-	0	484																											agagaggggaagagagagagag	0.455													2	4	---	---	---	---					
RP11-758M4.4	0	broad.mit.edu	37	8	75711236	75711238	+	RNA	DEL	TTG	TTG	-	rs112128689		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:75711236_75711238delTTG	ENST00000523860.1	-	0	553_555																											GAAAGtgtttttgttgttgttgt	0.394													2	4	---	---	---	---					
RP11-354A14.1	0	broad.mit.edu	37	8	82812974	82812974	+	RNA	DEL	G	G	-	rs78896556		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:82812974delG	ENST00000534675.1	+	0	64																											aggaaggaaaggagttgttgt	0.408													3	3	---	---	---	---					
RP11-386D6.2	0	broad.mit.edu	37	8	87798145	87798145	+	RNA	DEL	G	G	-	rs34991054		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:87798145delG	ENST00000520649.1	+	0	449																											ttttgggcttgtctggggtac	0.453													4	2	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91331458	91331458	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:91331458delT	ENST00000523406.1	+	0	300					NR_051989.1																						CTAAGAGGCGTTACAGCAAAG	0.393													2	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117022373	117022373	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:117022373delT	ENST00000505156.2	-	0	1558					NR_046215.1																						CTTACCATAGTTTTATGATCA	0.308													2	4	---	---	---	---					
RP11-785H20.1	0	broad.mit.edu	37	8	122900531	122900532	+	RNA	DEL	AG	AG	-	rs143727205		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:122900531_122900532delAG	ENST00000523550.1	+	0	161																											ttgtccatgaagagagatagga	0.371													4	2	---	---	---	---					
RP11-398G24.2	0	broad.mit.edu	37	8	123005141	123005142	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:123005141_123005142insT	ENST00000523792.1	-	0	160																											CAATTCCCCCCCAATTCTAGAA	0.337													2	4	---	---	---	---					
FER1L6-AS2	157376	broad.mit.edu	37	8	125157641	125157641	+	RNA	DEL	C	C	-	rs36045593		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:125157641delC	ENST00000520031.1	-	0	95					NR_103547.1																						AATACCCATTCCCCCTCGCCT	0.458													4	3	---	---	---	---					
CASC8	727677	broad.mit.edu	37	8	128336140	128336141	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:128336140_128336141insC	ENST00000502082.1	-	0	1176				CASC8_ENST00000523825.1_RNA|CASC8_ENST00000501396.1_RNA																							tggatgtttgtcccctccaaat	0.450													2	4	---	---	---	---					
EEF1D	1936	broad.mit.edu	37	8	144663326	144663327	+	Splice_Site	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr8:144663326_144663327insG	ENST00000532741.1	-	5	1766		c.e5-2		EEF1D_ENST00000317198.6_Splice_Site|EEF1D_ENST00000531621.1_Splice_Site|EEF1D_ENST00000526838.1_Splice_Site|EEF1D_ENST00000528610.1_Splice_Site|EEF1D_ENST00000395119.3_Splice_Site|EEF1D_ENST00000419152.2_Splice_Site|EEF1D_ENST00000524624.1_Splice_Site|EEF1D_ENST00000529272.1_Splice_Site|EEF1D_ENST00000442189.2_Splice_Site|EEF1D_ENST00000423316.2_Splice_Site|EEF1D_ENST00000532400.1_Intron			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)						positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CCTGTACCACTGGGGGGGCAAG	0.693													4	7	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68407616	68407616	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:68407616delA	ENST00000417843.2	-	0	67																											tggatcaagcagaagaaatag	0.343													3	3	---	---	---	---					
LOC101928438	101928438	broad.mit.edu	37	9	102371817	102371818	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:102371817_102371818insT	ENST00000427039.1	-	0	319																											ctgggctatgctttttatgtgt	0.436													2	4	---	---	---	---					
LINC00587	414319	broad.mit.edu	37	9	105304091	105304094	+	RNA	DEL	TTTC	TTTC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:105304091_105304094delTTTC	ENST00000374801.3	+	0	73					NR_103830.1																						aaaatgcctttttctttatctctg	0.397													5	1	---	---	---	---					
