Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CALCRL	10203	broad.mit.edu	37	2	188217032	188217032	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:188217032C>G	ENST00000409998.1	-	14	1718	c.937G>C	c.(937-939)Gta>Cta	p.V313L	CALCRL_ENST00000410068.1_Missense_Mutation_p.V313L|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.V313L|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	313						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			AGAACGCGTACAATATTTAAC	0.338000													4	34					0	0	0.001984	0	0
NUP98	4928	broad.mit.edu	37	11	3707286	3707286	+	Silent	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:3707286T>C	ENST00000324932.7	-	29	5013	c.4593A>G	c.(4591-4593)ctA>ctG	p.L1531L	NUP98_ENST00000359171.4_Intron|NUP98_ENST00000355260.3_Intron	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1548					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AACTGGCCTGTAGCACACCTT	0.547000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								8	34					0	0	0.008291	0	0
ZNF592	9640	broad.mit.edu	37	15	85326375	85326375	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:85326375G>T	ENST00000299927.3	+	1	491	c.469G>T	c.(469-471)Gga>Tga	p.G157*	ZNF592_ENST00000560079.2_Nonsense_Mutation_p.G157*			Q92610	ZN592_HUMAN	zinc finger protein 592	157					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAAAGATAACGGATTTGGGAT	0.552000													37	177					8.16277e-20	1.60504e-19	0.006999	1	0
MTUS2	23281	broad.mit.edu	37	13	29599481	29599481	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:29599481C>A	ENST00000431530.3	+	1	734	c.676C>A	c.(676-678)Cca>Aca	p.P226T		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	216						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TGGGGAGGGGCCACAGAAGAC	0.602000													13	59					6.21321e-17	1.1629e-16	0.016522	1	0
CNOT7	29883	broad.mit.edu	37	8	17092352	17092352	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:17092352T>C	ENST00000361272.4	-	5	789	c.491A>G	c.(490-492)tAc>tGc	p.Y164C	CNOT7_ENST00000523917.1_Missense_Mutation_p.Y164C	NM_013354.5	NP_037486.2	Q9UIV1	CNOT7_HUMAN	CCR4-NOT transcription complex, subunit 7	164					carbohydrate metabolic process|nuclear-transcribed mRNA poly(A) tail shortening	CCR4-NOT complex|cytoplasmic mRNA processing body|cytosol	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)	11				Colorectal(111;0.0523)|COAD - Colon adenocarcinoma(73;0.209)		TTTGATTAAGTAGCCAAAGTC	0.308000													11	75					0	0	0.007413	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409860	105409860	+	Silent	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:105409860C>T	ENST00000333244.5	-	7	12047	c.11928G>A	c.(11926-11928)ccG>ccA	p.P3976P	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3976						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCGAACGACGGCATCTTGA	0.622000													5	78					0	0	0.014758	0	0
DNAH9	1770	broad.mit.edu	37	17	11840709	11840709	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:11840709A>G	ENST00000262442.3	+	66	12598	c.12530A>G	c.(12529-12531)tAt>tGt	p.Y4177C	DNAH9_ENST00000396001.2_Missense_Mutation_p.Y489C|DNAH9_ENST00000454412.2_Missense_Mutation_p.Y4101C	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4177					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCCTACCTCTATGGCCTCCAC	0.557000													8	39					0	0	0.003163	0	0
NLE1	54475	broad.mit.edu	37	17	33463440	33463440	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:33463440C>T	ENST00000586869.1	-	7	1048	c.29G>A	c.(28-30)cGc>cAc	p.R10H	NLE1_ENST00000442241.4_Missense_Mutation_p.R302H|NLE1_ENST00000360831.5_Missense_Mutation_p.R260H			Q9NVX2	NLE1_HUMAN	notchless homolog 1 (Drosophila)	302						nucleolus		p.R302H(1)		NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	22		Ovarian(249;0.17)				GGCCCCAGTGCGCAGGGCATA	0.602000													28	117					0	0	0.012213	0	0
QSER1	79832	broad.mit.edu	37	11	32954592	32954592	+	Silent	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:32954592A>G	ENST00000399302.2	+	4	1736	c.1401A>G	c.(1399-1401)acA>acG	p.T467T	QSER1_ENST00000527788.1_Intron	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	467	Ser-rich.									breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					AGTCCCTAACATTAACAGCCC	0.428000													16	50					0	0	0.008871	0	0
NUP37	79023	broad.mit.edu	37	12	102512139	102512139	+	Splice_Site	SNP	A	A	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:102512139A>C	ENST00000552283.1	-	2	296		c.e2+1		NUP37_ENST00000251074.1_Splice_Site|NUP37_ENST00000543021.1_Splice_Site			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa						carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						TTGTAGACTAACCTGAAACGT	0.363000													20	76					0	0	0.003954	0	0
FAT3	120114	broad.mit.edu	37	11	92570949	92570949	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:92570949G>T	ENST00000298047.6	+	16	10362	c.10345G>T	c.(10345-10347)Gcc>Tcc	p.A3449S	FAT3_ENST00000409404.2_Missense_Mutation_p.A3449S|FAT3_ENST00000525166.1_Missense_Mutation_p.A3299S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3449	Cadherin 32.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTTTACACCTGCCAACTATAC	0.463000										TCGA Ovarian(4;0.039)			18	62					3.28513e-13	5.80704e-13	0.003954	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33596042	33596042	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:33596042G>A	ENST00000504830.1	-	17	2986	c.2651C>T	c.(2650-2652)cCc>cTc	p.P884L	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P799L|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	884					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TGGTTACCTGGGTGGACAAGC	0.493000										HNSCC(64;0.19)			19	81					0	0	0.004656	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169707	207169707	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:207169707T>C	ENST00000374423.3	+	5	841	c.455T>C	c.(454-456)gTt>gCt	p.V152A		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	152							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTGGAGTTTGTTCATAAAATT	0.443000													7	36					0	0	0.006214	0	0
TEX15	56154	broad.mit.edu	37	8	30700805	30700805	+	Missense_Mutation	SNP	T	T	G	rs149415841	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:30700805T>G	ENST00000256246.2	-	1	5803	c.5729A>C	c.(5728-5730)cAa>cCa	p.Q1910P		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1910										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTCCTTCTTTTGTGAGTATTT	0.323000													17	59					0	0	0.006122	0	0
NHS	4810	broad.mit.edu	37	X	17739711	17739711	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:17739711G>T	ENST00000380060.3	+	4	1341	c.1003G>T	c.(1003-1005)Gcc>Tcc	p.A335S	NHS_ENST00000485305.1_3'UTR|NHS_ENST00000398097.3_Missense_Mutation_p.A179S	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	335						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					GAAACAAGATGCCCAAGTGAT	0.433000													24	174					8.58068e-18	1.65013e-17	0.007291	1	0
RAG2	5897	broad.mit.edu	37	11	36614854	36614854	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:36614854T>A	ENST00000311485.3	-	2	1026	c.865A>T	c.(865-867)Atc>Ttc	p.I289F		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	289					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				AAAGAGATGATGTTGCAGATC	0.393000									Familial Hemophagocytic Lymphohistiocytosis				13	70					0	0	0.002450	0	0
FBN2	2201	broad.mit.edu	37	5	127681174	127681174	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:127681174G>T	ENST00000508053.1	-	30	4066	c.3092C>A	c.(3091-3093)gCg>gAg	p.A1031E	FBN2_ENST00000508989.1_Missense_Mutation_p.A998E|FBN2_ENST00000262464.4_Missense_Mutation_p.A1031E			P35556	FBN2_HUMAN	fibrillin 2	1031	TB 5.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCCCCAAGCCGCCCCGACAGC	0.592000													20	53					3.73988e-18	7.27199e-18	0.006320	1	0
CYP2C19	1557	broad.mit.edu	37	10	96535174	96535174	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:96535174G>T	ENST00000371321.3	+	3	441	c.359G>T	c.(358-360)tGg>tTg	p.W120L	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	120			W -> R (in allele CYP2C19*8; loss of activity; dbSNP:rs41291556).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GGAAAGAGATGGAAGGAGATC	0.527000													44	142					5.78141e-17	1.0879e-16	0.013114	1	0
SLC22A18	5002	broad.mit.edu	37	11	2943331	2943331	+	Splice_Site	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:2943331G>C	ENST00000380574.1	+	9	1295		c.e9-1		SLC22A18_ENST00000449793.2_Splice_Site|SLC22A18_ENST00000312221.5_Splice_Site|SLC22A18_ENST00000347936.2_Splice_Site|SLC22A18_ENST00000441077.1_Splice_Site			Q96BI1	S22AI_HUMAN	solute carrier family 22, member 18						excretion|organic cation transport	apical plasma membrane|cytoplasmic part|integral to membrane|nuclear envelope	drug:hydrogen antiporter activity|symporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.192)		TCTGGCTCTAGGTGACCCAGG	0.667000													6	31					0	0	0.001984	0	0
MT-CO2	4513	broad.mit.edu	37	MT	8206	8206	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrM:8206G>A	ENST00000361739.1	+	1	621	c.621G>A	c.(619-621)atG>atA	p.M207I						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						CACAGTTTCATGCCCATCGTC	0.488000													11	1349					0	0	0.004482	0	0
CCDC30	728621	broad.mit.edu	37	1	43110454	43110454	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:43110454G>T	ENST00000428554.2	+	20	3009	c.1866G>T	c.(1864-1866)agG>agT	p.R622S	CCDC30_ENST00000340612.4_Missense_Mutation_p.R622S|CCDC30_ENST00000390640.4_Missense_Mutation_p.R411S|CCDC30_ENST00000342022.4_Missense_Mutation_p.R622S|CCDC30_ENST00000507855.1_Missense_Mutation_p.R411S			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	622										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						GAATTATAAGGAGCATCCATA	0.438000													17	22					2.98393e-07	3.92623e-07	0.016522	1	0
RNASEL	6041	broad.mit.edu	37	1	182554508	182554508	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:182554508G>A	ENST00000367559.3	-	2	1687	c.1434C>T	c.(1432-1434)tcC>tcT	p.S478S	RNASEL_ENST00000539397.1_Silent_p.S478S|RNASEL_ENST00000444138.1_Silent_p.S478S	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	478	Protein kinase.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						TGTATCCACAGGACAAGTGTA	0.423000													33	74					0	0	0.014410	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718580	103718580	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:103718580C>A	ENST00000245312.3	-	1	616	c.20G>T	c.(19-21)tGt>tTt	p.C7F		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	7					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATTGTCCACACAGCTGTTCGG	0.527000													31	121					2.75727e-19	5.39132e-19	0.004878	1	0
POF1B	79983	broad.mit.edu	37	X	84563198	84563198	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:84563198G>T	ENST00000262753.4	-	10	1127	c.982C>A	c.(982-984)Ctc>Atc	p.L328I	POF1B_ENST00000373145.3_Missense_Mutation_p.L328I	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	328							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						ACTAGTCGGAGTGACTTATCA	0.338000													8	23					4.68919e-08	6.3613e-08	0.008291	1	0
ZFHX4	79776	broad.mit.edu	37	8	77690624	77690624	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:77690624G>T	ENST00000521891.2	+	4	3722	c.3274G>T	c.(3274-3276)Gac>Tac	p.D1092Y	ZFHX4_ENST00000517683.1_3'UTR|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D1066Y|ZFHX4_ENST00000518282.1_Missense_Mutation_p.D1066Y|ZFHX4_ENST00000455469.2_Missense_Mutation_p.D1066Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1066						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCAGAGGAGGACAACCTCAG	0.527000										HNSCC(33;0.089)			37	140					2.00842e-17	3.82036e-17	0.010771	1	0
SCN3A	6328	broad.mit.edu	37	2	166018882	166018882	+	Splice_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:166018882C>A	ENST00000360093.3	-	9	1459		c.e9-1		SCN3A_ENST00000409101.3_Splice_Site|SCN3A_ENST00000283254.7_Splice_Site	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit							voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TAAAAGTGACCTGTTAATACA	0.289000													17	85					5.35267e-07	6.91304e-07	0.007413	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16848117	16848117	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:16848117C>A	ENST00000355661.3	-	10	903	c.893G>T	c.(892-894)cGg>cTg	p.R298L	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.R298L|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.R298L			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	298					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding	p.R298L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GACAGCCTGCCGCTCCACCTT	0.552000													8	12					1.5842e-08	2.26314e-08	0.001855	1	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	A	rs11554290		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:115256529T>A	ENST00000369535.4	-	3	435	c.182A>T	c.(181-183)cAa>cTa	p.Q61L		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			51	63					0	0	0.014410	0	0
CD177	57126	broad.mit.edu	37	19	43859868	43859868	+	RNA	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:43859868G>T	ENST00000378009.4	+	0	477				CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				GTCTGGAGGGGACAACAGAAG	0.592000													12	54					2.27111e-07	2.99958e-07	0.013537	1	0
FECH	2235	broad.mit.edu	37	18	55221585	55221585	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:55221585C>A	ENST00000262093.5	-	9	1135	c.984G>T	c.(982-984)aaG>aaT	p.K328N	FECH_ENST00000382873.3_Missense_Mutation_p.K334N	NM_000140.3|NM_001012515.2	NP_000131.2|NP_001012533.1	P22830	HEMH_HUMAN	ferrochelatase	328					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	15		Colorectal(73;0.227)				AGAGGATATTCTTCCTCCCCC	0.458000													17	84					0.000229342	0.000251629	0.012319	1	0
TACO1	51204	broad.mit.edu	37	17	61683704	61683704	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:61683704G>A	ENST00000258975.6	+	3	631	c.419G>A	c.(418-420)gGt>gAt	p.G140D		NM_016360.3	NP_057444.2	Q9BSH4	TACO1_HUMAN	translational activator of mitochondrially encoded cytochrome c oxidase I	140					regulation of translation	mitochondrion				breast(2)|endometrium(1)|lung(1)	4						CTGTATGAGGGTCGAGGCCCT	0.448000													30	93					0	0	0.009535	0	0
PREX1	57580	broad.mit.edu	37	20	47267458	47267458	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:47267458C>A	ENST00000396220.1	-	23	2813	c.2791G>T	c.(2791-2793)Ggc>Tgc	p.G931C	PREX1_ENST00000371941.3_Missense_Mutation_p.G931C			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	931					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			ATCCTCTGGCCAATGCTCTCC	0.602000													9	22					3.07112e-06	3.7982e-06	0.010729	1	0
TMEM55B	90809	broad.mit.edu	37	14	20927364	20927364	+	Splice_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:20927364C>A	ENST00000250489.4	-	6	977		c.e6+1		TMEM55B_ENST00000398020.4_Splice_Site|TMEM55B_ENST00000554028.1_Splice_Site			Q86T03	TM55B_HUMAN	transmembrane protein 55B							integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)	11	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		AGGGTACTCACGGCAAGGCCA	0.502000													19	49					4.72057e-08	6.37915e-08	0.003954	1	0
COL6A3	1293	broad.mit.edu	37	2	238280775	238280775	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:238280775C>A	ENST00000295550.4	-	9	4337	c.3885G>T	c.(3883-3885)gtG>gtT	p.V1295V	COL6A3_ENST00000346358.4_Silent_p.V1095V|COL6A3_ENST00000347401.3_Silent_p.V1094V|COL6A3_ENST00000353578.4_Silent_p.V1089V|COL6A3_ENST00000392004.3_Silent_p.V1089V|COL6A3_ENST00000472056.1_Silent_p.V688V|COL6A3_ENST00000409809.1_Silent_p.V1089V|COL6A3_ENST00000392003.2_Silent_p.V888V	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1295	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCGCGTTCTGCACTTCATCCT	0.612000													7	44					2.80697e-09	4.19847e-09	0.010729	1	0
KEAP1	9817	broad.mit.edu	37	19	10610244	10610244	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:10610244T>C	ENST00000171111.5	-	2	1013	c.466A>G	c.(466-468)Atg>Gtg	p.M156V	KEAP1_ENST00000393623.2_Missense_Mutation_p.M156V	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCACCGTTCATGACGTGGAGG	0.582000													8	20					0	0	0.013537	0	0
PAX4	5078	broad.mit.edu	37	7	127254935	127254935	+	Splice_Site	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:127254935C>T	ENST00000341640.2	-	2	540	c.336_splice	c.e2+1	p.S112_splice	PAX4_ENST00000463946.1_Splice_Site_p.S110_splice|PAX4_ENST00000378740.2_Splice_Site_p.S112_splice|PAX4_ENST00000338516.3_Splice_Site_p.S120_splice	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	120	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GGTACTTACACTGGGAGTCTT	0.547000													8	39					0	0	0.010729	0	0
NXPE2	120406	broad.mit.edu	37	11	114550400	114550400	+	Silent	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:114550400T>C	ENST00000375475.5	+	2	146	c.48T>C	c.(46-48)aaT>aaC	p.N16N	NXPE2_ENST00000389586.4_Silent_p.N16N					neurexophilin and PC-esterase domain family, member 2																		TGTTTCCAAATGCCATAGCTC	0.353000													7	13					0	0	0.006214	0	0
EXT1	2131	broad.mit.edu	37	8	118831993	118831993	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:118831993C>A	ENST00000378204.2	-	6	2264	c.1458G>T	c.(1456-1458)gcG>gcT	p.A486A		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	486			A -> V (in EXT1; no loss of activity).		glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			GGGGGGTCACCGCATGGATGA	0.512000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				28	104					8.91981e-05	0.000100708	0.015359	1	0
ESF1	51575	broad.mit.edu	37	20	13714431	13714431	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:13714431C>A	ENST00000202816.1	-	10	1994	c.1887G>T	c.(1885-1887)ctG>ctT	p.L629L		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	629	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						CCCAAGGGGTCAGTTTATCCT	0.318000													17	92					7.41877e-09	1.0819e-08	0.012319	1	0
