Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC645166	645166	broad.mit.edu	37	1	148951302	148951302	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:148951302G>T	ENST00000539543.1	+	0	312					NR_027355.1																						aatgtgagcagagtgctgcag	0.522000													9	43					3.09899e-07	3.69782e-07	0.047766	1	0
NEB	4703	broad.mit.edu	37	2	152522011	152522011	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:152522011C>T	ENST00000427231.2	-	42	5276	c.5074G>A	c.(5074-5076)Ggc>Agc	p.G1692S	NEB_ENST00000172853.10_Missense_Mutation_p.G1692S|NEB_ENST00000409198.1_Missense_Mutation_p.G1692S|NEB_ENST00000397345.3_Missense_Mutation_p.G1692S|NEB_ENST00000604864.1_Missense_Mutation_p.G1692S|NEB_ENST00000603639.1_Missense_Mutation_p.G1692S	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1692					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGCACCCAGCCGATCCCTTTC	0.443000													8	23					0	0	0.038147	0	0
PAFAH1B1	5048	broad.mit.edu	37	17	2583589	2583589	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:2583589G>T	ENST00000397195.5	+	10	1585	c.1134G>T	c.(1132-1134)gcG>gcT	p.A378A	PAFAH1B1_ENST00000397193.3_3'UTR|PAFAH1B1_ENST00000451360.2_Silent_p.A173A	NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	378	Interaction with DCX.|Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						CCCTCAATGCGCATGAACACT	0.453000													7	55					0.000673444	0.000737108	0.069234	1	0
DHCR24	1718	broad.mit.edu	37	1	55319744	55319744	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:55319744T>G	ENST00000371269.3	-	7	1282	c.1184A>C	c.(1183-1185)cAg>cCg	p.Q395P	DHCR24_ENST00000537443.1_Missense_Mutation_p.Q179P|DHCR24_ENST00000535035.1_Missense_Mutation_p.Q354P	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	395					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						CAGGGCCTGCTGCAGGCACTT	0.617000													11	29					0	0	0.020292	0	0
TNKS2	80351	broad.mit.edu	37	10	93611069	93611069	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:93611069G>C	ENST00000371627.4	+	21	3170	c.2791G>C	c.(2791-2793)Gag>Cag	p.E931Q		NM_025235.3	NP_079511.1	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	931	SAM.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				TAAAGGAGTCGAGAGACTTAT	0.368000													17	67					0	0	0.049695	0	0
COL4A5	1287	broad.mit.edu	37	X	107930822	107930822	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:107930822A>G	ENST00000328300.6	+	49	4670	c.4426A>G	c.(4426-4428)Aca>Gca	p.T1476A	COL4A5_ENST00000361603.2_Missense_Mutation_p.T1470A	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1470	Collagen IV NC1.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CCACAGCCAGACAACGGATGC	0.512000									Alport syndrome with Diffuse Leiomyomatosis				132	173					0	0	0.048971	0	0
SLC13A5	284111	broad.mit.edu	37	17	6610463	6610463	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:6610463C>G	ENST00000433363.2	-	2	348	c.115G>C	c.(115-117)Gcc>Ccc	p.A39P	SLC13A5_ENST00000293800.6_Missense_Mutation_p.A39P|SLC13A5_ENST00000573648.1_Missense_Mutation_p.A39P|SLC13A5_ENST00000381074.4_Intron	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	39						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						ATGACGTAGGCACACCTGACA	0.567000													30	13					0	0	0.045705	0	0
FRAS1	80144	broad.mit.edu	37	4	79417957	79417957	+	Splice_Site	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:79417957A>T	ENST00000264895.6	+	60	9398		c.e60-1			NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1						cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CATTGGCTCTAGGTGAAGAAC	0.418000													130	88					0	0	0.048971	0	0
TGM5	9333	broad.mit.edu	37	15	43526973	43526973	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:43526973C>T	ENST00000220420.5	-	11	1876	c.1869G>A	c.(1867-1869)acG>acA	p.T623T	TGM5_ENST00000349114.4_Silent_p.T541T	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	623					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CTACATTAATCGTGATGCTTG	0.542000													17	32					0	0	0.049695	0	0
TMEM31	203562	broad.mit.edu	37	X	102968777	102968777	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:102968777G>A	ENST00000319560.6	+	3	549	c.358G>A	c.(358-360)Gga>Aga	p.G120R	GLRA4_ENST00000372617.4_Intron	NM_182541.2	NP_872347.2	Q5JXX7	TMM31_HUMAN	transmembrane protein 31	120						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)	7						GGAAAAGATCGGACTGCCCAT	0.413000													167	456					0	0	0.048971	0	0
KCNJ10	3766	broad.mit.edu	37	1	160012018	160012018	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:160012018G>C	ENST00000368089.3	-	2	531	c.305C>G	c.(304-306)cCg>cGg	p.P102R	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	102						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGGTTGGCCGGGGGGTCCAG	0.587000													108	162					0	0	0.048971	0	0
MUC16	94025	broad.mit.edu	37	19	9074641	9074641	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:9074641A>G	ENST00000397910.4	-	3	13008	c.12805T>C	c.(12805-12807)Tcc>Ccc	p.S4269P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4271	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGCTTTGGATGGCTTTGTA	0.473000													12	166					0	0	0.105934	0	0
SH3TC2	79628	broad.mit.edu	37	5	148421175	148421175	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:148421175A>T	ENST00000515425.1	-	6	636	c.535T>A	c.(535-537)Ttc>Atc	p.F179I	SH3TC2_ENST00000512049.1_Missense_Mutation_p.F172I|SH3TC2_ENST00000394358.2_Missense_Mutation_p.F64I	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	179							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCAGAAGAAGTGGCCTGTG	0.463000													9	43					0	0	0.047766	0	0
NRXN1	9378	broad.mit.edu	37	2	50280583	50280583	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:50280583G>T	ENST00000404971.1	-	22	5413	c.4074C>A	c.(4072-4074)atC>atA	p.I1358I	NRXN1_ENST00000406316.2_Silent_p.I1288I|NRXN1_ENST00000406859.3_Silent_p.I1288I|NRXN1_ENST00000402717.3_Silent_p.I1310I|NRXN1_ENST00000401710.1_Silent_p.I306I|NRXN1_ENST00000405472.3_Silent_p.I1310I|NRXN1_ENST00000342183.5_Silent_p.I253I|NRXN1_ENST00000401669.2_Silent_p.I1318I	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1288					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCACTATGGCGATGTTGGCAT	0.512000													24	62					2.89027e-11	3.72468e-11	0.069288	1	0
CDH6	1004	broad.mit.edu	37	5	31323217	31323217	+	Silent	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:31323217G>C	ENST00000265071.2	+	12	2440	c.2175G>C	c.(2173-2175)acG>acC	p.T725T		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	725					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AAAATGACACGGACCCCACTG	0.567000													10	59					0	0	0.069234	0	0
RIMBP2	23504	broad.mit.edu	37	12	130941233	130941233	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:130941233C>A	ENST00000261655.4	-	4	278	c.115G>T	c.(115-117)Gag>Tag	p.E39*	RIMBP2_ENST00000536002.1_5'UTR|RIMBP2_ENST00000535703.1_5'UTR	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	39						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCTTCCAGCTCTCGAACCTTG	0.577000													6	13					8.12818e-05	9.07076e-05	0.029380	1	0
OLFM4	10562	broad.mit.edu	37	13	53603065	53603065	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:53603065C>A	ENST00000219022.2	+	1	172	c.94C>A	c.(94-96)Ccc>Acc	p.P32T		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	32	Ser-rich.				cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		AATTCCCAGCCCCGGCTTCAG	0.612000													49	41					1.78197e-24	2.68381e-24	0.048971	1	0
LPCAT2	54947	broad.mit.edu	37	16	55565831	55565831	+	Silent	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:55565831A>T	ENST00000262134.5	+	5	832	c.648A>T	c.(646-648)ctA>ctT	p.L216L		NM_017839.4	NP_060309.2	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	216					cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	12						CCAAGATACTAGTTTTCCCAG	0.299000													9	43					0	0	0.047766	0	0
FCHSD2	9873	broad.mit.edu	37	11	72726866	72726866	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:72726866C>T	ENST00000409314.1	-	4	398	c.230G>A	c.(229-231)cGg>cAg	p.R77Q	FCHSD2_ENST00000311172.7_Missense_Mutation_p.R21Q|FCHSD2_ENST00000458644.2_5'UTR|FCHSD2_ENST00000409853.1_Missense_Mutation_p.R21Q|FCHSD2_ENST00000409418.4_Missense_Mutation_p.R77Q			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	77							protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			GTAATCATTCCGATCATCAGC	0.299000													8	61					0	0	0.069234	0	0
OR2A2	442361	broad.mit.edu	37	7	143807167	143807167	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:143807167G>A	ENST00000408979.2	+	1	561	c.492G>A	c.(490-492)agG>agA	p.R164R		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					TCCTTCTAAGGTTGCCCTTCT	0.532000													21	92					0	0	0.049695	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40839964	40839964	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:40839964C>T	ENST00000264638.4	+	8	1488	c.1271C>T	c.(1270-1272)gCg>gTg	p.A424V	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	424	Laminin G-like 2.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GTGTCCATCGCGCAGAGCGGC	0.607000													4	36					0	0	0.021553	0	0
COBL	23242	broad.mit.edu	37	7	51258706	51258706	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:51258706G>A	ENST00000395542.2	-	4	710	c.526C>T	c.(526-528)Cct>Tct	p.P176S	COBL_ENST00000395540.2_Missense_Mutation_p.P176S|COBL_ENST00000441453.1_Missense_Mutation_p.P176S|COBL_ENST00000265136.7_Missense_Mutation_p.P176S			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	176										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TTCTGGAGAGGAACCTCAGGG	0.507000													14	31					0	0	0.038395	0	0
ANK2	287	broad.mit.edu	37	4	114278824	114278824	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:114278824C>A	ENST00000357077.4	+	38	9103	c.9050C>A	c.(9049-9051)cCt>cAt	p.P3017H	ANK2_ENST00000264366.6_Missense_Mutation_p.P2984H|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2984					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCTTTCGAGCCTACTATGTCC	0.398000													45	287					1.15505e-17	1.64278e-17	0.111260	1	0
MAN2B1	4125	broad.mit.edu	37	19	12760975	12760975	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:12760975A>T	ENST00000456935.2	-	17	2148	c.2108T>A	c.(2107-2109)cTg>cAg	p.L703Q	MAN2B1_ENST00000221363.4_Missense_Mutation_p.L702Q	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	703					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCCTGGGTACAGGCGAACCAC	0.627000													32	32					0	0	0.054565	0	0
TRPC4	7223	broad.mit.edu	37	13	38357119	38357119	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:38357119G>T	ENST00000379705.3	-	2	1209	c.352C>A	c.(352-354)Cac>Aac	p.H118N	TRPC4_ENST00000379673.2_Missense_Mutation_p.H118N|TRPC4_ENST00000426868.2_Missense_Mutation_p.H118N|TRPC4_ENST00000338947.5_Missense_Mutation_p.H118N|TRPC4_ENST00000379681.3_Missense_Mutation_p.H118N|TRPC4_ENST00000379679.1_Missense_Mutation_p.H118N|TRPC4_ENST00000355779.2_Missense_Mutation_p.H118N|TRPC4_ENST00000358477.2_Missense_Mutation_p.H118N|TRPC4_ENST00000447043.1_Missense_Mutation_p.H118N			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	118	Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GGTTTTTTGTGGTTCAATAAC	0.338000													31	32					6.05902e-23	9.03367e-23	0.064281	1	0
C1orf141	400757	broad.mit.edu	37	1	67558976	67558976	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:67558976T>A	ENST00000371007.2	-	8	1024	c.915A>T	c.(913-915)acA>acT	p.T305T	C1orf141_ENST00000371006.1_Silent_p.T305T|C1orf141_ENST00000544837.1_Silent_p.T305T	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	305										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TGTTTTCTAGTGTCTGCTTAT	0.343000													12	38					0	0	0.093190	0	0
B3GAT2	135152	broad.mit.edu	37	6	71571537	71571537	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:71571537G>T	ENST00000230053.6	-	3	1489	c.881C>A	c.(880-882)aCt>aAt	p.T294N	SMAP1_ENST00000370455.3_3'UTR	NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	294					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						GAATACCTTAGTGCAGTTATT	0.478000													18	72					3.32936e-07	3.95361e-07	0.038395	1	0
CAMP	820	broad.mit.edu	37	3	48265844	48265844	+	Splice_Site	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:48265844G>A	ENST00000296435.2	+	2	367	c.210_splice	c.e2-1	p.D71_splice	CAMP_ENST00000576243.1_Splice_Site_p.D68_splice	NM_004345.4	NP_004336.3	P49913	CAMP_HUMAN	cathelicidin antimicrobial peptide	68					killing by host of symbiont cells|negative regulation of growth of symbiont on or near host surface	extracellular region				endometrium(2)|large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000614)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CTCTGACTAGGATGGGGACCC	0.532000													13	8					0	0	0.024245	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159538	242159538	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:242159538G>A	ENST00000357246.3	-	4	435	c.371C>T	c.(370-372)aCa>aTa	p.T124I		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	124					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCAGCCAAATGTCTCCTGGGA	0.567000													36	28					0	0	0.069456	0	0
SLC2A1	6513	broad.mit.edu	37	1	43392885	43392885	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:43392885T>C	ENST00000426263.3	-	10	1484	c.1306A>G	c.(1306-1308)Atc>Gtc	p.I436V	SLC2A1_ENST00000475162.1_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	436					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	ACAGTGAAGATGATGAAGACG	0.498000													4	52					0	0	0.009096	0	0
IGSF1	3547	broad.mit.edu	37	X	130416704	130416704	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:130416704G>A	ENST00000370904.1	-	13	1843	c.933C>T	c.(931-933)ttC>ttT	p.F311F	IGSF1_ENST00000361420.3_Silent_p.F320F|IGSF1_ENST00000370903.3_Silent_p.F320F|IGSF1_ENST00000370910.1_Silent_p.F311F			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	320	Ig-like C2-type 3.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						AGGTCTTGGGGAAAGTGTCTA	0.512000													49	83					0	0	0.048971	0	0
PLK4	10733	broad.mit.edu	37	4	128807079	128807079	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:128807079G>A	ENST00000270861.5	+	5	828	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	PLK4_ENST00000515069.1_Missense_Mutation_p.R185Q|PLK4_ENST00000513090.1_Missense_Mutation_p.R153Q|PLK4_ENST00000514379.1_Missense_Mutation_p.R144Q|PLK4_ENST00000507249.1_Missense_Mutation_p.R185Q	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	185	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						ATTGCCACTCGAAGTGCACAT	0.433000													9	30					0	0	0.058154	0	0
ZNF251	90987	broad.mit.edu	37	8	145947114	145947114	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:145947114C>T	ENST00000292562.7	-	5	2206	c.1931G>A	c.(1930-1932)cGt>cAt	p.R644H	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CTCTCCAACACGAGTCTGCTG	0.403000													11	61					0	0	0.080935	0	0
URGCP	55665	broad.mit.edu	37	7	43916325	43916325	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:43916325C>T	ENST00000336086.6	-	4	4844	c.2608G>A	c.(2608-2610)Ggc>Agc	p.G870S	URGCP_ENST00000223341.7_Missense_Mutation_p.G870S|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000453200.1_Missense_Mutation_p.G913S|URGCP_ENST00000402306.3_Missense_Mutation_p.G904S|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000447717.3_Missense_Mutation_p.G870S|URGCP_ENST00000443736.1_Missense_Mutation_p.G870S			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	913					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TTCGACAAGCCGTTCCTGATG	0.527000													34	47					0	0	0.086207	0	0
KIAA1199	57214	broad.mit.edu	37	15	81171177	81171177	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:81171177C>A	ENST00000394685.3	+	4	629	c.210C>A	c.(208-210)gcC>gcA	p.A70A	KIAA1199_ENST00000220244.3_Silent_p.A70A|KIAA1199_ENST00000356249.5_Silent_p.A70A			Q8WUJ3	K1199_HUMAN	KIAA1199	70	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CCTCTTCTGCCACGGTCTATT	0.572000													22	15					6.07407e-21	8.93033e-21	0.034045	1	0
PLXNA3	55558	broad.mit.edu	37	X	153697726	153697726	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:153697726G>T	ENST00000369682.3	+	27	4774	c.4599G>T	c.(4597-4599)tgG>tgT	p.W1533C	PLXNA3_ENST00000493546.1_3'UTR	NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1533					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCACAGAGTGGCGCCAGGGCC	0.597000													12	5					4.3838e-07	5.18913e-07	0.105934	1	0
SNHG14	104472715	broad.mit.edu	37	15	25485056	25485056	+	RNA	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:25485056C>T	ENST00000453082.2	+	0	1979				SNORD115-38_ENST00000365037.1_RNA	NR_003343.1																						AATAGGATTACGCTGAGGCCC	0.512000													19	47					0	0	0.055883	0	0
WIPF3	644150	broad.mit.edu	37	7	29943995	29943995	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:29943995G>T	ENST00000409123.1	+	8	1695	c.1445G>T	c.(1444-1446)tGt>tTt	p.C482F	WIPF3_ENST00000242140.5_Missense_Mutation_p.C482F|WIPF3_ENST00000409290.1_Intron			B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	0										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						CAAGCCTCATGTCTCTGAATG	0.478000													69	104					4.14589e-37	6.69305e-37	0.048971	1	0
HLTF	6596	broad.mit.edu	37	3	148764045	148764045	+	Splice_Site	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:148764045G>A	ENST00000310053.5	-	18	2087	c.1892_splice	c.e18-1	p.R632_splice	HLTF_ENST00000494055.1_Splice_Site_p.R632_splice|HLTF_ENST00000392912.2_Splice_Site_p.R632_splice|HLTF_ENST00000465259.1_Splice_Site_p.R631_splice	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	632					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GACTGTAAACGCCTAATCAGA	0.259000													3	7					0	0	0.009096	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481804	142481804	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:142481804G>T	ENST00000603901.1	+	0	483					NR_001296.3																						TGCAGTGCCTGGACGCTCCTG	0.502000													76	150					4.02937e-33	6.36623e-33	0.048971	1	0
ACOT6	641372	broad.mit.edu	37	14	74083897	74083897	+	Splice_Site	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:74083897G>C	ENST00000381139.1	+	1	349		c.e1+1		RP3-414A15.10_ENST00000555011.1_RNA	NM_001037162.1	NP_001032239.1	Q3I5F7	ACOT6_HUMAN	acyl-CoA thioesterase 6							cytosol	carboxylesterase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00331)		GCATCCAAAGGTGCGTTCTGG	0.488000													26	46					0	0	0.041601	0	0
TMEM132E	124842	broad.mit.edu	37	17	32959924	32959924	+	Missense_Mutation	SNP	C	C	G	rs148901847	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:32959924C>G	ENST00000321639.5	+	7	1742	c.1414C>G	c.(1414-1416)Cgg>Ggg	p.R472G		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	472						integral to membrane		p.R472W(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCTCCCCGACCGGAGGTACAG	0.587000													26	38					0	0	0.034045	0	0
FCRL6	343413	broad.mit.edu	37	1	159779445	159779445	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:159779445G>C	ENST00000321935.6	+	6	965	c.879G>C	c.(877-879)agG>agC	p.R293S	FCRL6_ENST00000392235.3_Missense_Mutation_p.R191S|FCRL6_ENST00000368106.3_Missense_Mutation_p.R286S|FCRL6_ENST00000339348.5_Missense_Mutation_p.R286S			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	286	Ig-like C2-type 3.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					CCAGAGAGAGGAGTGAGCCCA	0.557000													87	138					0	0	0.048971	0	0
FAM135A	57579	broad.mit.edu	37	6	71269450	71269450	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:71269450G>T	ENST00000418814.2	+	22	4988	c.4374G>T	c.(4372-4374)ttG>ttT	p.L1458F	FAM135A_ENST00000361499.3_Missense_Mutation_p.L1262F|FAM135A_ENST00000370479.3_Missense_Mutation_p.L1245F|FAM135A_ENST00000457062.2_Missense_Mutation_p.L1245F|FAM135A_ENST00000505769.1_Missense_Mutation_p.L1038F	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	1458										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						TCCACAACTTGCTTCGACCCG	0.383000													11	8					5.50884e-06	6.32876e-06	0.093190	1	0
CAV3	859	broad.mit.edu	37	3	8787364	8787364	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:8787364C>A	ENST00000343849.2	+	2	344	c.267C>A	c.(265-267)ggC>ggA	p.G89G	CAV3_ENST00000472766.1_Intron|CAV3_ENST00000397368.2_Silent_p.G89G	NM_001234.4|NM_033337.2	NP_001225.1|NP_203123.1	P56539	CAV3_HUMAN	caveolin 3	89	Required for interaction with DAG1.				cell growth|elevation of cytosolic calcium ion concentration|muscle organ development|negative regulation of cardiac muscle hypertrophy|negative regulation of cell size|negative regulation of MAP kinase activity|negative regulation of sarcomere organization|positive regulation of microtubule polymerization|regulation of skeletal muscle contraction|regulation of ventricular cardiomyocyte membrane repolarization|T-tubule organization	caveola|dystrophin-associated glycoprotein complex|Golgi membrane|neuromuscular junction|T-tubule	protein C-terminus binding|protein complex binding|protein complex scaffold|sodium channel regulator activity			breast(1)|kidney(2)|large_intestine(4)|lung(3)|prostate(1)	11						TGCTCTGGGGCTTCCTGTTCG	0.582000													11	7					3.03607e-14	4.10535e-14	0.093190	1	0
FAM149A	25854	broad.mit.edu	37	4	187075718	187075718	+	Silent	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:187075718T>G	ENST00000356371.5	+	6	1182	c.1182T>G	c.(1180-1182)cgT>cgG	p.R394R	FAM149A_ENST00000227065.4_Silent_p.R103R|FAM149A_ENST00000389354.5_Silent_p.R103R|FAM149A_ENST00000503432.1_Silent_p.R103R|FAM149A_ENST00000514829.1_3'UTR|FAM149A_ENST00000514153.1_Silent_p.R103R|FAM149A_ENST00000502970.1_Silent_p.R103R			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	394										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TAACGGCACGTTCATCCCTGG	0.468000													4	45					0	0	0.009096	0	0
LOC100505664	100505664	broad.mit.edu	37	20	23170443	23170443	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:23170443C>A	ENST00000411595.1	+	0	55																											CAGAGTATGCCCACGCTGGTT	0.557000													2	1					0.0784	0.0801302	0.004672	1	0
AOC1	26	broad.mit.edu	37	7	150554366	150554366	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:150554366G>T	ENST00000493429.1	+	4	1392	c.808G>T	c.(808-810)Ggc>Tgc	p.G270C	AOC1_ENST00000467291.1_Missense_Mutation_p.G270C|AOC1_ENST00000416793.2_Missense_Mutation_p.G270C|AOC1_ENST00000360937.4_Missense_Mutation_p.G270C					amine oxidase, copper containing 1																		GCTGCCTGGGGGCAAGGGGCA	0.652000													12	13					0.00185496	0.00198918	0.105934	1	0
SLC6A19	340024	broad.mit.edu	37	5	1216785	1216785	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:1216785G>A	ENST00000304460.10	+	7	1056	c.1000G>A	c.(1000-1002)Gac>Aac	p.D334N		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	334					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACAGCGCTACGACGACTGCTT	0.622000													4	19					0	0	0.014758	0	0
PNMA5	114824	broad.mit.edu	37	X	152160070	152160070	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:152160070C>T	ENST00000439251.1	-	2	511	c.73G>A	c.(73-75)Ggc>Agc	p.G25S	PNMA5_ENST00000361887.5_Missense_Mutation_p.G25S|PNMA5_ENST00000452693.1_Missense_Mutation_p.G25S|PNMA5_ENST00000535214.1_Missense_Mutation_p.G25S	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	25					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					atggggatgcctacaatcagc	0.532000													11	289					0	0	0.093190	0	0
GTSE1	51512	broad.mit.edu	37	22	46704789	46704789	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:46704789G>T	ENST00000454366.1	+	4	923	c.711G>T	c.(709-711)ctG>ctT	p.L237L		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	218					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AATTGCTGCTGCCTCGAGCGG	0.622000													5	19					3.59834e-05	4.0584e-05	0.021553	1	0
FABP12	646486	broad.mit.edu	37	8	82441714	82441714	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:82441714C>G	ENST00000360464.4	-	2	267	c.205G>C	c.(205-207)Gaa>Caa	p.E69Q	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	69							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						TCAAACTCTTCTCCCAGCTTA	0.403000													36	119					0	0	0.080422	0	0
BMP6	654	broad.mit.edu	37	6	7862664	7862664	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:7862664G>T	ENST00000283147.6	+	4	1296	c.1137G>T	c.(1135-1137)cgG>cgT	p.R379R		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	379					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					CCTCCAGCCGGCGCCGACAAC	0.607000													11	21					0.010729	0.0111817	0.080935	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767626	77767626	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:77767626G>T	ENST00000521891.2	+	10	8917	c.8469G>T	c.(8467-8469)atG>atT	p.M2823I	ZFHX4_ENST00000455469.2_Missense_Mutation_p.M2778I|ZFHX4_ENST00000518282.1_Missense_Mutation_p.M2797I|ZFHX4_ENST00000050961.6_Missense_Mutation_p.M2778I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2778						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACACTGAAATGGAAAGCACCA	0.473000										HNSCC(33;0.089)			51	71					9.52127e-25	1.43692e-24	0.048971	1	0
PILRB	29990	broad.mit.edu	37	7	99950619	99950619	+	Splice_Site	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:99950619G>T	ENST00000310771.4	+	10	1353		c.e10-1		PILRB_ENST00000452089.1_Splice_Site|PILRB_ENST00000448382.1_5'UTR|PILRB_ENST00000444874.1_Splice_Site			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta						activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTGTGCCCAGGGCTCTCTGT	0.667000													6	10					2.0095e-06	2.34125e-06	0.029380	1	0
CSN3	1448	broad.mit.edu	37	4	71114782	71114782	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:71114782C>A	ENST00000304954.3	+	4	241	c.155C>A	c.(154-156)cCa>cAa	p.P52Q		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	52						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						TATTATGTGCCAAATAGCTAT	0.343000													39	75					9.9998e-32	1.57656e-31	0.042209	1	0
TRPM8	79054	broad.mit.edu	37	2	234873364	234873364	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:234873364C>T	ENST00000324695.4	+	14	1882	c.1842C>T	c.(1840-1842)tcC>tcT	p.S614S	TRPM8_ENST00000433712.2_Silent_p.S302S	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	614						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTGGGGAGTCCGAGGAGCTGG	0.577000													10	26					0	0	0.058154	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855647	12855647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:12855647C>A	ENST00000332296.7	+	4	1030	c.927C>A	c.(925-927)gaC>gaA	p.D309E	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.D64E	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	309										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGGAAGAAGACATGAAGTGTC	0.498000													40	86					6.14515e-18	8.79065e-18	0.048971	1	0
MTA3	57504	broad.mit.edu	37	2	42883408	42883408	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:42883408G>T	ENST00000405592.1	+	8	1070	c.400G>T	c.(400-402)Gat>Tat	p.D134Y	MTA3_ENST00000406652.1_Missense_Mutation_p.D134Y|MTA3_ENST00000407270.3_Missense_Mutation_p.D190Y|MTA3_ENST00000406911.1_Missense_Mutation_p.D190Y|MTA3_ENST00000405094.1_Missense_Mutation_p.D190Y			Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	190	BAH.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(9)|ovary(2)|stomach(1)	15						CCCACTTACGGATCGACAGAT	0.333000													38	54					4.01765e-15	5.50292e-15	0.111260	1	0
LTBP1	4052	broad.mit.edu	37	2	33482545	33482545	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:33482545C>G	ENST00000404816.2	+	12	2715	c.2362C>G	c.(2362-2364)Cgg>Ggg	p.R788G	LTBP1_ENST00000354476.3_Missense_Mutation_p.R788G|LTBP1_ENST00000402934.1_Missense_Mutation_p.R409G|LTBP1_ENST00000418533.2_Missense_Mutation_p.R462G|LTBP1_ENST00000390003.4_Missense_Mutation_p.R462G|LTBP1_ENST00000407925.1_Missense_Mutation_p.R462G|LTBP1_ENST00000404525.1_Missense_Mutation_p.R409G			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	788					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GACCTTCTCCCGGGAACACGG	0.517000													4	22					0	0	0.014758	0	0
SIRPA	140885	broad.mit.edu	37	20	1902071	1902071	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:1902071C>A	ENST00000358771.4	+	3	619	c.467C>A	c.(466-468)cCt>cAt	p.P156H	SIRPA_ENST00000356025.3_Missense_Mutation_p.P156H|SIRPA_ENST00000400068.3_Missense_Mutation_p.P156H	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	156	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GTATCGGGCCCTGCGGCGAGG	0.532000													4	22					1.06961e-07	1.28875e-07	0.038147	1	0
OR10J1	26476	broad.mit.edu	37	1	159410295	159410295	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:159410295C>T	ENST00000423932.3	+	1	784	c.747C>T	c.(745-747)gcC>gcT	p.A249A	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	249					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					AGGCTTTTGCCACCTGTGCAT	0.483000													34	64					0	0	0.059317	0	0
DENND2A	27147	broad.mit.edu	37	7	140223132	140223132	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:140223132G>A	ENST00000275884.6	-	16	3057	c.2640C>T	c.(2638-2640)gaC>gaT	p.D880D	DENND2A_ENST00000496613.1_Silent_p.D880D|DENND2A_ENST00000537639.1_Silent_p.D880D			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	880										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					GGGGCCCTTCGTCCTGCTCAC	0.592000													4	20					0	0	0.014758	0	0
TOX	9760	broad.mit.edu	37	8	59764213	59764213	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:59764213C>T	ENST00000361421.1	-	4	783	c.563G>A	c.(562-564)aGt>aAt	p.S188N		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	188						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				AAGTTGAGCACTTAGCTGTGA	0.527000													62	59					0	0	0.048971	0	0
GLDC	2731	broad.mit.edu	37	9	6556186	6556186	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:6556186C>A	ENST00000321612.6	-	18	2319	c.2169G>T	c.(2167-2169)caG>caT	p.Q723H		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	723					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CTAGGTAGACCTGTCCTCCAT	0.453000													20	12					1.64113e-05	1.86515e-05	0.055883	1	0
PLB1	151056	broad.mit.edu	37	2	28804980	28804980	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:28804980C>A	ENST00000327757.5	+	24	1656	c.1612C>A	c.(1612-1614)Ctg>Atg	p.L538M	PLB1_ENST00000329020.6_Missense_Mutation_p.L226M|PLB1_ENST00000422425.2_Intron	NM_153021.4	NP_694566.4	Q6P1J6	PLB1_HUMAN	phospholipase B1	538	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TGGAAAGGCCCTGGACATCCT	0.527000													38	43					2.54651e-27	3.90675e-27	0.092188	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102502947	102502947	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:102502947G>T	ENST00000360184.4	+	57	11040	c.10876G>T	c.(10876-10878)Gca>Tca	p.A3626S	RP11-1017G21.4_ENST00000557551.1_RNA|DYNC1H1_ENST00000556791.1_3'UTR	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3626	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTTAGAGAGTGCACTGAGATT	0.463000													37	53					6.4771e-29	1.0083e-28	0.039052	1	0
NEB	4703	broad.mit.edu	37	2	152541305	152541305	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:152541305G>A	ENST00000427231.2	-	28	3024	c.2822C>T	c.(2821-2823)gCg>gTg	p.A941V	NEB_ENST00000172853.10_Missense_Mutation_p.A941V|NEB_ENST00000409198.1_Missense_Mutation_p.A941V|NEB_ENST00000397345.3_Missense_Mutation_p.A941V|NEB_ENST00000604864.1_Missense_Mutation_p.A941V|NEB_ENST00000603639.1_Missense_Mutation_p.A941V	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	941					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCTCTGCAGCGCATATGCCTT	0.453000													18	83					0	0	0.055883	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304000	151304000	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:151304000G>T	ENST00000370323.4	-	4	409	c.93C>A	c.(91-93)ccC>ccA	p.P31P	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Silent_p.P31P	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	31										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCACAGCCAGGGGAGCCTGTG	0.562000													73	33					3.04226e-33	4.82723e-33	0.048971	1	0
OR2C3	81472	broad.mit.edu	37	1	247695256	247695256	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:247695256C>T	ENST00000366487.3	-	2	919	c.558G>A	c.(556-558)atG>atA	p.M186I	GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366490.3_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AAGCCAGTTGCATAATGAGGG	0.542000													4	16					0	0	0.014758	0	0
OR4M1	441670	broad.mit.edu	37	14	20248771	20248771	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:20248771G>A	ENST00000315957.4	+	1	371	c.290G>A	c.(289-291)tGc>tAc	p.C97Y		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTGGTGGATGCATTGCACAG	0.473000													102	254					0	0	0.048971	0	0
LGR6	59352	broad.mit.edu	37	1	202288055	202288055	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:202288055A>T	ENST00000367278.3	+	18	2713	c.2624A>T	c.(2623-2625)gAt>gTt	p.D875V	LGR6_ENST00000255432.7_Missense_Mutation_p.D823V|LGR6_ENST00000439764.2_Missense_Mutation_p.D736V	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	875						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						GCCTTCTCTGATGTGGATCTC	0.642000													10	54					0	0	0.058154	0	0
CHRM3	1131	broad.mit.edu	37	1	240072406	240072406	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:240072406G>T	ENST00000255380.4	+	5	2434	c.1655G>T	c.(1654-1656)aGa>aTa	p.R552I		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	552					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	AAAACATTCAGAACCACTTTC	0.498000													16	54					4.7546e-09	5.88174e-09	0.028581	1	0
SPATA31A6	389730	broad.mit.edu	37	9	43626715	43626715	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:43626715G>T	ENST00000332857.6	-	4	2000	c.1972C>A	c.(1972-1974)Cag>Aag	p.Q658K		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CTCTCTAGCTGGAACTTCACC	0.562000													31	87					7.7325e-45	1.26765e-44	0.048971	1	0
AHNAK	79026	broad.mit.edu	37	11	62297923	62297923	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:62297923C>G	ENST00000378024.4	-	5	4240	c.3966G>C	c.(3964-3966)aaG>aaC	p.K1322N	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1322					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GCATGGAGATCTTGGGGGCCT	0.517000													50	87					0	0	0.048971	0	0
RALGPS2	55103	broad.mit.edu	37	1	178753642	178753642	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:178753642A>G	ENST00000367635.3	+	3	485	c.147A>G	c.(145-147)acA>acG	p.T49T	RALGPS2_ENST00000367634.2_Silent_p.T49T|RALGPS2_ENST00000324778.4_Intron	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	49	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TTAAGGTTACACCAGAAGAAT	0.393000													16	34					0	0	0.033300	0	0
TEX11	56159	broad.mit.edu	37	X	69849461	69849461	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:69849461C>A	ENST00000395889.2	-	19	1808	c.1653_splice	c.e19+1	p.E551_splice	TEX11_ENST00000374320.2_Splice_Site_p.E226_splice|TEX11_ENST00000344304.3_Splice_Site_p.E551_splice|TEX11_ENST00000374333.2_Splice_Site_p.E536_splice	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	551							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TATGAATTACCTCTAGAGCAA	0.338000													5	149					0.0293803	0.0301953	0.029380	1	0
PJA1	64219	broad.mit.edu	37	X	68381182	68381182	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:68381182C>A	ENST00000361478.1	-	2	2277	c.1900G>T	c.(1900-1902)Gtg>Ttg	p.V634L	PJA1_ENST00000374583.1_Missense_Mutation_p.V634L|PJA1_ENST00000374571.4_Missense_Mutation_p.V579L|PJA1_ENST00000374584.3_Missense_Mutation_p.V446L	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	634							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						CAGCGGCACACGGGGCAGGTG	0.552000													8	11					4.68919e-08	5.6776e-08	0.069234	1	0
NALCN	259232	broad.mit.edu	37	13	102047643	102047643	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:102047643A>T	ENST00000251127.6	-	3	263	c.182T>A	c.(181-183)tTc>tAc	p.F61Y	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Missense_Mutation_p.F61Y|NALCN_ENST00000376200.5_Missense_Mutation_p.F61Y	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	61						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATAGTGCTCGAAGGTCATTGG	0.453000													47	31					0	0	0.048971	0	0
MAGOH	4116	broad.mit.edu	37	1	53699306	53699306	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:53699306C>G	ENST00000371470.3	-	3	327	c.166G>C	c.(166-168)Gtg>Ctg	p.V56L	MAGOH_ENST00000462941.1_5'UTR|MAGOH_ENST00000371466.4_Intron	NM_002370.3	NP_002361.1	P61326	MGN_HUMAN	mago-nashi homolog, proliferation-associated (Drosophila)	56					mRNA 3'-end processing|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|exon-exon junction complex|nuclear speck	protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|urinary_tract(1)	6						TCCTCCATCACGCTTTTATGT	0.408000													15	80					0	0	0.028581	0	0
PFKFB1	5207	broad.mit.edu	37	X	54989706	54989706	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:54989706T>C	ENST00000375006.3	-	2	277	c.207A>G	c.(205-207)atA>atG	p.I69M	PFKFB1_ENST00000545676.1_Intron|PFKFB1_ENST00000374992.2_Missense_Mutation_p.I69M	NM_002625.2	NP_002616.2	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	69	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)	24						TTGGTGTTCCTATCCAGTTGA	0.453000													278	138					0	0	0.048971	0	0
STAB2	55576	broad.mit.edu	37	12	104046429	104046429	+	Silent	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:104046429A>T	ENST00000388887.2	+	12	1557	c.1353A>T	c.(1351-1353)acA>acT	p.T451T		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	451	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGAATAACACAGACATGTTCT	0.393000													22	23					0	0	0.091800	0	0
OGT	8473	broad.mit.edu	37	X	70767788	70767788	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:70767788C>G	ENST00000373719.3	+	5	780	c.563C>G	c.(562-564)cCg>cGg	p.P188R	OGT_ENST00000373701.3_Missense_Mutation_p.P178R	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	188					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GAGACGCAACCGAACTTTGCA	0.398000													28	95					0	0	0.034045	0	0
MDN1	23195	broad.mit.edu	37	6	90468013	90468013	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:90468013T>A	ENST00000369393.3	-	19	2778	c.2663A>T	c.(2662-2664)gAt>gTt	p.D888V	MDN1_ENST00000428876.1_Missense_Mutation_p.D888V			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	888					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTGCCTACATCAGTTGCTGG	0.418000													12	7					0	0	0.093190	0	0
RPL10L	140801	broad.mit.edu	37	14	47120507	47120507	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:47120507C>A	ENST00000298283.3	-	1	521	c.433G>T	c.(433-435)Gag>Tag	p.E145*		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	145					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome	p.E145K(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						ACATGCTCCTCGTTCTGAAGC	0.527000													22	88					1.96292e-10	2.49063e-10	0.055883	1	0
VCAN	1462	broad.mit.edu	37	5	82808183	82808183	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:82808183C>A	ENST00000265077.3	+	6	1575	c.1010C>A	c.(1009-1011)cCt>cAt	p.P337H	VCAN_ENST00000343200.5_Missense_Mutation_p.P337H|VCAN_ENST00000502527.2_Missense_Mutation_p.P337H|VCAN_ENST00000342785.4_Missense_Mutation_p.P337H|VCAN_ENST00000513984.1_Missense_Mutation_p.P337H|VCAN_ENST00000512590.2_Missense_Mutation_p.P289H	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	337	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTCCCTCCCCCTGATAGCAGA	0.458000													26	13					3.73148e-12	4.868e-12	0.034045	1	0
PSD3	23362	broad.mit.edu	37	8	18662320	18662320	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:18662320T>A	ENST00000440756.2	-	5	1825	c.1723A>T	c.(1723-1725)Agt>Tgt	p.S575C	PSD3_ENST00000286485.8_Missense_Mutation_p.S41C|PSD3_ENST00000327040.8_Missense_Mutation_p.S575C|PSD3_ENST00000523619.1_Missense_Mutation_p.S510C			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	575	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GTACCATTACTGAGATTTTCT	0.443000													59	90					0	0	0.048971	0	0
SLC17A2	10246	broad.mit.edu	37	6	25917015	25917015	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:25917015C>A	ENST00000377850.3	-	8	1352	c.828G>T	c.(826-828)tgG>tgT	p.W276C	SLC17A2_ENST00000265425.3_Missense_Mutation_p.W276C|SLC17A2_ENST00000360488.3_Missense_Mutation_p.W276C			O00624	NPT3_HUMAN	solute carrier family 17, member 2	276					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						GGAAAATGGCCCAAAGTGGTA	0.463000													23	65					7.4402e-23	1.10485e-22	0.091800	1	0
SERPINA9	327657	broad.mit.edu	37	14	94929496	94929496	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:94929496C>A	ENST00000337425.5	-	5	1316	c.1242G>T	c.(1240-1242)atG>atT	p.M414I	RP11-349I1.2_ENST00000536735.1_RNA|SERPINA9_ENST00000298845.7_Missense_Mutation_p.M314I|SERPINA9_ENST00000380365.3_Missense_Mutation_p.M396I|SERPINA9_ENST00000424550.2_Missense_Mutation_p.M265I|SERPINA9_ENST00000448305.2_Missense_Mutation_p.M316I	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	396					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity	p.M414I(1)		NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TATTTGTAATCATCATCAGGA	0.473000													8	247					1.06961e-07	1.28875e-07	0.038147	1	0
SLC35B3	51000	broad.mit.edu	37	6	8417116	8417116	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:8417116C>A	ENST00000379660.4	-	9	1435		c.e9+1			NM_001142540.1|NM_001142541.1|NM_015948.3	NP_001136012.1|NP_001136013.1|NP_057032.2	Q9H1N7	S35B3_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3						transmembrane transport	Golgi membrane|integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(1)|prostate(1)	15	Ovarian(93;0.0569)					ATCCCTCCTACCTGTTACAGC	0.333000													29	55					1.06647e-15	1.47436e-15	0.064281	1	0
SLIT3	6586	broad.mit.edu	37	5	168176542	168176542	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:168176542T>A	ENST00000519560.1	-	19	2491	c.2072A>T	c.(2071-2073)cAg>cTg	p.Q691L	SLIT3_ENST00000404867.3_Missense_Mutation_p.Q691L|SLIT3_ENST00000332966.8_Missense_Mutation_p.Q691L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	691	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATGGCTTCTGGCACCTAGG	0.567000													39	39					0	0	0.098360	0	0
EPHA5	2044	broad.mit.edu	37	4	66217200	66217200	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:66217200G>T	ENST00000273854.3	-	14	3015	c.2415C>A	c.(2413-2415)aaC>aaA	p.N805K	EPHA5_ENST00000511294.1_Missense_Mutation_p.N806K|EPHA5_ENST00000432638.2_Missense_Mutation_p.N642K|EPHA5_ENST00000354839.4_Missense_Mutation_p.N783K	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	805	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGATTAAGATGTTTCTGGCAG	0.468000										TSP Lung(17;0.13)			52	121					9.52127e-25	1.43692e-24	0.048971	1	0
TUBA3C	7278	broad.mit.edu	37	13	19753625	19753625	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:19753625G>A	ENST00000400113.3	-	2	186	c.82C>T	c.(82-84)Cat>Tat	p.H28Y		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	28					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGAATTCCATGTTCCAGGCAG	0.522000													27	19					0	0	0.041601	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432502	104432502	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:104432502G>T	ENST00000361820.3	-	3	2792	c.2192C>A	c.(2191-2193)aCa>aAa	p.T731K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	731					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GATGGCCACTGTTCTGCCAAA	0.433000													35	106					8.73648e-17	1.22609e-16	0.069456	1	0
OR5P2	120065	broad.mit.edu	37	11	7817741	7817741	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:7817741G>T	ENST00000329434.2	-	1	779	c.749C>A	c.(748-750)aCc>aAc	p.T250N	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GAAGGTAATGGTCCCATAGAA	0.502000													36	71					3.28013e-08	3.99766e-08	0.074837	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102294715	102294715	+	RNA	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:102294715C>T	ENST00000561463.1	+	0	2761																											AGCAGGCAGACCAAGGAGTTC	0.587000													5	1					0	0	0.014758	0	0
OR2W3	343171	broad.mit.edu	37	1	248059191	248059191	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:248059191C>T	ENST00000537741.1	+	3	560	c.303C>T	c.(301-303)ctC>ctT	p.L101L	OR2W3_ENST00000360358.3_Silent_p.L101L			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCATCCAGCTCTTCCTGTTCC	0.562000													32	113					0	0	0.050027	0	0
PDZD2	23037	broad.mit.edu	37	5	32061173	32061173	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:32061173A>G	ENST00000438447.1	+	14	2772	c.2384A>G	c.(2383-2385)cAc>cGc	p.H795R	PDZD2_ENST00000282493.3_Missense_Mutation_p.H795R			O15018	PDZD2_HUMAN	PDZ domain containing 2	795	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AGCAAAGTCCACGCCATCTTG	0.557000													31	14					0	0	0.050027	0	0
NEFL	4747	broad.mit.edu	37	8	24812994	24812994	+	RNA	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:24812994C>T	ENST00000221169.5	-	0	1630							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ACCTGCATAGCGCTGATGTCG	0.642000													9	6					0	0	0.069234	0	0
KIT	3815	broad.mit.edu	37	4	55561740	55561740	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:55561740T>C	ENST00000288135.5	+	2	227	c.130T>C	c.(130-132)Tca>Cca	p.S44P		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	44	Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TCCAGGAAAATCAGACTTAAT	0.473000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				7	35					0	0	0.029380	0	0
CLTCL1	8218	broad.mit.edu	37	22	19210312	19210312	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:19210312C>A	ENST00000263200.10	-	15	2385	c.2313G>T	c.(2311-2313)caG>caT	p.Q771H	CLTCL1_ENST00000353891.5_Missense_Mutation_p.Q771H|CLTCL1_ENST00000427926.1_Missense_Mutation_p.Q771H	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	771	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TGAGGGGAAGCTGGTCTGTGA	0.498000			T	?	ALCL								10	6					2.80697e-09	3.47821e-09	0.080935	1	0