RP11-202G18.1	0	broad.mit.edu	37	9	114015015	114015016	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr9:114015015_114015016insT	ENST00000426204.1	-	0	370																											ctttaaacctctttttcttata	0.416													2	4	---	---	---	---					
RP11-69C17.4	0	broad.mit.edu	37	10	2212600	2212600	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:2212600delC	ENST00000418524.2	-	0	474																											TTCTTGTCTTCCCCCCTTTTA	0.398													2	4	---	---	---	---					
TMEM72-AS1	220980	broad.mit.edu	37	10	45404304	45404304	+	RNA	DEL	G	G	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:45404304delG	ENST00000450287.2	-	0	244				RP11-285G1.2_ENST00000436877.2_RNA	NR_033842.1																						AAAAGGACGTGGGGAGAGCAC	0.512													2	4	---	---	---	---					
LOC101926942	101926942	broad.mit.edu	37	10	92240754	92240755	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:92240754_92240755insA	ENST00000422206.1	+	0	146				RP11-15K3.1_ENST00000418379.1_lincRNA																							tctatacaaacaaaaatgaaca	0.351													2	4	---	---	---	---					
RP11-381K7.1	0	broad.mit.edu	37	10	113111165	113111165	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr10:113111165delA	ENST00000421597.1	-	0	167																											atagtaaactaaggctcagag	0.393													2	4	---	---	---	---					
LOC100506082	100506082	broad.mit.edu	37	11	4209890	4209891	+	RNA	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:4209890_4209891insG	ENST00000525365.1	+	0	65					NR_047550.1																						cataggaatttgggggggcaca	0.525													2	4	---	---	---	---					
RP11-222N13.1	0	broad.mit.edu	37	11	15939590	15939590	+	RNA	DEL	A	A	-	rs75082724		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:15939590delA	ENST00000530418.1	+	0	217																											TTTCAGGTGGAAAAAAAAAAT	0.408													2	4	---	---	---	---					
OR7E14P	10819	broad.mit.edu	37	11	17045795	17045796	+	RNA	INS	-	-	AC	rs35808573		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:17045795_17045796insAC	ENST00000530490.1	+	0	370																											CCCATACCCCAAAacacacaca	0.535													2	4	---	---	---	---					
OR1S1	219959	broad.mit.edu	37	11	57982229	57982229	+	Frame_Shift_Del	DEL	A	A	-	rs1966836	byFrequency	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:57982229delA	ENST00000309433.6	+	1	13	c.13delA	c.(13-15)gtfs	p.S6fs		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				GAAGACTTTTAGTTCCTTTCT	0.378													10	68	---	---	---	---					
RP11-626H12.1	0	broad.mit.edu	37	11	69850399	69850400	+	RNA	INS	-	-	GT	rs35564666	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:69850399_69850400insGT	ENST00000534086.1	+	0	291																											CATGAGAGAGAGTGTGTGCAAA	0.416													4	3	---	---	---	---					
DISC1FP1	101929222	broad.mit.edu	37	11	90276147	90276152	+	RNA	DEL	ACACAC	ACACAC	-	rs141870455		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:90276147_90276152delACACAC	ENST00000562678.1	+	0	43																											acacacacatacacacacacacacac	0.379													2	4	---	---	---	---					
LINC00900	283143	broad.mit.edu	37	11	115629691	115629692	+	RNA	INS	-	-	G			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:115629691_115629692insG	ENST00000499809.1	-	0	165				AP000797.3_ENST00000539305.1_lincRNA	NR_034148.1																						GTGGGGGTGGCGGGGGGAGTCA	0.470													2	4	---	---	---	---					
AP002954.4	0	broad.mit.edu	37	11	118611796	118611796	+	RNA	DEL	G	G	-	rs139990841		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr11:118611796delG	ENST00000526274.1	+	0	374																											agcctacctagttgttgtcat	0.398													7	0	---	---	---	---					
LINC00940	100271702	broad.mit.edu	37	12	2039083	2039084	+	RNA	DEL	AG	AG	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:2039083_2039084delAG	ENST00000418006.1	-	0	1633_1634					NR_036546.1																						gggaggagtaagagggggagga	0.619													6	0	---	---	---	---					