IQCB1	9657	broad.mit.edu	37	3	121491545	121491545	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:121491545C>A	ENST00000310864.6	-	14	1640	c.1426G>T	c.(1426-1428)Gat>Tat	p.D476Y	IQCB1_ENST00000349820.6_Missense_Mutation_p.D343Y	NM_001023570.2	NP_001018864.2	Q15051	IQCB1_HUMAN	IQ motif containing B1	476					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding			NS(1)|biliary_tract(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)	30				GBM - Glioblastoma multiforme(114;0.0983)		CTGACCACATCTGACATTGGA	0.512000													45	176					8.94452e-30	1.90889e-29	0.014410	1	0
TRIP12	9320	broad.mit.edu	37	2	230654475	230654475	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:230654475C>T	ENST00000283943.5	-	30	4500	c.4322G>A	c.(4321-4323)gGa>gAa	p.G1441E	TRIP12_ENST00000389044.4_Missense_Mutation_p.G1489E|TRIP12_ENST00000389045.3_Missense_Mutation_p.G1171E	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1441					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGGGCACACTCCATCTAAAGG	0.388000													12	92					0	0	0.001855	0	0
FRMPD3	84443	broad.mit.edu	37	X	106793381	106793381	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:106793381G>T	ENST00000276185.4	+	7	604	c.604G>T	c.(604-606)Gtt>Ttt	p.V202F	FRMPD3_ENST00000477796.1_3'UTR			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	202	FERM.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						TCGGACCACTGTTAAGGTACA	0.473000													8	31					2.80697e-09	4.19847e-09	0.010729	1	0
SCN5A	6331	broad.mit.edu	37	3	38592784	38592784	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:38592784G>T	ENST00000413689.1	-	28	5272	c.5079C>A	c.(5077-5079)aaC>aaA	p.N1693K	SCN5A_ENST00000443581.1_Missense_Mutation_p.N1692K|SCN5A_ENST00000425664.1_Missense_Mutation_p.N1675K|SCN5A_ENST00000423572.2_Missense_Mutation_p.N1692K|SCN5A_ENST00000414099.2_Missense_Mutation_p.N1675K|SCN5A_ENST00000333535.4_Missense_Mutation_p.N1693K|SCN5A_ENST00000455624.2_Missense_Mutation_p.N1660K|SCN5A_ENST00000451551.2_Missense_Mutation_p.N1639K|SCN5A_ENST00000450102.2_Missense_Mutation_p.N1639K|SCN5A_ENST00000449557.2_Missense_Mutation_p.N1639K	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1693					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGTCTGGAAGTTGAACATGT	0.582000													44	223					1.51926e-22	3.09151e-22	0.014410	1	0
OVCH1	341350	broad.mit.edu	37	12	29604479	29604479	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:29604479C>A	ENST00000318184.5	-	22	2553	c.2554G>T	c.(2554-2556)Gaa>Taa	p.E852*	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	852	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CTAGGCTTTTCTAGCTCTGCT	0.438000													13	52					4.3838e-07	5.6827e-07	0.001855	1	0
KLHL3	26249	broad.mit.edu	37	5	137045461	137045461	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:137045461G>A	ENST00000508657.1	-	3	837	c.123C>T	c.(121-123)ccC>ccT	p.P41P	KLHL3_ENST00000394937.3_Silent_p.P73P|KLHL3_ENST00000309755.4_Silent_p.P73P	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	73						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CACAGAAGTAGGGGCTGCAGG	0.542000													14	34					0	0	0.004990	0	0
PCDH15	65217	broad.mit.edu	37	10	55582372	55582372	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:55582372G>A	ENST00000361849.3	-	34	5514	c.5120C>T	c.(5119-5121)cCt>cTt	p.P1707L	PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.P1705L|PCDH15_ENST00000395432.2_Missense_Mutation_p.P1665L|PCDH15_ENST00000395430.1_Missense_Mutation_p.P1702L|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395433.1_Missense_Mutation_p.P1682L|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.P1636L	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1705					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TAAAACACAAGGCCTTGAAGG	0.393000										HNSCC(58;0.16)			6	69					0	0	0.006214	0	0
POLR3E	55718	broad.mit.edu	37	16	22330235	22330235	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:22330235G>T	ENST00000299853.5	+	13	1121	c.954G>T	c.(952-954)gcG>gcT	p.A318A	POLR3E_ENST00000418581.2_Silent_p.A282A|POLR3E_ENST00000564209.1_Silent_p.A318A|POLR3E_ENST00000359210.4_Silent_p.A318A	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	318					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		AGAAGGTGGCGATGTTGGTCC	0.478000													14	42					1.05317e-09	1.63827e-09	0.002450	1	0
ALMS1	7840	broad.mit.edu	37	2	73675893	73675893	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:73675893C>T	ENST00000264448.6	+	8	2347	c.2236C>T	c.(2236-2238)Cct>Tct	p.P746S	ALMS1_ENST00000409009.1_Missense_Mutation_p.P704S|ALMS1_ENST00000377715.1_Missense_Mutation_p.P746S	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	746	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TTCAGCCACTCCTGGACCAGC	0.438000													57	242					0	0	0.014410	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905795	144905795	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:144905795C>A	ENST00000370490.1	+	1	6107	c.1852C>A	c.(1852-1854)Ctg>Atg	p.L618M	SLITRK2_ENST00000447897.2_Missense_Mutation_p.L618M|SLITRK2_ENST00000434188.2_Missense_Mutation_p.L618M|SLITRK2_ENST00000413937.2_Missense_Mutation_p.L618M|SLITRK2_ENST00000428560.2_Missense_Mutation_p.L618M			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	618						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAGTTCCACTGTCTGTCTT	0.448000													6	50					1.61879e-10	2.58711e-10	0.013537	1	0
ZNF234	10780	broad.mit.edu	37	19	44652983	44652983	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:44652983G>T	ENST00000426739.2	+	4	333	c.75G>T	c.(73-75)ctG>ctT	p.L25L	ZNF234_ENST00000592437.1_Silent_p.L25L	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				TGGGGCTGCTGGACCCTGTCC	0.488000													41	152					1.22674e-20	2.45349e-20	0.008740	1	0
PRUNE	58497	broad.mit.edu	37	1	150997258	150997258	+	Silent	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:150997258A>T	ENST00000271620.3	+	4	663	c.507A>T	c.(505-507)gcA>gcT	p.A169A	PRUNE_ENST00000368936.1_5'UTR|PRUNE_ENST00000368934.1_5'UTR|PRUNE_ENST00000368937.1_Intron|PRUNE_ENST00000271619.8_Intron|PRUNE_ENST00000368935.1_Intron|PRUNE_ENST00000467771.1_3'UTR	NM_021222.1	NP_067045.1	Q86TP1	PRUNE_HUMAN	prune exopolyphosphatase	169						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGCAAACTGCAGCCCTTCTGC	0.557000											OREG0013792	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	24					0	0	0.008871	0	0
DDX26B	203522	broad.mit.edu	37	X	134690115	134690115	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:134690115A>T	ENST00000370752.4	+	9	1416	c.1082A>T	c.(1081-1083)aAg>aTg	p.K361M	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	361										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					AGCAGTGGAAAGTACAATGAA	0.338000													17	86					0	0	0.004656	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783726	149783726	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:149783726G>A	ENST00000427880.2	-	1	199	c.153C>T	c.(151-153)ccC>ccT	p.P51P	HIST2H2BF_ENST00000469483.1_5'UTR|HIST2H2BF_ENST00000545683.1_Silent_p.P51P|HIST2H2BF_ENST00000369167.1_Silent_p.P51P			Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf	51					nucleosome assembly	nucleosome|nucleus	DNA binding	p.P51P(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)					TGCCGGTGTCGGGGTGGACCT	0.592000													7	333					0	0	0.006214	0	0
FAT3	120114	broad.mit.edu	37	11	92085981	92085981	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:92085981G>T	ENST00000298047.6	+	1	720	c.703G>T	c.(703-705)Gac>Tac	p.D235Y	FAT3_ENST00000541502.1_Missense_Mutation_p.D235Y|FAT3_ENST00000409404.2_Missense_Mutation_p.D235Y|FAT3_ENST00000525166.1_Missense_Mutation_p.D85Y			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	235	Cadherin 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTGGCTGTGGACCGGGGAAT	0.418000										TCGA Ovarian(4;0.039)			28	109					4.31634e-10	6.83583e-10	0.012213	1	0
SDK2	54549	broad.mit.edu	37	17	71334924	71334924	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:71334924C>A	ENST00000392650.3	-	45	6321	c.6321G>T	c.(6319-6321)tcG>tcT	p.S2107S	SDK2_ENST00000388726.3_Silent_p.S2088S|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2107					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CTGGCTCACCCGAGTCGCTCT	0.627000													8	28					6.42651e-13	1.11904e-12	0.010729	1	0
ZNF835	90485	broad.mit.edu	37	19	57175665	57175665	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:57175665G>T	ENST00000537055.2	-	2	1133	c.902C>A	c.(901-903)aCg>aAg	p.T301K		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CTTCTCGCCCGTGTGCACGCG	0.697000													5	14					3.09899e-07	4.03214e-07	0.004482	1	0
KLHL4	56062	broad.mit.edu	37	X	86869504	86869504	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:86869504C>A	ENST00000373119.4	+	3	803	c.658C>A	c.(658-660)Caa>Aaa	p.Q220K	KLHL4_ENST00000373114.4_Missense_Mutation_p.Q220K	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	220	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TGAAGCCAAACAAGAAGAGGT	0.378000													12	40					1.49906e-05	1.77854e-05	0.002450	1	0
STAB1	23166	broad.mit.edu	37	3	52539056	52539056	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:52539056C>T	ENST00000321725.6	+	13	1491	c.1415C>T	c.(1414-1416)aCg>aTg	p.T472M		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	472	FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCCCAGCAGACGTTCAACATC	0.592000													3	14					0	0	0.003080	0	0
CHIT1	1118	broad.mit.edu	37	1	203192352	203192352	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:203192352G>A	ENST00000367229.1	-	6	550	c.516C>T	c.(514-516)acC>acT	p.T172T	CHIT1_ENST00000484834.1_Intron|CHIT1_ENST00000255427.3_Silent_p.T153T|CHIT1_ENST00000535569.1_Silent_p.T163T	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	172					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity	p.T172T(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						CCTTCCCTGAGGTCTGGGCTT	0.612000													32	148					0	0	0.003755	0	0
TBC1D8	11138	broad.mit.edu	37	2	101666962	101666962	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:101666962A>G	ENST00000409318.1	-	5	903	c.773T>C	c.(772-774)gTc>gCc	p.V258A	TBC1D8_ENST00000376840.4_Missense_Mutation_p.V243A	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	243					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						CTGCTCCATGACCTTAAACAC	0.542000													4	7					0	0	0.014758	0	0
RPTN	126638	broad.mit.edu	37	1	152128369	152128369	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:152128369G>T	ENST00000316073.3	-	3	1270	c.1206C>A	c.(1204-1206)caC>caA	p.H402Q		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	402	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TCTGACCATAGTGAGAACTTT	0.502000													440	728					5.69969e-145	1.29538e-144	0.014410	1	0
BDKRB2	624	broad.mit.edu	37	14	96707170	96707170	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:96707170C>T	ENST00000542454.2	+	3	3512	c.424C>T	c.(424-426)Cgc>Tgc	p.R142C	BDKRB2_ENST00000539359.1_Missense_Mutation_p.R142C|BDKRB2_ENST00000306005.3_Missense_Mutation_p.R169C|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000554311.1_Missense_Mutation_p.R169C			P30411	BKRB2_HUMAN	bradykinin receptor B2	169					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GGGCCGGATGCGCGGCGTGCG	0.582000													26	66					0	0	0.006320	0	0
NUP160	23279	broad.mit.edu	37	11	47843375	47843375	+	Splice_Site	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:47843375T>A	ENST00000378460.2	-	9	1226		c.e9-2		NUP160_ENST00000528501.1_Splice_Site|NUP160_ENST00000528071.1_Splice_Site|NUP160_ENST00000530326.1_Splice_Site	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						CAGTGTCTCCTAGGAGGAAAT	0.393000													12	52					0	0	0.001855	0	0
ZP4	57829	broad.mit.edu	37	1	238048570	238048570	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:238048570G>T	ENST00000366570.4	-	9	1364	c.1206C>A	c.(1204-1206)gtC>gtA	p.V402V	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	402	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AGGCTTTCTGGACAGGGATCA	0.527000													19	49					2.70639e-06	3.37095e-06	0.014323	1	0
TSPEAR	54084	broad.mit.edu	37	21	45941862	45941862	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:45941862C>A	ENST00000323084.4	-	9	1535	c.1470G>T	c.(1468-1470)ctG>ctT	p.L490L	TSPEAR_ENST00000397916.1_Silent_p.L422L|C21orf90_ENST00000465978.1_Intron	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	490					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						TGGCCACCACCAGGAACGAGT	0.622000													9	29					2.80697e-09	4.19847e-09	0.010729	1	0
MEGF10	84466	broad.mit.edu	37	5	126778734	126778734	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:126778734G>C	ENST00000274473.6	+	20	2674	c.2407G>C	c.(2407-2409)Gat>Cat	p.D803H	MEGF10_ENST00000503335.2_Missense_Mutation_p.D803H	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	803	EGF-like 15.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CCAGATATGTGATTGTCTGAA	0.488000													8	26					0	0	0.004482	0	0
SOCS6	9306	broad.mit.edu	37	18	67992072	67992072	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:67992072C>A	ENST00000397942.3	+	2	484	c.168C>A	c.(166-168)atC>atA	p.I56I	SOCS6_ENST00000582322.1_Silent_p.I56I	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	56					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GCTGCGATATCAACGGTGAAG	0.428000													11	55					1.5842e-08	2.26314e-08	0.001855	1	0
C20orf196	149840	broad.mit.edu	37	20	5844057	5844057	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:5844057C>T	ENST00000303142.6	+	3	653	c.566C>T	c.(565-567)tCa>tTa	p.S189L		NM_152504.2	NP_689717.2	Q8IYI0	CT196_HUMAN	chromosome 20 open reading frame 196	189										endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)	9						CCAGGACTGTCAAAGGATATT	0.498000													17	77					0	0	0.004656	0	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709666	22709666	+	RNA	SNP	T	T	G	rs4369632		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:22709666T>G	ENST00000314246.8	-	0	1118																											CCTCTCCAGCTTCTCTACCCG	0.557000													5	99					0	0	0.001168	0	0
UBR4	23352	broad.mit.edu	37	1	19518818	19518818	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:19518818G>T	ENST00000375267.2	-	11	1261	c.1258C>A	c.(1258-1260)Ctc>Atc	p.L420I	UBR4_ENST00000375254.3_Missense_Mutation_p.L420I|UBR4_ENST00000375217.2_Missense_Mutation_p.L420I|UBR4_ENST00000375226.2_Missense_Mutation_p.L420I			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	420					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTCAGTATGAGGAAAAGGCTG	0.433000													4	120					0.014758	0.015192	0.014758	1	0
MT-ND1	4535	broad.mit.edu	37	MT	3707	3707	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrM:3707G>A	ENST00000361390.2	+	1	401	c.401G>A	c.(400-402)cGa>cAa	p.134_134insQ						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						CGGCGCACTGCGAGCAGTAGC	0.468000													277	1147					0	0	0.014410	0	0
PRAF2	11230	broad.mit.edu	37	X	48930132	48930132	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:48930132G>A	ENST00000376390.4	-	2	440	c.357C>T	c.(355-357)ggC>ggT	p.G119G	WDR45_ENST00000553851.1_Silent_p.G233G|PRAF2_ENST00000376386.3_Silent_p.G119G|WDR45_ENST00000376358.3_Silent_p.G233G|PRAF2_ENST00000491199.1_Intron	NM_007213.1	NP_009144.1			PRA1 domain family, member 2											endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	8						AGGTGCAAGCGCCGCCCGCGA	0.687000													3	5					0	0	0.009096	0	0
KCNS2	3788	broad.mit.edu	37	8	99441275	99441275	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:99441275G>A	ENST00000287042.4	+	2	1418	c.1068G>A	c.(1066-1068)gaG>gaA	p.E356E	KCNS2_ENST00000521839.1_Silent_p.E356E	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	356						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			AGGAGAACGAGGGCCTGGCCA	0.577000													4	27					0	0	0.006214	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73070953	73070953	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:73070953G>T	ENST00000263674.3	+	10	4512	c.4162G>T	c.(4162-4164)Ggc>Tgc	p.G1388C		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1388					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CACCACCCTGGGCCAAATGAG	0.617000													11	10					5.50884e-06	6.69477e-06	0.013537	1	0
MYT1L	23040	broad.mit.edu	37	2	1842979	1842979	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:1842979G>T	ENST00000399161.2	-	21	3769	c.3022C>A	c.(3022-3024)Ccc>Acc	p.P1008T	MYT1L_ENST00000471668.1_5'UTR|MYT1L_ENST00000407844.1_Missense_Mutation_p.P4T|MYT1L_ENST00000428368.2_Missense_Mutation_p.P1006T	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1008					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P1008T(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CCTGGCGTGGGGCAGGACATG	0.672000													4	7					1.23904e-05	1.48008e-05	0.014758	1	0
PRIM2	5558	broad.mit.edu	37	6	57398204	57398204	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:57398204C>A	ENST00000607273.1	+	10	994	c.907C>A	c.(907-909)Cat>Aat	p.H303N	PRIM2_ENST00000389488.2_3'UTR	NM_000947.2	NP_000938.2	P49643	PRI2_HUMAN	primase, DNA, polypeptide 2 (58kDa)	303					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CCATCTTTGTCATGGAGGCCG	0.388000													7	201					2.23348e-06	2.79186e-06	0.004007	1	0
EPB42	2038	broad.mit.edu	37	15	43500962	43500962	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:43500962G>C	ENST00000300215.3	-	7	1391	c.934C>G	c.(934-936)Ctg>Gtg	p.L312V	EPB42_ENST00000540029.1_Missense_Mutation_p.L204V|EPB42_ENST00000441366.2_Missense_Mutation_p.L282V			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	282					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GGGATTCCCAGGCATCGCAGC	0.597000													5	28					0	0	0.001168	0	0
PCDH17	27253	broad.mit.edu	37	13	58299215	58299215	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:58299215C>A	ENST00000377918.3	+	4	3293	c.3267C>A	c.(3265-3267)ccC>ccA	p.P1089P		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1089					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GAGACCCTCCCTTCATGGCTT	0.532000													39	118					3.77016e-25	7.80802e-25	0.013114	1	0
CNTN1	1272	broad.mit.edu	37	12	41419071	41419071	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:41419071C>A	ENST00000551295.2	+	21	2760	c.2643C>A	c.(2641-2643)gtC>gtA	p.V881V	CNTN1_ENST00000348761.2_Silent_p.V870V|CNTN1_ENST00000347616.1_Silent_p.V881V|CNTN1_ENST00000550305.1_3'UTR	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	881	Fibronectin type-III 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTATAGAAGTCGGGGCCTGCA	0.478000													66	298					2.72615e-36	5.92642e-36	0.014410	1	0