OR2M7	391196	broad.mit.edu	37	1	248487861	248487861	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:248487861C>A	ENST00000317965.2	-	1	38	c.10G>T	c.(10-12)Gag>Tag	p.E4*		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCTGATTCTCCCATGCCATG	0.433000													87	207					3.26951e-42	5.33636e-42	0.048971	1	0
FAM13A	10144	broad.mit.edu	37	4	89950666	89950666	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:89950666G>T	ENST00000264344.5	-	2	369	c.162C>A	c.(160-162)acC>acA	p.T54T	FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000509094.1_Silent_p.T54T|FAM13A_ENST00000511976.1_5'UTR|FAM13A_ENST00000515600.1_Silent_p.T54T	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	54	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.T54T(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TGCCATTCTCGGTGAGCCCCT	0.423000													26	61					6.32553e-13	8.34025e-13	0.099896	1	0
TTC18	118491	broad.mit.edu	37	10	75072377	75072377	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:75072377G>A	ENST00000310715.3	-	11	1267	c.1147C>T	c.(1147-1149)Cgg>Tgg	p.R383W	TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000401621.2_Missense_Mutation_p.R383W|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000394865.1_Missense_Mutation_p.R383W	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	383							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CCAATATCCCGGAACAAGCTC	0.294000													39	164					0	0	0.111260	0	0
MMP27	64066	broad.mit.edu	37	11	102563669	102563669	+	Splice_Site	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:102563669C>T	ENST00000260229.4	-	9	1388	c.1297_splice	c.e9+1	p.G433_splice		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	433	Hemopexin-like 4.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		CCATGCTTACCTTTGTACTGG	0.393000													71	189					0	0	0.048971	0	0
STX2	2054	broad.mit.edu	37	12	131293210	131293210	+	Missense_Mutation	SNP	C	C	G	rs149127129	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:131293210C>G	ENST00000261653.6	-	5	486	c.320G>C	c.(319-321)cGg>cCg	p.R107P	STX2_ENST00000392373.2_Missense_Mutation_p.R107P	NM_001980.3	NP_001971.2	P32856	STX2_HUMAN	syntaxin 2	107					acrosome reaction|ectoderm development|intracellular protein transport|organ morphogenesis|signal transduction	basolateral plasma membrane|integral to membrane|microsome|soluble fraction	calcium-dependent protein binding|SNAP receptor activity	p.R107L(2)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)	16	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.79e-06)|all cancers(50;5.27e-05)|Epithelial(86;5.29e-05)		CACTGAAGTCCGGTTCCCACT	0.373000													17	117					0	0	0.028581	0	0
KCNN3	3782	broad.mit.edu	37	1	154744596	154744596	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:154744596G>A	ENST00000271915.3	-	3	1618	c.1303C>T	c.(1303-1305)Cgc>Tgc	p.R435C	KCNN3_ENST00000358505.2_Missense_Mutation_p.R122C|KCNN3_ENST00000361147.4_Missense_Mutation_p.R130C	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	440						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			CCGATGCTGCGGGACGAGGCA	0.567000													4	41					0	0	0.009096	0	0
COLEC11	78989	broad.mit.edu	37	2	3691618	3691618	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:3691618C>T	ENST00000403096.3	+	6	1139	c.648C>T	c.(646-648)tgC>tgT	p.C216C	COLEC11_ENST00000404205.1_Silent_p.C168C|COLEC11_ENST00000402794.1_Silent_p.C192C|COLEC11_ENST00000402922.1_Silent_p.C192C|COLEC11_ENST00000382062.2_Silent_p.C218C|COLEC11_ENST00000349077.4_Silent_p.C242C|COLEC11_ENST00000236693.7_Silent_p.C239C|COLEC11_ENST00000487365.1_3'UTR|COLEC11_ENST00000418971.2_Silent_p.C256C	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	242	C-type lectin.					collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		AGGAGGACTGCGTGGAGATGG	0.597000													4	13					0	0	0.009096	0	0
MYO16	23026	broad.mit.edu	37	13	109779932	109779932	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:109779932C>T	ENST00000457511.2	+	19	2826	c.2555C>T	c.(2554-2556)cCg>cTg	p.P852L	MYO16_ENST00000356711.2_Intron|MYO16_ENST00000357550.2_Intron			Q9Y6X6	MYO16_HUMAN	myosin XVI	1827	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTCGTGTTCCGGGCTCGCGC	0.602000													3	2					0	0	0.009096	0	0
TRIM43	129868	broad.mit.edu	37	2	96262129	96262129	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:96262129G>T	ENST00000272395.2	+	4	823	c.687G>T	c.(685-687)atG>atT	p.M229I		NM_001164464.1|NM_138800.1	NP_001157936.1|NP_620155.1	Q96BQ3	TRI43_HUMAN	tripartite motif containing 43	229						intracellular	zinc ion binding			breast(1)|large_intestine(3)|lung(7)|ovary(1)	12						TGAAAGAAATGTATCAGGAAC	0.398000													7	37					4.68919e-08	5.6776e-08	0.069234	1	0
CSMD1	64478	broad.mit.edu	37	8	3046498	3046498	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:3046498T>A	ENST00000602557.1	-	36	5992	c.5437A>T	c.(5437-5439)Aca>Tca	p.T1813S	CSMD1_ENST00000542608.1_Missense_Mutation_p.T1812S|CSMD1_ENST00000602723.1_Missense_Mutation_p.T1813S|CSMD1_ENST00000400186.3_Missense_Mutation_p.T1813S|CSMD1_ENST00000537824.1_Missense_Mutation_p.T1812S|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000520002.1_Missense_Mutation_p.T1813S|CSMD1_ENST00000539096.1_Missense_Mutation_p.T1812S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1813	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACAGGATTGTACCTCTTCGT	0.468000													12	15					0	0	0.093190	0	0
AGAP4	119016	broad.mit.edu	37	10	46322003	46322003	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:46322003C>A	ENST00000448048.2	-	7	1477	c.1352G>T	c.(1351-1353)cGt>cTt	p.R451L		NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	451	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)|lung(1)|ovary(1)	3						GGCGTTCCCACGCATGTTTTG	0.557000													19	72					1.85244e-09	2.31087e-09	0.083992	1	0
CMA1	1215	broad.mit.edu	37	14	24976710	24976710	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:24976710C>T	ENST00000250378.3	-	2	90	c.61G>A	c.(61-63)Gag>Aag	p.E21K	RP11-80A15.1_ENST00000555109.1_Intron|CMA1_ENST00000206446.4_Intron	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell	21					interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		CCGATGATCTCCCCTGGAACA	0.502000													50	150					0	0	0.048971	0	0
PKHD1	5314	broad.mit.edu	37	6	51923295	51923295	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:51923295C>A	ENST00000371117.3	-	16	1613	c.1338G>T	c.(1336-1338)ctG>ctT	p.L446L	PKHD1_ENST00000340994.4_Silent_p.L446L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	446					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTCCACCCAACAGCTCCAACT	0.557000													72	157					3.07281e-33	4.86529e-33	0.048971	1	0
NOXRED1	122945	broad.mit.edu	37	14	77873817	77873817	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:77873817G>T	ENST00000380835.2	-	3	687	c.521C>A	c.(520-522)cCa>cAa	p.P174Q	NOXRED1_ENST00000298358.3_Missense_Mutation_p.P174Q	NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	174					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						CCTGGGTAGTGGGATGGCAGC	0.507000													67	182					5.94106e-25	9.02116e-25	0.048971	1	0
VWCE	220001	broad.mit.edu	37	11	61048167	61048167	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:61048167T>A	ENST00000335613.5	-	9	1639	c.1253A>T	c.(1252-1254)aAg>aTg	p.K418M		NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	418	VWFC 1.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						ACACCTCACCTTTTCACAGGT	0.587000													21	33					0	0	0.083992	0	0
VCAN	1462	broad.mit.edu	37	5	82808182	82808182	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:82808182C>A	ENST00000265077.3	+	6	1574	c.1009C>A	c.(1009-1011)Cct>Act	p.P337T	VCAN_ENST00000343200.5_Missense_Mutation_p.P337T|VCAN_ENST00000502527.2_Missense_Mutation_p.P337T|VCAN_ENST00000342785.4_Missense_Mutation_p.P337T|VCAN_ENST00000513984.1_Missense_Mutation_p.P337T|VCAN_ENST00000512590.2_Missense_Mutation_p.P289T	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	337	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTTCCCTCCCCCTGATAGCAG	0.463000													26	13					3.73148e-12	4.868e-12	0.034045	1	0
MAGEA3	4102	broad.mit.edu	37	X	151935268	151935268	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:151935268G>A	ENST00000393902.3	-	3	1466	c.899C>T	c.(898-900)tCc>tTc	p.S300F	MAGEA3_ENST00000370278.3_Missense_Mutation_p.S300F			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	300	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					GGGTGGGTAGGAAATGTGAGG	0.557000													25	355					0	0	0.083992	0	0
OR4A16	81327	broad.mit.edu	37	11	55111427	55111427	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:55111427C>A	ENST00000314721.2	+	1	801	c.751C>A	c.(751-753)Ccc>Acc	p.P251T		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						CGTTTTTGTTCCCTGTATTTT	0.378000													35	73					3.76114e-14	5.07651e-14	0.069456	1	0
CACNA1C	775	broad.mit.edu	37	12	2794920	2794920	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:2794920C>T	ENST00000399655.1	+	44	5857	c.5592C>T	c.(5590-5592)gaC>gaT	p.D1864D	CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399644.1_Silent_p.D1864D|CACNA1C_ENST00000399603.1_Silent_p.D1864D|CACNA1C_ENST00000399621.1_Silent_p.D1883D|CACNA1C_ENST00000399601.1_Silent_p.D1864D|CACNA1C_ENST00000344100.3_Silent_p.D1905D|CACNA1C_ENST00000399597.1_Silent_p.D1864D|CACNA1C_ENST00000399649.1_Silent_p.D1870D|CACNA1C_ENST00000399595.1_Silent_p.D1872D|CACNA1C_ENST00000347598.4_Silent_p.D1912D|CACNA1C_ENST00000399637.1_Silent_p.D1883D|CACNA1C_ENST00000399641.1_Silent_p.D1864D|CACNA1C_ENST00000402845.3_Silent_p.D1883D|CACNA1C_ENST00000399629.1_Silent_p.D1881D|CACNA1C_ENST00000399638.1_Silent_p.D1892D|CACNA1C_ENST00000335762.5_Silent_p.D1889D|CACNA1C_ENST00000399634.1_Silent_p.D1935D|CACNA1C_ENST00000399617.1_Silent_p.D1899D|CACNA1C_ENST00000406454.3_Silent_p.D1935D|CACNA1C_ENST00000327702.7_Silent_p.D1899D|CACNA1C_ENST00000399591.1_Silent_p.D1872D|CACNA1C_ENST00000399606.1_Silent_p.D1884D	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1947					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACCAGGATGACGAAAATCGGC	0.592000													13	26					0	0	0.020292	0	0
CCIN	881	broad.mit.edu	37	9	36171016	36171016	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:36171016T>C	ENST00000335119.2	+	1	1628	c.1517T>C	c.(1516-1518)gTc>gCc	p.V506A		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	506					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TCAGTGCCTGTCTTGCCCAAC	0.547000													18	85					0	0	0.062417	0	0
OR6N1	128372	broad.mit.edu	37	1	158735630	158735630	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:158735630G>T	ENST00000335094.2	-	1	862	c.843C>A	c.(841-843)ctC>ctA	p.L281L		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					GGAAGGGTGTGAGCACTGAGT	0.502000													242	404					5.63906e-116	9.58381e-116	0.048971	1	0
RMI2	116028	broad.mit.edu	37	16	11444629	11444629	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:11444629A>G	ENST00000572173.1	+	5	882	c.237A>G	c.(235-237)ttA>ttG	p.L79L	RMI2_ENST00000381820.2_Silent_p.L79L|RMI2_ENST00000576027.1_3'UTR|RMI2_ENST00000312499.5_Silent_p.L142L			Q96E14	RMI2_HUMAN	RecQ mediated genome instability 2	142					DNA replication	nucleus	DNA binding			endometrium(1)|kidney(1)|ovary(1)	3						TAGAAGATTTACACAGGAATA	0.428000													3	39					0	0	0.009096	0	0
KLHL24	54800	broad.mit.edu	37	3	183382794	183382794	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:183382794A>T	ENST00000454652.1	+	6	1577	c.1191A>T	c.(1189-1191)agA>agT	p.R397S	KLHL24_ENST00000476808.1_Missense_Mutation_p.R397S|KLHL24_ENST00000242810.6_Missense_Mutation_p.R397S			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	397						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			ATAAAGGCAGATGGCGTCACA	0.388000													5	72					0	0	0.021553	0	0
MPP1	4354	broad.mit.edu	37	X	154014616	154014616	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:154014616C>A	ENST00000413259.3	-	7	842	c.450G>T	c.(448-450)aaG>aaT	p.K150N	MPP1_ENST00000393531.1_Splice_Site|MPP1_ENST00000462825.1_5'UTR|MPP1_ENST00000369534.3_Missense_Mutation_p.K180N	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	180	PDZ.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTCCCGCCTCCTTGCAAGGGA	0.483000													54	1269					4.14481e-20	6.06977e-20	0.086207	1	0
CPS1	1373	broad.mit.edu	37	2	211465284	211465284	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:211465284G>C	ENST00000233072.5	+	15	1751	c.1555G>C	c.(1555-1557)Gaa>Caa	p.E519Q	CPS1_ENST00000430249.2_Missense_Mutation_p.E525Q|CPS1_ENST00000451903.2_Missense_Mutation_p.E68Q	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	519					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTTAGGAGTGGAACTATTCAA	0.353000													10	85					0	0	0.069234	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802584	24802584	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:24802584G>T	ENST00000395799.3	+	6	2750	c.2621G>T	c.(2620-2622)aGc>aTc	p.S874I	TNRC6A_ENST00000315183.7_Missense_Mutation_p.S874I	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	874	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		AAGAAATCCAGCTCAGGAGGT	0.438000													21	56					1.5548e-18	2.23276e-18	0.108266	1	0
STRA6	64220	broad.mit.edu	37	15	74477340	74477340	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:74477340G>A	ENST00000323940.5	-	13	1392	c.1147C>T	c.(1147-1149)Cgc>Tgc	p.R383C	STRA6_ENST00000423167.2_Missense_Mutation_p.R374C|STRA6_ENST00000416286.3_Missense_Mutation_p.R375C|STRA6_ENST00000574278.1_Missense_Mutation_p.R398C|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000395105.4_Missense_Mutation_p.R383C|STRA6_ENST00000563965.1_Missense_Mutation_p.R422C|STRA6_ENST00000535552.1_Missense_Mutation_p.R420C|STRA6_ENST00000449139.2_Missense_Mutation_p.R383C	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	383					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						ACCAGTGAGCGCATCAGGACC	0.612000													6	28					0	0	0.038147	0	0
STOML3	161003	broad.mit.edu	37	13	39541077	39541077	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:39541077C>A	ENST00000379631.4	-	7	1105	c.761G>T	c.(760-762)aGc>aTc	p.S254I	STOML3_ENST00000423210.1_Missense_Mutation_p.S245I	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	254						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GGCTACCGTGCTCAAGGTCTG	0.507000													16	55					5.3912e-06	6.20323e-06	0.038395	1	0
DDR2	4921	broad.mit.edu	37	1	162745598	162745598	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:162745598C>A	ENST00000367922.2	+	16	2451	c.2013C>A	c.(2011-2013)ccC>ccA	p.P671P	DDR2_ENST00000367921.3_Silent_p.P671P	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	671	Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GCCACGAGCCCCCTAATTCTT	0.473000													68	135					2.00703e-41	3.26142e-41	0.048971	1	0
HOXD3	3232	broad.mit.edu	37	2	177033966	177033966	+	Missense_Mutation	SNP	G	G	A	rs138422926	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:177033966G>A	ENST00000468418.3	+	3	2214	c.124G>A	c.(124-126)Ggc>Agc	p.G42S	HOXD3_ENST00000410016.1_Missense_Mutation_p.G42S|HOXD3_ENST00000249440.3_Missense_Mutation_p.G42S			P31249	HXD3_HUMAN	homeobox D3	42					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GGACACTTACGGCTACAGCAC	0.587000													19	29					0	0	0.062417	0	0
BAI3	577	broad.mit.edu	37	6	70071172	70071172	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:70071172C>T	ENST00000370598.1	+	29	4828	c.4007C>T	c.(4006-4008)cCg>cTg	p.P1336L	BAI3_ENST00000238918.8_Missense_Mutation_p.P542L|BAI3_ENST00000546190.1_Missense_Mutation_p.P300L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1336					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GAAACCTTGCCGCATGAAAGG	0.398000													20	54					0	0	0.049695	0	0
ABCA12	26154	broad.mit.edu	37	2	215843639	215843639	+	Silent	SNP	T	T	C	rs35809021		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:215843639T>C	ENST00000272895.7	-	32	5085	c.4866A>G	c.(4864-4866)ccA>ccG	p.P1622P	ABCA12_ENST00000389661.4_Silent_p.P1304P	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1622					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGGTGCTGAATGGAGGAAGTA	0.522000													6	114					0	0	0.021553	0	0
RHBDF1	64285	broad.mit.edu	37	16	112636	112636	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:112636A>T	ENST00000262316.6	-	7	995	c.853T>A	c.(853-855)Tcg>Acg	p.S285T	RHBDF1_ENST00000454039.2_Missense_Mutation_p.S285T	NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	285					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GCTGCCTCCGATGGGGACTCG	0.617000													15	52					0	0	0.033300	0	0
FREM2	341640	broad.mit.edu	37	13	39454433	39454433	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:39454433C>A	ENST00000280481.7	+	24	9235	c.9019C>A	c.(9019-9021)Cga>Aga	p.R3007R		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	3007					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CGCTCTAGGCCGAGAATGGTA	0.403000													5	37					0.014758	0.0153375	0.014758	1	0
LOC643201	643201	broad.mit.edu	37	5	175574017	175574017	+	RNA	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:175574017G>C	ENST00000515403.1	-	0	2751				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						CTCTTTCTTGGAGATCAATAC	0.478000													6	7					0	0	0.021553	0	0
TNR	7143	broad.mit.edu	37	1	175293635	175293635	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:175293635G>T	ENST00000367674.1	-	22	4522	c.3814C>A	c.(3814-3816)Caa>Aaa	p.Q1272K	TNR_ENST00000263525.2_Missense_Mutation_p.Q1272K|RP3-518E13.2_ENST00000569593.1_RNA	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1272	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GGGCGTCCTTGATGATAGCTG	0.473000													151	361					1.97865e-72	3.33223e-72	0.048971	1	0
SIN3B	23309	broad.mit.edu	37	19	16977262	16977262	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:16977262G>A	ENST00000379803.1	+	13	1811	c.1797G>A	c.(1795-1797)gcG>gcA	p.A599A	SIN3B_ENST00000248054.5_Silent_p.A567A|SIN3B_ENST00000595541.1_Silent_p.A157A	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	599					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						ATGAGAAGGCGTACCTCAAGT	0.592000													8	24					0	0	0.038147	0	0
TDRD6	221400	broad.mit.edu	37	6	46657163	46657163	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:46657163G>A	ENST00000544460.1	+	1	1552	c.1298G>A	c.(1297-1299)cGt>cAt	p.R433H	TDRD6_ENST00000316081.6_Missense_Mutation_p.R433H	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	433					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AATCTGAACCGTGTGTTTGGA	0.463000													7	49					0	0	0.029380	0	0
NUP160	23279	broad.mit.edu	37	11	47829998	47829998	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:47829998G>A	ENST00000378460.2	-	18	2371	c.2325C>T	c.(2323-2325)ctC>ctT	p.L775L	NUP160_ENST00000530326.1_Silent_p.L661L|NUP160_ENST00000528071.1_Silent_p.L661L	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	775					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						CCCATTTAATGAGGTAATAAG	0.388000													6	32					0	0	0.029380	0	0
TRBV19	28568	broad.mit.edu	37	7	142326476	142326476	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:142326476C>A	ENST00000390393.3	+	0	114																											CTGACAAACTCTGCACATTAG	0.507000													33	30					9.65021e-13	1.26563e-12	0.045705	1	0
NXF4	55999	broad.mit.edu	37	X	101818963	101818963	+	RNA	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:101818963C>T	ENST00000360035.2	+	0	1247					NR_002216.1													p.S168S(1)		endometrium(2)|lung(8)	10						CTGACCAGTCCGCCTATGTAA	0.557000													7	107					0	0	0.029380	0	0
OR4A15	81328	broad.mit.edu	37	11	55135487	55135487	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:55135487T>C	ENST00000314706.3	+	1	128	c.128T>C	c.(127-129)tTa>tCa	p.L43S		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						TTTATCCTCTTAGGGCTCACA	0.413000													40	65					0	0	0.080422	0	0
P2RY2	5029	broad.mit.edu	37	11	72945675	72945675	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:72945675G>T	ENST00000311131.2	+	3	938	c.471G>T	c.(469-471)gtG>gtT	p.V157V	P2RY2_ENST00000393597.2_Silent_p.V157V|P2RY2_ENST00000393596.2_Silent_p.V157V	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	157					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	CCGGGGCCGTGTGGGTGTTGG	0.726000													4	19					0.00116845	0.00126213	0.021553	1	0
FTH1P3	2498	broad.mit.edu	37	5	17354546	17354546	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:17354546G>T	ENST00000511821.1	+	0	405				FTH1P10_ENST00000401830.3_RNA																							GGCGACTAAGGAGAGGCGGCT	0.687000													14	5					2.31682e-05	2.62904e-05	0.024245	1	0
TBX22	50945	broad.mit.edu	37	X	79286261	79286261	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:79286261C>A	ENST00000442340.1	+	9	1344	c.854C>A	c.(853-855)cCa>cAa	p.P285Q	TBX22_ENST00000373294.5_Missense_Mutation_p.P405Q|TBX22_ENST00000373291.1_Missense_Mutation_p.P285Q|TBX22_ENST00000373296.3_Missense_Mutation_p.P405Q	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	405					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TCTTTAGCCCCACTCATGATG	0.443000													133	145					6.63191e-72	1.11434e-71	0.048971	1	0
TIMMDC1	51300	broad.mit.edu	37	3	119232532	119232532	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:119232532C>G	ENST00000494664.1	+	5	764	c.562C>G	c.(562-564)Ctg>Gtg	p.L188V	TIMMDC1_ENST00000493694.1_Intron	NM_016589.3	NP_057673.2	Q9NPL8	TIDC1_HUMAN	translocase of inner mitochondrial membrane domain containing 1	188						integral to membrane|mitochondrial inner membrane	protein transporter activity			autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	15						CCTGCGTGGCCTGGTGGCTGG	0.378000													12	34					0	0	0.020292	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797451	148797451	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:148797451G>T	ENST00000355220.5	+	5	407	c.305G>T	c.(304-306)cGg>cTg	p.R102L	MAGEA11_ENST00000333104.4_Missense_Mutation_p.R73L	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	102						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCCACAGTTCGGCCTGCTGAC	0.542000													47	196					5.73435e-26	8.72516e-26	0.048971	1	0
TNN	63923	broad.mit.edu	37	1	175049310	175049310	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:175049310C>T	ENST00000239462.4	+	4	909	c.796C>T	c.(796-798)Cag>Tag	p.Q266*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	266	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGTCACCCCACAGGGCCTGCA	0.607000													5	58					0	0	0.014758	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444203	15444203	+	Missense_Mutation	SNP	G	G	A	rs150953206	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:15444203G>A	ENST00000295297.4	+	3	930	c.671G>A	c.(670-672)cGg>cAg	p.R224Q	C1QTNF7_ENST00000429690.1_Missense_Mutation_p.R217Q|C1QTNF7_ENST00000444304.2_Missense_Mutation_p.R217Q	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	217	C1q.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						GGGCAATACCGGATAAAGACC	0.458000													5	206					0	0	0.014758	0	0
KCNK9	51305	broad.mit.edu	37	8	140630830	140630830	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:140630830C>G	ENST00000520439.1	-	2	859	c.796G>C	c.(796-798)Gga>Cga	p.G266R	KCNK9_ENST00000303015.1_Missense_Mutation_p.G266R			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	266						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TTGCGGTTTCCGGCGAGGGAT	0.632000													21	64					0	0	0.055883	0	0
MEGF10	84466	broad.mit.edu	37	5	126732432	126732432	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:126732432G>A	ENST00000274473.6	+	7	888	c.621G>A	c.(619-621)acG>acA	p.T207T	MEGF10_ENST00000503335.2_Silent_p.T207T|MEGF10_ENST00000508365.1_Silent_p.T207T|MEGF10_ENST00000418761.2_Silent_p.T207T	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	207	EGF-like 3.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACCACGTCACGGGGGAATGCC	0.627000													4	54					0	0	0.014758	0	0
OR2B6	26212	broad.mit.edu	37	6	27925457	27925457	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:27925457G>C	ENST00000244623.1	+	1	439	c.439G>C	c.(439-441)Gca>Cca	p.A147P		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTTGGCAGCTGCATCCTGGGT	0.493000													40	80					0	0	0.098360	0	0
ZNF90	7643	broad.mit.edu	37	19	20228727	20228727	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:20228727G>A	ENST00000418063.2	+	4	476	c.364G>A	c.(364-366)Gag>Aag	p.E122K	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	122						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						AAGTGTGGATGAGGGTAAAGT	0.353000													11	26					0	0	0.093190	0	0
NONO	4841	broad.mit.edu	37	X	70510515	70510515	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:70510515G>T	ENST00000276079.8	+	3	233	c.28G>T	c.(28-30)Gag>Tag	p.E10*	NONO_ENST00000535149.1_Intron|NONO_ENST00000373841.1_Nonsense_Mutation_p.E10*|NONO_ENST00000373856.3_Nonsense_Mutation_p.E10*	NM_007363.4	NP_031389.3	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	10					DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	19	Renal(35;0.156)					TTTTAACTTGGAGAAGCAAAA	0.433000			T	TFE3	papillary renal cancer								12	16					0.000151284	0.000168321	0.105934	1	0
HTR2A	3356	broad.mit.edu	37	13	47469742	47469742	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:47469742G>A	ENST00000378688.4	-	1	431	c.300C>T	c.(298-300)tcC>tcT	p.S100S	HTR2A_ENST00000542664.1_Silent_p.S100S|HTR2A_ENST00000543956.1_Intron			P28223	5HT2A_HUMAN	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	100					ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TTTTCTCTAGGGACACTGCCA	0.443000													60	42					0	0	0.048971	0	0
ETV5	2119	broad.mit.edu	37	3	185798928	185798928	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:185798928C>T	ENST00000306376.5	-	6	515	c.269G>A	c.(268-270)cGg>cAg	p.R90Q	ETV5_ENST00000434744.1_Missense_Mutation_p.R90Q|ETV5_ENST00000537818.1_Missense_Mutation_p.R132Q	NM_004454.2	NP_004445.1	P41161	ETV5_HUMAN	ets variant 5	90					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			GTGCAGCTCCCGTTTGATCTT	0.507000			T	"""TMPRSS2, SCL45A3"""	Prostate								38	119					0	0	0.074837	0	0
PABPC5	140886	broad.mit.edu	37	X	90690871	90690871	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:90690871C>A	ENST00000312600.3	+	2	509	c.295C>A	c.(295-297)Cgc>Agc	p.R99S	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	99						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						GCCAGATGACCGCTTAAGAAA	0.428000													22	70					2.37509e-13	3.14838e-13	0.055883	1	0
CCDC129	223075	broad.mit.edu	37	7	31682379	31682379	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:31682379C>A	ENST00000319386.3	+	11	1944	c.951C>A	c.(949-951)tcC>tcA	p.S317S	CCDC129_ENST00000407970.3_Silent_p.S465S|CCDC129_ENST00000409210.1_Silent_p.S373S|CCDC129_ENST00000451887.2_Silent_p.S491S			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	465										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TAGTATCATCCCAGGACTGTC	0.517000													82	117					9.37156e-40	1.51955e-39	0.048971	1	0
B4GALNT2	124872	broad.mit.edu	37	17	47243517	47243517	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:47243517C>A	ENST00000300404.2	+	9	1235	c.1176C>A	c.(1174-1176)acC>acA	p.T392T	B4GALNT2_ENST00000504681.1_Silent_p.T306T|B4GALNT2_ENST00000393354.2_Silent_p.T332T	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	392					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CTCAGGTCACCACCAAATACG	0.473000													11	17					1.58986e-06	1.86112e-06	0.069234	1	0
SPEF2	79925	broad.mit.edu	37	5	35792527	35792527	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:35792527G>T	ENST00000440995.2	+	31	4518	c.4518G>T	c.(4516-4518)tgG>tgT	p.W1506C	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000303129.4_Missense_Mutation_p.W308C|SPEF2_ENST00000356031.3_Missense_Mutation_p.W1511C			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1511					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTAGTAATTGGATGCACCTTA	0.338000													85	30					6.44939e-38	1.04345e-37	0.048971	1	0
PCMTD1	115294	broad.mit.edu	37	8	52758276	52758276	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:52758276C>A	ENST00000360540.5	-	4	761	c.355G>T	c.(355-357)Gaa>Taa	p.E119*	PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000522514.1_Nonsense_Mutation_p.E119*|PCMTD1_ENST00000544451.1_Intron	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	119						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				TTGGCATATTCCACCACATCT	0.313000													11	26					0.00185496	0.00198918	0.105934	1	0
ANKIB1	54467	broad.mit.edu	37	7	92017170	92017170	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:92017170G>T	ENST00000265742.3	+	13	2187	c.1811G>T	c.(1810-1812)aGa>aTa	p.R604I		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	604							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TATTATACAAGATTTAAAAAC	0.303000													14	42					1.15088e-07	1.38217e-07	0.028581	1	0
LANCL2	55915	broad.mit.edu	37	7	55468883	55468883	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:55468883T>A	ENST00000254770.2	+	5	1273	c.695T>A	c.(694-696)aTt>aAt	p.I232N		NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	232					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			AATGCTATTATTGAATCGGGT	0.423000													24	48					0	0	0.108266	0	0
C11orf82	220042	broad.mit.edu	37	11	82644076	82644076	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:82644076G>T	ENST00000533655.1	+	6	1908	c.1696G>T	c.(1696-1698)Gag>Tag	p.E566*	C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000430323.2_Nonsense_Mutation_p.E566*|C11orf82_ENST00000329143.3_Nonsense_Mutation_p.E265*|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	566					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						ACCACACAGGGAGAGTGACCA	0.338000													20	26					0.000958276	0.00104578	0.043863	1	0
TREML4	285852	broad.mit.edu	37	6	41204319	41204319	+	Nonstop_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:41204319G>C	ENST00000341495.2	+	5	706	c.602G>C	c.(601-603)tGa>tCa	p.*201S	TREML4_ENST00000448827.2_Nonstop_Mutation_p.*201S	NM_198153.2	NP_937796.1	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid cells-like 4	0						extracellular region				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.196)					CTGATGTTGTGAGTCCTGTTA	0.582000													17	38					0	0	0.028581	0	0
C19orf44	84167	broad.mit.edu	37	19	16611814	16611814	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:16611814G>T	ENST00000221671.3	+	2	367	c.211G>T	c.(211-213)Ggg>Tgg	p.G71W	C19orf44_ENST00000594035.1_Missense_Mutation_p.G71W|CTD-3222D19.2_ENST00000409035.1_Intron	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	71										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						CCCTGTGCTCGGGAGTGGACC	0.507000													39	34					6.19805e-25	9.39214e-25	0.080422	1	0
KCNS2	3788	broad.mit.edu	37	8	99441529	99441529	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:99441529C>A	ENST00000287042.4	+	2	1672	c.1322C>A	c.(1321-1323)tCg>tAg	p.S441*	KCNS2_ENST00000521839.1_Nonsense_Mutation_p.S441*	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	441						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GAGGTCCCTTCGGTCAATTTA	0.448000													92	71					2.41567e-30	3.77639e-30	0.048971	1	0
MT-ND5	4540	broad.mit.edu	37	MT	13063	13063	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:13063G>A	ENST00000361567.2	+	1	727	c.727G>A	c.(727-729)Gtc>Atc	p.V243I				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	243					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	GCCCCACCCCAGTCTCAGCCC	0.547000													92	336					0	0	0.048971	0	0
CST9	128822	broad.mit.edu	37	20	23584161	23584161	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:23584161C>A	ENST00000376971.3	-	2	477	c.466G>T	c.(466-468)Gac>Tac	p.D156Y		NM_001008693.2	NP_001008693.2	Q5W186	CST9_HUMAN	cystatin 9 (testatin)	156						extracellular region	cysteine-type endopeptidase inhibitor activity			central_nervous_system(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Colorectal(13;0.0993)					TTCCCTTTGTCCCTCGGAATG	0.582000													20	31					2.94398e-08	3.59982e-08	0.043863	1	0
DOCK10	55619	broad.mit.edu	37	2	225658116	225658116	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:225658116C>A	ENST00000409592.3	-	46	5308		c.e46+1		DOCK10_ENST00000258390.7_Splice_Site			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10								GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GGTCATCTTACCCTTTCTTTT	0.358000													19	45					5.35356e-11	6.8633e-11	0.076483	1	0
ANK2	287	broad.mit.edu	37	4	114275193	114275193	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:114275193C>A	ENST00000357077.4	+	38	5472	c.5419C>A	c.(5419-5421)Cca>Aca	p.P1807T	ANK2_ENST00000264366.6_Missense_Mutation_p.P1774T|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1774	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGGCCACATCCAGCTGCGTC	0.517000													143	303					1.02165e-56	1.69361e-56	0.048971	1	0
OR10W1	81341	broad.mit.edu	37	11	58034795	58034795	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:58034795A>C	ENST00000395079.2	-	1	937	c.536T>G	c.(535-537)gTt>gGt	p.V179G		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				CTGAGCACAAACAACATGCAT	0.502000													21	105					0	0	0.069288	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232579424	232579424	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:232579424G>T	ENST00000366630.1	-	11	3719	c.3361C>A	c.(3361-3363)Ccc>Acc	p.P1121T	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.P1121T|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.P195T			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1121					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TGGTTGCTGGGTGAGCTTCTG	0.498000													27	50					3.1745e-13	4.19305e-13	0.037714	1	0
PCLO	27445	broad.mit.edu	37	7	82544953	82544953	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:82544953C>G	ENST00000423517.2	-	7	12686	c.12349G>C	c.(12349-12351)Gat>Cat	p.D4117H	PCLO_ENST00000333891.8_Missense_Mutation_p.D4117H|PCLO_ENST00000437081.1_Missense_Mutation_p.D837H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4048					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCGTAAGGATCCTCCATTGGG	0.438000													34	53					0	0	0.059317	0	0
CASP5	838	broad.mit.edu	37	11	104871220	104871220	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:104871220A>G	ENST00000393141.2	-	6	790	c.759T>C	c.(757-759)gaT>gaC	p.D253D	CASP5_ENST00000393139.2_3'UTR|CASP5_ENST00000260315.3_Silent_p.D240D|CASP5_ENST00000418434.1_Silent_p.D98D|CASP5_ENST00000526056.1_Silent_p.D253D|CASP5_ENST00000444749.2_Silent_p.D182D|CASP5_ENST00000531367.1_Silent_p.D98D	NM_001136112.1|NM_004347.3	NP_001129584.1|NP_004338.3	P51878	CASP5_HUMAN	caspase 5, apoptosis-related cysteine peptidase	240					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|ovary(3)|skin(1)|urinary_tract(1)	35		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		CTGACTCCATATCCTATAAAA	0.438000													46	55					0	0	0.045515	0	0
HECTD2	143279	broad.mit.edu	37	10	93260329	93260329	+	Missense_Mutation	SNP	G	G	C	rs111679609		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:93260329G>C	ENST00000446394.1	+	20	2133	c.2033G>C	c.(2032-2034)aGa>aCa	p.R678T	HECTD2_ENST00000298068.5_Missense_Mutation_p.R674T|HECTD2_ENST00000371667.1_Missense_Mutation_p.R324T|HECTD2_ENST00000536715.1_Missense_Mutation_p.R263T			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	674	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						GCTCTGCAGAGAAGTACTCAG	0.413000													17	72					0	0	0.038395	0	0
NFASC	23114	broad.mit.edu	37	1	204923420	204923420	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:204923420G>T	ENST00000367172.4	+	6	648	c.320G>T	c.(319-321)gGg>gTg	p.G107V	NFASC_ENST00000367171.4_Missense_Mutation_p.G107V|NFASC_ENST00000403080.1_Missense_Mutation_p.G107V|NFASC_ENST00000404907.1_Missense_Mutation_p.G101V|NFASC_ENST00000339876.6_Missense_Mutation_p.G107V|NFASC_ENST00000338515.6_Missense_Mutation_p.G107V|NFASC_ENST00000367170.4_Missense_Mutation_p.G107V|NFASC_ENST00000513543.1_Missense_Mutation_p.G101V|NFASC_ENST00000360049.4_Missense_Mutation_p.G101V|NFASC_ENST00000539706.1_Missense_Mutation_p.G101V|NFASC_ENST00000404076.1_Missense_Mutation_p.G101V|NFASC_ENST00000338586.6_Missense_Mutation_p.G107V|NFASC_ENST00000401399.1_Missense_Mutation_p.G107V|NFASC_ENST00000367169.4_Missense_Mutation_p.G107V			O94856	NFASC_HUMAN	neurofascin	107	Ig-like C2-type 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CGCAGTGGCGGGCGGCCGGAG	0.582000													31	26					4.74835e-14	6.39733e-14	0.045705	1	0
FLG2	388698	broad.mit.edu	37	1	152326871	152326871	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152326871G>T	ENST00000388718.5	-	3	3463	c.3391C>A	c.(3391-3393)Cat>Aat	p.H1131N	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1131	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGACCCATGTTGTCCAAAG	0.517000													104	367					8.78727e-49	1.44697e-48	0.048971	1	0
NXF3	56000	broad.mit.edu	37	X	102337996	102337996	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:102337996G>T	ENST00000395065.3	-	7	728	c.627C>A	c.(625-627)gcC>gcA	p.A209A	NXF3_ENST00000425463.2_Silent_p.A120A|NXF3_ENST00000425644.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	209						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						GTTGGTTCATGGCCAGCTGCA	0.498000													170	200					6.08379e-84	1.0269e-83	0.048971	1	0
KCNT2	343450	broad.mit.edu	37	1	196309515	196309515	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:196309515T>G	ENST00000367433.5	-	16	1840	c.1739A>C	c.(1738-1740)cAt>cCt	p.H580P	KCNT2_ENST00000367431.4_Missense_Mutation_p.H530P|KCNT2_ENST00000294725.8_Missense_Mutation_p.H580P|KCNT2_ENST00000451324.2_Missense_Mutation_p.H191P|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	580						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GGAAGGTCCATGATAAAACGA	0.299000													44	123					0	0	0.048971	0	0
UNC79	57578	broad.mit.edu	37	14	94084621	94084621	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:94084621T>A	ENST00000553484.1	+	30	4528	c.4374T>A	c.(4372-4374)caT>caA	p.H1458Q	UNC79_ENST00000393151.2_Missense_Mutation_p.H1436Q|UNC79_ENST00000555664.1_Missense_Mutation_p.H1436Q|UNC79_ENST00000256339.4_Missense_Mutation_p.H1259Q			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1436						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CGCAGTATCATAGCTGCAAGC	0.433000													43	56					0	0	0.042209	0	0
PGS1	9489	broad.mit.edu	37	17	76396790	76396790	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:76396790G>A	ENST00000262764.6	+	6	760	c.734G>A	c.(733-735)cGc>cAc	p.R245H	PGS1_ENST00000588281.1_3'UTR|PGS1_ENST00000329897.7_Missense_Mutation_p.R110H	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	245					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			TTCACCAACCGCCAGGACCGC	0.612000													37	100					0	0	0.086207	0	0
UBQLN2	29978	broad.mit.edu	37	X	56591133	56591133	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:56591133A>C	ENST00000338222.5	+	1	1108	c.827A>C	c.(826-828)cAa>cCa	p.Q276P		NM_013444.3	NP_038472.2	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	276						cytoplasm|nucleus|plasma membrane	binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)	21						ACTGACATTCAAGAGCCGATG	0.512000													42	42					0	0	0.048971	0	0
LPAR1	1902	broad.mit.edu	37	9	113704157	113704157	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:113704157T>C	ENST00000374431.3	-	4	720	c.337A>G	c.(337-339)Act>Gct	p.T113A	LPAR1_ENST00000358883.4_Missense_Mutation_p.T113A|LPAR1_ENST00000538760.1_Missense_Mutation_p.T114A|LPAR1_ENST00000374430.2_Missense_Mutation_p.T113A|LPAR1_ENST00000541779.1_Missense_Mutation_p.T114A	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	113					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AGTCTCCGAGTATTGGGTCCT	0.488000													107	175					0	0	0.048971	0	0
MLH3	27030	broad.mit.edu	37	14	75514425	75514425	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:75514425C>T	ENST00000355774.2	-	2	2149	c.1934G>A	c.(1933-1935)aGa>aAa	p.R645K	MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000238662.7_Missense_Mutation_p.R645K|MLH3_ENST00000556740.1_Missense_Mutation_p.R645K|MLH3_ENST00000556257.1_Missense_Mutation_p.R645K	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	645					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		ATGACGTGTTCTATTTCCAAA	0.343000								Mismatch excision repair (MMR)					21	28					0	0	0.091800	0	0
NRAP	4892	broad.mit.edu	37	10	115364594	115364594	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:115364594C>A	ENST00000369358.4	-	35	4269	c.4025G>T	c.(4024-4026)tGc>tTc	p.C1342F	NRAP_ENST00000369360.3_Missense_Mutation_p.C1307F|NRAP_ENST00000359988.3_Missense_Mutation_p.C1334F|NRAP_ENST00000360478.3_Missense_Mutation_p.C1299F			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1334						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CATGCGCCGGCAGTGCTGGAT	0.597000													17	41					2.94398e-08	3.59982e-08	0.043863	1	0
NKG7	4818	broad.mit.edu	37	19	51875431	51875431	+	Silent	SNP	G	G	A	rs144240268		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:51875431G>A	ENST00000221978.5	-	2	467	c.288C>T	c.(286-288)acC>acT	p.T96T	NKG7_ENST00000600427.1_Silent_p.T61T|NKG7_ENST00000595217.1_Silent_p.T61T	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	96						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CAAAGGCTGCGGTGGTTGAGA	0.622000													15	33					0	0	0.024245	0	0
DPY19L2	283417	broad.mit.edu	37	12	64061933	64061933	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:64061933G>T	ENST00000324472.4	-	1	424	c.241C>A	c.(241-243)Ccc>Acc	p.P81T	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	81					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AACTGGAAGGGGCCGAGAAGA	0.612000													24	101					1.64293e-13	2.19354e-13	0.083992	1	0
IQCJ	654502	broad.mit.edu	37	3	158983086	158983086	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:158983086G>A	ENST00000482126.1	+	4	398	c.293G>A	c.(292-294)aGg>aAg	p.R98K	IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ-SCHIP1_ENST00000485419.1_Intron|IQCJ_ENST00000451172.1_Missense_Mutation_p.R125K|IQCJ-SCHIP1_ENST00000476809.1_Intron	NM_001197100.1	NP_001184029.1			IQ motif containing J											cervix(1)|endometrium(2)|large_intestine(2)|lung(10)	15			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			CCTGGTGGAAGGAAGGTGATT	0.507000													91	163					0	0	0.048971	0	0
BAI2	576	broad.mit.edu	37	1	32222001	32222001	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:32222001C>A	ENST00000373658.3	-	4	778	c.437G>T	c.(436-438)gGc>gTc	p.G146V	BAI2_ENST00000527361.1_Missense_Mutation_p.G146V|BAI2_ENST00000398542.1_Missense_Mutation_p.G134V|BAI2_ENST00000257070.4_Missense_Mutation_p.G146V|BAI2_ENST00000398556.3_Missense_Mutation_p.G149V|BAI2_ENST00000373655.2_Missense_Mutation_p.G146V|BAI2_ENST00000398538.1_Missense_Mutation_p.G134V|BAI2_ENST00000398547.1_Missense_Mutation_p.G134V	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	146					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GGTAAAGGGGCCTGAGCCGCT	0.706000													3	5					0.004672	0.00493156	0.004672	1	0
PLEKHA6	22874	broad.mit.edu	37	1	204218035	204218035	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:204218035C>T	ENST00000272203.3	-	12	2054	c.1738G>A	c.(1738-1740)Gcc>Acc	p.A580T	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.A600T	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	580										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TCTGGGTAGGCGGGCTGGCTT	0.572000													4	21					0	0	0.029380	0	0
AGBL3	340351	broad.mit.edu	37	7	134719543	134719543	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:134719543C>A	ENST00000458078.1	+	7	1454	c.1123C>A	c.(1123-1125)Ccc>Acc	p.P375T	AGBL3_ENST00000436302.2_Missense_Mutation_p.P401T|AGBL3_ENST00000435976.2_Missense_Mutation_p.P401T			Q8NEM8	CBPC3_HUMAN	ATP/GTP binding protein-like 3	401					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|lung(2)|skin(3)	10						CAAGGTGGTACCCATGCTCAA	0.418000													5	14					0.0381472	0.039043	0.038147	1	0
HIVEP1	3096	broad.mit.edu	37	6	12124121	12124121	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:12124121C>T	ENST00000379388.2	+	4	4425	c.4093C>T	c.(4093-4095)Cgt>Tgt	p.R1365C		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1365					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GGAAATGAGGCGTACTGCATC	0.458000													8	108					0	0	0.047766	0	0
PIWIL4	143689	broad.mit.edu	37	11	94351135	94351135	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:94351135G>T	ENST00000299001.6	+	17	2241	c.2030G>T	c.(2029-2031)tGg>tTg	p.W677L	RP11-867G2.8_ENST00000537874.1_RNA|PIWIL4_ENST00000537419.1_Missense_Mutation_p.W28L|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	677	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTCAACAAATGGTACAAGTAC	0.378000													39	102					8.72198e-27	1.32983e-26	0.048971	1	0
FMR1NB	158521	broad.mit.edu	37	X	147084781	147084781	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:147084781G>C	ENST00000370467.3	+	2	412	c.338G>C	c.(337-339)gGc>gCc	p.G113A		NM_152578.2	NP_689791.1	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	113						integral to membrane				breast(2)|cervix(1)|endometrium(3)|large_intestine(7)|lung(10)|ovary(1)|skin(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					AATGCTCATGGCCAATCTCTG	0.368000													51	195					0	0	0.048971	0	0