LOC100506314	100506314	broad.mit.edu	37	12	13105021	13105022	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:13105021_13105022insC	ENST00000543515.2	+	0	46				RP11-392P7.6_ENST00000394742.3_RNA|RP11-392P7.6_ENST00000536029.1_RNA|RP11-392P7.6_ENST00000545914.1_RNA|RP11-392P7.6_ENST00000540198.1_RNA|RP11-392P7.6_ENST00000542078.1_RNA																							TGAGAACATGGCCCCCCAATTC	0.470													2	4	---	---	---	---					
RP11-153K16.2	0	broad.mit.edu	37	12	23401563	23401564	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:23401563_23401564insA	ENST00000538297.1	-	0	39																											CTAAATTCCCTAAAAATGTTCC	0.312													2	4	---	---	---	---					
DDX11-AS1	100506660	broad.mit.edu	37	12	31212218	31212219	+	RNA	DEL	AG	AG	-	rs67354211		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:31212218_31212219delAG	ENST00000500527.1	-	0	764				DDX11-AS1_ENST00000535870.1_RNA	NR_038927.1																						gtgtctaaaaagagagagagaa	0.446													3	4	---	---	---	---					
RP11-478B9.1	0	broad.mit.edu	37	12	45492497	45492498	+	RNA	INS	-	-	A	rs11397583		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:45492497_45492498insA	ENST00000548424.1	+	0	448																											AAATTCTTACCAAAAAAAAAAA	0.356													6	2	---	---	---	---					
RP11-324P9.1	0	broad.mit.edu	37	12	69606408	69606411	+	RNA	DEL	TTTG	TTTG	-	rs10591195		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:69606408_69606411delTTTG	ENST00000548266.1	+	0	296																											ATTGTGGGGttttgtttgtttgtt	0.422													2	4	---	---	---	---					
RP11-175P13.3	0	broad.mit.edu	37	12	100582504	100582505	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:100582504_100582505insA	ENST00000548404.2	-	0	197																											GGTTCCCAGTCAAAAAAGTGAA	0.391													2	4	---	---	---	---					
CASC18	101929110	broad.mit.edu	37	12	106122231	106122232	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:106122231_106122232insT	ENST00000548557.1	+	0	54																											TCTCTCCCTTATTTTTAGGCAA	0.416													2	4	---	---	---	---					
RP11-1028N23.4	0	broad.mit.edu	37	12	116030327	116030327	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:116030327delT	ENST00000551940.1	-	0	343																											ctccattttcTTTTTTTTTTT	0.473													2	4	---	---	---	---					
ZNF140	7699	broad.mit.edu	37	12	133683010	133683010	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr12:133683010delA	ENST00000355557.2	+	5	2430	c.1147delA	c.(1147-1149)aafs	p.K383fs	ZNF140_ENST00000440550.2_3'UTR|ZNF140_ENST00000544426.1_Frame_Shift_Del_p.K280fs	NM_003440.2	NP_003431.2	P52738	ZN140_HUMAN	zinc finger protein 140	383						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.114)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CACTGGAGAGAAACCCTATGC	0.418													15	102	---	---	---	---					
LINC00539	100652865	broad.mit.edu	37	13	21895825	21895825	+	RNA	DEL	A	A	-	rs34375679		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:21895825delA	ENST00000434601.2	-	0	473					NR_103840.1																						TGTGCCCAGCAAAAAAAaaaa	0.478													2	4	---	---	---	---					
RP11-124N19.3	0	broad.mit.edu	37	13	23493872	23493873	+	RNA	DEL	TG	TG	-	rs36047826		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:23493872_23493873delTG	ENST00000575845.1	+	0	86																											agtattccactgtgtgtgtgtg	0.401													2	4	---	---	---	---					
TUSC8	400128	broad.mit.edu	37	13	44978228	44978243	+	RNA	DEL	TCTCTCTGTGTCTGTT	TCTCTCTGTGTCTGTT	-	rs113764468	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:44978228_44978243delTCTCTCTGTGTCTGTT	ENST00000432701.2	-	0	272																											tccgtctctgtctctctgtgtctgtttctctctgtc	0.449													3	5	---	---	---	---					
