Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAGEC1	9947	broad.mit.edu	37	X	140995522	140995522	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:140995522C>A	ENST00000285879.4	+	4	2618	c.2332C>A	c.(2332-2334)Cct>Act	p.P778T	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	778							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCAGAGACCTGTCAGCTC	0.557000										HNSCC(15;0.026)			74	232					9.25274e-37	1.4748e-36	0.139131	1	0
TAF1L	138474	broad.mit.edu	37	9	32630458	32630458	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:32630458C>G	ENST00000242310.4	-	1	5209	c.5120G>C	c.(5119-5121)gGc>gCc	p.G1707A		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1707					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCTACCTTGGCCCTGGCACAT	0.507000													26	133					0	0	0.050027	0	0
OR5R1	219479	broad.mit.edu	37	11	56185534	56185534	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:56185534T>A	ENST00000312253.1	-	1	174	c.175A>T	c.(175-177)Atg>Ttg	p.M59L		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					AAATAGTACATAGGTGTGTGG	0.438000													27	102					0	0	0.144211	0	0
PDCL3	79031	broad.mit.edu	37	2	101183005	101183005	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:101183005A>G	ENST00000264254.6	+	2	425	c.47A>G	c.(46-48)aAa>aGa	p.K16R		NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	16					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding			endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						ATCTTACGCAAAAAGGGTATC	0.512000													14	18					0	0	0.033300	0	0
CAPN10	11132	broad.mit.edu	37	2	241528836	241528836	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:241528836G>A	ENST00000391984.2	+	2	414	c.218G>A	c.(217-219)tGc>tAc	p.C73Y	CAPN10_ENST00000404753.3_Missense_Mutation_p.C73Y|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000391982.2_Missense_Mutation_p.C73Y|CAPN10_ENST00000354082.4_Missense_Mutation_p.C73Y|CAPN10_ENST00000270364.7_Missense_Mutation_p.C73Y	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	73	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		CTGGGGGATTGCTGGTTCCTG	0.607000													8	35					0	0	0.058154	0	0
IGSF1	3547	broad.mit.edu	37	X	130415733	130415733	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:130415733C>T	ENST00000370904.1	-	14	2315	c.1405G>A	c.(1405-1407)Ggc>Agc	p.G469S	IGSF1_ENST00000370903.3_Missense_Mutation_p.G478S|IGSF1_ENST00000370910.1_Missense_Mutation_p.G469S|IGSF1_ENST00000361420.3_Missense_Mutation_p.G478S			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	478	Ig-like C2-type 5.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GTCCCTGTGCCTTTCCCGTCA	0.478000													24	87					0	0	0.083992	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723843	140723843	+	Missense_Mutation	SNP	C	C	G	rs143610564	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140723843C>G	ENST00000253812.6	+	1	243	c.243C>G	c.(241-243)agC>agG	p.S81R	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCGCAAAGCGGCAGCTTGG	0.577000													20	47					0	0	0.076483	0	0
IPP	3652	broad.mit.edu	37	1	46179937	46179937	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:46179937T>C	ENST00000396478.3	-	8	1613	c.1511A>G	c.(1510-1512)gAa>gGa	p.E504G		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	504						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					GGAATATTTTTCTACAGTATG	0.393000													14	53					0	0	0.132662	0	0
LAIR1	3903	broad.mit.edu	37	19	54868136	54868136	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:54868136G>A	ENST00000391743.3	-	5	773	c.493C>T	c.(493-495)Ctc>Ttc	p.L165F	LAIR1_ENST00000474878.1_Missense_Mutation_p.L165F|LAIR1_ENST00000313038.6_Missense_Mutation_p.L176F|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000348231.4_Missense_Mutation_p.L166F|LAIR1_ENST00000391742.2_Missense_Mutation_p.L183F|LAIR1_ENST00000434277.2_Missense_Mutation_p.L182F			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	183						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		AGGCAGAAGAGGACCAGGAGG	0.542000													12	47					0	0	0.105934	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45924191	45924191	+	Silent	SNP	C	C	T	rs138625751		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:45924191C>T	ENST00000395629.2	+	5	1173	c.843C>T	c.(841-843)gaC>gaT	p.D281D	MAPK8IP1_ENST00000241014.2_Silent_p.D291D			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	291	JNK-binding domain (JBD).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		GGCCCCCAGACGCTGCAGAGC	0.672000													7	15					0	0	0.038147	0	0
NUGGC	389643	broad.mit.edu	37	8	27925799	27925799	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:27925799G>A	ENST00000413272.2	-	5	556	c.414C>T	c.(412-414)tgC>tgT	p.C138C	NUGGC_ENST00000341513.6_Silent_p.C138C	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		CTTGTACAATGCAGGAAGTAC	0.498000													3	13					0	0	0.115264	0	0
CLCA4	22802	broad.mit.edu	37	1	87041215	87041215	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:87041215T>A	ENST00000370563.3	+	11	1926	c.1884T>A	c.(1882-1884)aaT>aaA	p.N628K	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	628						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTGGAGCCAATGTGACTGCTT	0.373000													26	87					0	0	0.108266	0	0
GART	2618	broad.mit.edu	37	21	34877985	34877985	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:34877985T>A	ENST00000381831.3	-	20	2871	c.2608A>T	c.(2608-2610)Aat>Tat	p.N870Y	GART_ENST00000381815.4_Missense_Mutation_p.N870Y|GART_ENST00000543717.1_Missense_Mutation_p.N422Y|GART_ENST00000381839.3_Missense_Mutation_p.N870Y	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	870	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	TCTACACGATTTTTATACAGT	0.333000													5	14					0	0	0.014758	0	0
PORCN	64840	broad.mit.edu	37	X	48374534	48374534	+	Splice_Site	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:48374534G>C	ENST00000367574.4	+	11	1432	c.927_splice	c.e11+1	p.L309_splice	PORCN_ENST00000359882.4_Splice_Site_p.L385_splice|PORCN_ENST00000355092.3_Splice_Site_p.L385_splice|PORCN_ENST00000355961.4_Splice_Site_p.L386_splice|PORCN_ENST00000537758.1_Splice_Site_p.L391_splice|PORCN_ENST00000361988.3_Splice_Site_p.L380_splice|PORCN_ENST00000326194.6_Splice_Site_p.L391_splice			Q9H237	PORCN_HUMAN	porcupine homolog (Drosophila)	391					Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGCATCGCTTGGTGAGGGTTC	0.567000													7	23					0	0	0.080935	0	0
OR13C3	138803	broad.mit.edu	37	9	107298670	107298670	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:107298670C>T	ENST00000374781.2	-	1	467	c.425G>A	c.(424-426)tGt>tAt	p.C142Y		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						AAGAAGCAGACATTCTGTTGA	0.458000													68	192					0	0	0.139131	0	0
C2orf78	388960	broad.mit.edu	37	2	74043608	74043608	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:74043608G>A	ENST00000409561.1	+	3	2379	c.2258G>A	c.(2257-2259)cGa>cAa	p.R753Q		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	753										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TACCCTGCTCGACCTGATTCT	0.552000													7	168					0	0	0.047766	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176589	142176589	+	RNA	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:142176589G>C	ENST00000390369.2	-	0	86																											TTGCGACTTTGTACCTTGGGG	0.488000													35	71					0	0	0.074837	0	0
STRA6	64220	broad.mit.edu	37	15	74473151	74473151	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:74473151G>T	ENST00000323940.5	-	18	2057	c.1812C>A	c.(1810-1812)gaC>gaA	p.D604E	STRA6_ENST00000563965.1_Missense_Mutation_p.D643E|STRA6_ENST00000574278.1_Missense_Mutation_p.D619E|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000535552.1_Missense_Mutation_p.D641E|STRA6_ENST00000395105.4_Missense_Mutation_p.D604E|STRA6_ENST00000449139.2_Missense_Mutation_p.D604E|STRA6_ENST00000423167.2_Missense_Mutation_p.D595E|STRA6_ENST00000416286.3_Missense_Mutation_p.D596E	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	604					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						GTCTGAGGCTGTCCTGGGGGG	0.617000													9	29					6.40141e-05	7.12781e-05	0.080935	1	0
ERBB2IP	55914	broad.mit.edu	37	5	65350250	65350250	+	Missense_Mutation	SNP	A	A	T	rs137933401	byFrequency	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:65350250A>T	ENST00000284037.5	+	21	3493	c.3104A>T	c.(3103-3105)aAt>aTt	p.N1035I	ERBB2IP_ENST00000380943.2_Missense_Mutation_p.N1035I|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.N1035I|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.N1035I|ERBB2IP_ENST00000416865.2_Intron|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.N1035I|ERBB2IP_ENST00000380936.1_Missense_Mutation_p.N1035I|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.N1031I|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.N1035I|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.N1035I	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	1035					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AATCATAACAATGTTCGAGCT	0.428000													28	73					0	0	0.116897	0	0
PAX2	5076	broad.mit.edu	37	10	102568895	102568895	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:102568895C>A	ENST00000370296.2	+	8	1440	c.890C>A	c.(889-891)aCc>aAc	p.T297N	PAX2_ENST00000361791.3_Missense_Mutation_p.T274N|PAX2_ENST00000355243.3_Missense_Mutation_p.T274N|PAX2_ENST00000556085.1_Missense_Mutation_p.T273N|PAX2_ENST00000428433.1_Missense_Mutation_p.T297N			Q02962	PAX2_HUMAN	paired box 2	297					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CCAGCCCTGACCCCTGGGCTT	0.562000													14	39					2.23348e-06	2.60712e-06	0.146539	1	0
IFNA14	3448	broad.mit.edu	37	9	21239770	21239770	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:21239770G>C	ENST00000380222.2	-	1	208	c.165C>G	c.(163-165)gaC>gaG	p.D55E		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	55					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGTCATGTCTGTCCTTCAGGC	0.478000													24	80					0	0	0.091800	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	25					0	0	0.115264	0	0
GRK4	2868	broad.mit.edu	37	4	2990509	2990509	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:2990509G>T	ENST00000398052.4	+	3	547	c.204G>T	c.(202-204)agG>agT	p.R68S	GRK4_ENST00000345167.6_Missense_Mutation_p.R36S|GRK4_ENST00000398051.4_Missense_Mutation_p.R36S|GRK4_ENST00000504933.1_Missense_Mutation_p.R68S	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	68	N-terminal.|RGS.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GTCTCTTCAGGCAGTTCTGTG	0.418000													10	55					5.16669e-11	6.84531e-11	0.080935	1	0
AP4E1	23431	broad.mit.edu	37	15	51293309	51293309	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:51293309C>G	ENST00000261842.5	+	20	3288	c.3182C>G	c.(3181-3183)tCt>tGt	p.S1061C	AP4E1_ENST00000560508.1_Missense_Mutation_p.S986C|AP4E1_ENST00000561397.1_3'UTR	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	1061					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		ATGTCAGAATCTCAAGCTGCA	0.338000													36	61					0	0	0.086207	0	0
CLEC4A	50856	broad.mit.edu	37	12	8288251	8288251	+	Silent	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:8288251A>G	ENST00000229332.5	+	4	616	c.369A>G	c.(367-369)gaA>gaG	p.E123E	CLEC4A_ENST00000352620.3_Silent_p.E90E|CLEC4A_ENST00000345999.3_Silent_p.E51E|CLEC4A_ENST00000360500.3_Silent_p.E84E	NM_016184.3|NM_194447.2|NM_194450.2	NP_057268.1|NP_919429.2|NP_919432.1	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A	123	C-type lectin.				cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)	11				Kidney(36;0.0915)		TTTCTACTGAATCAGCATCTT	0.443000													36	61					0	0	0.117977	0	0
IGKV3D-20	28874	broad.mit.edu	37	2	90078162	90078162	+	RNA	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:90078162C>A	ENST00000390270.2	+	0	296																											GGCGCCCAGGCTCCTCATCTA	0.597000													30	101					9.78485e-24	1.49148e-23	0.054565	1	0
CD34	947	broad.mit.edu	37	1	208072370	208072370	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:208072370G>A	ENST00000356522.4	-	3	785	c.464C>T	c.(463-465)aCa>aTa	p.T155I	CD34_ENST00000537704.1_Intron|CD34_ENST00000310833.7_Missense_Mutation_p.T155I|CD34_ENST00000485761.1_5'UTR	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	155					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						AGTGGGAGATGTTGCAAGGCT	0.473000													48	199					0	0	0.139131	0	0
TRPM2	7226	broad.mit.edu	37	21	45784063	45784063	+	Silent	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:45784063C>G	ENST00000397928.1	+	3	766	c.321C>G	c.(319-321)acC>acG	p.T107T	TRPM2_ENST00000300481.9_Silent_p.T107T|TRPM2_ENST00000397932.2_Silent_p.T107T|TRPM2_ENST00000300482.5_Silent_p.T107T	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	107						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						AGCCCCACACCTTCCAGGGCA	0.572000													4	12					0	0	0.009096	0	0
BHMT2	23743	broad.mit.edu	37	5	78379105	78379105	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:78379105G>T	ENST00000255192.3	+	6	755	c.689G>T	c.(688-690)gGg>gTg	p.G230V	BHMT2_ENST00000521567.1_Missense_Mutation_p.G166V|DMGDH_ENST00000520388.1_Intron	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	230	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GAGTGGGCAGGGCTGAAAGCG	0.582000													25	60					9.39395e-14	1.32869e-13	0.116897	1	0
PABPC5	140886	broad.mit.edu	37	X	90690938	90690938	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:90690938C>A	ENST00000312600.3	+	2	576	c.362C>A	c.(361-363)gCc>gAc	p.A121D	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	121	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						GACAATAGGGCCCTGTTTTAC	0.438000													18	88					5.03518e-11	6.69935e-11	0.043863	1	0
THOC2	57187	broad.mit.edu	37	X	122757644	122757644	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:122757644G>C	ENST00000245838.8	-	28	3528	c.3497C>G	c.(3496-3498)gCt>gGt	p.A1166G	THOC2_ENST00000491737.1_Missense_Mutation_p.A1051G|THOC2_ENST00000355725.4_Missense_Mutation_p.A1166G	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1166					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TTACCCCATAGCCAATGCATA	0.343000													20	62					0	0	0.083992	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630051	9630051	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:9630051C>A	ENST00000382492.2	-	1	412	c.94G>T	c.(94-96)Ggc>Tgc	p.G32C	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	32					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						AAGTCAATGCCATTCACCACC	0.393000													17	89					1.99824e-07	2.45096e-07	0.033300	1	0
NET1	10276	broad.mit.edu	37	10	5498644	5498644	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:5498644T>G	ENST00000355029.4	+	12	1620	c.1478T>G	c.(1477-1479)tTc>tGc	p.F493C	NET1_ENST00000380359.3_Missense_Mutation_p.F439C|NET1_ENST00000542715.1_Missense_Mutation_p.F312C	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	493	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						CAGCAGTGGTTCAACTGTATT	0.552000													16	65					0	0	0.091800	0	0
DSC3	1825	broad.mit.edu	37	18	28602406	28602406	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:28602406G>T	ENST00000434452.1	-	7	992	c.838C>A	c.(838-840)Ctg>Atg	p.L280M	DSC3_ENST00000360428.4_Missense_Mutation_p.L280M	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	280	Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTGTATTTCAGGCGCGTATGC	0.458000													31	86					8.4185e-14	1.19611e-13	0.050027	1	0
TMEM260	54916	broad.mit.edu	37	14	57078984	57078984	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:57078984A>G	ENST00000261556.6	+	7	960	c.838A>G	c.(838-840)Agt>Ggt	p.S280G	TMEM260_ENST00000538838.1_Missense_Mutation_p.S280G|TMEM260_ENST00000553335.1_3'UTR|TMEM260_ENST00000536419.1_5'UTR	NM_017799.3	NP_060269.3			transmembrane protein 260																		AATAGGATCCAGTATGTCTGA	0.299000													14	32					0	0	0.043863	0	0
GOLGA4	2803	broad.mit.edu	37	3	37343688	37343688	+	Missense_Mutation	SNP	G	G	A	rs141780526	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:37343688G>A	ENST00000361924.2	+	10	1473	c.1099G>A	c.(1099-1101)Gca>Aca	p.A367T	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000435830.2_3'UTR|GOLGA4_ENST00000356847.4_Missense_Mutation_p.A389T	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	367	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AATGGTAATCGCAGAGACAAA	0.388000													12	24					0	0	0.105934	0	0
THRAP3	9967	broad.mit.edu	37	1	36754665	36754665	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:36754665C>G	ENST00000354618.5	+	5	1269	c.1045C>G	c.(1045-1047)Cta>Gta	p.L349V	THRAP3_ENST00000469141.2_Missense_Mutation_p.L349V	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	349					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAATAGGTATCTAGAAGAGCA	0.353000			T	USP6	aneurysmal bone cysts								12	75					0	0	0.105934	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815833	23815833	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:23815833A>T	ENST00000264867.2	-	8	1392	c.1273T>A	c.(1273-1275)Tct>Act	p.S425T	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	425					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TCTGTGGAAGAACAAATCTGC	0.438000													19	60					0	0	0.043863	0	0
SYF2	25949	broad.mit.edu	37	1	25554002	25554002	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:25554002C>A	ENST00000236273.4	-	5	423	c.398G>T	c.(397-399)cGc>cTc	p.R133L	SYF2_ENST00000354361.3_Missense_Mutation_p.R91L	NM_015484.4	NP_056299.1	O95926	SYF2_HUMAN	SYF2 pre-mRNA-splicing factor	133						catalytic step 2 spliceosome				kidney(1)|large_intestine(1)|lung(4)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		ATGATACTGGCGTAACTGGGC	0.373000													19	99					0.000175454	0.000193988	0.055883	1	0
IL12RB2	3595	broad.mit.edu	37	1	67792502	67792502	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:67792502A>G	ENST00000262345.1	+	4	1089	c.449A>G	c.(448-450)gAc>gGc	p.D150G	IL12RB2_ENST00000371000.1_Missense_Mutation_p.D150G|IL12RB2_ENST00000544434.1_Missense_Mutation_p.D150G|IL12RB2_ENST00000541374.1_Missense_Mutation_p.D150G	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	150	Fibronectin type-III 1.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						AGAGGACGAGACACCCACTTA	0.413000													5	30					0	0	0.029380	0	0
FLNB	2317	broad.mit.edu	37	3	58095863	58095863	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:58095863G>C	ENST00000357272.4	+	16	2615	c.2450G>C	c.(2449-2451)gGg>gCg	p.G817A	FLNB_ENST00000348383.5_Missense_Mutation_p.G817A|FLNB_ENST00000358537.3_Missense_Mutation_p.G817A|FLNB_ENST00000295956.4_Missense_Mutation_p.G817A|FLNB_ENST00000493452.1_Missense_Mutation_p.G648A|FLNB_ENST00000429972.2_Missense_Mutation_p.G817A|FLNB_ENST00000419752.2_Missense_Mutation_p.G648A|FLNB_ENST00000490882.1_Missense_Mutation_p.G817A			O75369	FLNB_HUMAN	filamin B, beta	817					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCTGCTGCTGGGCGATACACT	0.498000													27	64					0	0	0.125774	0	0
PLCL2	23228	broad.mit.edu	37	3	17056386	17056386	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:17056386G>A	ENST00000418129.2	+	3	3088	c.2623G>A	c.(2623-2625)Gta>Ata	p.V875I	PLCL2_ENST00000396755.2_Missense_Mutation_p.V875I|PLCL2_ENST00000432376.1_Missense_Mutation_p.V875I	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1001					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GAAGAAGATCGTAACAACTTA	0.488000													7	106					0	0	0.047766	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551817	58551817	+	Splice_Site	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:58551817G>C	ENST00000282326.1	+	4	617		c.e4-1			NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CTCCCGCACAGTTCTGGTATC	0.582000													5	39					0	0	0.029380	0	0
ABCB5	340273	broad.mit.edu	37	7	20782578	20782578	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:20782578G>T	ENST00000404938.2	+	25	3755	c.3103G>T	c.(3103-3105)Ggc>Tgc	p.G1035C	ABCB5_ENST00000258738.6_Missense_Mutation_p.G590C	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	590					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CATCCTCCGTGGCTTATCCCT	0.463000													19	111					5.03518e-11	6.69935e-11	0.043863	1	0
OR6V1	346517	broad.mit.edu	37	7	142749650	142749650	+	Silent	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:142749650A>T	ENST00000418316.1	+	1	234	c.213A>T	c.(211-213)gtA>gtT	p.V71V		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					AGATCTTGGTAACCATGACTG	0.493000													72	312					0	0	0.139131	0	0
SOGA2	23255	broad.mit.edu	37	18	8824940	8824940	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:8824940G>T	ENST00000359865.3	+	15	3574	c.3432G>T	c.(3430-3432)gaG>gaT	p.E1144D	SOGA2_ENST00000518815.1_Missense_Mutation_p.E469D|SOGA2_ENST00000306329.11_Missense_Mutation_p.E1463D|SOGA2_ENST00000517570.1_Missense_Mutation_p.E1103D|SOGA2_ENST00000306285.7_Missense_Mutation_p.E469D|SOGA2_ENST00000400050.3_Missense_Mutation_p.E1103D	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1454																	CAGGGCACGAGGACAGCACAG	0.627000													9	43					5.50884e-06	6.35947e-06	0.093190	1	0
DLGAP1	9229	broad.mit.edu	37	18	3879466	3879466	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:3879466C>G	ENST00000315677.3	-	4	1198	c.603G>C	c.(601-603)tgG>tgC	p.W201C	DLGAP1_ENST00000515196.2_Missense_Mutation_p.W201C|DLGAP1_ENST00000584874.1_Missense_Mutation_p.W201C|DLGAP1_ENST00000581527.1_Missense_Mutation_p.W201C|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	201					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CCGAGCTCCACCAGCCCGGGG	0.701000													17	74					0	0	0.108266	0	0
REG1P	5969	broad.mit.edu	37	2	79365175	79365175	+	RNA	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:79365175T>A	ENST00000444841.1	-	0	83																											GCAGTGAATCTCTTGCTTAAG	0.468000													6	34					0	0	0.029380	0	0
ACAN	176	broad.mit.edu	37	15	89398511	89398511	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:89398511C>G	ENST00000439576.2	+	12	3069	c.2695C>G	c.(2695-2697)Ctg>Gtg	p.L899V	ACAN_ENST00000352105.7_Missense_Mutation_p.L899V|ACAN_ENST00000561243.1_Missense_Mutation_p.L899V|ACAN_ENST00000559004.1_Missense_Mutation_p.L899V	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	899					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTCTGGAGACCTGGACTCCAG	0.572000													6	12					0	0	0.029380	0	0
DCHS1	8642	broad.mit.edu	37	11	6647186	6647186	+	Silent	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:6647186T>A	ENST00000299441.3	-	17	7107	c.6696A>T	c.(6694-6696)acA>acT	p.T2232T		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2232	Cadherin 21.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCAGGATGGCTGTGGTAGTGA	0.582000													9	24					0	0	0.069234	0	0
NETO1	81832	broad.mit.edu	37	18	70417732	70417732	+	Missense_Mutation	SNP	C	C	A	rs140307788	byFrequency	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:70417732C>A	ENST00000327305.6	-	9	1763	c.1106G>T	c.(1105-1107)cGt>cTt	p.R369L	NETO1_ENST00000299430.2_Missense_Mutation_p.R368L|NETO1_ENST00000583169.1_Missense_Mutation_p.R369L	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	369					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity	p.R369H(1)		NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		ATACTTTTTACGAGGCTGTTT	0.458000													40	108					5.85753e-14	8.36029e-14	0.139131	1	0
TMC5	79838	broad.mit.edu	37	16	19501836	19501836	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:19501836A>G	ENST00000396229.2	+	18	3442	c.2693A>G	c.(2692-2694)tAt>tGt	p.Y898C	TMC5_ENST00000381414.4_Intron|TMC5_ENST00000564959.1_Missense_Mutation_p.Y581C|TMC5_ENST00000219821.5_Missense_Mutation_p.Y652C|TMC5_ENST00000561503.1_Missense_Mutation_p.Y539C|TMC5_ENST00000542583.2_Missense_Mutation_p.Y898C|TMC5_ENST00000541464.1_Missense_Mutation_p.Y846C	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	898						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GTTTGGATCTATCGGAACCTC	0.522000													62	195					0	0	0.139131	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135770096	135770096	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:135770096G>C	ENST00000250617.6	-	11	2445	c.1240C>G	c.(1240-1242)Ctc>Gtc	p.L414V	ARHGEF6_ENST00000535227.1_Missense_Mutation_p.L287V|ARHGEF6_ENST00000370620.1_Missense_Mutation_p.L260V|ARHGEF6_ENST00000370622.1_Missense_Mutation_p.L260V	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	414	DH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					CCTACCATGAGAGTTTTGAAT	0.353000													19	68					0	0	0.069288	0	0