TMEM194A	23306	broad.mit.edu	37	12	57457954	57457954	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:57457954G>A	ENST00000300128.4	-	6	677	c.654C>T	c.(652-654)taC>taT	p.Y218Y	TMEM194A_ENST00000379391.3_Silent_p.Y145Y	NM_001130963.1	NP_001124435.1	O14524	T194A_HUMAN	transmembrane protein 194A	218						integral to membrane				endometrium(3)|large_intestine(3)|lung(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CCAGGATGACGTAAATGGGAC	0.353000													40	12					0	0	0.104719	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857109	101857109	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:101857109G>A	ENST00000604957.1	+	1	2662	c.40G>A	c.(40-42)Gct>Act	p.A14T	ARMCX5_ENST00000246174.2_Missense_Mutation_p.A14T|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000537008.1_Missense_Mutation_p.A14T|RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000541409.1_Missense_Mutation_p.A14T|ARMCX5_ENST00000536530.1_Missense_Mutation_p.A14T|ARMCX5_ENST00000372742.1_Missense_Mutation_p.A14T	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	14							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						TAGAGGAAAGGCTGAGGCTGG	0.517000													96	145					0	0	0.048971	0	0
ADAM21	8747	broad.mit.edu	37	14	70925650	70925650	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:70925650T>A	ENST00000603540.1	+	2	1692	c.1434T>A	c.(1432-1434)aaT>aaA	p.N478K	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Missense_Mutation_p.N478K	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	478	Disintegrin.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AATGGTGCAATGGAACATCTC	0.468000													22	86					0	0	0.069288	0	0
CELA1	1990	broad.mit.edu	37	12	51733776	51733776	+	Silent	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:51733776C>G	ENST00000293636.1	-	6	517	c.477G>C	c.(475-477)ctG>ctC	p.L159L		NM_001971.5	NP_001962.3	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	159	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15						GGGTCTGGGCCAGCTGCCCAT	0.587000													4	11					0	0	0.014758	0	0
URI1	8725	broad.mit.edu	37	19	30499946	30499946	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:30499946A>T	ENST00000392271.1	+	8	1018	c.493A>T	c.(493-495)Acg>Tcg	p.T165S	URI1_ENST00000542441.2_Missense_Mutation_p.T241S|URI1_ENST00000312051.6_Missense_Mutation_p.T201S|URI1_ENST00000360605.4_Missense_Mutation_p.T223S	NM_003796.3	NP_003787.2	O94763	RMP_HUMAN	URI1, prefoldin-like chaperone	241					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding										TGGAGAAGATACGACATCTTC	0.348000													8	52					0	0	0.058154	0	0
SOX7	83595	broad.mit.edu	37	8	10583458	10583458	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:10583458G>A	ENST00000304501.1	-	2	1035	c.957C>T	c.(955-957)agC>agT	p.S319S	SOX7_ENST00000554914.1_Silent_p.S371S|SOX7_ENST00000553390.1_Silent_p.S371S	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	319	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		GTTCCACCTGGCTCAGTTGAT	0.627000													12	15					0	0	0.020292	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93147902	93147902	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:93147902G>A	ENST00000344636.3	+	6	536	c.352G>A	c.(352-354)Gtg>Atg	p.V118M		NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	118	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.V118L(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						ACGGCTCCACGTGCCAGAGCT	0.507000													29	41					0	0	0.034045	0	0
FLG	2312	broad.mit.edu	37	1	152275520	152275520	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152275520C>A	ENST00000368799.1	-	3	11877	c.11842G>T	c.(11842-11844)Ggc>Tgc	p.G3948C	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3948	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGGACTGCCACGTGACTGT	0.438000									Ichthyosis				31	118					3.67414e-24	5.52239e-24	0.050027	1	0
COL7A1	1294	broad.mit.edu	37	3	48609589	48609589	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:48609589G>T	ENST00000328333.8	-	90	7101	c.6994C>A	c.(6994-6996)Cga>Aga	p.R2332R	COL7A1_ENST00000454817.1_Silent_p.R2300R	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2332	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGCAGTCCTCGGTCACCTTTG	0.607000													5	6					0.014758	0.0153375	0.014758	1	0
SLC15A4	121260	broad.mit.edu	37	12	129299387	129299387	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:129299387C>A	ENST00000266771.5	-	2	814	c.775G>T	c.(775-777)Gac>Tac	p.D259Y	SLC15A4_ENST00000539703.1_5'UTR	NM_145648.3	NP_663623.1	Q8N697	S15A4_HUMAN	solute carrier family 15 (oligopeptide transporter), member 4	259					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|skin(1)	22	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		TTGAACATGTCGGTGAAGGCA	0.517000													3	52					0.004672	0.00493156	0.004672	1	0
ZNF699	374879	broad.mit.edu	37	19	9406725	9406725	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:9406725C>A	ENST00000591998.1	-	6	1583	c.1355G>T	c.(1354-1356)tGt>tTt	p.C452F	ZNF699_ENST00000308650.3_Missense_Mutation_p.C452F			Q32M78	ZN699_HUMAN	zinc finger protein 699	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGCCTTCCCACATTCCTTACA	0.423000													3	20					6.4e-05	7.19636e-05	0.004672	1	0
PLCZ1	89869	broad.mit.edu	37	12	18854510	18854510	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:18854510A>G	ENST00000538330.1	-	5	669	c.288T>C	c.(286-288)tcT>tcC	p.S96S	PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000266505.7_Intron|PLCZ1_ENST00000447925.2_Intron|PLCZ1_ENST00000541695.1_Intron|PLCZ1_ENST00000542762.1_Intron|PLCZ1_ENST00000435379.1_Intron			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	317					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CTCCTAAAACAGATTCCAATA	0.438000													5	48					0	0	0.021553	0	0
SNAP91	9892	broad.mit.edu	37	6	84333034	84333034	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:84333034G>C	ENST00000428679.2	-	9	1386	c.793C>G	c.(793-795)Cct>Gct	p.P265A	SNAP91_ENST00000439399.2_Missense_Mutation_p.P265A|SNAP91_ENST00000521485.1_Missense_Mutation_p.P265A|SNAP91_ENST00000369694.2_Missense_Mutation_p.P265A|SNAP91_ENST00000521743.1_Missense_Mutation_p.P265A|SNAP91_ENST00000520302.1_Missense_Mutation_p.P265A|SNAP91_ENST00000195649.6_Missense_Mutation_p.P265A|SNAP91_ENST00000437520.1_Intron|SNAP91_ENST00000520213.1_Intron			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	265					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GTGAGGTCAGGAATGTCACCT	0.328000													9	9					0	0	0.069234	0	0
CRP	1401	broad.mit.edu	37	1	159683718	159683718	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:159683718T>A	ENST00000255030.5	-	2	375	c.272A>T	c.(271-273)tAc>tTc	p.Y91F	CRP_ENST00000368111.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_5'UTR|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	91	Pentaxin.			Missing (in Ref. 13; AA sequence).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TGTAAAACTGTATCCTATATC	0.453000													76	87					0	0	0.048971	0	0
NUTM1	256646	broad.mit.edu	37	15	34640442	34640442	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:34640442G>T	ENST00000537011.1	+	3	755	c.373G>T	c.(373-375)Ggg>Tgg	p.G125W	NUTM1_ENST00000438749.3_Missense_Mutation_p.G115W|NUTM1_ENST00000333756.4_Missense_Mutation_p.G97W					NUT midline carcinoma, family member 1																		GACAGAAGGGGGGTCAGCTGA	0.592000													38	22					4.14481e-20	6.06977e-20	0.086207	1	0
CYLC1	1538	broad.mit.edu	37	X	83127978	83127978	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:83127978C>A	ENST00000329312.4	+	4	299	c.262C>A	c.(262-264)Cca>Aca	p.P88T		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	88					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TTTGCAATGGCCACCCATTTA	0.368000													16	54					1.15088e-07	1.38217e-07	0.028581	1	0
GRM8	2918	broad.mit.edu	37	7	126173116	126173116	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:126173116G>T	ENST00000339582.2	-	9	3128	c.2320C>A	c.(2320-2322)Cca>Aca	p.P774T	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Missense_Mutation_p.P774T|GRM8_ENST00000358373.3_Missense_Mutation_p.P774T			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	774					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AAAGTCTCTGGGACACCTCTC	0.413000										HNSCC(24;0.065)			24	48					7.87624e-14	1.0573e-13	0.076483	1	0
LRP1B	53353	broad.mit.edu	37	2	141083421	141083421	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:141083421G>A	ENST00000389484.3	-	80	13221	c.12250C>T	c.(12250-12252)Cgc>Tgc	p.R4084C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4084					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAATATATGCGTTCACTAAAA	0.378000										TSP Lung(27;0.18)			4	138					0	0	0.014758	0	0
CD8B	926	broad.mit.edu	37	2	87085255	87085255	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:87085255C>T	ENST00000390655.6	-	2	386	c.328G>A	c.(328-330)Gac>Aac	p.D110N	CD8B_ENST00000349455.3_Missense_Mutation_p.D110N|CD8B_ENST00000331469.2_Missense_Mutation_p.D110N|CD8B_ENST00000393761.2_Missense_Mutation_p.D110N|CD8B_ENST00000393759.2_Missense_Mutation_p.D110N|CD8B_ENST00000431506.2_Intron	NM_004931.4	NP_004922.1	P10966	CD8B_HUMAN	CD8b molecule	110	Ig-like V-type.				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	13						ATGCCACTGTCTTCCGGCTTC	0.527000													12	43					0	0	0.093190	0	0
NTMT1	28989	broad.mit.edu	37	9	132397704	132397704	+	Silent	SNP	C	C	T	rs151072869		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:132397704C>T	ENST00000372486.1	+	4	982	c.633C>T	c.(631-633)ccC>ccT	p.P211P	NTMT1_ENST00000372481.3_3'UTR|NTMT1_ENST00000372480.1_Silent_p.P211P|NTMT1_ENST00000482347.1_Silent_p.P123P|NTMT1_ENST00000372483.4_Silent_p.P211P					N-terminal Xaa-Pro-Lys N-methyltransferase 1																		AGAACCTCCCCGATGAGATCT	0.627000													8	22					0	0	0.047766	0	0
ME3	10873	broad.mit.edu	37	11	86157427	86157427	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:86157427C>G	ENST00000543262.1	-	13	1809	c.1483G>C	c.(1483-1485)Ggg>Cgg	p.G495R	ME3_ENST00000359636.2_Missense_Mutation_p.G495R|ME3_ENST00000393324.3_Missense_Mutation_p.G495R|RP11-317J19.1_ENST00000524610.1_RNA	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	495					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	AGTGCCACCCCGGGGAACACG	0.547000													12	78					0	0	0.105934	0	0
EPHA7	2045	broad.mit.edu	37	6	93967898	93967898	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:93967898T>C	ENST00000369303.4	-	11	2213	c.2029A>G	c.(2029-2031)Aga>Gga	p.R677G		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	677	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		AAAAAGTCTCTCCTTTGTTTT	0.428000													11	24					0	0	0.093190	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121684623	121684623	+	Splice_Site	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:121684623G>T	ENST00000393386.2	+	23	6495		c.e23+1		PTPRZ1_ENST00000449182.1_Splice_Site	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1						central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACAATTCCAGGTGAGTCCTCT	0.463000													18	37					1.33834e-09	1.67802e-09	0.043863	1	0
GABRQ	55879	broad.mit.edu	37	X	151820033	151820033	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:151820033C>G	ENST00000370306.2	+	8	966	c.946C>G	c.(946-948)Cgg>Ggg	p.R316G		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	316						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					CTCACATCTGCGGGATAAGCT	0.458000													34	296					0	0	0.050027	0	0
CCDC108	255101	broad.mit.edu	37	2	219892638	219892638	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:219892638G>A	ENST00000341552.5	-	13	2028	c.1945C>T	c.(1945-1947)Ccg>Tcg	p.P649S	CCDC108_ENST00000453220.1_Missense_Mutation_p.P649S|CCDC108_ENST00000410037.1_Missense_Mutation_p.P584S|CCDC108_ENST00000409865.3_Missense_Mutation_p.P638S|CCDC108_ENST00000441968.1_Missense_Mutation_p.P649S	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	649						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGATGGGCGGGGGGAAGATG	0.617000													10	23					0	0	0.069234	0	0
ASB15	142685	broad.mit.edu	37	7	123264718	123264718	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:123264718G>T	ENST00000451558.1	+	10	1068	c.547G>T	c.(547-549)Gaa>Taa	p.E183*	RP11-390E23.3_ENST00000429396.1_RNA|ASB15_ENST00000451215.1_Nonsense_Mutation_p.E183*|ASB15_ENST00000434204.1_Nonsense_Mutation_p.E183*|RP11-390E23.3_ENST00000418409.1_RNA|ASB15_ENST00000540573.1_Nonsense_Mutation_p.E183*|RP11-390E23.3_ENST00000451016.1_RNA|ASB15_ENST00000275699.3_Nonsense_Mutation_p.E183*|RP11-390E23.3_ENST00000440504.1_RNA			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	183					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						AGCAATGCATGAAGCAGCCAA	0.498000											OREG0018282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	148					1.22574e-08	1.50625e-08	0.069288	1	0
ADD2	119	broad.mit.edu	37	2	70903899	70903899	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:70903899C>T	ENST00000413157.2	-	13	2101	c.1622G>A	c.(1621-1623)gGg>gAg	p.G541E	ADD2_ENST00000264436.3_Intron|ADD2_ENST00000407644.2_Intron|ADD2_ENST00000355733.3_Intron|ADD2_ENST00000430656.1_Missense_Mutation_p.G557E	NM_017482.3	NP_059516.2	P35612	ADDB_HUMAN	adducin 2 (beta)	542					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						ACACGTTTCCCCGCCAGTCAG	0.637000													10	22					0	0	0.093190	0	0
AFF2	2334	broad.mit.edu	37	X	148038095	148038095	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:148038095T>A	ENST00000370460.2	+	11	2999	c.2520T>A	c.(2518-2520)gcT>gcA	p.A840A	AFF2_ENST00000342251.3_Silent_p.A807A|AFF2_ENST00000370457.5_Silent_p.A807A|AFF2_ENST00000286437.5_Silent_p.A481A	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	840					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GTCAGACAGCTGTCACAGCTG	0.527000													125	68					0	0	0.048971	0	0
ZNF98	148198	broad.mit.edu	37	19	22586274	22586274	+	Missense_Mutation	SNP	A	A	T	rs149305274	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:22586274A>T	ENST00000357774.5	-	2	192	c.71T>A	c.(70-72)cTg>cAg	p.L24Q	ZNF98_ENST00000601553.1_Missense_Mutation_p.L24Q	NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CCACTCCTCCAGAGAGAATTC	0.403000													4	149					0	0	0.014758	0	0
EPHB1	2047	broad.mit.edu	37	3	134670328	134670328	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:134670328G>T	ENST00000398015.3	+	3	609	c.239G>T	c.(238-240)cGg>cTg	p.R80L	EPHB1_ENST00000488154.1_3'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	80						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						ATCAACCGGCGGGGGGCCCAT	0.547000													20	44					2.37509e-13	3.14838e-13	0.055883	1	0
ZNF549	256051	broad.mit.edu	37	19	58046558	58046558	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:58046558A>T	ENST00000602149.1	+	3	267	c.119A>T	c.(118-120)gAg>gTg	p.E40V	ZNF549_ENST00000376233.3_Missense_Mutation_p.E40V|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.E27V			Q6P9A3	ZN549_HUMAN	zinc finger protein 549	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCCAGGAGGAGTGGGGCCTC	0.498000													84	43					0	0	0.048971	0	0
ZSCAN9	7746	broad.mit.edu	37	6	28195201	28195201	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:28195201G>T	ENST00000527436.1	+	2	440	c.339G>T	c.(337-339)agG>agT	p.R113S	ZSCAN9_ENST00000425468.2_Missense_Mutation_p.R113S|ZSCAN9_ENST00000252207.5_Missense_Mutation_p.R113S|ZSCAN9_ENST00000531981.1_Missense_Mutation_p.R113S|ZSCAN9_ENST00000531979.1_Missense_Mutation_p.R113S					zinc finger and SCAN domain containing 9																		GCTGGGTGAGGGAACACTGTC	0.527000													38	54					7.05121e-23	1.04919e-22	0.039052	1	0
ABCB1	5243	broad.mit.edu	37	7	87174155	87174155	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:87174155C>G	ENST00000265724.3	-	17	2465	c.2048G>C	c.(2047-2049)aGt>aCt	p.S683T	ABCB1_ENST00000543898.1_Missense_Mutation_p.S619T	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	683					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTCTTTGGTACTAAGCTTTCT	0.453000													26	147					0	0	0.030593	0	0
SERPINA4	5267	broad.mit.edu	37	14	95035874	95035874	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:95035874C>A	ENST00000557004.1	+	5	1647	c.1226C>A	c.(1225-1227)tCc>tAc	p.S409Y	SERPINA4_ENST00000298841.5_Missense_Mutation_p.S409Y|SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Missense_Mutation_p.S409Y			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	409					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		GTGATCTTTTCCACCAGCACC	0.577000													47	48					2.23044e-30	3.49419e-30	0.048971	1	0
POU3F4	5456	broad.mit.edu	37	X	82764010	82764010	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:82764010G>T	ENST00000373200.2	+	1	742	c.678G>T	c.(676-678)gtG>gtT	p.V226V	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	226	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						ATGGTAACGTGTTCTCGCAGA	0.532000													48	166					6.64032e-35	1.06045e-34	0.048971	1	0
KCND3	3752	broad.mit.edu	37	1	112524390	112524390	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:112524390T>A	ENST00000369697.1	-	1	1028	c.959A>T	c.(958-960)gAa>gTa	p.E320V	KCND3_ENST00000315987.2_Missense_Mutation_p.E320V|KCND3_ENST00000302127.4_Missense_Mutation_p.E320V			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	320						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		AAAGCCCAGTTCGGAGGCACA	0.567000													18	63					0	0	0.043863	0	0
SLC22A23	63027	broad.mit.edu	37	6	3287280	3287280	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:3287280C>A	ENST00000436008.2	-	7	1821	c.1359G>T	c.(1357-1359)atG>atT	p.M453I	PSMG4_ENST00000451246.2_Intron|SLC22A23_ENST00000406686.3_Missense_Mutation_p.M453I|SLC22A23_ENST00000380302.4_Missense_Mutation_p.M172I|SLC22A23_ENST00000490273.1_Missense_Mutation_p.M172I			A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23	453					ion transport	integral to membrane	transmembrane transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				CCTCGTGGCCCATCATGCTCC	0.642000													14	25					1.99824e-07	2.39207e-07	0.033300	1	0
SPICE1	152185	broad.mit.edu	37	3	113212901	113212901	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:113212901C>T	ENST00000295872.4	-	5	639	c.380G>A	c.(379-381)cGc>cAc	p.R127H		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	127					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						AATACCTGTGCGCCTACGAGG	0.368000													10	41					0	0	0.069234	0	0
ARSF	416	broad.mit.edu	37	X	3030288	3030288	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:3030288C>T	ENST00000381127.1	+	11	1685	c.1464C>T	c.(1462-1464)acC>acT	p.T488T	ARSF_ENST00000537104.1_Silent_p.T488T|ARSF_ENST00000359361.2_Silent_p.T488T	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	488						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTATGTCACCTCATTATGCA	0.547000													19	22					0	0	0.055883	0	0
CDH22	64405	broad.mit.edu	37	20	44879714	44879714	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:44879714C>G	ENST00000372262.3	-	1	620	c.220G>C	c.(220-222)Gag>Cag	p.E74Q	CDH22_ENST00000537909.1_Missense_Mutation_p.E74Q	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	74	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CCCGTGTACTCCTCTACCACG	0.667000													3	33					0	0	0.009096	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11559	11559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:11559G>A	ENST00000361381.2	+	1	800	c.800G>A	c.(799-801)tGa>tAa	p.267_267ins*						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						ACTATCCCTATGAGGCATAAT	0.443000													78	473					0	0	0.048971	0	0
UBR2	23304	broad.mit.edu	37	6	42611955	42611955	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:42611955G>C	ENST00000372901.1	+	19	2359	c.2101G>C	c.(2101-2103)Ggt>Cgt	p.G701R	UBR2_ENST00000372883.3_Missense_Mutation_p.G205R|UBR2_ENST00000372899.1_Missense_Mutation_p.G701R			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	701					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AAAAAAGACAGGTGTCTCCAT	0.373000													26	54					0	0	0.037714	0	0
HS3ST5	222537	broad.mit.edu	37	6	114383950	114383950	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:114383950G>A	ENST00000312719.5	-	4	1248	c.60C>T	c.(58-60)gcC>gcT	p.A20A	HS3ST5_ENST00000411826.1_Silent_p.A20A|RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	20					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GACTCCCAACGGCAAGGCTTC	0.522000													35	134					0	0	0.074837	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208622	140208622	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140208622T>C	ENST00000529310.1	+	1	1060	c.946T>C	c.(946-948)Tac>Cac	p.Y316H	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.Y316H|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAAACTTATACAAAATCCT	0.418000													14	7					0	0	0.091800	0	0
BACE2	25825	broad.mit.edu	37	21	42647496	42647496	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:42647496G>T	ENST00000330333.6	+	9	1965	c.1502G>T	c.(1501-1503)cGt>cTt	p.R501L	BACE2_ENST00000466122.1_3'UTR|BACE2_ENST00000328735.6_3'UTR|BACE2_ENST00000347667.4_Missense_Mutation_p.R451L	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	501					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				CGTCGCCCCCGTGACCCTGAG	0.542000													21	34					8.58068e-18	1.22275e-17	0.034045	1	0
RAB6A	5870	broad.mit.edu	37	11	73429723	73429723	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:73429723A>G	ENST00000336083.3	-	4	679	c.224T>C	c.(223-225)tTc>tCc	p.F75S	RAB6A_ENST00000310653.6_Intron|RAB6A_ENST00000536566.1_Intron|RAB6A_ENST00000541588.1_Intron	NM_198896.1	NP_942599.1	P20340	RAB6A_HUMAN	RAB6A, member RAS oncogene family	75					minus-end-directed organelle transport along microtubule|peptidyl-cysteine methylation|protein targeting to Golgi|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic vesicle|cytosol|Golgi membrane|trans-Golgi network	GTP binding|GTPase activity|protein domain specific binding			large_intestine(2)|lung(2)	4						CAAGCTCCTGAACCGCTCTTG	0.403000													5	48					0	0	0.021553	0	0
PEX5L	51555	broad.mit.edu	37	3	179615934	179615934	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:179615934G>T	ENST00000467460.1	-	3	524	c.194C>A	c.(193-195)tCa>tAa	p.S65*	PEX5L_ENST00000464614.1_Nonsense_Mutation_p.S22*|PEX5L_ENST00000485199.1_Intron|PEX5L_ENST00000476138.1_Nonsense_Mutation_p.S22*|PEX5L_ENST00000472994.1_Intron|PEX5L_ENST00000468741.1_Intron|PEX5L_ENST00000465751.1_Nonsense_Mutation_p.S41*|PEX5L_ENST00000392649.3_Nonsense_Mutation_p.S22*|PEX5L_ENST00000263962.8_Nonsense_Mutation_p.S63*	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	65					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GCCCACCTGTGATGTCATAGT	0.433000													33	65					8.4185e-14	1.12805e-13	0.050027	1	0
ARID3C	138715	broad.mit.edu	37	9	34622422	34622422	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:34622422C>T	ENST00000378909.2	-	5	1062	c.970G>A	c.(970-972)Gtg>Atg	p.V324M		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	324	Pro-rich.|REKLES.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CCCATCAGCACAGCTCTCTTC	0.617000													10	14					0	0	0.058154	0	0
LRFN2	57497	broad.mit.edu	37	6	40400506	40400506	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:40400506C>A	ENST00000338305.6	-	2	889	c.347G>T	c.(346-348)gGg>gTg	p.G116V		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	116						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGTGTCCTCCCCAAGGCTTGG	0.592000													8	21					5.4927e-09	6.76095e-09	0.047766	1	0
KBTBD8	84541	broad.mit.edu	37	3	67053833	67053833	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:67053833G>T	ENST00000295568.4	+	3	495	c.364G>T	c.(364-366)Gac>Tac	p.D122Y	KBTBD8_ENST00000469661.1_Intron|KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000417314.2_Missense_Mutation_p.D148Y	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	148										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		CAGTCATTTGGACCCACAGAA	0.408000													12	79					3.07112e-06	3.56134e-06	0.080935	1	0
INHBA	3624	broad.mit.edu	37	7	41729829	41729829	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:41729829C>G	ENST00000242208.4	-	3	946	c.700G>C	c.(700-702)Ggc>Cgc	p.G234R	INHBA_ENST00000442711.1_Missense_Mutation_p.G234R|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000464515.1_5'UTR	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	234					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GAGCTCTTGCCCTGGTCCAGC	0.567000										TSP Lung(11;0.080)			5	44					0	0	0.021553	0	0
CCNB3	85417	broad.mit.edu	37	X	50053674	50053674	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:50053674G>A	ENST00000376042.1	+	6	2803	c.2505G>A	c.(2503-2505)gaG>gaA	p.E835E	CCNB3_ENST00000276014.7_Silent_p.E835E|CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	835					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CCTTGCAGGAGGAGCCCAGCA	0.537000													8	75					0	0	0.058154	0	0
KRT25	147183	broad.mit.edu	37	17	38907509	38907509	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:38907509C>G	ENST00000312150.4	-	4	799	c.739G>C	c.(739-741)Gac>Cac	p.D247H		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	247	Linker 12.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				ACTGTGAGGTCCACCCCGGGG	0.572000													13	55					0	0	0.024245	0	0
MT-ND4L	4539	broad.mit.edu	37	MT	10725	10725	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:10725G>A	ENST00000361335.1	+	1	256	c.256G>A	c.(256-258)Ggc>Agc	p.G86S						mitochondrially encoded NADH dehydrogenase 4L											breast(1)|endometrium(2)|kidney(2)	5						CCAACACATATGGCCTAGACT	0.443000													32	460					0	0	0.069456	0	0
ATP1B4	23439	broad.mit.edu	37	X	119509423	119509423	+	Splice_Site	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:119509423G>T	ENST00000218008.3	+	5	816	c.759_splice	c.e5+1	p.R253_splice	ATP1B4_ENST00000539306.1_Splice_Site_p.R210_splice|ATP1B4_ENST00000361319.3_Splice_Site_p.R249_splice	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	253					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						AGATGAACCGGGTATATTGGC	0.478000													39	119					4.32679e-17	6.10696e-17	0.092188	1	0
TKTL1	8277	broad.mit.edu	37	X	153541000	153541000	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:153541000T>A	ENST00000369915.3	+	6	929	c.740T>A	c.(739-741)tTa>tAa	p.L247*	TKTL1_ENST00000217905.7_Intron|TKTL1_ENST00000369912.2_Nonsense_Mutation_p.L191*	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	247					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity	p.K246fs*26(1)		NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATTATCAAATTAATTGAGAGC	0.448000													10	96					0	0	0.020292	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995886	57995886	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:57995886G>T	ENST00000316770.2	-	1	504	c.462C>A	c.(460-462)ggC>ggA	p.G154G		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				AGAGGGCCAGGCCCAGGGCCC	0.617000													33	58					1.22384e-17	1.73728e-17	0.054565	1	0
ADCK1	57143	broad.mit.edu	37	14	78353513	78353513	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:78353513A>T	ENST00000238561.5	+	5	602	c.503A>T	c.(502-504)cAt>cTt	p.H168L	ADCK1_ENST00000341211.5_Missense_Mutation_p.H100L	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	175	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GCAGTGCTGCATGATGGGCGG	0.607000													9	45					0	0	0.058154	0	0
CKMT2	1160	broad.mit.edu	37	5	80550258	80550258	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:80550258A>G	ENST00000424301.2	+	5	633	c.395A>G	c.(394-396)aAc>aGc	p.N132S	CTC-281B15.1_ENST00000505295.1_RNA|CKMT2_ENST00000254035.4_Missense_Mutation_p.N132S|CTC-281B15.1_ENST00000511495.1_RNA|CKMT2_ENST00000437669.1_Missense_Mutation_p.N132S|CTC-281B15.1_ENST00000500148.2_RNA|CTC-281B15.1_ENST00000501927.2_RNA|CTC-281B15.1_ENST00000512287.1_RNA|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000503483.2_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	132	Phosphagen kinase N-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	CTAAGACACAACGGCTATGAC	0.512000													10	34					0	0	0.093190	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222201	140222201	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140222201C>G	ENST00000531613.1	+	1	1295	c.1295C>G	c.(1294-1296)tCg>tGg	p.S432W	PCDHA8_ENST00000378123.3_Missense_Mutation_p.S432W|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCGCTG	0.632000													17	18					0	0	0.049695	0	0
SACS	26278	broad.mit.edu	37	13	23915047	23915047	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:23915047T>A	ENST00000382298.3	-	10	3556	c.2968A>T	c.(2968-2970)Agc>Tgc	p.S990C	SACS_ENST00000402364.1_Missense_Mutation_p.S240C|SACS_ENST00000382292.3_Missense_Mutation_p.S990C	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	990					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTTAAGCAGCTAGTGGTCTTT	0.358000													18	17					0	0	0.038395	0	0
SERPINE2	5270	broad.mit.edu	37	2	224866368	224866368	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:224866368C>T	ENST00000409840.3	-	3	910	c.250G>A	c.(250-252)Ggc>Agc	p.G84S	SERPINE2_ENST00000447280.2_Missense_Mutation_p.G96S|SERPINE2_ENST00000409304.1_Missense_Mutation_p.G84S|SERPINE2_ENST00000258405.4_Missense_Mutation_p.G84S			P07093	GDN_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	84					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	17		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CCATTTACGCCGTATCTCATC	0.567000													17	81					0	0	0.038395	0	0
SEMA5A	9037	broad.mit.edu	37	5	9337878	9337878	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:9337878A>T	ENST00000382496.5	-	4	836	c.171T>A	c.(169-171)gaT>gaA	p.D57E		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	57	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						ACTGCGAGAAATCCACAGCAT	0.353000													23	45					0	0	0.076483	0	0
DCAF6	55827	broad.mit.edu	37	1	167960554	167960554	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:167960554G>A	ENST00000367840.3	+	6	759	c.665G>A	c.(664-666)cGa>cAa	p.R222Q	DCAF6_ENST00000432587.2_Missense_Mutation_p.R191Q|DCAF6_ENST00000367843.3_Missense_Mutation_p.R222Q|DCAF6_ENST00000470919.1_3'UTR|DCAF6_ENST00000312263.6_Missense_Mutation_p.R222Q	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	222					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						TATGATCGGCGAATGCTGGGC	0.398000													15	51					0	0	0.020292	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576995	158576995	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:158576995C>T	ENST00000361284.1	+	1	767	c.767C>T	c.(766-768)tCc>tTc	p.S256F		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GGCTGTGCTTCCTTCGTGTAC	0.507000													60	443					0	0	0.048971	0	0
LINC01317	104355287	broad.mit.edu	37	2	33952708	33952708	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:33952708G>T	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							GCAAGTAGGTGGTGGGGTAGA	0.622000													10	57					0.00010058	0.000112075	0.093190	1	0
SPATA31D5P	347127	broad.mit.edu	37	9	84534432	84534432	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:84534432C>A	ENST00000527857.1	+	0	4454					NR_026851.1																						CCAGGGCTATCCCCGCAACTA	0.498000													13	33					1.5842e-08	1.94353e-08	0.105934	1	0
COL19A1	1310	broad.mit.edu	37	6	70744137	70744137	+	Splice_Site	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:70744137G>T	ENST00000322773.4	+	13	1183	c.1080_splice	c.e13-1	p.G361_splice		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	361			G -> D (in a breast cancer sample; somatic mutation).		cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CTTTCTACAGGGTTTGAAAGG	0.373000													20	18					1.37657e-19	2.00794e-19	0.062417	1	0
SLC25A31	83447	broad.mit.edu	37	4	128694602	128694602	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:128694602A>T	ENST00000281154.4	+	6	989	c.821A>T	c.(820-822)cAt>cTt	p.H274L		NM_031291.2	NP_112581.1	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31	274					transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity			NS(1)|breast(1)|large_intestine(10)|lung(8)|skin(2)	22						ATATACCAACATGAAGGAATC	0.383000													3	43					0	0	0.004672	0	0
NF1	4763	broad.mit.edu	37	17	29654664	29654664	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:29654664C>T	ENST00000358273.4	+	38	5799	c.5416C>T	c.(5416-5418)Cag>Tag	p.Q1806*	NF1_ENST00000356175.3_Nonsense_Mutation_p.Q1785*|NF1_ENST00000581113.2_3'UTR	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1806					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CATTGCAAACCAGGGCACGCC	0.473000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			41	91					0	0	0.042209	0	0
CDH6	1004	broad.mit.edu	37	5	31316365	31316365	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:31316365G>A	ENST00000265071.2	+	9	1706	c.1441G>A	c.(1441-1443)Gtc>Atc	p.V481I	CDH6_ENST00000514738.1_Missense_Mutation_p.V426I	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	481	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGTTCTAGATGTCAATGACAA	0.348000													5	62					0	0	0.021553	0	0
FLG	2312	broad.mit.edu	37	1	152283465	152283465	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152283465C>T	ENST00000368799.1	-	3	3932	c.3897G>A	c.(3895-3897)cgG>cgA	p.R1299R	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1299	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ttgactgctcccgagaagatc	0.547000									Ichthyosis				55	153					0	0	0.048971	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857515	101857515	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:101857515G>C	ENST00000604957.1	+	1	3068	c.446G>C	c.(445-447)aGa>aCa	p.R149T	ARMCX5_ENST00000246174.2_Missense_Mutation_p.R149T|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000537008.1_Missense_Mutation_p.R149T|RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000541409.1_Missense_Mutation_p.R149T|ARMCX5_ENST00000536530.1_Missense_Mutation_p.R149T|ARMCX5_ENST00000372742.1_Missense_Mutation_p.R149T	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	149							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						ACTGGGTCCAGACCTGACAGA	0.453000													9	931					0	0	0.080935	0	0
ARAP2	116984	broad.mit.edu	37	4	36231049	36231049	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:36231049C>G	ENST00000303965.4	-	2	549	c.60G>C	c.(58-60)ttG>ttC	p.L20F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	20	SAM.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GATACTGCTCCAAATTAATGC	0.378000													44	66					0	0	0.048971	0	0
RHBDF1	64285	broad.mit.edu	37	16	108670	108670	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:108670C>T	ENST00000262316.6	-	18	2379	c.2237G>A	c.(2236-2238)cGt>cAt	p.R746H		NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	746					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GAAGAAGGCACGCCAGGGCCG	0.617000													5	8					0	0	0.021553	0	0
NFE2L2	4780	broad.mit.edu	37	2	178096096	178096096	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:178096096C>A	ENST00000397062.3	-	5	1789	c.1235G>T	c.(1234-1236)gGg>gTg	p.G412V	NFE2L2_ENST00000464747.1_Missense_Mutation_p.G396V|NFE2L2_ENST00000446151.2_Missense_Mutation_p.G389V|NFE2L2_ENST00000397063.4_Missense_Mutation_p.G396V	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	412					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AGTGCTCTGCCCCTGAGATGG	0.473000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			53	87					1.27862e-28	1.98628e-28	0.048971	1	0
CHRND	1144	broad.mit.edu	37	2	233394818	233394818	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:233394818G>T	ENST00000258385.3	+	7	821	c.789G>T	c.(787-789)atG>atT	p.M263I	CHRND_ENST00000457943.2_Intron|CHRND_ENST00000543200.1_Missense_Mutation_p.M248I|CHRND_ENST00000536614.1_Missense_Mutation_p.G227C	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	263					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		TCTCCTTCATGGTCAACCTGG	0.632000													8	20					0.000157383	0.000174582	0.038147	1	0
CLHC1	130162	broad.mit.edu	37	2	55436623	55436623	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:55436623G>T	ENST00000401408.1	-	7	1076	c.731C>A	c.(730-732)gCa>gAa	p.A244E	CLHC1_ENST00000494539.1_Intron|CLHC1_ENST00000406076.1_Missense_Mutation_p.A122E|CLHC1_ENST00000407122.1_Missense_Mutation_p.A244E|CLHC1_ENST00000406437.2_Intron	NM_152385.2	NP_689598.2			clathrin heavy chain linker domain containing 1																		TGAACTAAGTGCCTGTGAAAT	0.318000													15	73					1.5739e-10	2.00733e-10	0.028581	1	0
PLXNA3	55558	broad.mit.edu	37	X	153688886	153688886	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:153688886G>T	ENST00000369682.3	+	2	538	c.363G>T	c.(361-363)caG>caT	p.Q121H		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	121	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCATCTGCCAGTTCCTGCGTC	0.657000													16	8					1.64293e-13	2.19354e-13	0.083992	1	0
CNBD1	168975	broad.mit.edu	37	8	87878769	87878769	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:87878769G>T	ENST00000518476.1	+	1	97	c.46G>T	c.(46-48)Gct>Tct	p.A16S		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	16										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TCACATGACAGCTATTAACAA	0.443000													42	41					5.34276e-22	7.90216e-22	0.048971	1	0
AMER1	139285	broad.mit.edu	37	X	63411303	63411303	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:63411303C>G	ENST00000330258.3	-	2	2136	c.1864G>C	c.(1864-1866)Gag>Cag	p.E622Q	AMER1_ENST00000374869.3_Missense_Mutation_p.E622Q|AMER1_ENST00000403336.1_Missense_Mutation_p.E622Q	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									GTTCTGGCCTCCCTGCCATGA	0.617000													10	39					0	0	0.028581	0	0
FXN	2395	broad.mit.edu	37	9	71687583	71687583	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:71687583G>A	ENST00000377270.3	+	5	1062	c.538G>A	c.(538-540)Gtg>Atg	p.V180M	FXN_ENST00000396366.2_Silent_p.A182A|FXN_ENST00000498653.1_Missense_Mutation_p.V105M|FXN_ENST00000396364.3_Intron	NM_000144.4	NP_000135.2	Q16595	FRDA_HUMAN	frataxin	180					cellular iron ion homeostasis|cellular response to hydrogen peroxide|heme biosynthetic process|ion transport|iron incorporation into metallo-sulfur cluster|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity|protein autoprocessing|regulation of ferrochelatase activity|response to iron ion	cytosol|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferric iron binding|ferrous iron binding|ferroxidase activity|iron chaperone activity|protein binding			large_intestine(1)|lung(1)	2						CCACGACGGCGTGTCCCTCCA	0.502000													15	47					0	0	0.033300	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105360972	105360972	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:105360972C>T	ENST00000297581.2	+	2	241	c.192C>T	c.(190-192)tcC>tcT	p.S64S	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Silent_p.S64S	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	64					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											CCGCTGCCTCCTGGATTATCA	0.507000													61	63					0	0	0.048971	0	0
CCDC97	90324	broad.mit.edu	37	19	41822539	41822539	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:41822539G>T	ENST00000269967.3	+	2	419	c.297G>T	c.(295-297)ctG>ctT	p.L99L		NM_052848.1	NP_443080.1	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	99										biliary_tract(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	17						TGGCCCAGCTGTACCACGAGA	0.642000													11	7					0.00244969	0.00260808	0.020292	1	0
GIMAP1	170575	broad.mit.edu	37	7	150417174	150417174	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:150417174C>T	ENST00000307194.5	+	3	222	c.82C>T	c.(82-84)Cgg>Tgg	p.R28W		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGTCCACGCGGAGGCTCAT	0.557000													162	250					0	0	0.048971	0	0
NCOA6	23054	broad.mit.edu	37	20	33329685	33329685	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:33329685T>C	ENST00000374796.2	-	12	6945	c.4375A>G	c.(4375-4377)Aaa>Gaa	p.K1459E	NCOA6_ENST00000359003.2_Missense_Mutation_p.K1459E			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1459					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CCATCCTTTTTGGACTGATCT	0.448000													22	50					0	0	0.076483	0	0
ATP4A	495	broad.mit.edu	37	19	36045890	36045890	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:36045890G>T	ENST00000262623.3	-	16	2443	c.2415C>A	c.(2413-2415)atC>atA	p.I805I		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	805					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGCTGACGGTGATGTAGATGA	0.547000													15	37					2.23348e-06	2.59406e-06	0.028581	1	0
MYO3A	53904	broad.mit.edu	37	10	26305791	26305791	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:26305791C>T	ENST00000265944.5	+	7	717	c.551C>T	c.(550-552)aCa>aTa	p.T184I	MYO3A_ENST00000376301.1_Missense_Mutation_p.T184I|MYO3A_ENST00000376302.1_Missense_Mutation_p.T184I|MYO3A_ENST00000543632.1_Missense_Mutation_p.T184I	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	184	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CGTCGGAACACATCCGTAGGA	0.438000													12	86					0	0	0.024245	0	0
FLG	2312	broad.mit.edu	37	1	152279609	152279609	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152279609C>A	ENST00000368799.1	-	3	7788	c.7753G>T	c.(7753-7755)Ggg>Tgg	p.G2585W	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2585	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAGCAGACCCAGACCACCTC	0.557000									Ichthyosis				86	108					2.07442e-65	3.46986e-65	0.048971	1	0
AWAT1	158833	broad.mit.edu	37	X	69455988	69455988	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:69455988C>A	ENST00000374521.3	+	3	295	c.255_splice	c.e3+1	p.T85_splice	AWAT1_ENST00000480702.1_3'UTR	NM_001013579.2	NP_001013597.1	Q58HT5	AWAT1_HUMAN	acyl-CoA wax alcohol acyltransferase 1	85					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity	p.T165M(1)		breast(2)|central_nervous_system(1)|large_intestine(4)|lung(3)|ovary(4)|skin(1)	15						TTCCCCATTACGGTAAGTATC	0.483000													79	129					3.90494e-43	6.38756e-43	0.048971	1	0
MUC17	140453	broad.mit.edu	37	7	100682595	100682595	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:100682595C>G	ENST00000306151.4	+	3	7962	c.7898C>G	c.(7897-7899)aCt>aGt	p.T2633S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2633	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGTAAGTACTTCATTAACA	0.463000													33	105					0	0	0.054565	0	0
C4orf21	55345	broad.mit.edu	37	4	113541202	113541202	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:113541202G>A	ENST00000505019.1	-	5	432	c.307C>T	c.(307-309)Cga>Tga	p.R103*	C4orf21_ENST00000445203.2_Nonsense_Mutation_p.R72*|C4orf21_ENST00000309071.5_Nonsense_Mutation_p.R103*	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	103										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		CCAAGAGATCGGCCAGAGGAT	0.343000													4	55					0	0	0.009096	0	0
ZNF430	80264	broad.mit.edu	37	19	21240404	21240404	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:21240404A>T	ENST00000261560.5	+	5	1471	c.1290A>T	c.(1288-1290)aaA>aaT	p.K430N		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						AACCCTACAAATGTGAACAAT	0.373000													17	22					0	0	0.033300	0	0
WBP11P1	441818	broad.mit.edu	37	18	30091879	30091879	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:30091879C>A	ENST00000567636.1	+	0	254					NR_003558.1																						ACCCCACAGACCAAGCCCGAA	0.398000													24	29					9.04412e-07	1.06376e-06	0.099896	1	0
ENPEP	2028	broad.mit.edu	37	4	111470556	111470556	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:111470556G>T	ENST00000265162.5	+	15	2548	c.2206G>T	c.(2206-2208)Gct>Tct	p.A736S		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	736					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ATGGAATGATGCTGGAGACCA	0.318000													38	15					9.84934e-19	1.42825e-18	0.039052	1	0
ABCG8	64241	broad.mit.edu	37	2	44079549	44079549	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:44079549C>A	ENST00000272286.2	+	5	708	c.618C>A	c.(616-618)ggC>ggA	p.G206G		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	206	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CCCGCGTGGGCAACATGTACG	0.667000													12	17					0.00136819	0.00147145	0.093190	1	0
NR4A3	8013	broad.mit.edu	37	9	102595773	102595773	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:102595773C>T	ENST00000338488.4	+	5	2020	c.1291C>T	c.(1291-1293)Cag>Tag	p.Q431*	NR4A3_ENST00000395097.2_Intron|NR4A3_ENST00000330847.1_Intron	NM_173199.2	NP_775291.1	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	0					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AATGAATGATCAGGGTCTCTA	0.363000			T	EWSR1	extraskeletal myxoid chondrosarcoma								7	43					0	0	0.105934	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731490	140731490	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140731490G>T	ENST00000523390.1	+	1	1663	c.1663G>T	c.(1663-1665)Gcg>Tcg	p.A555S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATGACAATGCGCCACGGGT	0.692000													22	13					2.44723e-14	3.32124e-14	0.099896	1	0
ZNF532	55205	broad.mit.edu	37	18	56651651	56651651	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:56651651G>A	ENST00000336078.4	+	11	4635	c.3859G>A	c.(3859-3861)Ggc>Agc	p.G1287S	ZNF532_ENST00000589288.1_Missense_Mutation_p.G1287S|ZNF532_ENST00000588956.1_3'UTR|ZNF532_ENST00000591230.1_Missense_Mutation_p.G1287S|ZNF532_ENST00000591083.1_Missense_Mutation_p.G1287S|ZNF532_ENST00000591808.1_Missense_Mutation_p.G1287S	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						GCGGACACACGGCATGGCCTT	0.463000													8	35					0	0	0.093190	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67220986	67220986	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:67220986C>G	ENST00000314586.6	-	6	1336	c.1096G>C	c.(1096-1098)Gag>Cag	p.E366Q	EXOC3L1_ENST00000562887.1_5'UTR	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	366	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						AGAAGGGGCTCCAGCTGGGAC	0.572000													9	14					0	0	0.047766	0	0
LDHD	197257	broad.mit.edu	37	16	75147927	75147927	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:75147927C>A	ENST00000300051.4	-	6	881	c.835G>T	c.(835-837)Gtc>Ttc	p.V279F	LDHD_ENST00000450168.2_Missense_Mutation_p.V256F	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	279							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						GCAGCCTGGACACTGGGGAAC	0.682000													3	12					0.004672	0.00493156	0.004672	1	0
ALDH1B1	219	broad.mit.edu	37	9	38396745	38396745	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:38396745G>T	ENST00000377698.3	+	2	1153	c.1000G>T	c.(1000-1002)Gag>Tag	p.E334*		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	334					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CATCTACAATGAGTTTCTCGA	0.572000													17	17					0.000566183	0.000622465	0.033300	1	0