LINC00348	100885781	broad.mit.edu	37	13	71607469	71607470	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:71607469_71607470insC	ENST00000428761.1	+	0	108					NR_047699.1																						ggccccaatcaccccccacttg	0.574													3	3	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	78615095	78615096	+	RNA	DEL	AC	AC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:78615095_78615096delAC	ENST00000607862.1	+	0	230																											GCCCCCTGAAACACACACACAC	0.347													3	6	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	78924032	78924032	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:78924032delA	ENST00000607862.1	+	0	315				RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000606187.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000606803.1_RNA|RNF219-AS1_ENST00000605996.1_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000606124.1_RNA																							TGTAGGAAGGAAAAAAAAAGG	0.358													2	4	---	---	---	---					
MIR4500HG	642345	broad.mit.edu	37	13	88193466	88193469	+	RNA	DEL	TAGC	TAGC	-	rs137905877		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr13:88193466_88193469delTAGC	ENST00000436290.2	-	0	128					NR_033829.1																						CACCTTAAAGTAGCTAGCTGCATC	0.431													3	5	---	---	---	---					
LINC00596	414767	broad.mit.edu	37	14	24401061	24401061	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:24401061delC	ENST00000559615.1	-	0	597																											cgaaaccagtccctggtgcca	0.413													2	4	---	---	---	---					
RP11-562L8.1	0	broad.mit.edu	37	14	29748371	29748371	+	RNA	DEL	G	G	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:29748371delG	ENST00000551040.1	-	0	364																											gtggagtggtggggaaaaaag	0.388													2	4	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38533598	38533598	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:38533598delT	ENST00000554687.1	-	0	200				CTD-2058B24.2_ENST00000555342.1_RNA																							GTCAtttttgttttttgtaga	0.348													2	4	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57512940	57512941	+	RNA	INS	-	-	G	rs10543554		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:57512940_57512941insG	ENST00000554725.1	+	0	344																											ACAAAAAAAAAAAagagagaga	0.411													2	4	---	---	---	---					
RP11-1152H15.1	0	broad.mit.edu	37	14	88294256	88294256	+	RNA	DEL	T	T	-	rs78846978		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:88294256delT	ENST00000554305.1	-	0	110				RP11-804L24.2_ENST00000555913.1_lincRNA																							tatcaagtgcttttttctgta	0.373													4	3	---	---	---	---					
GALC	2581	broad.mit.edu	37	14	88321105	88321106	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr14:88321105_88321106insA	ENST00000554305.1	-	0	17																											gactccgtctcaaaaaaacaaa	0.470													2	4	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61697243	61697244	+	RNA	DEL	TG	TG	-	rs71859525		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:61697243_61697244delTG	ENST00000559783.1	-	0	186																											tatgtgtgtttgtgtgtgtgtg	0.406													3	4	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	88132231	88132232	+	RNA	DEL	TC	TC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:88132231_88132232delTC	ENST00000560439.1	-	0	80																											tgaTACTGAGTCTCTGTCTTAT	0.475													4	3	---	---	---	---					
CRTC3-AS1	101926895	broad.mit.edu	37	15	91217734	91217735	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:91217734_91217735insT	ENST00000559531.1	-	0	294																											CAACATACttcttttttttttt	0.396													3	4	---	---	---	---					
CRTC3-AS1	101926895	broad.mit.edu	37	15	91245348	91245349	+	RNA	DEL	GT	GT	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:91245348_91245349delGT	ENST00000559531.1	-	0	294																											gtgtgtgcgcgtgtgtgtgtgC	0.480													2	4	---	---	---	---					
LINC01579	283682	broad.mit.edu	37	15	94398352	94398352	+	RNA	DEL	T	T	-	rs10574706		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:94398352delT	ENST00000557481.2	-	0	430																											ACTAAGCATCTTTTTTTTTTT	0.244													2	4	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94577628	94577628	+	RNA	DEL	T	T	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr15:94577628delT	ENST00000558874.1	-	0	1141																											CAGTGTTAACTTTTTTTTTTC	0.348													2	4	---	---	---	---					