PPFIA4	8497	broad.mit.edu	37	1	203033008	203033008	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:203033008C>T	ENST00000367240.2	+	24	3391	c.2864C>T	c.(2863-2865)cCc>cTc	p.P955L	PPFIA4_ENST00000295706.4_Missense_Mutation_p.P461L|PPFIA4_ENST00000599966.1_Missense_Mutation_p.P461L|PPFIA4_ENST00000447715.2_Missense_Mutation_p.P954L|PPFIA4_ENST00000414050.2_Missense_Mutation_p.P683L|PPFIA4_ENST00000272198.6_Missense_Mutation_p.P470L			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	470					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						GAATGGCTACCCAGCCTGGGG	0.592000													20	62					0	0	0.076483	0	0
SCN3A	6328	broad.mit.edu	37	2	165971985	165971985	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:165971985G>T	ENST00000360093.3	-	19	3985	c.3494C>A	c.(3493-3495)cCg>cAg	p.P1165Q	SCN3A_ENST00000283254.7_Missense_Mutation_p.P1165Q|SCN3A_ENST00000409101.3_Missense_Mutation_p.P1116Q	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1165						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACAAGCTTCCGGTTTAAGGTC	0.388000													15	47					3.41278e-10	4.48374e-10	0.033300	1	0
NELL1	4745	broad.mit.edu	37	11	20805255	20805255	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:20805255C>A	ENST00000298925.5	+	4	451	c.298C>A	c.(298-300)Cat>Aat	p.H100N	NELL1_ENST00000325319.5_Missense_Mutation_p.H72N|NELL1_ENST00000532434.1_Missense_Mutation_p.H72N|NELL1_ENST00000357134.5_Missense_Mutation_p.H72N			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	72	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity	p.H72Y(1)		NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TGCAGCTCCTCATGTGAGTGA	0.443000													15	74					2.4624e-09	3.16882e-09	0.049695	1	0
AKR7A2	8574	broad.mit.edu	37	1	19633560	19633560	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:19633560T>C	ENST00000235835.3	-	5	745	c.724A>G	c.(724-726)Aag>Gag	p.K242E		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	242					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCCGTCCTTGTCCTCATAC	0.632000													17	48					0	0	0.033300	0	0
LOC642943	642943	broad.mit.edu	37	9	95646901	95646901	+	RNA	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:95646901C>T	ENST00000446878.1	+	0	435				ANKRD19P_ENST00000473204.1_RNA																							GCTTTCACAACTGCAGAGGTG	0.612000													65	159					0	0	0.139131	0	0
KLHL13	90293	broad.mit.edu	37	X	117043455	117043455	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:117043455T>C	ENST00000371876.1	-	4	3443	c.1022A>G	c.(1021-1023)tAt>tGt	p.Y341C	KLHL13_ENST00000371882.1_Missense_Mutation_p.Y341C|KLHL13_ENST00000371878.1_Missense_Mutation_p.Y341C|KLHL13_ENST00000541812.1_Missense_Mutation_p.Y376C|KLHL13_ENST00000540167.1_Missense_Mutation_p.Y376C|KLHL13_ENST00000545703.1_Missense_Mutation_p.Y350C|KLHL13_ENST00000539496.1_Missense_Mutation_p.Y395C|KLHL13_ENST00000469946.1_Missense_Mutation_p.Y341C|KLHL13_ENST00000262820.3_Missense_Mutation_p.Y392C			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	392					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GCCAACCACATAGAGAAAATT	0.443000													18	84					0	0	0.069288	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601241	13601241	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:13601241G>A	ENST00000040738.5	-	10	7418	c.7283C>T	c.(7282-7284)gCg>gTg	p.A2428V		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2428							DNA binding										TTCTTTTTCCGCACAAACAGC	0.547000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	295					0	0	0.029380	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869626	151869626	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:151869626C>G	ENST00000329342.5	+	3	541	c.316C>G	c.(316-318)Caa>Gaa	p.Q106E		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	106							protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GTCTGAGTTCCAAGCAGCACT	0.542000													23	115					0	0	0.083992	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873578	91873578	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:91873578C>A	ENST00000373094.1	+	7	4528	c.3683C>A	c.(3682-3684)gCt>gAt	p.A1228D	PCDH11X_ENST00000361655.2_Missense_Mutation_p.A1210D|PCDH11X_ENST00000298274.8_Missense_Mutation_p.A1191D|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000373088.1_Missense_Mutation_p.A1191D|PCDH11X_ENST00000373097.1_Missense_Mutation_p.A1218D|PCDH11X_ENST00000406881.1_Missense_Mutation_p.A1220D	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1228					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CTAGTGCAGGCTACTGCACTT	0.597000													50	209					6.07242e-22	9.21131e-22	0.139131	1	0
GUCY2D	3000	broad.mit.edu	37	17	7918200	7918200	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:7918200C>A	ENST00000254854.4	+	14	2750	c.2600C>A	c.(2599-2601)aCg>aAg	p.T867K		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	867					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GCCTTGAAGACGGGGACACCA	0.602000													10	21					2.27111e-07	2.7428e-07	0.093190	1	0
SLC18A3	6572	broad.mit.edu	37	10	50819611	50819611	+	Missense_Mutation	SNP	C	C	A	rs145315435	byFrequency	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:50819611C>A	ENST00000374115.3	+	1	1265	c.825C>A	c.(823-825)aaC>aaA	p.N275K	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	275					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CTCGGGCCAACCTGCCAGTGG	0.657000													7	23					1.99824e-07	2.45096e-07	0.033300	1	0
EMP3	2014	broad.mit.edu	37	19	48830831	48830831	+	Silent	SNP	G	G	T	rs139549534		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:48830831G>T	ENST00000270221.6	+	3	433	c.132G>T	c.(130-132)acG>acT	p.T44T	EMP3_ENST00000597279.1_Silent_p.T44T|EMP3_ENST00000596315.1_5'UTR	NM_001425.2	NP_001416.1	P54852	EMP3_HUMAN	epithelial membrane protein 3	44					cell growth|negative regulation of cell proliferation	integral to membrane				lung(1)	1		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		ACGACTGCACGTGGAACAACG	0.552000													3	24					0.000602214	0.000654309	0.014758	1	0
SLC6A19	340024	broad.mit.edu	37	5	1216989	1216989	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:1216989A>C	ENST00000304460.10	+	8	1158	c.1102A>C	c.(1102-1104)Aac>Cac	p.N368H		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	368					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCAGCGGTGCAACGCCTCCGA	0.617000													5	38					0	0	0.014758	0	0
POLR2M	81488	broad.mit.edu	37	15	58006742	58006742	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:58006742A>T	ENST00000299638.3	+	4	1186	c.972A>T	c.(970-972)caA>caT	p.Q324H	POLR2M_ENST00000380557.4_Missense_Mutation_p.Q167H|GCOM1_ENST00000484300.1_3'UTR|GCOM1_ENST00000587652.1_Missense_Mutation_p.Q721H|GCOM1_ENST00000380568.3_Missense_Mutation_p.K438M|GCOM1_ENST00000380569.2_Missense_Mutation_p.Q506H|POLR2M_ENST00000380563.2_Intron	NM_015532.3	NP_056347.1			polymerase (RNA) II (DNA directed) polypeptide M																		AGGAGATGCAAGCAAAGCTCG	0.398000													55	119					0	0	0.139131	0	0
BNC1	646	broad.mit.edu	37	15	83926700	83926700	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:83926700T>C	ENST00000345382.2	-	5	2564	c.2479A>G	c.(2479-2481)Atg>Gtg	p.M827V	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.M820V	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	827					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						AGACTGCCCATTCGACTTGTT	0.512000													24	80					0	0	0.125774	0	0
PTPRD	5789	broad.mit.edu	37	9	8528597	8528597	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:8528597G>T	ENST00000381196.4	-	12	1078	c.535C>A	c.(535-537)Cga>Aga	p.R179R	PTPRD_ENST00000486161.1_Silent_p.R179R|PTPRD_ENST00000356435.5_Silent_p.R179R|PTPRD_ENST00000463477.1_Silent_p.R179R|PTPRD_ENST00000355233.5_Silent_p.R179R|PTPRD_ENST00000397606.3_Silent_p.R179R|PTPRD_ENST00000397611.3_Silent_p.R179R|PTPRD_ENST00000397617.3_Silent_p.R179R|PTPRD_ENST00000358503.5_Silent_p.R179R|PTPRD_ENST00000540109.1_Silent_p.R179R|PTPRD_ENST00000360074.4_Silent_p.R179R|PTPRD_ENST00000537002.1_Silent_p.R179R	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	179	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R179*(4)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTACCTGATCGTAACTGCTTA	0.328000										TSP Lung(15;0.13)			35	175					3.54909e-21	5.33212e-21	0.124865	1	0
AP1G1	164	broad.mit.edu	37	16	71787790	71787790	+	Splice_Site	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:71787790C>A	ENST00000299980.4	-	13	1671	c.1229_splice	c.e13-1	p.K410_splice	AP1G1_ENST00000569748.1_Splice_Site_p.K410_splice|AP1G1_ENST00000423132.2_Splice_Site_p.K413_splice|AP1G1_ENST00000393512.3_Splice_Site_p.K413_splice|AP1G1_ENST00000433195.2_Splice_Site_p.K433_splice	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	410					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				AAGGTGCATACCTGAAAAAAA	0.423000													37	112					4.00102e-26	6.2194e-26	0.086207	1	0
KIAA0232	9778	broad.mit.edu	37	4	6873323	6873323	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:6873323T>C	ENST00000307659.5	+	8	4279	c.3824T>C	c.(3823-3825)aTa>aCa	p.I1275T	KIAA0232_ENST00000425103.1_Missense_Mutation_p.I1275T	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	1275							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						AACACTGATATACAAGGAATG	0.348000													21	95					0	0	0.108266	0	0
SNRPD1	6632	broad.mit.edu	37	18	19203777	19203777	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:19203777C>T	ENST00000300413.4	+	3	323	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	SNRPD1_ENST00000582475.1_Nonsense_Mutation_p.Q10*|SNRPD1_ENST00000579618.1_Intron	NM_006938.2	NP_008869.1	P62314	SMD1_HUMAN	small nuclear ribonucleoprotein D1 polypeptide 16kDa	54					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding|RNA binding			lung(2)|prostate(1)	3						AGAACCTGTACAGCTGGAAAC	0.388000													11	58					0	0	0.093190	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873562	91873562	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:91873562C>T	ENST00000373094.1	+	7	4512	c.3667C>T	c.(3667-3669)Cct>Tct	p.P1223S	PCDH11X_ENST00000361655.2_Missense_Mutation_p.P1205S|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P1186S|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P1186S|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P1213S|PCDH11X_ENST00000406881.1_Missense_Mutation_p.P1215S	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1223					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCACCACAGTCCTCCTCTAGT	0.587000													53	201					0	0	0.139131	0	0
TAB3	257397	broad.mit.edu	37	X	30873050	30873050	+	Silent	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:30873050A>G	ENST00000378933.1	-	3	909	c.732T>C	c.(730-732)acT>acC	p.T244T	TAB3_ENST00000288422.2_Silent_p.T244T|TAB3_ENST00000378930.3_Silent_p.T244T|TAB3_ENST00000378932.2_Silent_p.T244T	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	244	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						TACTCTGAGGAGTTTGTCTTC	0.463000													7	11					0	0	0.029380	0	0
OR51B5	282763	broad.mit.edu	37	11	5364598	5364598	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:5364598G>C	ENST00000300773.2	-	1	211	c.157C>G	c.(157-159)Ctt>Gtt	p.L53V	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L53I(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTCATGAAGATTGTGATCT	0.502000													25	84					0	0	0.099896	0	0
RBM10	8241	broad.mit.edu	37	X	47039331	47039331	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:47039331G>T	ENST00000377604.3	+	10	1696	c.954G>T	c.(952-954)ggG>ggT	p.G318G	RBM10_ENST00000468791.1_Intron|RBM10_ENST00000329236.7_Silent_p.G241G|RBM10_ENST00000345781.6_Silent_p.G241G	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	318	RRM 2.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						CCATCCTGGGGGCCCTGGCAC	0.592000													7	9					3.09899e-07	3.72828e-07	0.047766	1	0
PKHD1	5314	broad.mit.edu	37	6	51524198	51524198	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:51524198A>T	ENST00000371117.3	-	61	11001	c.10726T>A	c.(10726-10728)Tgg>Agg	p.W3576R		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3576					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.W3576R(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ACTATTTCCCAGCCTTTTTCT	0.423000													47	67					0	0	0.139131	0	0
IPP	3652	broad.mit.edu	37	1	46179938	46179938	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:46179938C>A	ENST00000396478.3	-	8	1612	c.1510G>T	c.(1510-1512)Gaa>Taa	p.E504*		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	504						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					GAATATTTTTCTACAGTATGA	0.393000													14	53					2.32078e-09	2.99887e-09	0.132662	1	0
OBP2A	29991	broad.mit.edu	37	9	138439035	138439035	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:138439035G>T	ENST00000539850.1	+	3	244	c.218G>T	c.(217-219)cGg>cTg	p.R73L	OBP2A_ENST00000371776.1_Missense_Mutation_p.R73L|OBP2A_ENST00000340780.3_Missense_Mutation_p.R73L|OBP2A_ENST00000342114.4_Silent_p.S28S			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	73					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		AGGGAGGATCGGTGCATCCAG	0.642000													4	48					8.12818e-05	9.01855e-05	0.029380	1	0
VCAN	1462	broad.mit.edu	37	5	82786291	82786291	+	Splice_Site	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:82786291G>T	ENST00000265077.3	+	3	1010	c.445_splice	c.e3+1	p.G149_splice	VCAN_ENST00000513984.1_Splice_Site_p.G149_splice|VCAN_ENST00000343200.5_Splice_Site_p.G149_splice|VCAN_ENST00000502527.2_Splice_Site_p.G149_splice|VCAN_ENST00000342785.4_Splice_Site_p.G149_splice|VCAN_ENST00000512590.2_Splice_Site_p.G101_splice	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	149					cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GACTGTGGATGGTAAGGCTTT	0.463000													22	59					4.72057e-08	5.92904e-08	0.091800	1	0
SCML2	10389	broad.mit.edu	37	X	18264765	18264765	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:18264765A>T	ENST00000251900.4	-	13	1913	c.1754T>A	c.(1753-1755)cTa>cAa	p.L585Q	SCML2_ENST00000398048.3_Missense_Mutation_p.L321Q	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	585					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					GTCCCCAACTAGTGGTGAACT	0.413000													28	113					0	0	0.134883	0	0
FGD1	2245	broad.mit.edu	37	X	54472781	54472781	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:54472781G>C	ENST00000375135.3	-	18	3380	c.2647C>G	c.(2647-2649)Cgg>Ggg	p.R883G		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	883	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CTGTCAGGCCGCTCCCCTGCC	0.632000													9	14					0	0	0.080935	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													4	140					0	0	0.021553	0	0
TNNT2	7139	broad.mit.edu	37	1	201335967	201335967	+	Splice_Site	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:201335967T>C	ENST00000509001.1	-	7	488	c.203_splice	c.e7+1	p.R68_splice	TNNT2_ENST00000236918.7_Splice_Site_p.R73_splice|TNNT2_ENST00000367320.2_Splice_Site_p.R77_splice|TNNT2_ENST00000458432.2_Splice_Site_p.R80_splice|TNNT2_ENST00000367322.1_Splice_Site_p.R68_splice|TNNT2_ENST00000421663.2_Splice_Site_p.R70_splice|TNNT2_ENST00000360372.4_Splice_Site_p.R63_splice|TNNT2_ENST00000367315.2_Splice_Site_p.R68_splice|TNNT2_ENST00000367317.4_Splice_Site_p.R68_splice|TNNT2_ENST00000367318.5_Splice_Site_p.R68_splice	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	78					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						CCCACTCACCTGGGCTTTGGT	0.622000													13	77					0	0	0.146539	0	0
WDR44	54521	broad.mit.edu	37	X	117570673	117570673	+	Silent	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:117570673T>C	ENST00000254029.3	+	14	2255	c.1860T>C	c.(1858-1860)ttT>ttC	p.F620F	WDR44_ENST00000371825.3_Silent_p.F620F|WDR44_ENST00000371822.5_Silent_p.F595F	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	620						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						AGAACTACTTTCTTCTTTCTT	0.318000													11	26					0	0	0.093190	0	0
PDIA4	9601	broad.mit.edu	37	7	148702415	148702415	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:148702415T>A	ENST00000286091.4	-	9	1572	c.1340A>T	c.(1339-1341)gAg>gTg	p.E447V		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	447					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			AAAGGTGTACTCAGGGAAGTC	0.587000											OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	38					0	0	0.104719	0	0
ETV7	51513	broad.mit.edu	37	6	36334711	36334711	+	Silent	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:36334711C>G	ENST00000373738.1	-	6	1529	c.684G>C	c.(682-684)ctG>ctC	p.L228L	ETV7_ENST00000340181.4_Silent_p.L283L|ETV7_ENST00000339796.5_Silent_p.L283L|ETV7_ENST00000373737.4_Silent_p.L206L|ETV7_ENST00000538992.1_Silent_p.L132L	NM_001207036.1	NP_001193965.1	Q9Y603	ETV7_HUMAN	ets variant 7	283					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(4)	10						AATAGTGGCGCAGGGCACGAG	0.532000													49	52					0	0	0.139131	0	0
HBM	3042	broad.mit.edu	37	16	216613	216613	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:216613C>T	ENST00000356815.3	+	3	352	c.332C>T	c.(331-333)tCc>tTc	p.S111F	HBM_ENST00000472539.1_3'UTR	NM_001003938.3	NP_001003938.1	Q6B0K9	HBM_HUMAN	hemoglobin, mu	111						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GTGCTGGCCTCCCACCTGCAG	0.647000													3	25					0	0	0.115264	0	0
OR5P2	120065	broad.mit.edu	37	11	7818426	7818426	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:7818426C>G	ENST00000329434.2	-	1	94	c.64G>C	c.(64-66)Gat>Cat	p.D22H	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATTGGATCATCTGTTAAGCCC	0.428000													28	55					0	0	0.099896	0	0
OR4N5	390437	broad.mit.edu	37	14	20611982	20611982	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:20611982C>A	ENST00000333629.1	+	1	88	c.88C>A	c.(88-90)Cta>Ata	p.L30I		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GGTCTTTGTGCTAGTCTTAAT	0.428000													77	242					3.86735e-44	6.25952e-44	0.139131	1	0
SPIN4	139886	broad.mit.edu	37	X	62570191	62570191	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:62570191C>T	ENST00000374884.2	-	1	1032	c.454G>A	c.(454-456)Gac>Aac	p.D152N	SPIN4-AS1_ENST00000451979.1_RNA|SPIN4_ENST00000335144.3_Missense_Mutation_p.D170N			Q56A73	SPIN4_HUMAN	spindlin family, member 4	170					gamete generation					endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	11						TCTTTGTAGTCATCAAGCAGC	0.478000													31	147					0	0	0.064281	0	0
COX10-AS1	100874058	broad.mit.edu	37	17	13927814	13927814	+	RNA	SNP	A	A	T	rs141406384	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:13927814A>T	ENST00000602743.1	-	0	224																											TTGGTGGGAGACGCTCAAGAG	0.512000													6	16					0	0	0.080935	0	0
CSHL1	1444	broad.mit.edu	37	17	61987508	61987508	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:61987508G>A	ENST00000450719.3	-	3	440	c.203C>T	c.(202-204)cCa>cTa	p.P68L	CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000561003.1_Missense_Mutation_p.P79L|CSHL1_ENST00000309894.5_Intron|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000346606.6_Intron			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GGGGACCCCTGGTGCCACCCT	0.572000													15	61					0	0	0.055883	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554673	140554673	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140554673C>A	ENST00000231137.3	+	1	2431	c.2257C>A	c.(2257-2259)Ctg>Atg	p.L753M		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		753					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L753L(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGGTGTGCCTGACTGGAGG	0.582000													11	244					6.72482e-11	8.87225e-11	0.132662	1	0
SALL1	6299	broad.mit.edu	37	16	51174345	51174345	+	Silent	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:51174345C>G	ENST00000440970.1	-	2	1928	c.1497G>C	c.(1495-1497)ggG>ggC	p.G499G	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_Silent_p.G596G	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	596					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACTCAGGGCCCCCGGAGTCAC	0.607000													7	22					0	0	0.058154	0	0
PRKCG	5582	broad.mit.edu	37	19	54401312	54401312	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:54401312C>A	ENST00000536044.1	+	9	1247	c.951C>A	c.(949-951)tgC>tgA	p.C317*	PRKCG_ENST00000540413.1_Missense_Mutation_p.H347N|PRKCG_ENST00000263431.3_Missense_Mutation_p.H347N|PRKCG_ENST00000542049.1_Missense_Mutation_p.H234N			P05129	KPCG_HUMAN	protein kinase C, gamma	0				RVRM -> VSRT (in Ref. 3; AAA60102).	activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		AGGACGCCTGCACATCTCCGA	0.612000													4	25					2.0095e-06	2.35441e-06	0.029380	1	0
ADGB	79747	broad.mit.edu	37	6	147109743	147109743	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:147109743A>T	ENST00000397944.3	+	33	4610	c.4534A>T	c.(4534-4536)Att>Ttt	p.I1512F	ADGB_ENST00000367488.1_Missense_Mutation_p.I235F|ADGB_ENST00000367493.3_3'UTR	NM_024694.3	NP_078970.3	Q8N7X0	CAN7L_HUMAN	androglobin	1512					oxygen transport|proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|heme binding|oxygen binding			breast(1)|endometrium(2)|kidney(2)	5						GAAGGAAAACATTCGTAAGTA	0.413000													3	5					0	0	0.115264	0	0
FN1	2335	broad.mit.edu	37	2	216295507	216295507	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:216295507G>A	ENST00000354785.4	-	5	985	c.616C>T	c.(616-618)Caa>Taa	p.Q206*	FN1_ENST00000432072.2_Nonsense_Mutation_p.Q206*|FN1_ENST00000421182.1_Nonsense_Mutation_p.Q206*|FN1_ENST00000359671.1_Nonsense_Mutation_p.Q206*|FN1_ENST00000357867.4_Nonsense_Mutation_p.Q206*|FN1_ENST00000357009.2_Nonsense_Mutation_p.Q206*|FN1_ENST00000356005.4_Nonsense_Mutation_p.Q206*|FN1_ENST00000345488.5_Nonsense_Mutation_p.Q206*|FN1_ENST00000336916.4_Nonsense_Mutation_p.Q206*|FN1_ENST00000323926.6_Nonsense_Mutation_p.Q206*|FN1_ENST00000426059.1_Nonsense_Mutation_p.Q206*|FN1_ENST00000446046.1_Nonsense_Mutation_p.Q206*|FN1_ENST00000443816.1_Nonsense_Mutation_p.Q206*|FN1_ENST00000346544.3_Nonsense_Mutation_p.Q206*			P02751	FINC_HUMAN	fibronectin 1	206	Fibrin- and heparin-binding 1.|Fibronectin type-I 4.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATCCAGCCTTGGTAGGGCTTC	0.438000													9	33					0	0	0.058154	0	0
MYH4	4622	broad.mit.edu	37	17	10368833	10368833	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:10368833C>T	ENST00000255381.2	-	5	541	c.431G>A	c.(430-432)cGa>cAa	p.R144Q	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	144	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTTTTTGCCTCGGTAGGCTGT	0.542000													37	74					0	0	0.092188	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701625	56701625	+	Silent	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:56701625C>G	ENST00000586855.2	-	5	1372	c.1059G>C	c.(1057-1059)ccG>ccC	p.P353P	ZSCAN5B_ENST00000358992.3_Silent_p.P353P			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	353					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ATGCAAAGGGCGGCAGGGCCT	0.527000													18	97					0	0	0.062417	0	0
TCN1	6947	broad.mit.edu	37	11	59620776	59620776	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:59620776G>T	ENST00000257264.3	-	8	1244	c.1140C>A	c.(1138-1140)cgC>cgA	p.R380R		NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	380					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCCCCATGAGCGCTCCTCCA	0.458000													19	59					1.33834e-09	1.73652e-09	0.043863	1	0
C10orf71	118461	broad.mit.edu	37	10	50531470	50531470	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:50531470G>T	ENST00000374144.3	+	3	1168	c.880G>T	c.(880-882)Gct>Tct	p.A294S	C10orf71_ENST00000323868.4_Missense_Mutation_p.A294S			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	294										endometrium(1)	1						AAAGGACACAGCTGGAACCGT	0.537000													41	101					5.20837e-25	8.0168e-25	0.104719	1	0
MYH6	4624	broad.mit.edu	37	14	23863473	23863473	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:23863473G>T	ENST00000405093.3	-	21	2559	c.2489C>A	c.(2488-2490)cCc>cAc	p.P830H	MYH6_ENST00000356287.3_Missense_Mutation_p.P830H	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	830			P -> L (in CMD1EE).		adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTTCATCCAGGGCCAATTCTT	0.552000													17	48					9.16793e-09	1.16078e-08	0.033300	1	0
KCNH1	3756	broad.mit.edu	37	1	211263912	211263912	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:211263912G>T	ENST00000367007.4	-	4	600	c.431C>A	c.(430-432)tCa>tAa	p.S144*	KCNH1_ENST00000271751.4_Nonsense_Mutation_p.S144*	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	144	PAC.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACCTTTACATGAATCATCCTC	0.348000													20	90					1.42536e-11	1.91266e-11	0.099896	1	0