CMKLR1	1240	broad.mit.edu	37	12	108686630	108686630	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:108686630C>A	ENST00000312143.7	-	3	473	c.110G>T	c.(109-111)aGg>aTg	p.R37M	CMKLR1_ENST00000550402.1_Missense_Mutation_p.R37M|CMKLR1_ENST00000412676.1_Missense_Mutation_p.R37M|CMKLR1_ENST00000397688.2_Missense_Mutation_p.R35M|CMKLR1_ENST00000552995.1_Missense_Mutation_p.R35M	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	37					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						CCTGGTCACCCTGGCTTCCAA	0.483000													54	28					2.27459e-33	3.61689e-33	0.048971	1	0
ZNF253	56242	broad.mit.edu	37	19	20003006	20003006	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:20003006G>T	ENST00000589717.1	+	4	1042	c.950G>T	c.(949-951)tGt>tTt	p.C317F	ZNF253_ENST00000355650.4_Missense_Mutation_p.C241F	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	317				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGTGAAGAATGTGGCAAATCC	0.398000													11	32					1.58986e-06	1.86112e-06	0.069234	1	0
HEMGN	55363	broad.mit.edu	37	9	100689761	100689761	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:100689761C>A	ENST00000259456.3	-	5	1504		c.e5-1			NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen						cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				TCTTTCATTTCTGTAAAATCA	0.303000													5	17					0.00116845	0.00126213	0.021553	1	0
SRSF9	8683	broad.mit.edu	37	12	120901792	120901792	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:120901792G>A	ENST00000229390.3	-	3	666	c.483C>T	c.(481-483)gcC>gcT	p.A161A		NM_003769.2	NP_003760.1	Q13242	SRSF9_HUMAN	serine/arginine-rich splicing factor 9	161	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	9						GTTTACGCAGGGCATATTCCA	0.488000													23	42					0	0	0.083992	0	0
TMEM144	55314	broad.mit.edu	37	4	159156650	159156650	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:159156650C>T	ENST00000296529.6	+	8	1076	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C	TMEM144_ENST00000503404.1_3'UTR	NM_018342.4	NP_060812.2	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	186						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(7)|lung(9)|prostate(1)	19	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		AGTACACCACCGCATAGTGTA	0.388000													9	45					0	0	0.069234	0	0
OGT	8473	broad.mit.edu	37	X	70777049	70777049	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:70777049C>G	ENST00000373719.3	+	11	1542	c.1325C>G	c.(1324-1326)tCa>tGa	p.S442*	OGT_ENST00000373701.3_Nonsense_Mutation_p.S432*	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	442					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					TTCCAGGATTCAGGGAATATT	0.358000													13	20					0	0	0.105934	0	0
USHBP1	83878	broad.mit.edu	37	19	17370140	17370140	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:17370140C>T	ENST00000252597.3	-	7	1177	c.1004G>A	c.(1003-1005)cGg>cAg	p.R335Q	USHBP1_ENST00000431146.2_Missense_Mutation_p.R271Q	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	335							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						CTCAGCCTCCCGCTGGCCTAG	0.567000													5	16					0	0	0.021553	0	0
FLG2	388698	broad.mit.edu	37	1	152327811	152327811	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152327811G>A	ENST00000388718.5	-	3	2523	c.2451C>T	c.(2449-2451)tcC>tcT	p.S817S	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	817	Ser-rich.						calcium ion binding|structural molecule activity	p.S817S(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAAAGCCAGCGGACTGACCTG	0.522000													75	509					0	0	0.048971	0	0
COL11A1	1301	broad.mit.edu	37	1	103544265	103544265	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:103544265G>A	ENST00000358392.2	-	3	754	c.437C>T	c.(436-438)cCt>cTt	p.P146L	COL11A1_ENST00000370096.3_Missense_Mutation_p.P146L|COL11A1_ENST00000353414.4_Missense_Mutation_p.P146L|COL11A1_ENST00000512756.1_Missense_Mutation_p.P146L	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	146	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCTGGGGCAGGTTTTCCAGT	0.373000													10	38					0	0	0.080935	0	0
NUMA1	4926	broad.mit.edu	37	11	71715082	71715082	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:71715082G>C	ENST00000393695.3	-	26	6518	c.6187C>G	c.(6187-6189)Ctt>Gtt	p.L2063V	NUMA1_ENST00000351960.6_Missense_Mutation_p.L927V|NUMA1_ENST00000358965.6_Missense_Mutation_p.L2049V	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	2063					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CGCCGCAGAAGGCTGTTCCCT	0.632000			T	RARA	APL								16	46					0	0	0.062417	0	0
FSTL5	56884	broad.mit.edu	37	4	162463754	162463754	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:162463754C>A	ENST00000306100.5	-	9	1543	c.1107G>T	c.(1105-1107)aaG>aaT	p.K369N	FSTL5_ENST00000511170.1_Intron|FSTL5_ENST00000427802.2_Missense_Mutation_p.K368N|FSTL5_ENST00000536695.1_Missense_Mutation_p.K368N|FSTL5_ENST00000379164.4_Missense_Mutation_p.K368N	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	369	Ig-like 2.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CAAGCTGAGGCTTTGGTATGC	0.458000													29	91					6.38683e-12	8.31747e-12	0.037714	1	0
CALHM1	255022	broad.mit.edu	37	10	105215148	105215148	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:105215148C>A	ENST00000329905.5	-	2	1048	c.912G>T	c.(910-912)acG>acT	p.T304T	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	304						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						TGTGCCAGCTCGTGAGCAGCC	0.677000													6	1					0.00829132	0.00870236	0.069234	1	0
FRMPD4	9758	broad.mit.edu	37	X	12722586	12722586	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:12722586G>C	ENST00000380682.1	+	11	1685	c.1179G>C	c.(1177-1179)ttG>ttC	p.L393F		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	393	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						ATCAAAACTTGGTACCACCGG	0.353000													50	67					0	0	0.048971	0	0
CCDC42	146849	broad.mit.edu	37	17	8644891	8644891	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:8644891C>G	ENST00000293845.3	-	4	619	c.393G>C	c.(391-393)gaG>gaC	p.E131D	CCDC42_ENST00000539522.2_Missense_Mutation_p.E131D	NM_144681.2	NP_653282.2	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42	131										kidney(1)|large_intestine(4)|lung(3)|ovary(1)	9						GCGCCACCATCTCCTGCTTGC	0.572000													16	8					0	0	0.034045	0	0
CCNB3	85417	broad.mit.edu	37	X	50089666	50089666	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:50089666C>A	ENST00000376042.1	+	10	3968	c.3670C>A	c.(3670-3672)Cgt>Agt	p.R1224S	CCNB3_ENST00000276014.7_Missense_Mutation_p.R1224S|CCNB3_ENST00000348603.2_Missense_Mutation_p.R120S|CCNB3_ENST00000376038.1_Missense_Mutation_p.R120S			Q8WWL7	CCNB3_HUMAN	cyclin B3	1224					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CAACTCACCTCGTGTGGATGA	0.463000													152	75					2.11632e-91	3.58035e-91	0.048971	1	0
ZNF454	285676	broad.mit.edu	37	5	178391871	178391871	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:178391871G>C	ENST00000320129.3	+	5	769	c.466G>C	c.(466-468)Ggg>Cgg	p.G156R	ZNF454_ENST00000519564.1_Missense_Mutation_p.G156R	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TGATGAATCCGGGAGCACTAT	0.488000													7	29					0	0	0.047766	0	0
RGS4	5999	broad.mit.edu	37	1	163039311	163039311	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:163039311T>G	ENST00000421743.2	+	2	488	c.328T>G	c.(328-330)Ttg>Gtg	p.L110V	RGS4_ENST00000527809.1_Intron|RGS4_ENST00000367909.6_Missense_Mutation_p.L13V|RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000367908.4_Missense_Mutation_p.L13V|RGS4_ENST00000531057.1_Missense_Mutation_p.L13V	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	13	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						GGCTTCTTGCTTGAGGAGGTA	0.438000											OREG0013952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	70					0	0	0.069456	0	0
SLC30A9	10463	broad.mit.edu	37	4	42072578	42072578	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:42072578G>T	ENST00000264451.6	+	15	1468	c.1288G>T	c.(1288-1290)Gtg>Ttg	p.V430L		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	430					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTCTTTGGGTGTGGGCACCTT	0.413000													11	48					0.0202918	0.0210297	0.020292	1	0
EVX2	344191	broad.mit.edu	37	2	176948324	176948324	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:176948324C>T	ENST00000308618.4	-	1	317	c.181G>A	c.(181-183)Gct>Act	p.A61T		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	61						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.A61T(1)		kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		TCTCCCAGAGCGCTGTGCAGG	0.607000													6	19					0	0	0.021553	0	0
MAP3K9	4293	broad.mit.edu	37	14	71199705	71199705	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:71199705C>A	ENST00000554752.2	-	11	2380	c.2381G>T	c.(2380-2382)cGg>cTg	p.R794L	MAP3K9_ENST00000555993.2_Missense_Mutation_p.R808L|MAP3K9_ENST00000381250.4_Missense_Mutation_p.R771L|MAP3K9_ENST00000553414.1_Missense_Mutation_p.R527L|MAP3K9_ENST00000554146.1_Missense_Mutation_p.R522L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	794					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.R808Q(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		AAGACCCTCCCGTCTTTTCTT	0.607000													16	25					2.4624e-09	3.05634e-09	0.049695	1	0
PCDHA1	56147	broad.mit.edu	37	5	140166174	140166174	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140166174C>T	ENST00000504120.2	+	1	299	c.299C>T	c.(298-300)gCg>gTg	p.A100V	PCDHA1_ENST00000378133.3_Missense_Mutation_p.A100V|PCDHA1_ENST00000394633.3_Missense_Mutation_p.A100V	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGGAGCGCGGAGTGCAGC	0.532000													21	28					0	0	0.069288	0	0
OR5AN1	390195	broad.mit.edu	37	11	59132851	59132851	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:59132851A>G	ENST00000313940.2	+	1	967	c.920A>G	c.(919-921)aAg>aGg	p.K307R		NM_001004729.1	NP_001004729.1	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	21						AGGTTGCAAAAGAGAAAGTGC	0.373000													14	30					0	0	0.020292	0	0
ARMCX3	51566	broad.mit.edu	37	X	100880242	100880242	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:100880242G>T	ENST00000341189.4	+	5	1139	c.273G>T	c.(271-273)agG>agT	p.R91S	ARMCX3_ENST00000471229.2_Missense_Mutation_p.R91S|ARMCX3_ENST00000537169.1_Missense_Mutation_p.R91S	NM_016607.3	NP_057691.1	Q9UH62	ARMX3_HUMAN	armadillo repeat containing, X-linked 3	91						integral to membrane	binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11						CCagagctagggccagggcaa	0.547000													120	145					4.35912e-55	7.21007e-55	0.048971	1	0
SLC39A12	221074	broad.mit.edu	37	10	18284617	18284617	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:18284617G>C	ENST00000377369.2	+	10	1839	c.1566G>C	c.(1564-1566)atG>atC	p.M522I	SLC39A12_ENST00000377374.4_Missense_Mutation_p.M485I|SLC39A12_ENST00000539911.1_Missense_Mutation_p.M388I|SLC39A12_ENST00000377371.3_Missense_Mutation_p.M521I	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	522					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CAGCTGAAATGCCTATAGGCA	0.333000													20	48					0	0	0.076483	0	0
UBQLN4	56893	broad.mit.edu	37	1	156011313	156011313	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:156011313T>A	ENST00000368309.3	-	10	1708	c.1616A>T	c.(1615-1617)cAg>cTg	p.Q539L	UBQLN4_ENST00000368307.1_Silent_p.A191A	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	539						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					CTGGATCATCTGCTGCATGAG	0.597000													10	39					0	0	0.028581	0	0
PAGE5	90737	broad.mit.edu	37	X	55248206	55248206	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:55248206C>G	ENST00000289619.5	+	3	393	c.148C>G	c.(148-150)Cag>Gag	p.Q50E	PAGE5_ENST00000374955.3_Missense_Mutation_p.Q30E|PAGE5_ENST00000374952.1_Missense_Mutation_p.Q30E	NM_130467.3	NP_569734.2	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 (prostate associated)	50										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						TTAGGTCCAGCAGCCCACTGA	0.408000													3	83					0	0	0.009096	0	0
PLXDC2	84898	broad.mit.edu	37	10	20534306	20534306	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:20534306G>A	ENST00000377252.3	+	13	2186	c.1345G>A	c.(1345-1347)Ggg>Agg	p.G449R	PLXDC2_ENST00000377242.3_Missense_Mutation_p.G400R|PLXDC2_ENST00000377238.2_3'UTR	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	449						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						TGAGAAGAAAGGGGGAACCCT	0.483000													10	75					0	0	0.058154	0	0
DGKB	1607	broad.mit.edu	37	7	14722411	14722411	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:14722411G>A	ENST00000403951.2	-	11	1304	c.885C>T	c.(883-885)atC>atT	p.I295I	DGKB_ENST00000407950.1_Silent_p.I288I|DGKB_ENST00000406247.3_Silent_p.I295I|DGKB_ENST00000402815.1_Silent_p.I295I|DGKB_ENST00000399322.3_Silent_p.I295I|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Silent_p.I295I|DGKB_ENST00000444700.2_Silent_p.I288I			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	295					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CATAGGTCTTGATGCAAGAGG	0.463000													20	26					0	0	0.049695	0	0
CLASP2	23122	broad.mit.edu	37	3	33540177	33540177	+	Silent	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:33540177T>G	ENST00000399362.4	-	39	4841	c.4488A>C	c.(4486-4488)gcA>gcC	p.A1496A	CLASP2_ENST00000468888.2_Silent_p.A1497A|CLASP2_ENST00000539981.1_3'UTR|CLASP2_ENST00000461133.3_Silent_p.A1256A|CLASP2_ENST00000359576.5_Silent_p.A1488A|CLASP2_ENST00000307312.7_Silent_p.A978A|CLASP2_ENST00000480013.1_Silent_p.A1276A	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	1498										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						AACCTGTTTGTGCACGTTTGA	0.398000													19	76					0	0	0.069288	0	0
TRPM8	79054	broad.mit.edu	37	2	234878399	234878399	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:234878399A>T	ENST00000324695.4	+	16	2126	c.2086A>T	c.(2086-2088)Atc>Ttc	p.I696F	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	696						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTGGAAGATTATCCTGTGTCT	0.418000													25	97					0	0	0.037714	0	0
OR8B2	26595	broad.mit.edu	37	11	124253105	124253105	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:124253105C>A	ENST00000375013.2	-	1	153	c.135G>T	c.(133-135)ttG>ttT	p.L45F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAAGAGTGATCAAGCCAAGGT	0.423000													40	352					1.38658e-30	2.17681e-30	0.048971	1	0
LHX8	431707	broad.mit.edu	37	1	75602868	75602868	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:75602868C>T	ENST00000294638.5	+	4	853	c.189C>T	c.(187-189)gcC>gcT	p.A63A	LHX8_ENST00000356261.3_Silent_p.A53A|LHX8_ENST00000559413.1_3'UTR	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	63						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						GGTCCATGGCCTCGGGCTCCG	0.677000													3	7					0	0	0.004672	0	0
ABTB2	25841	broad.mit.edu	37	11	34182595	34182595	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:34182595G>C	ENST00000435224.2	-	11	2676	c.2252C>G	c.(2251-2253)tCt>tGt	p.S751C	ABTB2_ENST00000298992.2_Missense_Mutation_p.S565C	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	565							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				GGTCCTCAGAGACTCGATCCA	0.632000													4	11					0	0	0.009096	0	0
IQSEC2	23096	broad.mit.edu	37	X	53267402	53267402	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:53267402C>A	ENST00000396435.3	-	12	3402	c.3202G>T	c.(3202-3204)Gac>Tac	p.D1068Y	IQSEC2_ENST00000375368.5_Missense_Mutation_p.D1058Y|IQSEC2_ENST00000375365.2_Missense_Mutation_p.D863Y	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	1058	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						CGCAGCCGGTCCTGGAGGCTG	0.562000													29	28					7.16026e-08	8.65539e-08	0.050027	1	0
LONRF3	79836	broad.mit.edu	37	X	118123451	118123451	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:118123451T>A	ENST00000365713.2	+	3	1180	c.1017T>A	c.(1015-1017)gcT>gcA	p.A339A	LONRF3_ENST00000371628.3_Silent_p.A380A|LONRF3_ENST00000304778.7_Silent_p.A339A|LONRF3_ENST00000472173.1_3'UTR|LONRF3_ENST00000422289.2_Silent_p.A124A			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	380					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						TGGACCCAGCTAAAGTGAAGG	0.542000													17	124					0	0	0.028581	0	0
OR2T10	127069	broad.mit.edu	37	1	248756858	248756858	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:248756858A>T	ENST00000330500.2	-	1	242	c.212T>A	c.(211-213)tTg>tAg	p.L71*		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATATATGTCAAGTCTATGAG	0.448000													13	39					0	0	0.020292	0	0
UGT3A1	133688	broad.mit.edu	37	5	35988626	35988626	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:35988626C>A	ENST00000274278.3	-	2	479	c.122G>T	c.(121-123)cGg>cTg	p.R41L	UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000333811.4_5'UTR|UGT3A1_ENST00000503189.1_Missense_Mutation_p.R41L|UGT3A1_ENST00000507113.1_Intron	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	41						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTGAGACACCCGGTCCAACAG	0.373000													27	73					3.90053e-15	5.35239e-15	0.050027	1	0
EMR1	2015	broad.mit.edu	37	19	6921811	6921811	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:6921811C>A	ENST00000312053.4	+	14	1745	c.1708C>A	c.(1708-1710)Ctg>Atg	p.L570M	EMR1_ENST00000250572.8_Missense_Mutation_p.L570M|EMR1_ENST00000381404.4_Missense_Mutation_p.L518M|EMR1_ENST00000450315.3_Missense_Mutation_p.L393M|EMR1_ENST00000381407.5_Missense_Mutation_p.L429M	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	570	GPS.|Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTGTGTGATCCTGGAAGCTTC	0.468000													68	62					3.58576e-35	5.73877e-35	0.048971	1	0
UNC5C	8633	broad.mit.edu	37	4	96091363	96091363	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:96091363C>T	ENST00000453304.1	-	15	2920	c.2572G>A	c.(2572-2574)Gcc>Acc	p.A858T		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	858	Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GTCTGGGGGGCATCCAGGCTG	0.597000													85	162					0	0	0.048971	0	0
KDR	3791	broad.mit.edu	37	4	55972875	55972875	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:55972875A>G	ENST00000263923.4	-	11	1810	c.1515T>C	c.(1513-1515)gcT>gcC	p.A505A		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	505	Ig-like C2-type 5.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CTTCAATTAGAGCAAATTGAT	0.343000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			16	54					0	0	0.024245	0	0
CNTN4	152330	broad.mit.edu	37	3	2778014	2778014	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:2778014A>T	ENST00000397461.1	+	4	555	c.171A>T	c.(169-171)aaA>aaT	p.K57N	CNTN4_ENST00000418658.1_Missense_Mutation_p.K57N|CNTN4_ENST00000427331.1_Missense_Mutation_p.K57N	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	57	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GAAATCCAAAACCTCATATCA	0.333000													15	24					0	0	0.024245	0	0
DTNA	1837	broad.mit.edu	37	18	32335960	32335960	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:32335960A>C	ENST00000283365.9	+	3	371	c.20A>C	c.(19-21)aAa>aCa	p.K7T	DTNA_ENST00000598142.1_Missense_Mutation_p.K7T|DTNA_ENST00000596745.1_Missense_Mutation_p.K7T|DTNA_ENST00000315456.6_Missense_Mutation_p.K7T|DTNA_ENST00000598774.1_Missense_Mutation_p.K7T|DTNA_ENST00000399097.3_5'UTR|DTNA_ENST00000348997.5_Missense_Mutation_p.K7T|DTNA_ENST00000444659.1_Missense_Mutation_p.K7T|DTNA_ENST00000269190.7_Missense_Mutation_p.K7T|DTNA_ENST00000399113.3_Missense_Mutation_p.K7T|DTNA_ENST00000399121.5_Missense_Mutation_p.K7T|DTNA_ENST00000554864.3_Missense_Mutation_p.K7T|RP11-138H11.1_ENST00000596954.1_RNA|DTNA_ENST00000597599.1_Missense_Mutation_p.K7T|DTNA_ENST00000598334.1_Missense_Mutation_p.K7T|DTNA_ENST00000595022.1_Missense_Mutation_p.K7T|DTNA_ENST00000269191.6_Missense_Mutation_p.K7T	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	7	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						GATAGTGGGAAAAGAGGAAAT	0.378000													19	18					0	0	0.069288	0	0
CCT7	10574	broad.mit.edu	37	2	73467575	73467575	+	Silent	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:73467575A>C	ENST00000539919.1	+	4	410	c.39A>C	c.(37-39)acA>acC	p.T13T	CCT7_ENST00000398422.2_Intron|CCT7_ENST00000258091.5_Silent_p.T57T|CCT7_ENST00000540468.1_Intron|CCT7_ENST00000473786.1_Intron|CCT7_ENST00000538797.1_5'UTR|CCT7_ENST00000537131.1_Intron	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	57					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						GCAAAGCAACAATTTCTAATG	0.413000													19	34					0	0	0.062417	0	0
ADD2	119	broad.mit.edu	37	2	70901940	70901940	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:70901940C>A	ENST00000264436.3	-	14	2055	c.1611G>T	c.(1609-1611)ctG>ctT	p.L537L	ADD2_ENST00000407644.2_Silent_p.L537L|ADD2_ENST00000355733.3_Silent_p.L537L	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	537					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CCTTGGACATCAGCTGGCTCT	0.537000													31	95					1.74807e-11	2.25665e-11	0.045705	1	0
OPRM1	4988	broad.mit.edu	37	6	154414512	154414512	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:154414512C>G	ENST00000229768.5	+	4	1322	c.1272C>G	c.(1270-1272)atC>atG	p.I424M	OPRM1_ENST00000337049.4_Intron|OPRM1_ENST00000522555.1_Intron|OPRM1_ENST00000414028.2_Intron|OPRM1_ENST00000360422.4_Intron|OPRM1_ENST00000524163.1_Intron|OPRM1_ENST00000522236.1_Intron|OPRM1_ENST00000434900.2_Intron|OPRM1_ENST00000452687.2_Intron|OPRM1_ENST00000435918.2_Intron|OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000518759.1_Intron|OPRM1_ENST00000330432.7_Intron|OPRM1_ENST00000419506.2_Intron	NM_001008505.1	NP_001008505.2	P35372	OPRM_HUMAN	opioid receptor, mu 1	0					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TCCCAGCTATCCTTCACTCGT	0.527000													59	44					0	0	0.048971	0	0
HIPK2	28996	broad.mit.edu	37	7	139288933	139288933	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:139288933G>A	ENST00000406875.3	-	10	2243	c.2149C>T	c.(2149-2151)Ccc>Tcc	p.P717S	HIPK2_ENST00000342645.6_Missense_Mutation_p.P717S|HIPK2_ENST00000428878.2_Missense_Mutation_p.P690S	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	717	Interaction with SKI and SMAD1.			PPA -> SPT (in Ref. 4; AAG35710).	apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					CATGCTGGGGGAAGCAGGATC	0.557000													56	112					0	0	0.048971	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092202	30092202	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:30092202C>A	ENST00000567636.1	+	0	577					NR_003558.1																						TCGAGAATGCCCAGCACGTGG	0.418000													5	18					1.23904e-05	1.41251e-05	0.014758	1	0
MIR4485	100616263	broad.mit.edu	37	MT	2776	2776	+	RNA	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:2776G>A	ENST00000387347.2	+	0	1106					NR_039705.1																						AACAAACCCACAGGTCCTAAA	0.473000													9	622					0	0	0.058154	0	0
OR8H2	390151	broad.mit.edu	37	11	55872880	55872880	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:55872880A>G	ENST00000313503.1	+	1	362	c.362A>G	c.(361-363)gAt>gGt	p.D121G		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					ATGGCCCATGATCGCTATGCA	0.458000										HNSCC(53;0.14)			4	328					0	0	0.009096	0	0
PTPRB	5787	broad.mit.edu	37	12	71029451	71029451	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:71029451C>A	ENST00000334414.6	-	2	495	c.451_splice	c.e2+1	p.A151_splice	PTPRB_ENST00000551525.1_Splice_Site_p.A150_splice|PTPRB_ENST00000550358.1_Splice_Site_p.A151_splice|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 2.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AATAGCTCACCTTTTTGTAAA	0.378000													4	77					0.00116845	0.00126213	0.021553	1	0
OSCAR	126014	broad.mit.edu	37	19	54604075	54604075	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:54604075C>A	ENST00000284648.6	-	2	206	c.9G>T	c.(7-9)ctG>ctT	p.L3L	OSCAR_ENST00000358375.4_Silent_p.L3L|OSCAR_ENST00000356532.3_Silent_p.L3L|OSCAR_ENST00000351806.4_Silent_p.L3L|OSCAR_ENST00000391760.1_Silent_p.L3L|OSCAR_ENST00000391761.1_Silent_p.L3L|OSCAR_ENST00000359649.4_Silent_p.L3L			Q8IYS5	OSCAR_HUMAN	osteoclast associated, immunoglobulin-like receptor	3						extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(1)|skin(1)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					GGATCAGCACCAGGGCCATGG	0.612000											OREG0003681	type=REGULATORY REGION|Gene=AK130199|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	1					0.00909568	0.0095062	0.009096	1	0
SPTBN1	6711	broad.mit.edu	37	2	54843381	54843381	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:54843381A>G	ENST00000333896.5	+	4	858	c.473A>G	c.(472-474)gAg>gGg	p.E158G	SPTBN1_ENST00000356805.4_Missense_Mutation_p.E171G	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	171	Actin-binding.|CH 1.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GACAACAAAGAGAAGAAATCT	0.438000													8	40					0	0	0.058154	0	0
STARD3	10948	broad.mit.edu	37	17	37815776	37815776	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:37815776G>T	ENST00000336308.5	+	9	983	c.765G>T	c.(763-765)caG>caT	p.Q255H	STARD3_ENST00000544210.2_Missense_Mutation_p.Q255H|STARD3_ENST00000394250.4_Missense_Mutation_p.Q237H|STARD3_ENST00000580611.1_Missense_Mutation_p.Q229H|STARD3_ENST00000578232.1_3'UTR	NM_001165937.1|NM_006804.3	NP_001159409.1|NP_006795.3	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain containing 3	255	START.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCTTGGCCCAGGAAGAGAACT	0.572000													10	13					4.68919e-08	5.6776e-08	0.069234	1	0
LEPROT	54741	broad.mit.edu	37	1	65895708	65895708	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:65895708G>T	ENST00000371065.4	+	3	394	c.256G>T	c.(256-258)Gtt>Ttt	p.V86F	LEPR_ENST00000406510.3_Intron|LEPROT_ENST00000484243.1_3'UTR|LEPR_ENST00000371059.3_Intron|LEPR_ENST00000349533.6_Intron|LEPR_ENST00000344610.8_Intron|LEPR_ENST00000371060.3_Intron	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	86						endosome membrane|Golgi membrane|integral to plasma membrane				kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGGATTTCCTGTTATTCTTGC	0.443000													50	181					4.88482e-21	7.19613e-21	0.048971	1	0
CLDN17	26285	broad.mit.edu	37	21	31538874	31538874	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:31538874G>T	ENST00000286808.3	-	1	97	c.62C>A	c.(61-63)aCt>aAt	p.T21N		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	21					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						TGTGGCAAGAGTCCCCACCAT	0.488000													21	102					7.92952e-12	1.02723e-11	0.091800	1	0
FSIP2	401024	broad.mit.edu	37	2	186672189	186672189	+	Silent	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:186672189A>C	ENST00000343098.5	+	17	18423	c.18423A>C	c.(18421-18423)gtA>gtC	p.V6141V	FSIP2_ENST00000424728.1_Silent_p.V6052V	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TGAAGTTAGTAAGTGCAGTTG	0.333000													57	282					0	0	0.048971	0	0
LHX8	431707	broad.mit.edu	37	1	75606693	75606693	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:75606693C>A	ENST00000294638.5	+	5	955	c.291C>A	c.(289-291)gtC>gtA	p.V97V	LHX8_ENST00000356261.3_Silent_p.V87V|LHX8_ENST00000559413.1_3'UTR	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	97	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						GCTGGCATGTCCGGTGTCTCT	0.393000													13	19					1.49906e-05	1.7063e-05	0.020292	1	0
CARF	79800	broad.mit.edu	37	2	203831748	203831748	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:203831748G>T	ENST00000320443.8	+	9	1923	c.880G>T	c.(880-882)Ggt>Tgt	p.G294C	CARF_ENST00000428585.1_Missense_Mutation_p.G218C|CARF_ENST00000402905.2_Missense_Mutation_p.G294C|CARF_ENST00000414439.1_Missense_Mutation_p.G192C|CARF_ENST00000456821.2_3'UTR|WDR12_ENST00000477723.1_Intron|CARF_ENST00000545253.1_Missense_Mutation_p.G206C|CARF_ENST00000545262.1_Missense_Mutation_p.G218C|CARF_ENST00000438828.2_Missense_Mutation_p.G294C					calcium responsive transcription factor																		AAGAAGAAAAGGTTTCCAGTT	0.403000													8	101					1.12685e-05	1.29057e-05	0.047766	1	0
OR56A3	390083	broad.mit.edu	37	11	5969312	5969312	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:5969312G>T	ENST00000329564.6	+	1	743	c.736G>T	c.(736-738)Ggc>Tgc	p.G246C		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGCACATGTGGCTCCCACTT	0.512000													36	133					1.04594e-18	1.50786e-18	0.086207	1	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	A	C	rs113451248		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:124857495A>C	ENST00000529051.1	+	8	1632	c.1373A>C	c.(1372-1374)cAc>cCc	p.H458P	CCDC15_ENST00000344762.5_Missense_Mutation_p.H458P			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418000													5	423					0	0	0.014758	0	0
SLC9A6	10479	broad.mit.edu	37	X	135098824	135098824	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:135098824C>A	ENST00000370695.4	+	10	1292	c.1257C>A	c.(1255-1257)ttC>ttA	p.F419L	SLC9A6_ENST00000370701.1_Missense_Mutation_p.F367L|SLC9A6_ENST00000370698.3_Missense_Mutation_p.F387L	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	387					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TTCTCAATTTCTTGGCAGAGA	0.348000													15	115					2.23348e-06	2.59406e-06	0.028581	1	0
MECP2	4204	broad.mit.edu	37	X	153297826	153297826	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:153297826G>T	ENST00000303391.6	-	3	458	c.209C>A	c.(208-210)tCc>tAc	p.S70Y	MECP2_ENST00000407218.1_Missense_Mutation_p.S70Y|MECP2_ENST00000453960.2_Missense_Mutation_p.S82Y	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	70					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCCGGGGCGGAGCCTGACCC	0.637000													50	48					5.39261e-20	7.88151e-20	0.048971	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	78					0	0	0.038147	0	0
HOXA3	3200	broad.mit.edu	37	7	27149875	27149875	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:27149875G>C	ENST00000396352.4	-	2	584	c.385C>G	c.(385-387)Cag>Gag	p.Q129E	HOXA3_ENST00000317201.2_Missense_Mutation_p.Q129E|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	129	Pro-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						CTGGCATTCTGAGGAGGGGAG	0.677000													18	35					0	0	0.043863	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33658334	33658334	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:33658334G>A	ENST00000504830.1	-	7	1480	c.1145C>T	c.(1144-1146)tCg>tTg	p.S382L	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.S382L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	382	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AGGGAGTCCCGAATCTTCATT	0.507000										HNSCC(64;0.19)			45	256					0	0	0.104719	0	0
PRDM10	56980	broad.mit.edu	37	11	129801063	129801063	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:129801063G>A	ENST00000358825.5	-	11	1609	c.1378C>T	c.(1378-1380)Cca>Tca	p.P460S	PRDM10_ENST00000528746.1_Missense_Mutation_p.P434S|PRDM10_ENST00000304538.6_Missense_Mutation_p.P374S|PRDM10_ENST00000360871.3_Missense_Mutation_p.P460S|PRDM10_ENST00000526082.1_Missense_Mutation_p.P374S|PRDM10_ENST00000423662.2_Missense_Mutation_p.P374S	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TGAGGGATTGGGATAGTGGTC	0.522000													27	155					0	0	0.099896	0	0
GNG11	2791	broad.mit.edu	37	7	93555527	93555527	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:93555527A>G	ENST00000248564.4	+	2	660	c.221A>G	c.(220-222)tAa>tGa	p.*74*		NM_004126.3	NP_004117.1	P61952	GBG11_HUMAN	guanine nucleotide binding protein (G protein), gamma 11	0					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway	heterotrimeric G-protein complex	GTPase activity|signal transducer activity			breast(1)|central_nervous_system(1)|kidney(1)|lung(2)|skin(1)	6	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			GTTATTTCATAAATAACTTGG	0.353000													47	66					0	0	0.048971	0	0
MYO3A	53904	broad.mit.edu	37	10	26436439	26436439	+	Silent	SNP	C	C	T	rs150600683		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:26436439C>T	ENST00000265944.5	+	23	2752	c.2586C>T	c.(2584-2586)tcC>tcT	p.S862S	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	862	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.S862S(1)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TGAGGTCATCCGACAACAGTG	0.403000													23	84					0	0	0.091800	0	0
PTX4	390667	broad.mit.edu	37	16	1536155	1536155	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:1536155C>T	ENST00000447419.2	-	3	1247	c.1222G>A	c.(1222-1224)Gac>Aac	p.D408N	PTX4_ENST00000293922.1_Missense_Mutation_p.D403N|PTX4_ENST00000440447.2_3'UTR			Q96A99	PTX4_HUMAN	pentraxin 4, long	408	Pentaxin.					extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						CCCACGCTGTCTTGTTCCTGG	0.667000													3	7					0	0	0.029380	0	0
SIRPD	128646	broad.mit.edu	37	20	1532360	1532360	+	Missense_Mutation	SNP	C	C	G	rs141059543		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:1532360C>G	ENST00000381623.3	-	2	1587	c.398G>C	c.(397-399)cGg>cCg	p.R133P	SIRPD_ENST00000381621.1_Missense_Mutation_p.R133P			Q9H106	SIRPD_HUMAN	signal-regulatory protein delta	133	Ig-like V-type.					extracellular region				breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)	15						CTGAGTGCCCCGACCTGATTG	0.443000													48	60					0	0	0.048971	0	0
ERN2	10595	broad.mit.edu	37	16	23718103	23718103	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:23718103G>A	ENST00000256797.4	-	6	771	c.603C>T	c.(601-603)tcC>tcT	p.S201S	ERN2_ENST00000457008.2_Silent_p.S153S	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	153					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGCGGGGGGTGGAGGGACCCT	0.607000													22	23					0	0	0.076483	0	0
MGME1	92667	broad.mit.edu	37	20	17950904	17950904	+	Silent	SNP	C	C	A	rs145801798		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:17950904C>A	ENST00000377710.5	+	2	690	c.402C>A	c.(400-402)acC>acA	p.T134T	MGME1_ENST00000377704.4_Silent_p.T134T|MGME1_ENST00000377709.1_Intron|MGME1_ENST00000467391.1_3'UTR	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		CAAGTGTGACCCGAGTCCTTC	0.428000													5	53					0.000602214	0.000661098	0.014758	1	0
PHKB	5257	broad.mit.edu	37	16	47533764	47533764	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:47533764A>G	ENST00000455779.1	+	4	428	c.243A>G	c.(241-243)ctA>ctG	p.L81L	PHKB_ENST00000567402.1_3'UTR|PHKB_ENST00000323584.5_Silent_p.L88L|PHKB_ENST00000299167.8_Silent_p.L88L|PHKB_ENST00000566044.1_Silent_p.L81L			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	88					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AGGACAGCCTATACTGCGCTG	0.507000													25	65					0	0	0.091800	0	0
SOGA2	23255	broad.mit.edu	37	18	8819248	8819248	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:8819248C>T	ENST00000359865.3	+	13	3289	c.3147C>T	c.(3145-3147)cgC>cgT	p.R1049R	SOGA2_ENST00000306285.7_Silent_p.R374R|SOGA2_ENST00000517570.1_Silent_p.R1008R|SOGA2_ENST00000518815.1_Silent_p.R374R|SOGA2_ENST00000400050.3_Silent_p.R1008R|SOGA2_ENST00000306329.11_Silent_p.R1368R	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1359																	TCAGGAACCGCCTCCCTGAGG	0.577000													17	20					0	0	0.038395	0	0
RLIM	51132	broad.mit.edu	37	X	73811612	73811612	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:73811612C>T	ENST00000332687.6	-	4	1756	c.1538G>A	c.(1537-1539)cGa>cAa	p.R513Q	RLIM_ENST00000349225.2_Missense_Mutation_p.R513Q	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	513					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GGCCCTATGTCGACCCTCTCG	0.473000													8	18					0	0	0.080935	0	0
FOXL1	2300	broad.mit.edu	37	16	86612523	86612523	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:86612523C>T	ENST00000320241.3	+	1	409	c.194C>T	c.(193-195)gCg>gTg	p.A65V		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	65					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						ATCCAGGACGCGCCCGAGCAG	0.662000													16	37					0	0	0.024245	0	0
TMEM9	252839	broad.mit.edu	37	1	201115898	201115898	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:201115898C>A	ENST00000367330.1	-	3	753	c.237G>T	c.(235-237)agG>agT	p.R79S	TMEM9_ENST00000367333.1_Missense_Mutation_p.R82S|TMEM9_ENST00000367332.1_Missense_Mutation_p.R82S|TMEM9_ENST00000367334.5_Missense_Mutation_p.R79S|TMEM9_ENST00000367329.1_Missense_Mutation_p.R79S			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	79					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				GCTCCTCGTACCTGCACTCGC	0.612000													28	141					3.1745e-13	4.19305e-13	0.037714	1	0
NLRP1	22861	broad.mit.edu	37	17	5425044	5425044	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:5425044C>G	ENST00000345221.3	-	13	4137	c.3583G>C	c.(3583-3585)Gag>Cag	p.E1195Q	NLRP1_ENST00000262467.5_Missense_Mutation_p.E1199Q|NLRP1_ENST00000577119.1_Missense_Mutation_p.E1165Q|NLRP1_ENST00000572272.1_Missense_Mutation_p.E1195Q|NLRP1_ENST00000269280.4_Missense_Mutation_p.E1195Q|NLRP1_ENST00000354411.3_Missense_Mutation_p.E1165Q	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1195					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GCTGGCTTCTCCAGGAGCATC	0.512000													27	21					0	0	0.108266	0	0
TENM1	10178	broad.mit.edu	37	X	123870869	123870869	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:123870869C>T	ENST00000422452.2	-	4	777	c.714G>A	c.(712-714)acG>acA	p.T238T	TENM1_ENST00000371130.3_Silent_p.T238T	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.T240T(2)									CTGAATCCTGCGTGCTGGTTG	0.542000													67	293					0	0	0.048971	0	0
MAP3K2	10746	broad.mit.edu	37	2	128087548	128087548	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:128087548A>C	ENST00000409947.1	-	7	697	c.415T>G	c.(415-417)Ttg>Gtg	p.L139V	MAP3K2_ENST00000344908.5_Missense_Mutation_p.L139V			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	139					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GTATTATCCAAATCTTCTAGT	0.348000													21	74					0	0	0.108266	0	0
DNAH9	1770	broad.mit.edu	37	17	11593663	11593663	+	Silent	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:11593663C>G	ENST00000262442.3	+	20	4592	c.4524C>G	c.(4522-4524)gtC>gtG	p.V1508V	DNAH9_ENST00000454412.2_Silent_p.V1508V	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1508	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGGACGCTGTCATCTCTATCT	0.493000													57	34					0	0	0.048971	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839073	128839073	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:128839073T>C	ENST00000310343.9	-	22	5992	c.5993A>G	c.(5992-5994)gAg>gGg	p.E1998G	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.E1649G|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.E1649G	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1998	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GGGGTCCCTCTCCACGTTCTG	0.532000													26	78					0	0	0.037714	0	0
ZEB1	6935	broad.mit.edu	37	10	31815884	31815884	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:31815884G>C	ENST00000446923.2	+	9	3410	c.3019G>C	c.(3019-3021)Gac>Cac	p.D1007H	ZEB1_ENST00000361642.5_Missense_Mutation_p.D1024H|ZEB1_ENST00000560721.2_Missense_Mutation_p.D1003H|ZEB1_ENST00000320985.10_Missense_Mutation_p.D1023H|ZEB1_ENST00000542815.3_Missense_Mutation_p.D956H	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1023	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GGGCGACTCGGACGAGAGAGA	0.522000													23	25					0	0	0.076483	0	0
TCERG1L	256536	broad.mit.edu	37	10	132891480	132891480	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:132891480A>T	ENST00000368642.4	-	12	1791	c.1706T>A	c.(1705-1707)cTt>cAt	p.L569H		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	569										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CTTAAGAATAAGTATGAATTG	0.443000													4	74					0	0	0.009096	0	0
FPR1	2357	broad.mit.edu	37	19	52250185	52250185	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:52250185G>T	ENST00000595042.1	-	3	204	c.63C>A	c.(61-63)ggC>ggA	p.G21G	FPR1_ENST00000304748.4_Silent_p.G21G	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	21					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGAAGAGATAGCCAGCAGATA	0.522000													23	58					5.35356e-11	6.8633e-11	0.076483	1	0
GAD2	2572	broad.mit.edu	37	10	26508009	26508009	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:26508009G>T	ENST00000376261.3	+	4	827	c.324G>T	c.(322-324)ttG>ttT	p.L108F	GAD2_ENST00000259271.3_Missense_Mutation_p.L108F|GAD2_ENST00000376248.1_5'UTR	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	108					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	GGCCCACTTTGGCGTTTCTGC	0.363000													7	30					0.0381472	0.039043	0.038147	1	0
RAB15	376267	broad.mit.edu	37	14	65417703	65417703	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:65417703G>C	ENST00000267512.5	-	4	493	c.413C>G	c.(412-414)tCc>tGc	p.S138C	RAB15_ENST00000436278.2_Missense_Mutation_p.S92C|RAB15_ENST00000426039.3_Intron|RAB15_ENST00000533601.2_Intron|CHURC1-FNTB_ENST00000542227.1_Intron|CHURC1-FNTB_ENST00000447296.2_Intron	NM_198686.2	NP_941959.1	P59190	RAB15_HUMAN	RAB15, member RAS oncogene family	207					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	8				all cancers(60;0.00136)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.0102)		AAGCTTCCTGGAAGCATTTGC	0.592000													8	39					0	0	0.047766	0	0
PHF6	84295	broad.mit.edu	37	X	133547965	133547965	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:133547965C>G	ENST00000332070.3	+	7	900	c.698C>G	c.(697-699)gCc>gGc	p.A233G	PHF6_ENST00000370803.3_Missense_Mutation_p.A233G|PHF6_ENST00000370800.4_Missense_Mutation_p.A234G|PHF6_ENST00000370799.1_Missense_Mutation_p.A234G|PHF6_ENST00000394292.1_Missense_Mutation_p.A234G|PHF6_ENST00000416404.2_Missense_Mutation_p.A199G	NM_032458.2	NP_115834.1	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					ATATTTAATGCCAAGAAGGCA	0.418000			"""F, N, Splice, Mis"""		ETP ALL								96	117					0	0	0.048971	0	0
CCL28	56477	broad.mit.edu	37	5	43388579	43388579	+	Splice_Site	SNP	C	C	A	rs78470036		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:43388579C>A	ENST00000361115.4	-	2	139		c.e2-1		CCL28_ENST00000513525.1_Splice_Site|CCL28_ENST00000537013.1_Splice_Site	NM_148672.2	NP_683513.1	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28						chemotaxis|immune response	extracellular space	chemokine activity			kidney(3)|lung(3)|ovary(1)	7						GGAAGTATGGCTAAAAGAAGA	0.388000													16	14					3.52763e-06	4.07796e-06	0.033300	1	0
CX3CL1	6376	broad.mit.edu	37	16	57416912	57416912	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:57416912G>C	ENST00000565912.1	+	2	3754	c.1048G>C	c.(1048-1050)Ggt>Cgt	p.G350R	CX3CL1_ENST00000006053.6_Missense_Mutation_p.G388R|CX3CL1_ENST00000563383.1_Missense_Mutation_p.G394R			P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	388					cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CCGGAGCTGTGGTAGTAATTC	0.582000													20	67					0	0	0.055883	0	0
PKP1	5317	broad.mit.edu	37	1	201263122	201263122	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:201263122G>T	ENST00000263946.3	+	2	506	c.255G>T	c.(253-255)agG>agT	p.R85S	PKP1_ENST00000367324.3_Missense_Mutation_p.R85S|PKP1_ENST00000352845.3_Missense_Mutation_p.R85S	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	85					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CCACCAGCAGGAGCAGCTACT	0.507000													5	13					3.59834e-05	4.0584e-05	0.021553	1	0
GPR112	139378	broad.mit.edu	37	X	135427841	135427841	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:135427841G>T	ENST00000394143.1	+	6	2267	c.1976G>T	c.(1975-1977)aGg>aTg	p.R659M	GPR112_ENST00000412101.1_Missense_Mutation_p.R454M|GPR112_ENST00000370652.1_Missense_Mutation_p.R659M|GPR112_ENST00000287534.4_Missense_Mutation_p.R596M|GPR112_ENST00000394141.1_Missense_Mutation_p.R454M	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	659					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGGACTTCTAGGCCAGACCAG	0.458000													188	635					5.05562e-99	8.57257e-99	0.048971	1	0
USH2A	7399	broad.mit.edu	37	1	216246298	216246298	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:216246298T>A	ENST00000366943.2	-	29	6176	c.5790A>T	c.(5788-5790)cgA>cgT	p.R1930R	RP11-22M7.2_ENST00000430890.1_RNA|USH2A_ENST00000307340.3_Silent_p.R1930R|RP11-22M7.2_ENST00000445619.1_RNA|RP11-22M7.2_ENST00000446411.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1930	Fibronectin type-III 5.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGCTATCACTCGATACAGGT	0.403000										HNSCC(13;0.011)			87	182					0	0	0.048971	0	0
TRIM58	25893	broad.mit.edu	37	1	248039252	248039252	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:248039252G>A	ENST00000366481.3	+	6	970	c.922G>A	c.(922-924)Gcc>Acc	p.A308T	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	308	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCTCTTGACCGCCGACCTGCG	0.572000													36	93					0	0	0.074837	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361102	105361102	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:105361102T>A	ENST00000297581.2	+	2	371	c.322T>A	c.(322-324)Ttg>Atg	p.L108M	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Missense_Mutation_p.L108M	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	108					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											GATCGTCATCTTGGGACACGT	0.428000													18	93					0	0	0.033300	0	0
BTN3A3	10384	broad.mit.edu	37	6	26448982	26448982	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:26448982C>A	ENST00000244519.2	+	8	1207	c.964_splice	c.e8+1	p.R322_splice	BTN3A3_ENST00000339789.4_Splice_Site_p.R280_splice|BTN3A3_ENST00000361232.3_Splice_Site_p.R273_splice	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	322	B30.2/SPRY.					integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						GTACATGGCTCGTGAGTGACT	0.443000													28	87					1.2476e-16	1.74758e-16	0.030593	1	0
WWP1	11059	broad.mit.edu	37	8	87440021	87440021	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:87440021A>C	ENST00000517970.1	+	11	1614	c.1307A>C	c.(1306-1308)cAg>cCg	p.Q436P	WWP1_ENST00000349423.2_Missense_Mutation_p.Q218P|WWP1_ENST00000341922.2_Missense_Mutation_p.Q306P|WWP1_ENST00000265428.4_Missense_Mutation_p.Q436P	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	436					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						GCTATGCAACAGTTTAACCAA	0.418000													5	158					0	0	0.021553	0	0