KCNK2	3776	broad.mit.edu	37	1	215345469	215345469	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:215345469G>C	ENST00000444842.2	+	5	916	c.766G>C	c.(766-768)Gcc>Ccc	p.A256P	KCNK2_ENST00000391894.2_Missense_Mutation_p.A241P|KCNK2_ENST00000391895.2_Missense_Mutation_p.A252P	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	256							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TGCCCTGGACGCCATTTATTT	0.418000													40	94					0	0	0.014410	0	0
ALDH3B2	222	broad.mit.edu	37	11	67433012	67433012	+	Silent	SNP	G	G	A	rs142189245	byFrequency	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:67433012G>A	ENST00000349015.3	-	7	888	c.450C>T	c.(448-450)cgC>cgT	p.R150R	ALDH3B2_ENST00000530069.1_Silent_p.R150R	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	150					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	ACCAGGCCACGCGGTTGGCCA	0.672000													4	120					0	0	0.009096	0	0
JADE3	9767	broad.mit.edu	37	X	46898443	46898443	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:46898443G>T	ENST00000218343.4	+	8	1246	c.948G>T	c.(946-948)aaG>aaT	p.K316N	PHF16_ENST00000397189.1_Missense_Mutation_p.K316N	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		316					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						ACTTGTGCAAGTTGAAGACGG	0.522000													16	60					2.23348e-06	2.79186e-06	0.004007	1	0
NEO1	4756	broad.mit.edu	37	15	73575342	73575342	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:73575342G>T	ENST00000339362.5	+	24	3747	c.3300G>T	c.(3298-3300)ctG>ctT	p.L1100L	NEO1_ENST00000261908.6_Silent_p.L1100L|NEO1_ENST00000558964.1_Silent_p.L1089L|NEO1_ENST00000560262.1_Silent_p.L1100L			Q92859	NEO1_HUMAN	neogenin 1	1100					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						CCTCTCCTCTGGACAGTAATA	0.468000													86	272					6.21051e-42	1.35855e-41	0.014410	1	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362155	105362155	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:105362155G>T	ENST00000369774.4	-	15	3096	c.2820C>A	c.(2818-2820)aaC>aaA	p.N940K	SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.N807K|SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.N912K|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000427662.2_Intron|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.N775K			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	940					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TCTTGCTCTGGTTGACGGTGT	0.622000													8	56					0.00010058	0.00011247	0.013537	1	0
HDAC9	9734	broad.mit.edu	37	7	18688152	18688152	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:18688152G>T	ENST00000406451.3	+	11	1454	c.1304G>T	c.(1303-1305)aGa>aTa	p.R435I	HDAC9_ENST00000441542.2_Missense_Mutation_p.R438I|HDAC9_ENST00000406072.1_Missense_Mutation_p.R422I|HDAC9_ENST00000432645.2_Missense_Mutation_p.R435I|HDAC9_ENST00000401921.1_Missense_Mutation_p.R394I|HDAC9_ENST00000456174.2_Missense_Mutation_p.R407I|HDAC9_ENST00000524023.1_Missense_Mutation_p.R358I|HDAC9_ENST00000417496.2_Missense_Mutation_p.R433I|HDAC9_ENST00000428307.2_Missense_Mutation_p.R391I|HDAC9_ENST00000405010.3_Missense_Mutation_p.R435I	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	435					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCTGGCATTAGAGGTACCCAC	0.473000													27	147					9.65021e-13	1.65567e-12	0.010818	1	0
GRIA2	2891	broad.mit.edu	37	4	158224935	158224935	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:158224935G>A	ENST00000296526.7	+	3	786	c.461G>A	c.(460-462)aGt>aAt	p.S154N	GRIA2_ENST00000507898.1_Missense_Mutation_p.S107N|GRIA2_ENST00000393815.2_Missense_Mutation_p.S107N|GRIA2_ENST00000264426.9_Missense_Mutation_p.S154N|GRIA2_ENST00000449365.1_Missense_Mutation_p.S107N	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	154					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CTCTATGACAGTGACAGAGGT	0.413000													4	229					0	0	0.001168	0	0
FRG1B	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	152					0	0	0.009096	0	0
SON	6651	broad.mit.edu	37	21	34924840	34924840	+	Silent	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:34924840G>C	ENST00000356577.4	+	3	3778	c.3303G>C	c.(3301-3303)cgG>cgC	p.R1101R	SON_ENST00000300278.4_Silent_p.R1101R|SON_ENST00000290239.6_Silent_p.R1101R|SON_ENST00000381679.4_Silent_p.R1101R|SON_ENST00000381692.2_Intron	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1101	14 X 6 AA repeats of [ED]-R-S-M-M-S.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						CTGCTGACCGGTCTATGATGT	0.473000													5	43					0	0	0.001984	0	0
GUCY2F	2986	broad.mit.edu	37	X	108673616	108673616	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:108673616C>A	ENST00000218006.2	-	8	2002	c.1711G>T	c.(1711-1713)Gtg>Ttg	p.V571L		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	571	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						TTCAGCCACACCCAATCACCC	0.388000													80	330					3.60193e-44	7.97895e-44	0.014410	1	0
TBL2	26608	broad.mit.edu	37	7	72985127	72985127	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:72985127T>C	ENST00000305632.5	-	7	1295	c.1054A>G	c.(1054-1056)Agt>Ggt	p.S352G	TBL2_ENST00000432538.1_Missense_Mutation_p.S316G|TBL2_ENST00000459913.1_5'UTR	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	352										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGAATACTACTGCCACTGGCC	0.617000													4	20					0	0	0.010729	0	0
UTP20	27340	broad.mit.edu	37	12	101679536	101679536	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:101679536A>G	ENST00000261637.4	+	4	377	c.203A>G	c.(202-204)tAc>tGc	p.Y68C		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	68					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GGAAAATTTTACAAAGAAGTT	0.343000													15	51					0	0	0.010504	0	0
KIAA1958	158405	broad.mit.edu	37	9	115337360	115337360	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:115337360G>C	ENST00000337530.6	+	2	1296	c.1000G>C	c.(1000-1002)Gat>Cat	p.D334H	KIAA1958_ENST00000536272.1_Missense_Mutation_p.D334H|KIAA1958_ENST00000374244.3_Missense_Mutation_p.D334H	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	334										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						GCCTGGACAGGATGAGCAAGT	0.547000													44	134					0	0	0.014410	0	0
DCHS1	8642	broad.mit.edu	37	11	6647528	6647528	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:6647528C>A	ENST00000299441.3	-	16	6859	c.6448G>T	c.(6448-6450)Gga>Tga	p.G2150*		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2150	Cadherin 20.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G2150R(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAAAGGCTCCTCCACTCTCT	0.592000													7	14					3.09899e-07	4.03214e-07	0.004482	1	0
RC3H2	54542	broad.mit.edu	37	9	125620998	125620998	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:125620998C>A	ENST00000373670.1	-	11	2833	c.2233G>T	c.(2233-2235)Gtg>Ttg	p.V745L	RC3H2_ENST00000423239.2_Missense_Mutation_p.V745L|RC3H2_ENST00000357244.2_Missense_Mutation_p.V745L			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	745						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGACAAGCCACCGAATAATAT	0.418000													11	16					0.000219431	0.000241513	0.002450	1	0
LILRA1	11024	broad.mit.edu	37	19	55106759	55106759	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:55106759G>T	ENST00000453777.1	+	5	723	c.553G>T	c.(553-555)Ggc>Tgc	p.G185C	LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.G185C|LILRB1_ENST00000396321.2_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	185	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CTTCTCTGTGGGCCCCGTGAG	0.572000													23	64					2.27731e-05	2.65686e-05	0.012319	1	0
MIR892A	100126342	broad.mit.edu	37	X	145078225	145078225	+	RNA	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:145078225G>T	ENST00000401124.1	-	0	36					NR_030584.1																						GTGACATGTAGTGTAAGTGAC	0.517000													29	222					2.09667e-21	4.24181e-21	0.003755	1	0
FBXL7	23194	broad.mit.edu	37	5	15928552	15928552	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:15928552C>A	ENST00000504595.1	+	3	1162	c.681C>A	c.(679-681)aaC>aaA	p.N227K	FBXL7_ENST00000329673.7_Missense_Mutation_p.N215K|FBXL7_ENST00000510662.1_Missense_Mutation_p.N180K	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	227					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						ATATCTCCAACGAGGCCGTCT	0.587000													29	102					1.55811e-20	3.09851e-20	0.008361	1	0
KCNU1	157855	broad.mit.edu	37	8	36721970	36721970	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:36721970G>T	ENST00000399881.3	+	19	1977	c.1940G>T	c.(1939-1941)cGt>cTt	p.R647L		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	647						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATCTCCTCTCGTATATCAGGG	0.458000													34	158					4.32679e-17	8.18582e-17	0.006999	1	0
IQGAP3	128239	broad.mit.edu	37	1	156510566	156510566	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:156510566C>A	ENST00000361170.2	-	23	2683	c.2673G>T	c.(2671-2673)ctG>ctT	p.L891L		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	891					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGTCCTGCTCCAGCTGCTGAT	0.547000													48	60					5.57489e-27	1.17543e-26	0.014410	1	0
PEG3	5178	broad.mit.edu	37	19	57333080	57333080	+	Missense_Mutation	SNP	G	G	T	rs145933493	byFrequency	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:57333080G>T	ENST00000326441.9	-	7	971	c.608C>A	c.(607-609)aCa>aAa	p.T203K	ZIM2_ENST00000601070.1_Missense_Mutation_p.T78K|PEG3_ENST00000423103.2_Missense_Mutation_p.T203K|PEG3_ENST00000593695.1_Missense_Mutation_p.T77K|ZIM2_ENST00000391708.3_Missense_Mutation_p.T78K|ZIM2_ENST00000593711.1_Missense_Mutation_p.T78K|ZIM2_ENST00000221722.5_Missense_Mutation_p.T78K|ZIM2_ENST00000599935.1_Missense_Mutation_p.T78K|PEG3_ENST00000598410.1_Missense_Mutation_p.T78K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	203					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCAAAGCTTGTTTTCGCCAC	0.532000													47	158					2.01872e-29	4.28212e-29	0.014410	1	0
MYBL1	4603	broad.mit.edu	37	8	67492484	67492484	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:67492484G>T	ENST00000522677.3	-	9	1395	c.985C>A	c.(985-987)Cct>Act	p.P329T	MYBL1_ENST00000524176.2_Missense_Mutation_p.P329T|MYBL1_ENST00000517885.1_Intron	NM_001080416.2|NM_001144755.1	NP_001073885.1|NP_001138227.1	P10243	MYBA_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 1	329	Negative regulatory domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|skin(1)	25			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			GCAGACACAGGCTGATTTTCA	0.453000													15	36					6.49762e-13	1.12583e-12	0.006122	1	0
MUC16	94025	broad.mit.edu	37	19	9000568	9000568	+	Splice_Site	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:9000568T>A	ENST00000397910.4	-	54	40621		c.e54-2		MUC16_ENST00000380951.5_Splice_Site	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCTGGCGGCTATAGTGAAGA	0.388000													53	124					0	0	0.014410	0	0
LSM14B	149986	broad.mit.edu	37	20	60706504	60706504	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:60706504T>A	ENST00000253001.4	+	7	1134	c.928T>A	c.(928-930)Tgc>Agc	p.C310S	LSM14B_ENST00000279068.6_Missense_Mutation_p.C310S			Q9BX40	LS14B_HUMAN	LSM14B, SCD6 homolog B (S. cerevisiae)	310					multicellular organismal development|regulation of translation	ribonucleoprotein complex				endometrium(3)|kidney(1)|lung(4)	8	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GGGGCCCAACTGCTACTATGA	0.527000													3	8					0	0	0.001984	0	0
PPT2-EGFL8	100532746	broad.mit.edu	37	6	32122496	32122496	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:32122496T>A	ENST00000422437.1	+	2	316	c.125T>A	c.(124-126)gTg>gAg	p.V42E	PPT2_ENST00000361568.2_Missense_Mutation_p.V48E|PPT2_ENST00000324816.6_Missense_Mutation_p.V42E|PPT2-EGFL8_ENST00000453656.2_3'UTR|PPT2_ENST00000395523.1_Missense_Mutation_p.V42E|PPT2_ENST00000375137.2_Missense_Mutation_p.V42E|PPT2_ENST00000445576.2_Missense_Mutation_p.V42E|PPT2_ENST00000493548.1_3'UTR|PPT2_ENST00000375143.2_Missense_Mutation_p.V42E|PPT2_ENST00000437001.2_5'UTR																							GTCATCGTGGTGCATGGGCTC	0.652000													9	39					0	0	0.007413	0	0
NKAIN2	154215	broad.mit.edu	37	6	124979589	124979589	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:124979589T>A	ENST00000368416.1	+	4	591	c.531T>A	c.(529-531)tgT>tgA	p.C177*	NKAIN2_ENST00000368417.1_Intron|NKAIN2_ENST00000546092.1_Intron|NKAIN2_ENST00000545433.1_Intron			Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	4						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		TTTATTTCTGTGCGAACTCAG	0.448000													12	46					0	0	0.002450	0	0
PLCB1	23236	broad.mit.edu	37	20	8628575	8628575	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:8628575C>A	ENST00000378641.3	+	6	968	c.493C>A	c.(493-495)Cca>Aca	p.P165T	PLCB1_ENST00000378637.2_Missense_Mutation_p.P165T|PLCB1_ENST00000338037.6_Missense_Mutation_p.P165T	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	165					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GCAAGTCACTCCAGAAGGGCG	0.333000													9	47					4.7546e-09	7.08133e-09	0.004007	1	0
VTN	7448	broad.mit.edu	37	17	26697216	26697216	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:26697216G>T	ENST00000226218.4	-	1	627	c.9C>A	c.(7-9)ccC>ccA	p.P3P	SARM1_ENST00000379061.4_Intron|CTB-96E2.3_ENST00000591482.1_RNA|SEBOX_ENST00000536498.1_5'UTR|TMEM199_ENST00000509083.1_Intron	NM_000638.3	NP_000629.3	P04004	VTNC_HUMAN	vitronectin	3					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			kidney(2)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	13	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	GGGGTCTCAGGGGTGCCATGG	0.617000													5	16					0.000157383	0.000173767	0.003080	1	0
HPSE2	60495	broad.mit.edu	37	10	100374754	100374754	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:100374754C>A	ENST00000370552.3	-	9	1286	c.1227G>T	c.(1225-1227)atG>atT	p.M409I	HPSE2_ENST00000370546.1_Missense_Mutation_p.M409I|HPSE2_ENST00000404542.1_Missense_Mutation_p.M297I|HPSE2_ENST00000370549.1_Missense_Mutation_p.M351I	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	409					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GATTGGCCAGCATTCCTAAAG	0.388000													21	163					3.08376e-08	4.35208e-08	0.003330	1	0
FLG	2312	broad.mit.edu	37	1	152277156	152277156	+	Silent	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:152277156C>T	ENST00000368799.1	-	3	10241	c.10206G>A	c.(10204-10206)cgG>cgA	p.R3402R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3402	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTCCTGGTCCGCCCATGGG	0.602000									Ichthyosis				102	162					0	0	0.014410	0	0
SGK223	157285	broad.mit.edu	37	8	8185691	8185691	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:8185691C>A	ENST00000520004.1	-	5	2865	c.2601G>T	c.(2599-2601)ggG>ggT	p.G867G	SGK223_ENST00000330777.4_Silent_p.G867G			Q86YV5	SG223_HUMAN		867							ATP binding|non-membrane spanning protein tyrosine kinase activity										GGTGGCGGTTCCCGGGGCTCA	0.592000													18	84					6.00712e-18	1.1616e-17	0.012213	1	0
LAMA2	3908	broad.mit.edu	37	6	129674499	129674499	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:129674499G>T	ENST00000421865.2	+	32	4763	c.4714G>T	c.(4714-4716)Gtt>Ttt	p.V1572F		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1572	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGGGAGTGTGTTTGTACGTA	0.532000													10	41					4.68919e-08	6.3613e-08	0.008291	1	0
RUVBL2	10856	broad.mit.edu	37	19	49510571	49510571	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:49510571G>C	ENST00000413176.2	+	6	1421	c.273G>C	c.(271-273)gaG>gaC	p.E91D	RUVBL2_ENST00000601968.1_Missense_Mutation_p.E91D|RUVBL2_ENST00000595090.1_Missense_Mutation_p.E136D			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	136					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGGAGACGGAGATCATCGAAG	0.587000													3	13					0	0	0.001984	0	0
USP44	84101	broad.mit.edu	37	12	95914952	95914952	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:95914952T>G	ENST00000258499.3	-	5	2048	c.1760A>C	c.(1759-1761)aAg>aCg	p.K587T	USP44_ENST00000393091.2_Missense_Mutation_p.K587T|USP44_ENST00000552440.1_Intron|USP44_ENST00000537435.2_Missense_Mutation_p.K587T	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	587					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						AACACCAATCTTCTCTCGGTT	0.423000													15	86					0	0	0.006122	0	0
VPS39	23339	broad.mit.edu	37	15	42454305	42454305	+	Silent	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:42454305C>T	ENST00000318006.5	-	23	2547	c.2385G>A	c.(2383-2385)aaG>aaA	p.K795K	VPS39_ENST00000348544.4_Silent_p.K806K	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	806					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CTTCCAAGACCTTTTCCAGGA	0.473000													9	40					0	0	0.010729	0	0
ACOXL	55289	broad.mit.edu	37	2	111789245	111789245	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:111789245G>T	ENST00000389811.4	+	16	1637	c.1413G>T	c.(1411-1413)tcG>tcT	p.S471S	ACOXL_ENST00000439055.1_Silent_p.S441S			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	471					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CCTGGAACTCGTGTCTGCACC	0.468000													15	48					8.28177e-16	1.52559e-15	0.007413	1	0
MUC3A	4584	broad.mit.edu	37	7	100551592	100551592	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:100551592C>A	ENST00000319509.7	+	1	343	c.343C>A	c.(343-345)Cca>Aca	p.P115T						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGAGAACACCCCAATCAGTTC	0.502000													9	82					0.00010058	0.00011247	0.013537	1	0
PDZD7	79955	broad.mit.edu	37	10	102783726	102783726	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:102783726A>G	ENST00000370215.3	-	3	551	c.326T>C	c.(325-327)cTg>cCg	p.L109P	PDZD7_ENST00000470414.1_Missense_Mutation_p.L109P	NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	109	PDZ 1.					cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		GAAGATGCCCAGGCCATGCTC	0.572000													13	87					0	0	0.002450	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408755	105408755	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:105408755G>C	ENST00000333244.5	-	7	13152	c.13033C>G	c.(13033-13035)Cac>Gac	p.H4345D	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4345						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATGCTGAGGTGAGTGGTCTTC	0.627000													3	49					0	0	0.004672	0	0