KCNA2	3737	broad.mit.edu	37	1	111146839	111146839	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:111146839C>G	ENST00000485317.1	-	3	1239	c.566G>C	c.(565-567)cGg>cCg	p.R189P	KCNA2_ENST00000525120.1_Intron|KCNA2_ENST00000440270.1_Missense_Mutation_p.R189P|KCNA2_ENST00000316361.4_Missense_Mutation_p.R189P|KCNA2_ENST00000369770.3_Missense_Mutation_p.R189P			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	189						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ATTCTCATCCCGGAAGATGGG	0.502000													24	64					0	0	0.116897	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645521	13645521	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:13645521C>A	ENST00000361205.4	+	7	1454	c.786C>A	c.(784-786)caC>caA	p.H262Q	LDLRAD4_ENST00000586765.1_Missense_Mutation_p.H207Q|LDLRAD4_ENST00000587757.1_Missense_Mutation_p.H225Q|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.H262Q|LDLRAD4_ENST00000399848.3_Missense_Mutation_p.H244Q|LDLRAD4_ENST00000592991.1_Missense_Mutation_p.H164Q|LDLRAD4_ENST00000585931.1_Missense_Mutation_p.H185Q	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		TGGGCCACCACCCAGGCGCCT	0.607000													13	25					9.31168e-06	1.07101e-05	0.105934	1	0
SPTB	6710	broad.mit.edu	37	14	65239517	65239517	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:65239517C>A	ENST00000389722.3	-	25	5387	c.5334G>T	c.(5332-5334)atG>atT	p.M1778I	SPTB_ENST00000542895.1_Missense_Mutation_p.M1778I|SPTB_ENST00000389720.3_Missense_Mutation_p.M1778I|SPTB_ENST00000389721.5_Missense_Mutation_p.M1778I|SPTB_ENST00000556626.1_Missense_Mutation_p.M1778I	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1778					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGTCTGCCCACATCTCGTTCA	0.637000													9	41					2.27111e-07	2.7428e-07	0.093190	1	0
STYK1	55359	broad.mit.edu	37	12	10772762	10772762	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:10772762T>C	ENST00000075503.3	-	11	1770	c.1250A>G	c.(1249-1251)tAc>tGc	p.Y417C		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	417						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity	p.Y417C(1)		breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						GCTATAGTTGTAGAAGAGGCT	0.448000										HNSCC(73;0.22)			79	102					0	0	0.139131	0	0
IL13RA2	3598	broad.mit.edu	37	X	114245312	114245312	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:114245312A>T	ENST00000371936.1	-	7	850	c.601T>A	c.(601-603)Tat>Aat	p.Y201N	IL13RA2_ENST00000243213.1_Missense_Mutation_p.Y201N			Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2	201	Fibronectin type-III 2.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(6)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	23						GCCTCCAAATAGGGAAATCTG	0.368000													15	70					0	0	0.132662	0	0
CRX	1406	broad.mit.edu	37	19	48343114	48343114	+	Missense_Mutation	SNP	G	G	T	rs138146799		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:48343114G>T	ENST00000221996.7	+	4	996	c.790G>T	c.(790-792)Gtg>Ttg	p.V264L	TPRX2P_ENST00000535362.1_Intron|CRX_ENST00000539067.1_Missense_Mutation_p.V264L	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	264					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		CTACAGCCCCGTGGATAGCTT	0.612000													39	187					1.23103e-26	1.9231e-26	0.131918	1	0
CPA3	1359	broad.mit.edu	37	3	148597578	148597578	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:148597578G>T	ENST00000296046.3	+	6	530	c.478G>T	c.(478-480)Ggg>Tgg	p.G160W	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	160					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAAATAGATTGGGGAAAAGAA	0.373000													11	46					7.03913e-09	9.02157e-09	0.093190	1	0
OR2T3	343173	broad.mit.edu	37	1	248637525	248637525	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:248637525C>A	ENST00000359594.2	+	1	899	c.874C>A	c.(874-876)Ccc>Acc	p.P292T		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTGCTGAACCCCCTCATTTA	0.488000													59	465					6.25564e-26	9.67621e-26	0.139131	1	0
DIDO1	11083	broad.mit.edu	37	20	61513366	61513366	+	Silent	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr20:61513366C>A	ENST00000266070.4	-	16	4267	c.3942G>T	c.(3940-3942)ctG>ctT	p.L1314L	DIDO1_ENST00000395343.1_Silent_p.L1314L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1314					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GGATGTGCTCCAGCGGTGATG	0.622000													3	3					6.4e-05	7.12781e-05	0.115264	1	0
FAM47A	158724	broad.mit.edu	37	X	34149363	34149363	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:34149363G>T	ENST00000346193.3	-	1	1084	c.1033C>A	c.(1033-1035)Cgt>Agt	p.R345S		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	345										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GACCCCCGACGAGTCTTGGAA	0.667000													20	64					2.44723e-14	3.52491e-14	0.099896	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913900	77913900	+	Silent	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:77913900T>A	ENST00000321110.1	-	2	313	c.18A>T	c.(16-18)gcA>gcT	p.A6A		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	6							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TATAGGAGGCTGCTAAGTCCT	0.473000													10	34					0	0	0.069234	0	0
MAP10	54627	broad.mit.edu	37	1	232942878	232942878	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:232942878G>C	ENST00000418460.1	+	1	2236	c.2109G>C	c.(2107-2109)aaG>aaC	p.K703N		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		CTGAAGATAAGTATTTAGATT	0.363000													6	7					0	0	0.038147	0	0
OR6K2	81448	broad.mit.edu	37	1	158669686	158669686	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:158669686A>T	ENST00000359610.2	-	1	800	c.757T>A	c.(757-759)Ttt>Att	p.F253I		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					ACACTGCCAAAGAAGAGCGAA	0.478000													19	104					0	0	0.069288	0	0
RIPPLY1	92129	broad.mit.edu	37	X	106145412	106145412	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:106145412G>T	ENST00000276173.4	-	2	218	c.189C>A	c.(187-189)tcC>tcA	p.S63S	RIPPLY1_ENST00000411805.1_Intron|CLDN2_ENST00000541806.1_Intron	NM_138382.2	NP_612391.1	Q0D2K3	RIPP1_HUMAN	ripply transcriptional repressor 1	63					negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus				lung(1)|urinary_tract(1)	2						AGTCATTTGTGGAAGACAGCC	0.517000													9	20					4.3838e-07	5.25387e-07	0.105934	1	0
CD163L1	283316	broad.mit.edu	37	12	7586213	7586213	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:7586213G>C	ENST00000313599.3	-	3	259	c.202C>G	c.(202-204)Cag>Gag	p.Q68E	CD163L1_ENST00000396630.1_Missense_Mutation_p.Q68E|CD163L1_ENST00000416109.2_Missense_Mutation_p.Q68E			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	68	SRCR 1.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GTCCCCCACTGTCCCTGGAAT	0.498000													61	221					0	0	0.139131	0	0
NFATC4	4776	broad.mit.edu	37	14	24839231	24839231	+	Silent	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:24839231T>C	ENST00000413692.2	+	3	960	c.816T>C	c.(814-816)ttT>ttC	p.F272F	NFATC4_ENST00000554661.1_Silent_p.F139F|NFATC4_ENST00000424781.2_Silent_p.F222F|NFATC4_ENST00000555453.1_Silent_p.F197F|NFATC4_ENST00000539237.2_Silent_p.F241F|NFATC4_ENST00000422617.3_Silent_p.F197F|NFATC4_ENST00000440487.2_3'UTR|NFATC4_ENST00000553708.1_Silent_p.F209F|NFATC4_ENST00000557451.1_Silent_p.F139F|NFATC4_ENST00000553469.1_Silent_p.F241F|NFATC4_ENST00000553879.1_Silent_p.F139F|NFATC4_ENST00000554344.1_Silent_p.F139F|NFATC4_ENST00000556279.1_Silent_p.F241F|NFATC4_ENST00000556169.1_Silent_p.F197F|NFATC4_ENST00000554050.1_Silent_p.F209F|NFATC4_ENST00000555590.1_Silent_p.F222F|NFATC4_ENST00000250373.4_Silent_p.F209F|NFATC4_ENST00000554966.1_Silent_p.F222F|NFATC4_ENST00000554591.1_Silent_p.F272F	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	209	2 approximate SP repeats.|Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CCTCCCGCTTTGGCCTGGGCT	0.682000													8	15					0	0	0.047766	0	0
SV2B	9899	broad.mit.edu	37	15	91832761	91832761	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:91832761G>T	ENST00000394232.1	+	12	2189	c.1719G>T	c.(1717-1719)atG>atT	p.M573I	SV2B_ENST00000330276.4_Missense_Mutation_p.M573I|SV2B_ENST00000545111.2_Missense_Mutation_p.M422I	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	573					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GTGGCTCCATGCTAATCTCTG	0.527000													21	92					7.41945e-09	9.47036e-09	0.108266	1	0
TDRD5	163589	broad.mit.edu	37	1	179631373	179631373	+	Silent	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:179631373C>T	ENST00000444136.1	+	15	2707	c.2457C>T	c.(2455-2457)agC>agT	p.S819S	TDRD5_ENST00000367614.1_Silent_p.S765S|TDRD5_ENST00000294848.8_Silent_p.S765S	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	810					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TTACTGCAAGCCTTGGTGGAA	0.448000													12	50					0	0	0.119110	0	0
ATG2B	55102	broad.mit.edu	37	14	96761865	96761865	+	Silent	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:96761865T>A	ENST00000359933.4	-	35	6065	c.5172A>T	c.(5170-5172)acA>acT	p.T1724T	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1724										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CAGAAAGACTTGTGAAGAAAT	0.308000													16	50					0	0	0.083992	0	0
DDX60L	91351	broad.mit.edu	37	4	169377245	169377245	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:169377245C>T	ENST00000511577.1	-	7	1029	c.782G>A	c.(781-783)cGt>cAt	p.R261H	DDX60L_ENST00000505890.1_Missense_Mutation_p.R261H|DDX60L_ENST00000260184.7_Missense_Mutation_p.R261H			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	261							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ACAGAGAACACGCTGGATGTC	0.398000													10	50					0	0	0.080935	0	0
MIR381HG	378881	broad.mit.edu	37	14	101515008	101515008	+	RNA	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:101515008A>G	ENST00000553692.1	+	0	28				MIR544A_ENST00000384855.1_RNA																							ttcatcacctagggatcttgt	0.408000													4	10					0	0	0.014758	0	0
DNAH17	8632	broad.mit.edu	37	17	76498745	76498745	+	Silent	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:76498745G>C	ENST00000389840.5	-	33	5209	c.5085C>G	c.(5083-5085)acC>acG	p.T1695T	DNAH17-AS1_ENST00000598378.1_3'UTR|DNAH17_ENST00000585328.1_Silent_p.T1703T					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGCCCACCTCGGTCGTCCACC	0.532000													4	8					0	0	0.014758	0	0
KIF21B	23046	broad.mit.edu	37	1	200956012	200956012	+	Missense_Mutation	SNP	G	G	T	rs79881792		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:200956012G>T	ENST00000332129.2	-	26	3965	c.3649C>A	c.(3649-3651)Ctg>Atg	p.L1217M	KIF21B_ENST00000422435.2_Missense_Mutation_p.L1217M|KIF21B_ENST00000461742.2_Missense_Mutation_p.L1217M|KIF21B_ENST00000360529.5_Missense_Mutation_p.L1217M	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1217					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTTCTCGTCAGCGGGGACGTC	0.547000													3	16					1.23904e-05	1.40963e-05	0.014758	1	0
ELK1	2002	broad.mit.edu	37	X	47496438	47496438	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:47496438G>A	ENST00000247161.3	-	5	1261	c.1162C>T	c.(1162-1164)Cgt>Tgt	p.R388C	ELK1_ENST00000343894.4_Missense_Mutation_p.P95L|ELK1_ENST00000376983.3_Missense_Mutation_p.R388C|ELK1_ENST00000592066.1_Missense_Mutation_p.R334C	NM_005229.4	NP_005220.2	P19419	ELK1_HUMAN	ELK1, member of ETS oncogene family	388	Sufficient for interaction with MAD2L2.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	10						GCCGGGCTACGGGGCGCAATG	0.617000													3	12					0	0	0.009096	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431376	106431376	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:106431376G>T	ENST00000407775.2	+	2	295	c.45G>T	c.(43-45)ccG>ccT	p.P15P	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	15					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TTCAAGGGCCGCTTGAAGATG	0.398000													11	29					2.27111e-07	2.7428e-07	0.093190	1	0
DSG3	1830	broad.mit.edu	37	18	29036401	29036401	+	Splice_Site	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:29036401A>T	ENST00000257189.4	+	2	131		c.e2-1			NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3						cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AAATGTCTGCAGGTGGTCATA	0.244000													8	48					0	0	0.080935	0	0
PCDH19	57526	broad.mit.edu	37	X	99662938	99662938	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:99662938C>A	ENST00000373034.4	-	1	2333	c.658G>T	c.(658-660)Ggc>Tgc	p.G220C	PCDH19_ENST00000420881.2_Missense_Mutation_p.G220C|PCDH19_ENST00000255531.7_Missense_Mutation_p.G220C	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	220	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CCAACGGTGCCCAGGCGCGGC	0.607000													7	18					1.52009e-12	2.06627e-12	0.132662	1	0
FAM155B	27112	broad.mit.edu	37	X	68749571	68749571	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:68749571G>A	ENST00000252338.4	+	3	1233	c.1191G>A	c.(1189-1191)caG>caA	p.Q397Q		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	398						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						accaccaacagtaccatcact	0.592000													5	24					0	0	0.038147	0	0
XIRP2	129446	broad.mit.edu	37	2	168103802	168103802	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:168103802T>C	ENST00000409195.1	+	9	5989	c.5900T>C	c.(5899-5901)gTt>gCt	p.V1967A	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.V1745A|XIRP2_ENST00000295237.9_Missense_Mutation_p.V1967A|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1792					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTCATCAGGTTGCTGTCCAG	0.448000													30	93					0	0	0.050027	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296282	39296282	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:39296282G>T	ENST00000345847.4	-	1	457	c.458C>A	c.(457-459)tCt>tAt	p.S153Y		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	149	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ttcacagcaagaggggcggca	0.662000													4	35					0.00909568	0.0096488	0.009096	1	0
SHOC2	8036	broad.mit.edu	37	10	112724437	112724437	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:112724437A>T	ENST00000369452.4	+	2	666	c.321A>T	c.(319-321)ttA>ttT	p.L107F	SHOC2_ENST00000265277.5_Missense_Mutation_p.L107F|SHOC2_ENST00000489390.1_Intron	NM_007373.3	NP_031399.2	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog (C. elegans)	107					fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(2)	17				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		GTTTGGACTTATCCAAGAGAT	0.408000													26	170					0	0	0.108266	0	0
FRMPD3	84443	broad.mit.edu	37	X	106845567	106845567	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:106845567C>G	ENST00000276185.4	+	16	4397	c.4397C>G	c.(4396-4398)cCc>cGc	p.P1466R				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1466						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GCAAGCCTCCCCATAGCCTTG	0.637000													6	30					0	0	0.058154	0	0
PTPRE	5791	broad.mit.edu	37	10	129868648	129868648	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:129868648G>T	ENST00000254667.3	+	14	1506	c.1227G>T	c.(1225-1227)aaG>aaT	p.K409N	PTPRE_ENST00000419012.2_Missense_Mutation_p.K409N|PTPRE_ENST00000306042.5_Missense_Mutation_p.K351N	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	409					negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CCCTGGAGAAGCACCTGCAGA	0.587000													12	82					1.3612e-06	1.60082e-06	0.132662	1	0
TRIM33	51592	broad.mit.edu	37	1	114952807	114952807	+	Splice_Site	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:114952807T>A	ENST00000358465.2	-	12	2276	c.2194_splice	c.e12+1	p.S731_splice	TRIM33_ENST00000450349.2_Splice_Site_p.S363_splice|TRIM33_ENST00000369543.2_Splice_Site_p.S731_splice	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	731					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGCTTTACCTGATGATCCCG	0.423000			T	RET	papillary thyroid								16	92					0	0	0.043863	0	0
RASSF2	9770	broad.mit.edu	37	20	4771116	4771116	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr20:4771116C>A	ENST00000379400.3	-	7	713	c.518G>T	c.(517-519)gGc>gTc	p.G173V	RASSF2_ENST00000478553.1_5'UTR|RASSF2_ENST00000379376.2_Missense_Mutation_p.G173V	NM_014737.2	NP_055552.1	P50749	RASF2_HUMAN	Ras association (RalGDS/AF-6) domain family member 2	173					cell cycle|signal transduction	nucleus	protein binding	p.G173V(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|pancreas(2)|prostate(2)|skin(2)	34						GTAGAAATGGCCGTTGATGGA	0.597000													11	15					2.27111e-07	2.7428e-07	0.093190	1	0
DZIP3	9666	broad.mit.edu	37	3	108344739	108344739	+	Silent	SNP	C	C	A	rs140722866		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:108344739C>A	ENST00000361582.3	+	7	734	c.504C>A	c.(502-504)atC>atA	p.I168I	DZIP3_ENST00000463306.1_Silent_p.I168I	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	168					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						AGATGATGATCCAAGAAAATG	0.308000													17	59					2.48551e-13	3.45331e-13	0.033300	1	0
FAM83B	222584	broad.mit.edu	37	6	54806246	54806246	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:54806246C>A	ENST00000306858.7	+	5	2593	c.2477C>A	c.(2476-2478)tCa>tAa	p.S826*		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	826										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AAAGTTGATTCATCTCCTAGA	0.383000													3	47					0.115264	0.118277	0.115264	1	0
NAGA	4668	broad.mit.edu	37	22	42464516	42464516	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr22:42464516G>C	ENST00000396398.3	-	2	611	c.79C>G	c.(79-81)Ccc>Gcc	p.P27A	NAGA_ENST00000402937.1_Missense_Mutation_p.P27A|NAGA_ENST00000403363.1_Missense_Mutation_p.P27A	NM_000262.2	NP_000253.1	P17050	NAGAB_HUMAN	N-acetylgalactosaminidase, alpha-	27					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						CAGCCCATGGGTGGTGTCTGC	0.567000													17	22					0	0	0.069288	0	0
TRPC1	7220	broad.mit.edu	37	3	142499778	142499778	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:142499778G>T	ENST00000273482.6	+	5	1156	c.765G>T	c.(763-765)acG>acT	p.T255T	TRPC1_ENST00000476941.1_Silent_p.T289T	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	289					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						TAAACCATACGTCTAGTGACG	0.378000													11	50					1.05317e-09	1.37218e-09	0.119110	1	0
DNMT3B	1789	broad.mit.edu	37	20	31368194	31368194	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr20:31368194T>C	ENST00000328111.2	+	2	386	c.65T>C	c.(64-66)cTc>cCc	p.L22P	DNMT3B_ENST00000348286.2_Missense_Mutation_p.L22P|DNMT3B_ENST00000375623.4_Missense_Mutation_p.L22P|DNMT3B_ENST00000201963.3_Missense_Mutation_p.L34P|DNMT3B_ENST00000443239.3_Missense_Mutation_p.L22P|DNMT3B_ENST00000456297.2_Missense_Mutation_p.L22P|DNMT3B_ENST00000353855.2_Missense_Mutation_p.L22P|DNMT3B_ENST00000344505.4_Missense_Mutation_p.L22P	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	22	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GACTCGATCCTCGTCAACGGG	0.642000													6	11					0	0	0.038147	0	0
HK3	3101	broad.mit.edu	37	5	176310847	176310847	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:176310847G>A	ENST00000292432.5	-	15	2068	c.1977C>T	c.(1975-1977)gcC>gcT	p.A659A		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	659	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATTGACAATGGCAACCACAT	0.572000													9	17					0	0	0.105934	0	0
SEMA3A	10371	broad.mit.edu	37	7	83592525	83592525	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:83592525T>A	ENST00000265362.3	-	16	2170	c.1856A>T	c.(1855-1857)gAa>gTa	p.E619V	SEMA3A_ENST00000436949.1_Missense_Mutation_p.E619V	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	619	Ig-like C2-type.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CTGTACCTCTTCTTTTCGCTC	0.393000													49	152					0	0	0.139131	0	0
PRSS58	136541	broad.mit.edu	37	7	141955425	141955425	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:141955425C>A	ENST00000552471.1	-	2	428	c.109G>T	c.(109-111)Gac>Tac	p.D37Y	PRSS58_ENST00000547058.2_Missense_Mutation_p.D37Y			Q8IYP2	PRS58_HUMAN	protease, serine, 58	37	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						GGCAAGTAGTCAGATTTCAAA	0.473000													74	68					2.17402e-21	3.28193e-21	0.139131	1	0
TP53	7157	broad.mit.edu	37	17	7577518	7577518	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:7577518T>A	ENST00000420246.2	-	7	895	c.763A>T	c.(763-765)Atc>Ttc	p.I255F	TP53_ENST00000445888.2_Missense_Mutation_p.I255F|TP53_ENST00000269305.4_Missense_Mutation_p.I255F|TP53_ENST00000413465.2_Missense_Mutation_p.I255F|TP53_ENST00000455263.2_Missense_Mutation_p.I255F|TP53_ENST00000359597.4_Missense_Mutation_p.I255F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	255	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		I -> F (in sporadic cancers; somatic mutation).|I -> M (in sporadic cancers; somatic mutation).|I -> N (in sporadic cancers; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I255F(20)|p.0?(8)|p.I255del(7)|p.I255fs*9(3)|p.I255V(3)|p.T253_I255del(2)|p.I255fs*8(1)|p.?(1)|p.I254fs*7(1)|p.I254_T256del(1)|p.R249_T256delRPILTIIT(1)|p.I255fs*90(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCAGTGTGATGATGGTGAGG	0.582000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	41					0	0	0.132662	0	0
THRA	7067	broad.mit.edu	37	17	38245627	38245627	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:38245627G>T	ENST00000450525.2	+	9	1642	c.1151G>T	c.(1150-1152)cGc>cTc	p.R384L	THRA_ENST00000584985.1_Intron|THRA_ENST00000394121.4_Intron|THRA_ENST00000264637.4_Intron|THRA_ENST00000546243.1_Missense_Mutation_p.R384L	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	451					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	CACGCCAGCCGCTTCCTCCAC	0.587000													8	22					3.8784e-16	5.74443e-16	0.062417	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51918646	51918646	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:51918646G>T	ENST00000353836.5	-	7	1340	c.1119C>A	c.(1117-1119)ggC>ggA	p.G373G	SIGLEC10_ENST00000439889.2_Silent_p.G315G|SIGLEC10_ENST00000432469.2_Silent_p.G290G|SIGLEC10_ENST00000356298.5_Silent_p.G373G|SIGLEC10_ENST00000442846.3_Silent_p.G225G|SIGLEC10_ENST00000441969.3_Silent_p.G315G|SIGLEC10_ENST00000339313.5_Silent_p.G373G|SIGLEC10_ENST00000436984.2_Silent_p.G325G|SIGLEC10_ENST00000525998.1_Silent_p.G283G	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	373	Ig-like C2-type 3.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		ACAGGCTTTGGCCCTCCAGTA	0.627000													7	45					7.48243e-07	8.86597e-07	0.058154	1	0
CPA1	1357	broad.mit.edu	37	7	130020972	130020972	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:130020972G>A	ENST00000011292.3	+	2	249	c.99G>A	c.(97-99)gaG>gaA	p.E33E	CPA1_ENST00000484324.1_5'UTR	NM_001868.2	NP_001859.1	P15085	CBPA1_HUMAN	carboxypeptidase A1 (pancreatic)	33					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(18;0.0435)					TAGCCGATGAGGCCCAGGTAC	0.637000													6	18					0	0	0.047766	0	0
CSMD1	64478	broad.mit.edu	37	8	3047572	3047572	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:3047572C>A	ENST00000520002.1	-	35	5818	c.5263G>T	c.(5263-5265)Ggt>Tgt	p.G1755C	CSMD1_ENST00000542608.1_Missense_Mutation_p.G1754C|CSMD1_ENST00000539096.1_Missense_Mutation_p.G1754C|CSMD1_ENST00000537824.1_Missense_Mutation_p.G1754C|CSMD1_ENST00000400186.3_Missense_Mutation_p.G1755C|CSMD1_ENST00000602723.1_Missense_Mutation_p.G1755C|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602557.1_Missense_Mutation_p.G1755C			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1755	Sushi 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AACTCAGAACCAATTCTCCTT	0.572000													4	9					1.23904e-05	1.40963e-05	0.014758	1	0
PCDHB17P	54661	broad.mit.edu	37	5	140536976	140536976	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140536976C>A	ENST00000539533.1	+	1	1400	c.1400C>A	c.(1399-1401)cCc>cAc	p.P467H																								AACAACAGCCCCGCCCTGCAC	0.632000													29	86					2.48909e-17	3.72178e-17	0.139131	1	0
F11R	50848	broad.mit.edu	37	1	160970066	160970066	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:160970066G>A	ENST00000368026.6	-	5	735	c.461C>T	c.(460-462)tCa>tTa	p.S154L	F11R_ENST00000289779.3_3'UTR|F11R_ENST00000472573.1_5'UTR|F11R_ENST00000537746.1_Missense_Mutation_p.S105L	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	154	Ig-like V-type 2.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			ATCTTGTTCTGAGCATGTCAG	0.522000													9	57					0	0	0.093190	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812895	31812895	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:31812895T>A	ENST00000334067.3	+	1	299	c.250T>A	c.(250-252)Tgc>Agc	p.C84S		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	84						intermediate filament				kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						TTCCATCTTCTGCAGTCCCCG	0.517000													57	121					0	0	0.139131	0	0