LOC101927009	101927009	broad.mit.edu	37	16	9499634	9499635	+	RNA	INS	-	-	ATAC	rs140181290	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:9499634_9499635insATAC	ENST00000564305.1	+	0	2982_2983																											CAGTTacacatacacacacatg	0.381													6	3	---	---	---	---					
CES1P1	51716	broad.mit.edu	37	16	55802360	55802361	+	RNA	INS	-	-	TCAT	rs113112373	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:55802360_55802361insTCAT	ENST00000571348.1	+	0	448					NR_003276.2																						GAAACGtttactcattcattca	0.460													4	5	---	---	---	---					
LINC00922	283867	broad.mit.edu	37	16	65526534	65526535	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:65526534_65526535insA	ENST00000569736.1	-	0	217					NR_027755.1																						ACACATTCACTAAAAAAACAAT	0.416													2	4	---	---	---	---					
LOC100996425	100996425	broad.mit.edu	37	16	80924722	80924723	+	RNA	INS	-	-	T	rs66490638	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:80924722_80924723insT	ENST00000562231.1	-	0	91																											tcaaataaatagcatatacata	0.297													4	4	---	---	---	---					
AC137934.1	0	broad.mit.edu	37	16	90279596	90279597	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr16:90279596_90279597insA	ENST00000568418.1	+	0	263																											aaaacaaaaacaaaaaaaCCGG	0.475													3	5	---	---	---	---					
TBC1D3P3	653017	broad.mit.edu	37	17	20451429	20451430	+	RNA	INS	-	-	C	rs74830149		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:20451429_20451430insC	ENST00000591705.1	+	0	2746_2747																											CATCCCCCCCACCCCCCCAGGC	0.579													2	4	---	---	---	---					
SUZ12P1	440423	broad.mit.edu	37	17	29086616	29086616	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:29086616delA	ENST00000582557.1	+	0	1064																											TTGTGAATGTAAAAAAAAAGT	0.299													2	4	---	---	---	---					
LOC102723505	102723505	broad.mit.edu	37	17	70018181	70018182	+	RNA	DEL	AA	AA	-	rs60415916		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:70018181_70018182delAA	ENST00000430908.2	-	0	217																											CTTTGGAAGGAAAAAAAAAAAA	0.307													2	4	---	---	---	---					
LOC100507351	100507351	broad.mit.edu	37	17	75554356	75554357	+	RNA	INS	-	-	C			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr17:75554356_75554357insC	ENST00000591283.1	+	0	133_134																											GTCCCCCAGCGCCCCCCGAGCA	0.624													2	4	---	---	---	---					
RP11-78F17.1	0	broad.mit.edu	37	18	1035683	1035684	+	RNA	DEL	AC	AC	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:1035683_1035684delAC	ENST00000580781.1	+	0	306																											ACATTACACTacacacacacac	0.312													2	4	---	---	---	---					
RP11-78F17.1	0	broad.mit.edu	37	18	1055724	1055725	+	RNA	INS	-	-	T	rs141839360	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:1055724_1055725insT	ENST00000580781.1	+	0	306																											tactcatttaattttttttttg	0.307													6	7	---	---	---	---					
CTD-2015H3.2	0	broad.mit.edu	37	18	1695641	1695642	+	RNA	INS	-	-	TTG	rs57195893	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:1695641_1695642insTTG	ENST00000580524.1	+	0	408																											tatctttgattttgttgttgtt	0.416													9	6	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22354358	22354359	+	RNA	DEL	AT	AT	-	rs145097040		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:22354358_22354359delAT	ENST00000582650.1	+	0	235																											tgggacctgcatatcatgcaga	0.515													4	2	---	---	---	---					
LOC284294	284294	broad.mit.edu	37	18	61994127	61994128	+	RNA	INS	-	-	AC	rs138807207	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr18:61994127_61994128insAC	ENST00000589376.1	+	0	580					NR_033881.1																						TTTTCAAAATTacacacacaca	0.386													2	4	---	---	---	---					
AC005780.1	0	broad.mit.edu	37	19	28837579	28837580	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:28837579_28837580insT	ENST00000592311.1	-	0	250																											AGTCAGCAGAATTTTGCTCAGC	0.436													2	4	---	---	---	---					