KCNK9	51305	broad.mit.edu	37	8	140630832	140630832	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:140630832G>A	ENST00000520439.1	-	2	857	c.794C>T	c.(793-795)gCc>gTc	p.A265V	KCNK9_ENST00000303015.1_Missense_Mutation_p.A265V			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	265						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GCGGTTTCCGGCGAGGGATGC	0.632000													17	61					0	0	0.038395	0	0
PAMR1	25891	broad.mit.edu	37	11	35492293	35492293	+	Missense_Mutation	SNP	G	G	A	rs144144764	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:35492293G>A	ENST00000378880.2	-	5	1013	c.568C>T	c.(568-570)Cgc>Tgc	p.R190C	PAMR1_ENST00000378878.3_Intron|PAMR1_ENST00000534803.1_5'UTR|PAMR1_ENST00000532848.1_Missense_Mutation_p.R150C|PAMR1_ENST00000278360.3_Missense_Mutation_p.R190C	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	190	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity	p.R190S(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						TGGCCATCGCGGTTGTCTCCA	0.547000													5	35					0	0	0.014758	0	0
DLG5	9231	broad.mit.edu	37	10	79580869	79580869	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:79580869G>T	ENST00000372391.2	-	15	3378	c.3373C>A	c.(3373-3375)Cca>Aca	p.P1125T	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1125					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ATCACTACTGGAGCAAGCTTC	0.597000													9	23					5.4927e-09	6.76095e-09	0.047766	1	0
USH2A	7399	broad.mit.edu	37	1	216061977	216061977	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:216061977G>T	ENST00000366943.2	-	41	8400	c.8014C>A	c.(8014-8016)Ctg>Atg	p.L2672M	USH2A_ENST00000307340.3_Missense_Mutation_p.L2672M|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2672	Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGAGTCACCAGGGTAGTAACT	0.448000										HNSCC(13;0.011)			4	105					0.00116845	0.00126213	0.021553	1	0
LTB	4050	broad.mit.edu	37	6	31548850	31548850	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:31548850C>T	ENST00000429299.2	-	4	378	c.371G>A	c.(370-372)gGg>gAg	p.G124E	LTB_ENST00000483972.1_5'UTR|LTB_ENST00000446745.2_3'UTR	NM_002341.1	NP_002332.1	Q06643	TNFC_HUMAN	lymphotoxin beta (TNF superfamily, member 3)	124					cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9					Infliximab(DB00065)|Simvastatin(DB00641)	GAGCGCCAGCCCCTCGGCGTC	0.721000													3	10					0	0	0.009096	0	0
SVEP1	79987	broad.mit.edu	37	9	113168917	113168917	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:113168917C>G	ENST00000401783.2	-	38	9299	c.8963G>C	c.(8962-8964)aGg>aCg	p.R2988T	SVEP1_ENST00000297826.5_Missense_Mutation_p.R914T|SVEP1_ENST00000374469.1_Missense_Mutation_p.R2965T	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2988	Sushi 26.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GGAGAGGCACCTTCTTGATGA	0.468000													13	28					0	0	0.020292	0	0
FAM47A	158724	broad.mit.edu	37	X	34148219	34148219	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:34148219T>C	ENST00000346193.3	-	1	2228	c.2177A>G	c.(2176-2178)gAa>gGa	p.E726G		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	726										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						AACGTCAGGTTCATCAGGCTT	0.418000													21	72					0	0	0.062417	0	0
TCHHL1	126637	broad.mit.edu	37	1	152057836	152057836	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152057836G>T	ENST00000368806.1	-	3	2386	c.2322C>A	c.(2320-2322)ccC>ccA	p.P774P		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	774							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GACTTGACCAGGGGACTGAAG	0.498000													6	380					0.0215528	0.0222742	0.021553	1	0
XIRP2	129446	broad.mit.edu	37	2	168099943	168099943	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:168099943A>C	ENST00000409195.1	+	9	2130	c.2041A>C	c.(2041-2043)Agt>Cgt	p.S681R	XIRP2_ENST00000409273.1_Missense_Mutation_p.S459R|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.S681R|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	506					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GGTAACTATCAGTAAGGACAT	0.428000													29	108					0	0	0.034045	0	0
RFTN2	130132	broad.mit.edu	37	2	198498522	198498522	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:198498522T>A	ENST00000295049.3	-	4	1174	c.638A>T	c.(637-639)gAa>gTa	p.E213V		NM_144629.2	NP_653230.2	Q52LD8	RFTN2_HUMAN	raftlin family member 2	213						plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(13)|urinary_tract(3)	30						ATGAAGTTCTTCCTCAATTCC	0.408000													18	102					0	0	0.043863	0	0
TP53	7157	broad.mit.edu	37	17	7579358	7579358	+	Missense_Mutation	SNP	C	C	A	rs11540654		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:7579358C>A	ENST00000420246.2	-	4	461	c.329G>T	c.(328-330)cGt>cTt	p.R110L	TP53_ENST00000445888.2_Missense_Mutation_p.R110L|TP53_ENST00000455263.2_Missense_Mutation_p.R110L|TP53_ENST00000413465.2_Missense_Mutation_p.R110L|TP53_ENST00000269305.4_Missense_Mutation_p.R110L|TP53_ENST00000359597.4_Missense_Mutation_p.R110L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	110	Interaction with HIPK1 (By similarity).|Interaction with WWOX.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation; dbSNP:rs11540654).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(36)|p.R110P(9)|p.0?(8)|p.G59fs*23(3)|p.R110fs*13(2)|p.F109_R110delFR(2)|p.R110H(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGCCCAGACGGAAACCGTA	0.612000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			79	58					4.9328e-52	8.14076e-52	0.048971	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14852041	14852041	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:14852041C>A	ENST00000358984.4	+	36	3921	c.3741C>A	c.(3739-3741)ctC>ctA	p.L1247L		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1332										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						AAATTAATCTCAATTATGCAG	0.353000													9	6					7.48243e-07	8.82879e-07	0.058154	1	0
ATG2B	55102	broad.mit.edu	37	14	96794827	96794827	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:96794827G>A	ENST00000359933.4	-	14	2913	c.2020C>T	c.(2020-2022)Caa>Taa	p.Q674*		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	674										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AATTTAATTTGCAATTCTGCC	0.333000													11	46					0	0	0.093190	0	0
KIF11	3832	broad.mit.edu	37	10	94373192	94373192	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:94373192G>T	ENST00000260731.3	+	8	938	c.848G>T	c.(847-849)cGg>cTg	p.R283L		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	283	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAGAGAGCTCGGGAAGCTGGA	0.373000													6	45					0.000274275	0.000301988	0.047766	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177681	89177681	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:89177681C>A	ENST00000561129.2	+	1	727	c.597C>A	c.(595-597)tcC>tcA	p.S199S	TGIF2LX_ENST00000283891.5_Silent_p.S199S			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	199						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						CTGTCACATCCCCGTCTTCTC	0.562000													13	33					0.00244969	0.00260808	0.020292	1	0
ZNF512	84450	broad.mit.edu	37	2	27839183	27839183	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:27839183T>G	ENST00000355467.4	+	12	1371	c.1288T>G	c.(1288-1290)Tgt>Ggt	p.C430G	ZNF512_ENST00000556601.1_Missense_Mutation_p.C299G|ZNF512_ENST00000379717.1_Missense_Mutation_p.C429G|ZNF512_ENST00000416005.2_Missense_Mutation_p.C401G|ZNF512_ENST00000413371.2_Missense_Mutation_p.C353G|RP11-158I13.2_ENST00000505973.1_RNA			Q96ME7	ZN512_HUMAN	zinc finger protein 512	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					CCTGGGCTCTTGTACATTGGT	0.408000													3	90					0	0	0.004672	0	0
FAM134B	54463	broad.mit.edu	37	5	16475022	16475022	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:16475022G>T	ENST00000306320.9	-	9	1408	c.1322C>A	c.(1321-1323)cCc>cAc	p.P441H	FAM134B_ENST00000399793.2_Missense_Mutation_p.P300H	NM_001034850.2	NP_001030022.1	Q9H6L5	F134B_HUMAN	family with sequence similarity 134, member B	441					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				breast(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(1)	16						TTCTGGGATGGGGGCAGCCTG	0.493000													36	69					9.04072e-19	1.31356e-18	0.059317	1	0
HIST1H4D	8360	broad.mit.edu	37	6	26189055	26189055	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:26189055C>T	ENST00000340756.2	-	1	249	c.250G>A	c.(250-252)Gcc>Acc	p.A84T		NM_003539.3	NP_003530.1	P62805	H4_HUMAN	histone cluster 1, H4d	84					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)	8		all_hematologic(11;0.196)				ACGTCCATGGCTGTGACTGTC	0.537000													20	76					0	0	0.083992	0	0
SMIM14	201895	broad.mit.edu	37	4	39606740	39606740	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:39606740C>T	ENST00000295958.4	-	2	412	c.26G>A	c.(25-27)tGt>tAt	p.C9Y	SMIM14_ENST00000510628.1_Intron|SMIM14_ENST00000511809.1_Missense_Mutation_p.C9Y	NM_174921.1	NP_777581.1			small integral membrane protein 14																		AACACATTCACAGGGATCAAA	0.388000													8	31					0	0	0.038147	0	0
CXorf27	25763	broad.mit.edu	37	X	37850383	37850383	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:37850383C>G	ENST00000341016.3	+	1	314	c.291C>G	c.(289-291)agC>agG	p.S97R	TM4SF2_ENST00000465127.1_Intron	NM_012274.1	NP_036406.1	O75409	HYPM_HUMAN	chromosome X open reading frame 27	97							DNA binding	p.S97S(1)		central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)	8						AGCCCCACAGCGCTGAGAGTG	0.527000													10	12					0	0	0.058154	0	0
GRIA2	2891	broad.mit.edu	37	4	158283987	158283987	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:158283987G>T	ENST00000296526.7	+	15	2768	c.2443G>T	c.(2443-2445)Gga>Tga	p.G815*	GRIA2_ENST00000449365.1_Nonsense_Mutation_p.G768*|GRIA2_ENST00000393815.2_Nonsense_Mutation_p.G768*|GRIA2_ENST00000507898.1_Nonsense_Mutation_p.G768*|GRIA2_ENST00000264426.9_Nonsense_Mutation_p.G815*	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	815					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CAACGTTGCTGGAGTATTCTA	0.463000													40	63					2.37825e-27	3.65619e-27	0.039052	1	0
GLE1	2733	broad.mit.edu	37	9	131271368	131271368	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:131271368G>T	ENST00000309971.4	+	2	419	c.313G>T	c.(313-315)Gga>Tga	p.G105*	GLE1_ENST00000539582.1_5'UTR|GLE1_ENST00000372770.4_Nonsense_Mutation_p.G105*	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	105					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						AACACCAAATGGAACCAAGGT	0.468000													14	16					1.62849e-17	2.30729e-17	0.028581	1	0
FOXR1	283150	broad.mit.edu	37	11	118849735	118849735	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:118849735G>T	ENST00000317011.3	+	3	430	c.205G>T	c.(205-207)Gag>Tag	p.E69*		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	69					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TGGAAAGCTGGAGGTCTCAGG	0.562000													43	81					4.10826e-27	6.27675e-27	0.048971	1	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000402731.1_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	79					0	0	0.038147	0	0
OR8K5	219453	broad.mit.edu	37	11	55926935	55926935	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:55926935G>C	ENST00000313447.1	-	1	858	c.859C>G	c.(859-861)Cct>Gct	p.P287A		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P287T(1)		large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				TAAATCAAAGGGTTAAGCATG	0.343000													11	83					0	0	0.069234	0	0
LYST	1130	broad.mit.edu	37	1	235904858	235904858	+	Missense_Mutation	SNP	C	C	G	rs148018560		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:235904858C>G	ENST00000389794.3	-	31	8396	c.8222G>C	c.(8221-8223)cGa>cCa	p.R2741P	LYST_ENST00000389793.2_Missense_Mutation_p.R2741P			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2741					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAGCTGCATTCGGAAGGTCTC	0.413000													7	41					0	0	0.047766	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102474633	102474633	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:102474633A>G	ENST00000360184.4	+	29	6100	c.5936A>G	c.(5935-5937)cAg>cGg	p.Q1979R		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1979	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CAGTGCATACAGGAAGCACTG	0.527000													6	19					0	0	0.029380	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092203	30092203	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:30092203C>A	ENST00000567636.1	+	0	578					NR_003558.1																						CGAGAATGCCCAGCACGTGGA	0.423000													5	18					1.23904e-05	1.41251e-05	0.014758	1	0
MMP16	4325	broad.mit.edu	37	8	89179914	89179914	+	Silent	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:89179914T>C	ENST00000286614.6	-	4	974	c.693A>G	c.(691-693)ggA>ggG	p.G231G	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	231					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GATTAGGATTTCCTAGTGTCC	0.368000													5	64					0	0	0.021553	0	0
EPHA6	285220	broad.mit.edu	37	3	97251372	97251372	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:97251372G>A	ENST00000389672.5	+	11	2409	c.2371G>A	c.(2371-2373)Ggg>Agg	p.G791R	EPHA6_ENST00000442602.2_Missense_Mutation_p.G157R|EPHA6_ENST00000514100.1_Missense_Mutation_p.G183R|EPHA6_ENST00000502694.1_Missense_Mutation_p.G183R	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	696	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TCGCCTAGAAGGGGTTGTCAC	0.368000													28	39					0	0	0.034045	0	0
CYGB	114757	broad.mit.edu	37	17	74533541	74533541	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:74533541C>T	ENST00000293230.5	-	1	446	c.84G>A	c.(82-84)caG>caA	p.Q28Q	PRCD_ENST00000592432.1_Intron|CYGB_ENST00000589342.1_Silent_p.Q28Q|CYGB_ENST00000589145.1_Intron	NM_134268.4	NP_599030.1	Q8WWM9	CYGB_HUMAN	cytoglobin	28	Globin.				response to oxidative stress	cytoplasm	heme binding|oxygen binding|oxygen transporter activity|peroxidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)	7						CCCACATAGCCTGCACCGCCT	0.692000													3	7					0	0	0.004672	0	0
EPHA7	2045	broad.mit.edu	37	6	93956666	93956666	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:93956666G>A	ENST00000369303.4	-	15	2754	c.2570C>T	c.(2569-2571)gCa>gTa	p.A857V		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	857	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTCCATGGGTGCTGGTAAACG	0.373000													16	39					0	0	0.028581	0	0
F8	2157	broad.mit.edu	37	X	154088834	154088834	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:154088834T>C	ENST00000360256.4	-	25	6973	c.6773A>G	c.(6772-6774)aAa>aGa	p.K2258R	F8_ENST00000330287.6_Missense_Mutation_p.K123R	NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2258	F5/8 type C 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCCTGTGACTTTCATTGTCTT	0.463000													12	311					0	0	0.093190	0	0
DOCK2	1794	broad.mit.edu	37	5	169477278	169477278	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:169477278C>A	ENST00000256935.8	+	41	4170	c.4090C>A	c.(4090-4092)Cgc>Agc	p.R1364S	DOCK2_ENST00000540750.1_Missense_Mutation_p.R425S|DOCK2_ENST00000520908.1_Missense_Mutation_p.R856S|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1364	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTCATCTACCGCGGGAAGGA	0.502000													77	123					1.00246e-47	1.64706e-47	0.048971	1	0
GALNT13	114805	broad.mit.edu	37	2	155115588	155115588	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:155115588G>T	ENST00000392825.3	+	8	1479	c.912G>T	c.(910-912)gaG>gaT	p.E304D	GALNT13_ENST00000409237.1_Missense_Mutation_p.E304D|GALNT13_ENST00000487047.1_3'UTR	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	304	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						ACTTTGAAGAGATAGGAACTT	0.333000													52	94					1.32667e-27	2.04379e-27	0.048971	1	0
SLITRK1	114798	broad.mit.edu	37	13	84454262	84454262	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:84454262G>C	ENST00000377084.2	-	1	2266	c.1381C>G	c.(1381-1383)Ctc>Gtc	p.L461V		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	461						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GGGAGGATGAGCTGGATAGCG	0.542000													24	16					0	0	0.076483	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43626714	43626714	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:43626714T>C	ENST00000332857.6	-	4	2001	c.1973A>G	c.(1972-1974)cAg>cGg	p.Q658R		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CCTCTCTAGCTGGAACTTCAC	0.562000													30	89					0	0	0.048971	0	0
CSF3R	1441	broad.mit.edu	37	1	36932411	36932411	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:36932411G>T	ENST00000338937.5	-	14	1963	c.1964C>A	c.(1963-1965)cCg>cAg	p.P655Q	CSF3R_ENST00000373106.1_Silent_p.P686P|CSF3R_ENST00000440588.2_Silent_p.P713P|CSF3R_ENST00000373103.1_Silent_p.P713P|CSF3R_ENST00000361632.4_Silent_p.P686P|CSF3R_ENST00000418048.2_Silent_p.P686P|CSF3R_ENST00000373104.1_Silent_p.P686P|CSF3R_ENST00000331941.5_Silent_p.P686P|CSF3R_ENST00000487540.2_5'UTR			Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	0					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGCCAAGGCCGGGCAGCTGGA	0.617000													24	58					0.000720815	0.000787794	0.099896	1	0
CCDC155	147872	broad.mit.edu	37	19	49901271	49901271	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:49901271A>G	ENST00000447857.3	+	7	705	c.500A>G	c.(499-501)gAg>gGg	p.E167G		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	167						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						AGCAGCCTGGAGGACCTGGAG	0.617000													4	27					0	0	0.021553	0	0
CC2D1B	200014	broad.mit.edu	37	1	52827271	52827271	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:52827271G>C	ENST00000371586.2	-	4	370	c.232C>G	c.(232-234)Cac>Gac	p.H78D	CC2D1B_ENST00000438831.1_5'UTR|CC2D1B_ENST00000284376.3_Missense_Mutation_p.H78D	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	78										breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						TTCTCGATGTGGGCCATGGGC	0.577000													3	20					0	0	0.014758	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475894	140475894	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140475894C>A	ENST00000194155.4	+	1	1668	c.1520C>A	c.(1519-1521)tCc>tAc	p.S507Y		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		507	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCTGGTCTCCATCAACGCG	0.697000													27	36					3.62531e-18	5.19604e-18	0.069456	1	0
OR4C11	219429	broad.mit.edu	37	11	55370991	55370991	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:55370991G>T	ENST00000302231.4	-	1	883	c.859C>A	c.(859-861)Ctg>Atg	p.L287M		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						GCATTCCTCAGTGTGTAGATG	0.403000													31	41					3.78316e-11	4.86687e-11	0.086207	1	0
THSD7B	80731	broad.mit.edu	37	2	138169324	138169324	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:138169324C>G	ENST00000409968.1	+	14	3019	c.2841C>G	c.(2839-2841)caC>caG	p.H947Q	THSD7B_ENST00000272643.3_Missense_Mutation_p.H947Q|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.H916Q					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGGAGCCTCACCGAGGACTGC	0.483000													41	219					0	0	0.104719	0	0
GPR141	353345	broad.mit.edu	37	7	37780805	37780805	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:37780805G>T	ENST00000447769.1	+	4	1099	c.810G>T	c.(808-810)ttG>ttT	p.L270F	EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.L270F|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	270						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AAATCTTCTTGAGTGTAACAG	0.378000													82	117					6.44082e-31	1.0133e-30	0.048971	1	0
BEST3	144453	broad.mit.edu	37	12	70070771	70070771	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:70070771G>A	ENST00000330891.5	-	7	1018	c.792C>T	c.(790-792)taC>taT	p.Y264Y	BEST3_ENST00000331471.4_Silent_p.Y264Y|BEST3_ENST00000553096.1_Silent_p.Y158Y|BEST3_ENST00000488961.1_Intron|BEST3_ENST00000476098.1_Intron	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	264						chloride channel complex|plasma membrane	chloride channel activity	p.Y264Y(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CATGCCCTGCGTAGCCTTTGG	0.502000													30	177					0	0	0.034045	0	0
TSG101	7251	broad.mit.edu	37	11	18505561	18505561	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:18505561C>T	ENST00000536719.1	-	8	833	c.699G>A	c.(697-699)gcG>gcA	p.A233A	TSG101_ENST00000357193.3_Silent_p.A128A|TSG101_ENST00000251968.3_Silent_p.A233A			Q99816	TS101_HUMAN	tumor susceptibility 101	233					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding	p.A233A(1)		kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						TGTCACTGACCGCAGAGATGA	0.517000													56	157					0	0	0.048971	0	0
PPARD	5467	broad.mit.edu	37	6	35378976	35378976	+	Missense_Mutation	SNP	C	C	A	rs147861745		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:35378976C>A	ENST00000311565.4	+	4	461	c.112C>A	c.(112-114)Cct>Act	p.P38T	PPARD_ENST00000418635.2_Missense_Mutation_p.P38T|PPARD_ENST00000337400.2_Missense_Mutation_p.P38T|PPARD_ENST00000444397.1_Missense_Mutation_p.P38T|PPARD_ENST00000360694.3_Missense_Mutation_p.P38T|PPARD_ENST00000448077.2_Intron|PPARD_ENST00000540939.1_Intron	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	38					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	GCATGCACTTCCTTCCAGCAG	0.627000													14	36					7.93312e-07	9.3457e-07	0.020292	1	0
XKR7	343702	broad.mit.edu	37	20	30584859	30584859	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:30584859G>T	ENST00000217299.3	+	3	1513	c.1339G>T	c.(1339-1341)Ggt>Tgt	p.G447C		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	447						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCCCATGCTGGGTCCCCAGGC	0.612000													7	32					0.0293803	0.0301953	0.029380	1	0
HTR5A	3361	broad.mit.edu	37	7	154876139	154876139	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:154876139C>G	ENST00000287907.2	+	2	1592	c.1016C>G	c.(1015-1017)aCg>aGg	p.T339R	HTR5A_ENST00000486819.1_3'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	339						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CTGATCTATACGGCTTTCAAC	0.473000													19	110					0	0	0.055883	0	0
ENOSF1	55556	broad.mit.edu	37	18	691265	691265	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:691265C>A	ENST00000383578.3	-	5	393	c.189G>T	c.(187-189)atG>atT	p.M63I	ENOSF1_ENST00000580982.1_Intron|ENOSF1_ENST00000251101.7_Missense_Mutation_p.M145I|ENOSF1_ENST00000539164.1_3'UTR|ENOSF1_ENST00000340116.7_Missense_Mutation_p.M166I	NM_001126123.3	NP_001119595.1	Q7L5Y1	ENOF1_HUMAN	enolase superfamily member 1	145					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	10						AGGATACCAGCATCCTGGGAT	0.428000													14	28					1.05317e-09	1.32947e-09	0.020292	1	0
OR4S2	219431	broad.mit.edu	37	11	55419009	55419009	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:55419009T>A	ENST00000312422.2	+	1	630	c.630T>A	c.(628-630)gtT>gtA	p.V210V		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GGAGTTTTGTTATCTTGCTAA	0.493000													116	219					0	0	0.048971	0	0
SLC33A1	9197	broad.mit.edu	37	3	155571368	155571368	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:155571368C>T	ENST00000392845.2	-	1	799	c.419G>A	c.(418-420)cGc>cAc	p.R140H	SLC33A1_ENST00000359479.3_Missense_Mutation_p.R140H	NM_004733.3	NP_004724.1	O00400	ACATN_HUMAN	solute carrier family 33 (acetyl-CoA transporter), member 1	140					cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	22			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCAAGATTTGCGACGACCGAA	0.463000													3	17					0	0	0.004672	0	0
ZNF248	57209	broad.mit.edu	37	10	38121256	38121256	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:38121256G>C	ENST00000395867.3	-	6	1577	c.1027C>G	c.(1027-1029)Caa>Gaa	p.Q343E	ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Missense_Mutation_p.Q343E	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						TGTACTATTTGATGTTTTAAG	0.403000													42	118					0	0	0.045515	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192419	132192419	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:132192419C>A	ENST00000359827.3	-	2	1996	c.1034G>T	c.(1033-1035)cGg>cTg	p.R345L	PLXNA4_ENST00000378539.5_Missense_Mutation_p.R345L|PLXNA4_ENST00000321063.4_Missense_Mutation_p.R345L|PLXNA4_ENST00000423507.2_Missense_Mutation_p.R345L			Q9HCM2	PLXA4_HUMAN	plexin A4	345	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TTTCATTTTCCGCTTCTGGCC	0.562000													52	67					2.43277e-16	3.3885e-16	0.048971	1	0
DDX25	29118	broad.mit.edu	37	11	125780288	125780288	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:125780288G>T	ENST00000263576.6	+	7	692	c.537G>T	c.(535-537)ttG>ttT	p.L179F	DDX25_ENST00000525943.1_3'UTR|RP11-680F20.9_ENST00000533033.2_RNA	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	179	Helicase ATP-binding.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		CTTATGAATTGGCTCTGCAAA	0.453000													42	110					3.39706e-21	5.01438e-21	0.048971	1	0
MAPK8IP1	9479	broad.mit.edu	37	11	45926331	45926331	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:45926331C>G	ENST00000395629.2	+	9	2139	c.1809C>G	c.(1807-1809)atC>atG	p.I603M	MAPK8IP1_ENST00000241014.2_Missense_Mutation_p.I613M			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	613	PID.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		TCCTGGAGATCAGCGTGCGGG	0.607000													6	34					0	0	0.029380	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110510782	110510782	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:110510782G>A	ENST00000378402.5	+	66	10795	c.10691G>A	c.(10690-10692)cGg>cAg	p.R3564Q		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3564					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCTGCTCATCGGAGTCCTAGA	0.343000										HNSCC(38;0.096)			21	132					0	0	0.055883	0	0
STT3B	201595	broad.mit.edu	37	3	31641905	31641905	+	Silent	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:31641905A>T	ENST00000295770.2	+	5	1040	c.831A>T	c.(829-831)gtA>gtT	p.V277V	STT3B_ENST00000453168.1_3'UTR	NM_178862.1	NP_849193.1	Q8TCJ2	STT3B_HUMAN	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	277					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			autonomic_ganglia(1)|biliary_tract(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	19						CACTGCATGTATTTGTGTTGT	0.308000													8	29					0	0	0.069234	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11295	11295	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:11295T>C	ENST00000361381.2	+	1	536	c.536T>C	c.(535-537)cTc>cCc	p.179_179insP						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CATTCTACTACTCACTCTCAC	0.418000													431	122					0	0	0.048971	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203277	140203277	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140203277C>A	ENST00000529859.1	+	1	1917	c.1917C>A	c.(1915-1917)acC>acA	p.T639T	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000378126.3_Silent_p.T639T|PCDHA5_ENST00000529619.1_Silent_p.T639T|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGATGAGACCGAAGCACCGC	0.642000													7	37					2.0095e-06	2.34125e-06	0.029380	1	0
TBX22	50945	broad.mit.edu	37	X	79279574	79279574	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:79279574C>T	ENST00000442340.1	+	4	499	c.9C>T	c.(7-9)ccC>ccT	p.P3P	TBX22_ENST00000373294.5_Silent_p.P123P|TBX22_ENST00000373291.1_Silent_p.P3P|TBX22_ENST00000373296.3_Silent_p.P123P	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	123					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						GGATGTTCCCCTCTGTTCGGG	0.493000													15	88					0	0	0.049695	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33628275	33628275	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:33628275T>A	ENST00000321505.4	+	13	4257	c.4077T>A	c.(4075-4077)tcT>tcA	p.S1359S	KIAA1549L_ENST00000389726.3_Silent_p.S1365S					KIAA1549-like																		CTTCTGGGTCTGTGCAGCTCA	0.582000													46	23					0	0	0.048971	0	0
RFPL4A	342931	broad.mit.edu	37	19	56274270	56274270	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:56274270C>A	ENST00000434937.2	+	3	764	c.593C>A	c.(592-594)gCt>gAt	p.A198D		NM_001145014.1	NP_001138486.1	A6NLU0	RFPLA_HUMAN	ret finger protein-like 4A	198	B30.2/SPRY.						zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|stomach(1)	2						AAGGTCTTTGCTGCCAGCACT	0.512000													4	17					4.68919e-08	5.6776e-08	0.069234	1	0
FHL1	2273	broad.mit.edu	37	X	135290730	135290730	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:135290730G>T	ENST00000543669.1	+	5	1329	c.618G>T	c.(616-618)caG>caT	p.Q206H	FHL1_ENST00000394153.2_Missense_Mutation_p.Q206H|FHL1_ENST00000394155.2_Missense_Mutation_p.Q206H|FHL1_ENST00000345434.3_Missense_Mutation_p.Q206H|FHL1_ENST00000370676.3_Intron|FHL1_ENST00000535737.1_Missense_Mutation_p.Q206H|FHL1_ENST00000370690.3_Missense_Mutation_p.Q206H|FHL1_ENST00000370683.1_Missense_Mutation_p.Q222H|FHL1_ENST00000539015.1_Missense_Mutation_p.Q235H	NM_001159704.1	NP_001153176.1	Q13642	FHL1_HUMAN	four and a half LIM domains 1	206	LIM zinc-binding 3.				cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(192;0.000127)					TGGAGGACCAGTATTACTGCG	0.517000													273	262					1.66653e-126	2.83885e-126	0.048971	1	0
PARP10	84875	broad.mit.edu	37	8	145058997	145058997	+	Silent	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:145058997A>T	ENST00000313028.7	-	5	1267	c.1173T>A	c.(1171-1173)tcT>tcA	p.S391S	PARP10_ENST00000525773.1_Silent_p.S403S|PARP10_ENST00000524918.1_Silent_p.S391S	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	391						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCAACCCCTTAGAGGTCTCCA	0.637000													92	50					0	0	0.048971	0	0
COL4A5	1287	broad.mit.edu	37	X	107811887	107811887	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:107811887G>T	ENST00000328300.6	+	5	549	c.305G>T	c.(304-306)gGg>gTg	p.G102V	COL4A5_ENST00000361603.2_Missense_Mutation_p.G102V	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	102	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGATTTCCAGGGACACCAGGT	0.328000									Alport syndrome with Diffuse Leiomyomatosis				54	93					1.54043e-34	2.45475e-34	0.048971	1	0
ACSM2A	123876	broad.mit.edu	37	16	20482944	20482944	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:20482944C>A	ENST00000573854.1	+	6	941	c.827C>A	c.(826-828)cCt>cAt	p.P276H	ACSM2A_ENST00000536134.1_Missense_Mutation_p.P48H|ACSM2A_ENST00000575690.1_Missense_Mutation_p.P276H|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.P276H|ACSM2A_ENST00000417235.2_Missense_Mutation_p.P197H|ACSM2A_ENST00000396104.2_Missense_Mutation_p.P276H	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	276					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CTTATGGAACCTTGGGCATTA	0.438000													9	288					3.09899e-07	3.69782e-07	0.047766	1	0
PPP1R32	220004	broad.mit.edu	37	11	61253281	61253281	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:61253281G>T	ENST00000338608.2	+	7	710	c.585G>T	c.(583-585)caG>caT	p.Q195H	PPP1R32_ENST00000432063.2_Missense_Mutation_p.Q195H|RP11-286N22.8_ENST00000544880.1_3'UTR	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	195																	ATTTCTTGCAGAAGAAATCGA	0.602000													12	25					0.000978159	0.00106591	0.080935	1	0
ATR	545	broad.mit.edu	37	3	142281403	142281403	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:142281403C>A	ENST00000350721.4	-	4	962	c.841G>T	c.(841-843)Gta>Tta	p.V281L	ATR_ENST00000383101.3_Missense_Mutation_p.V281L	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	281					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TCCATTTCTACAAGGTGTTTT	0.348000								Other conserved DNA damage response genes					15	32					6.72482e-11	8.60638e-11	0.024245	1	0
LOC101927060	101927060	broad.mit.edu	37	17	45128671	45128671	+	RNA	SNP	T	T	G	rs1056072	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:45128671T>G	ENST00000575173.1	-	0	418																											GCTCACAAAATAAGTTCCAGG	0.323000													5	73					0	0	0.021553	0	0
C6orf118	168090	broad.mit.edu	37	6	165715321	165715321	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:165715321G>A	ENST00000543069.1	-	2	759	c.178C>T	c.(178-180)Cct>Tct	p.P60S	C6orf118_ENST00000230301.8_Missense_Mutation_p.P164S			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	164								p.P164A(1)		breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCCCGTCCAGGAGGGCCTCCT	0.617000													25	16					0	0	0.108266	0	0
KDM4C	23081	broad.mit.edu	37	9	6984340	6984340	+	Silent	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:6984340A>G	ENST00000381309.3	+	10	1855	c.1290A>G	c.(1288-1290)gaA>gaG	p.E430E	KDM4C_ENST00000536108.1_Silent_p.E249E|KDM4C_ENST00000543771.1_Silent_p.E430E|KDM4C_ENST00000535193.1_Silent_p.E452E|KDM4C_ENST00000442236.2_Silent_p.E249E|KDM4C_ENST00000428870.2_Silent_p.E117E|KDM4C_ENST00000381306.3_Silent_p.E430E	NM_015061.3	NP_055876.2	Q9H3R0	KDM4C_HUMAN	lysine (K)-specific demethylase 4C	430					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43						CATCTTCAGAAGAAGAGTCAT	0.458000													72	49					0	0	0.048971	0	0
MARK1	4139	broad.mit.edu	37	1	220805569	220805569	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:220805569C>T	ENST00000402574.1	+	11	1633	c.631C>T	c.(631-633)Cga>Tga	p.R211*	MARK1_ENST00000366917.4_Nonsense_Mutation_p.R346*|MARK1_ENST00000366918.4_Nonsense_Mutation_p.R324*	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	346	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		GGGCTTTGCACGAGATGAAAT	0.313000													40	142					0	0	0.048971	0	0
CLSTN1	22883	broad.mit.edu	37	1	9811657	9811657	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:9811657C>T	ENST00000377298.4	-	5	1315	c.523G>A	c.(523-525)Gag>Aag	p.E175K	CLSTN1_ENST00000361311.4_Missense_Mutation_p.E165K|CLSTN1_ENST00000377288.3_Missense_Mutation_p.E175K	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	175	Cadherin 2.				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		TGCTTCCCCTCGATGACCGTG	0.537000													5	15					0	0	0.014758	0	0
ENPP5	59084	broad.mit.edu	37	6	46129366	46129366	+	Silent	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:46129366T>C	ENST00000371383.2	-	5	1391	c.1131A>G	c.(1129-1131)ctA>ctG	p.L377L	ENPP5_ENST00000230565.3_Silent_p.L377L			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	377						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						GGAGGTGGCATAGTAGTGGGT	0.453000													98	160					0	0	0.048971	0	0
RASA1	5921	broad.mit.edu	37	5	86645181	86645181	+	Splice_Site	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:86645181G>C	ENST00000456692.2	+	8	837	c.722_splice	c.e8+1	p.S241_splice	RASA1_ENST00000506290.1_Splice_Site_p.S252_splice|RASA1_ENST00000274376.6_Splice_Site_p.S418_splice|RASA1_ENST00000512763.1_Splice_Site_p.S251_splice	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	418	SH2 1.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TATTATAACAGGTAAATCATA	0.289000													18	11					0	0	0.043863	0	0
RBBP6	5930	broad.mit.edu	37	16	24578601	24578601	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:24578601C>T	ENST00000319715.4	+	15	2159	c.1727C>T	c.(1726-1728)cCg>cTg	p.P576L	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Missense_Mutation_p.P576L	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	576					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		cctctccctccgggtgttcct	0.587000													32	99					0	0	0.045705	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011536	105011536	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:105011536T>A	ENST00000372582.1	+	11	2699	c.1943T>A	c.(1942-1944)cTa>cAa	p.L648Q	IL1RAPL2_ENST00000538500.1_Missense_Mutation_p.L253Q|IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.L648Q	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	648					central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CCTCTGACGCTACTCAACGGA	0.463000													56	87					0	0	0.048971	0	0
CFL2	1073	broad.mit.edu	37	14	35182632	35182632	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:35182632T>A	ENST00000341223.3	-	2	290	c.139A>T	c.(139-141)Ata>Tta	p.I47L	CFL2_ENST00000555765.1_Missense_Mutation_p.I30L|CFL2_ENST00000298159.6_Missense_Mutation_p.I47L|CFL2_ENST00000556161.1_Missense_Mutation_p.I30L	NM_001243645.1|NM_021914.7	NP_001230574.1|NP_068733.1	Q9Y281	COF2_HUMAN	cofilin 2 (muscle)	47	ADF-H.		I -> M (in a breast cancer sample; somatic mutation).			cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(3)|endometrium(2)|lung(3)	8	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		TCTACAATTATTTGTCTTTTG	0.373000													9	14					0	0	0.058154	0	0
NMD3	51068	broad.mit.edu	37	3	160965079	160965079	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:160965079G>A	ENST00000460469.1	+	12	1619	c.1164G>A	c.(1162-1164)gaG>gaA	p.E388E	NMD3_ENST00000351193.2_Silent_p.E388E|NMD3_ENST00000472947.1_Silent_p.E388E			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	388					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TAAATGATGAGCATGTCAACA	0.343000													19	45					0	0	0.091800	0	0
NAIP	4671	broad.mit.edu	37	5	70308408	70308408	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:70308408A>G	ENST00000517649.1	-	4	625	c.335T>C	c.(334-336)cTc>cCc	p.L112P	NAIP_ENST00000508426.2_Missense_Mutation_p.L112P|NAIP_ENST00000503719.2_Intron|NAIP_ENST00000194097.4_Missense_Mutation_p.L112P|NAIP_ENST00000523981.1_Intron	NM_004536.2	NP_004527.2	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein	112					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TTCTATGGGGAGTCTCGTGAG	0.493000													9	26					0	0	0.058154	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044192	90044192	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:90044192C>A	ENST00000462693.1	+	0	143																											CTTGGACAGCCGGCCTCCATC	0.522000													83	142					1.02218e-41	1.6647e-41	0.048971	1	0
F10	2159	broad.mit.edu	37	13	113798342	113798342	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:113798342G>T	ENST00000375559.3	+	6	718	c.680G>T	c.(679-681)aGg>aTg	p.R227M	F10_ENST00000409306.1_Missense_Mutation_p.R227M|F10_ENST00000375551.3_Missense_Mutation_p.R227M	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	227					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCCTGAGAGGGGCGACAAC	0.612000													6	14					0.000157383	0.000174582	0.038147	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885200	88885200	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:88885200G>T	ENST00000319675.3	-	1	1096	c.1000C>A	c.(1000-1002)Cag>Aag	p.Q334K		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	334										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						TAGCAGTCCTGGCCCACGGCC	0.572000													6	39					0.000673444	0.000737108	0.069234	1	0
EPHA10	284656	broad.mit.edu	37	1	38227328	38227328	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:38227328G>A	ENST00000373048.4	-	3	598	c.599C>T	c.(598-600)gCg>gTg	p.A200V	EPHA10_ENST00000319637.6_Missense_Mutation_p.A200V|EPHA10_ENST00000427468.2_Missense_Mutation_p.A200V	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	200						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGAGACAAGCGCCACGCATGC	0.672000													5	29					0	0	0.029380	0	0
ZNF792	126375	broad.mit.edu	37	19	35449248	35449248	+	Missense_Mutation	SNP	C	C	G	rs142139829		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:35449248C>G	ENST00000404801.1	-	4	1897	c.1511G>C	c.(1510-1512)cGg>cCg	p.R504P	ZNF792_ENST00000605484.1_Missense_Mutation_p.R437P	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CTGGTAAGGCCGTTCACCAGT	0.512000													30	83					0	0	0.030593	0	0
KAT6B	23522	broad.mit.edu	37	10	76784747	76784747	+	Missense_Mutation	SNP	G	G	A	rs138617006	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:76784747G>A	ENST00000287239.4	+	17	3893	c.3404G>A	c.(3403-3405)cGt>cAt	p.R1135H	KAT6B_ENST00000372714.1_Missense_Mutation_p.R843H|KAT6B_ENST00000372711.1_Missense_Mutation_p.R952H|KAT6B_ENST00000372724.1_Missense_Mutation_p.R843H|RP11-77G23.2_ENST00000413431.1_RNA|KAT6B_ENST00000372725.1_Missense_Mutation_p.R843H|KAT6B_ENST00000490365.1_3'UTR	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1135					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										AAAAGGGGTCGTAAACGCAGG	0.408000													27	86					0	0	0.041601	0	0
LOC151121	151121	broad.mit.edu	37	2	130000227	130000227	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:130000227C>A	ENST00000375987.3	-	0	1731																											TGAGGCAAGActgggaacagc	0.572000													7	4					0.0293803	0.0301953	0.029380	1	0
OR6C2	341416	broad.mit.edu	37	12	55846562	55846562	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:55846562G>T	ENST00000322678.1	+	1	565	c.565G>T	c.(565-567)Gat>Tat	p.D189Y	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_054105.1	NP_473446.1	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C, member 2	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(5)|lung(8)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	23						CTCATGCTCAGATACATGGGT	0.423000													119	56					4.24233e-61	7.06419e-61	0.048971	1	0
GATS	352954	broad.mit.edu	37	7	99869494	99869494	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:99869494A>G	ENST00000436886.2	-	1	361	c.113T>C	c.(112-114)cTg>cCg	p.L38P	GATS_ENST00000543273.1_RNA	NM_178831.6	NP_849153.3	Q8NAP1	GATS_HUMAN		38										endometrium(2)|large_intestine(2)|lung(4)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AAGTTTGATCAGGCCCGTAGG	0.672000													3	8					0	0	0.014758	0	0
CHRNB4	1143	broad.mit.edu	37	15	78917468	78917468	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:78917468G>T	ENST00000412074.2	-	5	636	c.525C>A	c.(523-525)ccC>ccA	p.P175P	CHRNB4_ENST00000261751.3_3'UTR	NM_001256567.1	NP_001243496.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	0					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CACAACCCAGGGGGCCCTCAG	0.607000													20	21					1.66031e-10	2.11027e-10	0.091800	1	0
P2RY4	5030	broad.mit.edu	37	X	69479165	69479165	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:69479165C>A	ENST00000374519.2	-	1	489	c.310G>T	c.(310-312)Ggc>Tgc	p.G104C		NM_002565.3	NP_002556.1	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 4	104					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(2)|endometrium(2)|large_intestine(8)|lung(6)	18						ATCTCAGTGCCAAAGGGCCAG	0.532000													6	105					0.0215528	0.0222742	0.021553	1	0
DCLRE1A	9937	broad.mit.edu	37	10	115609684	115609684	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:115609684T>A	ENST00000361384.2	-	2	2097	c.1180A>T	c.(1180-1182)Agt>Tgt	p.S394C	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.S394C	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	394					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GGCAAAGTACTCTCATTATTT	0.388000								Other identified genes with known or suspected DNA repair function					7	35					0	0	0.038147	0	0
CEP170	9859	broad.mit.edu	37	1	243362482	243362482	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:243362482G>A	ENST00000366542.1	-	7	562	c.511C>T	c.(511-513)Ccc>Tcc	p.P171S	CEP170_ENST00000366543.1_Missense_Mutation_p.P171S|CEP170_ENST00000366544.1_Missense_Mutation_p.P171S	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	171						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GTACCACGGGGCATAGCAGAA	0.428000													8	58					0	0	0.080935	0	0
STAB2	55576	broad.mit.edu	37	12	104121076	104121076	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:104121076G>T	ENST00000388887.2	+	47	5087	c.4883G>T	c.(4882-4884)gGc>gTc	p.G1628V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1628	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTCGGCCCAGGCCCCTTCACT	0.522000													29	385					5.45727e-16	7.55857e-16	0.037714	1	0
HEPHL1	341208	broad.mit.edu	37	11	93797496	93797496	+	Splice_Site	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:93797496G>A	ENST00000315765.9	+	4	636		c.e4-1			NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1						copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTGCCTGACAGGTATCCTGAA	0.403000													27	48					0	0	0.050027	0	0
GRB7	2886	broad.mit.edu	37	17	37903138	37903138	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:37903138G>A	ENST00000309156.4	+	15	1844	c.1587G>A	c.(1585-1587)cgG>cgA	p.R529R	GRB7_ENST00000394204.1_3'UTR|GRB7_ENST00000445327.2_Silent_p.R552R|GRB7_ENST00000309185.3_3'UTR|GRB7_ENST00000394209.2_Silent_p.R529R|GRB7_ENST00000394211.3_Silent_p.R529R	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	529					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCTGCACGCGGGTGGCCCTCT	0.687000													4	6					0	0	0.009096	0	0
MYLK3	91807	broad.mit.edu	37	16	46766387	46766387	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:46766387C>A	ENST00000394809.4	-	4	1310	c.1195G>T	c.(1195-1197)Gag>Tag	p.E399*	MYLK3_ENST00000536476.1_Nonsense_Mutation_p.E58*	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	399					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGGGAGAGCTCTCTGGCTCCT	0.697000													12	15					3.27435e-08	3.99719e-08	0.020292	1	0
COL16A1	1307	broad.mit.edu	37	1	32164183	32164183	+	Silent	SNP	C	C	T	rs76478494	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:32164183C>T	ENST00000373672.3	-	5	807	c.291G>A	c.(289-291)ccG>ccA	p.P97P	COL16A1_ENST00000271069.6_Silent_p.P97P|COL16A1_ENST00000373668.3_Silent_p.P97P	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	97	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CAAACTCCTCCGGGAGACCCC	0.567000													14	47					0	0	0.020292	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227219179	227219179	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:227219179A>G	ENST00000366769.3	-	27	4781	c.3490T>C	c.(3490-3492)Tgt>Cgt	p.C1164R	CDC42BPA_ENST00000366764.2_Missense_Mutation_p.C1136R|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.C1199R|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.C1144R|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.C1177R|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.C1164R|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.C1083R	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1177	PH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				AGGATTGAACATTTGTTATTA	0.368000													60	130					0	0	0.048971	0	0