SSH2	85464	broad.mit.edu	37	17	28004720	28004720	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:28004720G>A	ENST00000269033.3	-	6	589	c.438C>T	c.(436-438)agC>agT	p.S146S	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Silent_p.S173S|SSH2_ENST00000324677.7_5'UTR	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	146					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTAGCGTGTCGCTCCAGAGAG	0.443000													25	92					0	0	0.045705	0	0
H2BFM	286436	broad.mit.edu	37	X	103294617	103294617	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:103294617C>A	ENST00000243297.5	+	3	383	c.383C>A	c.(382-384)cCc>cAc	p.P128H	H2BFM_ENST00000355016.3_Missense_Mutation_p.P25H					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						ATCCAGGAGCCCAAAGAGGCC	0.637000													3	11					0.115264	0.118277	0.115264	1	0
OR4N4	283694	broad.mit.edu	37	15	22382663	22382663	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:22382663G>T	ENST00000328795.4	+	1	282	c.191G>T	c.(190-192)gGc>gTc	p.G64V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTATTTCTGGGCAACTTGGCC	0.463000													21	254					1.90571e-15	2.78322e-15	0.069456	1	0
TRIM33	51592	broad.mit.edu	37	1	114952806	114952806	+	Splice_Site	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:114952806C>A	ENST00000358465.2	-	12	2277	c.2194_splice	c.e12+1	p.G732_splice	TRIM33_ENST00000450349.2_Splice_Site_p.G364_splice|TRIM33_ENST00000369543.2_Splice_Site_p.G732_splice	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	732					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGCTTTACCTGATGATCCC	0.428000			T	RET	papillary thyroid								16	92					2.94398e-08	3.71249e-08	0.043863	1	0
AVL9	23080	broad.mit.edu	37	7	32609734	32609734	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:32609734C>A	ENST00000318709.4	+	11	1539	c.1318C>A	c.(1318-1320)Caa>Aaa	p.Q440K	AVL9_ENST00000404479.1_Intron|AVL9_ENST00000409301.1_Missense_Mutation_p.Q440K	NM_015060.1	NP_055875.1	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	440						integral to membrane				endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CCTTTTTCGACAACAGAAACA	0.443000													19	108					1.00905e-13	1.41447e-13	0.049695	1	0
EPHA7	2045	broad.mit.edu	37	6	93956625	93956625	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:93956625C>T	ENST00000369303.4	-	15	2795	c.2611G>A	c.(2611-2613)Gat>Aat	p.D871N		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	871	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGCCAACAATCCAACATTAGC	0.418000													16	62					0	0	0.033300	0	0
RYR2	6262	broad.mit.edu	37	1	237586495	237586495	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:237586495G>C	ENST00000366574.2	+	12	1269	c.952G>C	c.(952-954)Gac>Cac	p.D318H	RYR2_ENST00000360064.6_Missense_Mutation_p.D316H|RYR2_ENST00000542537.1_Missense_Mutation_p.D302H	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	318	MIR 4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTACTCATGGACAAAGAGAA	0.423000													16	65					0	0	0.146539	0	0
ABI3BP	25890	broad.mit.edu	37	3	100568898	100568898	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:100568898T>A	ENST00000471714.1	-	17	1622	c.1513A>T	c.(1513-1515)Acg>Tcg	p.T505S	ABI3BP_ENST00000495063.1_Missense_Mutation_p.T505S|ABI3BP_ENST00000284322.5_Missense_Mutation_p.T456S			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	456	Pro-rich.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						CCAGGTGTCGTAGGCTGCATT	0.383000													6	26					0	0	0.038147	0	0
LGALS13	29124	broad.mit.edu	37	19	40095876	40095876	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:40095876G>T	ENST00000221797.4	+	3	196	c.151G>T	c.(151-153)Gcc>Tcc	p.A51S		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	51	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TTCAGATATTGCCTTCCGTTT	0.507000													16	66					0.000566183	0.000619448	0.033300	1	0
SPAG17	200162	broad.mit.edu	37	1	118565977	118565977	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:118565977G>T	ENST00000336338.5	-	28	4084	c.4019C>A	c.(4018-4020)tCt>tAt	p.S1340Y		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1340						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTCTGCTGAGAAATAGAGTC	0.423000													14	90					9.16793e-09	1.16078e-08	0.033300	1	0
C4BPA	722	broad.mit.edu	37	1	207286344	207286344	+	Splice_Site	SNP	A	A	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:207286344A>C	ENST00000367070.3	+	2	169		c.e2-1			NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha						complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TTCTTTCAGCAGAAAAACATC	0.428000													24	93					0	0	0.125774	0	0
BRCA2	675	broad.mit.edu	37	13	32906434	32906434	+	Silent	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:32906434A>T	ENST00000544455.1	+	10	1046	c.819A>T	c.(817-819)tcA>tcT	p.S273S	BRCA2_ENST00000380152.3_Silent_p.S273S	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	273					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAGGGAATTCATTTAAAGTAA	0.303000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			7	23					0	0	0.047766	0	0
CLMN	79789	broad.mit.edu	37	14	95682072	95682072	+	Splice_Site	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:95682072T>A	ENST00000298912.4	-	5	438		c.e5-2			NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)							integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		CAGTTTTACCTGGAGGGAAGC	0.433000													6	14					0	0	0.038147	0	0
ASCC2	84164	broad.mit.edu	37	22	30197038	30197038	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr22:30197038C>A	ENST00000397771.2	-	16	1807	c.1630G>T	c.(1630-1632)Gag>Tag	p.E544*	ASCC2_ENST00000542393.1_Nonsense_Mutation_p.E468*|ASCC2_ENST00000307790.3_Nonsense_Mutation_p.E544*			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	544					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			ACATCAAACTCGTCATTCTGG	0.567000													4	142					0.014758	0.0156027	0.014758	1	0
IGSF21	84966	broad.mit.edu	37	1	18692124	18692124	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:18692124G>T	ENST00000251296.1	+	6	1331	c.948G>T	c.(946-948)gaG>gaT	p.E316D		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	316						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		TCGACAACGAGGCCCTCTTCA	0.632000													25	97					9.65021e-13	1.32322e-12	0.045705	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102505474	102505474	+	Silent	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:102505474C>T	ENST00000360184.4	+	60	11507	c.11343C>T	c.(11341-11343)acC>acT	p.T3781T	RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3781	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CAGAGGTCACCAGGAAAGTTG	0.547000													14	27					0	0	0.146539	0	0
FLG	2312	broad.mit.edu	37	1	152285700	152285700	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:152285700C>A	ENST00000368799.1	-	3	1697	c.1662G>T	c.(1660-1662)agG>agT	p.R554S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	554	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGCATCAGACCTTCCCTGGG	0.562000									Ichthyosis				45	177					5.82218e-30	9.14082e-30	0.139131	1	0
AK2	204	broad.mit.edu	37	1	33478834	33478834	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:33478834A>G	ENST00000373449.2	-	6	709	c.668T>C	c.(667-669)aTc>aCc	p.I223T	AK2_ENST00000480134.1_3'UTR|RP1-117O3.2_ENST00000427524.1_RNA|AK2_ENST00000354858.6_Missense_Mutation_p.I223T|AK2_ENST00000467905.1_Missense_Mutation_p.I223T|AK2_ENST00000548033.1_Missense_Mutation_p.I181T|AK2_ENST00000491241.1_5'UTR	NM_001199199.1|NM_013411.4	NP_001186128.1|NP_037543.1	P54819	KAD2_HUMAN	adenylate kinase 2	223					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GGCTGCTAGGATGCTTGCGAA	0.498000													3	89					0	0	0.047766	0	0
WWC3	55841	broad.mit.edu	37	X	10109476	10109476	+	Splice_Site	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:10109476G>C	ENST00000380861.4	+	23	3605	c.3212_splice	c.e23-1	p.E1072_splice	WWC3_ENST00000454666.1_Splice_Site_p.E1072_splice	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	1072										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CGGTCCCAGGGAGAAGATAGC	0.463000													9	54					0	0	0.058154	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56703226	56703226	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:56703226C>A	ENST00000586855.2	-	3	894	c.581G>T	c.(580-582)aGg>aTg	p.R194M	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.R194M			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	194					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CACCTGCCTCCTGGACAGTGC	0.612000													5	44					0.000274275	0.000302184	0.047766	1	0
KRT4	3851	broad.mit.edu	37	12	53205732	53205732	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:53205732G>T	ENST00000551956.1	-	2	984	c.492C>A	c.(490-492)gtC>gtA	p.V164V	KRT4_ENST00000458244.2_Silent_p.V144V|KRT4_ENST00000293774.4_Silent_p.V238V			B4DRS2	B4DRS2_HUMAN	keratin 4	164						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						TGGTCTCCAGGACCTTATTCT	0.547000													10	20					3.86212e-05	4.33109e-05	0.069234	1	0
LOC644669	644669	broad.mit.edu	37	18	15316704	15316704	+	RNA	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:15316704G>T	ENST00000455308.2	-	0	719					NR_027417.1																						GCTTTCAGCCGTGTCAGGTGT	0.423000													5	19					0.00116845	0.0012608	0.021553	1	0
RHOH	399	broad.mit.edu	37	4	40245314	40245314	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:40245314G>C	ENST00000381799.4	+	3	1032	c.308G>C	c.(307-309)aGg>aCg	p.R103T	RHOH_ENST00000505618.1_Missense_Mutation_p.R103T	NM_001278363.1|NM_001278365.1|NM_004310.3	NP_001265292.1|NP_001265294.1|NP_004301.1	Q15669	RHOH_HUMAN	ras homolog family member H	103					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			kidney(1)|large_intestine(3)|lung(7)|ovary(1)	12						GGTGAAATTAGGAGCAACTTG	0.577000													19	44					0	0	0.038395	0	0
TG	7038	broad.mit.edu	37	8	133906050	133906050	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:133906050G>A	ENST00000220616.4	+	11	2917	c.2877G>A	c.(2875-2877)gtG>gtA	p.V959V	TG_ENST00000377869.1_Silent_p.V959V	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	959	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTTTCCTGGTGGCCAAGGGAA	0.572000													67	119					0	0	0.139131	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553933	140553933	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140553933T>A	ENST00000231137.3	+	1	1691	c.1517T>A	c.(1516-1518)aTc>aAc	p.I506N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		506	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGTCTCCATCAACGCGGAC	0.687000													13	36					0	0	0.033300	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185705	127185705	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:127185705C>A	ENST00000371124.3	-	1	677	c.481G>T	c.(481-483)Ggg>Tgg	p.G161W		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	161						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CAAGTGACCCCATCTCCACTG	0.572000													95	263					1.72158e-54	2.80092e-54	0.139131	1	0
MMP21	118856	broad.mit.edu	37	10	127464357	127464357	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:127464357G>T	ENST00000368808.3	-	1	33	c.34C>A	c.(34-36)Ctg>Atg	p.L12M		NM_147191.1	NP_671724.1	Q8N119	MMP21_HUMAN	matrix metallopeptidase 21	12					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	16		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CAGCAGAGCAGCAGTGTCGGA	0.677000													4	51					5.18039e-06	6.00237e-06	0.038147	1	0
CBL	867	broad.mit.edu	37	11	119145632	119145632	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:119145632C>T	ENST00000264033.4	+	5	1214	c.838C>T	c.(838-840)Cgg>Tgg	p.R280W		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	280	Cbl-PTB.|SH2-like.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		AGTGAAAGCTCGGCTCCAGAA	0.428000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				10	61					0	0	0.119110	0	0
CEP170	9859	broad.mit.edu	37	1	243362479	243362479	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:243362479G>A	ENST00000366542.1	-	7	565	c.514C>T	c.(514-516)Cgt>Tgt	p.R172C	CEP170_ENST00000366543.1_Missense_Mutation_p.R172C|CEP170_ENST00000366544.1_Missense_Mutation_p.R172C	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	172						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GGAGTACCACGGGGCATAGCA	0.433000													6	27					0	0	0.047766	0	0
KRAS	3845	broad.mit.edu	37	12	25398282	25398282	+	Missense_Mutation	SNP	C	C	A	rs121913535		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:25398282C>A	ENST00000311936.3	-	2	228	c.37G>T	c.(37-39)Ggc>Tgc	p.G13C	KRAS_ENST00000557334.1_Missense_Mutation_p.G13C|KRAS_ENST00000556131.1_Missense_Mutation_p.G13C|KRAS_ENST00000256078.4_Missense_Mutation_p.G13C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	13			G -> D (in a breast carcinoma cell line and GASC; somatic mutation).|G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13C(213)|p.G13S(59)|p.G13R(43)|p.G12_G13insG(3)|p.G13N(1)|p.G13I(1)|p.G12_G13insA(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TTGCCTACGCCACCAGCTCCA	0.343000	G13C(MORCPR_LUNG)|G13C(NCIH1355_LUNG)|G13C(NCIH1734_LUNG)|G13C(TOV21G_OVARY)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	8					0.0477658	0.0499948	0.047766	1	0
ZDHHC18	84243	broad.mit.edu	37	1	27176877	27176877	+	Silent	SNP	C	C	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:27176877C>G	ENST00000374142.3	+	4	827	c.732C>G	c.(730-732)ctC>ctG	p.L244L		NM_032283.2	NP_115659.1	Q9NUE0	ZDH18_HUMAN	zinc finger, DHHC-type containing 18	244						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(2)	3		all_cancers(24;5.82e-22)|all_epithelial(13;9.91e-20)|Colorectal(325;0.000147)|Breast(348;0.000706)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;5.71e-53)|Epithelial(14;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(117;1.53e-29)|Colorectal(126;1.9e-09)|COAD - Colon adenocarcinoma(152;4.2e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000548)|STAD - Stomach adenocarcinoma(196;0.00065)|KIRC - Kidney renal clear cell carcinoma(1967;0.000779)|GBM - Glioblastoma multiforme(114;0.0265)|READ - Rectum adenocarcinoma(331;0.0455)|Lung(427;0.163)|LUSC - Lung squamous cell carcinoma(448;0.237)		TTCTCTCCCTCTCATTCCTGA	0.572000													4	33					0	0	0.014758	0	0
ROR2	4920	broad.mit.edu	37	9	94486414	94486414	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:94486414C>A	ENST00000375708.3	-	9	2560	c.2362G>T	c.(2362-2364)Ggg>Tgg	p.G788W	ROR2_ENST00000375715.1_Intron|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	788	Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.G788W(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TGCTTGGGCCCCACGTAGCGG	0.667000													20	41					1.64293e-13	2.2928e-13	0.083992	1	0
ITK	3702	broad.mit.edu	37	5	156608054	156608054	+	Silent	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:156608054T>C	ENST00000422843.3	+	1	218	c.66T>C	c.(64-66)tcT>tcC	p.S22S		NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	22	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAAGAACTTCTCCCTCGAACT	0.428000			T	SYK	peripheral T-cell lymphoma								13	66					0	0	0.093190	0	0
ACOT12	134526	broad.mit.edu	37	5	80626271	80626271	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:80626271G>T	ENST00000307624.3	-	15	1638	c.1610C>A	c.(1609-1611)gCc>gAc	p.A537D	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	537	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TATACAAGAGGCTGCTGTTTC	0.368000													20	28					5.26018e-13	7.24428e-13	0.062417	1	0
USH2A	7399	broad.mit.edu	37	1	216256892	216256892	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:216256892C>A	ENST00000366943.2	-	26	5590	c.5204G>T	c.(5203-5205)gGa>gTa	p.G1735V	RP11-22M7.2_ENST00000430890.1_RNA|RP11-22M7.2_ENST00000442606.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.G1735V|RP11-22M7.2_ENST00000446411.1_RNA|RP11-22M7.2_ENST00000445619.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1735	Laminin G-like 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAAGTTCATTCCACCATGAAA	0.333000										HNSCC(13;0.011)			33	128					3.11337e-16	4.63317e-16	0.054565	1	0
TP53TG5	27296	broad.mit.edu	37	20	44004176	44004176	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr20:44004176T>A	ENST00000372726.3	-	4	427	c.271A>T	c.(271-273)Aat>Tat	p.N91Y	TP53TG5_ENST00000537995.1_Missense_Mutation_p.N75Y|SYS1-DBNDD2_ENST00000452133.1_Intron|TP53TG5_ENST00000494455.1_5'UTR|SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1_ENST00000426004.1_3'UTR	NM_014477.2	NP_055292.1	Q9Y2B4	T53G5_HUMAN	TP53 target 5	91					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	12						TTTGTTTTATTGCAGGCACTG	0.507000													13	38					0	0	0.093190	0	0
TRAT1	50852	broad.mit.edu	37	3	108572676	108572676	+	Silent	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:108572676C>T	ENST00000295756.6	+	6	743	c.513C>T	c.(511-513)ccC>ccT	p.P171P	TRAT1_ENST00000426646.1_Silent_p.P134P	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	171					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						ATGATGATCCCATCAGACTGT	0.428000													31	78					0	0	0.059317	0	0
HOXB1	3211	broad.mit.edu	37	17	46606949	46606949	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:46606949C>A	ENST00000239174.6	-	2	958	c.866G>T	c.(865-867)tGc>tTc	p.C289F	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	289						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CGGGGAGGTGCATGTCGACTG	0.642000													15	38					1.99824e-07	2.45096e-07	0.033300	1	0
RSRC1	51319	broad.mit.edu	37	3	157920997	157920997	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:157920997A>T	ENST00000295930.3	+	4	619	c.457A>T	c.(457-459)Aaa>Taa	p.K153*	RSRC1_ENST00000464171.1_Intron|RSRC1_ENST00000312179.6_Intron|RSRC1_ENST00000496268.1_3'UTR|RSRC1_ENST00000480820.1_Nonsense_Mutation_p.K153*|RSRC1_ENST00000475278.2_Nonsense_Mutation_p.K153*	NM_001271838.1|NM_016625.2	NP_001258767.1|NP_057709.2	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	153					nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			ggagaaggataaagggaagga	0.433000													14	31					0	0	0.146539	0	0
CCNG1	900	broad.mit.edu	37	5	162869132	162869132	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:162869132C>T	ENST00000340828.2	+	5	903	c.679C>T	c.(679-681)Ctt>Ttt	p.L227F	CCNG1_ENST00000512163.1_Missense_Mutation_p.L93F|CCNG1_ENST00000510664.1_Missense_Mutation_p.L99F|AC112205.1_ENST00000599797.1_Intron|CCNG1_ENST00000393929.1_Missense_Mutation_p.L227F|CCNG1_ENST00000504553.1_Missense_Mutation_p.L93F|CCNG1_ENST00000511683.2_Missense_Mutation_p.L93F	NM_004060.3	NP_004051.1	P51959	CCNG1_HUMAN	cyclin G1	227					cell division|mitosis|regulation of cyclin-dependent protein kinase activity	nucleus		p.L227F(1)		autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0597)|OV - Ovarian serous cystadenocarcinoma(192;0.107)|Epithelial(171;0.164)		AATAGAATGTCTTCAGAAACA	0.358000													8	39					0	0	0.058154	0	0
SLC6A8	6535	broad.mit.edu	37	X	152956967	152956967	+	Missense_Mutation	SNP	C	C	G	rs143019641	byFrequency	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:152956967C>G	ENST00000253122.5	+	3	1079	c.603C>G	c.(601-603)gaC>gaG	p.D201E	SLC6A8_ENST00000430077.2_Missense_Mutation_p.D86E	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	201					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	TCACCTGTGACCAGCTTGCTG	0.632000													9	30					0	0	0.119110	0	0
CD300LG	146894	broad.mit.edu	37	17	41926251	41926251	+	Silent	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:41926251C>T	ENST00000317310.4	+	2	410	c.369C>T	c.(367-369)ttC>ttT	p.F123F	CD300LG_ENST00000588884.1_Silent_p.F123F|CD300LG_ENST00000586233.1_Silent_p.F123F|CD300LG_ENST00000539718.1_Silent_p.F123F|CD300LG_ENST00000377203.4_Silent_p.F123F|CD300LG_ENST00000293396.8_Silent_p.F123F	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g	123						apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity			central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCTCTCTGTTCGTCTTTCCAG	0.557000													7	26					0	0	0.029380	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20873760	20873760	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:20873760G>A	ENST00000324344.3	-	2	386	c.101C>T	c.(100-102)gCa>gTa	p.A34V	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.A34V|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	34					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		ACGGTGGCCTGCACCCCTCCT	0.597000													62	210					0	0	0.139131	0	0
KIAA0556	23247	broad.mit.edu	37	16	27788315	27788315	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:27788315G>C	ENST00000261588.4	+	25	4535	c.4516G>C	c.(4516-4518)Gcg>Ccg	p.A1506P		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1506										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GTGGAATTATGCGAAAACACC	0.448000													20	83					0	0	0.083992	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666503	50666503	+	Missense_Mutation	SNP	C	C	A	rs116030028	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:50666503C>A	ENST00000371821.1	+	7	1126	c.811C>A	c.(811-813)Cct>Act	p.P271T	ELAVL4_ENST00000371827.1_Intron|ELAVL4_ENST00000371819.1_Intron|ELAVL4_ENST00000357083.4_Intron|ELAVL4_ENST00000371823.4_Missense_Mutation_p.P266T|ELAVL4_ENST00000448907.2_Intron|ELAVL4_ENST00000371824.1_Intron			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	266					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						ACCAGTCCCCCCTTCTGCTTG	0.527000													24	186					9.95505e-16	1.46069e-15	0.069288	1	0
PTCHD4	442213	broad.mit.edu	37	6	47846929	47846929	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:47846929C>A	ENST00000339488.4	-	3	1684	c.1651G>T	c.(1651-1653)Gtg>Ttg	p.V551L		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	551						integral to membrane	hedgehog receptor activity										TACTGCTCCACCCAGGACACT	0.463000													18	18					3.62473e-10	4.74236e-10	0.062417	1	0
FBN2	2201	broad.mit.edu	37	5	127686693	127686693	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:127686693G>C	ENST00000508053.1	-	27	3653	c.2679C>G	c.(2677-2679)agC>agG	p.S893R	FBN2_ENST00000508989.1_Missense_Mutation_p.S860R|FBN2_ENST00000262464.4_Missense_Mutation_p.S893R			P35556	FBN2_HUMAN	fibrillin 2	893					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCCCCTTCAGGCTGTCTGAAA	0.468000													19	59					0	0	0.083992	0	0
RBMX	27316	broad.mit.edu	37	X	135956613	135956613	+	Splice_Site	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:135956613T>A	ENST00000320676.7	-	9	1020		c.e9-2		RBMX_ENST00000431446.3_Intron|RBMX_ENST00000570135.1_Splice_Site|RBMX_ENST00000565438.1_Splice_Site|RBMX_ENST00000562646.1_3'UTR	NM_002139.3	NP_002130.2	P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked							catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|urinary_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					GTGAGTTACCTGCAGGGTCAA	0.413000													17	61					0	0	0.069288	0	0
MTMR6	9107	broad.mit.edu	37	13	25835922	25835922	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:25835922T>A	ENST00000381801.5	-	6	1371	c.610A>T	c.(610-612)Agt>Tgt	p.S204C	MTMR6_ENST00000540661.1_Missense_Mutation_p.S204C|MTMR6_ENST00000482345.1_5'UTR	NM_004685.3	NP_004676.3	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	204	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		AGTGGCTGACTACATCGACAA	0.388000													9	12					0	0	0.047766	0	0
KIAA0020	9933	broad.mit.edu	37	9	2820023	2820023	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:2820023T>C	ENST00000397885.2	-	13	1470	c.1264A>G	c.(1264-1266)Ata>Gta	p.I422V		NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	422	PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		CTTACTGATATGATTATCTGC	0.388000													8	70					0	0	0.038147	0	0
YIPF7	285525	broad.mit.edu	37	4	44638008	44638008	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:44638008A>G	ENST00000332990.5	-	3	299	c.283T>C	c.(283-285)Tcc>Ccc	p.S95P		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	95						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						TCTGAGTTGGATGCTGGCTGA	0.418000													21	73					0	0	0.069288	0	0