MMP27	64066	broad.mit.edu	37	11	102573850	102573850	+	Splice_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:102573850C>A	ENST00000260229.4	-	3	433		c.e3-1			NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27						collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GTTTATTATTCTTAAAAATTA	0.348000													5	31					2.0095e-06	2.52994e-06	0.001984	1	0
SERPINA5	5104	broad.mit.edu	37	14	95058481	95058481	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:95058481C>A	ENST00000329597.7	+	6	1336	c.1126C>A	c.(1126-1128)Cgc>Agc	p.R376S	SERPINA3_ENST00000553947.1_Intron|SERPINA5_ENST00000554866.1_Missense_Mutation_p.R376S|SERPINA5_ENST00000553780.1_Missense_Mutation_p.R376S|SERPINA5_ENST00000554276.1_Missense_Mutation_p.R376S	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	376					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CAGGTCGGCCCGCCTGAACTC	0.562000													43	171					1.0442e-30	2.24214e-30	0.014410	1	0
DNAH11	8701	broad.mit.edu	37	7	21655913	21655913	+	Silent	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:21655913G>A	ENST00000328843.6	+	22	4129	c.4098G>A	c.(4096-4098)gcG>gcA	p.A1366A	DNAH11_ENST00000409508.3_Intron			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1366	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTGCCAAGGCGAGTTCCATAA	0.408000									Kartagener syndrome				15	80					0	0	0.012319	0	0
GIF	2694	broad.mit.edu	37	11	59610572	59610572	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:59610572G>T	ENST00000541311.1	-	3	458	c.224C>A	c.(223-225)aCc>aAc	p.T75N	GIF_ENST00000257248.2_Missense_Mutation_p.T100N			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	100					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						GCAGGAGGAGGTGAGGGCCAT	0.527000													8	29					2.80697e-09	4.19847e-09	0.010729	1	0
MYLK3	91807	broad.mit.edu	37	16	46766215	46766215	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:46766215G>A	ENST00000394809.4	-	4	1482	c.1367C>T	c.(1366-1368)cCt>cTt	p.P456L	MYLK3_ENST00000536476.1_Missense_Mutation_p.P115L	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	456					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CTCAGGCTCAGGGTTTCCCGC	0.657000													5	9					0	0	0.001168	0	0
NHLRC2	374354	broad.mit.edu	37	10	115664629	115664629	+	Silent	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:115664629A>G	ENST00000369301.3	+	10	1970	c.1758A>G	c.(1756-1758)gaA>gaG	p.E586E		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	586					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		TCCTAGTAGAAAAACAGAAGA	0.413000													23	97					0	0	0.003954	0	0
FUNDC2	65991	broad.mit.edu	37	X	154282908	154282908	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:154282908G>T	ENST00000369498.3	+	5	785	c.531G>T	c.(529-531)ggG>ggT	p.G177G	FUNDC2_ENST00000484175.1_3'UTR	NM_023934.3	NP_076423.2	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	177						mitochondrion				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	13	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TAGTAACTGGGGGATTTTTCG	0.408000													30	140					4.46736e-08	6.15582e-08	0.005524	1	0
TRPM8	79054	broad.mit.edu	37	2	234851353	234851353	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:234851353C>A	ENST00000324695.4	+	6	700	c.660C>A	c.(658-660)gtC>gtA	p.V220V	TRPM8_ENST00000433712.2_5'UTR|TRPM8_ENST00000409625.1_Silent_p.V143V|TRPM8_ENST00000355722.4_Silent_p.V170V	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	220						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GGGGCATGGTCTCCAACCGGG	0.552000													19	75					2.89027e-11	4.77167e-11	0.014323	1	0
PTPRT	11122	broad.mit.edu	37	20	41419861	41419861	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:41419861T>A	ENST00000373198.3	-	3	695	c.460A>T	c.(460-462)Agc>Tgc	p.S154C	PTPRT_ENST00000373201.1_Missense_Mutation_p.S154C|PTPRT_ENST00000373184.1_Missense_Mutation_p.S154C|PTPRT_ENST00000373193.3_Missense_Mutation_p.S154C|PTPRT_ENST00000373190.1_Missense_Mutation_p.S154C|PTPRT_ENST00000373187.1_Missense_Mutation_p.S154C|PTPRT_ENST00000356100.2_Missense_Mutation_p.S154C	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	154	MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CAGAAAGTGCTGATGGCGAGC	0.483000													40	145					0	0	0.014410	0	0
XPR1	9213	broad.mit.edu	37	1	180775252	180775252	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:180775252G>T	ENST00000367590.4	+	5	700	c.502G>T	c.(502-504)Gaa>Taa	p.E168*	XPR1_ENST00000367589.3_Nonsense_Mutation_p.E168*	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	168	SPX.					integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						CAAGATCCTGGAAACATCTCG	0.398000													13	85					6.94344e-10	1.08491e-09	0.006122	1	0
PCDHB12	56124	broad.mit.edu	37	5	140588872	140588872	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:140588872C>A	ENST00000239450.2	+	1	582	c.393C>A	c.(391-393)ccC>ccA	p.P131P	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		131	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATCACTCTCCCGTCTTCTTGG	0.413000													19	79					8.24728e-16	1.52559e-15	0.004656	1	0
TRPC3	7222	broad.mit.edu	37	4	122853870	122853870	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:122853870G>T	ENST00000264811.5	-	1	742	c.324C>A	c.(322-324)ctC>ctA	p.L108L	TRPC3_ENST00000513531.1_Silent_p.L108L|TRPC3_ENST00000379645.3_Silent_p.L181L	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	96					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TGCTGATGGCGAGCAGCAGGG	0.647000													7	30					7.03913e-09	1.03083e-08	0.013537	1	0
ADAM2	2515	broad.mit.edu	37	8	39624684	39624684	+	Nonsense_Mutation	SNP	G	G	T	rs150053966	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:39624684G>T	ENST00000265708.4	-	13	1402	c.1299C>A	c.(1297-1299)tgC>tgA	p.C433*	ADAM2_ENST00000521880.1_Nonsense_Mutation_p.C433*|ADAM2_ENST00000379853.2_Nonsense_Mutation_p.C307*|ADAM2_ENST00000347580.4_Nonsense_Mutation_p.C414*	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	433	Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		GACAGTTTTCGCAGCATGGTC	0.348000													19	86					2.94398e-08	4.17164e-08	0.007413	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803625	185803625	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:185803625C>T	ENST00000302277.6	+	4	4096	c.3502C>T	c.(3502-3504)Cag>Tag	p.Q1168*		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1168						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGCTCCTCCTCAGATGCCAAT	0.517000													27	142					0	0	0.008361	0	0
CHD6	84181	broad.mit.edu	37	20	40049592	40049592	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:40049592C>A	ENST00000373233.3	-	31	5860	c.5683G>T	c.(5683-5685)Gag>Tag	p.E1895*		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1895					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GTAGTGGGCTCCGTGAGATGC	0.502000													19	67					1.55795e-14	2.78205e-14	0.012319	1	0
SCN10A	6336	broad.mit.edu	37	3	38743392	38743392	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:38743392T>A	ENST00000449082.2	-	26	4594	c.4595A>T	c.(4594-4596)cAg>cTg	p.Q1532L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1532					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GAAGTAGTACTGCCTCAAAGC	0.483000													25	80					0	0	0.003755	0	0
PASD1	139135	broad.mit.edu	37	X	150840929	150840929	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:150840929C>A	ENST00000370357.4	+	14	1957	c.1712C>A	c.(1711-1713)cCa>cAa	p.P571Q		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	571						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					caagagcagccactgaagcaT	0.522000													19	62					5.35356e-11	8.75582e-11	0.016522	1	0
ABCA12	26154	broad.mit.edu	37	2	215848372	215848372	+	Splice_Site	SNP	T	T	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:215848372T>G	ENST00000272895.7	-	29	4600	c.4382_splice	c.e29+1	p.R1461_splice	ABCA12_ENST00000389661.4_Splice_Site_p.R1143_splice	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1461	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTAACTTGCCTTTTTACTTCC	0.413000													18	80					0	0	0.010504	0	0
DNAAF3	352909	broad.mit.edu	37	19	55677335	55677335	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:55677335G>T	ENST00000527223.2	-	3	324	c.323C>A	c.(322-324)aCa>aAa	p.T108K	DNAAF3_ENST00000524407.2_Missense_Mutation_p.T40K|DNAAF3_ENST00000391720.4_Missense_Mutation_p.T87K|CTD-2587H24.5_ENST00000591665.1_RNA	NM_001256714.1	NP_001243643.1	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	40																	GCTGTGCACTGTATCGGCCTG	0.632000											OREG0025679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	27					0.000602214	0.00065054	0.014758	1	0
CDH10	1008	broad.mit.edu	37	5	24537780	24537780	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:24537780G>T	ENST00000264463.4	-	3	742	c.235C>A	c.(235-237)Cat>Aat	p.H79N		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	79	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.H79N(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGGTCTGAATGTAGCTAGGGG	0.363000										HNSCC(23;0.051)			4	38					3.59834e-05	4.14282e-05	0.001168	1	0
DOCK9	23348	broad.mit.edu	37	13	99535354	99535354	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:99535354C>A	ENST00000376460.1	-	23	2581	c.2501G>T	c.(2500-2502)tGt>tTt	p.C834F	DOCK9_ENST00000339416.2_Missense_Mutation_p.C835F|DOCK9_ENST00000442173.1_Missense_Mutation_p.C834F|DOCK9_ENST00000448493.2_Missense_Mutation_p.C846F	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	835	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGTTTTCTGACAGTACTGGAA	0.378000													11	37					5.16669e-11	8.48986e-11	0.010729	1	0
TRBV6-9	28598	broad.mit.edu	37	7	142104545	142104545	+	RNA	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:142104545G>T	ENST00000390379.1	-	0	8																											ACAGGAGCCCGATGCTCATGG	0.602000													23	100					2.20474e-14	3.91704e-14	0.003755	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995391	57995391	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:57995391G>T	ENST00000316770.2	-	1	999	c.957C>A	c.(955-957)aaC>aaA	p.N319K		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	319					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				TAAGCCTTCAGTTGGCGTCAG	0.488000													68	294					2.93416e-43	6.45884e-43	0.014410	1	0
OGDHL	55753	broad.mit.edu	37	10	50952126	50952126	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:50952126G>T	ENST00000374103.4	-	14	1860	c.1775C>A	c.(1774-1776)cCa>cAa	p.P592Q	OGDHL_ENST00000419399.1_Missense_Mutation_p.P535Q|OGDHL_ENST00000432695.1_Missense_Mutation_p.P383Q	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	592					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CCCCGTGGCTGGGCATGTCAT	0.592000													3	14					5.18039e-06	6.38429e-06	0.003080	1	0
NBPF22P	285622	broad.mit.edu	37	5	85578382	85578382	+	RNA	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:85578382G>C	ENST00000590707.1	+	0	105					NR_003719.2																						CAGGCATACCGGTCCCTGTTT	0.473000													3	7					0	0	0.009096	0	0
ELP4	26610	broad.mit.edu	37	11	31648715	31648715	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:31648715G>C	ENST00000395934.2	+	6	719	c.712G>C	c.(712-714)Gaa>Caa	p.E238Q	ELP4_ENST00000350638.5_Missense_Mutation_p.E238Q|ELP4_ENST00000379163.5_Missense_Mutation_p.E239Q			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	238					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					CATTTATGAGGAAGGATTTGA	0.368000													16	54					0	0	0.006122	0	0
OR2T6	254879	broad.mit.edu	37	1	248551426	248551426	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:248551426C>A	ENST00000355728.2	+	1	517	c.517C>A	c.(517-519)Caa>Aaa	p.Q173K		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCCTCTCACCAAATCAATCA	0.527000													8	31					0.000442599	0.000481086	0.006214	1	0
DSG3	1830	broad.mit.edu	37	18	29055744	29055744	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:29055744C>A	ENST00000257189.4	+	16	2604	c.2521C>A	c.(2521-2523)Ctg>Atg	p.L841M		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	841					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGCTGATGACCTGGATGACAG	0.468000													16	62					5.26018e-13	9.20531e-13	0.012319	1	0
CEP120	153241	broad.mit.edu	37	5	122685675	122685675	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:122685675G>T	ENST00000306467.5	-	19	2993	c.2689C>A	c.(2689-2691)Cga>Aga	p.R897R	CEP120_ENST00000328236.5_Silent_p.R897R|CEP120_ENST00000306481.6_Silent_p.R871R			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	897						centrosome		p.R897*(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						AATTCTTGTCGCTCGGTTTTT	0.368000													13	47					3.41278e-10	5.42943e-10	0.004990	1	0
MYH7	4625	broad.mit.edu	37	14	23900816	23900816	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:23900816C>T	ENST00000355349.3	-	8	872	c.710G>A	c.(709-711)cGg>cAg	p.R237Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	237	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GTTGTCGTTCCGGACGGTCTT	0.597000													6	250					0	0	0.001984	0	0
CCDC36	339834	broad.mit.edu	37	3	49294549	49294549	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:49294549C>A	ENST00000438782.1	+	8	1855	c.1619C>A	c.(1618-1620)tCt>tAt	p.S540Y	CCDC36_ENST00000296449.5_Missense_Mutation_p.S540Y|CCDC36_ENST00000452691.2_Missense_Mutation_p.S540Y			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	540										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AGCAGGTGCTCTTCCCAAGAC	0.542000													27	70					1.26454e-06	1.62121e-06	0.005443	1	0
OR6K2	81448	broad.mit.edu	37	1	158670181	158670181	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:158670181C>T	ENST00000359610.2	-	1	305	c.262G>A	c.(262-264)Gag>Aag	p.E88K		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					ATGCTCCTCTCACTAAGCAGG	0.463000													122	224					0	0	0.014410	0	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971050	31971050	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:31971050G>T	ENST00000334897.3	-	1	169	c.144C>A	c.(142-144)ttC>ttA	p.F48L		NM_181604.1	NP_853635.1	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	48						intermediate filament		p.F48L(1)		endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11						AGCCACAGAAGAAGCGGGAGC	0.552000													13	46					6.33239e-15	1.15434e-14	0.010504	1	0
GRIN3A	116443	broad.mit.edu	37	9	104432892	104432892	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:104432892C>A	ENST00000361820.3	-	3	2402	c.1802G>T	c.(1801-1803)gGg>gTg	p.G601V		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	601					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTTTCCATCCCCTACAATATA	0.463000													13	26					0.000308642	0.000336525	0.003163	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110535061	110535061	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:110535061C>A	ENST00000378402.5	+	75	12376	c.12272C>A	c.(12271-12273)gCa>gAa	p.A4091E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	4091					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAGCCGGTGGCAGCACAGCCA	0.483000										HNSCC(38;0.096)			11	18					7.03913e-09	1.03083e-08	0.013537	1	0
CHD6	84181	broad.mit.edu	37	20	40049593	40049593	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:40049593C>A	ENST00000373233.3	-	31	5859	c.5682G>T	c.(5680-5682)acG>acT	p.T1894T		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1894					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TAGTGGGCTCCGTGAGATGCA	0.498000													19	67					1.55795e-14	2.78205e-14	0.012319	1	0
EHBP1	23301	broad.mit.edu	37	2	63217959	63217959	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:63217959C>T	ENST00000263991.5	+	18	3412	c.2930C>T	c.(2929-2931)tCa>tTa	p.S977L	EHBP1_ENST00000354487.3_Missense_Mutation_p.S942L|EHBP1_ENST00000405289.1_Missense_Mutation_p.S942L|EHBP1_ENST00000405015.3_Missense_Mutation_p.S906L|EHBP1_ENST00000496857.1_3'UTR|EHBP1_ENST00000431489.1_Missense_Mutation_p.S906L	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	977						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			ACTGAGAGCTCAGAGCAGGAC	0.423000													15	61					0	0	0.004990	0	0
OR10Q1	219960	broad.mit.edu	37	11	57996246	57996246	+	Silent	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:57996246G>C	ENST00000316770.2	-	1	144	c.102C>G	c.(100-102)ctC>ctG	p.L34L		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				GGAGGAGGAAGAGAAGGAAGA	0.527000													35	193					0	0	0.014410	0	0
SPEF2	79925	broad.mit.edu	37	5	35641547	35641547	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:35641547A>T	ENST00000440995.2	+	3	176	c.176A>T	c.(175-177)aAa>aTa	p.K59I	SPEF2_ENST00000356031.3_Missense_Mutation_p.K59I|SPEF2_ENST00000282469.6_Missense_Mutation_p.K59I|SPEF2_ENST00000509059.1_Missense_Mutation_p.K59I			Q9C093	SPEF2_HUMAN	sperm flagellar 2	59	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCAAGTGCCAAACTTAATAAT	0.363000													9	49					0	0	0.013537	0	0
CASP4	837	broad.mit.edu	37	11	104825561	104825561	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:104825561C>A	ENST00000444739.2	-	2	1085	c.175G>T	c.(175-177)Gac>Tac	p.D59Y	CASP4_ENST00000531333.1_5'UTR|CASP4_ENST00000393150.3_Missense_Mutation_p.D3Y	NM_001225.3	NP_001216.1	P49662	CASP4_HUMAN	caspase 4, apoptosis-related cysteine peptidase	59	CARD.				apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		TGCATAGAGTCTGCCATGACC	0.373000													27	125					7.11191e-15	1.28308e-14	0.013726	1	0
ZBTB7C	201501	broad.mit.edu	37	18	45566337	45566337	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:45566337C>A	ENST00000588982.1	-	3	1643	c.1142G>T	c.(1141-1143)cGg>cTg	p.R381L	ZBTB7C_ENST00000535628.2_Missense_Mutation_p.R381L|ZBTB7C_ENST00000586438.1_Missense_Mutation_p.R381L|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.R381L|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.R381L			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	381						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CCTCATGTGCCGCGGCAGCTT	0.652000													4	26					3.07112e-06	3.7982e-06	0.010729	1	0