KIF6	221458	broad.mit.edu	37	6	39563849	39563849	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:39563849G>C	ENST00000287152.7	-	7	921	c.827C>G	c.(826-828)tCa>tGa	p.S276*	KIF6_ENST00000373216.3_Nonsense_Mutation_p.S276*|KIF6_ENST00000538893.1_Nonsense_Mutation_p.S276*|KIF6_ENST00000373213.4_Nonsense_Mutation_p.S115*|KIF6_ENST00000373215.3_Nonsense_Mutation_p.S276*	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	276					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GTAATGTAGTGACAAGTTGAT	0.433000													33	57					0	0	0.069456	0	0
NWD1	284434	broad.mit.edu	37	19	16902383	16902383	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:16902383C>A	ENST00000524140.2	+	14	3581	c.3163C>A	c.(3163-3165)Cag>Aag	p.Q1055K	NWD1_ENST00000552788.1_Missense_Mutation_p.Q1055K|NWD1_ENST00000523826.1_Missense_Mutation_p.Q849K|NWD1_ENST00000379808.3_Missense_Mutation_p.Q1055K|NWD1_ENST00000339803.6_Missense_Mutation_p.Q920K|NWD1_ENST00000549814.1_Missense_Mutation_p.Q1055K	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1055							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CGTCTCAGTCCAGAAGCAAGG	0.468000													3	26					0.004672	0.00493156	0.004672	1	0
DSP	1832	broad.mit.edu	37	6	7583538	7583538	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:7583538G>A	ENST00000379802.3	+	24	6384	c.6043G>A	c.(6043-6045)Gca>Aca	p.A2015T	DSP_ENST00000418664.2_Missense_Mutation_p.A1416T	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2015	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCTTCGGGGTGCAGGATCTAT	0.453000													9	47					0	0	0.069234	0	0
SNHG14	104472715	broad.mit.edu	37	15	25318309	25318309	+	RNA	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:25318309G>C	ENST00000549804.2	+	0	817				SNHG14_ENST00000551077.1_RNA|SNORD116-9_ENST00000384000.1_RNA																							AACAAAATGAGTGAGAACTCA	0.453000													8	151					0	0	0.058154	0	0
RREB1	6239	broad.mit.edu	37	6	7230227	7230227	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:7230227G>T	ENST00000379938.2	+	10	2432	c.1895G>T	c.(1894-1896)gGc>gTc	p.G632V	RREB1_ENST00000379933.3_Missense_Mutation_p.G632V|RREB1_ENST00000334984.6_Missense_Mutation_p.G632V|RREB1_ENST00000349384.6_Missense_Mutation_p.G632V	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	632					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GCGCCCGGCGGCAAGAAGACG	0.637000													11	14					1.61879e-10	2.06104e-10	0.093190	1	0
CXorf64	100130613	broad.mit.edu	37	X	125955175	125955175	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:125955175C>T	ENST00000371125.3	+	2	634	c.554C>T	c.(553-555)cCc>cTc	p.P185L		NM_001122716.1	NP_001116188.1	B1ATL7	CX064_HUMAN	chromosome X open reading frame 64	185																	TCACATATTCCCACCCTTAGA	0.527000													7	8					0	0	0.038147	0	0
MMP7	4316	broad.mit.edu	37	11	102394103	102394103	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:102394103C>A	ENST00000260227.4	-	5	695	c.643G>T	c.(643-645)Gaa>Taa	p.E215*		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	215					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		TGGCCAAGTTCATGAGTTGCA	0.358000													16	100					1.33834e-09	1.67802e-09	0.043863	1	0
FHOD3	80206	broad.mit.edu	37	18	34298194	34298194	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:34298194A>T	ENST00000257209.4	+	16	2530	c.2408A>T	c.(2407-2409)tAc>tTc	p.Y803F	FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000359247.4_Missense_Mutation_p.Y786F|FHOD3_ENST00000590592.1_Missense_Mutation_p.Y978F|FHOD3_ENST00000445677.1_Missense_Mutation_p.Y765F	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	786					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GAGTCTGATTACATCTGGGAC	0.542000													45	189					0	0	0.048971	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604808	58604808	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:58604808G>C	ENST00000287275.1	-	4	639	c.249C>G	c.(247-249)gaC>gaG	p.D83E	GLYATL2_ENST00000532258.1_Missense_Mutation_p.D83E|GLYATL2_ENST00000533636.1_5'UTR	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	83						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	CCTCTAATTTGTCAGGAGCTT	0.373000													30	57					0	0	0.030593	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62604607	62604607	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:62604607C>A	ENST00000281156.4	-	6	1021	c.743G>T	c.(742-744)cGg>cTg	p.R248L		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	248	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGGTGCCCCCCGGGCTCGAGG	0.557000													15	71					0.00316338	0.00335826	0.024245	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29908169	29908169	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:29908169G>T	ENST00000308713.5	-	3	1012	c.485C>A	c.(484-486)aCt>aAt	p.T162N	SEZ6L2_ENST00000562159.1_5'UTR|SEZ6L2_ENST00000350527.3_Missense_Mutation_p.T92N|SEZ6L2_ENST00000346932.5_Missense_Mutation_p.T162N|SEZ6L2_ENST00000537485.1_Missense_Mutation_p.T118N	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	162	Thr-rich.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGTGGTAACAGTTGTCGTGGT	0.662000													14	16					2.5808e-16	3.58794e-16	0.038395	1	0
PRAMEF4	400735	broad.mit.edu	37	1	12939641	12939641	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:12939641G>T	ENST00000235349.5	-	4	1231	c.1161C>A	c.(1159-1161)ttC>ttA	p.F387L		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	387										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATTTCCACAGAAGCTGAAGG	0.527000													133	154					4.64668e-71	7.79002e-71	0.048971	1	0
CCT8L2	150160	broad.mit.edu	37	22	17072422	17072422	+	Missense_Mutation	SNP	G	G	T	rs148571019		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:17072422G>T	ENST00000359963.3	-	1	1278	c.1019C>A	c.(1018-1020)cCt>cAt	p.P340H		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	340					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCTCTGGGGAGGGAGCAGACG	0.552000													21	33					2.61193e-14	3.53828e-14	0.041601	1	0
ZNF75D	7626	broad.mit.edu	37	X	134421668	134421668	+	Missense_Mutation	SNP	G	G	T	rs150700463	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:134421668G>T	ENST00000370766.3	-	7	3643	c.934C>A	c.(934-936)Cag>Aag	p.Q312K	ZNF75D_ENST00000494295.1_Intron|ZNF75D_ENST00000370764.1_Missense_Mutation_p.Q217K	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	312	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						ATTGTTTTCTGGGCAATTTTC	0.373000													29	155					5.77227e-19	8.40325e-19	0.037714	1	0
FAM71B	153745	broad.mit.edu	37	5	156590312	156590312	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:156590312C>T	ENST00000302938.4	-	2	1059	c.964G>A	c.(964-966)Gga>Aga	p.G322R		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	322						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCATTTTCTCCTGGATTTTTG	0.527000													31	44					0	0	0.064281	0	0
BRWD3	254065	broad.mit.edu	37	X	79975018	79975018	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:79975018G>A	ENST00000373275.4	-	18	2230	c.2014C>T	c.(2014-2016)Cca>Tca	p.P672S	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	672										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CTATTAACTGGTAAATGTGGA	0.333000													15	42					0	0	0.038395	0	0
OSR2	116039	broad.mit.edu	37	8	99961221	99961221	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:99961221C>A	ENST00000297565.4	+	2	537	c.41C>A	c.(40-42)cCg>cAg	p.P14Q	OSR2_ENST00000522510.1_Missense_Mutation_p.P14Q|OSR2_ENST00000435298.2_Missense_Mutation_p.P14Q|OSR2_ENST00000523368.1_Missense_Mutation_p.P14Q|OSR2_ENST00000457907.2_Missense_Mutation_p.P135Q	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	14					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CCGCTCCACCCGTCGCTGCAG	0.647000													36	19					1.04594e-18	1.50786e-18	0.086207	1	0
MKI67	4288	broad.mit.edu	37	10	129903163	129903163	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:129903163T>C	ENST00000368654.3	-	13	7316	c.6941A>G	c.(6940-6942)gAa>gGa	p.E2314G	MKI67_ENST00000368653.3_Missense_Mutation_p.E1954G	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2314	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AGCCAGGTCTTCTAGAGCCTG	0.493000													43	140					0	0	0.098360	0	0
NBEA	26960	broad.mit.edu	37	13	36046595	36046595	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:36046595G>T	ENST00000540320.1	+	41	7041	c.6507G>T	c.(6505-6507)ggG>ggT	p.G2169G	NBEA_ENST00000310336.4_Silent_p.G2169G|NBEA_ENST00000400445.3_Silent_p.G2169G|NBEA_ENST00000379939.2_Silent_p.G2166G			Q8NFP9	NBEA_HUMAN	neurobeachin	2169						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGGCCAAGGGGACTCTCTCCA	0.557000													13	22					4.3838e-07	5.18913e-07	0.105934	1	0
FLG	2312	broad.mit.edu	37	1	152279608	152279608	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152279608C>A	ENST00000368799.1	-	3	7789	c.7754G>T	c.(7753-7755)gGg>gTg	p.G2585V	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2585	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAAGCAGACCCAGACCACCT	0.557000									Ichthyosis				86	108					9.70916e-65	1.62038e-64	0.048971	1	0
PCDH11X	27328	broad.mit.edu	37	X	91133598	91133598	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:91133598C>A	ENST00000373094.1	+	2	3204	c.2359C>A	c.(2359-2361)Cgc>Agc	p.R787S	PCDH11X_ENST00000395337.2_Missense_Mutation_p.R787S|PCDH11X_ENST00000406881.1_Missense_Mutation_p.R787S|PCDH11X_ENST00000373097.1_Missense_Mutation_p.R787S|PCDH11X_ENST00000361724.1_Missense_Mutation_p.R787S|PCDH11X_ENST00000373088.1_Missense_Mutation_p.R787S|PCDH11X_ENST00000361655.2_Missense_Mutation_p.R787S|PCDH11X_ENST00000298274.8_Missense_Mutation_p.R787S|PCDH11X_ENST00000504220.1_Missense_Mutation_p.R787S	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	787	Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGAACTGGTGCGCAAAAGCAC	0.448000													81	103					3.1711e-36	5.08611e-36	0.048971	1	0
GPAT2	150763	broad.mit.edu	37	2	96688465	96688465	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:96688465G>A	ENST00000434632.1	-	22	2681	c.2222C>T	c.(2221-2223)gCg>gTg	p.A741V	GPAT2_ENST00000377137.3_Missense_Mutation_p.R657W|GPAT2_ENST00000453542.1_Missense_Mutation_p.A670V|GPAT2_ENST00000359548.4_Missense_Mutation_p.A741V			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	741					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						CTTTGGGTCCGCACACTCTGG	0.557000													4	135					0	0	0.014758	0	0
AMHR2	269	broad.mit.edu	37	12	53824052	53824052	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:53824052C>T	ENST00000257863.4	+	10	1491	c.1411C>T	c.(1411-1413)Cgc>Tgc	p.R471C	AMHR2_ENST00000550311.1_Silent_p.G469G|AMHR2_ENST00000379791.3_Intron	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	471	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	ATCCACCTGGCGCTGCTTTGC	0.597000													21	83					0	0	0.062417	0	0
PDE4A	5141	broad.mit.edu	37	19	10565513	10565513	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:10565513G>C	ENST00000380702.2	+	8	726	c.726G>C	c.(724-726)agG>agC	p.R242S	PDE4A_ENST00000592685.1_Missense_Mutation_p.R242S|PDE4A_ENST00000440014.2_Missense_Mutation_p.R203S|PDE4A_ENST00000344979.3_Missense_Mutation_p.R25S|PDE4A_ENST00000293683.5_Missense_Mutation_p.R238S|PDE4A_ENST00000352831.6_Missense_Mutation_p.R264S			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	264					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	AGTTCAAAAGGATGTTGAACC	0.507000													58	79					0	0	0.048971	0	0
OR2W5	441932	broad.mit.edu	37	1	247654449	247654449	+	RNA	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:247654449G>A	ENST00000522351.1	+	0	80							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GACAATGCCAGTTACCTACAG	0.468000													34	81					0	0	0.069456	0	0
LOC440040	440040	broad.mit.edu	37	11	49831322	49831322	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:49831322C>A	ENST00000527477.1	+	0	1547																											ATAATGAAGCCAACAGTCATA	0.318000													14	11					9.05144e-12	1.17053e-11	0.105934	1	0
MT-CYB	4519	broad.mit.edu	37	MT	15887	15887	+	Splice_Site	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:15887T>C	ENST00000361789.2	+	1	1141	c.1141_splice	c.e1+1	p.381_splice	MT-TT_ENST00000387460.2_RNA					mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						TCAAATGGGCCTGTCCTTGTA	0.368000													7	508					0	0	0.038147	0	0
ASTN2	23245	broad.mit.edu	37	9	119582901	119582901	+	Translation_Start_Site	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:119582901G>T	ENST00000361477.3	-	0	2149				ASTN2_ENST00000361209.2_Missense_Mutation_p.F683L|ASTN2_ENST00000373996.3_Missense_Mutation_p.F730L|ASTN2_ENST00000313400.4_Missense_Mutation_p.F734L			O75129	ASTN2_HUMAN	astrotactin 2							integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CTCACCCGCAGAACATGAAGA	0.562000													42	111					2.24893e-16	3.13834e-16	0.111260	1	0
IGKV3D-20	28874	broad.mit.edu	37	2	90078039	90078039	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:90078039C>A	ENST00000390270.2	+	0	173																											TGTGTTGACGCAGTCTCCAGC	0.502000													59	99					6.83704e-37	1.10136e-36	0.048971	1	0
PIK3C2A	5286	broad.mit.edu	37	11	17115871	17115871	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:17115871A>C	ENST00000265970.7	-	27	4387	c.4388T>G	c.(4387-4389)tTt>tGt	p.F1463C	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.F1083C|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1463	PX.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	AAATTCGTCAAATGTTCGGAA	0.333000													4	2					0	0	0.014758	0	0
HHIP	64399	broad.mit.edu	37	4	145628274	145628274	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:145628274G>T	ENST00000296575.3	+	6	1674	c.1019G>T	c.(1018-1020)aGa>aTa	p.R340I		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	340						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		AGAACAGCCAGAGTCTTTCTT	0.413000													16	75					0.0332995	0.0341758	0.033300	1	0
FAM114A2	10827	broad.mit.edu	37	5	153406765	153406765	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:153406765C>A	ENST00000351797.4	-	7	836	c.760G>T	c.(760-762)Gag>Tag	p.E254*	FAM114A2_ENST00000520313.1_Nonsense_Mutation_p.E184*|FAM114A2_ENST00000522858.1_Nonsense_Mutation_p.E254*|FAM114A2_ENST00000520667.1_Nonsense_Mutation_p.E254*	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	254							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						GAAAGCATCTCCAGAGCTTCT	0.398000													32	32					8.73648e-17	1.22609e-16	0.069456	1	0
OR8B3	390271	broad.mit.edu	37	11	124267113	124267113	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:124267113C>A	ENST00000354597.3	-	1	151	c.135G>T	c.(133-135)ttG>ttT	p.L45F		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAAGAATGATCAAGCCAAGGT	0.418000													52	101					2.05175e-36	3.29794e-36	0.048971	1	0
DIDO1	11083	broad.mit.edu	37	20	61542314	61542314	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:61542314C>A	ENST00000266070.4	-	3	976	c.651G>T	c.(649-651)caG>caT	p.Q217H	DIDO1_ENST00000354665.4_Missense_Mutation_p.Q217H|DIDO1_ENST00000395335.2_Missense_Mutation_p.Q217H|DIDO1_ENST00000370371.4_Missense_Mutation_p.Q217H|DIDO1_ENST00000266071.5_Missense_Mutation_p.Q217H|DIDO1_ENST00000395340.1_Missense_Mutation_p.Q217H|DIDO1_ENST00000370368.1_Missense_Mutation_p.Q217H|DIDO1_ENST00000395343.1_Missense_Mutation_p.Q217H|DIDO1_ENST00000370366.1_Missense_Mutation_p.Q217H	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	217					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCTCGGGCTCCTGCTTACTGG	0.622000													7	32					3.86212e-05	4.34929e-05	0.069234	1	0
TNRC18	84629	broad.mit.edu	37	7	5360212	5360212	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:5360212C>G	ENST00000399537.4	-	23	6935	c.6587G>C	c.(6586-6588)cGg>cCg	p.R2196P	TNRC18_ENST00000430969.1_Missense_Mutation_p.R2196P			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2196							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCGGTTGCCCCGCTCACCCTC	0.692000													10	16					0	0	0.093190	0	0
PRRC2A	7916	broad.mit.edu	37	6	31603426	31603426	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:31603426A>C	ENST00000376033.2	+	24	5675	c.5441A>C	c.(5440-5442)aAg>aCg	p.K1814T	PRRC2A_ENST00000376007.4_Missense_Mutation_p.K1814T	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1814						cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCACAATCCAAGAACCTGGAT	0.597000													9	47					0	0	0.024245	0	0
WDFY4	57705	broad.mit.edu	37	10	49994685	49994685	+	Splice_Site	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:49994685T>A	ENST00000325239.5	+	19	3605	c.3576_splice	c.e19-1	p.M1193_splice	WDFY4_ENST00000413659.2_Intron	NM_020945.1	NP_065996.1	Q6ZS81	WDFY4_HUMAN	WDFY family member 4	1193						integral to membrane	binding			NS(2)|breast(5)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(3)|pancreas(2)|prostate(5)|skin(6)|stomach(1)	48						TTTTAACAGATGTTATACATC	0.368000													3	10					0	0	0.004672	0	0
SETX	23064	broad.mit.edu	37	9	135205501	135205501	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:135205501A>G	ENST00000372169.2	-	10	1666	c.1484T>C	c.(1483-1485)cTt>cCt	p.L495P	SETX_ENST00000224140.5_Missense_Mutation_p.L495P|SETX_ENST00000393220.1_Missense_Mutation_p.L495P			Q7Z333	SETX_HUMAN	senataxin	495					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AGTGGTAGGAAGCTTGGCACA	0.428000													6	123					0	0	0.038147	0	0
FZD4	8322	broad.mit.edu	37	11	86662549	86662549	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:86662549G>A	ENST00000531380.1	-	2	1554	c.1249C>T	c.(1249-1251)Cgg>Tgg	p.R417W	PRSS23_ENST00000533902.2_3'UTR|PRSS23_ENST00000531521.1_3'UTR	NM_012193.3	NP_036325.2	Q9ULV1	FZD4_HUMAN	frizzled family receptor 4	417			R -> Q (in EVR1; 48% loss of its wild- type activity; associated in a EVR4 patient with mutation CYS-444 in LPR5).		canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(6)|skin(1)	21		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGATTTGACCGAATTTTGAAC	0.463000													12	78					0	0	0.093190	0	0
BAGE2	85319	broad.mit.edu	37	21	11039060	11039060	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:11039060G>T	ENST00000470054.1	-	0	1143									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATCAATCCAGTAGAAAGTTC	0.398000													14	451					0.0167234	0.0173558	0.105934	1	0
NAALAD2	10003	broad.mit.edu	37	11	89880659	89880659	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:89880659C>T	ENST00000534061.1	+	3	586	c.356C>T	c.(355-357)tCg>tTg	p.S119L	NAALAD2_ENST00000321955.4_Missense_Mutation_p.S119L|NAALAD2_ENST00000375944.3_Missense_Mutation_p.S119L|NAALAD2_ENST00000525171.1_Missense_Mutation_p.S119L	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	119					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AACTATATATCGATTGTGGAT	0.368000													4	93					0	0	0.009096	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176359	142176359	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:142176359G>T	ENST00000390369.2	-	0	316																											ATACACAGCTGAGTCCCCCTG	0.567000													39	110					1.04594e-18	1.50786e-18	0.086207	1	0
TMEM86A	144110	broad.mit.edu	37	11	18723452	18723452	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:18723452G>C	ENST00000280734.2	+	3	715	c.619G>C	c.(619-621)Gcg>Ccg	p.A207P		NM_153347.1	NP_699178.1	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	207						integral to membrane				endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	11						CTACTCTCGGGCGCTTATCAT	0.547000													42	19					0	0	0.048971	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14799107	14799107	+	Silent	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:14799107T>A	ENST00000358984.4	+	21	2217	c.2037T>A	c.(2035-2037)ccT>ccA	p.P679P	ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	730										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TAGAGTCTCCTGATAATGATG	0.284000													4	48					0	0	0.009096	0	0
TRPC1	7220	broad.mit.edu	37	3	142523308	142523308	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:142523308C>G	ENST00000273482.6	+	11	2279	c.1888C>G	c.(1888-1890)Cga>Gga	p.R630G	TRPC1_ENST00000476941.1_Missense_Mutation_p.R664G	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	664					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						GAAGTTTGCTCGAGCAAAATT	0.348000													15	80					0	0	0.028581	0	0
HTR1B	3351	broad.mit.edu	37	6	78172078	78172078	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:78172078A>T	ENST00000369947.2	-	1	1412	c.1043T>A	c.(1042-1044)cTa>cAa	p.L348Q		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	348					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	AAAGATGGCTAGGTGGAACCA	0.458000													6	17					0	0	0.021553	0	0
DDX4	54514	broad.mit.edu	37	5	55075873	55075873	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:55075873G>C	ENST00000505374.1	+	8	568	c.476G>C	c.(475-477)gGa>gCa	p.G159A	DDX4_ENST00000354991.5_Intron|DDX4_ENST00000511853.1_Intron|DDX4_ENST00000514278.2_Missense_Mutation_p.G139A|DDX4_ENST00000353507.5_Intron	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	159	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGCCGTGGAGGATTTGGTCTA	0.378000													4	33					0	0	0.009096	0	0
SLC44A5	204962	broad.mit.edu	37	1	75699718	75699718	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:75699718C>A	ENST00000370855.5	-	12	919	c.806G>T	c.(805-807)tGc>tTc	p.C269F	SLC44A5_ENST00000370859.3_Missense_Mutation_p.C269F|SLC44A5_ENST00000535611.1_Missense_Mutation_p.C139F	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	269						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						CCAGAAGAGGCATCCAGCTAT	0.378000													28	100					3.65163e-15	5.02014e-15	0.030593	1	0
RC3H1	149041	broad.mit.edu	37	1	173939679	173939679	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:173939679C>T	ENST00000367696.2	-	9	1649	c.1298G>A	c.(1297-1299)aGc>aAc	p.S433N	RC3H1_ENST00000258349.4_Missense_Mutation_p.S433N|RC3H1_ENST00000367694.2_Missense_Mutation_p.S433N			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	433					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						AAATGTACAGCTGGCCCCACG	0.428000													54	66					0	0	0.048971	0	0
TMEM67	91147	broad.mit.edu	37	8	94777668	94777668	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:94777668A>T	ENST00000453321.3	+	5	599	c.541A>T	c.(541-543)Agc>Tgc	p.S181C	TMEM67_ENST00000409623.3_Missense_Mutation_p.S100C	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	181					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			TGTTAATACCAGCAGGTCCTG	0.294000													14	97					0	0	0.038395	0	0
TMEM171	134285	broad.mit.edu	37	5	72419493	72419493	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:72419493A>G	ENST00000454765.2	+	2	766	c.293A>G	c.(292-294)gAc>gGc	p.D98G	TMEM171_ENST00000287773.5_Missense_Mutation_p.D98G			Q8WVE6	TM171_HUMAN	transmembrane protein 171	98						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		ATGGACCCCGACCGAGCCTTC	0.607000													6	34					0	0	0.038147	0	0
NDP	4693	broad.mit.edu	37	X	43809121	43809121	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:43809121C>T	ENST00000378062.5	-	3	733	c.326G>A	c.(325-327)cGa>cAa	p.R109Q	NDP-AS1_ENST00000435093.1_RNA|NDP_ENST00000470584.1_5'UTR	NM_000266.3	NP_000257.1	Q00604	NDP_HUMAN	Norrie disease (pseudoglioma)	109	CTCK.				canonical Wnt receptor signaling pathway|cell proliferation|cell-cell signaling|nervous system development|positive regulation of transcription, DNA-dependent|sensory perception of sound|vacuole organization|visual perception	extracellular matrix|extracellular space	cell surface binding|frizzled binding|growth factor activity|protein homodimerization activity			kidney(1)|lung(2)	3						CCCTGAGCATCGCAGCCGCAG	0.602000											OREG0019744	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11					0	0	0.029380	0	0
FSIP2	401024	broad.mit.edu	37	2	186656377	186656377	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:186656377C>A	ENST00000343098.5	+	16	4781	c.4781C>A	c.(4780-4782)gCa>gAa	p.A1594E	FSIP2_ENST00000424728.1_Missense_Mutation_p.A1505E|AC008174.3_ENST00000429929.1_RNA|AC008174.3_ENST00000436557.1_RNA	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						ACCAGTTTTGCAAGTTGTGGA	0.353000													5	8					1.23904e-05	1.41251e-05	0.014758	1	0
PPP3CA	5530	broad.mit.edu	37	4	101947137	101947137	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:101947137G>A	ENST00000394854.3	-	14	2134	c.1451C>T	c.(1450-1452)cCg>cTg	p.P484L	PPP3CA_ENST00000507176.1_Missense_Mutation_p.P386L|PPP3CA_ENST00000394853.4_Missense_Mutation_p.P474L|PPP3CA_ENST00000323055.6_Missense_Mutation_p.P432L|PPP3CA_ENST00000512215.1_Missense_Mutation_p.P252L|PPP3CA_ENST00000523694.2_Missense_Mutation_p.P417L	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	484	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		TCTGCGAGGCGGCATCCTCTC	0.473000													34	195					0	0	0.050027	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773662	140773662	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140773662G>T	ENST00000398604.2	+	1	1282	c.1282G>T	c.(1282-1284)Gga>Tga	p.G428*	PCDHGB4_ENST00000519479.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGATCTAGGAACACCACC	0.418000													8	9					5.4927e-09	6.76095e-09	0.047766	1	0
SPAG9	9043	broad.mit.edu	37	17	49098727	49098727	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:49098727C>A	ENST00000262013.7	-	7	992		c.e7-1		SPAG9_ENST00000505279.1_Splice_Site|SPAG9_ENST00000510283.1_Splice_Site|SPAG9_ENST00000357122.4_Splice_Site	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9						positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AAAGCTCATCCTACaaataaa	0.323000													19	38					6.94344e-10	8.78002e-10	0.038395	1	0
CMYA5	202333	broad.mit.edu	37	5	79032882	79032882	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:79032882A>G	ENST00000446378.2	+	2	8325	c.8294A>G	c.(8293-8295)aAa>aGa	p.K2765R		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2765						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAACAGTTCAAAGAGTCAGAG	0.383000													4	131					0	0	0.009096	0	0
CD40	958	broad.mit.edu	37	20	44757607	44757607	+	Silent	SNP	T	T	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:44757607T>G	ENST00000372285.3	+	9	834	c.762T>G	c.(760-762)acT>acG	p.T254T	CD40_ENST00000372276.3_3'UTR|CD40_ENST00000489304.1_3'UTR	NM_001250.4	NP_001241.1	P25942	TNR5_HUMAN	CD40 molecule, TNF receptor superfamily member 5	254					B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TGCAGGAGACTTTACATGGAT	0.597000									Immune Deficiency with Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	43					0	0	0.083992	0	0
MYO1A	4640	broad.mit.edu	37	12	57440853	57440853	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:57440853A>T	ENST00000442789.2	-	7	756	c.469T>A	c.(469-471)Tcc>Acc	p.S157T	MYO1A_ENST00000544473.1_Intron|MYO1A_ENST00000300119.3_Missense_Mutation_p.S157T	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	157	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						ACAAATCGGGAGGAATTGTTG	0.527000													68	21					0	0	0.048971	0	0
CAMK2A	815	broad.mit.edu	37	5	149636358	149636358	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:149636358G>T	ENST00000348628.6	-	5	974	c.309C>A	c.(307-309)gcC>gcA	p.A103A	CAMK2A_ENST00000398376.3_Silent_p.A103A	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	103	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATACTCCCGGGCCACGATAT	0.597000													22	14					1.75199e-13	2.33493e-13	0.034045	1	0
GRM1	2911	broad.mit.edu	37	6	146351044	146351044	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:146351044C>T	ENST00000392299.2	+	2	861	c.391C>T	c.(391-393)Cga>Tga	p.R131*	GRM1_ENST00000282753.1_Nonsense_Mutation_p.R131*|GRM1_ENST00000507907.1_Nonsense_Mutation_p.R131*|GRM1_ENST00000492807.2_Nonsense_Mutation_p.R131*|GRM1_ENST00000361719.2_Nonsense_Mutation_p.R131*|GRM1_ENST00000355289.4_Nonsense_Mutation_p.R131*			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	131					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GATTTCCATTCGAGATGAGAA	0.582000													16	40					0	0	0.028581	0	0
ASXL3	80816	broad.mit.edu	37	18	31320076	31320076	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:31320076A>T	ENST00000269197.5	+	11	2708	c.2708A>T	c.(2707-2709)cAg>cTg	p.Q903L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	903					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GCTAAATTACAGGACAAGCAA	0.378000													14	79					0	0	0.020292	0	0
KCNH4	23415	broad.mit.edu	37	17	40330185	40330185	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:40330185C>T	ENST00000264661.3	-	4	850	c.518G>A	c.(517-519)cGt>cAt	p.R173H	KCNH4_ENST00000607371.1_Missense_Mutation_p.R173H	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	173					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TAGGACAGTACGGCTCCGTCT	0.577000													22	54					0	0	0.091800	0	0
KCND2	3751	broad.mit.edu	37	7	120373105	120373105	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:120373105C>A	ENST00000331113.4	+	2	2229	c.1264C>A	c.(1264-1266)Cga>Aga	p.R422R		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	422					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					AGCAGACAAACGAAGGGCACA	0.438000													117	170					2.10578e-59	3.49861e-59	0.048971	1	0
UNC79	57578	broad.mit.edu	37	14	94089145	94089145	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:94089145T>C	ENST00000553484.1	+	31	5786	c.5632T>C	c.(5632-5634)Tcc>Ccc	p.S1878P	UNC79_ENST00000393151.2_Missense_Mutation_p.S1856P|UNC79_ENST00000555664.1_Missense_Mutation_p.S1856P|UNC79_ENST00000256339.4_Missense_Mutation_p.S1679P			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1856						integral to membrane		p.S1679T(1)|p.S1878T(1)		breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCTCGACATCTCCTTCAACAT	0.453000													16	143					0	0	0.033300	0	0
TRAV26-1	28657	broad.mit.edu	37	14	22591467	22591467	+	RNA	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:22591467C>A	ENST00000390455.3	+	0	192																											GTCCACAATCCTCATTTGTCC	0.448000													34	43					3.33393e-15	4.59191e-15	0.074837	1	0
CLEC7A	64581	broad.mit.edu	37	12	10280406	10280406	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:10280406C>G	ENST00000353231.5	-	2	300	c.142G>C	c.(142-144)Gta>Cta	p.V48L	CLEC7A_ENST00000310002.4_Missense_Mutation_p.V48L|CLEC7A_ENST00000304084.8_Missense_Mutation_p.V48L|CLEC7A_ENST00000533022.1_Missense_Mutation_p.V48L|CLEC7A_ENST00000396484.2_Intron|CLEC7A_ENST00000525605.1_Missense_Mutation_p.V48L|CLEC7A_ENST00000298523.5_Missense_Mutation_p.V48L	NM_022570.4	NP_072092.2	Q9BXN2	CLC7A_HUMAN	C-type lectin domain family 7, member A	48					carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding	p.V48I(3)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						CCCAAAATTACAGCAATGAGG	0.483000													7	6					0	0	0.038147	0	0
CCDC13	152206	broad.mit.edu	37	3	42784550	42784550	+	Splice_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:42784550C>A	ENST00000310232.6	-	8	909		c.e8-1		CCDC13-AS1_ENST00000418161.1_RNA|CCDC13-AS1_ENST00000446950.1_RNA	NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13											endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						GCTCTTGAACCTGAGGATGGT	0.537000													6	56					5.18039e-06	5.96994e-06	0.038147	1	0
LRP1B	53353	broad.mit.edu	37	2	141812825	141812825	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:141812825C>A	ENST00000389484.3	-	10	2383	c.1412G>T	c.(1411-1413)aGa>aTa	p.R471I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	471					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGCATGGCTTCTGACTACAAC	0.408000										TSP Lung(27;0.18)			43	74					5.52606e-06	6.33872e-06	0.048971	1	0
SLC38A6	145389	broad.mit.edu	37	14	61482646	61482646	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:61482646G>T	ENST00000354886.2	+	4	499	c.335G>T	c.(334-336)gGa>gTa	p.G112V	SLC38A6_ENST00000456840.2_Missense_Mutation_p.G89V|SLC38A6_ENST00000267488.4_Missense_Mutation_p.G112V	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	112					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		GAAGATCTTGGACTCTTTGCA	0.353000													16	70					0.00121646	0.00131208	0.049695	1	0
TOR3A	64222	broad.mit.edu	37	1	179064318	179064318	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:179064318T>A	ENST00000367627.3	+	6	1911	c.1159T>A	c.(1159-1161)Tct>Act	p.S387T	TOR3A_ENST00000352445.6_Intron	NM_022371.3	NP_071766.2	Q9H497	TOR3A_HUMAN	torsin family 3, member A	387					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|urinary_tract(1)	13						GGGCTGCAAGTCTATTTCCCA	0.488000													55	287					0	0	0.048971	0	0
ARSF	416	broad.mit.edu	37	X	2990216	2990216	+	Splice_Site	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:2990216G>A	ENST00000381127.1	+	3	382	c.161_splice	c.e3+1	p.R54_splice	ARSF_ENST00000537104.1_Splice_Site_p.R54_splice|ARSF_ENST00000359361.2_Splice_Site_p.R54_splice	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	54						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GACACCATGAGGTAAGGCGGT	0.498000													40	58					0	0	0.042209	0	0
HRH2	3274	broad.mit.edu	37	5	175110088	175110088	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:175110088C>A	ENST00000231683.2	+	0	1625				HRH2_ENST00000377291.2_De_novo_Start_OutOfFrame	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2						G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	TTCCCCACCCCCTGGCCaaaa	0.418000													3	13					0.00198382	0.00211817	0.029380	1	0
LOC100130331	100130331	broad.mit.edu	37	1	238090281	238090281	+	RNA	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:238090281G>T	ENST00000450451.1	+	0	1787					NR_027247.2																						GGGCCAGAAGGACTCCTACGT	0.602000													17	42					3.32936e-07	3.95361e-07	0.038395	1	0
DIO2	1734	broad.mit.edu	37	14	80677673	80677673	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:80677673C>T	ENST00000557010.1	-	3	528	c.143G>A	c.(142-144)cGc>cAc	p.R48H	DIO2_ENST00000555750.1_Missense_Mutation_p.R48H|DIO2_ENST00000557125.1_Intron|DIO2_ENST00000438257.4_Missense_Mutation_p.R48H|DIO2_ENST00000422005.3_Missense_Mutation_p.R48H	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	48					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCACTCTCCGCGAGTGGACTT	0.582000													14	19					0	0	0.099896	0	0
PXDNL	137902	broad.mit.edu	37	8	52321170	52321170	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:52321170A>T	ENST00000356297.4	-	17	3114	c.3014T>A	c.(3013-3015)gTg>gAg	p.V1005E	PXDNL_ENST00000543296.1_Missense_Mutation_p.V1005E	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1005					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTCCGCGCCCACGATCTTCCT	0.627000													10	5					0	0	0.069234	0	0
MYO18B	84700	broad.mit.edu	37	22	26181403	26181403	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:26181403T>A	ENST00000335473.7	+	11	2571	c.2321T>A	c.(2320-2322)cTg>cAg	p.L774Q	MYO18B_ENST00000536101.1_Missense_Mutation_p.L774Q|MYO18B_ENST00000407587.2_Missense_Mutation_p.L774Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	774	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGGACGGAGCTGAACCTGCAC	0.612000													24	38					0	0	0.099896	0	0
SEMA6B	10501	broad.mit.edu	37	19	4556051	4556051	+	Silent	SNP	C	C	A	rs73527729	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:4556051C>A	ENST00000586582.1	-	6	730	c.420G>T	c.(418-420)acG>acT	p.T140T	SEMA6B_ENST00000301293.3_Silent_p.T140T|SEMA6B_ENST00000586965.1_Silent_p.T140T	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	140	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACAAAGAGCGTGGACTCGT	0.627000													18	9					2.37509e-13	3.14838e-13	0.055883	1	0
PIEZO2	63895	broad.mit.edu	37	18	10675214	10675214	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:10675214A>G	ENST00000302079.6	-	49	7624	c.7625T>C	c.(7624-7626)cTt>cCt	p.L2542P	PIEZO2_ENST00000503781.3_Missense_Mutation_p.L2605P|PIEZO2_ENST00000285141.4_Missense_Mutation_p.L397P|PIEZO2_ENST00000538948.1_Missense_Mutation_p.L562P|PIEZO2_ENST00000580640.1_Missense_Mutation_p.L2630P|PIEZO2_ENST00000581680.1_5'UTR			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2605						integral to membrane	ion channel activity										ACCAGATAAAAGTTGCTTTAT	0.294000													20	31					0	0	0.069288	0	0
GPR112	139378	broad.mit.edu	37	X	135427340	135427340	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:135427340C>A	ENST00000394143.1	+	6	1766	c.1475C>A	c.(1474-1476)cCa>cAa	p.P492Q	GPR112_ENST00000412101.1_Missense_Mutation_p.P287Q|GPR112_ENST00000370652.1_Missense_Mutation_p.P492Q|GPR112_ENST00000287534.4_Missense_Mutation_p.P429Q|GPR112_ENST00000394141.1_Missense_Mutation_p.P287Q	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	492					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACAGCATTTCCATTGGCAACA	0.458000													19	649					1.33834e-09	1.67802e-09	0.043863	1	0
FGFR4	2264	broad.mit.edu	37	5	176522357	176522357	+	Missense_Mutation	SNP	G	G	A	rs34158682		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:176522357G>A	ENST00000292408.4	+	12	1791	c.1546G>A	c.(1546-1548)Gac>Aac	p.D516N	FGFR4_ENST00000292410.3_Missense_Mutation_p.D476N|FGFR4_ENST00000393637.1_Missense_Mutation_p.D476N|FGFR4_ENST00000393648.2_Missense_Mutation_p.D448N|FGFR4_ENST00000502906.1_Missense_Mutation_p.D516N	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	516	Protein kinase.		D -> N (in dbSNP:rs34158682).		insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GGACCTGGCCGACCTGGTCTC	0.617000										TSP Lung(9;0.080)			19	48					0	0	0.062417	0	0
GPR156	165829	broad.mit.edu	37	3	119905559	119905559	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:119905559C>A	ENST00000464295.1	-	6	991	c.546G>T	c.(544-546)acG>acT	p.T182T	GPR156_ENST00000461057.1_Silent_p.T182T|GPR156_ENST00000315843.3_Silent_p.T182T			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	182						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TCAGCACCCACGTCATGAGCA	0.512000													25	111					3.17567e-06	3.67683e-06	0.037714	1	0
ST3GAL2	6483	broad.mit.edu	37	16	70432294	70432294	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:70432294C>A	ENST00000393640.4	-	1	2247	c.140G>T	c.(139-141)cGg>cTg	p.R47L	ST3GAL2_ENST00000342907.2_Missense_Mutation_p.R47L|RP11-529K1.4_ENST00000566960.1_RNA			Q16842	SIA4B_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	47					amino sugar metabolic process	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	11		Ovarian(137;0.0694)				CAGCTTCACCCGGTGCGTCCC	0.657000													6	6					8.12818e-05	9.07076e-05	0.029380	1	0
OVCH1	341350	broad.mit.edu	37	12	29617494	29617494	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:29617494G>T	ENST00000318184.5	-	18	2070	c.2071C>A	c.(2071-2073)Cct>Act	p.P691T	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	691	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GAAAATAGAGGCTCTGCGCTG	0.458000													25	19					5.45024e-15	7.45134e-15	0.083992	1	0
WDR19	57728	broad.mit.edu	37	4	39276448	39276448	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:39276448T>A	ENST00000399820.3	+	33	3740	c.3586T>A	c.(3586-3588)Tca>Aca	p.S1196T	WDR19_ENST00000288634.7_Missense_Mutation_p.S1036T	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1196					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CATCCTGACGTCAACTGTGAT	0.512000													32	151					0	0	0.069456	0	0
KRTAP24-1	643803	broad.mit.edu	37	21	31654512	31654512	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:31654512C>A	ENST00000340345.4	-	1	764	c.739G>T	c.(739-741)Ggt>Tgt	p.G247C		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	247	6 X 10 AA repeats of Y-[ILR]-[SVPC]- [NRTS]-[SNTG]-X-[QHRP]-[PSY]-[QSL]-[SRK].					keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						GGTCTGCTACCACTGCACAAA	0.443000													49	92					4.1673e-28	6.44671e-28	0.048971	1	0
PCDHGB4	8641	broad.mit.edu	37	5	140769092	140769092	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:140769092C>T	ENST00000519479.1	+	1	1641	c.1641C>T	c.(1639-1641)cgC>cgT	p.R547R	PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCCTGCGCGTGTTAGTGG	0.692000													4	15					0	0	0.009096	0	0
NRIP1	8204	broad.mit.edu	37	21	16340221	16340221	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:16340221C>T	ENST00000400202.1	-	3	1005	c.293G>A	c.(292-294)cGg>cAg	p.R98Q	NRIP1_ENST00000318948.4_Missense_Mutation_p.R98Q|NRIP1_ENST00000400199.1_Missense_Mutation_p.R98Q			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	98	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CAGCCTCTTCCGCTTTGCTGC	0.463000													14	54					0	0	0.020292	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768669	31768669	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:31768669C>A	ENST00000240587.4	-	2	2357	c.2030G>T	c.(2029-2031)gGg>gTg	p.G677V		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	677					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G677V(1)|p.G494V(1)		breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					ATCCTTGCACCCATCCCGCGG	0.647000													25	36					7.26314e-15	9.91158e-15	0.034045	1	0
RAB6B	51560	broad.mit.edu	37	3	133547660	133547660	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:133547660G>T	ENST00000285208.4	-	8	948	c.599C>A	c.(598-600)cCg>cAg	p.P200Q	RAB6B_ENST00000543906.1_Missense_Mutation_p.P200Q|RAB6B_ENST00000469959.1_Intron|RAB6B_ENST00000486858.1_Missense_Mutation_p.P187Q	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	200					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						CTCGCTGGCCGGGGGCTCCTG	0.587000													30	92					6.29468e-14	8.46527e-14	0.074837	1	0
PCDH11X	27328	broad.mit.edu	37	X	91090515	91090515	+	Missense_Mutation	SNP	G	G	T	rs144734965	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:91090515G>T	ENST00000373094.1	+	1	857	c.12G>T	c.(10-12)ttG>ttT	p.L4F	PCDH11X_ENST00000395337.2_Missense_Mutation_p.L4F|PCDH11X_ENST00000406881.1_Missense_Mutation_p.L4F|PCDH11X_ENST00000373097.1_Missense_Mutation_p.L4F|PCDH11X_ENST00000361724.1_Missense_Mutation_p.L4F|PCDH11X_ENST00000373088.1_Missense_Mutation_p.L4F|PCDH11X_ENST00000361655.2_Missense_Mutation_p.L4F|PCDH11X_ENST00000298274.8_Missense_Mutation_p.L4F|PCDH11X_ENST00000504220.1_Missense_Mutation_p.L4F	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	4					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGGACTTGTTGTCCGGGACGT	0.468000													32	45					9.65021e-13	1.26563e-12	0.045705	1	0
CLVS2	134829	broad.mit.edu	37	6	123369765	123369765	+	Splice_Site	SNP	A	A	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:123369765A>T	ENST00000275162.4	+	4	1899		c.e4-1		CLVS2_ENST00000368438.1_Splice_Site	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2						lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						ATGTTACTCTAGGATAGTTTC	0.368000													50	50					0	0	0.048971	0	0
CACNG4	27092	broad.mit.edu	37	17	65028026	65028026	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:65028026C>A	ENST00000375684.1	+	2	479	c.479C>A	c.(478-480)aCt>aAt	p.T160N	CACNG4_ENST00000262138.3_3'UTR																							CTCCCTCCAACTGGCATTTGG	0.552000													4	4					0.00116845	0.00126213	0.021553	1	0
BRWD3	254065	broad.mit.edu	37	X	79936893	79936893	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:79936893T>C	ENST00000373275.4	-	40	4817	c.4601A>G	c.(4600-4602)cAt>cGt	p.H1534R	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1534										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CCCTGGGTCATGGCTATTTCC	0.398000													116	193					0	0	0.048971	0	0
ZBTB3	79842	broad.mit.edu	37	11	62519825	62519825	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:62519825G>T	ENST00000394807.3	-	2	1587	c.1462C>A	c.(1462-1464)Cgg>Agg	p.R488R		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						GCATGTCGCCGTAGTGTGTAA	0.562000													6	41					8.12818e-05	9.07076e-05	0.029380	1	0
TRAK2	66008	broad.mit.edu	37	2	202254176	202254176	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:202254176C>G	ENST00000332624.3	-	12	1672	c.1244G>C	c.(1243-1245)cGg>cCg	p.R415P		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	415	Interaction with HGS (By similarity).			Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						AGAGCGGCCCCGTGTGTCATT	0.473000													14	49					0	0	0.020292	0	0
SALL1	6299	broad.mit.edu	37	16	51172874	51172874	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:51172874T>C	ENST00000440970.1	-	2	3399	c.2968A>G	c.(2968-2970)Aca>Gca	p.T990A	SALL1_ENST00000251020.4_Missense_Mutation_p.T1087A|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1087					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TTGACCTCTGTCTTGATGAGA	0.572000													17	32					0	0	0.055883	0	0
DBH	1621	broad.mit.edu	37	9	136501612	136501612	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:136501612C>A	ENST00000393056.2	+	1	131	c.119C>A	c.(118-120)tCg>tAg	p.S40*		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	40					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CTGCAGGGCTCGGCTCCCCGT	0.662000													8	8					0.000274275	0.000301988	0.047766	1	0
KIAA1429	25962	broad.mit.edu	37	8	95523891	95523891	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:95523891G>A	ENST00000297591.5	-	13	2987	c.2912C>T	c.(2911-2913)aCg>aTg	p.T971M	KIAA1429_ENST00000421249.2_Missense_Mutation_p.T971M|KIAA1429_ENST00000437199.1_Missense_Mutation_p.T971M	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	971					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCGAATAAACGTGTCCATTCC	0.378000													14	140					0	0	0.028581	0	0
COL5A2	1290	broad.mit.edu	37	2	189957113	189957113	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:189957113G>T	ENST00000374866.3	-	7	764	c.490C>A	c.(490-492)Cca>Aca	p.P164T		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	164					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGAACACCTGGTTCTCCATCA	0.512000													10	23					0.010729	0.0111817	0.080935	1	0
RMDN1	51115	broad.mit.edu	37	8	87498840	87498840	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:87498840C>G	ENST00000406452.3	-	4	527	c.368G>C	c.(367-369)cGg>cCg	p.R123P	CPNE3_ENST00000198765.4_Intron|RMDN1_ENST00000519966.1_Missense_Mutation_p.R123P|RMDN1_ENST00000430676.2_Missense_Mutation_p.R123P|RMDN1_ENST00000523911.1_Missense_Mutation_p.R79P	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1									p.R123L(1)									ACGTGATGCCCGTGCCAAACG	0.373000													6	58					0	0	0.021553	0	0