COL24A1	255631	broad.mit.edu	37	1	86304322	86304322	+	Splice_Site	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:86304322C>T	ENST00000370571.2	-	43	3994		c.e43-1		COL24A1_ENST00000436319.1_Splice_Site	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1						cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CCACTGGACCCTACAGAGACC	0.398000													39	156					0	0	0.124865	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554452	140554452	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140554452A>T	ENST00000231137.3	+	1	2210	c.2036A>T	c.(2035-2037)gAc>gTc	p.D679V		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		679					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCCCCGGACCAGGCCAAC	0.701000													10	170					0	0	0.080935	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018911	14018911	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:14018911G>A	ENST00000279593.3	-	2	441	c.232C>T	c.(232-234)Cca>Tca	p.P78S		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	78					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCTCTTTGGGTCGGTCTCA	0.552000													75	99					0	0	0.139131	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526298	176526298	+	Silent	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:176526298T>A	ENST00000367662.3	+	2	2004	c.840T>A	c.(838-840)gcT>gcA	p.A280A	PAPPA2_ENST00000367661.3_Silent_p.A280A	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	280					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AAGTGCTGGCTGAGATTCCCC	0.582000													14	67					0	0	0.033300	0	0
OR8U1	219417	broad.mit.edu	37	11	56143746	56143746	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:56143746T>A	ENST00000302270.1	+	1	647	c.647T>A	c.(646-648)gTc>gAc	p.V216D		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					ATTGTCTTTGTCTCCTACATG	0.498000													21	87					0	0	0.055883	0	0
UNC80	285175	broad.mit.edu	37	2	210858055	210858055	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:210858055T>G	ENST00000439458.1	+	62	9295	c.9215T>G	c.(9214-9216)cTa>cGa	p.L3072R	UNC80_ENST00000272845.5_Missense_Mutation_p.L3048R	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	3072						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						CGTCCTCTACTATCACGTCAG	0.453000													3	10					0	0	0.115264	0	0
LRFN5	145581	broad.mit.edu	37	14	42360493	42360493	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:42360493C>A	ENST00000298119.4	+	4	2615	c.1426C>A	c.(1426-1428)Ctg>Atg	p.L476M	LRFN5_ENST00000554171.1_Intron|LRFN5_ENST00000554120.1_Intron	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	476	Fibronectin type-III.					integral to membrane		p.L476V(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GGTCAATAATCTGGCTGCTGG	0.403000										HNSCC(30;0.082)			13	75					5.26018e-13	7.24428e-13	0.062417	1	0
ACBD5	91452	broad.mit.edu	37	10	27508756	27508756	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:27508756T>A	ENST00000396271.3	-	6	647	c.521A>T	c.(520-522)aAc>aTc	p.N174I	ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375897.3_Missense_Mutation_p.N65I|ACBD5_ENST00000375905.4_Missense_Mutation_p.N139I|ACBD5_ENST00000375888.1_Missense_Mutation_p.N183I|ACBD5_ENST00000375901.1_Missense_Mutation_p.N65I	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	183					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						GGTTTTGGCGTTTGGAGTAGA	0.388000													14	34					0	0	0.105934	0	0
NHLH2	4808	broad.mit.edu	37	1	116380682	116380682	+	Silent	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:116380682C>A	ENST00000369506.1	-	1	5856	c.312G>T	c.(310-312)ctG>ctT	p.L104L	NHLH2_ENST00000320238.3_Silent_p.L104L			Q02577	HEN2_HUMAN	nescient helix loop helix 2	104	Helix-loop-helix motif.				cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			prostate(1)	1	Lung SC(450;0.184)	all_cancers(81;1.75e-06)|all_epithelial(167;1.16e-06)|all_lung(203;9.55e-06)|Lung NSC(69;5.83e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GCAGCGTGGGCAGCAATTTGC	0.657000													6	17					0.0381472	0.040061	0.038147	1	0
FAM47A	158724	broad.mit.edu	37	X	34150181	34150181	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:34150181C>A	ENST00000346193.3	-	1	266	c.215G>T	c.(214-216)cGc>cTc	p.R72L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	72								p.R72H(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						CTCGTCACGGCGACAAACGAG	0.537000													48	140					4.17328e-34	6.61824e-34	0.139131	1	0
FYB	2533	broad.mit.edu	37	5	39202804	39202804	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:39202804C>A	ENST00000351578.6	-	2	449	c.259G>T	c.(259-261)Gga>Tga	p.G87*	FYB_ENST00000512982.1_Nonsense_Mutation_p.G87*|FYB_ENST00000540520.1_Nonsense_Mutation_p.G97*|FYB_ENST00000505428.1_Nonsense_Mutation_p.G87*|FYB_ENST00000515010.1_Nonsense_Mutation_p.G87*	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	87					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCCTGCTCCAGTGGGCTTT	0.542000													15	87					1.15088e-07	1.42836e-07	0.146539	1	0
CLCN4	1183	broad.mit.edu	37	X	10188801	10188801	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:10188801G>T	ENST00000380833.4	+	12	2467	c.2076G>T	c.(2074-2076)aaG>aaT	p.K692N	CLCN4_ENST00000380829.1_Missense_Mutation_p.K661N|CLCN4_ENST00000421085.2_Missense_Mutation_p.K598N	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	692						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ATCCCCTGAAGCTGCGGCGCA	0.592000													52	244					3.30712e-30	5.21827e-30	0.139131	1	0
ATP4A	495	broad.mit.edu	37	19	36050049	36050049	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:36050049G>A	ENST00000262623.3	-	8	1129	c.1101C>T	c.(1099-1101)tgC>tgT	p.C367C		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	367					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding	p.C367C(1)		breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TCTTGACCACGCAGTTCTTAC	0.617000													67	510					0	0	0.139131	0	0
EMC3	55831	broad.mit.edu	37	3	10049235	10049235	+	RNA	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:10049235G>T	ENST00000383808.2	-	0	763																											GAGGCCTGACGTAGGAGTGCT	0.587000													26	60					3.65163e-15	5.30839e-15	0.116897	1	0
DUSP27	92235	broad.mit.edu	37	1	167096156	167096156	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:167096156C>A	ENST00000361200.2	+	6	1954	c.1788C>A	c.(1786-1788)caC>caA	p.H596Q	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.H596Q|DUSP27_ENST00000271385.5_Missense_Mutation_p.H596Q			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	596					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGCTGAAACACCAGAAGAAGG	0.622000													11	37					0.00244969	0.00263426	0.119110	1	0
LPHN2	23266	broad.mit.edu	37	1	82436122	82436122	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:82436122G>T	ENST00000370728.1	+	18	3491	c.2846G>T	c.(2845-2847)aGg>aTg	p.R949M	LPHN2_ENST00000370717.2_Missense_Mutation_p.R949M|LPHN2_ENST00000271029.4_Missense_Mutation_p.R949M|LPHN2_ENST00000370730.1_Missense_Mutation_p.R949M|LPHN2_ENST00000370713.1_Missense_Mutation_p.R936M|LPHN2_ENST00000394879.1_Missense_Mutation_p.R936M|LPHN2_ENST00000335786.5_Missense_Mutation_p.R949M|LPHN2_ENST00000370727.1_Missense_Mutation_p.R949M|LPHN2_ENST00000319517.6_Missense_Mutation_p.R936M|LPHN2_ENST00000370723.1_Missense_Mutation_p.R936M|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370715.1_Missense_Mutation_p.R936M|LPHN2_ENST00000359929.3_Missense_Mutation_p.R936M|LPHN2_ENST00000370725.1_Missense_Mutation_p.R949M|LPHN2_ENST00000370721.1_Missense_Mutation_p.R874M			O95490	LPHN2_HUMAN	latrophilin 2	949					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GAATATTCAAGGAAAAAATAT	0.378000													8	27					0.00621372	0.00663642	0.058154	1	0
MAN1A2	10905	broad.mit.edu	37	1	118039517	118039517	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:118039517G>A	ENST00000356554.3	+	10	2152	c.1417G>A	c.(1417-1419)Gat>Aat	p.D473N		NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	473					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		ACTAGGAGCAGATGGTTCCAG	0.433000													29	93					0	0	0.144211	0	0
MORC4	79710	broad.mit.edu	37	X	106219857	106219857	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:106219857G>A	ENST00000355610.4	-	9	1388	c.1114C>T	c.(1114-1116)Cct>Tct	p.P372S	MORC4_ENST00000255495.7_Missense_Mutation_p.P372S|MORC4_ENST00000535534.1_Missense_Mutation_p.P120S	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	372							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						TTGTAGGCAGGTTTTAGGAAA	0.408000													35	165					0	0	0.098360	0	0
TMEM131	23505	broad.mit.edu	37	2	98475769	98475769	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:98475769T>C	ENST00000186436.5	-	5	709	c.481A>G	c.(481-483)Agg>Ggg	p.R161G	TMEM131_ENST00000425805.2_Missense_Mutation_p.R112G	NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	161						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AAACTTACCCTATTTTGAAAA	0.303000													46	54					0	0	0.139131	0	0
SATL1	340562	broad.mit.edu	37	X	84363384	84363384	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:84363384G>A	ENST00000509231.1	-	1	670	c.591C>T	c.(589-591)ggC>ggT	p.G197G	SATL1_ENST00000395409.3_Silent_p.G10G|SATL1_ENST00000332921.5_Silent_p.G10G			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	10	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GTTGTTGCACGCCTGGTTGCC	0.572000													24	78					0	0	0.083992	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869625	151869625	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:151869625C>A	ENST00000329342.5	+	3	540	c.315C>A	c.(313-315)ttC>ttA	p.F105L		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	105							protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCTGAGTTCCAAGCAGCAC	0.547000													22	114					1.10513e-12	1.50875e-12	0.069288	1	0
GTPBP2	54676	broad.mit.edu	37	6	43593175	43593175	+	Silent	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:43593175G>A	ENST00000307126.5	-	5	629	c.630C>T	c.(628-630)cgC>cgT	p.R210R	GTPBP2_ENST00000307114.7_Silent_p.R122R|GTPBP2_ENST00000476510.1_5'UTR	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	210							GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CATGCAGGTGGCGGAAAAGGT	0.582000													85	86					0	0	0.139131	0	0
LILRA2	11027	broad.mit.edu	37	19	55085904	55085904	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:55085904G>T	ENST00000251377.3	+	4	340	c.207G>T	c.(205-207)tgG>tgT	p.W69C	LILRA2_ENST00000251376.3_Missense_Mutation_p.W69C|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.W57C|LILRA2_ENST00000391738.3_Missense_Mutation_p.W69C|LILRA2_ENST00000495786.1_3'UTR|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CAGCATCCTGGGTTAGACGGA	0.537000													14	62					6.31663e-08	7.90207e-08	0.132662	1	0
PSMD3	5709	broad.mit.edu	37	17	38153787	38153787	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:38153787G>A	ENST00000264639.4	+	12	1732	c.1558G>A	c.(1558-1560)Gag>Aag	p.E520K	PSMD3_ENST00000541736.1_3'UTR	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	520					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding	p.E520Q(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					GCAGGACTTGGAGTTTGCCAA	0.607000													12	36					0	0	0.146539	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751832	140751832	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140751832G>C	ENST00000576222.1	+	1	2002	c.1871G>C	c.(1870-1872)gGt>gCt	p.G624A	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGCACGGGTGAGGTGCGC	0.687000													6	29					0	0	0.038147	0	0
OR5I1	10798	broad.mit.edu	37	11	55703852	55703852	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:55703852T>A	ENST00000301532.3	-	1	24	c.25A>T	c.(25-27)Acg>Tcg	p.T9S		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GTGACCAACGTGTAGTTTCTA	0.328000													11	55					0	0	0.069234	0	0
ADD3	120	broad.mit.edu	37	10	111890136	111890136	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:111890136G>A	ENST00000277900.8	+	13	1989	c.1624G>A	c.(1624-1626)Gat>Aat	p.D542N	ADD3_ENST00000356080.4_Missense_Mutation_p.D542N|ADD3_ENST00000360162.3_Missense_Mutation_p.D542N	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	542						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GCAATTTGAAGATGATGATCA	0.348000													4	94					0	0	0.038395	0	0
TRAPPC5	126003	broad.mit.edu	37	19	7747434	7747434	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:7747434G>T	ENST00000317378.5	+	2	482	c.295G>T	c.(295-297)Ggc>Tgc	p.G99C	TRAPPC5_ENST00000596148.1_Missense_Mutation_p.G99C|TRAPPC5_ENST00000595985.1_Missense_Mutation_p.G32C|CTD-3214H19.16_ENST00000597959.1_3'UTR|TRAPPC5_ENST00000426877.2_Missense_Mutation_p.G99C	NM_174894.2	NP_777554.1	Q8IUR0	TPPC5_HUMAN	trafficking protein particle complex 5	99					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding			NS(1)|lung(2)	3						GGCGCTCTTCGGCAAGGAGGC	0.642000													9	17					3.07112e-06	3.5716e-06	0.080935	1	0
PCDH11X	27328	broad.mit.edu	37	X	91133015	91133015	+	Silent	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:91133015C>A	ENST00000373094.1	+	2	2621	c.1776C>A	c.(1774-1776)atC>atA	p.I592I	PCDH11X_ENST00000361655.2_Silent_p.I592I|PCDH11X_ENST00000298274.8_Silent_p.I592I|PCDH11X_ENST00000504220.1_Silent_p.I592I|PCDH11X_ENST00000361724.1_Silent_p.I592I|PCDH11X_ENST00000373088.1_Silent_p.I592I|PCDH11X_ENST00000395337.2_Silent_p.I592I|PCDH11X_ENST00000373097.1_Silent_p.I592I|PCDH11X_ENST00000406881.1_Silent_p.I592I	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	592	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TAGGACTAATCACTGTAACTG	0.398000													15	64					8.10497e-08	1.00991e-07	0.055883	1	0
NRXN3	9369	broad.mit.edu	37	14	79423671	79423671	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:79423671C>T	ENST00000554719.1	+	8	1734	c.1243C>T	c.(1243-1245)Ctt>Ttt	p.L415F	NRXN3_ENST00000335750.5_Missense_Mutation_p.L415F	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	185					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AGGAAAAAGCCTTAAGTTAAC	0.493000													20	58					0	0	0.062417	0	0
KDR	3791	broad.mit.edu	37	4	55963852	55963852	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:55963852G>T	ENST00000263923.4	-	18	2886	c.2591C>A	c.(2590-2592)aCa>aAa	p.T864K		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	864	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GACTGCTACTGTCCTGCAAGT	0.403000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			13	61					0.000308642	0.000338859	0.132662	1	0
HRG	3273	broad.mit.edu	37	3	186395280	186395280	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:186395280C>A	ENST00000232003.4	+	7	1266	c.1186C>A	c.(1186-1188)Ccc>Acc	p.P396T		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	396	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		tggacaccacccccatggaca	0.552000													10	24					3.86212e-05	4.33109e-05	0.069234	1	0
PDZD7	79955	broad.mit.edu	37	10	102783311	102783311	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:102783311C>A	ENST00000370215.3	-	4	649	c.424G>T	c.(424-426)Gag>Tag	p.E142*	PDZD7_ENST00000470414.1_Nonsense_Mutation_p.E142*	NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	142	PDZ 1.					cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		GTGGTGCTCTCCAGGCTCAGC	0.652000													8	30					0.0692343	0.0719853	0.069234	1	0
MAGI3	260425	broad.mit.edu	37	1	114226575	114226575	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:114226575G>A	ENST00000307546.9	+	21	4460	c.4385G>A	c.(4384-4386)tGg>tAg	p.W1462*	MAGI3_ENST00000369615.1_3'UTR	NM_001142782.1	NP_001136254.1	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	1487					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAGGGCCCTGGAAGGTTCCA	0.413000													7	36					0	0	0.047766	0	0
CSMD2	114784	broad.mit.edu	37	1	34383799	34383799	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:34383799G>T	ENST00000373381.4	-	5	992	c.816C>A	c.(814-816)atC>atA	p.I272I		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	232	CUB 2.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTCAGCCAGGATGGTCCATG	0.587000													11	48					7.93312e-07	9.36466e-07	0.119110	1	0
AKAP6	9472	broad.mit.edu	37	14	33290934	33290934	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:33290934G>T	ENST00000280979.4	+	13	4085	c.3915G>T	c.(3913-3915)ctG>ctT	p.L1305L	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1305					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TGCCATTTCTGAAAAACAATC	0.413000													20	70					8.24728e-16	1.2158e-15	0.099896	1	0
AQR	9716	broad.mit.edu	37	15	35210473	35210473	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:35210473T>A	ENST00000156471.5	-	15	1553	c.1328A>T	c.(1327-1329)tAc>tTc	p.Y443F		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	443						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TCCAGAATAGTACTCAGTTGG	0.353000													6	15					0	0	0.021553	0	0
MROH2B	133558	broad.mit.edu	37	5	41018009	41018009	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:41018009G>C	ENST00000399564.4	-	28	3277	c.2827C>G	c.(2827-2829)Ctg>Gtg	p.L943V	MROH2B_ENST00000506092.2_Missense_Mutation_p.L498V	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ATGGTGGGCAGGGTATCACAG	0.483000													8	29					0	0	0.058154	0	0
MAPKAPK2	9261	broad.mit.edu	37	1	206906050	206906050	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:206906050C>T	ENST00000367103.3	+	10	1383	c.1190C>T	c.(1189-1191)gCt>gTt	p.A397V	MAPKAPK2_ENST00000294981.4_3'UTR	NM_004759.4|NM_032960.3	NP_004750.1|NP_116584.2	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated protein kinase 2	397					activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	19	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			GAGGCTGCGGCTCTGGCCCAC	0.527000													15	38					0	0	0.049695	0	0
UFSP2	55325	broad.mit.edu	37	4	186339797	186339797	+	Silent	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:186339797G>T	ENST00000264689.6	-	3	326	c.210C>A	c.(208-210)acC>acA	p.T70T	UFSP2_ENST00000502282.1_5'UTR	NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	70						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		CTCCAGGAATGGTGTTTATGT	0.393000													24	80					7.92952e-12	1.07322e-11	0.091800	1	0
PSG6	5675	broad.mit.edu	37	19	43421938	43421938	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:43421938G>T	ENST00000187910.2	-	1	72	c.7C>A	c.(7-9)Ccc>Acc	p.P3T	PSG6_ENST00000601833.1_Intron|PSG6_ENST00000292125.2_Missense_Mutation_p.P3T|PSG6_ENST00000402603.4_Missense_Mutation_p.P3T	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GCTGAGAGGGGTCCCATGGTC	0.602000													27	84					7.68411e-24	1.17698e-23	0.134883	1	0
IQGAP3	128239	broad.mit.edu	37	1	156503601	156503601	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:156503601C>A	ENST00000361170.2	-	31	3950	c.3940G>T	c.(3940-3942)Gat>Tat	p.D1314Y		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1314					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCCCCAAGATCCTCCAGGAGC	0.602000													6	42					0.0692343	0.0719853	0.069234	1	0
ATM	472	broad.mit.edu	37	11	108175416	108175416	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:108175416T>G	ENST00000278616.4	+	37	5896	c.5511T>G	c.(5509-5511)ttT>ttG	p.F1837L	ATM_ENST00000452508.2_Missense_Mutation_p.F1837L	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1837					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AAACTGACTTTTGTCAGACTG	0.308000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			11	40					0	0	0.093190	0	0
COL9A1	1297	broad.mit.edu	37	6	71003934	71003934	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:71003934G>T	ENST00000357250.6	-	5	790	c.632C>A	c.(631-633)cCa>cAa	p.P211Q	COL9A1_ENST00000370496.3_Missense_Mutation_p.P211Q	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	211	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding	p.P211Q(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AATGTCAATTGGGCCTCTTGG	0.423000													58	74					1.16596e-39	1.86791e-39	0.139131	1	0
LIG3	3980	broad.mit.edu	37	17	33326409	33326409	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:33326409C>T	ENST00000378526.4	+	15	2330	c.2197C>T	c.(2197-2199)Cat>Tat	p.H733Y	LIG3_ENST00000262327.5_Missense_Mutation_p.H733Y	NM_013975.3	NP_039269.2	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent	733					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			endometrium(4)|large_intestine(8)|lung(9)|ovary(3)|pancreas(2)|prostate(1)|skin(3)|stomach(1)	31		Ovarian(249;0.17)			Bleomycin(DB00290)	TGCAGGAGGCCATGATGATGC	0.587000								Other BER factors					15	31					0	0	0.146539	0	0
WNK3	65267	broad.mit.edu	37	X	54334456	54334456	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:54334456C>T	ENST00000354646.2	-	5	1426	c.988G>A	c.(988-990)Gat>Aat	p.D330N	WNK3_ENST00000375159.2_Missense_Mutation_p.D330N|WNK3_ENST00000375169.3_Missense_Mutation_p.D330N	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	330	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						GCATAAACATCTACGGATTCA	0.393000													19	83					0	0	0.049695	0	0
ADD3	120	broad.mit.edu	37	10	111890202	111890202	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:111890202G>A	ENST00000277900.8	+	13	2055	c.1690G>A	c.(1690-1692)Gag>Aag	p.E564K	ADD3_ENST00000356080.4_Missense_Mutation_p.E564K|ADD3_ENST00000360162.3_Missense_Mutation_p.E564K	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	564						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		AGAACTTGAAGAGTATAAGAG	0.378000													20	121					0	0	0.069288	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579470	140579470	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:140579470C>A	ENST00000354757.3	+	1	123	c.123C>A	c.(121-123)agC>agA	p.S41R	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		41	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGCAGAGCGGGAGTTTTG	0.522000													12	36					2.62699e-14	3.76655e-14	0.132662	1	0
TECRL	253017	broad.mit.edu	37	4	65274942	65274942	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:65274942G>T	ENST00000381210.3	-	1	238	c.128C>A	c.(127-129)gCg>gAg	p.A43E	TECRL_ENST00000507440.1_Missense_Mutation_p.A43E	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	43					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TAGAGGGCCCGCTGAGAGTAC	0.393000													17	48					1.00905e-13	1.41447e-13	0.049695	1	0
BPTF	2186	broad.mit.edu	37	17	65907022	65907022	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:65907022G>A	ENST00000321892.4	+	13	3461	c.3400G>A	c.(3400-3402)Gat>Aat	p.D1134N	BPTF_ENST00000306378.6_Missense_Mutation_p.D1008N|BPTF_ENST00000335221.5_Missense_Mutation_p.D1134N|BPTF_ENST00000424123.3_Missense_Mutation_p.D995N			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1134					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTCTGACAGTGATAAACCCTG	0.333000													7	35					0	0	0.029380	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47337315	47337316	+	RNA	INS	-	-	T	rs149213285	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:47337315_47337316insT	ENST00000505841.1	-	0	879					NR_002788.2																						taatttttaaatttttgtagag	0.490													6	4	---	---	---	---					
RP4-683M8.2	0	broad.mit.edu	37	1	48524241	48524242	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:48524241_48524242insG	ENST00000439795.1	+	0	185																											GGTTGTGGGGAGGGGGGAGACC	0.446													3	4	---	---	---	---					
LOC101926964	101926964	broad.mit.edu	37	1	61202009	61202012	+	RNA	DEL	TGTG	TGTG	-	rs71756661		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:61202009_61202012delTGTG	ENST00000423403.1	-	0	249																											caaagatgcatgtgtgtgtgtgtg	0.382													3	2	---	---	---	---					
RP4-771M4.3	0	broad.mit.edu	37	1	63362017	63362018	+	RNA	INS	-	-	ACAC	rs67161884	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:63362017_63362018insACAC	ENST00000450811.1	+	0	101																											CATTTTCTGTTacacacacaca	0.351													5	2	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68361515	68361516	+	RNA	INS	-	-	A	rs145881425	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:68361515_68361516insA	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000413628.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			agtgcccatttaaaAAAAAATG	0.307													4	2	---	---	---	---					
RP11-424D14.1	0	broad.mit.edu	37	1	69573549	69573550	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:69573549_69573550insA	ENST00000425517.1	+	0	317																											gactctgtctcaaaaaaaaaaa	0.455													2	4	---	---	---	---					
RP11-424D14.1	0	broad.mit.edu	37	1	69589276	69589277	+	RNA	INS	-	-	CT	rs10634406	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:69589276_69589277insCT	ENST00000425517.1	+	0	317																											tcttttttctcctctctctctc	0.431													3	4	---	---	---	---					