SEPT3	55964	broad.mit.edu	37	22	42388740	42388740	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr22:42388740C>T	ENST00000396425.3	+	8	969	c.838C>T	c.(838-840)Cga>Tga	p.R280*	SEPT3_ENST00000291236.11_Nonsense_Mutation_p.R216*|SEPT3_ENST00000328414.8_3'UTR|SEPT3_ENST00000396426.3_Nonsense_Mutation_p.R280*|SEPT3_ENST00000406029.1_Nonsense_Mutation_p.R216*	NM_019106.5	NP_061979.3	Q9UH03	SEPT3_HUMAN	septin 3	280					cell cycle|cytokinesis	cell junction|septin complex	GTP binding			breast(1)|kidney(3)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17						GGTCCTCGGCCGAAAAACTCC	0.488000													6	31					0	0	0.001168	0	0
COL11A1	1301	broad.mit.edu	37	1	103471678	103471678	+	Splice_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:103471678C>A	ENST00000358392.2	-	17	2091		c.e17-1		COL11A1_ENST00000461720.1_Splice_Site|COL11A1_ENST00000512756.1_Splice_Site|COL11A1_ENST00000370096.3_Splice_Site|COL11A1_ENST00000353414.4_Splice_Site	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGACGACCCTAATAATGCC	0.368000													20	46					7.01153e-11	1.13089e-10	0.007291	1	0
ADNP2	22850	broad.mit.edu	37	18	77895267	77895267	+	Silent	SNP	C	C	T	rs141229292		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:77895267C>T	ENST00000262198.4	+	4	2426	c.1971C>T	c.(1969-1971)ccC>ccT	p.P657P		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	657					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GTTCCATGCCCGGCATGCCCT	0.632000													7	21					0	0	0.006214	0	0
SYN3	8224	broad.mit.edu	37	22	32914260	32914260	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr22:32914260C>G	ENST00000358763.2	-	13	1622	c.1380G>C	c.(1378-1380)agG>agC	p.R460S	SYN3_ENST00000467095.1_5'UTR|SYN3_ENST00000332840.5_Missense_Mutation_p.R460S	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	460	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						GTGGGGAGAGCCTCTGTTGGG	0.592000													11	33					0	0	0.008871	0	0
RGAG1	57529	broad.mit.edu	37	X	109694088	109694088	+	Silent	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:109694088A>T	ENST00000465301.2	+	3	489	c.243A>T	c.(241-243)gtA>gtT	p.V81V	RGAG1_ENST00000540313.1_Silent_p.V81V	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	81										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TAATGGGAGTACCAAACTCTG	0.542000											OREG0019909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	103	459					0	0	0.014410	0	0
ERCC5	2073	broad.mit.edu	37	13	103527867	103527867	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:103527867G>T	ENST00000355739.4	+	15	4598	c.3175G>T	c.(3175-3177)Ggc>Tgc	p.G1059C	ERCC5_ENST00000375954.1_Missense_Mutation_p.G292C|ERCC5_ENST00000472247.1_3'UTR	NM_000123.3	NP_000114.2			excision repair cross-complementing rodent repair deficiency, complementation group 5											breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	51	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CCAGAAGAGAGGCATAACAAA	0.418000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				36	217					9.73076e-26	2.03938e-25	0.006999	1	0
LYZL1	84569	broad.mit.edu	37	10	29581544	29581544	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:29581544G>T	ENST00000375500.3	+	3	431	c.374G>T	c.(373-375)aGc>aTc	p.S125I		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	79					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				CAGATCAACAGCTTCGCGTGG	0.562000													10	39					0.00316338	0.00334496	0.003163	1	0
PTPRH	5794	broad.mit.edu	37	19	55718234	55718234	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:55718234G>C	ENST00000376350.3	-	3	197	c.175C>G	c.(175-177)Cag>Gag	p.Q59E	PTPRH_ENST00000263434.5_Missense_Mutation_p.Q59E|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	59	Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TTGGAGTTCTGTGAGTCTAGG	0.592000													13	46					0	0	0.004990	0	0
MICAL2	9645	broad.mit.edu	37	11	12225804	12225804	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:12225804T>C	ENST00000256194.4	+	4	560	c.272T>C	c.(271-273)aTa>aCa	p.I91T	MICAL2_ENST00000527546.1_Missense_Mutation_p.I91T|MICAL2_ENST00000527195.1_3'UTR|MICAL2_ENST00000342902.5_Missense_Mutation_p.I91T|MICAL2_ENST00000537344.1_Missense_Mutation_p.I91T|MICAL2_ENST00000379612.3_Missense_Mutation_p.I91T	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	91						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CAGTGTCTCATAGTTGGGGGA	0.557000													7	37					0	0	0.010729	0	0
IRS4	8471	broad.mit.edu	37	X	107976364	107976364	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:107976364C>G	ENST00000372129.2	-	1	3287	c.3211G>C	c.(3211-3213)Gta>Cta	p.V1071L		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	1071						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						AGCCTAGCTACAGGTGGTGGT	0.512000													12	67					0	0	0.007413	0	0
OSBPL8	114882	broad.mit.edu	37	12	76780440	76780440	+	Splice_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:76780440C>A	ENST00000261183.3	-	13	1832	c.1352_splice	c.e13-1	p.E451_splice	OSBPL8_ENST00000393250.4_Splice_Site_p.E409_splice|OSBPL8_ENST00000393249.2_Splice_Site_p.E409_splice	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	451					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						CAAGAGCTGCCCTAAAACACA	0.299000													11	42					3.45872e-05	4.02176e-05	0.004007	1	0
DCAF8L1	139425	broad.mit.edu	37	X	27998107	27998107	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:27998107G>T	ENST00000441525.1	-	1	1459	c.1345C>A	c.(1345-1347)Cgg>Agg	p.R449R		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	449										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						AACTCACTCCGGGGGCCATAG	0.468000													11	41					3.27435e-08	4.52974e-08	0.002450	1	0
NRXN1	9378	broad.mit.edu	37	2	50692594	50692594	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:50692594G>T	ENST00000404971.1	-	18	4809	c.3470C>A	c.(3469-3471)cCa>cAa	p.P1157Q	NRXN1_ENST00000402717.3_Missense_Mutation_p.P1109Q|NRXN1_ENST00000401710.1_Missense_Mutation_p.P135Q|NRXN1_ENST00000406859.3_Missense_Mutation_p.P1117Q|NRXN1_ENST00000405472.3_Missense_Mutation_p.P1109Q|NRXN1_ENST00000406316.2_Missense_Mutation_p.P1117Q|NRXN1_ENST00000401669.2_Missense_Mutation_p.P1117Q|NRXN1_ENST00000331040.5_5'UTR	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1117	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATTGCAGAGTGGTCCACTGAA	0.448000													9	64					3.27435e-08	4.52974e-08	0.002450	1	0
LINC01410	103352539	broad.mit.edu	37	9	66466234	66466234	+	RNA	SNP	G	G	A	rs139595665	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:66466234G>A	ENST00000424345.1	+	0	867																											agagagagccggacagactcc	0.458000													3	19					0	0	0.014758	0	0
PIGO	84720	broad.mit.edu	37	9	35091498	35091498	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:35091498C>A	ENST00000378617.3	-	7	2780	c.2386G>T	c.(2386-2388)Gtg>Ttg	p.V796L	PIGO_ENST00000341666.3_Missense_Mutation_p.V796L|PIGO_ENST00000361778.2_Intron|PIGO_ENST00000298004.5_Intron	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	796					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGAGGGACCACATAATCCAAG	0.582000													12	38					1.15088e-07	1.54332e-07	0.004007	1	0
SMARCA4	6597	broad.mit.edu	37	19	11144075	11144075	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:11144075A>T	ENST00000358026.2	+	26	3940	c.3656A>T	c.(3655-3657)aAg>aTg	p.K1219M	SMARCA4_ENST00000541122.2_Missense_Mutation_p.K1219M|SMARCA4_ENST00000450717.3_Missense_Mutation_p.K1219M|SMARCA4_ENST00000444061.3_Missense_Mutation_p.K1219M|SMARCA4_ENST00000429416.3_Missense_Mutation_p.K1219M|SMARCA4_ENST00000413806.3_Missense_Mutation_p.K1219M|SMARCA4_ENST00000589677.1_Missense_Mutation_p.K1219M|SMARCA4_ENST00000590574.1_Missense_Mutation_p.K1219M|SMARCA4_ENST00000344626.4_Missense_Mutation_p.K1219M	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1219	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCTGCAGCCAAGTACAAGCTC	0.637000			"""F, N, Mis"""		NSCLC								9	22					0	0	0.013537	0	0
DLG2	1740	broad.mit.edu	37	11	83585468	83585468	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:83585468C>A	ENST00000398309.2	-	11	1715	c.1245G>T	c.(1243-1245)ctG>ctT	p.L415L	DLG2_ENST00000330014.6_Silent_p.L354L|DLG2_ENST00000532653.1_Silent_p.L415L|DLG2_ENST00000524982.1_Silent_p.L415L|DLG2_ENST00000531015.1_Silent_p.L382L|DLG2_ENST00000418306.2_Silent_p.L312L|DLG2_ENST00000398301.2_Silent_p.L454L|DLG2_ENST00000280241.8_Silent_p.L454L|DLG2_ENST00000376104.2_Silent_p.L520L|DLG2_ENST00000543673.1_Silent_p.L520L|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000537455.1_Silent_p.L169L	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	415						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CTTACCCTTCCAGGGAGACGG	0.453000													5	34					0.000157383	0.000173767	0.003080	1	0
VSX1	30813	broad.mit.edu	37	20	25059479	25059479	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:25059479C>T	ENST00000376709.4	-	3	876	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	VSX1_ENST00000429762.3_Missense_Mutation_p.E205K|VSX1_ENST00000424574.1_Missense_Mutation_p.E205K|VSX1_ENST00000451258.1_Missense_Mutation_p.E205K|VSX1_ENST00000376707.3_Missense_Mutation_p.E205K|VSX1_ENST00000444511.2_Missense_Mutation_p.E205K	NM_014588.5	NP_055403.2	Q9NZR4	VSX1_HUMAN	visual system homeobox 1	205					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E205K(1)		central_nervous_system(1)|large_intestine(3)|lung(2)	6						ATCCGGTCTTCGGGGAGCTCA	0.542000													23	100					0	0	0.009535	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19202827	19202827	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:19202827C>A	ENST00000375341.3	-	12	1577	c.1320G>T	c.(1318-1320)caG>caT	p.Q440H	ALDH4A1_ENST00000538309.1_Missense_Mutation_p.Q380H|ALDH4A1_ENST00000290597.5_Missense_Mutation_p.Q440H|ALDH4A1_ENST00000538839.1_Intron|RP13-279N23.2_ENST00000494072.3_3'UTR	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	440					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TGATGGGCTCCTGAGGGTCCT	0.617000													29	32					6.90743e-12	1.15675e-11	0.003755	1	0
PDZRN4	29951	broad.mit.edu	37	12	41967025	41967025	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:41967025A>T	ENST00000298919.7	+	10	2052	c.1664A>T	c.(1663-1665)aAg>aTg	p.K555M	PDZRN4_ENST00000539469.2_Missense_Mutation_p.K557M|PDZRN4_ENST00000402685.2_Missense_Mutation_p.K815M			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	815							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGGCAGCAAGCTTCCTGAT	0.507000													102	418					0	0	0.014410	0	0
CDKL3	51265	broad.mit.edu	37	5	133642367	133642367	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:133642367C>A	ENST00000521118.1	-	10	1505	c.1391G>T	c.(1390-1392)cGc>cTc	p.R464L	CDKL3_ENST00000265334.4_Missense_Mutation_p.R464L|CDKL3_ENST00000518409.1_Intron|CDKL3_ENST00000523054.1_Missense_Mutation_p.R275L|CDKL3_ENST00000435240.2_Missense_Mutation_p.R169L|CDKL3_ENST00000536186.1_Missense_Mutation_p.R169L			Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3	464						cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(3)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAAGAAGTGCGTCTCTTTTT	0.333000													5	21					0.00116845	0.00124682	0.001168	1	0
FAM47B	170062	broad.mit.edu	37	X	34961433	34961433	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:34961433C>A	ENST00000329357.5	+	1	521	c.485C>A	c.(484-486)gCt>gAt	p.A162D		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	162										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CTGGAGGACGCTTGGGCTCGT	0.587000													10	52					0.00010058	0.00011247	0.013537	1	0
DRD5	1816	broad.mit.edu	37	4	9783868	9783868	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:9783868G>C	ENST00000304374.2	+	1	611	c.215G>C	c.(214-216)cGc>cCc	p.R72P		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	72					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CGCCACCTGCGCGCCAACATG	0.642000													3	17					0	0	0.001168	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184605296	184605296	+	Splice_Site	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:184605296A>T	ENST00000334690.6	+	13	1489		c.e13-1		TRAPPC11_ENST00000512476.1_Splice_Site|TRAPPC11_ENST00000357207.4_Splice_Site	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11																		TTTTTCTAATAGGAGATAATC	0.323000													3	28					0	0	0.004672	0	0
FAM209B	388799	broad.mit.edu	37	20	55111465	55111465	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:55111465A>G	ENST00000371325.1	+	2	583	c.487A>G	c.(487-489)Aaa>Gaa	p.K163E		NM_001013646.2	NP_001013668.2	Q5JX69	CT107_HUMAN	family with sequence similarity 209, member B	163						integral to membrane											CACAATCTGTAAAATATGGGG	0.418000													5	42					0	0	0.003080	0	0
TRIO	7204	broad.mit.edu	37	5	14482690	14482690	+	Splice_Site	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:14482690G>T	ENST00000344204.4	+	46	6489		c.e46-1		TRIO_ENST00000537187.1_Splice_Site	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TCTTGTTTTAGGGGAAAATCG	0.448000													9	18					4.68919e-08	6.3613e-08	0.008291	1	0
MAGEB1	4112	broad.mit.edu	37	X	30269224	30269224	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:30269224T>A	ENST00000378981.3	+	4	935	c.614T>A	c.(613-615)cTg>cAg	p.L205Q	MAGEB1_ENST00000397548.2_Missense_Mutation_p.L205Q|MAGEB1_ENST00000397550.1_Missense_Mutation_p.L205Q	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	205	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						ATGCCTCTCCTGGGTGTGATC	0.488000													12	31					0	0	0.004990	0	0
TAF6	6878	broad.mit.edu	37	7	99717343	99717343	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:99717343G>T	ENST00000437822.2	-	1	121	c.27C>A	c.(25-27)atC>atA	p.I9I	RP11-506M12.1_ENST00000494221.1_RNA|CNPY4_ENST00000262932.3_5'UTR	NM_001190415.1	NP_001177344.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	0					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCAAGCGGTGATTGTTTGTA	0.552000													8	33					1.5842e-08	2.26314e-08	0.001855	1	0
C10orf137	26098	broad.mit.edu	37	10	127431758	127431758	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:127431758C>G	ENST00000337623.3	+	17	2506	c.2401C>G	c.(2401-2403)Caa>Gaa	p.Q801E	C10orf137_ENST00000356792.4_Missense_Mutation_p.Q835E	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ACACTATGTACAAGTATTAAA	0.358000													7	23					0	0	0.004482	0	0
REN	5972	broad.mit.edu	37	1	204124180	204124180	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:204124180C>A	ENST00000367195.2	-	9	1219	c.1176G>T	c.(1174-1176)cgG>cgT	p.R392R	REN_ENST00000272190.8_Silent_p.R395R			P00797	RENI_HUMAN	renin	395					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGTTGTTACGCCGATCAAACT	0.637000													6	21					2.17888e-05	2.55053e-05	0.006214	1	0
DHRS9	10170	broad.mit.edu	37	2	169938310	169938310	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:169938310C>A	ENST00000327239.4	+	5	1723	c.219C>A	c.(217-219)acC>acA	p.T73T	DHRS9_ENST00000428522.1_Silent_p.T73T|DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000357546.2_Silent_p.T73T|DHRS9_ENST00000602501.1_Silent_p.T73T|DHRS9_ENST00000412271.1_Silent_p.T73T|DHRS9_ENST00000436483.2_Silent_p.T73T|DHRS9_ENST00000432060.2_Silent_p.T133T	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	73					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						AGGCAGAAACCTCAGAGAGAC	0.473000													18	80					6.44725e-10	1.01646e-09	0.014323	1	0
USP15	9958	broad.mit.edu	37	12	62784975	62784975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:62784975C>T	ENST00000280377.5	+	16	2057	c.1999C>T	c.(1999-2001)Cag>Tag	p.Q667*	USP15_ENST00000353364.3_Nonsense_Mutation_p.Q638*|USP15_ENST00000393654.3_Nonsense_Mutation_p.Q642*	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	667					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TGAATCCAGCCAGGATCAAGA	0.333000													14	63					0	0	0.008871	0	0
C2orf57	165100	broad.mit.edu	37	2	232458213	232458213	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:232458213C>A	ENST00000313965.2	+	1	639	c.551C>A	c.(550-552)cCt>cAt	p.P184H		NM_152614.2	NP_689827.2	Q53QW1	CB057_HUMAN	chromosome 2 open reading frame 57	184										endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	19		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		CAGCATGGCCCTCAGGCTGCC	0.597000													6	18					1.58986e-06	2.00885e-06	0.008291	1	0
OGDHL	55753	broad.mit.edu	37	10	50952128	50952128	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:50952128G>T	ENST00000374103.4	-	14	1858	c.1773C>A	c.(1771-1773)tgC>tgA	p.C591*	OGDHL_ENST00000419399.1_Nonsense_Mutation_p.C534*|OGDHL_ENST00000432695.1_Nonsense_Mutation_p.C382*	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	591					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CCGTGGCTGGGCATGTCATGC	0.597000													3	13					0.00116845	0.00124682	0.001168	1	0
YWHAG	7532	broad.mit.edu	37	7	75959117	75959117	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:75959117C>A	ENST00000307630.3	-	2	743	c.521G>T	c.(520-522)gGc>gTc	p.G174V		NM_012479.3	NP_036611.2	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	174					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8						AAGAGCCAGGCCTAATCGGAT	0.597000													22	92					6.07407e-21	1.2218e-20	0.007291	1	0
MSRA	4482	broad.mit.edu	37	8	10102618	10102618	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:10102618G>T	ENST00000528246.1	+	4	641	c.18G>T	c.(16-18)atG>atT	p.M6I	MSRA_ENST00000521209.2_Missense_Mutation_p.M6I|MSRA_ENST00000382490.5_Missense_Mutation_p.M29I|MSRA_ENST00000441698.2_Intron|MSRA_ENST00000518255.1_Missense_Mutation_p.M72I|MSRA_ENST00000317173.4_Missense_Mutation_p.M72I	NM_001199729.1	NP_001186658.1	Q9UJ68	MSRA_HUMAN	methionine sulfoxide reductase A	72					methionine metabolic process|protein modification process|response to oxidative stress	mitochondrion|nucleus	peptide-methionine-(S)-S-oxide reductase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(4)	8		Myeloproliferative disorder(644;0.178)			L-Methionine(DB00134)	TTTAAGGAATGGGATGTTTCT	0.343000													26	96					3.73148e-12	6.33989e-12	0.007291	1	0