SPACA6P	147650	broad.mit.edu	37	19	52197986	52197987	+	RNA	INS	-	-	T	rs140038491	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr19:52197986_52197987insT	ENST00000573266.1	+	0	1212					NR_024330.1																						GAAGGCAGCTCTAAGAGCCAGG	0.584													4	5	---	---	---	---					
RP4-764O22.1	0	broad.mit.edu	37	20	7096539	7096540	+	RNA	INS	-	-	T			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:7096539_7096540insT	ENST00000425900.1	+	0	81																											TTTTCATCCCATTTTTTTTGCT	0.381													2	4	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29591330	29591330	+	RNA	DEL	G	G	-	rs111496948		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:29591330delG	ENST00000432067.1	-	0	152																											caatggggaaggaaaaagcaa	0.448													3	4	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29593345	29593346	+	RNA	DEL	AG	AG	-	rs113305967		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:29593345_29593346delAG	ENST00000432067.1	-	0	74																											aaattgactaagacaATTGGTG	0.347													4	8	---	---	---	---					
RP5-1121H13.4	0	broad.mit.edu	37	20	40635468	40635469	+	RNA	INS	-	-	A	rs67478321	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:40635468_40635469insA	ENST00000431589.1	+	0	131																											CAAGACAAAATAAAAAAAACAT	0.391													3	6	---	---	---	---					
APCDD1L-AS1	149773	broad.mit.edu	37	20	57168234	57168234	+	RNA	DEL	C	C	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr20:57168234delC	ENST00000427140.1	+	0	943					NR_034147.1																						TAAGGTCCCACCCCCTCCACC	0.522													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11046078	11046079	+	RNA	INS	-	-	AT	rs144620563		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:11046078_11046079insAT	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTAAAAAAAACAAAGTTATTCG	0.262													3	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11055543	11055544	+	RNA	DEL	CA	CA	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:11055543_11055544delCA	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		atatacaaggcacaatcttatg	0.257													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11096543	11096544	+	RNA	DEL	AG	AG	-	rs55694987		TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:11096543_11096544delAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tttttgagacagagtctccctc	0.495													3	6	---	---	---	---					
MIR99AHG	388815	broad.mit.edu	37	21	17548597	17548597	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:17548597delA	ENST00000458468.1	+	0	312					NR_027790.1																						TCTCTTTGCCAACACCTATAT	0.358													2	4	---	---	---	---					
AF131217.1	0	broad.mit.edu	37	21	29849614	29849615	+	RNA	INS	-	-	A			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:29849614_29849615insA	ENST00000433310.1	-	0	456																											TCCAGCATTTTAAAAACTTTTG	0.332													2	4	---	---	---	---					
AF131217.1	0	broad.mit.edu	37	21	29973230	29973231	+	RNA	INS	-	-	T	rs146882239	by1000genomes	TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:29973230_29973231insT	ENST00000433310.1	-	0	294																											ctttattccagtttccaataag	0.381													2	4	---	---	---	---					
AP000282.2	0	broad.mit.edu	37	21	34372341	34372341	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chr21:34372341delA	ENST00000420356.1	-	0	201				AP000282.2_ENST00000454622.1_RNA																							GTAATTTGGGATAGAATCAAC	0.363													2	4	---	---	---	---					
RP13-188A5.1	0	broad.mit.edu	37	X	55989624	55989624	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:55989624delA	ENST00000452532.1	+	0	678																											ATTTAAAAATAAAGAACATAA	0.348													2	4	---	---	---	---					
LINC01278	92249	broad.mit.edu	37	X	62757565	62757565	+	RNA	DEL	A	A	-			TCGA-17-Z003-01A-01W-0746-08	TCGA-17-Z003-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	443d768f-b871-4149-9ef0-2d49bc0d05a1	df1db93e-dd3b-48eb-9d24-8de9a08c4204	g.chrX:62757565delA	ENST00000433061.1	-	0	218																											cagctttgctaaaggacagta	0.537													2	4	---	---	---	---					