POTEE	445582	broad.mit.edu	37	2	132021524	132021524	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:132021524G>T	ENST00000356920.5	+	15	2590	c.2496G>T	c.(2494-2496)atG>atT	p.M832I	PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	832	Actin-like.						ATP binding										CCCCAGCCATGTACGTGGCCA	0.612000													40	94					6.81593e-30	1.06329e-29	0.048971	1	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	2					0	0	0.009096	0	0
PLA2G7	7941	broad.mit.edu	37	6	46675888	46675888	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:46675888C>A	ENST00000274793.7	-	10	1076	c.880G>T	c.(880-882)Gcc>Tcc	p.A294S	PLA2G7_ENST00000537365.1_Missense_Mutation_p.A294S	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	294					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			GCATCCAGGGCAATACCACAT	0.383000													19	127					8.04996e-18	1.14933e-17	0.062417	1	0
MT-CO2	4513	broad.mit.edu	37	MT	7616	7616	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrM:7616G>A	ENST00000361739.1	+	1	31	c.31G>A	c.(31-33)Gac>Aac	p.D11N						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						TAGGTCTACAAGACGCTACTT	0.373000													6	413					0	0	0.038147	0	0
CLMP	79827	broad.mit.edu	37	11	122944291	122944291	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:122944291G>T	ENST00000448775.2	-	7	1353	c.1013C>A	c.(1012-1014)cCa>cAa	p.P338Q	CLMP_ENST00000530371.1_5'UTR	NM_024769.2	NP_079045.1	Q9H6B4	CLMP_HUMAN	CXADR-like membrane protein	338						integral to membrane|tight junction				endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	14						TCTCACCTCTGGCCCCACTAG	0.582000													8	59					5.18039e-06	5.96994e-06	0.038147	1	0
PLCB1	23236	broad.mit.edu	37	20	8637933	8637933	+	Splice_Site	SNP	T	T	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:8637933T>C	ENST00000378641.3	+	8	1170		c.e8+2		PLCB1_ENST00000338037.6_Splice_Site|PLCB1_ENST00000378637.2_Splice_Site	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TTCAGAATTGTAAGAGTACAC	0.388000													9	56					0	0	0.058154	0	0
POT1	25913	broad.mit.edu	37	7	124464083	124464083	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:124464083G>C	ENST00000357628.3	-	19	2436	c.1838C>G	c.(1837-1839)aCa>aGa	p.T613R	POT1_ENST00000393329.1_Missense_Mutation_p.T482R	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	613					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						TGTTCCATTTGTGACATTGTA	0.299000													9	22					0	0	0.080935	0	0
COL7A1	1294	broad.mit.edu	37	3	48621469	48621469	+	Splice_Site	SNP	C	C	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:48621469C>G	ENST00000328333.8	-	37	4330	c.4224_splice	c.e37+1	p.R1408_splice	COL7A1_ENST00000454817.1_Splice_Site_p.R1408_splice	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1408	Interrupted collagenous region.|Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCACTTACCCGCTCCCCACG	0.577000													4	23					0	0	0.014758	0	0
GARNL3	84253	broad.mit.edu	37	9	130116205	130116205	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:130116205G>T	ENST00000373387.4	+	18	1976	c.1624G>T	c.(1624-1626)Gtt>Ttt	p.V542F	GARNL3_ENST00000435213.2_Missense_Mutation_p.V520F|GARNL3_ENST00000314904.5_Missense_Mutation_p.V542F	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	542	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						GGACCTTCTGGTTCTCAGAGC	0.547000													13	42					2.32078e-09	2.89025e-09	0.024245	1	0
ZC3H14	79882	broad.mit.edu	37	14	89041146	89041146	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:89041146G>T	ENST00000251038.5	+	7	1196	c.971G>T	c.(970-972)cGa>cTa	p.R324L	ZC3H14_ENST00000302216.8_Missense_Mutation_p.R324L|ZC3H14_ENST00000336693.4_Missense_Mutation_p.R290L|ZC3H14_ENST00000555755.1_Missense_Mutation_p.R324L|ZC3H14_ENST00000393514.5_Missense_Mutation_p.R324L|ZC3H14_ENST00000557607.1_Missense_Mutation_p.R169L|ZC3H14_ENST00000556945.1_Missense_Mutation_p.R324L|ZC3H14_ENST00000359301.3_Missense_Mutation_p.R290L|ZC3H14_ENST00000557605.1_3'UTR	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	324						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding	p.R324Q(1)		cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						TACGGGTCTCGAACAGGAAGC	0.428000													23	29					1.10923e-09	1.39786e-09	0.076483	1	0
FRMPD3	84443	broad.mit.edu	37	X	106808261	106808261	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:106808261G>A	ENST00000276185.4	+	13	1360	c.1360G>A	c.(1360-1362)Gtg>Atg	p.V454M				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	454	FERM.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GAACCAGGGCGTGGCCCGGGT	0.537000													7	71					0	0	0.029380	0	0
IFLTD1	160492	broad.mit.edu	37	12	25672901	25672901	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:25672901C>A	ENST00000539744.1	-	7	1032	c.553G>T	c.(553-555)Gtg>Ttg	p.V185L	IFLTD1_ENST00000445693.1_Missense_Mutation_p.V219L|IFLTD1_ENST00000282881.6_Missense_Mutation_p.V282L|IFLTD1_ENST00000458174.2_Missense_Mutation_p.V303L|IFLTD1_ENST00000413632.2_Missense_Mutation_p.V263L	NM_001256266.1	NP_001243195.1	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	282						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					CACTGAAACACACGCTTTCGG	0.398000													32	35					9.65021e-13	1.26563e-12	0.045705	1	0
GPR174	84636	broad.mit.edu	37	X	78426599	78426599	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:78426599C>T	ENST00000276077.1	+	1	131	c.95C>T	c.(94-96)cCa>cTa	p.P32L		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	32						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						ATTCTTGTGCCAGGTCTCATA	0.383000										HNSCC(63;0.18)			27	35					0	0	0.099896	0	0
ZNF862	643641	broad.mit.edu	37	7	149559371	149559371	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:149559371G>A	ENST00000223210.4	+	7	3367	c.3122G>A	c.(3121-3123)cGg>cAg	p.R1041Q		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	1041					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						TGCTGTGAGCGGGGGTTCAAG	0.597000													4	18					0	0	0.009096	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47122408	47122408	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:47122408C>T	ENST00000290341.3	+	12	1710	c.1376C>T	c.(1375-1377)cCg>cTg	p.P459L	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.P320L	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	459	KH 3.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						ATCACTGGACCGCCAGAGGCC	0.463000													21	141					0	0	0.091800	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025350	176025350	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:176025350C>T	ENST00000303991.4	-	2	1663	c.1486G>A	c.(1486-1488)Gat>Aat	p.D496N		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	496						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GACCTGGGATCGCCTGGACCT	0.547000													10	22					0	0	0.069234	0	0
GIF	2694	broad.mit.edu	37	11	59609961	59609961	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:59609961G>C	ENST00000541311.1	-	4	625	c.391C>G	c.(391-393)Cgc>Ggc	p.R131G	GIF_ENST00000257248.2_Missense_Mutation_p.R156G			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	156					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						TTGGCAAAGCGGACGGCTATC	0.577000													32	114					0	0	0.069456	0	0
ZNF429	353088	broad.mit.edu	37	19	21720466	21720466	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:21720466C>A	ENST00000358491.4	+	4	1819	c.1611C>A	c.(1609-1611)taC>taA	p.Y537*	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	537					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						AGAAACCTTACAAATGTGAAG	0.373000													4	26					0.00024832	0.000274635	0.009096	1	0
CTNNA3	29119	broad.mit.edu	37	10	69281660	69281660	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:69281660G>A	ENST00000433211.1	-	5	693	c.519C>T	c.(517-519)acC>acT	p.T173T	CTNNA3_ENST00000373744.4_Silent_p.T173T|CTNNA3_ENST00000545309.1_Silent_p.T173T	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	173					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						GCTTCTGGTAGGTTTTCTGGA	0.418000													7	71					0	0	0.029380	0	0
AASS	10157	broad.mit.edu	37	7	121733185	121733185	+	Silent	SNP	A	A	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:121733185A>C	ENST00000393376.1	-	15	1778	c.1683T>G	c.(1681-1683)ctT>ctG	p.L561L	AASS_ENST00000417368.2_Silent_p.L561L|AASS_ENST00000473553.1_5'UTR			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	561	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCTTGGCCACAAGAGGGTGCA	0.378000													48	93					0	0	0.048971	0	0
KIAA1429	25962	broad.mit.edu	37	8	95541452	95541452	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:95541452C>A	ENST00000297591.5	-	7	801	c.726G>T	c.(724-726)gaG>gaT	p.E242D	KIAA1429_ENST00000421249.2_Missense_Mutation_p.E242D|KIAA1429_ENST00000437199.1_Missense_Mutation_p.E242D	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	242	Glu-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			cttgttgttcctcttctactt	0.438000													32	26					1.30897e-18	1.88339e-18	0.041601	1	0
NPLOC4	55666	broad.mit.edu	37	17	79580490	79580490	+	Silent	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:79580490C>A	ENST00000374747.5	-	4	369	c.240G>T	c.(238-240)tcG>tcT	p.S80S	NPLOC4_ENST00000539314.1_5'UTR|NPLOC4_ENST00000574344.1_5'UTR|NPLOC4_ENST00000331134.6_Silent_p.S80S			Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	80					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CAGCAAGGCTCGAGGGAAACA	0.517000													12	23					0.00136819	0.00147145	0.093190	1	0
PFKFB1	5207	broad.mit.edu	37	X	54987335	54987335	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:54987335T>A	ENST00000375006.3	-	3	309	c.239A>T	c.(238-240)cAg>cTg	p.Q80L	PFKFB1_ENST00000545676.1_Missense_Mutation_p.Q15L|PFKFB1_ENST00000374992.2_Intron	NM_002625.2	NP_002616.2	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	80	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)	24						TCGTCGATACTGGCCTAAATT	0.463000													14	67					0	0	0.028581	0	0
CNGB3	54714	broad.mit.edu	37	8	87755832	87755832	+	Silent	SNP	G	G	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:87755832G>T	ENST00000320005.5	-	1	71	c.24C>A	c.(22-24)gtC>gtA	p.V8V	RP11-386D6.1_ENST00000519041.1_RNA|CNGB3_ENST00000519777.1_5'UTR	NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	8					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TCACCTTGTTGACTTTTGTCA	0.408000													22	108					9.57634e-11	1.22346e-10	0.083992	1	0
IQGAP2	10788	broad.mit.edu	37	5	75954465	75954465	+	Silent	SNP	G	G	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:75954465G>A	ENST00000274364.6	+	21	2799	c.2502G>A	c.(2500-2502)ctG>ctA	p.L834L	IQGAP2_ENST00000396234.3_Silent_p.L330L|IQGAP2_ENST00000502745.1_Silent_p.L330L|IQGAP2_ENST00000379730.3_Silent_p.L336L	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	834					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGATTGGACTGCTGGTGAAGA	0.473000													58	39					0	0	0.048971	0	0
HTR5A	3361	broad.mit.edu	37	7	154863018	154863018	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:154863018C>A	ENST00000287907.2	+	1	985	c.409C>A	c.(409-411)Ctg>Atg	p.L137M	AC093726.4_ENST00000493904.1_5'UTR|AC093726.4_ENST00000395731.2_De_novo_Start_InFrame|AC093726.4_ENST00000543018.1_De_novo_Start_InFrame	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	137						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GGCCATAGCCCTGGACCGCTA	0.652000													18	15					7.45023e-12	9.68529e-12	0.055883	1	0
MKI67	4288	broad.mit.edu	37	10	129903161	129903161	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:129903161C>A	ENST00000368654.3	-	13	7318	c.6943G>T	c.(6943-6945)Gac>Tac	p.D2315Y	MKI67_ENST00000368653.3_Missense_Mutation_p.D1955Y	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2315	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCAGCCAGGTCTTCTAGAGCC	0.488000													42	142					1.62957e-23	2.43942e-23	0.104719	1	0
EPB41L1	2036	broad.mit.edu	37	20	34778240	34778240	+	Silent	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:34778240C>T	ENST00000338074.2	+	10	1229	c.1068C>T	c.(1066-1068)aaC>aaT	p.N356N	EPB41L1_ENST00000373941.1_Silent_p.N356N|EPB41L1_ENST00000373946.3_Silent_p.N325N|EPB41L1_ENST00000441639.1_Silent_p.N294N|EPB41L1_ENST00000373950.2_Silent_p.N259N|EPB41L1_ENST00000202028.5_Silent_p.N294N	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	356	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGCTCCCAAACCACCGGTCAG	0.547000													13	50					0	0	0.028581	0	0
KIZ-AS1	101929591	broad.mit.edu	37	20	21142700	21142700	+	RNA	SNP	C	C	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:21142700C>T	ENST00000591761.1	-	0	5142				RP5-872K7.7_ENST00000425746.2_RNA|PLK1S1_ENST00000457464.1_RNA																							GACAGACAGCCCAGAGCAGTA	0.438000													42	53					0	0	0.111260	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47243516	47243516	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:47243516C>A	ENST00000300404.2	+	9	1234	c.1175C>A	c.(1174-1176)aCc>aAc	p.T392N	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.T306N|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.T332N	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	392					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TCTCAGGTCACCACCAAATAC	0.473000													11	17					1.58986e-06	1.86112e-06	0.069234	1	0
RP5-1180C18.1	0	broad.mit.edu	37	1	37753994	37754023	+	RNA	DEL	GGACTTCATTCTGTAGACTCTCAGGGGCCC	GGACTTCATTCTGTAGACTCTCAGGGGCCC	-	rs66759422		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:37753994_37754023delGGACTTCATTCTGTAGACTCTCAGGGGCCC	ENST00000413901.1	-	0	111																											TCAGGGGCTTGGACTTCATTCTGTAGACTCTCAGGGGCCCGGACTTCATT	0.526													3	4	---	---	---	---					
RP5-884C9.2	0	broad.mit.edu	37	1	38525080	38525081	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:38525080_38525081insG	ENST00000432922.1	+	0	301																											cctggaggaatgggggtggagc	0.505													2	4	---	---	---	---					
TAL1	6886	broad.mit.edu	37	1	47691474	47691475	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:47691474_47691475insG	ENST00000371883.3	-	2	662_663	c.86_87insC	c.(85-87)ccafs	p.P29fs	TAL1_ENST00000294339.3_Frame_Shift_Ins_p.P29fs|TAL1_ENST00000371884.2_Frame_Shift_Ins_p.P29fs|RP1-18D14.7_ENST00000422216.1_RNA			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	29					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						GGACCAGGTGCGGGGGGGCCAT	0.762			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								2	4	---	---	---	---					
RP11-378I13.1	0	broad.mit.edu	37	1	57291864	57291864	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:57291864delG	ENST00000425435.1	-	0	356																											TCCCCTCTATGGGGGGTTGTA	0.483													2	4	---	---	---	---					
JAK1	3716	broad.mit.edu	37	1	65303784	65303784	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:65303784delT	ENST00000342505.4	-	22	3219	c.2971delA	c.(2971-2973)tgfs	p.M991fs		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	991	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		AAATAGTCCATCCCCTGAGAG	0.393			Mis		ALL								7	16	---	---	---	---					
LOC100129620	100129620	broad.mit.edu	37	1	99553646	99553646	+	RNA	DEL	A	A	-	rs78048414		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:99553646delA	ENST00000425113.1	+	0	370					NR_033940.1																						agagaaaaggaaaaaaaaagt	0.353													5	2	---	---	---	---					
RP5-936J12.1	0	broad.mit.edu	37	1	103280765	103280765	+	RNA	DEL	A	A	-	rs68159862	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:103280765delA	ENST00000414418.1	-	0	251																											attttattttatttttttaca	0.343													3	3	---	---	---	---					
LAMTOR5-AS1	101410535	broad.mit.edu	37	1	110962613	110962613	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:110962613delG	ENST00000585433.2	+	0	182				LAMTOR5-AS1_ENST00000444238.2_RNA|LAMTOR5-AS1_ENST00000599202.1_RNA|LAMTOR5-AS1_ENST00000598350.1_RNA|LAMTOR5-AS1_ENST00000596890.1_RNA|LAMTOR5-AS1_ENST00000598158.1_RNA																							CCACAGCTGAGGGGCTGGAAT	0.602													2	4	---	---	---	---					
RP5-965F6.2	0	broad.mit.edu	37	1	112851315	112851315	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:112851315delG	ENST00000427290.1	-	0	167																											ATTGATTCAAGGGGAAAGACA	0.448													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142623788	142623788	+	RNA	DEL	T	T	-	rs149122083		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:142623788delT	ENST00000369381.2	-	0	5218				RP11-417J8.3_ENST00000426408.1_lincRNA																							TGGGTTCTGGTTTTAGCACGT	0.438													3	4	---	---	---	---					
RP11-423O2.7	0	broad.mit.edu	37	1	142951514	142951514	+	RNA	DEL	C	C	-	rs143173818		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:142951514delC	ENST00000424640.2	-	0	284																											GGTTGTACTGCTGGGCTTAAG	0.453													3	5	---	---	---	---					
SEC22B	9554	broad.mit.edu	37	1	145116299	145116300	+	RNA	INS	-	-	TT	rs36214234		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:145116299_145116300insTT	ENST00000453618.1	+	0	1385_1386							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TTGGGAAGGTGttttttttttt	0.332													6	11	---	---	---	---					
NBPF12	149013	broad.mit.edu	37	1	146418202	146418202	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:146418202delC	ENST00000442909.2	+	21	3351	c.2515delC	c.(2515-2517)tcfs	p.L839fs	NBPF12_ENST00000309471.8_Frame_Shift_Del_p.L493fs|NBPF12_ENST00000446760.2_Frame_Shift_Del_p.L567fs					neuroblastoma breakpoint family, member 12											ovary(2)	2						TTATTCGACTCTCTCAATTCC	0.498													16	28	---	---	---	---					
RP11-495P10.2	0	broad.mit.edu	37	1	147852710	147852711	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:147852710_147852711insA	ENST00000381475.3	-	0	210																											ttgtccaccgctccccgacttc	0.386													3	3	---	---	---	---					
RNVU1-18	26863	broad.mit.edu	37	1	149224056	149224057	+	RNA	INS	-	-	G	rs67440455		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:149224056_149224057insG	ENST00000384010.1	-	0	164					NR_004400.1|NR_004402.2|NR_004408.1|NR_004421.1|NR_004424.2|NR_004427.1|NR_004430.2																						ACTACAAAAAATcaggggaaag	0.446													4	5	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152169856	152169859	+	RNA	DEL	TCTT	TCTT	-	rs138883689		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152169856_152169859delTCTT	ENST00000420707.1	+	0	158				FLG-AS1_ENST00000593011.1_RNA																							ctctttcctctctttctttcttct	0.431													4	8	---	---	---	---					
RP1-91G5.3	0	broad.mit.edu	37	1	152390764	152390765	+	RNA	DEL	CA	CA	-	rs67541680	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:152390764_152390765delCA	ENST00000411804.1	+	0	94																											CGCGCGCGCGcacacacacaca	0.550													3	5	---	---	---	---					
TPM3	7170	broad.mit.edu	37	1	154148630	154148630	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:154148630delT	ENST00000368533.3	-	2	279	c.227delA	c.(226-228)agfs	p.K76fs	TPM3_ENST00000368530.2_Frame_Shift_Del_p.K113fs|TPM3_ENST00000328159.4_Frame_Shift_Del_p.K76fs|TPM3_ENST00000469717.1_Intron|TPM3_ENST00000302206.5_5'UTR|TPM3_ENST00000341485.5_Frame_Shift_Del_p.K76fs|TPM3_ENST00000341372.3_Frame_Shift_Del_p.K51fs|TPM3_ENST00000330188.9_Frame_Shift_Del_p.K76fs|TPM3_ENST00000271850.7_Frame_Shift_Del_p.K113fs|TPM3_ENST00000368531.2_Frame_Shift_Del_p.K76fs|TPM3_ENST00000323144.7_Frame_Shift_Del_p.K76fs	NM_001043352.1|NM_001278188.1|NM_153649.3	NP_001036817.1|NP_001265117.1|NP_705935.1	P06753	TPM3_HUMAN	tropomyosin 3	112					cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/NTRK1_ENST00000392302(70)|TPM3/ALK(33)	breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					TTCTTCCAGCTTTTGCAGGGC	0.512			T	"""NTRK1, ALK, ROS1"""	"""papillary thyroid, ALCL, NSCLC"""								112	98	---	---	---	---					
GS1-204I12.4	0	broad.mit.edu	37	1	185625492	185625492	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:185625492delA	ENST00000569292.1	+	0	209																											ctgtaaattgaaaaaaaaaac	0.284													2	4	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187229626	187229626	+	RNA	DEL	T	T	-	rs35570115		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:187229626delT	ENST00000458683.1	+	0	105																											TTGTTTTAAATTTCACTGACT	0.303													7	1	---	---	---	---					
RP11-563D10.1	0	broad.mit.edu	37	1	194149916	194149917	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:194149916_194149917insA	ENST00000454538.1	+	0	384																											tacagaaagggaaaaaaggcag	0.391													2	4	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213905697	213905698	+	RNA	INS	-	-	GTGT	rs113738050	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:213905697_213905698insGTGT	ENST00000456240.1	+	0	143																											tatgagtgtgcgtgtgcgtgtg	0.356													3	6	---	---	---	---					
PROX1-AS1	100505832	broad.mit.edu	37	1	214150769	214150769	+	RNA	DEL	A	A	-	rs11285935		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:214150769delA	ENST00000601744.1	-	0	111				PROX1-AS1_ENST00000601854.1_RNA|PROX1-AS1_ENST00000451396.2_RNA|PROX1-AS1_ENST00000598091.1_RNA																							TCCCTGGGAGAAAAAAAAAAA	0.473													2	4	---	---	---	---					
RP11-261C10.1	0	broad.mit.edu	37	1	243169324	243169326	+	RNA	DEL	AGG	AGG	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr1:243169324_243169326delAGG	ENST00000427176.1	-	0	612_614																											AAAGGTATGAAGGAGAAGATGGA	0.463													5	2	---	---	---	---					
LINC01249	727982	broad.mit.edu	37	2	4684952	4684953	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:4684952_4684953insA	ENST00000412134.1	-	0	328					NR_034134.1																						ggaacttaaacaaatttagaag	0.342													3	3	---	---	---	---					
AC011747.3	0	broad.mit.edu	37	2	8686808	8686808	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:8686808delA	ENST00000418358.1	-	0	136																											GCAGCAGAGCAAAAGAGTCAA	0.527													2	4	---	---	---	---					
AC010969.1	0	broad.mit.edu	37	2	10143928	10143931	+	RNA	DEL	TTCT	TTCT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:10143928_10143931delTTCT	ENST00000340444.1	-	0	1766_1769																											tagcaaatacttctttctccctat	0.451													4	3	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12256557	12256558	+	RNA	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:12256557_12256558insC	ENST00000412294.1	+	0	197																											CTCCACCCCCTCCCCCCTCACT	0.530													3	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12598396	12598397	+	RNA	INS	-	-	T	rs6432294	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:12598396_12598397insT	ENST00000412294.1	+	0	412																											AGCAATAGCAGTTTTTTGGGTG	0.376													2	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12626505	12626505	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:12626505delC	ENST00000412294.1	+	0	412																											TAATTATTCGCCTGCATCCTT	0.488													3	6	---	---	---	---					
LOC100506474	100506474	broad.mit.edu	37	2	13145794	13145797	+	RNA	DEL	CACA	CACA	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:13145794_13145797delCACA	ENST00000425974.1	-	0	143					NR_038434.1																						taacaacaaccacacacacacaca	0.373													6	6	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22486852	22486852	+	RNA	DEL	T	T	-	rs71392881		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:22486852delT	ENST00000450551.1	-	0	70																											gttttgattgttttttttttt	0.333													4	2	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22518438	22518439	+	RNA	INS	-	-	T	rs72019251		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:22518438_22518439insT	ENST00000450551.1	-	0	70																											TTAGGAAGGCCTTTTTTTTTTT	0.391													3	6	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34110020	34110021	+	RNA	DEL	TG	TG	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:34110020_34110021delTG	ENST00000366209.2	+	0	134																											tgtgggtgcctgtgtgtgtgtg	0.465													2	4	---	---	---	---					
AC079807.4	0	broad.mit.edu	37	2	48451730	48451731	+	RNA	INS	-	-	C	rs144936854	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:48451730_48451731insC	ENST00000447571.1	-	0	56																		p.0?(2)									aatagcaataacaggccaggca	0.485													4	3	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51606534	51606534	+	RNA	DEL	A	A	-	rs139703085		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:51606534delA	ENST00000440698.1	+	0	694																											TGAAAGATGCAAAAAAAAAAA	0.313													3	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59760907	59760908	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:59760907_59760908insA	ENST00000606382.1	-	0	236																											CCAATCATAGTAAAAAAACCAG	0.490													2	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60080910	60080910	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:60080910delT	ENST00000606382.1	-	0	110																											TTTTTTTTACTTTTTTTCTGT	0.313													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65808798	65808798	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:65808798delG	ENST00000377977.3	+	0	862																											gcttgagcctgggaggtcgag	0.542													2	4	---	---	---	---					
IGKV1D-43	28891	broad.mit.edu	37	2	90249312	90249312	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:90249312delG	ENST00000468879.1	+	0	449																											CAGTGGATCTGGGACGGATTA	0.473													116	288	---	---	---	---					
AC009404.2	0	broad.mit.edu	37	2	118596655	118596655	+	RNA	DEL	G	G	-	rs35131290		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:118596655delG	ENST00000420330.1	+	0	613																											agaccaacctgggcaacatgg	0.512													3	4	---	---	---	---					
HTR5BP	645694	broad.mit.edu	37	2	118652551	118652551	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:118652551delT	ENST00000434708.1	+	0	113																											tcctttgtcctttttttttta	0.443													2	4	---	---	---	---					
AC062031.1	0	broad.mit.edu	37	2	146683968	146683968	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:146683968delG	ENST00000414967.1	+	0	205																											AATTAAAATAGGGTATTGGAA	0.289													3	4	---	---	---	---					
NEB	4703	broad.mit.edu	37	2	152496381	152496382	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:152496381_152496382insA	ENST00000427231.2	-	62	9080_9081	c.8878_8879insT	c.(8878-8880)tatfs	p.Y2960fs	NEB_ENST00000604864.1_Frame_Shift_Ins_p.Y2960fs|NEB_ENST00000603639.1_Frame_Shift_Ins_p.Y2960fs|NEB_ENST00000172853.10_Frame_Shift_Ins_p.Y2960fs|NEB_ENST00000397345.3_Frame_Shift_Ins_p.Y2960fs|NEB_ENST00000409198.1_Intron	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2960					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTGTTCATAGTGATGGCATTA	0.371													26	70	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165186888	165186888	+	RNA	DEL	A	A	-	rs56657923		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:165186888delA	ENST00000429636.1	-	0	104																											tctttgtgtgaaaaaaaaaat	0.348													3	3	---	---	---	---					
B3GALT1	8708	broad.mit.edu	37	2	168727836	168727836	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:168727836delA	ENST00000436982.2	-	0	87																											ggtgctacgtaatgcaatgta	0.318													2	4	---	---	---	---					
HOXD13	3239	broad.mit.edu	37	2	176957922	176957922	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:176957922delC	ENST00000392539.3	+	1	304	c.304delC	c.(304-306)ccfs	p.P103fs		NM_000523.3	NP_000514.2	P35453	HXD13_HUMAN	homeobox D13	103					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		CCCGGAGGCTCCCCCAGCCAA	0.716			T	NUP98	AML*								4	7	---	---	---	---					
LOC101927619	101927619	broad.mit.edu	37	2	199165863	199165863	+	RNA	DEL	T	T	-	rs139025808		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:199165863delT	ENST00000456248.1	-	0	751																											TAGAAGACTCTTTTTTTTTTT	0.378													3	3	---	---	---	---					
AC018717.1	0	broad.mit.edu	37	2	199849369	199849370	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:199849369_199849370insG	ENST00000456031.1	-	0	114																											gcaagagagaaggggggagtgc	0.465													2	4	---	---	---	---					
LINC00607	646324	broad.mit.edu	37	2	216706088	216706089	+	RNA	DEL	AA	AA	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:216706088_216706089delAA	ENST00000445174.1	-	0	211					NR_037195.1																						ATCATGTGATAAAAGTTTATGA	0.332													7	2	---	---	---	---					
AAMP	14	broad.mit.edu	37	2	219134765	219134766	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr2:219134765_219134766insG	ENST00000248450.4	-	1	214_215	c.44_45insC	c.(43-45)cctfs	p.P15fs	AAMP_ENST00000444053.1_Frame_Shift_Ins_p.P15fs			Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	15					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding	p.L16fs*9(1)		haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(4)|ovary(2)|skin(1)	11		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGTCTCCAGTGGGGGGGTGTC	0.619													8	98	---	---	---	---					
LMCD1-AS1	100288428	broad.mit.edu	37	3	8331444	8331445	+	RNA	INS	-	-	T	rs148002310	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:8331444_8331445insT	ENST00000420095.1	-	0	571				LMCD1-AS1_ENST00000446281.1_RNA|LMCD1-AS1_ENST00000452802.1_RNA	NR_033378.1																						GCTATTAATCATGAGACATATC	0.421													4	3	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12052379	12052380	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:12052379_12052380insA	ENST00000432424.2	+	0	549							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						ATGTTATCGTGAAAAAAGAGGC	0.371													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18511439	18511440	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:18511439_18511440insA	ENST00000593741.1	+	0	87				AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000598498.1_RNA|AC144521.1_ENST00000598390.1_RNA|AC144521.1_ENST00000595865.1_RNA|AC144521.1_ENST00000456253.2_RNA|AC144521.1_ENST00000593444.1_RNA|AC144521.1_ENST00000599762.1_RNA|AC144521.1_ENST00000596277.1_RNA|AC144521.1_ENST00000414198.1_RNA|AC144521.1_ENST00000598740.1_RNA|AC144521.1_ENST00000596850.1_RNA|AC144521.1_ENST00000598688.1_RNA|AC144521.1_ENST00000595250.1_RNA																							tccccaccccccagccagttgt	0.446													2	4	---	---	---	---					
ENTPD3-AS1	285266	broad.mit.edu	37	3	40400591	40400591	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:40400591delG	ENST00000439293.1	-	0	143																											catcttgtgtggagaacatgc	0.403													2	4	---	---	---	---					
RP11-944L7.4	0	broad.mit.edu	37	3	44723869	44723870	+	RNA	DEL	AT	AT	-	rs10576213		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:44723869_44723870delAT	ENST00000457331.1	-	0	95																											tgaacaaaacatgagattaaat	0.386													4	5	---	---	---	---					
CTD-2185K10.1	0	broad.mit.edu	37	3	59063385	59063386	+	RNA	DEL	AC	AC	-	rs71689126		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:59063385_59063386delAC	ENST00000487624.1	+	0	117																											tctatatcaaacacacacacac	0.446													5	8	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64827280	64827281	+	RNA	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:64827280_64827281insC	ENST00000474768.1	+	0	573				ADAMTS9-AS2_ENST00000481312.1_RNA																							GGGACTATTTTCCCCCCAAAAT	0.302													2	4	---	---	---	---					
PROK2	60675	broad.mit.edu	37	3	71830633	71830634	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:71830633_71830634insT	ENST00000353065.3	-	2	359_360	c.206_207insA	c.(205-207)cccfs	p.P69fs	PROK2_ENST00000295619.3_Frame_Shift_Ins_p.P69fs	NM_021935.3	NP_068754.1	Q9HC23	PROK2_HUMAN	prokineticin 2	69					activation of MAPK activity|angiogenesis|anti-apoptosis|cell proliferation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response|neuropeptide signaling pathway|positive regulation of smooth muscle contraction|sensory perception of pain|spermatogenesis	extracellular region	G-protein-coupled receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.89e-05)|Epithelial(33;0.000173)|LUSC - Lung squamous cell carcinoma(21;0.00168)|Lung(16;0.00306)		GAGTCAGTGGATGGCAGCTGTC	0.465													10	23	---	---	---	---					
LOC728290	728290	broad.mit.edu	37	3	81130732	81130732	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:81130732delG	ENST00000482617.1	+	0	60																											ACAATAGCGTGGATTTGTTGT	0.373													2	4	---	---	---	---					
RP11-451B8.1	0	broad.mit.edu	37	3	87842472	87842473	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:87842472_87842473insG	ENST00000462792.1	-	0	306_307																											AGAGGATTCGCGGGGGGGACGG	0.559													2	4	---	---	---	---					
RP11-325B23.2	0	broad.mit.edu	37	3	98125078	98125079	+	RNA	INS	-	-	C	rs34478586	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:98125078_98125079insC	ENST00000508616.1	+	0	188																											tgaaactatcatatttgcagac	0.361													5	6	---	---	---	---					
PVRL3-AS1	100506555	broad.mit.edu	37	3	110776208	110776209	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:110776208_110776209insG	ENST00000491709.1	-	0	270				PVRL3-AS1_ENST00000467426.1_RNA|PVRL3-AS1_ENST00000463025.1_RNA|PVRL3-AS1_ENST00000474769.1_RNA|PVRL3-AS1_ENST00000476301.1_RNA																							tgcctcctgacgggggggacac	0.574													2	4	---	---	---	---					
TAGLN3	29114	broad.mit.edu	37	3	111718410	111718411	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:111718410_111718411insG	ENST00000393917.2	+	2	693_694	c.141_142insG	c.(139-144)ccgcagfs	p.Q48fs	TAGLN3_ENST00000273368.4_Frame_Shift_Ins_p.Q48fs|TAGLN3_ENST00000455401.2_Frame_Shift_Ins_p.Q48fs|TAGLN3_ENST00000478951.1_Frame_Shift_Ins_p.Q48fs	NM_013259.2	NP_037391.2	Q9UI15	TAGL3_HUMAN	transgelin 3	48	CH.				central nervous system development|muscle organ development					endometrium(2)|lung(5)|urinary_tract(1)	8						ACCCGCCCCCCGGCAGGGCCCA	0.609													11	32	---	---	---	---					
RP11-439C8.1	0	broad.mit.edu	37	3	154554590	154554590	+	RNA	DEL	T	T	-	rs67759446		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:154554590delT	ENST00000478814.1	-	0	226																											cattttgctcttttttttttt	0.363													3	4	---	---	---	---					
IL12A-AS1	101928376	broad.mit.edu	37	3	159700952	159700953	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:159700952_159700953insG	ENST00000497452.1	-	0	1350																											attatttgtctgggggggcgga	0.475													3	3	---	---	---	---					
RP11-10O22.1	0	broad.mit.edu	37	3	162769892	162769893	+	RNA	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:162769892_162769893insT	ENST00000490357.1	+	0	103																											CAATCttttgcttttttttttc	0.371													3	3	---	---	---	---					
LINC01192	647107	broad.mit.edu	37	3	162954463	162954463	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:162954463delT	ENST00000470546.1	-	0	158					NR_033945.1																						aataacttcatttgcatttat	0.358													2	4	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172975961	172975961	+	RNA	DEL	T	T	-	rs11324954		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:172975961delT	ENST00000447709.1	+	0	22																											gttttaggtcttttccactta	0.383													3	4	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177469545	177469545	+	RNA	DEL	A	A	-	rs5854763		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr3:177469545delA	ENST00000442937.1	+	0	428					NR_047568.1																						ctagctggtgagcggagacga	0.483													5	9	---	---	---	---					
RGS12	6002	broad.mit.edu	37	4	3432649	3432650	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:3432649_3432650insCC	ENST00000336727.3	+	17	4985_4986	c.4081_4082insCC	c.(4081-4083)cccfs	p.P1361fs	RGS12_ENST00000382788.3_Frame_Shift_Ins_p.P1361fs|RGS12_ENST00000344733.5_Frame_Shift_Ins_p.P1361fs|RGS12_ENST00000338806.4_Frame_Shift_Ins_p.P713fs|RGS12_ENST00000538395.1_3'UTR	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1361						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCCGCCCTCCACCCCCCAGGAA	0.644													2	4	---	---	---	---					
RP11-722M1.1	0	broad.mit.edu	37	4	36590486	36590487	+	RNA	DEL	TA	TA	-	rs143719922	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:36590486_36590487delTA	ENST00000505298.1	-	0	160																											tgcatgtatctatttttttttt	0.416													3	3	---	---	---	---					
RP11-340A13.2	0	broad.mit.edu	37	4	59867342	59867342	+	RNA	DEL	T	T	-	rs148600865		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:59867342delT	ENST00000513836.1	+	0	54																											ttcattataatttttttttgt	0.343													2	4	---	---	---	---					
RP11-622J8.1	0	broad.mit.edu	37	4	60019386	60019387	+	RNA	DEL	AC	AC	-	rs35488087		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:60019386_60019387delAC	ENST00000512546.1	+	0	53																											atacacacaaacacacacacac	0.347													2	4	---	---	---	---					
UBA6-AS1	550112	broad.mit.edu	37	4	68833083	68833085	+	RNA	DEL	ATT	ATT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:68833083_68833085delATT	ENST00000500538.2	+	0	1905																											AACAAACATCATTAAGATCTGCT	0.305													5	6	---	---	---	---					
RP11-542G1.1	0	broad.mit.edu	37	4	76213005	76213005	+	RNA	DEL	A	A	-	rs10715009		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:76213005delA	ENST00000505930.1	-	0	41																											ACCTCAAAGCAACACCAAATA	0.353													6	0	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82788451	82788452	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:82788451_82788452insG	ENST00000510780.1	-	0	336																											ATAAAAGAGAAGGGGGGAATGg	0.450													2	4	---	---	---	---					
RP11-742B18.1	0	broad.mit.edu	37	4	88515854	88515854	+	RNA	DEL	A	A	-	rs74961386		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:88515854delA	ENST00000506480.1	-	0	322																											ctatggaaataaaaaaaAAAA	0.338													3	4	---	---	---	---					
HPGDS	27306	broad.mit.edu	37	4	95223320	95223321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:95223320_95223321insC	ENST00000295256.5	-	5	501_502	c.411_412insG	c.(409-414)gggagafs	p.R138fs		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	138	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	AGCCATTCTCTCCCCCCTAAAT	0.351													11	664	---	---	---	---					
ADH4	127	broad.mit.edu	37	4	100063853	100063854	+	Frame_Shift_Ins	INS	-	-	G	rs61754858	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:100063853_100063854insG	ENST00000508393.1	-	3	318_319	c.153_154insC	c.(151-156)ccaggcfs	p.G52fs	ADH4_ENST00000265512.7_Frame_Shift_Ins_p.G33fs|ADH4_ENST00000505590.1_Frame_Shift_Ins_p.G52fs|RP11-696N14.1_ENST00000500358.2_RNA|ADH4_ENST00000423445.1_Frame_Shift_Ins_p.G52fs|ADH4_ENST00000504581.1_5'UTR			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	33				T -> S (in Ref. 1; AAA51595 and 2; CAA39813).	alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	TCATGAGCCTTGGGGGGAGCTA	0.510													7	96	---	---	---	---					
LOC256880	256880	broad.mit.edu	37	4	100948188	100948188	+	RNA	DEL	T	T	-	rs146039861		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:100948188delT	ENST00000507494.1	+	0	567				RP11-15B17.1_ENST00000501976.2_RNA|RP11-15B17.1_ENST00000515026.1_RNA																							gctcggcTAATTTTTTTTTTA	0.438													2	4	---	---	---	---					
RP11-729M20.1	0	broad.mit.edu	37	4	105238005	105238005	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:105238005delA	ENST00000514327.1	+	0	162																											gtatgttctcactcataagtg	0.393													2	4	---	---	---	---					
RP11-556I14.2	0	broad.mit.edu	37	4	105662937	105662938	+	RNA	DEL	CA	CA	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:105662937_105662938delCA	ENST00000515127.1	-	0	407																											TGCATGCACGCACACACACACA	0.426													3	6	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128084270	128084271	+	RNA	INS	-	-	T	rs111950085		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:128084270_128084271insT	ENST00000504050.1	-	0	483																											CTGTCTTTGGATTTTTTTTTTT	0.376													3	4	---	---	---	---					
LOC102724776	102724776	broad.mit.edu	37	4	156252206	156252206	+	RNA	DEL	A	A	-	rs34355127		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:156252206delA	ENST00000593387.1	+	0	155				AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000599555.1_RNA|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000597939.1_RNA|AC097467.2_ENST00000595760.1_RNA|AC097467.2_ENST00000593486.1_RNA|AC097467.2_ENST00000512269.1_RNA|AC097467.2_ENST00000597955.1_RNA|AC097467.2_ENST00000595229.1_RNA																							gtaatctcttaaaaaaaaaaa	0.388													4	3	---	---	---	---					
RP11-404J23.1	0	broad.mit.edu	37	4	180337986	180337987	+	RNA	INS	-	-	ACACAC	rs142264849	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:180337986_180337987insACACAC	ENST00000512036.1	-	0	111																											TGTGTGTGTATacacacacaca	0.386													3	3	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190825682	190825683	+	RNA	INS	-	-	T	rs138468383		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:190825682_190825683insT	ENST00000511785.1	-	0	231																											AACTACTGTGATATTTTTTAGA	0.347													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190825928	190825928	+	RNA	DEL	T	T	-	rs139102049		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr4:190825928delT	ENST00000511785.1	-	0	231																											ttaccaaaaatttgaaaaatt	0.532													5	4	---	---	---	---					
FLJ33360	401172	broad.mit.edu	37	5	6313914	6313915	+	RNA	INS	-	-	T	rs33913095	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:6313914_6313915insT	ENST00000507444.1	-	0	143					NR_028351.1																						CTCTTGGGGGCCCCACATCCTC	0.609													5	2	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9767557	9767558	+	RNA	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:9767557_9767558insT	ENST00000511616.1	-	0	521					NR_027112.2																						tgagtcaaatctatgtggctca	0.470													6	0	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21559505	21559506	+	RNA	INS	-	-	CA	rs149099655	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:21559505_21559506insCA	ENST00000607545.1	+	0	314					NR_027026.1																						TCAATAGACtgtagtatgttcg	0.356													3	5	---	---	---	---					
RP11-152K4.2	0	broad.mit.edu	37	5	31140165	31140165	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:31140165delC	ENST00000523584.1	-	0	125																											AAAGAATTGTCCCATTTCAAA	0.358													7	0	---	---	---	---					
LOC100653061	100653061	broad.mit.edu	37	5	34182134	34182134	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:34182134delT	ENST00000514048.1	-	0	231																											ataaaaaggattttttttttt	0.512													4	8	---	---	---	---					
CTD-2194L12.2	0	broad.mit.edu	37	5	37916056	37916057	+	RNA	INS	-	-	C	rs150090715	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:37916056_37916057insC	ENST00000513673.1	-	0	234																											TGTCACACCCACCCCCCCCGAC	0.495													2	4	---	---	---	---					
CTD-2116N24.1	0	broad.mit.edu	37	5	38106663	38106664	+	RNA	DEL	GT	GT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:38106663_38106664delGT	ENST00000513039.2	+	0	233																											gtgtgtgtgcgtgtgtgtgtgt	0.421													2	4	---	---	---	---					
CTD-2116N24.1	0	broad.mit.edu	37	5	38167226	38167227	+	RNA	INS	-	-	C	rs66490313	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:38167226_38167227insC	ENST00000513039.2	+	0	233																											GCCATGCCCCGCCCATCCCATT	0.579													6	0	---	---	---	---					
CTD-2288O8.1	0	broad.mit.edu	37	5	51976778	51976778	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:51976778delC	ENST00000502995.1	-	0	253																											cttagtttggccggataggaa	0.458													3	3	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74250027	74250028	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:74250027_74250028insG	ENST00000505200.1	-	0	335																											aagaagagcatggggggaggcc	0.520													2	4	---	---	---	---					
NR2F1-AS1	441094	broad.mit.edu	37	5	92820375	92820375	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:92820375delG	ENST00000607797.1	-	0	1229				NR2F1-AS1_ENST00000607831.1_RNA|NR2F1-AS1_ENST00000510254.1_RNA|NR2F1-AS1_ENST00000606739.1_RNA|NR2F1-AS1_ENST00000606233.1_RNA	NR_015369.1																						attggataaagagtcaagacc	0.388													2	4	---	---	---	---					
LINC01340	102546227	broad.mit.edu	37	5	96984268	96984269	+	RNA	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:96984268_96984269insT	ENST00000504012.1	+	0	159																											aaacacgaaaattgtgttctga	0.322													2	4	---	---	---	---					
RP11-114J13.1	0	broad.mit.edu	37	5	125554374	125554374	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:125554374delA	ENST00000450613.2	-	0	71																											gtactagcacaaaaacagaca	0.383													2	4	---	---	---	---					
LINC01183	728586	broad.mit.edu	37	5	127164477	127164477	+	RNA	DEL	T	T	-	rs140866462	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:127164477delT	ENST00000514853.2	+	0	467																											gggtattATATTTAGTCCCTT	0.418													2	4	---	---	---	---					
CTB-99A3.1	0	broad.mit.edu	37	5	145967673	145967674	+	RNA	INS	-	-	GAG	rs34318543	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:145967673_145967674insGAG	ENST00000512730.1	+	0	246																											TCTTGCCCAGAGAGTTTACACC	0.450													3	4	---	---	---	---					
LOC102546294	102546294	broad.mit.edu	37	5	147738336	147738336	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:147738336delC	ENST00000501695.3	-	0	429																											gctctggagtcagatttccta	0.338													2	4	---	---	---	---					
LOC101927766	101927766	broad.mit.edu	37	5	159236092	159236092	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:159236092delC	ENST00000522627.1	-	0	3691																											aaccaaataaccagaaagagc	0.284													2	4	---	---	---	---					