MYH15	22989	broad.mit.edu	37	3	108172929	108172929	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:108172929T>C	ENST00000273353.3	-	22	2439	c.2383A>G	c.(2383-2385)Aaa>Gaa	p.K795E		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	795	IQ.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTGAAGACTTTAGATAGTCTC	0.433000													16	68					0	0	0.004990	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751895	140751895	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:140751895C>A	ENST00000576222.1	+	1	2065	c.1934C>A	c.(1933-1935)aCt>aAt	p.T645N	PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTGGTCACTGTGCGTGAT	0.647000													3	9					1.06961e-07	1.43986e-07	0.003080	1	0
CCDC34	91057	broad.mit.edu	37	11	27371802	27371802	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:27371802C>A	ENST00000317945.6	-	3	722	c.683G>T	c.(682-684)aGg>aTg	p.R228M	CCDC34_ENST00000529615.1_Intron|CCDC34_ENST00000328697.6_Intron	NM_080654.2	NP_542385.1	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34	0										endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|urinary_tract(1)	9						TTTTTAAAACCTAGGTAATGA	0.353000													7	31					4.68919e-08	6.3613e-08	0.008291	1	0
IFIT1B	439996	broad.mit.edu	37	10	91144373	91144373	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:91144373C>A	ENST00000371809.3	+	2	1383	c.1303C>A	c.(1303-1305)Cgg>Agg	p.R435R	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	435							binding			endometrium(2)|large_intestine(3)|lung(8)	13						CCAGAATGTACGGGTTGTGGA	0.408000													51	206					3.4597e-24	7.12291e-24	0.014410	1	0
ZNF776	284309	broad.mit.edu	37	19	58265121	58265121	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:58265121A>G	ENST00000317178.5	+	3	886	c.623A>G	c.(622-624)tAc>tGc	p.Y208C		NM_173632.3	NP_775903.3			zinc finger protein 776											cervix(1)|endometrium(2)|kidney(13)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		AAAACTCATTACATCTGTGGA	0.438000													20	76					0	0	0.005443	0	0
CEACAM4	1089	broad.mit.edu	37	19	42126009	42126009	+	Missense_Mutation	SNP	C	C	T	rs1126455		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:42126009C>T	ENST00000600925.1	-	6	807	c.697G>A	c.(697-699)Ggc>Agc	p.G233S	CEACAM4_ENST00000221954.2_Intron			O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	0						integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						CCCCTGGAGCCTGCGGGACCA	0.602000													4	15					0	0	0.001984	0	0
APOB	338	broad.mit.edu	37	2	21233632	21233632	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:21233632G>T	ENST00000233242.1	-	26	6235	c.6108C>A	c.(6106-6108)atC>atA	p.I2036I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2036					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAGCATCAATGATATTGATGG	0.398000													25	128					1.16021e-09	1.79678e-09	0.007291	1	0
RHBG	57127	broad.mit.edu	37	1	156347250	156347250	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:156347250G>A	ENST00000400992.2	+	3	507	c.139G>A	c.(139-141)Ggt>Agt	p.G47S	RHBG_ENST00000451864.2_Missense_Mutation_p.G47S|RHBG_ENST00000537040.1_Intron|RHBG_ENST00000368246.2_Missense_Mutation_p.G116S|RHBG_ENST00000255013.3_Missense_Mutation_p.G47S|RHBG_ENST00000368249.1_Missense_Mutation_p.G116S			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	116					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CTCCTTCCACGGTGGCCACAT	0.662000													16	51					0	0	0.004656	0	0
PRDM14	63978	broad.mit.edu	37	8	70980553	70980553	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:70980553G>C	ENST00000276594.2	-	4	1025	c.824C>G	c.(823-825)gCc>gGc	p.A275G		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	275	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GACTCCTTTGGCGATAAAACT	0.473000													5	18					0	0	0.001984	0	0
NRK	203447	broad.mit.edu	37	X	105179199	105179199	+	Silent	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:105179199T>A	ENST00000428173.2	+	21	3843	c.3540T>A	c.(3538-3540)ccT>ccA	p.P1180P	NRK_ENST00000243300.9_Silent_p.P1179P			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1179							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						AGGAATCACCTAAGCAACCCT	0.403000										HNSCC(51;0.14)			5	166					0	0	0.003080	0	0
HECTD2	143279	broad.mit.edu	37	10	93258885	93258885	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:93258885T>C	ENST00000446394.1	+	19	2040	c.1940T>C	c.(1939-1941)gTg>gCg	p.V647A	HECTD2_ENST00000298068.5_Missense_Mutation_p.V643A|HECTD2_ENST00000371667.1_Missense_Mutation_p.V293A|HECTD2_ENST00000536715.1_Missense_Mutation_p.V232A			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	643	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						TTTCATAGTGTGTGTGCTTCA	0.294000													6	56					0	0	0.010729	0	0
ZNF507	22847	broad.mit.edu	37	19	32845048	32845048	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:32845048A>G	ENST00000311921.3	+	2	1504	c.1312A>G	c.(1312-1314)Atg>Gtg	p.M438V	ZNF507_ENST00000587084.1_3'UTR|ZNF507_ENST00000544431.1_Missense_Mutation_p.M438V|ZNF507_ENST00000355898.5_Missense_Mutation_p.M438V	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					GCGCGAAGGAATGGATGATGT	0.443000													14	75					0	0	0.003163	0	0
AMPH	273	broad.mit.edu	37	7	38471802	38471802	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:38471802C>A	ENST00000356264.2	-	13	1360	c.1145G>T	c.(1144-1146)tGg>tTg	p.W382L	AMPH_ENST00000325590.5_Missense_Mutation_p.W382L|AMPH_ENST00000428293.2_Missense_Mutation_p.W382L	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	382					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						CCATAGGTCCCAGGGCAATGT	0.323000													24	78					6.38683e-12	1.07471e-11	0.008361	1	0
ACCS	84680	broad.mit.edu	37	11	44097139	44097139	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:44097139G>A	ENST00000263776.8	+	6	987	c.553G>A	c.(553-555)Ggg>Agg	p.G185R	ACCS_ENST00000432284.2_3'UTR|ACCS_ENST00000533208.1_3'UTR	NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	185							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						GTGTGAGGCCGGGGGTAAGTG	0.582000													21	36					0	0	0.012319	0	0
DNAAF1	123872	broad.mit.edu	37	16	84203521	84203521	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:84203521G>T	ENST00000378553.5	+	8	1211	c.1087G>T	c.(1087-1089)Gag>Tag	p.E363*	DNAAF1_ENST00000563818.1_3'UTR|DNAAF1_ENST00000334315.5_Nonsense_Mutation_p.E363*	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	363					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						GGAAGGCAAGGAGGAGCCTCC	0.532000													4	9					0.000673444	0.000725247	0.008291	1	0
ASXL3	80816	broad.mit.edu	37	18	31324235	31324235	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:31324235G>T	ENST00000269197.5	+	12	4423	c.4423G>T	c.(4423-4425)Gtt>Ttt	p.V1475F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TAAAGTCATCGTTGACCACAG	0.537000											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	37					2.52088e-20	4.98478e-20	0.016522	1	0
LRRIQ4	344657	broad.mit.edu	37	3	169540089	169540089	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:169540089A>T	ENST00000340806.6	+	1	380	c.380A>T	c.(379-381)cAg>cTg	p.Q127L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	127										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						CGGCTCTACCAGACCGACCTG	0.572000													22	76					0	0	0.003954	0	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394381	39394381	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:39394381C>A	ENST00000254072.6	+	1	85	c.78C>A	c.(76-78)acC>acA	p.T26T		NM_031963.2	NP_114169.2	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9-8	26	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				lung(8)|ovary(1)|prostate(1)	10		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CTGTGACCACCTGCAGCAGCA	0.627000													21	25					1.22384e-17	2.34067e-17	0.013726	1	0
METTL25	84190	broad.mit.edu	37	12	82824741	82824741	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:82824741G>T	ENST00000248306.3	+	6	1418	c.1349G>T	c.(1348-1350)cGt>cTt	p.R450L	METTL25_ENST00000547357.1_3'UTR	NM_032230.2	NP_115606.2			methyltransferase like 25																		TGCTGTGGTCGTAATGCCAGA	0.378000													22	117					1.74807e-11	2.89964e-11	0.010818	1	0
BMS1P20	96610	broad.mit.edu	37	22	22661721	22661721	+	RNA	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr22:22661721G>T	ENST00000426066.1	+	0	500					NR_027293.1																						TTTTAGCTTTGTGCTTTTCCT	0.378000													3	27					8.12818e-05	9.20668e-05	0.001984	1	0
FLRT2	23768	broad.mit.edu	37	14	86089394	86089394	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:86089394C>A	ENST00000330753.4	+	2	2303	c.1536C>A	c.(1534-1536)gcC>gcA	p.A512A	FLRT2_ENST00000554746.1_Silent_p.A512A	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	512					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTTCAGAGGCCACCACCCATG	0.562000													17	59					1.42536e-11	2.37559e-11	0.004656	1	0
PTPRC	5788	broad.mit.edu	37	1	198677294	198677294	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:198677294C>A	ENST00000367376.2	+	10	1102	c.931C>A	c.(931-933)Caa>Aaa	p.Q311K	PTPRC_ENST00000594404.1_Missense_Mutation_p.Q150K|PTPRC_ENST00000352140.3_Missense_Mutation_p.Q263K|PTPRC_ENST00000442510.2_Missense_Mutation_p.Q313K|PTPRC_ENST00000348564.6_Missense_Mutation_p.Q152K	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	311					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TGATTGTACACAAGTTGAAAA	0.303000													9	54					1.5842e-08	2.26314e-08	0.001855	1	0
WDR27	253769	broad.mit.edu	37	6	170070699	170070699	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:170070699C>A	ENST00000333572.6	-	4	941	c.422G>T	c.(421-423)tGt>tTt	p.C141F	WDR27_ENST00000423258.1_Intron|WDR27_ENST00000448612.1_Missense_Mutation_p.C141F|WDR27_ENST00000420344.2_Missense_Mutation_p.C141F			A2RRH5	WDR27_HUMAN	WD repeat domain 27	141										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GTTTCCAGCACACACGGCAAC	0.498000													13	61					0.00244969	0.00259816	0.002450	1	0
MT-ND1	4535	broad.mit.edu	37	MT	3670	3670	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrM:3670G>A	ENST00000361390.2	+	1	364	c.364G>A	c.(364-366)Gca>Aca	p.122_122insT						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						GATCAGGGTGAGCATCAAACT	0.502000													143	1273					0	0	0.014410	0	0
NES	10763	broad.mit.edu	37	1	156640943	156640943	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:156640943G>T	ENST00000368223.3	-	4	3169	c.3037C>A	c.(3037-3039)Cac>Aac	p.H1013N		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1013	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCTCTGGGTGCCCCTCGCCT	0.622000													95	108					6.84326e-50	1.53535e-49	0.014410	1	0
SPON1	10418	broad.mit.edu	37	11	14157044	14157044	+	RNA	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:14157044C>T	ENST00000310358.7	+	0	1290							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GGAGGATATGCCAGCGAAGGC	0.483000													25	71					0	0	0.006320	0	0
NOL11	25926	broad.mit.edu	37	17	65717512	65717512	+	Translation_Start_Site	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:65717512A>T	ENST00000535137.1	+	0	334				NOL11_ENST00000581966.1_3'UTR|NOL11_ENST00000253247.4_Missense_Mutation_p.R111W			Q9H8H0	NOL11_HUMAN	nucleolar protein 11							nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGAAGTATATAGGATACTTTC	0.368000													14	51					0	0	0.008871	0	0
CEP112	201134	broad.mit.edu	37	17	63746794	63746794	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:63746794C>A	ENST00000392769.2	-	22	2661	c.2443G>T	c.(2443-2445)Gcc>Tcc	p.A815S	CEP112_ENST00000535342.2_Missense_Mutation_p.A815S|CEP112_ENST00000537949.1_Missense_Mutation_p.A773S|CEP112_ENST00000541355.1_Intron|CEP112_ENST00000580482.1_5'UTR|CEP112_ENST00000317442.8_Missense_Mutation_p.A71S	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	815						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						GAAGATTTGGCAAGCTTCTGA	0.393000													13	51					1.33834e-09	2.05446e-09	0.007413	1	0
ARR3	407	broad.mit.edu	37	X	69496325	69496325	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:69496325C>A	ENST00000374495.3	+	7	486	c.388C>A	c.(388-390)Cct>Act	p.P130T	ARR3_ENST00000307959.8_Missense_Mutation_p.P130T			P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	130					signal transduction|visual perception	cytoplasm|soluble fraction				endometrium(3)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	16						GCAGCCAGGTCCTGAAGATGC	0.463000													5	30					8.12818e-05	9.20668e-05	0.001984	1	0
SLC18A2	6571	broad.mit.edu	37	10	119014861	119014861	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:119014861G>T	ENST00000298472.5	+	7	917	c.774G>T	c.(772-774)ctG>ctT	p.L258L	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	258					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TGGCCGCCCTGGTACTCTTGG	0.627000													12	52					3.27435e-08	4.52974e-08	0.002450	1	0
LRRTM3	347731	broad.mit.edu	37	10	68687247	68687247	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:68687247C>G	ENST00000361320.4	+	2	1151	c.573C>G	c.(571-573)aaC>aaG	p.N191K	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000373744.4_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	191						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGGGATATAACCGGATCCGAA	0.473000													22	95					0	0	0.003330	0	0
ADRB2	154	broad.mit.edu	37	5	148206398	148206398	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:148206398G>A	ENST00000305988.4	+	1	243	c.4G>A	c.(4-6)Ggg>Agg	p.G2R		NM_000024.5	NP_000015.1	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	2					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	GCGCGCCATGGGGCAACCCGG	0.726000													6	22					0	0	0.010729	0	0
OPN5	221391	broad.mit.edu	37	6	47775891	47775891	+	Splice_Site	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:47775891T>A	ENST00000489301.2	+	5	843	c.756_splice	c.e5-1	p.V253_splice	OPN5_ENST00000371211.2_Splice_Site_p.V253_splice|OPN5_ENST00000244799.4_3'UTR|OPN5_ENST00000393699.2_Splice_Site_p.V253_splice			Q6U736	OPN5_HUMAN	opsin 5	253					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						CCTCATCAGGTAGCGATGTTG	0.468000													29	134					0	0	0.012213	0	0
OR52J3	119679	broad.mit.edu	37	11	5068347	5068347	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:5068347G>A	ENST00000380370.1	+	1	592	c.592G>A	c.(592-594)Ggt>Agt	p.G198S		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G198S(1)		NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCGTATCAATGGTATCTATGG	0.448000													34	127					0	0	0.003755	0	0
MSR1	4481	broad.mit.edu	37	8	16032713	16032713	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:16032713A>T	ENST00000350896.3	-	3	397	c.200T>A	c.(199-201)cTc>cAc	p.L67H	MSR1_ENST00000536385.1_Intron|MSR1_ENST00000355282.2_Missense_Mutation_p.L67H|MSR1_ENST00000381998.4_Missense_Mutation_p.L67H|MSR1_ENST00000262101.5_Missense_Mutation_p.L67H|MSR1_ENST00000445506.2_Missense_Mutation_p.L85H	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	67					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TATTCCAATGAGAGGGATGAG	0.418000													20	61					0	0	0.005443	0	0
GABRA3	2556	broad.mit.edu	37	X	151358394	151358394	+	Silent	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:151358394G>C	ENST00000370314.4	-	9	1189	c.951C>G	c.(949-951)acC>acG	p.T317T	GABRA3_ENST00000370311.1_Silent_p.T317T|GABRA3_ENST00000535043.1_Silent_p.T317T|GABRA3_ENST00000497894.1_5'UTR	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	317					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGGTGGTCATGGTAAGCACAG	0.438000													17	82					0	0	0.010504	0	0
TACC2	10579	broad.mit.edu	37	10	123970361	123970361	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:123970361A>T	ENST00000369005.1	+	9	6761	c.6421A>T	c.(6421-6423)Acc>Tcc	p.T2141S	TACC2_ENST00000453444.2_Missense_Mutation_p.T2145S|TACC2_ENST00000368999.1_Missense_Mutation_p.T219S|TACC2_ENST00000260733.3_Missense_Mutation_p.T219S|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000360561.3_Missense_Mutation_p.T219S|TACC2_ENST00000334433.3_Missense_Mutation_p.T2141S|TACC2_ENST00000369004.3_Missense_Mutation_p.T219S|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000515603.1_Missense_Mutation_p.T2096S|TACC2_ENST00000513429.1_Missense_Mutation_p.T287S|TACC2_ENST00000515273.1_Missense_Mutation_p.T2145S|TACC2_ENST00000358010.1_Missense_Mutation_p.T287S	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2141						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GAAACAGACCACCAAGAAACC	0.522000													37	146					0	0	0.010771	0	0
MYBL1	4603	broad.mit.edu	37	8	67477047	67477047	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:67477047C>A	ENST00000522677.3	-	16	2554	c.2144G>T	c.(2143-2145)tGg>tTg	p.W715L	MYBL1_ENST00000524176.2_Missense_Mutation_p.W655L|MYBL1_ENST00000517885.1_Missense_Mutation_p.W373L	NM_001080416.2|NM_001144755.1	NP_001073885.1|NP_001138227.1	P10243	MYBA_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 1	715					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|skin(1)	25			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			CACTGTTTCCCATTCACAATT	0.313000													3	10					0.00909568	0.00947467	0.009096	1	0
OR6B3	150681	broad.mit.edu	37	2	240984737	240984737	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:240984737G>T	ENST00000319423.4	-	1	752	c.753C>A	c.(751-753)ttC>ttA	p.F251L		NM_173351.1	NP_775486.1	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B, member 3	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(10)|lung(4)|ovary(2)|prostate(1)	18		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		AGGCTGTATAGAAGACGGTGA	0.572000													22	41					7.33532e-06	8.8836e-06	0.003954	1	0
KCNJ3	3760	broad.mit.edu	37	2	155711558	155711558	+	Silent	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:155711558C>T	ENST00000295101.2	+	3	1716	c.1239C>T	c.(1237-1239)ccC>ccT	p.P413P	KCNJ3_ENST00000544049.1_3'UTR	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	413					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	AAGACTTTCCCAAAAAACTCT	0.388000													41	179					0	0	0.013114	0	0