LOC101927244	101927244	broad.mit.edu	37	1	71191618	71191619	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:71191618_71191619insT	ENST00000419450.1	+	0	637																											gtgacccctgctttttttttcc	0.351													2	4	---	---	---	---					
RP4-788P17.1	0	broad.mit.edu	37	1	74103049	74103049	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:74103049delC	ENST00000424953.1	+	0	26																											cattcaacaacccatgtaatc	0.368													2	4	---	---	---	---					
LOC101927587	101927587	broad.mit.edu	37	1	84282869	84282870	+	RNA	DEL	CA	CA	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:84282869_84282870delCA	ENST00000417975.1	-	0	178																											cattcacacccacacacacaca	0.386													3	4	---	---	---	---					
RP11-202K23.1	0	broad.mit.edu	37	1	102853536	102853536	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:102853536delC	ENST00000447916.1	-	0	232																											CTAAAATCTGCCTGGAGATGA	0.323													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142631481	142631481	+	RNA	DEL	C	C	-	rs142199870		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:142631481delC	ENST00000369381.2	-	0	5218				RP11-417J8.3_ENST00000426408.1_lincRNA																							accctttcttccagttgatcg	0.403													5	2	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142647217	142647217	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:142647217delA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							actctgtctcaaaaaaaaaaa	0.443													2	4	---	---	---	---					
RP11-423O2.5	0	broad.mit.edu	37	1	142804885	142804885	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:142804885delA	ENST00000423385.1	-	0	356																											TTTTTTTTTTAAATCAAGGAC	0.328													10	7	---	---	---	---					
RP11-435B5.6	0	broad.mit.edu	37	1	143504722	143504722	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:143504722delT	ENST00000429884.1	+	0	167																											gtactcttaattttttattta	0.294													4	4	---	---	---	---					
RP4-791M13.3	0	broad.mit.edu	37	1	144833624	144833624	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:144833624delA	ENST00000466343.2	-	0	415																											aggaaatcctaaaaggaataa	0.308													2	4	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152170075	152170077	+	RNA	DEL	TCC	TCC	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:152170075_152170077delTCC	ENST00000420707.1	+	0	158				FLG-AS1_ENST00000593011.1_RNA																							tttcttctcttcctcctcctcct	0.488													2	4	---	---	---	---					
RP11-306I1.2	0	broad.mit.edu	37	1	165589648	165589649	+	RNA	INS	-	-	C	rs34110096	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:165589648_165589649insC	ENST00000452618.1	+	0	315																											tatacactgggcccaaatattc	0.426													5	3	---	---	---	---					
LOC102724661	102724661	broad.mit.edu	37	1	177332523	177332524	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:177332523_177332524insT	ENST00000451341.1	+	0	284																											TTGTTTTTGTGTTTTTAAATAA	0.376													2	4	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187214190	187214191	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:187214190_187214191insT	ENST00000458683.1	+	0	105																											TATTTTTCAAGTTTTTTTTTCC	0.347													2	4	---	---	---	---					
LOC400800	400800	broad.mit.edu	37	1	199272207	199272208	+	RNA	DEL	AT	AT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:199272207_199272208delAT	ENST00000452199.1	+	0	309																											atatatctccatatatatatat	0.366													2	4	---	---	---	---					
RP11-554K11.2	0	broad.mit.edu	37	1	213702792	213702792	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:213702792delT	ENST00000417161.1	+	0	275																											AATATGTACATTTTTTTAACC	0.378													2	4	---	---	---	---					
LOC101927787	101927787	broad.mit.edu	37	1	234785247	234785253	+	RNA	DEL	GATAGAT	GATAGAT	-	rs5781794		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr1:234785247_234785253delGATAGAT	ENST00000417805.1	+	0	217																											tagatagatagatagatgatagataga	0.386													3	5	---	---	---	---					
AC079779.6	0	broad.mit.edu	37	2	319054	319067	+	RNA	DEL	GGGCATGTGTGTGC	GGGCATGTGTGTGC	-	rs115023434	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:319054_319067delGGGCATGTGTGTGC	ENST00000436808.2	+	0	11																											acgtgagtgtgggcatgtgtgtgcgggcatgtga	0.645													2	4	---	---	---	---					
LINC01115	339822	broad.mit.edu	37	2	849942	849943	+	RNA	INS	-	-	CT			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:849942_849943insCT	ENST00000414556.1	-	0	309					NR_033880.1																						ctctctctcacctctctctctc	0.470													2	4	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	3073844	3073845	+	RNA	INS	-	-	A	rs142249305	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:3073844_3073845insA	ENST00000457478.1	-	0	438																											tgtctcaccacaaaaaatgagt	0.322													6	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12302473	12302474	+	RNA	DEL	AC	AC	-	rs111715878		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:12302473_12302474delAC	ENST00000412294.1	+	0	197																											CTGCCCGATGacacacacacac	0.490													3	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	13898228	13898229	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:13898228_13898229insG	ENST00000420828.1	+	0	783_784																											gtgtattctgtgggggggatgg	0.342													2	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14518029	14518031	+	RNA	DEL	TCT	TCT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:14518029_14518031delTCT	ENST00000418420.1	-	0	116					NR_103814.1																						cctctctctctcttcttctttca	0.429													6	2	---	---	---	---					
AC008069.1	0	broad.mit.edu	37	2	16922342	16922343	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:16922342_16922343insC	ENST00000448650.1	+	0	56																											cctcccaaaggccccccctgct	0.505													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22244948	22244949	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:22244948_22244949insC	ENST00000450551.1	-	0	200																											CCACAACTCTTCCCCCTCCCTT	0.386													2	4	---	---	---	---					
AC016768.1	0	broad.mit.edu	37	2	23303068	23303068	+	RNA	DEL	A	A	-	rs36041303		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:23303068delA	ENST00000421581.1	-	0	91																											attcttagataaaatcccatt	0.308													3	4	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40245046	40245047	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:40245046_40245047insA	ENST00000418854.1	+	0	132				SLC8A1-AS1_ENST00000599740.1_RNA																							aggactcatgcaaaaaaaCcaa	0.342													2	4	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40290991	40290992	+	RNA	DEL	GA	GA	-	rs34176075	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:40290991_40290992delGA	ENST00000439606.1	+	0	249				SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000418854.1_RNA																							gtgtgtgtgtgagatgcttgtg	0.426													4	7	---	---	---	---					
AC079807.4	0	broad.mit.edu	37	2	48378837	48378837	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:48378837delC	ENST00000447571.1	-	0	240																		p.0?(2)									tcttcttgtaccccacgcttg	0.318													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52244356	52244356	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:52244356delT	ENST00000440698.1	+	0	879																											ccagagctggttttctggttc	0.398													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65916892	65916893	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:65916892_65916893insC	ENST00000377977.3	+	0	862																											GGCAGAGGGGACCCCCCCAAGC	0.535													3	4	---	---	---	---					
LINC00152	112597	broad.mit.edu	37	2	87834869	87834870	+	RNA	INS	-	-	AC			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:87834869_87834870insAC	ENST00000409054.1	+	0	278					NR_015395.1																						TCTCTCCATGAacacacacaca	0.495													3	5	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89073098	89073099	+	RNA	INS	-	-	A	rs145200928	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:89073098_89073099insA	ENST00000393525.3	+	0	401																											CTTTGGTAGATACAGTGTTTTA	0.317													3	4	---	---	---	---					
ANKRD36C	400986	broad.mit.edu	37	2	96525717	96525718	+	Frame_Shift_Ins	INS	-	-	T	rs77057279	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:96525717_96525718insT	ENST00000456556.1	-	61	3871_3872	c.3787_3788insA	c.(3787-3789)gaafs	p.E1263fs	ANKRD36C_ENST00000419039.2_Frame_Shift_Ins_p.E290fs|ANKRD36C_ENST00000420871.2_Frame_Shift_Ins_p.E514fs					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						CTTATTTTTCAGTTTTCGAATT	0.282													5	8	---	---	---	---					
AC108051.1	0	broad.mit.edu	37	2	103593055	103593056	+	RNA	DEL	AC	AC	-	rs67141422		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:103593055_103593056delAC	ENST00000431897.1	-	0	74																											acacacacatacacacacacac	0.376													2	4	---	---	---	---					
GACAT1	104326057	broad.mit.edu	37	2	108415369	108415370	+	RNA	INS	-	-	T	rs35174011	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:108415369_108415370insT	ENST00000419650.1	+	0	245																											CAGTTTCAGTCTTTTTGAGTTA	0.535													5	2	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145608179	145608179	+	RNA	DEL	T	T	-	rs75787663		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:145608179delT	ENST00000445791.1	+	0	307					NR_033870.2																						ATTTAAAGTGTTTTTTTTTTT	0.303													3	3	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165184050	165184051	+	RNA	DEL	TT	TT	-	rs59117666		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:165184050_165184051delTT	ENST00000429636.1	-	0	104																											TTGTTGTGTGtttttttttttt	0.366													2	4	---	---	---	---					
AC074363.1	0	broad.mit.edu	37	2	168182791	168182794	+	RNA	DEL	TTGT	TTGT	-	rs148399278		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:168182791_168182794delTTGT	ENST00000442316.1	+	0	164																											cttaattggattgtttgttttttc	0.338													3	6	---	---	---	---					
AC074363.1	0	broad.mit.edu	37	2	168264526	168264537	+	RNA	DEL	ACACACACACAC	ACACACACACAC	-	rs58271290		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:168264526_168264537delACACACACACAC	ENST00000442316.1	+	0	164																											gcaggcaaagacacacacacacacacacacac	0.406													2	4	---	---	---	---					
AC007319.1	0	broad.mit.edu	37	2	187958554	187958555	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:187958554_187958555insG	ENST00000412276.1	+	0	92				AC007319.1_ENST00000453517.1_RNA																							ttctctgtcctggggggagaca	0.356													2	4	---	---	---	---					
AC007879.1	0	broad.mit.edu	37	2	208041686	208041687	+	RNA	DEL	GT	GT	-	rs112498669		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:208041686_208041687delGT	ENST00000435643.1	+	0	181																											TTGAGTGAGGgtgtgtgtgtgt	0.431													3	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208329302	208329303	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:208329302_208329303insG	ENST00000418850.1	-	0	256				AC007879.5_ENST00000412387.1_RNA																							ctcctgttgatgggggcaattc	0.505													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217824611	217824612	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:217824611_217824612insG	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							attattatTGAGGAATTTTTTT	0.441													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221485284	221485284	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:221485284delA	ENST00000414512.1	+	0	368																											aaaaattgccaggcgtggtga	0.483													2	4	---	---	---	---					
LINC01237	101927289	broad.mit.edu	37	2	242931922	242931923	+	RNA	INS	-	-	ATGCATCT	rs147538776	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr2:242931922_242931923insATGCATCT	ENST00000415434.1	+	0	310																											attatccatccatccatccacc	0.500													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64786773	64786773	+	RNA	DEL	C	C	-	rs71102821		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:64786773delC	ENST00000460833.1	+	0	2063				ADAMTS9-AS2_ENST00000474768.1_RNA|ADAMTS9-AS2_ENST00000481312.1_RNA																							aaaaaaaaaacaaaaaaaaaa	0.418													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64954945	64954946	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:64954945_64954946insC	ENST00000474768.1	+	0	663				ADAMTS9-AS2_ENST00000481312.1_RNA																							TCGCTTTTTATCCCCCCCGCCG	0.475													2	4	---	---	---	---					
RP11-85I21.1	0	broad.mit.edu	37	3	67348251	67348252	+	RNA	INS	-	-	ACACACACAC	rs60106362	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:67348251_67348252insACACACACAC	ENST00000484222.1	+	0	104																											tatacatatgtacacacacaca	0.386													2	4	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67976817	67976817	+	RNA	DEL	G	G	-	rs111682452		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:67976817delG	ENST00000482677.1	+	0	1653																											gattgcttgagcctaggagtt	0.443													4	2	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82092644	82092645	+	RNA	DEL	AG	AG	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:82092644_82092645delAG	ENST00000470263.1	+	0	244																											GAagagagatagagagagagag	0.426													3	4	---	---	---	---					
RP11-572M11.4	0	broad.mit.edu	37	3	112805456	112805457	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:112805456_112805457insG	ENST00000460707.1	+	0	390				RP11-572M11.4_ENST00000467342.1_RNA|RP11-572M11.4_ENST00000496389.1_RNA|RP11-572M11.4_ENST00000470313.1_RNA																							GGGAAAGTGAAGGGGGGGTCCT	0.564													2	4	---	---	---	---					
RP11-384F7.1	0	broad.mit.edu	37	3	118173223	118173224	+	RNA	INS	-	-	AA	rs142935260	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:118173223_118173224insAA	ENST00000482142.1	-	0	232																											cacatgcacctaaaggtggtgg	0.535													4	2	---	---	---	---					
LOC101927123	101927123	broad.mit.edu	37	3	127081410	127081410	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:127081410delA	ENST00000488425.1	-	0	225																											GGGAGAGCCCATGTCCCATGA	0.597													2	4	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146817541	146817541	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:146817541delG	ENST00000473299.1	-	0	229																											attctcacaaggggggtacaa	0.483													5	6	---	---	---	---					
LINC01324	104355289	broad.mit.edu	37	3	164501722	164501723	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr3:164501722_164501723insC	ENST00000497379.2	-	0	67																											ttccatggtctccccctctccc	0.614													2	4	---	---	---	---					
STX18-AS1	100507266	broad.mit.edu	37	4	4557092	4557093	+	RNA	INS	-	-	A	rs11413961	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:4557092_4557093insA	ENST00000502693.1	+	0	357				STX18-AS1_ENST00000512438.1_RNA|STX18-AS1_ENST00000507244.1_RNA																							TAGTTAGTCATAAAAAAACCCA	0.446													5	1	---	---	---	---					
RP11-472K22.1	0	broad.mit.edu	37	4	29183216	29183216	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:29183216delT	ENST00000503299.1	+	0	468																											tagaataatcttaaataatcg	0.388													2	4	---	---	---	---					
LOC344967	344967	broad.mit.edu	37	4	40058324	40058325	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:40058324_40058325insG	ENST00000381811.2	-	0	239					NR_027277.1																						CCGGCGGGCTTGGGGGGGGGCG	0.797													2	4	---	---	---	---					
RP11-463H12.2	0	broad.mit.edu	37	4	55813297	55813298	+	RNA	INS	-	-	AC	rs150613832	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:55813297_55813298insAC	ENST00000509711.1	+	0	58																											ttagggtatgtacacacacaca	0.446													3	6	---	---	---	---					
LINC00989	100506035	broad.mit.edu	37	4	80443977	80443978	+	RNA	INS	-	-	T	rs79586971		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:80443977_80443978insT	ENST00000508174.1	+	0	760																											TGATGATTATGTTTTTTTTTTT	0.381													2	4	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105467479	105467479	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:105467479delA	ENST00000500179.1	+	0	96																											TTATGAGCCCAAAAGACAGAA	0.373													2	4	---	---	---	---					
RP11-556I14.2	0	broad.mit.edu	37	4	105737873	105737874	+	RNA	DEL	AC	AC	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:105737873_105737874delAC	ENST00000515127.1	-	0	366																											ATACTTTGATacacacacacac	0.312													2	4	---	---	---	---					
LOC100996694	100996694	broad.mit.edu	37	4	120869573	120869574	+	RNA	INS	-	-	AA	rs10718219		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:120869573_120869574insAA	ENST00000505122.2	+	0	136																											aactctgtctcaaaaaaaaaaa	0.376													2	4	---	---	---	---					
RP11-679C8.2	0	broad.mit.edu	37	4	121199614	121199615	+	RNA	INS	-	-	GA	rs143322765	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:121199614_121199615insGA	ENST00000508362.1	+	0	138				RP11-679C8.2_ENST00000504106.1_RNA																							tgtgtgtgtgtgACTTTGAGTT	0.332													7	1	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128306195	128306195	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:128306195delG	ENST00000504050.1	-	0	368																											aaaccacaatgagatatggtc	0.323													2	4	---	---	---	---					
RP11-775H9.2	0	broad.mit.edu	37	4	137122739	137122739	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:137122739delC	ENST00000513332.1	-	0	279																											tcttccatgacccacggcttc	0.527													2	4	---	---	---	---					
SLC7A11-AS1	641364	broad.mit.edu	37	4	139079206	139079207	+	RNA	INS	-	-	A	rs33961527		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:139079206_139079207insA	ENST00000510767.1	+	0	1725				SLC7A11-AS1_ENST00000512786.1_RNA	NR_038380.1																						gagtttggtggaaaaaaaaaca	0.361													3	5	---	---	---	---					
RP11-98O2.1	0	broad.mit.edu	37	4	139718822	139718823	+	RNA	INS	-	-	TGTG	rs72516471		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:139718822_139718823insTGTG	ENST00000502606.1	+	0	144																											AAGAATAtgtatatgtgtgagt	0.416													3	4	---	---	---	---					
RP11-526A4.1	0	broad.mit.edu	37	4	150396785	150396786	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:150396785_150396786insG	ENST00000511993.1	-	0	1878																											tgtagcactgaggggggaagaa	0.416													2	4	---	---	---	---					
LOC101928877	101928877	broad.mit.edu	37	4	185978121	185978121	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:185978121delT	ENST00000509017.1	+	0	404																											tattgatgccttagaatattc	0.368													2	4	---	---	---	---					
RP11-706F1.1	0	broad.mit.edu	37	4	190115586	190115586	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr4:190115586delA	ENST00000514966.1	+	0	177																											ATATCCTAGCAAATAGGAGCA	0.373													2	4	---	---	---	---					
LINC01511	100506791	broad.mit.edu	37	5	1376960	1376961	+	RNA	DEL	AC	AC	-	rs10532046		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:1376960_1376961delAC	ENST00000504989.1	-	0	506																											ttaccaaaaaacaaaaacagtg	0.302													2	4	---	---	---	---					
RP11-445O3.2	0	broad.mit.edu	37	5	4766779	4766784	+	RNA	DEL	TGTGTG	TGTGTG	-	rs71602183		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:4766779_4766784delTGTGTG	ENST00000507435.1	-	0	429																											atcgccattctgtgtgtgtgtgtgtg	0.510													2	4	---	---	---	---					
LINC01020	340094	broad.mit.edu	37	5	5043429	5043432	+	RNA	DEL	AAAG	AAAG	-	rs66711034		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:5043429_5043432delAAAG	ENST00000508201.1	+	0	308																											cttaccacaaaaagaaagaaagaa	0.373													5	7	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9775742	9775743	+	RNA	DEL	CT	CT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:9775742_9775743delCT	ENST00000511616.1	-	0	521					NR_027112.2																						ggctcaagggctctctctctct	0.525													2	4	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9834865	9834866	+	RNA	INS	-	-	A	rs144394874		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:9834865_9834866insA	ENST00000511616.1	-	0	521					NR_027112.2																						ATTACTGCATTAAAAAAAAAAA	0.411													3	5	---	---	---	---					
CTD-2023M8.1	0	broad.mit.edu	37	5	18737199	18737200	+	RNA	DEL	CA	CA	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:18737199_18737200delCA	ENST00000512978.1	-	0	176																											CTCTCCCTCTCACACACACACA	0.391													2	4	---	---	---	---					
RP11-124N3.3	0	broad.mit.edu	37	5	18999971	18999972	+	RNA	DEL	TG	TG	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:18999971_18999972delTG	ENST00000504827.1	-	0	289																											GTTAACAAACTGTGCAAAATCA	0.351													4	3	---	---	---	---					
RP11-774D14.1	0	broad.mit.edu	37	5	20923264	20923265	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:20923264_20923265insA	ENST00000502427.1	+	0	541																											cactccactagaaaaaaaaaat	0.416													3	4	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21536533	21536538	+	RNA	DEL	ATAAGC	ATAAGC	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:21536533_21536538delATAAGC	ENST00000607545.1	+	0	314					NR_027026.1																						gtttataacaataagctggctgcagt	0.422													3	5	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21539615	21539616	+	RNA	INS	-	-	TA	rs71310756	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:21539615_21539616insTA	ENST00000607545.1	+	0	314					NR_027026.1																						aacagaaagacatactgcctga	0.376													7	3	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21569539	21569539	+	RNA	DEL	T	T	-	rs35875149		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:21569539delT	ENST00000607545.1	+	0	314					NR_027026.1																						ttgggtctcatttttttttcc	0.244													4	3	---	---	---	---					
RP11-152K4.2	0	broad.mit.edu	37	5	31176545	31176546	+	RNA	INS	-	-	T	rs149830888	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:31176545_31176546insT	ENST00000523584.1	-	0	125																											GGGAGACACTGTTTTTGGTTTT	0.386													4	3	---	---	---	---					
LOC101928539	101928539	broad.mit.edu	37	5	57192199	57192200	+	RNA	INS	-	-	ATA	rs147011943	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:57192199_57192200insATA	ENST00000510444.1	-	0	2789_2790																											AAATGCTTGTGATAAATTAAAG	0.351													4	2	---	---	---	---					
MSH3	4437	broad.mit.edu	37	5	79950724	79950725	+	In_Frame_Ins	INS	-	-	CCGCAGCGC	rs70991168		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:79950724_79950725insCCGCAGCGC	ENST00000265081.6	+	1	258_259	c.178_179insCCGCAGCGC	c.(178-180)cgc>CCGCAGCGCcgc	p.59_60insPQR	DHFR_ENST00000439211.2_5'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	59	Poly-Ala.		Missing.		maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		ggccgcagcggccgcagcgCCC	0.708								Mismatch excision repair (MMR)					4	2	---	---	---	---					
AC008834.1	0	broad.mit.edu	37	5	97466700	97466701	+	RNA	INS	-	-	T	rs77191694	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:97466700_97466701insT	ENST00000505908.1	-	0	454																											AGTGGTGCCACTTTCCAGGATG	0.431													7	2	---	---	---	---					
LOC285638	285638	broad.mit.edu	37	5	108574815	108574816	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:108574815_108574816insG	ENST00000512693.1	-	0	4472																											ATTGTTTATAAGGGGGGGTCCC	0.441													3	4	---	---	---	---					
LOC101927379	101927379	broad.mit.edu	37	5	121989261	121989270	+	RNA	DEL	ATTACATTAC	ATTACATTAC	-	rs6875718		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:121989261_121989270delATTACATTAC	ENST00000511194.1	-	0	921																											TATATCATCTattacattacattacattac	0.324													2	4	---	---	---	---					
CTB-57H20.1	0	broad.mit.edu	37	5	143161544	143161545	+	RNA	INS	-	-	GT	rs141034350	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:143161544_143161545insGT	ENST00000503323.1	+	0	379																											gtgtgtttaaggtgtgtgtgtg	0.460													3	3	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151501916	151501917	+	RNA	INS	-	-	C	rs11446591	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:151501916_151501917insC	ENST00000524295.1	+	0	199																											TTAGTAATAATCCCTACCTGTT	0.347													3	3	---	---	---	---					