CTC-535M15.2	0	broad.mit.edu	37	5	165020743	165020744	+	RNA	DEL	AG	AG	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:165020743_165020744delAG	ENST00000522189.1	+	0	21																											agatagagacagagagagagaA	0.347													2	4	---	---	---	---					
CTC-535M15.2	0	broad.mit.edu	37	5	165046500	165046501	+	RNA	INS	-	-	A	rs71000301		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr5:165046500_165046501insA	ENST00000522189.1	+	0	21																											actgcatcttgaaaaaaaaaaa	0.406													4	3	---	---	---	---					
IRF4	3662	broad.mit.edu	37	6	397185	397185	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:397185delC	ENST00000380956.4	+	5	696	c.570delC	c.(568-570)atfs	p.I190fs	IRF4_ENST00000495137.1_3'UTR	NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	190					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		ACCCGGAAATCCCGTACCAAT	0.567			T	IGH@	MM								23	63	---	---	---	---					
LOC101930126	101930126	broad.mit.edu	37	6	6905227	6905228	+	RNA	INS	-	-	T	rs11394399	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:6905227_6905228insT	ENST00000422310.2	-	0	206																											ggccctctttgtttttttttta	0.495													4	3	---	---	---	---					
RP11-716O23.2	0	broad.mit.edu	37	6	11488029	11488029	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:11488029delG	ENST00000423149.1	+	0	265																											TGGTGTCTTTGGGGGGTTCCA	0.552													6	3	---	---	---	---					
RP11-716O23.2	0	broad.mit.edu	37	6	11491237	11491238	+	RNA	DEL	TA	TA	-	rs59042046		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:11491237_11491238delTA	ENST00000423149.1	+	0	417																											tgtgtgtgtctatgtgcgtgca	0.485													5	3	---	---	---	---					
RP11-239H6.2	0	broad.mit.edu	37	6	20288269	20288269	+	RNA	DEL	C	C	-	rs36011707		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:20288269delC	ENST00000449143.2	+	0	91																											ttcgaagttacagtgaactat	0.433													6	0	---	---	---	---					
RP1-209A6.1	0	broad.mit.edu	37	6	22774614	22774614	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:22774614delA	ENST00000420572.2	-	0	197																											AATTTCACAGAAAAAAAAATG	0.358													2	4	---	---	---	---					
RP1-209A6.1	0	broad.mit.edu	37	6	23009245	23009245	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:23009245delC	ENST00000420572.2	-	0	197																											accctgttctccccccaggaa	0.388													2	4	---	---	---	---					
RP1-240B8.3	0	broad.mit.edu	37	6	62368780	62368780	+	RNA	DEL	A	A	-	rs11367313		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:62368780delA	ENST00000511849.2	-	0	341																											ACTCTGCACTAGTAAAAATTT	0.274													3	3	---	---	---	---					
LOC153910	153910	broad.mit.edu	37	6	142909248	142909249	+	RNA	DEL	AC	AC	-	rs3056404		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr6:142909248_142909249delAC	ENST00000447311.1	-	0	177					NR_027312.1																						acagataaagacacacacacac	0.356													2	4	---	---	---	---					
LOC100505938	100505938	broad.mit.edu	37	7	8346189	8346190	+	RNA	DEL	GC	GC	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:8346189_8346190delGC	ENST00000424460.1	+	0	493				RP4-594A5.1_ENST00000435967.1_lincRNA																							gtgagccactgcgcgctgccgt	0.505													5	8	---	---	---	---					
AC007091.1	0	broad.mit.edu	37	7	19430749	19430750	+	RNA	DEL	GT	GT	-	rs71845932		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:19430749_19430750delGT	ENST00000412563.1	+	0	254																											Ttgtgtgtgcgtgtgtgtgtgt	0.416													2	4	---	---	---	---					
LOC101927668	101927668	broad.mit.edu	37	7	19988155	19988156	+	RNA	DEL	TT	TT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:19988155_19988156delTT	ENST00000449573.1	-	0	535																											gtgactgaaattaggtaacaag	0.381													2	4	---	---	---	---					
LINC01162	104355138	broad.mit.edu	37	7	20992480	20992480	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:20992480delA	ENST00000447262.2	+	0	151																											tgtctcaaagaaaaaaaaaaa	0.473													4	7	---	---	---	---					
AC004009.3	0	broad.mit.edu	37	7	27446565	27446566	+	RNA	INS	-	-	GATGT	rs149252430	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:27446565_27446566insGATGT	ENST00000412413.1	+	0	399																											aggagtccagggagcagcctct	0.550													4	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34498801	34498809	+	RNA	DEL	CTACAAGAG	CTACAAGAG	-	rs71554138		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:34498801_34498809delCTACAAGAG	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						caggcctgccctacaagagctccagaaag	0.392													2	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34604782	34604783	+	RNA	INS	-	-	T	rs148985425	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:34604782_34604783insT	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						TGCAGAATCTATTTTTTTTTCA	0.411													4	4	---	---	---	---					
LINC01449	101928773	broad.mit.edu	37	7	41165504	41165504	+	RNA	DEL	C	C	-	rs35088244		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:41165504delC	ENST00000440213.1	+	0	758																											gggacagatgcccaataaggg	0.507													5	3	---	---	---	---					
AC073325.1	0	broad.mit.edu	37	7	45511098	45511100	+	RNA	DEL	AGG	AGG	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:45511098_45511100delAGG	ENST00000443714.1	+	0	259																											aagaagaagaaggaggaggagga	0.399													4	7	---	---	---	---					
INTS4P2	644619	broad.mit.edu	37	7	65150824	65150825	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:65150824_65150825insG	ENST00000430126.2	+	0	757																											TCACCCCCCCCCCCGTTAAAAT	0.470													2	4	---	---	---	---					
RP5-945F2.3	0	broad.mit.edu	37	7	67715820	67715821	+	RNA	DEL	AT	AT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:67715820_67715821delAT	ENST00000446187.1	-	0	179																											aaaatgaaacatgtgaaaatac	0.411													7	6	---	---	---	---					
RP11-3P22.2	0	broad.mit.edu	37	7	68728678	68728681	+	RNA	DEL	GATG	GATG	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:68728678_68728681delGATG	ENST00000435148.1	-	0	590																											tgggtggttagatggatggatgga	0.436													6	9	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72137126	72137126	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:72137126delT	ENST00000438125.1	-	0	1120							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										agttctctcatttttttgcct	0.483													3	6	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72240740	72240741	+	RNA	INS	-	-	A	rs113111246		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:72240740_72240741insA	ENST00000438125.1	-	0	577							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										gtttaaattagaaaaaaaaaaa	0.361													2	4	---	---	---	---					
LINC00972	100505913	broad.mit.edu	37	7	85057220	85057221	+	RNA	DEL	AG	AG	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:85057220_85057221delAG	ENST00000438065.1	+	0	137																											gtggctcagcagagagagagag	0.500													4	3	---	---	---	---					
DMTF1	9988	broad.mit.edu	37	7	86817443	86817444	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:86817443_86817444insA	ENST00000414194.2	+	13	2231_2232	c.439_440insA	c.(439-441)aaafs	p.K147fs	DMTF1_ENST00000432937.2_Frame_Shift_Ins_p.K325fs|DMTF1_ENST00000331242.7_Frame_Shift_Ins_p.K413fs|DMTF1_ENST00000394703.5_Frame_Shift_Ins_p.K413fs|DMTF1_ENST00000413276.2_Intron			Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	413	Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					ACATGAGAACCAAAAAAACAAC	0.411													7	158	---	---	---	---					
STEAP1	26872	broad.mit.edu	37	7	89790221	89790222	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:89790221_89790222delCA	ENST00000297205.2	+	3	387_388	c.187_188delCA	c.(187-189)cfs	p.H63fs	STEAP2-AS1_ENST00000478318.2_RNA	NM_012449.2	NP_036581.1	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the prostate 1	63					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			kidney(2)|large_intestine(3)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	14	all_hematologic(106;0.112)					AGAACTTCAGCACACACAGGAA	0.436													11	221	---	---	---	---					
RP11-142A5.1	0	broad.mit.edu	37	7	91071764	91071765	+	RNA	INS	-	-	A	rs138831915	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:91071764_91071765insA	ENST00000456952.1	-	0	112																											aagaaagaaagaaagaaagaaa	0.322													3	3	---	---	---	---					
RP11-458K10.1	0	broad.mit.edu	37	7	115306068	115306068	+	RNA	DEL	T	T	-	rs5886784		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:115306068delT	ENST00000471672.1	-	0	210																											CTTTTTAAACTTTTTTCTTTA	0.279													2	4	---	---	---	---					
RP5-1006K12.1	0	broad.mit.edu	37	7	119814991	119814991	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:119814991delG	ENST00000421825.1	+	0	50																											TACATATTCAGGGATGCCAAA	0.398													4	2	---	---	---	---					
POT1-AS1	401398	broad.mit.edu	37	7	124687255	124687255	+	RNA	DEL	G	G	-	rs57107767		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:124687255delG	ENST00000453342.1	+	0	614																											ctgcagaagagggggcctgac	0.458													3	4	---	---	---	---					
RP11-138A9.1	0	broad.mit.edu	37	7	130615856	130615857	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:130615856_130615857insA	ENST00000605249.1	-	0	1108_1109																											TCCTCCTTCCTAAAAAAAAGAA	0.332													3	4	---	---	---	---					
LINC-PINT	378805	broad.mit.edu	37	7	130763042	130763042	+	RNA	DEL	T	T	-	rs5887493		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:130763042delT	ENST00000451786.1	-	0	1524																											gggtacagaattttttttttt	0.463													2	4	---	---	---	---					
AC009784.3	0	broad.mit.edu	37	7	136006098	136006098	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr7:136006098delG	ENST00000445293.2	+	0	614																											cggtgtgtgcggaacccagca	0.567													3	6	---	---	---	---					
LOC101929415	101929415	broad.mit.edu	37	8	57438449	57438449	+	RNA	DEL	A	A	-	rs76133099		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:57438449delA	ENST00000518662.1	+	0	827				LINC00968_ENST00000499425.1_lincRNA|RP11-17A4.2_ENST00000522511.1_RNA																							tcagttcaccaaccaagaggc	0.438													4	3	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	64698704	64698704	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:64698704delC	ENST00000524360.1	-	0	346				RP11-32K4.1_ENST00000523191.1_RNA																							GTAGTAGGGACCCAAAGAAAC	0.333													3	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	65175723	65175723	+	RNA	DEL	T	T	-	rs34672806		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:65175723delT	ENST00000521958.1	-	0	218				RP11-32K4.1_ENST00000523191.1_RNA																							AAAAGGAAGATTTTTTTGCAA	0.378													4	8	---	---	---	---					
RP11-281N10.1	0	broad.mit.edu	37	8	72691847	72691847	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:72691847delA	ENST00000517848.1	-	0	711																											AGCATTTTGGAAAGCATTTAT	0.328													2	4	---	---	---	---					
CTD-3118D11.3	0	broad.mit.edu	37	8	87219991	87219991	+	RNA	DEL	A	A	-	rs34731618		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:87219991delA	ENST00000523112.1	+	0	459																											aatgaaccagaaaaaaaaaat	0.368													4	3	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91240791	91240791	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:91240791delC	ENST00000523406.1	+	0	209					NR_051989.1																						ACCTGCTCCGCTTTTTAAGCA	0.433													6	1	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91302734	91302737	+	RNA	DEL	AAAC	AAAC	-	rs78271158		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:91302734_91302737delAAAC	ENST00000523406.1	+	0	300					NR_051989.1																						tcagtctcaaaaacaaacaaacaa	0.471													7	7	---	---	---	---					
RP11-122C21.1	0	broad.mit.edu	37	8	92702192	92702192	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:92702192delA	ENST00000518416.1	-	0	415																											aatgcaaattaaaactactgt	0.333													3	6	---	---	---	---					
FLJ46284	441369	broad.mit.edu	37	8	93884108	93884108	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:93884108delA	ENST00000504861.2	-	0	55					NR_046114.1																						ggaaaaaaagaaaaaaaaaaa	0.353													3	4	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94442613	94442614	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:94442613_94442614insA	ENST00000501400.1	-	0	1133					NR_033858.1																						cagtgagagtgaaaaaggagga	0.515													2	4	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94456322	94456323	+	RNA	INS	-	-	A	rs71794430		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:94456322_94456323insA	ENST00000501400.1	-	0	1133					NR_033858.1																						gactccatctcaaaaaaaaaaa	0.490													3	6	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96442327	96442328	+	RNA	INS	-	-	T	rs147906220	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:96442327_96442328insT	ENST00000521905.1	+	0	126																											tagagggcagcttctttcacag	0.431													3	5	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	109917647	109917647	+	RNA	DEL	T	T	-	rs111750284		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:109917647delT	ENST00000522244.1	-	0	374																											ATACTCAAACTTTTTTTATAT	0.308													5	7	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117135340	117135340	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:117135340delC	ENST00000505156.2	-	0	1463					NR_046215.1																						CACTGCTTTTCTAGCTTTCAA	0.383													3	3	---	---	---	---					
RP11-103H7.3	0	broad.mit.edu	37	8	127532739	127532739	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:127532739delT	ENST00000519123.1	+	0	187																											GGTACGAttcttttttttttt	0.408													2	4	---	---	---	---					
RP11-89K10.1	0	broad.mit.edu	37	8	127706136	127706143	+	RNA	DEL	TTTTTTTT	TTTTTTTT	-	rs111529276		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:127706136_127706143delTTTTTTTT	ENST00000519880.1	+	0	156																											gcagggaaactttttttttttttttttt	0.495													4	2	---	---	---	---					
CTD-2501M5.1	0	broad.mit.edu	37	8	132321159	132321160	+	RNA	INS	-	-	T	rs11364807		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:132321159_132321160insT	ENST00000524275.1	+	0	127																											tattacttcaattttttttttt	0.297													9	3	---	---	---	---					
LOC101927822	101927822	broad.mit.edu	37	8	134906172	134906173	+	RNA	DEL	CC	CC	-	rs141137808		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:134906172_134906173delCC	ENST00000520149.2	+	0	45																											cacacacacaccccccacaagc	0.441													7	10	---	---	---	---					
RP11-149P24.1	0	broad.mit.edu	37	8	137080132	137080132	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:137080132delT	ENST00000523150.1	+	0	159																											ATTATTGCCCTTTTTTTTTCA	0.363													4	9	---	---	---	---					
RP11-431D12.1	0	broad.mit.edu	37	8	137515336	137515337	+	RNA	INS	-	-	T	rs75519803	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:137515336_137515337insT	ENST00000523232.1	+	0	55																											CTGTAGAGAGGGGTTGCTGTGG	0.406													11	0	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	138932817	138932817	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr8:138932817delT	ENST00000518973.1	-	0	514				RP11-238K6.2_ENST00000519652.1_lincRNA																							CTTCCTTTCCTTTTCCTCGGA	0.453													2	4	---	---	---	---					
RP11-56F10.3	0	broad.mit.edu	37	9	27103850	27103851	+	RNA	DEL	TT	TT	-	rs3063608		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:27103850_27103851delTT	ENST00000522960.1	+	0	447																											gacatttgaatttttttttttt	0.421													6	2	---	---	---	---					
RP11-555J4.4	0	broad.mit.edu	37	9	32642836	32642837	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:32642836_32642837insA	ENST00000430787.1	+	0	1602																											catgttcctgcaaaaaacatga	0.381													2	4	---	---	---	---					
LOC101928438	101928438	broad.mit.edu	37	9	102524769	102524769	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr9:102524769delT	ENST00000427039.1	-	0	190																											gtgatcctcctgcctcagcct	0.463													2	4	---	---	---	---					
LINC00842	643650	broad.mit.edu	37	10	47106120	47106138	+	RNA	DEL	CTGCGTCTTGGGCACAGTA	CTGCGTCTTGGGCACAGTA	-	rs1106368	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:47106120_47106138delCTGCGTCTTGGGCACAGTA	ENST00000422732.2	-	0	435					NR_033957.1																						GAAGCAAGTTCTGCGTCTTGGGCACAGTACTTTATCACC	0.498													4	6	---	---	---	---					
MSMB	4477	broad.mit.edu	37	10	51556783	51556784	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:51556783_51556784insT	ENST00000358559.2	+	3	229_230	c.142_143insT	c.(142-144)aaafs	p.K48fs	MSMB_ENST00000298239.6_Intron|MSMB_ENST00000474170.1_3'UTR	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	48						extracellular space|nucleus		p.I48V(1)		lung(4)|ovary(2)|prostate(1)	7						CAAACACCCAATAAACTCGGAG	0.431													8	43	---	---	---	---					
LINC01515	101928913	broad.mit.edu	37	10	67382266	67382269	+	RNA	DEL	CACA	CACA	-	rs72363309	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:67382266_67382269delCACA	ENST00000433152.3	+	0	720																											TCcacacacgcacacacacacaca	0.377													2	4	---	---	---	---					
RP11-35J23.1	0	broad.mit.edu	37	10	98058186	98058186	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:98058186delG	ENST00000454484.2	-	0	274																											ATAGATGTCTGGAAGGTTGAA	0.388													2	4	---	---	---	---					
LBX1-AS1	399806	broad.mit.edu	37	10	103025111	103025111	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:103025111delG	ENST00000434878.1	+	0	110																											CTTGAAAGCTGGGGGATTGTC	0.507													2	4	---	---	---	---					
CASC2	255082	broad.mit.edu	37	10	119860944	119860944	+	RNA	DEL	A	A	-	rs56767064	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:119860944delA	ENST00000435944.1	+	0	452				CASC2_ENST00000454857.1_RNA|CASC2_ENST00000439517.1_RNA|CASC2_ENST00000414722.1_RNA	NR_026939.1																						TAGGATAGGGAAAAAAAAAGG	0.373													2	4	---	---	---	---					
GRK5	2869	broad.mit.edu	37	10	121207709	121207709	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr10:121207709delC	ENST00000392870.2	+	13	1670	c.1341delC	c.(1339-1341)ttfs	p.F448fs	GRK5_ENST00000369108.3_Frame_Shift_Del_p.F343fs	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	448	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GACACCCCTTCTTCAGGAACA	0.592													15	78	---	---	---	---					
ZBED5-AS1	729013	broad.mit.edu	37	11	10921844	10921845	+	RNA	INS	-	-	GT	rs10596848	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:10921844_10921845insGT	ENST00000530344.1	+	0	67																											TTGCtgtgtccgtgtgtgtgtg	0.480													3	6	---	---	---	---					
GALNT18	374378	broad.mit.edu	37	11	11643012	11643013	+	In_Frame_Ins	INS	-	-	GGG			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:11643012_11643013insGGG	ENST00000227756.4	-	1	539_540	c.128_129insCCC	c.(127-129)gca>gCCCca	p.43_44insP	GALNT18_ENST00000526064.1_5'UTR	NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		CCGGCTCCTGCCCCCGCACATA	0.569													7	15	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28757939	28757940	+	RNA	INS	-	-	GG			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:28757939_28757940insGG	ENST00000513853.1	+	0	220																											CATCTTCTAGTGGGGGGTAAAT	0.406													2	4	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28861911	28861913	+	RNA	DEL	GTG	GTG	-	rs57719747		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:28861911_28861913delGTG	ENST00000513853.1	+	0	304																											AGGATGTGATGTGGTGCATATTC	0.384													5	1	---	---	---	---					
RP11-460B17.3	0	broad.mit.edu	37	11	29397916	29397917	+	RNA	INS	-	-	G	rs147822469	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:29397916_29397917insG	ENST00000525097.1	-	0	243																											CTCCAACAACAGTTACTTATGG	0.386													4	2	---	---	---	---					
RP1-65P5.1	0	broad.mit.edu	37	11	32292819	32292820	+	RNA	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:32292819_32292820insC	ENST00000525689.1	-	0	122																											atttgaatgtgccccccaaagt	0.411													2	4	---	---	---	---					
RP11-148I19.1	0	broad.mit.edu	37	11	42138312	42138312	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:42138312delT	ENST00000534059.1	-	0	129																											TTGCTTTTGCtttttttttct	0.368													2	4	---	---	---	---					
RP11-672A2.1	0	broad.mit.edu	37	11	76428836	76428837	+	RNA	INS	-	-	CTGT	rs148792177	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:76428836_76428837insCTGT	ENST00000525328.1	-	0	41																											ttggttatcgcctgtctcgccc	0.475													2	4	---	---	---	---					
RP11-258O13.1	0	broad.mit.edu	37	11	79316211	79316212	+	RNA	DEL	AA	AA	-	rs5792865		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:79316211_79316212delAA	ENST00000526851.1	-	0	638																											CTTGGTCTGGAAAAAAAAAAAA	0.371													3	3	---	---	---	---					
LOC101928989	101928989	broad.mit.edu	37	11	81845967	81845967	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:81845967delA	ENST00000500502.1	-	0	431																											GTTTACCCTCAaaaaaagtag	0.333													2	4	---	---	---	---					
LOC101928989	101928989	broad.mit.edu	37	11	82105842	82105842	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:82105842delG	ENST00000500502.1	-	0	235																											tcatgaggatggatcccttaa	0.458													6	6	---	---	---	---					
RP11-788M5.3	0	broad.mit.edu	37	11	101058811	101058811	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:101058811delT	ENST00000531772.1	+	0	180																											AAAGGAAGGCTTTTTTTTTTC	0.323													3	5	---	---	---	---					
RP11-563P16.1	0	broad.mit.edu	37	11	103580893	103580893	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:103580893delG	ENST00000533459.1	-	0	127																											CTGAGTGACTGGATACTACTT	0.438													2	4	---	---	---	---					
RP11-563P16.1	0	broad.mit.edu	37	11	103590810	103590811	+	RNA	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:103590810_103590811insT	ENST00000533459.1	-	0	127																											tatcacaaaaagatcattgcta	0.376													7	7	---	---	---	---					
LOC101929473	101929473	broad.mit.edu	37	11	126954593	126954593	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:126954593delT	ENST00000527317.1	+	0	116																											TACCTCCATATTTTTTTTTTT	0.418													4	2	---	---	---	---					
AP002856.5	0	broad.mit.edu	37	11	131210297	131210300	+	RNA	DEL	CAGA	CAGA	-	rs66969023		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr11:131210297_131210300delCAGA	ENST00000606885.1	+	0	146																											gtaaacaattcagacaacagagac	0.377													6	2	---	---	---	---					
RERG	85004	broad.mit.edu	37	12	15262427	15262428	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:15262427_15262428insC	ENST00000256953.2	-	5	552_553	c.216_217insG	c.(214-219)ggacatfs	p.H73fs	RERG_ENST00000538313.1_Frame_Shift_Ins_p.H73fs|RERG_ENST00000546331.1_Frame_Shift_Ins_p.H54fs|RERG_ENST00000536465.1_Frame_Shift_Ins_p.H73fs	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	73					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						CATCGCATGTGCCCCTCCCTCT	0.455													121	211	---	---	---	---					
RP11-444D3.1	0	broad.mit.edu	37	12	24539945	24539946	+	RNA	INS	-	-	CAT	rs144256252	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:24539945_24539946insCAT	ENST00000538905.1	-	0	127																											TTGTAAATGAGCATCTTCGTTT	0.361													4	2	---	---	---	---					
RP11-478B9.1	0	broad.mit.edu	37	12	45476062	45476063	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:45476062_45476063insA	ENST00000548424.1	+	0	448																											AAATTACTCAGAAAAAAAGGGG	0.252													3	6	---	---	---	---					
RP11-221N13.4	0	broad.mit.edu	37	12	66039475	66039475	+	RNA	DEL	A	A	-	rs147274223		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:66039475delA	ENST00000545188.1	+	0	85																											AGTTGTGTCTAAAAAAAAATG	0.284													5	1	---	---	---	---					
RP11-956E11.1	0	broad.mit.edu	37	12	69846632	69846633	+	RNA	INS	-	-	TGTG	rs60688825	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:69846632_69846633insTGTG	ENST00000549261.1	+	0	219																											cccagctaatttgtgtgtgtgt	0.535													4	6	---	---	---	---					
LINC01481	101928062	broad.mit.edu	37	12	70360527	70360527	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:70360527delG	ENST00000549419.1	-	0	144																											CAAGTCTTTTGGTCACTCCAC	0.413													2	4	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	73758574	73758575	+	RNA	INS	-	-	TATCACAGA	rs149973398		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:73758574_73758575insTATCACAGA	ENST00000549058.1	-	0	132																											cacagatatcctatcacagata	0.327													2	4	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76033877	76033878	+	RNA	INS	-	-	GTGTGTGTGT	rs147992363	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:76033877_76033878insGTGTGTGTGT	ENST00000552856.1	-	0	401																											ATGAGTGTATCgtgtgtgtgtg	0.332													3	3	---	---	---	---					
RP11-328J6.1	0	broad.mit.edu	37	12	103519523	103519523	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:103519523delT	ENST00000548594.1	-	0	167				RP11-328J6.1_ENST00000548415.1_RNA																							CATTTCTATCTTTCCTAACTC	0.403													2	4	---	---	---	---					
RP11-497G19.1	0	broad.mit.edu	37	12	117104378	117104378	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:117104378delG	ENST00000546835.1	+	0	665																											AAAATAGTTTGGTTTTGATTT	0.468													2	4	---	---	---	---					
RP11-357K6.3	0	broad.mit.edu	37	12	119337314	119337314	+	RNA	DEL	T	T	-	rs67515257		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:119337314delT	ENST00000544515.1	-	0	95																											TACTTTTGGCTTTTTTTTTTT	0.413													3	5	---	---	---	---					
RP11-768F21.1	0	broad.mit.edu	37	12	120029926	120029926	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr12:120029926delA	ENST00000509470.2	-	0	320																											aactcaaagtaaaaaaaaaaa	0.498													2	4	---	---	---	---					
EDNRB	1910	broad.mit.edu	37	13	78477707	78477708	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:78477707_78477708insA	ENST00000377211.4	-	3	940_941	c.788_789insT	c.(787-789)atgfs	p.M263fs	EDNRB_ENST00000446573.1_Frame_Shift_Ins_p.M173fs|EDNRB_ENST00000334286.5_Frame_Shift_Ins_p.M173fs	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	173					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CCAGCTTACACATCTCAGCTCC	0.460													37	39	---	---	---	---					
CCDC168	643677	broad.mit.edu	37	13	103389011	103389011	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr13:103389011delT	ENST00000322527.2	-	1	148	c.149delA	c.(148-150)agfs	p.K50fs		NM_001146197.1	NP_001139669.1			coiled-coil domain containing 168									p.K50R(2)									TTCTTGTGCCTTTTCCCCTTG	0.413													2	4	---	---	---	---					
BMS1P17	101101776	broad.mit.edu	37	14	19677618	19677621	+	RNA	DEL	AGAA	AGAA	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:19677618_19677621delAGAA	ENST00000418499.3	+	0	711																											tagaaacaatagaaagacatttcc	0.319													3	3	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26353700	26353700	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:26353700delA	ENST00000546412.1	-	0	258																											gctttgctttaaaaaaaaaaa	0.378													2	4	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26484066	26484067	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:26484066_26484067insA	ENST00000546412.1	-	0	258																											ttcatactacccaaaataatct	0.337													3	3	---	---	---	---					
EGLN3	112399	broad.mit.edu	37	14	34519427	34519429	+	RNA	DEL	CTT	CTT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:34519427_34519429delCTT	ENST00000555922.1	+	0	139																											GGCAAGTCTCCTTCTTCCAACCA	0.463													4	3	---	---	---	---					
RP11-116N8.1	0	broad.mit.edu	37	14	36441526	36441527	+	RNA	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:36441526_36441527insC	ENST00000550089.1	+	0	242																											cttccttccttcccccctcctc	0.450													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44805149	44805149	+	RNA	DEL	A	A	-	rs34777545		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:44805149delA	ENST00000553827.1	-	0	69																											tgttatcaccaaaaaaaaaaa	0.289													4	3	---	---	---	---					
AL162759.1	0	broad.mit.edu	37	14	54237154	54237155	+	RNA	INS	-	-	GT	rs33948507	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:54237154_54237155insGT	ENST00000418927.1	-	0	580																											cacacacacacgtcacacacac	0.485													2	4	---	---	---	---					
LINC01500	102723742	broad.mit.edu	37	14	59359891	59359891	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:59359891delA	ENST00000553762.1	+	0	644																											tgggggagagaaattttggtt	0.478													2	4	---	---	---	---					
RP11-72M17.1	0	broad.mit.edu	37	14	66859605	66859605	+	RNA	DEL	G	G	-	rs35762661		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:66859605delG	ENST00000556874.1	-	0	643																											GTGGTTAGTAGTCTCAACAGG	0.323													9	2	---	---	---	---					
RP11-72M17.1	0	broad.mit.edu	37	14	66925044	66925045	+	RNA	INS	-	-	T	rs72516750	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:66925044_66925045insT	ENST00000556874.1	-	0	643																											ccCCCACCAAATTTTTTTTTAA	0.361													2	4	---	---	---	---					
GPATCH2L	55668	broad.mit.edu	37	14	76716619	76716620	+	RNA	DEL	TG	TG	-	rs35287112		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:76716619_76716620delTG	ENST00000554225.1	+	0	187																											Ggtatgtgtatgtgtgtgtgtg	0.411													4	7	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82344835	82344836	+	RNA	INS	-	-	ATA			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:82344835_82344836insATA	ENST00000554814.1	+	0	315																											gtttggggtttataccatctta	0.361													4	4	---	---	---	---					
RP11-61O1.1	0	broad.mit.edu	37	14	98665855	98665856	+	RNA	DEL	CA	CA	-	rs58818713		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr14:98665855_98665856delCA	ENST00000555776.1	-	0	121																											tatgcacatgcacacacacaca	0.460													4	6	---	---	---	---					
CHEK2P2	646096	broad.mit.edu	37	15	20491110	20491111	+	RNA	INS	-	-	A	rs60408042		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:20491110_20491111insA	ENST00000555186.1	+	0	568					NR_038836.1																						CTGCTCTTCATAGGTGGGGTGC	0.559													2	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22336666	22336669	+	RNA	DEL	TTTC	TTTC	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:22336666_22336669delTTTC	ENST00000558896.1	+	0	583																											atttttgttatttcttttcttctg	0.343													4	5	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	36073772	36073772	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:36073772delG	ENST00000501169.2	+	0	462					NR_038251.1																						caggatcattgcaagagatga	0.448													2	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48248508	48248511	+	RNA	DEL	TGTG	TGTG	-	rs3050640		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:48248508_48248511delTGTG	ENST00000560900.1	+	0	195																											GGTTCAGACCtgtgtgtgtgtgtg	0.431													2	4	---	---	---	---					
CTD-2184D3.5	0	broad.mit.edu	37	15	52358961	52358964	+	RNA	DEL	GTGT	GTGT	-	rs34921726		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:52358961_52358964delGTGT	ENST00000558607.1	-	0	54																											ATATATACACgtgtgtgtgtgtgt	0.324													2	4	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61601225	61601226	+	RNA	DEL	AT	AT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:61601225_61601226delAT	ENST00000559783.1	-	0	236																											GGATCAAAACATGTGGATTCGT	0.396													4	2	---	---	---	---					
CTD-2034I4.2	0	broad.mit.edu	37	15	81972262	81972263	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:81972262_81972263insA	ENST00000558153.1	+	0	548				RP11-499F3.2_ENST00000560054.1_lincRNA|CTD-2034I4.1_ENST00000559211.1_lincRNA																							aactcctcaccaaaaatcaaca	0.371													2	4	---	---	---	---					
RP11-152L20.3	0	broad.mit.edu	37	15	92766621	92766621	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:92766621delG	ENST00000561674.1	-	0	185																											GGAAAAAAAAGGGAACCAAGA	0.373													5	1	---	---	---	---					
RP11-266O8.1	0	broad.mit.edu	37	15	93941800	93941801	+	RNA	INS	-	-	G	rs116913778	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr15:93941800_93941801insG	ENST00000543286.1	+	0	545																											TCAAACTGTTCGGGGGCATGAG	0.416													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5538752	5538752	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:5538752delA	ENST00000569895.1	+	0	343																											ggaggattatagtgatgatgg	0.448													3	5	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5944897	5944897	+	RNA	DEL	C	C	-	rs71404559		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:5944897delC	ENST00000569895.1	+	0	436																											gtggcaggtgcctgtagtccc	0.542													3	4	---	---	---	---					
U91319.1	0	broad.mit.edu	37	16	13578887	13578887	+	RNA	DEL	T	T	-	rs74394830		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:13578887delT	ENST00000571619.1	+	0	552																											CCTCTTGTTCttttttttttt	0.413													2	4	---	---	---	---					
CTA-481E9.3	0	broad.mit.edu	37	16	18209608	18209608	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:18209608delA	ENST00000563866.1	-	0	48				CTA-481E9.4_ENST00000567304.1_lincRNA																							GGGAGAAAACAAAAGCCTGAG	0.453													2	4	---	---	---	---					
LCMT1-AS1	102723510	broad.mit.edu	37	16	25110500	25110500	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:25110500delG	ENST00000563962.1	-	0	375																											ccaaagtgctgggggattaca	0.443													2	4	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32123215	32123215	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:32123215delG	ENST00000564145.1	-	0	456																											tattctagaaGGATAAATTAT	0.343													5	5	---	---	---	---					
LOC101927580	101927580	broad.mit.edu	37	16	60020642	60020643	+	RNA	DEL	TG	TG	-	rs72275840		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:60020642_60020643delTG	ENST00000568279.1	+	0	173																											GCAGATAGATtgtgtgtgtgtg	0.356													3	2	---	---	---	---					
AC012322.1	0	broad.mit.edu	37	16	64344744	64344745	+	RNA	DEL	GT	GT	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:64344744_64344745delGT	ENST00000561657.1	-	0	497																											TTCTCATAGGgtgtgtgtgtgt	0.371													3	5	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													7	4	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80476677	80476678	+	RNA	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr16:80476677_80476678insA	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568819.1_RNA|RP11-525K10.3_ENST00000568776.1_RNA																							GAAACTACTTGAAAAAAAAGCA	0.356													2	4	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29559881	29559881	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:29559881delG	ENST00000358273.4	+	26	3861	c.3478delG	c.(3478-3480)gtfs	p.G1160fs	NF1_ENST00000356175.3_Frame_Shift_Del_p.G1160fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1160					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CGTAGACAGTGGTCTCATGCA	0.443			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			34	79	---	---	---	---					
RP11-429O1.1	0	broad.mit.edu	37	17	50574022	50574023	+	RNA	INS	-	-	TGTTT	rs3037739	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:50574022_50574023insTGTTT	ENST00000572848.1	+	0	76																											ACACATGCTCCTGTTTTGTTTG	0.386													2	4	---	---	---	---					
LINC01482	101928104	broad.mit.edu	37	17	66668466	66668467	+	RNA	INS	-	-	G	rs35750602	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:66668466_66668467insG	ENST00000585484.1	+	0	183																											ATACCTCTGATGGGGGGGGAAT	0.376													4	2	---	---	---	---					
LINC01028	101928141	broad.mit.edu	37	17	68060838	68060838	+	RNA	DEL	T	T	-	rs145395425		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr17:68060838delT	ENST00000586373.1	+	0	134				AC002539.1_ENST00000587325.1_RNA|AC002539.1_ENST00000435112.1_RNA																							ccttattttctttttttAAAA	0.453													4	2	---	---	---	---					
LOC101927571	101927571	broad.mit.edu	37	18	20388143	20388156	+	RNA	DEL	CACACACACACACA	CACACACACACACA	-	rs73964332		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:20388143_20388156delCACACACACACACA	ENST00000583086.1	-	0	84				RP11-739L10.1_ENST00000578831.1_RNA																							tttgcattttcacacacacacacacacacacaca	0.379													2	4	---	---	---	---					
LOC729950	729950	broad.mit.edu	37	18	22217706	22217709	+	RNA	DEL	ACAC	ACAC	-	rs150814658		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:22217706_22217709delACAC	ENST00000577994.1	+	0	82					NR_040033.1																						ttacagatttacacacacacacac	0.377													7	0	---	---	---	---					
RP11-746B8.1	0	broad.mit.edu	37	18	30421098	30421098	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:30421098delT	ENST00000582239.1	+	0	393				RP11-746B8.1_ENST00000580366.1_RNA																							TTATTTTGCATTTGAACTCCA	0.428													2	4	---	---	---	---					
LOC642484	642484	broad.mit.edu	37	18	53742894	53742894	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:53742894delA	ENST00000382897.2	-	0	698				RP11-456O19.2_ENST00000589450.1_lincRNA																							actatgtctcaaaaaaaagaa	0.438													2	4	---	---	---	---					
LOC642484	642484	broad.mit.edu	37	18	53841650	53841651	+	RNA	INS	-	-	C			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:53841650_53841651insC	ENST00000382897.2	-	0	698																											AGGTTCTATTGCCCCCATGGAA	0.475													2	4	---	---	---	---					
LOC642484	642484	broad.mit.edu	37	18	53841801	53841802	+	RNA	DEL	TT	TT	-	rs35396184		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr18:53841801_53841802delTT	ENST00000382897.2	-	0	698																											CACCACTCCAtttttttttttt	0.450													3	2	---	---	---	---					
GIPC3	126326	broad.mit.edu	37	19	3586542	3586543	+	Frame_Shift_Ins	INS	-	-	G	rs8113232	byFrequency	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:3586542_3586543insG	ENST00000322315.5	+	2	320_321	c.275_276insG	c.(274-276)cggfs	p.R92fs		NM_133261.2	NP_573568.1	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	92										breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAAGCTCCTGGGGGGTCAGA	0.579											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
CTB-70G10.1	0	broad.mit.edu	37	19	28797752	28797752	+	RNA	DEL	T	T	-	rs142154004		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:28797752delT	ENST00000587777.1	-	0	133																											TTTGTGTTGCTTTTTTTTTTT	0.408													3	4	---	---	---	---					
LOC100420587	100420587	broad.mit.edu	37	19	28979340	28979341	+	RNA	INS	-	-	CTTT	rs35812452	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:28979340_28979341insCTTT	ENST00000592347.1	-	0	642																											GTTAGAACACACTTTCCTTTTT	0.465													3	5	---	---	---	---					
LOC100420587	100420587	broad.mit.edu	37	19	29081062	29081062	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:29081062delG	ENST00000592347.1	-	0	642				AC005616.1_ENST00000589999.1_RNA																							AAGCCCCTTTGGGAGACTGCC	0.632													4	5	---	---	---	---					
LOC284395	284395	broad.mit.edu	37	19	29885126	29885126	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:29885126delC	ENST00000582581.1	-	0	1648					NR_040029.1																						CCCTGGTCCGCCAGCTACCTG	0.537													2	4	---	---	---	---					
CTC-400I9.2	0	broad.mit.edu	37	19	31359610	31359611	+	RNA	INS	-	-	G	rs144612479	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:31359610_31359611insG	ENST00000585364.1	+	0	106																											GACAACTTTAATAAAGTCCTTC	0.450													8	2	---	---	---	---					
HPN-AS1	100128675	broad.mit.edu	37	19	35567534	35567534	+	RNA	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr19:35567534delG	ENST00000392227.2	-	0	404					NR_024562.1																						aaaaaaaaaagaTCCAGGAGT	0.557													3	3	---	---	---	---					
LINC01428	101929265	broad.mit.edu	37	20	7199049	7199050	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:7199049_7199050insG	ENST00000449581.1	-	0	164																											aatccttggttgggggggcgga	0.490													2	4	---	---	---	---					
NCOR1P1	149934	broad.mit.edu	37	20	26085844	26085845	+	RNA	DEL	AG	AG	-	rs112440441		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:26085844_26085845delAG	ENST00000478176.1	-	0	150					NR_003678.1																						agaaaaaaaaagtcagatttgg	0.411													4	2	---	---	---	---					
RP5-1031J8.1	0	broad.mit.edu	37	20	38423275	38423278	+	RNA	DEL	TGTT	TGTT	-	rs79013792		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:38423275_38423278delTGTT	ENST00000444436.1	+	0	211																											gagatggagGTGTTTGTTAAATAC	0.436													3	4	---	---	---	---					
RP5-1121H13.4	0	broad.mit.edu	37	20	40647939	40647940	+	RNA	INS	-	-	T			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:40647939_40647940insT	ENST00000431589.1	+	0	131																											AAATCCCACAGTTTTTTTGGAG	0.446													2	4	---	---	---	---					
RP5-1121H13.4	0	broad.mit.edu	37	20	40657522	40657522	+	RNA	DEL	C	C	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr20:40657522delC	ENST00000431589.1	+	0	131																											ccaggtttttccacctagaaa	0.358													5	4	---	---	---	---					
AP000476.1	0	broad.mit.edu	37	21	25803119	25803119	+	RNA	DEL	T	T	-	rs11347789		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:25803119delT	ENST00000453784.2	+	0	165																											TAGGGAGACATTTTTTCTAAA	0.338													3	4	---	---	---	---					
LOC101927973	101927973	broad.mit.edu	37	21	29562420	29562420	+	RNA	DEL	A	A	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:29562420delA	ENST00000453420.1	-	0	523																											gcctcaccctaatcttaatta	0.373													2	4	---	---	---	---					
LINC00649	100506334	broad.mit.edu	37	21	35343811	35343812	+	RNA	INS	-	-	AC	rs138324381	by1000genomes	TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr21:35343811_35343812insAC	ENST00000427447.1	+	0	2943_2944					NR_038883.1																						TAATCCTGCTAacacacacaca	0.386													5	9	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35389296	35389298	+	RNA	DEL	AGA	AGA	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chr22:35389296_35389298delAGA	ENST00000448318.4	-	0	1184																											gaggtgaaagagaaggagAGAAT	0.345													5	3	---	---	---	---					
RP11-545D19.1	0	broad.mit.edu	37	X	34413360	34413361	+	RNA	INS	-	-	AA	rs61399858		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:34413360_34413361insAA	ENST00000412652.1	-	0	357																											cacacacacacccaatatcagg	0.342													2	4	---	---	---	---					
RP4-769N13.6	0	broad.mit.edu	37	X	101862177	101862177	+	RNA	DEL	T	T	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:101862177delT	ENST00000476910.1	+	0	739				RP4-769N13.7_ENST00000602441.1_RNA																							ccatttgttatttttttttgt	0.358													6	5	---	---	---	---					
NKRF	55922	broad.mit.edu	37	X	118724170	118724171	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:118724170_118724171insA	ENST00000371527.1	-	2	1869_1870	c.1217_1218insT	c.(1216-1218)taafs	p.*406fs	NKRF_ENST00000542113.1_Frame_Shift_Ins_p.*421fs|NKRF_ENST00000487600.1_Intron|NKRF_ENST00000304449.5_Frame_Shift_Ins_p.*406fs	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	406					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						GAAGAATTTTCAAAGCCTCGTC	0.416													37	56	---	---	---	---					
LINC00629	100506757	broad.mit.edu	37	X	133690119	133690120	+	RNA	INS	-	-	G			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:133690119_133690120insG	ENST00000592070.1	+	0	202					NR_038998.1																						GTCAGATTATTGGGGGGTGGGG	0.564													2	4	---	---	---	---					
HTATSF1	27336	broad.mit.edu	37	X	135593890	135593890	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:135593890delG	ENST00000535601.1	+	10	2408	c.1986delG	c.(1984-1986)aafs	p.K662fs	HTATSF1_ENST00000218364.4_Frame_Shift_Del_p.K662fs	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	662	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					CTGATAAAAAGGCGGAAGAAG	0.398													222	202	---	---	---	---					
CDR1	1038	broad.mit.edu	37	X	139866087	139866088	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:139866087_139866088insA	ENST00000370532.2	-	1	635_636	c.444_445insT	c.(442-447)ttgaagfs	p.LK148fs		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	148	6 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CTACGTCTTCCAAAAAAGCCAT	0.436													8	495	---	---	---	---					
SPANXA2-OT1	619455	broad.mit.edu	37	X	140685088	140685089	+	RNA	DEL	AC	AC	-			TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:140685088_140685089delAC	ENST00000421554.1	+	0	572					NR_037183.1																						TTATATATATacacacacacac	0.371													5	10	---	---	---	---					
LINC00894	100272228	broad.mit.edu	37	X	149383401	149383401	+	RNA	DEL	G	G	-	rs34067719		TCGA-17-Z015-01A-01W-0746-08	TCGA-17-Z015-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	770c22ba-b759-433e-8478-b6cf0d685447	5f28439b-9f5d-46dc-9d6e-58d8e1d9143c	g.chrX:149383401delG	ENST00000449111.1	+	0	2830																											GTGGGCAGGAGGCCACTCCTT	0.587													4	3	---	---	---	---					