POLG	5428	broad.mit.edu	37	15	89868839	89868839	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:89868839C>A	ENST00000268124.5	-	10	2124	c.1791G>T	c.(1789-1791)cgG>cgT	p.R597R	POLG_ENST00000442287.2_Silent_p.R597R	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	597					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TAGGTGTGACCCGCATCTGCA	0.637000								DNA polymerases (catalytic subunits)					4	19					3.59834e-05	4.14282e-05	0.001168	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													7	311					0	0	0.001984	0	0
LPHN3	23284	broad.mit.edu	37	4	62598867	62598867	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:62598867G>T	ENST00000512091.1	+	7	1537	c.790G>T	c.(790-792)Gac>Tac	p.D264Y	LPHN3_ENST00000506746.1_Missense_Mutation_p.D332Y|LPHN3_ENST00000514996.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000506700.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000514157.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000506720.1_Missense_Mutation_p.D332Y|LPHN3_ENST00000511324.1_Missense_Mutation_p.D332Y|LPHN3_ENST00000509896.1_Missense_Mutation_p.D332Y|LPHN3_ENST00000514591.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000508946.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000508693.1_Missense_Mutation_p.D332Y|LPHN3_ENST00000504896.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000545650.1_Missense_Mutation_p.D264Y|LPHN3_ENST00000507625.1_Missense_Mutation_p.D332Y|LPHN3_ENST00000507164.1_Missense_Mutation_p.D332Y			Q9HAR2	LPHN3_HUMAN	latrophilin 3	264	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.D264N(3)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ATCTGACATAGACCTGGCAGT	0.428000													4	23					8.12818e-05	9.20668e-05	0.001984	1	0
OR1K1	392392	broad.mit.edu	37	9	125562401	125562401	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:125562401C>A	ENST00000277309.2	+	0	32					NM_080859.1	NP_543135.1	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K, member 1						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(8)|lung(2)|ovary(1)|skin(4)|stomach(1)	17						ACCAGCCTGCCATGGAGGCTG	0.507000													9	37					1.5739e-10	2.5269e-10	0.004007	1	0
WDR53	348793	broad.mit.edu	37	3	196288135	196288135	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:196288135T>C	ENST00000332629.5	-	3	779	c.212A>G	c.(211-213)cAt>cGt	p.H71R	WDR53_ENST00000433160.1_Intron|WDR53_ENST00000429115.1_Intron	NM_182627.1	NP_872433.1	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	71										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	13	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GGTTTCTCCATGTGAGGCATA	0.438000													16	42					0	0	0.012319	0	0
PCDH19	57526	broad.mit.edu	37	X	99661647	99661647	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:99661647G>C	ENST00000373034.4	-	1	3624	c.1949C>G	c.(1948-1950)aCa>aGa	p.T650R	PCDH19_ENST00000420881.2_Missense_Mutation_p.T650R|PCDH19_ENST00000255531.7_Missense_Mutation_p.T650R	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	650	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						AGAGAGAGATGTCTTGCCGTG	0.522000													3	11					0	0	0.004672	0	0
UROC1	131669	broad.mit.edu	37	3	126222906	126222906	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:126222906C>G	ENST00000290868.2	-	9	887	c.834G>C	c.(832-834)gaG>gaC	p.E278D	UROC1_ENST00000383579.3_Missense_Mutation_p.E278D	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	278					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TGTGGCGTTTCTCAAGGGCTG	0.567000													7	24					0	0	0.001855	0	0
ITIH1	3697	broad.mit.edu	37	3	52814365	52814365	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:52814365C>A	ENST00000273283.2	+	6	678	c.654C>A	c.(652-654)gcC>gcA	p.A218A	ITIH1_ENST00000537050.1_5'UTR|ITIH1_ENST00000542827.1_Silent_p.A218A|ITIH1_ENST00000487686.1_3'UTR|ITIH1_ENST00000540715.1_Silent_p.A76A	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	218					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AACTGGCAGCCCAAACTATCA	0.532000													3	12					1.23904e-05	1.48008e-05	0.014758	1	0
SUCO	51430	broad.mit.edu	37	1	172571920	172571920	+	Silent	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:172571920C>T	ENST00000367723.3	+	21	3838	c.3714C>T	c.(3712-3714)ggC>ggT	p.G1238G	SUCO_ENST00000263688.3_Silent_p.G1086G|SUCO_ENST00000486569.1_3'UTR	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		AGTTAACTGGCAAAGAAGGTA	0.338000													109	230					0	0	0.014410	0	0
LAMB4	22798	broad.mit.edu	37	7	107746311	107746311	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:107746311C>A	ENST00000388781.3	-	8	904	c.821G>T	c.(820-822)tGt>tTt	p.C274F	LAMB4_ENST00000414450.2_Missense_Mutation_p.C274F|LAMB4_ENST00000388780.3_Missense_Mutation_p.C274F|LAMB4_ENST00000205386.4_Missense_Mutation_p.C274F	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	274	Laminin EGF-like 1.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CATAGGGCGACATTCGCTAGC	0.473000													23	50					1.06647e-15	1.95427e-15	0.003755	1	0
RYR2	6262	broad.mit.edu	37	1	237550672	237550672	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:237550672C>A	ENST00000366574.2	+	9	985	c.668C>A	c.(667-669)gCa>gAa	p.A223E	RYR2_ENST00000542537.1_Missense_Mutation_p.A207E|RYR2_ENST00000360064.6_Missense_Mutation_p.A221E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	223					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAAGTGAGGCAGCCCAAGGT	0.478000													36	51					2.2871e-25	4.76478e-25	0.007835	1	0
NMUR2	56923	broad.mit.edu	37	5	151775020	151775020	+	Splice_Site	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:151775020C>A	ENST00000255262.3	-	3	1102	c.937_splice	c.e3+1	p.G313_splice		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	313					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AAGGTTTTACCTGACACCACA	0.488000													23	106					1.50538e-07	2.01101e-07	0.006320	1	0
LRRC3B	116135	broad.mit.edu	37	3	26751695	26751695	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:26751695G>T	ENST00000396641.2	+	2	1124	c.532G>T	c.(532-534)Gat>Tat	p.D178Y	LRRC3B_ENST00000456208.2_Missense_Mutation_p.D178Y|LRRC3B_ENST00000417744.1_Missense_Mutation_p.D178Y	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	178	LRRCT.					integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						GTCCGTGTTGGATGAACATGC	0.502000													5	36					0.000157383	0.000173767	0.003080	1	0
NKX6-1	4825	broad.mit.edu	37	4	85416877	85416877	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:85416877G>T	ENST00000295886.4	-	2	1012	c.791C>A	c.(790-792)cCc>cAc	p.P264H	NKX6-1_ENST00000515820.2_5'UTR	NM_006168.2	NP_006159.2	P78426	NKX61_HUMAN	NK6 homeobox 1	264	Repressor domain (By similarity).				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	15		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		AGCCCTCTCGGGCCCCGCCAA	0.547000													10	42					3.27435e-08	4.52974e-08	0.002450	1	0
JADE3	9767	broad.mit.edu	37	X	46913593	46913593	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:46913593G>T	ENST00000218343.4	+	9	1304	c.1006G>T	c.(1006-1008)Gtc>Ttc	p.V336F	PHF16_ENST00000397189.1_Missense_Mutation_p.V336F	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		336					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						TGCCTTCCACGTCACCTGTGC	0.468000													9	31					5.50884e-06	6.69477e-06	0.013537	1	0
IL4I1	259307	broad.mit.edu	37	19	50392964	50392964	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:50392964G>C	ENST00000595948.1	-	10	2353	c.1733C>G	c.(1732-1734)tCt>tGt	p.S578C	IL4I1_ENST00000391826.2_Missense_Mutation_p.S556C|IL4I1_ENST00000341114.3_Missense_Mutation_p.S578C	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	556						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		GTTTTGGAGAGATAACTGGCC	0.582000													4	12					0	0	0.003080	0	0
HERC2	8924	broad.mit.edu	37	15	28443559	28443559	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:28443559C>A	ENST00000261609.7	-	50	8084	c.7976G>T	c.(7975-7977)gGa>gTa	p.G2659V		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2659					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGTCACAGATCCCCATTTGTA	0.403000													17	62					6.94344e-10	1.08491e-09	0.006122	1	0
DRD2	1813	broad.mit.edu	37	11	113295303	113295303	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:113295303C>A	ENST00000362072.3	-	2	415	c.71G>T	c.(70-72)gGg>gTg	p.G24V	DRD2_ENST00000542968.1_Missense_Mutation_p.G24V|DRD2_ENST00000544518.1_Missense_Mutation_p.G24V|DRD2_ENST00000538967.1_Missense_Mutation_p.G24V|DRD2_ENST00000355319.2_Missense_Mutation_p.G24V|DRD2_ENST00000346454.3_Missense_Mutation_p.G24V	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	24					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CCCGTCTGACCCGTTGAAGGG	0.592000													11	43					3.27435e-08	4.52974e-08	0.002450	1	0
GRIK3	2899	broad.mit.edu	37	1	37337884	37337884	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:37337884C>A	ENST00000373091.3	-	4	653	c.637G>T	c.(637-639)Gac>Tac	p.D213Y	GRIK3_ENST00000373093.4_Missense_Mutation_p.D213Y	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	213					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GGGCGCGAGTCGTCAGAGTCG	0.597000													19	37					9.65021e-13	1.65567e-12	0.010818	1	0
OR8B2	26595	broad.mit.edu	37	11	124252675	124252675	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:124252675A>T	ENST00000375013.2	-	1	583	c.565T>A	c.(565-567)Tgc>Agc	p.C189S		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GTGCTGGTGCAGGAAAGCTGG	0.478000													9	60					0	0	0.012319	0	0
POTEF	728378	broad.mit.edu	37	2	130877663	130877663	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:130877663C>A	ENST00000357462.5	-	1	519	c.426G>T	c.(424-426)aaG>aaT	p.K142N	POTEF_ENST00000361163.4_Missense_Mutation_p.K142N|POTEF_ENST00000360967.5_Missense_Mutation_p.K142N|POTEF_ENST00000409914.2_Missense_Mutation_p.K142N			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	142						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CTCTGTGGAGCTTGTCCAGAT	0.567000													5	29					0.00621372	0.00653093	0.006214	1	0
OCRL	4952	broad.mit.edu	37	X	128692649	128692649	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:128692649T>A	ENST00000371113.4	+	7	644	c.479T>A	c.(478-480)tTg>tAg	p.L160*	OCRL_ENST00000486673.1_3'UTR|OCRL_ENST00000357121.5_Nonsense_Mutation_p.L160*	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	160					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						TCTATGAATTTGGACAAGAAA	0.403000													21	80					0	0	0.004656	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926887	130926887	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:130926887G>T	ENST00000261655.4	-	8	1122	c.959C>A	c.(958-960)cCg>cAg	p.P320Q	RIMBP2_ENST00000536002.1_Missense_Mutation_p.P228Q|RIMBP2_ENST00000535703.1_Missense_Mutation_p.P228Q	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	320	Fibronectin type-III 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGGCACCGCCGGGGGCTCCCA	0.557000													8	31					2.80697e-09	4.19847e-09	0.010729	1	0
DGKK	139189	broad.mit.edu	37	X	50213372	50213372	+	RNA	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:50213372G>T	ENST00000376025.2	-	0	365							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					caggttctggggccggctctg	0.652000													4	13					7.48243e-07	9.62813e-07	0.006214	1	0
LHFP	10186	broad.mit.edu	37	13	40174995	40174995	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:40174995A>T	ENST00000379589.3	-	2	821	c.359T>A	c.(358-360)gTg>gAg	p.V120E		NM_005780.2	NP_005771.1	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner	120						integral to membrane	DNA binding		HMGA2/LHFP(2)	breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(6)|prostate(2)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		TCCTCCAGCCACTCTTCCCAC	0.507000			T	HMGA2	lipoma								13	49					0	0	0.007413	0	0
CKAP4	10970	broad.mit.edu	37	12	106633563	106633563	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:106633563G>A	ENST00000378026.4	-	2	1184	c.1048C>T	c.(1048-1050)Cag>Tag	p.Q350*		NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	350						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						GTGAGGGCCTGCAGGGCGAGC	0.642000													8	20					0	0	0.006214	0	0
BMS1	9790	broad.mit.edu	37	10	43292652	43292652	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:43292652G>T	ENST00000374518.4	+	10	2023	c.1960G>T	c.(1960-1962)Gaa>Taa	p.E654*		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	654					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTACAAGGAAGAAAATAATGA	0.383000													33	122					4.11147e-13	7.23124e-13	0.003755	1	0
KIR2DL1	3802	broad.mit.edu	37	19	55282330	55282330	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:55282330C>A	ENST00000336077.6	+	2	104	c.64C>A	c.(64-66)Cat>Aat	p.H22N	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.H22N|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000541392.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	22					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		GGCCTGGCCACATGAGGGTGA	0.552000													51	198					4.60343e-24	9.42222e-24	0.014410	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43777382	43777382	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:43777382C>A	ENST00000389420.3	-	31	4775	c.4776G>T	c.(4774-4776)gtG>gtT	p.V1592V		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1592	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGCTGTTACCACAATGTAAT	0.373000													12	76					1.49906e-05	1.77854e-05	0.002450	1	0
GRIA3	2892	broad.mit.edu	37	X	122616718	122616718	+	Silent	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:122616718G>T	ENST00000264357.5	+	15	2800	c.2508G>T	c.(2506-2508)ggG>ggT	p.G836G	GRIA3_ENST00000371251.1_Silent_p.G836G|GRIA3_ENST00000371256.5_Silent_p.G836G|GRIA3_ENST00000542149.1_3'UTR	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	836					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	GAGGTCTGGGGCTGGCCATGA	0.468000													23	89					1.85244e-09	2.83124e-09	0.003330	1	0
APMAP	57136	broad.mit.edu	37	20	24954301	24954301	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:24954301C>A	ENST00000217456.2	-	4	691	c.401G>T	c.(400-402)cGg>cTg	p.R134L	APMAP_ENST00000447138.1_Missense_Mutation_p.R134L	NM_020531.2	NP_065392.1			adipocyte plasma membrane associated protein																		CGAACCAAACCGGGCAATGGT	0.448000													9	39					7.03913e-09	1.03083e-08	0.013537	1	0
CLTCL1	8218	broad.mit.edu	37	22	19184160	19184160	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr22:19184160C>A	ENST00000263200.10	-	25	3953	c.3881G>T	c.(3880-3882)gGc>gTc	p.G1294V	CLTCL1_ENST00000353891.5_Missense_Mutation_p.G1294V|CLTCL1_ENST00000427926.1_Missense_Mutation_p.G1294V|CLTCL1_ENST00000442042.2_5'UTR	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1294	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					CTCAAAGTAGCCACGATCCTA	0.617000			T	?	ALCL								3	8					0.00116845	0.00124682	0.001168	1	0
UBAC2	337867	broad.mit.edu	37	13	99896102	99896102	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:99896102G>T	ENST00000403766.3	+	3	311	c.176G>T	c.(175-177)tGt>tTt	p.C59F	UBAC2_ENST00000376440.2_Intron	NM_001144072.1	NP_001137544.1	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2	59						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGGTTGATATGTGGAAGAATA	0.299000													8	18					0.00829132	0.00868851	0.008291	1	0
KDELC2	143888	broad.mit.edu	37	11	108348368	108348368	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:108348368T>C	ENST00000434945.2	-	6	1498	c.1196A>G	c.(1195-1197)cAc>cGc	p.H399R	KDELC2_ENST00000323468.5_Missense_Mutation_p.H455R|KDELC2_ENST00000532730.1_5'UTR			Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2	455						endoplasmic reticulum lumen				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		GTAAAGCCTGTGTGGCTGTAG	0.458000													21	92					0	0	0.007291	0	0
WASF1	8936	broad.mit.edu	37	6	110421772	110421772	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:110421772C>G	ENST00000392589.1	-	11	2469	c.1633G>C	c.(1633-1635)Gat>Cat	p.D545H	WASF1_ENST00000392588.1_Missense_Mutation_p.D545H|WASF1_ENST00000392586.1_Missense_Mutation_p.D545H|WASF1_ENST00000359451.2_Missense_Mutation_p.D545H|WASF1_ENST00000392587.2_Missense_Mutation_p.D545H	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	545					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		TCTTCCGAATCACTATATTCA	0.393000													8	29					0	0	0.008291	0	0
NLRP3	114548	broad.mit.edu	37	1	247608106	247608106	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:247608106C>A	ENST00000366497.2	+	8	3603	c.2823C>A	c.(2821-2823)tgC>tgA	p.C941*	NLRP3_ENST00000366496.2_Nonsense_Mutation_p.C941*|NLRP3_ENST00000391827.2_Nonsense_Mutation_p.C941*|NLRP3_ENST00000391828.3_Nonsense_Mutation_p.C998*|NLRP3_ENST00000336119.3_Nonsense_Mutation_p.C998*|NLRP3_ENST00000348069.2_Nonsense_Mutation_p.C884*	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	998					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGCAGAGCTGCCTCCTGCAGA	0.562000													14	36					1.33834e-09	2.05446e-09	0.007413	1	0
OR10A4	283297	broad.mit.edu	37	11	6898812	6898812	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:6898812T>C	ENST00000379829.2	+	1	957	c.934T>C	c.(934-936)Tct>Cct	p.S312P		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GACCCTGGGCTCTCAGAAACT	0.423000													6	130					0	0	0.003080	0	0
KSR1	8844	broad.mit.edu	37	17	25919562	25919562	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:25919562G>T	ENST00000398988.3	+	10	1243	c.798G>T	c.(796-798)agG>agT	p.R266S	KSR1_ENST00000319524.6_Missense_Mutation_p.R403S|KSR1_ENST00000268763.6_Missense_Mutation_p.R266S|KSR1_ENST00000509603.2_Missense_Mutation_p.R403S|KSR1_ENST00000581975.1_3'UTR	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	401					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GGCTTCGGAGGACAGAATCTG	0.527000													13	48					7.07596e-05	8.09342e-05	0.006122	1	0
EFTUD2	9343	broad.mit.edu	37	17	42931994	42931994	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:42931994C>T	ENST00000426333.2	-	22	2486	c.2189G>A	c.(2188-2190)cGt>cAt	p.R730H	EFTUD2_ENST00000592576.1_Missense_Mutation_p.R720H|EFTUD2_ENST00000402521.3_Missense_Mutation_p.R695H|EFTUD2_ENST00000591382.1_Missense_Mutation_p.R730H	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	730						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CCAGATGGAACGGGCAGCCAG	0.567000													10	60					0	0	0.004007	0	0