LOC101927740	101927740	broad.mit.edu	37	5	158539317	158539317	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:158539317delT	ENST00000499583.1	+	0	297																											ATTAACCACCTTTTTTTTTCT	0.388													3	4	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	164497373	164497374	+	RNA	INS	-	-	G	rs149771468	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:164497373_164497374insG	ENST00000519570.1	+	0	451				CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000519267.1_RNA																							tatgttgaataggagtggtaag	0.386													4	3	---	---	---	---					
LINC01411	101928176	broad.mit.edu	37	5	173933999	173934000	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:173933999_173934000insA	ENST00000510234.1	+	0	194																											acaaacaaaccaaaaaaaacaa	0.475													2	4	---	---	---	---					
CTD-2532K18.1	0	broad.mit.edu	37	5	174234837	174234840	+	RNA	DEL	TTTG	TTTG	-	rs144910617		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr5:174234837_174234840delTTTG	ENST00000502684.1	+	0	50																											GCCAGGCCACTTTGTTTGATGTGT	0.397													5	3	---	---	---	---					
RP1-223B1.1	0	broad.mit.edu	37	6	3608527	3608527	+	RNA	DEL	C	C	-	rs56188206		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:3608527delC	ENST00000443445.1	-	0	500																											CCCAGCGTGGCTTCGGCAACT	0.552													7	3	---	---	---	---					
RP1-290I10.7	0	broad.mit.edu	37	6	10453180	10453181	+	RNA	DEL	TG	TG	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:10453180_10453181delTG	ENST00000366312.2	+	0	310																											tgcgcgcacctgtgtgtgtgtg	0.559													2	4	---	---	---	---					
LOC101927189	101927189	broad.mit.edu	37	6	53799546	53799546	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:53799546delG	ENST00000431554.2	+	0	232																											ttgagtccctgggaaatagac	0.403													2	4	---	---	---	---					
RP3-399L15.2	0	broad.mit.edu	37	6	114856187	114856188	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:114856187_114856188insC	ENST00000435802.1	-	0	160																											gtgtggttttaccccctgcttc	0.525													3	6	---	---	---	---					
RP11-351A11.1	0	broad.mit.edu	37	6	119266655	119266657	+	RNA	DEL	AAA	AAA	-	rs67515130		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:119266655_119266657delAAA	ENST00000518570.1	+	0	206																											aagacaaaggaaaaaaatgaatc	0.335													2	4	---	---	---	---					
RNF217-AS1	7955	broad.mit.edu	37	6	125265140	125265140	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:125265140delA	ENST00000439075.1	-	0	526					NR_026876.1																						attttttaccaaaaaaaaggt	0.303													2	4	---	---	---	---					
RP11-69I8.3	0	broad.mit.edu	37	6	132395574	132395575	+	RNA	INS	-	-	T	rs35129618		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:132395574_132395575insT	ENST00000435287.1	+	0	309																											gtccccaTGCAttttttttttt	0.426													2	4	---	---	---	---					
RP11-307P5.1	0	broad.mit.edu	37	6	148261338	148261339	+	RNA	INS	-	-	T	rs71748775		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:148261338_148261339insT	ENST00000427015.1	+	0	117																											GGCAGAATTCATTTTTTTTTTT	0.411													2	4	---	---	---	---					
RP3-495K2.3	0	broad.mit.edu	37	6	169362942	169362964	+	RNA	DEL	GGTCCTCGGGCAGGGAGGAGGCA	GGTCCTCGGGCAGGGAGGAGGCA	-	rs149014272		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:169362942_169362964delGGTCCTCGGGCAGGGAGGAGGCA	ENST00000444586.1	-	0	654_676																											TCTGAAGCTTGGTCCTCGGGCAGGGAGGAGGCAGGTCCTCGGG	0.570													2	4	---	---	---	---					
RP1-137D17.1	0	broad.mit.edu	37	6	169775969	169775970	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr6:169775969_169775970insT	ENST00000440168.1	-	0	185																											AAGGGATTGTCTTTTTTGTAAA	0.347													2	4	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11324422	11324423	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:11324422_11324423insT	ENST00000421121.1	+	0	113				AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000441110.1_RNA|AC004538.3_ENST00000445839.1_RNA|AC004538.3_ENST00000599875.1_RNA																							gatgtgtagtgttttttctgag	0.386													3	5	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11330761	11330762	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:11330761_11330762insC	ENST00000421121.1	+	0	113				AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000441110.1_RNA|AC004538.3_ENST00000445839.1_RNA|AC004538.3_ENST00000599875.1_RNA																							TTATTTCCCTGCCCCCAGCCTG	0.401													2	4	---	---	---	---					
AC006000.5	0	broad.mit.edu	37	7	13383520	13383520	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:13383520delC	ENST00000456809.1	-	0	365																											tttgctttatcccaaaggtgt	0.294													2	4	---	---	---	---					
LOC101927668	101927668	broad.mit.edu	37	7	20006826	20006827	+	RNA	INS	-	-	A	rs138379463		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:20006826_20006827insA	ENST00000449573.1	-	0	462																											agaacaacaacaacagaaataa	0.351													3	5	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34493882	34493882	+	RNA	DEL	T	T	-	rs67530038		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:34493882delT	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						CAATATGTAATTTTTTTATAT	0.249													6	3	---	---	---	---					
AC092657.2	0	broad.mit.edu	37	7	46363395	46363395	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:46363395delG	ENST00000436266.1	+	0	49																											tcctacatgtggaagccacag	0.532													2	4	---	---	---	---					
AC004901.1	0	broad.mit.edu	37	7	46990103	46990104	+	RNA	INS	-	-	TG			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:46990103_46990104insTG	ENST00000433337.1	-	0	237																											GTCTAGGTGCATGTGTGTGTGC	0.426													2	4	---	---	---	---					
RP4-724E13.2	0	broad.mit.edu	37	7	50942268	50942269	+	RNA	INS	-	-	TGGA	rs71265024	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:50942268_50942269insTGGA	ENST00000420449.1	+	0	24																											gaattgcaagctgaagaactaa	0.366													2	4	---	---	---	---					
RP5-945F2.3	0	broad.mit.edu	37	7	67734738	67734739	+	RNA	DEL	GT	GT	-	rs72303609		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:67734738_67734739delGT	ENST00000446187.1	-	0	179																											tgtgtgtgtggtgtgtgtgtgt	0.436													3	4	---	---	---	---					
AC003988.1	0	broad.mit.edu	37	7	79893792	79893792	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:79893792delA	ENST00000447198.2	-	0	202																											catgcccgtgaatgacagcaa	0.368													3	3	---	---	---	---					
LOC100128317	100128317	broad.mit.edu	37	7	81235540	81235540	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:81235540delA	ENST00000413944.2	-	0	314																											CTAGGTCAGGAAATTGAAATT	0.289													2	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89733941	89733950	+	RNA	DEL	CACACACCCC	CACACACCCC	-	rs112608068	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:89733941_89733950delCACACACCCC	ENST00000478318.2	-	0	424																											cacacacacacacacacccccacacacaca	0.333													5	4	---	---	---	---					
POT1-AS1	401398	broad.mit.edu	37	7	124602446	124602447	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:124602446_124602447insT	ENST00000453342.1	+	0	202																											gaaagtatatgtgtcaggtgtg	0.426													3	4	---	---	---	---					
AC024084.1	0	broad.mit.edu	37	7	135730917	135730920	+	RNA	DEL	TGTG	TGTG	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:135730917_135730920delTGTG	ENST00000440744.2	+	0	134																											AGGGAGAAACTGTGTGTGAGTTCC	0.466													6	1	---	---	---	---					
EPHA1-AS1	285965	broad.mit.edu	37	7	143205895	143205896	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:143205895_143205896insG	ENST00000429289.1	+	0	263					NR_033897.1																						ataatgtgagagggggtggaga	0.406													2	4	---	---	---	---					
C7orf13	129790	broad.mit.edu	37	7	156321160	156321161	+	RNA	INS	-	-	T	rs34848584	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:156321160_156321161insT	ENST00000447933.1	-	0	300																											TGAAGCTGTGGTTTTTTTCCTT	0.505													5	2	---	---	---	---					
LOC101927914	101927914	broad.mit.edu	37	7	157280615	157280615	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr7:157280615delA	ENST00000444158.1	+	0	2547																											ggcacacgggagagccgggga	0.761													5	6	---	---	---	---					
ERICH1-AS1	619343	broad.mit.edu	37	8	1071685	1071746	+	RNA	DEL	TCATCTTTCCTGAACCCATGACCACCCATCCTTGTCCCTTTAGAACCCACAACCACCCGTCT	TCATCTTTCCTGAACCCATGACCACCCATCCTTGTCCCTTTAGAACCCACAACCACCCGTCT	-	rs138695363	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:1071685_1071746delTCATCTTTCCTGAACCCATGACCACCCATCCTTGTCCCTTTAGAACCCACAACCACCCGTCT	ENST00000522092.1	+	0	332					NR_073397.1|NR_073466.1																						CCACCCAACCTCATCTTTCCTGAACCCATGACCACCCATCCTTGTCCCTTTAGAACCCACAACCACCCGTCTTCATCTTTCC	0.504													3	3	---	---	---	---					
AC100802.3	0	broad.mit.edu	37	8	19945773	19945774	+	RNA	INS	-	-	A	rs139430114		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:19945773_19945774insA	ENST00000519197.1	+	0	218																											gcctccatctcaaaaaaaaaaa	0.436													6	5	---	---	---	---					
RP11-563N12.2	0	broad.mit.edu	37	8	20227227	20227227	+	RNA	DEL	A	A	-	rs76553491		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:20227227delA	ENST00000521139.1	+	0	422																											actccatctgaaaaaaaaaaa	0.373													3	5	---	---	---	---					
RP11-213G6.2	0	broad.mit.edu	37	8	23586376	23586377	+	RNA	INS	-	-	A	rs35466576		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:23586376_23586377insA	ENST00000520375.1	-	0	162				RP11-175E9.1_ENST00000523874.1_RNA																							gagacaaggtcaaaaaaaaaaa	0.450													3	3	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24410354	24410354	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:24410354delA	ENST00000519689.1	-	0	184																											catattgttgaaatcacaaat	0.403													2	4	---	---	---	---					
LOC101929470	101929470	broad.mit.edu	37	8	29677949	29677950	+	RNA	INS	-	-	AC			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:29677949_29677950insAC	ENST00000507496.1	-	0	578																											caccacacacaacacacacacc	0.465													4	9	---	---	---	---					
LOC101929470	101929470	broad.mit.edu	37	8	29681140	29681141	+	RNA	INS	-	-	TT	rs67766739		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:29681140_29681141insTT	ENST00000507496.1	-	0	93																											AAACCCTTGTGTTTTTTTTTTT	0.411													2	4	---	---	---	---					
RP11-350F16.1	0	broad.mit.edu	37	8	47836182	47836183	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:47836182_47836183insG	ENST00000524012.1	+	0	408																											CAGGCCAGGCTGGGGGGCCATG	0.554													2	4	---	---	---	---					
RP11-162D9.3	0	broad.mit.edu	37	8	54135667	54135667	+	RNA	DEL	C	C	-	rs11300011		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:54135667delC	ENST00000524425.1	+	0	670																											atggtctcttcccctaaataa	0.393													3	3	---	---	---	---					
CTD-3046C4.1	0	broad.mit.edu	37	8	64315439	64315439	+	RNA	DEL	A	A	-	rs148500473		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:64315439delA	ENST00000521221.1	-	0	694																											ggagaaacttaaaaaaaaatg	0.398													3	6	---	---	---	---					
LOC101927040	101927040	broad.mit.edu	37	8	80758445	80758450	+	RNA	DEL	ACACAC	ACACAC	-	rs144940558		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:80758445_80758450delACACAC	ENST00000502766.2	-	0	302																											acacacataaacacacacacacacac	0.345													3	6	---	---	---	---					
CNBD1	168975	broad.mit.edu	37	8	88601749	88601749	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:88601749delA	ENST00000517711.1	-	0	232				AF121898.3_ENST00000518494.1_RNA|AF121898.3_ENST00000440763.2_RNA																							TTTGAAATATAAGCCTACCCA	0.363													2	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96482747	96482748	+	RNA	INS	-	-	TT	rs77776040	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:96482747_96482748insTT	ENST00000521905.1	+	0	281																											CTGCCTGACTCGTCTTAACCAT	0.386													4	1	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117032092	117032093	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:117032092_117032093insA	ENST00000505156.2	-	0	1558					NR_046215.1																						cactgaagcccaaaaaagggaa	0.366													2	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117049282	117049283	+	RNA	INS	-	-	T	rs139212337		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:117049282_117049283insT	ENST00000505156.2	-	0	1558					NR_046215.1																						CTCTCTCTCTCTTTTTTTTTTT	0.361													4	2	---	---	---	---					
RP11-369K17.1	0	broad.mit.edu	37	8	121976889	121976890	+	RNA	INS	-	-	ATTT	rs59567579	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:121976889_121976890insATTT	ENST00000517739.1	+	0	95																											taaatgagaggattaggggaat	0.446													5	3	---	---	---	---					
RP11-3G20.2	0	broad.mit.edu	37	8	122708871	122708872	+	RNA	INS	-	-	G	rs148519158	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:122708871_122708872insG	ENST00000458107.3	+	0	251																											CCTAAGCATCTGATGGATAAAG	0.381													8	1	---	---	---	---					
LINC01151	104266958	broad.mit.edu	37	8	123699404	123699404	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:123699404delT	ENST00000521608.1	-	0	335																											taaacgctcctcccccagggg	0.517													2	4	---	---	---	---					
RP11-89K10.1	0	broad.mit.edu	37	8	127608581	127608582	+	RNA	INS	-	-	AGAG	rs10657537	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:127608581_127608582insAGAG	ENST00000519880.1	+	0	156				RP11-89K10.1_ENST00000517915.1_RNA|RP11-89K10.1_ENST00000520512.1_RNA|RP11-89K10.1_ENST00000517773.1_RNA																							agagcaatgatagagagagaga	0.540													2	4	---	---	---	---					
RP11-89K10.1	0	broad.mit.edu	37	8	127720444	127720444	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:127720444delA	ENST00000519880.1	+	0	214																											agaaggaatcaaagagtctat	0.274													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130403730	130403731	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:130403730_130403731insG	ENST00000446592.3	-	0	360																											cccaactacttggggggctgag	0.515													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130656997	130656997	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:130656997delG	ENST00000446592.3	-	0	312																											GGCCAAACCAGGAGACAGCAT	0.398													5	6	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130681684	130681687	+	RNA	DEL	GCCT	GCCT	-	rs139967049		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr8:130681684_130681687delGCCT	ENST00000446592.3	-	0	312																											agggctggaggcctaggaggaaaa	0.525													4	5	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2586373	2586376	+	RNA	DEL	AAAC	AAAC	-	rs142174778		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:2586373_2586376delAAAC	ENST00000416826.2	-	0	185				RP11-125B21.2_ENST00000453601.1_RNA																							aatgaaattgaaacaaacaaacaa	0.294													4	3	---	---	---	---					
MIR31HG	554202	broad.mit.edu	37	9	21506652	21506653	+	RNA	INS	-	-	T	rs11389375	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:21506652_21506653insT	ENST00000304425.3	-	0	181					NR_027054.1																						TGCTTCCTTTGTTTTTTTTACC	0.342													5	6	---	---	---	---					
TMEM2	23670	broad.mit.edu	37	9	74312964	74312964	+	Frame_Shift_Del	DEL	C	C	-	rs142314012	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr9:74312964delC	ENST00000377044.4	-	20	4073	c.3534delG	c.(3532-3534)ccfs	p.P1178fs	TMEM2_ENST00000377066.5_Frame_Shift_Del_p.P1115fs|TMEM2_ENST00000396272.3_Frame_Shift_Del_p.P171fs	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	1178						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGACCACTGACGGCTTTCTGT	0.522													25	70	---	---	---	---					
LINC00701	399708	broad.mit.edu	37	10	2352886	2352886	+	RNA	DEL	A	A	-	rs142427123		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:2352886delA	ENST00000418295.1	-	0	46					NR_038884.1																						attttagacgaaaaaaaaaaa	0.368													2	4	---	---	---	---					
RP11-543F8.2	0	broad.mit.edu	37	10	8467401	8467401	+	RNA	DEL	T	T	-	rs10716344		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:8467401delT	ENST00000413286.1	+	0	141																											GGGTTTAAGATTTTTTTTTTT	0.323													2	4	---	---	---	---					
SYNPO2L	79933	broad.mit.edu	37	10	75417281	75417282	+	RNA	INS	-	-	A	rs112597540		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:75417281_75417282insA	ENST00000606726.1	+	0	268				RP11-464F9.21_ENST00000607450.1_RNA																							accctgtctccaaaaaaaaaaa	0.485													2	4	---	---	---	---					
LINC01520	101929684	broad.mit.edu	37	10	87216557	87216558	+	RNA	DEL	TG	TG	-	rs141769034		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:87216557_87216558delTG	ENST00000441457.1	+	0	1106																											acatatataatgtgtgtgtgtg	0.386													3	4	---	---	---	---					
RP11-236B18.2	0	broad.mit.edu	37	10	92761561	92761564	+	RNA	DEL	ACAC	ACAC	-	rs3061206		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:92761561_92761564delACAC	ENST00000412362.1	+	0	134																											GTAAATATGTacacacacacacac	0.373													2	4	---	---	---	---					
RP11-298J20.4	0	broad.mit.edu	37	10	126625753	126625755	+	RNA	DEL	TTT	TTT	-	rs149591784		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr10:126625753_126625755delTTT	ENST00000508096.1	+	0	130																											TTTGTGTGTAttttttttttttt	0.414													2	4	---	---	---	---					
BDNF-AS	497258	broad.mit.edu	37	11	27538255	27538255	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:27538255delT	ENST00000499008.3	+	0	47				BDNF-AS_ENST00000502161.2_RNA|BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000532965.1_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000501176.2_RNA	NR_002832.2																						ggatcccagcttttttcattt	0.398													2	4	---	---	---	---					
RP4-594L9.2	0	broad.mit.edu	37	11	34558108	34558108	+	RNA	DEL	T	T	-	rs148266584		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:34558108delT	ENST00000527984.1	-	0	236																											tttctttttcttttttttttt	0.443													2	4	---	---	---	---					
RP11-613D13.4	0	broad.mit.edu	37	11	43979388	43979389	+	RNA	INS	-	-	C	rs71449865		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:43979388_43979389insC	ENST00000526408.1	+	0	153																											atgtgtgaccgcccccccaaca	0.495													3	3	---	---	---	---					
OR4S1	256148	broad.mit.edu	37	11	48328524	48328525	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:48328524_48328525insC	ENST00000319988.1	+	1	750_751	c.750_751insC	c.(748-753)atccccfs	p.IP250fs		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						TGGTTCTCATGCCCCCCATGTT	0.480													8	240	---	---	---	---					
RP11-360K13.1	0	broad.mit.edu	37	11	96525379	96525379	+	RNA	DEL	T	T	-	rs33959701		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:96525379delT	ENST00000527528.1	+	0	158																											TTCTTCTGAGTTTTTTTTTTT	0.303													3	3	---	---	---	---					
LOC102723895	102723895	broad.mit.edu	37	11	104384055	104384055	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:104384055delT	ENST00000536529.1	-	0	422																											tttaccgatgtaacaaacctg	0.368													2	4	---	---	---	---					
RP11-820L6.1	0	broad.mit.edu	37	11	122116627	122116628	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr11:122116627_122116628insG	ENST00000527474.1	-	0	898																											acaagtcctaaggggggaatga	0.500													2	4	---	---	---	---					
RP11-1038A11.3	0	broad.mit.edu	37	12	5477364	5477364	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:5477364delA	ENST00000537192.1	+	0	351																											ATTTGAGAAGAAAAAAAAAAT	0.418													4	7	---	---	---	---					
C1S	716	broad.mit.edu	37	12	7171652	7171653	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:7171652_7171653insC	ENST00000406697.1	+	8	1101_1102	c.473_474insC	c.(472-474)tccfs	p.S158fs	C1S_ENST00000360817.5_Frame_Shift_Ins_p.S158fs|C1S_ENST00000328916.3_Frame_Shift_Ins_p.S158fs|C1S_ENST00000402681.3_5'UTR			P09871	C1S_HUMAN	complement component 1, s subcomponent	158	EGF-like; calcium-binding.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TTCTGCTCCTGCCCCCCGGAAT	0.455													7	160	---	---	---	---					
RP11-705C15.3	0	broad.mit.edu	37	12	9811484	9811485	+	RNA	INS	-	-	A	rs146817472		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:9811484_9811485insA	ENST00000537616.1	+	0	63																											ctgtgtctcagaaaaaaaaaaa	0.460													3	4	---	---	---	---					
RP11-174G6.1	0	broad.mit.edu	37	12	14869921	14869921	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:14869921delC	ENST00000501178.2	+	0	247																											CCAAGTTCCAcccactaaagg	0.473													2	4	---	---	---	---					
RP11-847H18.3	0	broad.mit.edu	37	12	34208174	34208174	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:34208174delG	ENST00000537655.1	+	0	211																											TTAAACTAAAGCAAAAGTGAA	0.323													2	4	---	---	---	---					
RP11-370I10.6	0	broad.mit.edu	37	12	48806563	48806563	+	RNA	DEL	T	T	-	rs66490262		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:48806563delT	ENST00000548257.1	+	0	237																											GGttttactcttttttttttt	0.423													2	4	---	---	---	---					
LOC100507065	100507065	broad.mit.edu	37	12	66033519	66033520	+	RNA	INS	-	-	CTCTCT	rs62965461	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:66033519_66033520insCTCTCT	ENST00000546198.1	-	0	104																											GCTTTCTCTCGCTCTCTCTGac	0.446													5	4	---	---	---	---					
TPH2	121278	broad.mit.edu	37	12	72440554	72440554	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:72440554delT	ENST00000548885.1	-	0	462																											ttgctggggcttttttttttt	0.433													3	5	---	---	---	---					
RP1-34H18.1	0	broad.mit.edu	37	12	77877963	77877964	+	RNA	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:77877963_77877964insG	ENST00000550042.1	+	0	574																											AAGAAGGCAGAGGGGGCAGTGA	0.500													2	4	---	---	---	---					
RP11-328J6.1	0	broad.mit.edu	37	12	103526102	103526126	+	RNA	DEL	CTGGGGTCCTGAAATGGCTCCCTAA	CTGGGGTCCTGAAATGGCTCCCTAA	-	rs111481333		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:103526102_103526126delCTGGGGTCCTGAAATGGCTCCCTAA	ENST00000548594.1	-	0	167				RP11-328J6.1_ENST00000548415.1_RNA																							cagggcttggctggggtcctgaaatggctccctaacatgggaaaa	0.489													8	2	---	---	---	---					
RP4-601P9.2	0	broad.mit.edu	37	12	115200540	115200541	+	RNA	DEL	GT	GT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:115200540_115200541delGT	ENST00000551875.1	+	0	656																											gtgtgcgtgcgtgtgtgtgtgt	0.559													3	5	---	---	---	---					
RP11-148B3.2	0	broad.mit.edu	37	12	116820290	116820293	+	RNA	DEL	ACTC	ACTC	-	rs72358621		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:116820290_116820293delACTC	ENST00000548506.1	+	0	224																											acacgcacatactcacattagcgt	0.495													4	2	---	---	---	---					
RP11-357K6.3	0	broad.mit.edu	37	12	119292832	119292833	+	RNA	INS	-	-	AGAC	rs141961498	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:119292832_119292833insAGAC	ENST00000544515.1	-	0	447																											agagaggagagagagagagaga	0.470													2	4	---	---	---	---					
LOC100996671	100996671	broad.mit.edu	37	12	127157572	127157573	+	RNA	DEL	TG	TG	-	rs61941414	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr12:127157572_127157573delTG	ENST00000537478.1	-	0	234				RP11-407A16.4_ENST00000541769.1_lincRNA																							tgttttgttttgttttgtttgt	0.317													5	2	---	---	---	---					
TPTE2P6	374491	broad.mit.edu	37	13	25156885	25156888	+	RNA	DEL	GTGT	GTGT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:25156885_25156888delGTGT	ENST00000453498.1	+	0	473																											AAATATTGGGGTGTGTGTGTGTGT	0.343													2	4	---	---	---	---					
RP11-141M1.3	0	broad.mit.edu	37	13	34014408	34014408	+	RNA	DEL	A	A	-	rs663369	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:34014408delA	ENST00000454681.2	-	0	226																											agaacgaggcaaaaaaaaaaa	0.473													2	4	---	---	---	---					
LINC00598	646982	broad.mit.edu	37	13	41033203	41033218	+	RNA	DEL	AGGGAGAGAGGGAGGG	AGGGAGAGAGGGAGGG	-	rs11268012		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:41033203_41033218delAGGGAGAGAGGGAGGG	ENST00000400430.2	-	0	492																											GAAAAAAGAAagggagagagggagggagggagagag	0.444													4	6	---	---	---	---					
LINC00348	100885781	broad.mit.edu	37	13	71604068	71604069	+	RNA	INS	-	-	C	rs151041715	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:71604068_71604069insC	ENST00000428761.1	+	0	108					NR_047699.1																						atcaaattctgccctccagagg	0.416													5	1	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	78753491	78753491	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr13:78753491delT	ENST00000607862.1	+	0	230				RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000606803.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000606187.1_RNA|RNF219-AS1_ENST00000605996.1_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000560209.2_RNA																							ccccgcccccttttttttggt	0.393													2	4	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	27765327	27765328	+	RNA	INS	-	-	C	rs112978932	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:27765327_27765328insC	ENST00000553392.1	-	0	528																											ttctgccccagcccccccaaac	0.421													3	6	---	---	---	---					
RP11-966I7.3	0	broad.mit.edu	37	14	29288953	29288956	+	RNA	DEL	ACAC	ACAC	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:29288953_29288956delACAC	ENST00000549013.1	-	0	171																											agtgctcaagacacacacacacac	0.441													3	4	---	---	---	---					
LINC00639	283547	broad.mit.edu	37	14	39304293	39304298	+	RNA	DEL	CACACA	CACACA	-	rs5808014	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:39304293_39304298delCACACA	ENST00000553932.1	-	0	3985																											CGCCCTGCTCcacacacacacacaca	0.481													2	4	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43008556	43008557	+	RNA	DEL	GA	GA	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:43008556_43008557delGA	ENST00000557251.1	+	0	166																											tcacatattggagagagagaga	0.470													2	4	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43134143	43134146	+	RNA	DEL	AAAC	AAAC	-	rs113680573		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:43134143_43134146delAAAC	ENST00000557251.1	+	0	166																											tgctaactcaaaacaaacaaacaa	0.417													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44564150	44564150	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:44564150delA	ENST00000553827.1	-	0	69																											AGGTGCAAAGAAAAAAAAAGA	0.438													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44801158	44801158	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:44801158delA	ENST00000553827.1	-	0	69																											AGAATAAGTTAAATGCAAGGG	0.343													2	4	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46618442	46618446	+	RNA	DEL	TTTGT	TTTGT	-	rs139706144		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:46618442_46618446delTTTGT	ENST00000556886.1	+	0	58					NR_102701.1																						ccagcatctgtttgttttgttttgt	0.376													4	3	---	---	---	---					
LOC100506446	100506446	broad.mit.edu	37	14	50418492	50418492	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:50418492delT	ENST00000556913.1	-	0	339																											TATGAACATGTTTTTTTCCCC	0.393													3	5	---	---	---	---					
LOC101927598	101927598	broad.mit.edu	37	14	52261307	52261308	+	RNA	DEL	TT	TT	-	rs71121665		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:52261307_52261308delTT	ENST00000553312.1	+	0	1968																											CTACTGTATCTTTTTTTTTTTG	0.282													5	4	---	---	---	---					
DIO2-AS1	100628307	broad.mit.edu	37	14	80813021	80813021	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:80813021delA	ENST00000553979.1	+	0	178					NR_038355.1																						ATTACAAAATAACATATTTAG	0.393													2	4	---	---	---	---					
RP11-33N16.3	0	broad.mit.edu	37	14	90186526	90186526	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:90186526delT	ENST00000555070.1	-	0	170																											gatctgatggttttataaggg	0.507													2	4	---	---	---	---					
RP11-164H13.1	0	broad.mit.edu	37	14	96219291	96219292	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:96219291_96219292insT	ENST00000556386.1	+	0	326				RP11-164H13.1_ENST00000553445.1_RNA|RP11-164H13.1_ENST00000547644.2_RNA																							TTAATATTTTGTTTTTCCTTTG	0.426													2	4	---	---	---	---					
RP11-61O1.1	0	broad.mit.edu	37	14	98584472	98584472	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr14:98584472delC	ENST00000555776.1	-	0	121																											ACTGTTACTTCCATAGATCAT	0.333													2	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22307878	22307878	+	RNA	DEL	A	A	-	rs149075290		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:22307878delA	ENST00000558896.1	+	0	99																											tgttacaaacaatgcaattat	0.294													3	4	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	36006640	36006640	+	RNA	DEL	A	A	-	rs112186531		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:36006640delA	ENST00000501169.2	+	0	462					NR_038251.1																						aaaagaaaggaaaaaaaaaag	0.453													2	4	---	---	---	---					
RP11-624L4.1	0	broad.mit.edu	37	15	39625985	39625986	+	RNA	INS	-	-	TC	rs71917911		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:39625985_39625986insTC	ENST00000559318.1	-	0	408				RP11-624L4.1_ENST00000560484.1_RNA|RP11-624L4.1_ENST00000558209.1_RNA																							gtgtttgtctgtctctgtgtgt	0.391													3	6	---	---	---	---					
SORD2P	653381	broad.mit.edu	37	15	45120167	45120167	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:45120167delT	ENST00000561384.2	-	0	1023																											cctcccAttcttttttttttt	0.517													2	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48240127	48240128	+	RNA	DEL	CA	CA	-	rs57512482		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:48240127_48240128delCA	ENST00000560900.1	+	0	195				CTD-2007H18.1_ENST00000558370.1_lincRNA																							CGCGTacacgcacacacacaca	0.416													4	8	---	---	---	---					
RP11-548M13.1	0	broad.mit.edu	37	15	55375257	55375257	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:55375257delT	ENST00000569661.1	+	0	166																											ggtgttgacatttttttttta	0.368													2	4	---	---	---	---					
USP3-AS1	100130855	broad.mit.edu	37	15	63889045	63889046	+	RNA	INS	-	-	T	rs67198039	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:63889045_63889046insT	ENST00000560962.1	-	0	548				USP3-AS1_ENST00000559737.1_RNA|USP3-AS1_ENST00000561191.1_RNA|USP3-AS1_ENST00000558831.1_RNA|USP3-AS1_ENST00000561256.1_RNA|USP3-AS1_ENST00000560622.1_RNA																							TGGCACAAAAATAACAGGAATG	0.545													7	1	---	---	---	---					
RP11-665J16.1	0	broad.mit.edu	37	15	74462428	74462429	+	RNA	DEL	GC	GC	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:74462428_74462429delGC	ENST00000561647.1	-	0	71																											GTGTGTGTGTGCGCGCGcacac	0.530													6	2	---	---	---	---					
LINC00927	283688	broad.mit.edu	37	15	80562171	80562171	+	RNA	DEL	A	A	-	rs76164422		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:80562171delA	ENST00000558913.1	-	0	252					NR_033833.1																						CAGGATGCTGAAAAAAAAATC	0.423													3	6	---	---	---	---					
RP11-266O8.1	0	broad.mit.edu	37	15	93856823	93856846	+	RNA	DEL	CCTCCCTCCCTTCCTTCCTTCCTT	CCTCCCTCCCTTCCTTCCTTCCTT	-	rs72151927		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:93856823_93856846delCCTCCCTCCCTTCCTTCCTTCCTT	ENST00000543286.1	+	0	421																											tccctccctccctccctcccttccttccttccttccttccttcc	0.536													2	4	---	---	---	---					
NR2F2-AS1	644192	broad.mit.edu	37	15	96747448	96747449	+	RNA	INS	-	-	T	rs71874405	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:96747448_96747449insT	ENST00000559505.1	-	0	254				NR2F2-AS1_ENST00000560800.1_RNA																							tttgttttttgttttttttgtt	0.431													2	4	---	---	---	---					
NR2F2-AS1	644192	broad.mit.edu	37	15	96767550	96767550	+	RNA	DEL	C	C	-	rs35943386		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr15:96767550delC	ENST00000560800.1	-	0	220																											gcagtatgggcccaggtctct	0.527													2	4	---	---	---	---					
RP11-10K17.6	0	broad.mit.edu	37	16	5185716	5185716	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:5185716delT	ENST00000589323.1	+	0	451																											aggcatgaggttgaggcatga	0.517													2	4	---	---	---	---					
CTA-481E9.3	0	broad.mit.edu	37	16	18215654	18215657	+	RNA	DEL	GTTT	GTTT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:18215654_18215657delGTTT	ENST00000563866.1	-	0	48				CTA-481E9.4_ENST00000567304.1_lincRNA																							ACTGCTTATGgtttgtttgtttgt	0.402													4	5	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32031891	32031892	+	RNA	INS	-	-	G	rs138909480	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:32031891_32031892insG	ENST00000566806.1	-	0	499																											GAAAATGCCCAGGGGGGCCCAG	0.574													2	4	---	---	---	---					
RP11-142G1.3	0	broad.mit.edu	37	16	52233367	52233368	+	RNA	DEL	CA	CA	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:52233367_52233368delCA	ENST00000569998.1	-	0	61																											TTTacatacgcacacacacaca	0.455													3	5	---	---	---	---					
RP11-343H19.2	0	broad.mit.edu	37	16	56720566	56720567	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:56720566_56720567insA	ENST00000567563.1	+	0	321																											gaccctgtctcaaaaaacaaaa	0.520													2	4	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58937587	58937588	+	RNA	INS	-	-	T	rs11371466		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:58937587_58937588insT	ENST00000500117.1	+	0	679																											gggcatgcttcttttttttttt	0.490													4	2	---	---	---	---					
LOC101927580	101927580	broad.mit.edu	37	16	60049636	60049637	+	RNA	DEL	GA	GA	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:60049636_60049637delGA	ENST00000568279.1	+	0	173																											aaggaggcaggagagagagaga	0.480													2	4	---	---	---	---					
DPEP2	64174	broad.mit.edu	37	16	68026995	68026996	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:68026995_68026996insG	ENST00000412757.2	-	3	785_786	c.120_121insC	c.(118-123)ccgagcfs	p.S41fs	DPEP2_ENST00000572888.1_Frame_Shift_Ins_p.S41fs|DPEP2_ENST00000393847.1_Frame_Shift_Ins_p.S41fs			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	41					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		GTGAGGGCTCTGGGGGGGCCTG	0.678													2	4	---	---	---	---					
CTD-2009A10.1	0	broad.mit.edu	37	16	73579693	73579694	+	RNA	DEL	AA	AA	-	rs149606944		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:73579693_73579694delAA	ENST00000567227.1	+	0	68																											TGCTGaaattaaaaaaaaaaaa	0.371													3	3	---	---	---	---					
RP11-252E2.2	0	broad.mit.edu	37	16	75177780	75177780	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:75177780delG	ENST00000563098.1	+	0	397																											tcaaactcctgggctcaaggg	0.502													2	4	---	---	---	---					
CTD-2336H13.2	0	broad.mit.edu	37	16	76785787	76785787	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:76785787delA	ENST00000567777.1	+	0	138																											GTGTGAAATTATGCCATAGTG	0.473													2	4	---	---	---	---					
CTD-2336H13.2	0	broad.mit.edu	37	16	76842914	76842915	+	RNA	INS	-	-	A	rs138549379	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:76842914_76842915insA	ENST00000567777.1	+	0	138																											acgcagctgataaacagaccat	0.431													4	6	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80468018	80468018	+	RNA	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:80468018delC	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568776.1_RNA|RP11-525K10.3_ENST00000568819.1_RNA																							GCCTCTAGTTCCCAGATCCTG	0.453													5	3	---	---	---	---					
LOC100996425	100996425	broad.mit.edu	37	16	80923138	80923139	+	RNA	INS	-	-	TT	rs5818315		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:80923138_80923139insTT	ENST00000562231.1	-	0	91																											ttttggttttgttttttttttt	0.441													3	5	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81146182	81146183	+	RNA	INS	-	-	GAG			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr16:81146182_81146183insGAG	ENST00000533478.1	-	0	4828				PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						atgatgatgatgatgaggggga	0.480													2	4	---	---	---	---					
LOC101928475	101928475	broad.mit.edu	37	17	14923879	14923880	+	RNA	INS	-	-	A	rs34944906		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:14923879_14923880insA	ENST00000446671.1	+	0	54																											actaaaaatacaaaaaaaaaaa	0.460													4	3	---	---	---	---					
RP11-218F4.1	0	broad.mit.edu	37	17	26269053	26269054	+	RNA	DEL	GT	GT	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:26269053_26269054delGT	ENST00000567574.1	-	0	136																											ATCATGAGGGgtgtgtgtgtgt	0.446													2	4	---	---	---	---					
RP11-51L5.5	0	broad.mit.edu	37	17	60368374	60368374	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:60368374delA	ENST00000602493.1	-	0	273																											AGTAACAATTAAAAAAAAACT	0.289													3	5	---	---	---	---					
LINC00469	283982	broad.mit.edu	37	17	71767408	71767409	+	RNA	INS	-	-	TA			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:71767408_71767409insTA	ENST00000321800.7	-	0	211																											gtgtgtgtgtgtgtatgtgttt	0.475													4	2	---	---	---	---					
LOC101929650	101929650	broad.mit.edu	37	17	81102081	81102081	+	RNA	DEL	A	A	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr17:81102081delA	ENST00000572343.1	+	0	522																											CTCCCCAAGTAAAGTGGGGGC	0.622													2	4	---	---	---	---					
RP11-78F17.1	0	broad.mit.edu	37	18	982179	982180	+	RNA	INS	-	-	A	rs141412296	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:982179_982180insA	ENST00000580781.1	+	0	306																											caaccttctccggtctactcgc	0.480													4	5	---	---	---	---					
RP11-476K15.1	0	broad.mit.edu	37	18	1572469	1572470	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:1572469_1572470insA	ENST00000583163.1	+	0	114																											ttgattcagggaaaaatcatca	0.252													2	4	---	---	---	---					
ROCK1	6093	broad.mit.edu	37	18	18629104	18629105	+	Frame_Shift_Ins	INS	-	-	A	rs35810558		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:18629104_18629105insA	ENST00000399799.1	-	4	1302_1303	c.362_363insT	c.(361-363)ttgfs	p.L121fs		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	121	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TTTCTTCCCAGAAAAAAGCAGA	0.361													31	83	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22316059	22316061	+	RNA	DEL	GTG	GTG	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:22316059_22316061delGTG	ENST00000582650.1	+	0	235																											tgagtgtgttgtgtgtgtgtgtt	0.389													4	2	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37043504	37043504	+	RNA	DEL	A	A	-	rs141861299		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:37043504delA	ENST00000591629.1	-	0	440					NR_024391.1																						TCACTGAGGTAAAAAAAAAAA	0.308													3	4	---	---	---	---					
LINC01538	400654	broad.mit.edu	37	18	61918176	61918176	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:61918176delT	ENST00000588074.1	-	0	443				RP11-146N18.1_ENST00000589376.1_lincRNA	NR_033983.1																						TTGTTTTTTGTTTTTTTTTTT	0.363													3	4	---	---	---	---					
LOC284241	284241	broad.mit.edu	37	18	77409003	77409007	+	RNA	DEL	TCCTC	TCCTC	-	rs112616953	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr18:77409003_77409007delTCCTC	ENST00000317008.4	-	0	518																											AGTCCTGCTGTCCTCCCCTCTCCAG	0.668													2	4	---	---	---	---					
SMARCA4	6597	broad.mit.edu	37	19	11107209	11107209	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:11107209delC	ENST00000358026.2	+	11	2085	c.1801delC	c.(1801-1803)cgfs	p.P601fs	SMARCA4_ENST00000589677.1_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000444061.3_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000590574.1_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000429416.3_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000344626.4_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000450717.3_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000413806.3_Frame_Shift_Del_p.P601fs|SMARCA4_ENST00000541122.2_Frame_Shift_Del_p.P601fs	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	601					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TGCCATTGGGCCGGATGGCGA	0.507			"""F, N, Mis"""		NSCLC								45	91	---	---	---	---					
LOC100420587	100420587	broad.mit.edu	37	19	29059634	29059635	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:29059634_29059635insA	ENST00000592347.1	-	0	642				AC005616.1_ENST00000589999.1_RNA																							tcatatctactaaaaaacaaaa	0.510													2	4	---	---	---	---					
LOC100420587	100420587	broad.mit.edu	37	19	29072306	29072306	+	RNA	DEL	T	T	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:29072306delT	ENST00000592347.1	-	0	642				AC005616.1_ENST00000589999.1_RNA																							TAGAAGAGACTTTTTTTTTCC	0.488													2	4	---	---	---	---					
CTC-439O9.3	0	broad.mit.edu	37	19	31676010	31676011	+	RNA	INS	-	-	A	rs72109725		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:31676010_31676011insA	ENST00000589511.1	+	0	223																											gaaacaacaacaaaaaaaaaaa	0.446													3	4	---	---	---	---					
CEACAM20	125931	broad.mit.edu	37	19	45032185	45032192	+	RNA	DEL	TTCTTTTC	TTCTTTTC	-	rs112438515	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:45032185_45032192delTTCTTTTC	ENST00000454753.1	-	0	331							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				ttttctttctttcttttctttctttctt	0.385													2	4	---	---	---	---					
FLJ26850	400710	broad.mit.edu	37	19	50567905	50567906	+	RNA	DEL	GA	GA	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:50567905_50567906delGA	ENST00000527209.1	+	0	806					NR_027257.1																						gggttgtggggagagagagaga	0.446													2	4	---	---	---	---					
RPL23AP79	100271626	broad.mit.edu	37	19	59091278	59091279	+	RNA	INS	-	-	TTCC	rs10674364		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr19:59091278_59091279insTTCC	ENST00000493504.1	+	0	129					NR_026052.1																						CTCTATTttctttccttccttc	0.446													2	4	---	---	---	---					
RP11-103J8.1	0	broad.mit.edu	37	20	10823679	10823680	+	RNA	INS	-	-	A	rs73084798	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr20:10823679_10823680insA	ENST00000605292.1	+	0	98																											TGACAAAAAGGAAAAAAAAAGG	0.317													2	4	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21148198	21148198	+	RNA	DEL	G	G	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr20:21148198delG	ENST00000591761.1	-	0	5051				PLK1S1_ENST00000457464.1_RNA																							TGTTTGTTTCGCttttttttt	0.438													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11050147	11050147	+	RNA	DEL	G	G	-	rs60052903		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:11050147delG	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTTTTTTTTGATTACTGGAA	0.274													6	13	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11065702	11065703	+	RNA	INS	-	-	A	rs144462927		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:11065702_11065703insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		acacattacagaaaaaaaaatc	0.243													3	5	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11069158	11069158	+	RNA	DEL	T	T	-	rs57408407		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:11069158delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gaataatatattaaaaaaaac	0.284													3	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11069159	11069160	+	RNA	DEL	TA	TA	-	rs4009917	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:11069159_11069160delTA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aataatatattaaaaaaaactt	0.277													3	6	---	---	---	---					
LINC00649	100506334	broad.mit.edu	37	21	35318325	35318326	+	RNA	DEL	TG	TG	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:35318325_35318326delTG	ENST00000427447.1	+	0	669				LINC00649_ENST00000596365.1_RNA|LINC00649_ENST00000597626.1_RNA|LINC00649_ENST00000595747.1_RNA|LINC00649_ENST00000594752.1_RNA|LINC00649_ENST00000598119.1_RNA|LINC00649_ENST00000400353.2_RNA|LINC00649_ENST00000594370.1_RNA	NR_038883.1																						aacactccaatgtgtgtgtgtt	0.307													2	4	---	---	---	---					
LOC100133286	100133286	broad.mit.edu	37	21	37485932	37485933	+	RNA	INS	-	-	A	rs78022118	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr21:37485932_37485933insA	ENST00000535199.1	-	0	154					NR_040084.1																						aactctgactcaaaaaaaaaca	0.535													3	3	---	---	---	---					
LL22NC03-86D4.1	0	broad.mit.edu	37	22	34581387	34581388	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chr22:34581387_34581388insA	ENST00000412218.1	+	0	661																											aaatggattagaaaaaaaatga	0.307													2	4	---	---	---	---					
MID1	4281	broad.mit.edu	37	X	11045797	11045798	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:11045797_11045798insT	ENST00000433747.2	-	0	423																											tatgaaacctgtttttttttct	0.347													2	4	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22830097	22830097	+	RNA	DEL	A	A	-	rs11300602		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:22830097delA	ENST00000455399.1	-	0	178																											actccatctcaaaaaaaaaaa	0.423													2	4	---	---	---	---					
RP11-305F18.1	0	broad.mit.edu	37	X	33882017	33882018	+	RNA	INS	-	-	T			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:33882017_33882018insT	ENST00000439992.1	+	0	229																											TGTTTTTTAGCTTTTTTTTTCC	0.312													2	4	---	---	---	---					
RP1-154K9.2	0	broad.mit.edu	37	X	42305384	42305385	+	RNA	INS	-	-	A			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:42305384_42305385insA	ENST00000411879.1	+	0	452																											ccggttcccccaaaactattca	0.356													2	4	---	---	---	---					
LINC01420	550643	broad.mit.edu	37	X	56776900	56776901	+	RNA	INS	-	-	A	rs76134317		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:56776900_56776901insA	ENST00000374922.4	+	0	468					NR_015367.2																						ctgggttaaataaaaaaaatat	0.411													3	3	---	---	---	---					
LINC01278	92249	broad.mit.edu	37	X	62748649	62748650	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:62748649_62748650insC	ENST00000433061.1	-	0	218																											accctcccctaccccccagcag	0.525													2	4	---	---	---	---					
FAM155B	27112	broad.mit.edu	37	X	68725627	68725627	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:68725627delC	ENST00000252338.4	+	1	544	c.502delC	c.(502-504)ccfs	p.P169fs		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	169						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						CCCTCTGCGGCCCCCTGACTC	0.607													7	24	---	---	---	---					
RP5-1091N2.9	0	broad.mit.edu	37	X	70405940	70405941	+	RNA	INS	-	-	A	rs79117152		TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:70405940_70405941insA	ENST00000450860.1	-	0	267																											gactccgtctcaaaaaaaaaaa	0.480													3	3	---	---	---	---					
LINC00630	100287765	broad.mit.edu	37	X	102088960	102088961	+	RNA	INS	-	-	C			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:102088960_102088961insC	ENST00000440496.1	+	0	499					NR_038988.1																						tctcccctcttccccccatctc	0.351													2	4	---	---	---	---					
ACSL4	2182	broad.mit.edu	37	X	108871648	108871649	+	RNA	DEL	TC	TC	-			TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:108871648_108871649delTC	ENST00000439581.1	-	0	386																											ctctctcaaatctctctctctc	0.332													2	4	---	---	---	---					
GS1-256O22.5	0	broad.mit.edu	37	X	142594436	142594437	+	RNA	DEL	GC	GC	-	rs71966790	by1000genomes	TCGA-17-Z017-01A-01W-0746-08	TCGA-17-Z017-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37049bf1-55cb-44d3-b673-1e270ea835f7	9e803734-0ff2-4d47-a8ae-73998b48a10d	g.chrX:142594436_142594437delGC	ENST00000431432.1	+	0	268																											ttaaaatttggcgtgtgtgtgt	0.347													7	13	---	---	---	---					