ADCK4	79934	broad.mit.edu	37	19	41209671	41209671	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:41209671C>A	ENST00000324464.3	-	8	967	c.666G>T	c.(664-666)caG>caT	p.Q222H	ADCK4_ENST00000450541.1_Missense_Mutation_p.Q181H|ADCK4_ENST00000243583.6_Missense_Mutation_p.Q181H	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	222	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CCTGGTGCACCTGCCCAATTG	0.672000													4	21					3.59834e-05	4.14282e-05	0.001168	1	0
TNRC18	84629	broad.mit.edu	37	7	5359984	5359984	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:5359984T>C	ENST00000399537.4	-	24	7058	c.6710A>G	c.(6709-6711)cAg>cGg	p.Q2237R	TNRC18_ENST00000430969.1_Missense_Mutation_p.Q2237R			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2237							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ACAGCGGTACTGCTGGCTCCA	0.582000													3	8					0	0	0.014758	0	0
MXRA5	25878	broad.mit.edu	37	X	3229248	3229248	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:3229248C>A	ENST00000217939.6	-	7	7150	c.6996G>T	c.(6994-6996)aaG>aaT	p.K2332N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2332	Ig-like C2-type 7.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCATCTCGTCCTTCCCGACCT	0.537000													11	55					6.81908e-15	1.23662e-14	0.002450	1	0
SLC8A3	6547	broad.mit.edu	37	14	70633732	70633732	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:70633732C>A	ENST00000381269.2	-	2	2161	c.1408G>T	c.(1408-1410)Gat>Tat	p.D470Y	SLC8A3_ENST00000528359.1_Missense_Mutation_p.D470Y|SLC8A3_ENST00000534137.1_Missense_Mutation_p.D470Y|SLC8A3_ENST00000357887.3_Missense_Mutation_p.D470Y|SLC8A3_ENST00000356921.2_Missense_Mutation_p.D470Y	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	470	Calx-beta 1.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding	p.D470fs*1(1)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATGTCGTCATCAATTATGCCC	0.517000													69	266					7.577e-32	1.63701e-31	0.014410	1	0
LRIT1	26103	broad.mit.edu	37	10	85992129	85992129	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:85992129C>A	ENST00000372105.3	-	4	1447	c.1426G>T	c.(1426-1428)Gtg>Ttg	p.V476L		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	476	Fibronectin type-III.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						CCAGGCTGCACAATCACCCGC	0.602000													3	17					0.00909568	0.00947467	0.009096	1	0
SEL1L2	80343	broad.mit.edu	37	20	13971163	13971163	+	Silent	SNP	C	C	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:13971163C>G	ENST00000284951.5	-	1	92	c.18G>C	c.(16-18)ctG>ctC	p.L6L	SEL1L2_ENST00000378072.5_Silent_p.L6L|SEL1L2_ENST00000486903.1_Intron			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	6						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TCTCTATTAACAGAGACAAGG	0.423000													4	41					0	0	0.014758	0	0
MMD2	221938	broad.mit.edu	37	7	4949570	4949570	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:4949570A>T	ENST00000404774.3	-	6	745	c.551T>A	c.(550-552)gTg>gAg	p.V184E	MMD2_ENST00000406755.1_Missense_Mutation_p.V160E|MMD2_ENST00000401401.3_Missense_Mutation_p.V160E	NM_001100600.1	NP_001094070.1	Q8IY49	PAQRA_HUMAN	monocyte to macrophage differentiation-associated 2	184						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		GAGAAGCTCCACAAGCTTGTA	0.572000													10	27					0	0	0.008291	0	0
MKRN3	7681	broad.mit.edu	37	15	23811062	23811062	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:23811062G>T	ENST00000314520.3	+	1	609	c.133G>T	c.(133-135)Gat>Tat	p.D45Y	MKRN3_ENST00000568252.1_Missense_Mutation_p.D45Y|MKRN3_ENST00000564592.1_Missense_Mutation_p.D45Y	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	45						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TGCTGCTCCAGATTCAGCCCT	0.701000													6	14					0.000157383	0.000173767	0.003080	1	0
MOCS3	27304	broad.mit.edu	37	20	49576281	49576281	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:49576281G>T	ENST00000244051.1	+	1	919	c.902G>T	c.(901-903)gGg>gTg	p.G301V		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	301					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						GCAGCTTGCGGGGAACGGCCC	0.592000													9	24					2.27111e-07	2.99958e-07	0.013537	1	0
RFX6	222546	broad.mit.edu	37	6	117240356	117240356	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:117240356C>A	ENST00000332958.2	+	11	1095	c.1079C>A	c.(1078-1080)tCc>tAc	p.S360Y		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	360					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						GTTGTTTCATCCTTGGAAAAC	0.348000													9	32					1.58986e-06	2.00885e-06	0.008291	1	0
EPHB6	2051	broad.mit.edu	37	7	142568573	142568573	+	Silent	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:142568573C>A	ENST00000392957.2	+	20	3769	c.2982C>A	c.(2980-2982)acC>acA	p.T994T	EPHB6_ENST00000476059.1_3'UTR|EPHB6_ENST00000442129.1_Silent_p.T994T|EPHB6_ENST00000411471.2_Silent_p.T717T	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	994	SAM.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TGGGCATCACCCTGGCTGGCC	0.622000													5	39					1.3612e-06	1.73876e-06	0.003163	1	0
FBXW7	55294	broad.mit.edu	37	4	153247364	153247364	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:153247364C>A	ENST00000281708.4	-	10	2667	c.1438G>T	c.(1438-1440)Gat>Tat	p.D480Y	FBXW7_ENST00000296555.5_Missense_Mutation_p.D362Y|FBXW7_ENST00000603548.1_Missense_Mutation_p.D480Y|FBXW7_ENST00000603841.1_Missense_Mutation_p.D480Y|FBXW7_ENST00000263981.5_Missense_Mutation_p.D400Y|FBXW7_ENST00000393956.3_Missense_Mutation_p.D304Y	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	480					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.D480Y(1)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGAGTGGCATCTCGAGAACCG	0.403000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								18	59					1.64113e-05	1.94053e-05	0.010504	1	0
TTN	7273	broad.mit.edu	37	2	179611535	179611535	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:179611535T>A	ENST00000360870.5	-	46	15814	c.15592A>T	c.(15592-15594)Aca>Tca	p.T5198S	TTN_ENST00000589042.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8717	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTAGTGTTGTGTTTTCATAT	0.378000													26	77					0	0	0.009535	0	0
MECP2	4204	broad.mit.edu	37	X	153297830	153297830	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:153297830C>A	ENST00000303391.6	-	3	454	c.205G>T	c.(205-207)Ggc>Tgc	p.G69C	MECP2_ENST00000453960.2_Missense_Mutation_p.G81C|MECP2_ENST00000407218.1_Missense_Mutation_p.G69C	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	69					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCGGAGCCTGACCCTTCT	0.627000													8	35					6.40141e-05	7.34588e-05	0.010729	1	0
PRKD2	25865	broad.mit.edu	37	19	47181713	47181713	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:47181713G>A	ENST00000433867.1	-	17	2755	c.2278C>T	c.(2278-2280)Cag>Tag	p.Q760*	PRKD2_ENST00000595515.1_Nonsense_Mutation_p.Q760*|PRKD2_ENST00000601806.1_Nonsense_Mutation_p.Q603*|PRKD2_ENST00000600194.1_Nonsense_Mutation_p.Q603*|PRKD2_ENST00000291281.4_Nonsense_Mutation_p.Q760*	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	760	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TTCTGGATCTGGTCATTGATG	0.627000													11	30					0	0	0.001855	0	0
RP11-466L17.1	0	broad.mit.edu	37	1	56082136	56082137	+	RNA	INS	-	-	TAA	rs71729945	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:56082136_56082137insTAA	ENST00000422374.1	+	0	240																											TCTCCACAACCTAATGTAGCTA	0.441													4	5	---	---	---	---					
RP11-776H12.1	0	broad.mit.edu	37	1	61037710	61037711	+	RNA	DEL	GT	GT	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:61037710_61037711delGT	ENST00000439156.2	-	0	1498																											TCAGTAAGTGgtgtgtgtgtgt	0.406													2	4	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68428402	68428403	+	RNA	INS	-	-	T	rs67382291	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:68428402_68428403insT	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000414904.1_RNA|GNG12-AS1_ENST00000413628.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			CTTGTGAATGCTTGCTCATGAA	0.480													8	1	---	---	---	---					
ZRANB2-AS2	100852410	broad.mit.edu	37	1	71572735	71572735	+	RNA	DEL	T	T	-	rs35136379		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:71572735delT	ENST00000455406.1	+	0	131				ZRANB2-AS2_ENST00000415780.1_RNA|ZRANB2-AS2_ENST00000596952.1_RNA	NR_046217.1																						ATGAGCTGACTTTTGGGAACA	0.368													3	3	---	---	---	---					
LINC01362	103283057	broad.mit.edu	37	1	83568767	83568768	+	RNA	INS	-	-	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:83568767_83568768insC	ENST00000452901.1	+	0	1539																											GCAATCCCCTGCCCCCCACCAG	0.446													2	4	---	---	---	---					
RP4-651E10.4	0	broad.mit.edu	37	1	87051351	87051352	+	RNA	DEL	TC	TC	-	rs5775916		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:87051351_87051352delTC	ENST00000456587.1	-	0	294																											CCATGAACCTtctctctctctc	0.475													6	3	---	---	---	---					
LOC149351	149351	broad.mit.edu	37	1	91272663	91272664	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:91272663_91272664insT	ENST00000435649.2	-	0	300																											tacttctaaggtttttacatgc	0.366													2	4	---	---	---	---					
RBM15	64783	broad.mit.edu	37	1	110882461	110882461	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:110882461delG	ENST00000369784.3	+	1	1334	c.434delG	c.(433-435)cgfs	p.R145fs	RBM15_ENST00000602849.1_Frame_Shift_Del_p.R145fs|RBM15_ENST00000487146.2_Frame_Shift_Del_p.R145fs	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	145	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGCAGCTCCCGGGGTGGAGGC	0.642			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	7	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142660732	142660732	+	RNA	DEL	A	A	-	rs112376355		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:142660732delA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							CCACACCCAGAAGCTGGCCAT	0.567													4	5	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143169463	143169463	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:143169463delC	ENST00000412204.2	-	0	2503				RP11-782C8.4_ENST00000424474.2_lincRNA|RP11-782C8.1_ENST00000438000.1_lincRNA																							CTGctgaccaccccccactaa	0.512													3	4	---	---	---	---					
LOC101927648	101927648	broad.mit.edu	37	1	143459861	143459861	+	RNA	DEL	T	T	-	rs143425331		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:143459861delT	ENST00000423249.1	-	0	59																											tctaaaattcttttttttttc	0.413													3	3	---	---	---	---					
SEC22B	9554	broad.mit.edu	37	1	145102367	145102368	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:145102367_145102368insT	ENST00000453618.1	+	0	402							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CCAGTTCACCATTTTTACATAT	0.342													2	4	---	---	---	---					
SPRR3	6707	broad.mit.edu	37	1	152975806	152975829	+	In_Frame_Del	DEL	CCAGGCTACACCAAGGTCCCTGAA	CCAGGCTACACCAAGGTCCCTGAA	-	rs1970328	byFrequency	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:152975806_152975829delCCAGGCTACACCAAGGTCCCTGAA	ENST00000331860.3	+	3	460_483	c.310_333delCCAGGCTACACCAAGGTCCCTGAA	c.(310-333)del	p.PGYTKVPE104del	SPRR3_ENST00000542696.1_In_Frame_Del_p.PGYTKVPE96del|SPRR3_ENST00000295367.4_In_Frame_Del_p.PGYTKVPE104del	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	104	14 X 8 AA approximate tandem repeats.		Missing.		keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity	p.Y106C(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTCCCTGAGCCAGGCTACACCAAGGTCCCTGAACCAGGCAGCA	0.567													21	236	---	---	---	---					
RP11-306I1.2	0	broad.mit.edu	37	1	165584257	165584257	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:165584257delT	ENST00000452618.1	+	0	315																											tcacttagaattaacagtctg	0.353													4	2	---	---	---	---					
RP1-45C12.1	0	broad.mit.edu	37	1	171210005	171210006	+	RNA	INS	-	-	A	rs74175124		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:171210005_171210006insA	ENST00000455124.1	-	0	415																											gcctgctaaccaaaaaaagccc	0.396													2	4	---	---	---	---					
RP1-45C12.1	0	broad.mit.edu	37	1	171215166	171215170	+	RNA	DEL	AAGTT	AAGTT	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:171215166_171215170delAAGTT	ENST00000455124.1	-	0	415																											GCCCAGGGACAAGTTAAGTCCCACC	0.371													6	0	---	---	---	---					
RP1-35C21.2	0	broad.mit.edu	37	1	177469057	177469058	+	RNA	INS	-	-	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:177469057_177469058insA	ENST00000438575.1	-	0	296																											ataataaaagcaaaaaaagaca	0.332													3	5	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187131782	187131785	+	RNA	DEL	TGTT	TGTT	-	rs112539106		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:187131782_187131785delTGTT	ENST00000458683.1	+	0	105																											tatatatatgtgtttgtgtgtgtg	0.402													6	0	---	---	---	---					
RP11-398M15.1	0	broad.mit.edu	37	1	189767956	189767988	+	RNA	DEL	AAAAGAAAAGAAAGAAAGGGAAGGAAGGAAGGG	AAAAGAAAAGAAAGAAAGGGAAGGAAGGAAGGG	-	rs149604754	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:189767956_189767988delAAAAGAAAAGAAAGAAAGGGAAGGAAGGAAGGG	ENST00000419614.1	+	0	364																											gaaggaaggaaaaagaaaagaaagaaagggaaggaaggaagggaggaaggaaa	0.425													3	6	---	---	---	---					
RP11-554K11.2	0	broad.mit.edu	37	1	213717454	213717456	+	RNA	DEL	AGA	AGA	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:213717454_213717456delAGA	ENST00000417161.1	+	0	275																											gaagagaaggagaagaagaaaga	0.414													7	3	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213962236	213962237	+	RNA	INS	-	-	CA	rs71785531	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:213962236_213962237insCA	ENST00000456240.1	+	0	143																											TTCCTCAGTTTCACACACACAC	0.416													2	4	---	---	---	---					
HLX-AS1	100873924	broad.mit.edu	37	1	221048578	221048579	+	RNA	DEL	GA	GA	-	rs72353756	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:221048578_221048579delGA	ENST00000552026.1	-	0	292																											gtgtgtgtgtgAGAGAGAGAGA	0.465													4	4	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222535508	222535508	+	RNA	DEL	A	A	-	rs35200504		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:222535508delA	ENST00000416510.1	-	0	167																											tgagagaaATAAAAACACTAA	0.348													5	2	---	---	---	---					
OBSCN	84033	broad.mit.edu	37	1	228506631	228506632	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:228506631_228506632insC	ENST00000570156.2	+	65	17123_17124	c.17049_17050insC	c.(17047-17052)ttccccfs	p.FP5683fs	OBSCN_ENST00000366707.4_Frame_Shift_Ins_p.FP2360fs|OBSCN_ENST00000284548.11_Frame_Shift_Ins_p.FP4726fs|OBSCN_ENST00000422127.1_Frame_Shift_Ins_p.FP4726fs|OBSCN_ENST00000366709.4_Frame_Shift_Ins_p.FP1845fs	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4726					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGCCCAGCTTGCCCCCCGAGGC	0.634													5	11	---	---	---	---					
LOC101927787	101927787	broad.mit.edu	37	1	234785251	234785253	+	RNA	DEL	GAT	GAT	-	rs5781794		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:234785251_234785253delGAT	ENST00000417805.1	+	0	217																											tagatagatagatgatagataga	0.389													2	4	---	---	---	---					
LOC101927787	101927787	broad.mit.edu	37	1	234798873	234798881	+	RNA	DEL	CTCACCTCG	CTCACCTCG	-	rs71873502		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:234798873_234798881delCTCACCTCG	ENST00000441360.1	+	0	98																											acctcattcactcacctcgctcacctcgc	0.555													4	2	---	---	---	---					
OR2T7	81458	broad.mit.edu	37	1	248605387	248605387	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr1:248605387delA	ENST00000460972.3	+	1	880	c.880delA	c.(880-882)agfs	p.K294fs						olfactory receptor, family 2, subfamily T, member 7																		GGCCCTACAGAAGGTTGTTGG	0.458													51	114	---	---	---	---					
AC105393.1	0	broad.mit.edu	37	2	410021	410023	+	RNA	DEL	CAC	CAC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:410021_410023delCAC	ENST00000431911.1	+	0	186																											tcgtcatccacaccaccatccac	0.527													5	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14525598	14525599	+	RNA	DEL	AT	AT	-	rs143256963	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:14525598_14525599delAT	ENST00000418420.1	-	0	116					NR_103814.1																						ATacatacacatacacacacac	0.391													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22629411	22629412	+	RNA	DEL	TG	TG	-	rs57188016		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:22629411_22629412delTG	ENST00000450551.1	-	0	70				AC096570.2_ENST00000419013.1_lincRNA																							tgtgtgtgtatgtgtgtgtgtg	0.441													5	4	---	---	---	---					
EPAS1	2034	broad.mit.edu	37	2	46574181	46574182	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:46574181_46574182delAC	ENST00000263734.3	+	2	706_707	c.196_197delAC	c.(196-198)afs	p.T66fs	EPAS1_ENST00000467888.1_3'UTR	NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	66	Helix-loop-helix motif.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CTTCCTGCGAACACACAAGCTC	0.589													19	94	---	---	---	---					
AC079807.4	0	broad.mit.edu	37	2	48257277	48257277	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:48257277delA	ENST00000447571.1	-	0	240																		p.0?(2)									ctttgactccaaaaatgtgtt	0.254													2	4	---	---	---	---					
LOC100507073	100507073	broad.mit.edu	37	2	66874194	66874195	+	RNA	INS	-	-	TCT	rs145977963		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:66874194_66874195insTCT	ENST00000433396.1	+	0	136																											cttcatttcaagacaattatgt	0.460													2	4	---	---	---	---					
AC023115.2	0	broad.mit.edu	37	2	67497865	67497865	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:67497865delA	ENST00000452716.1	+	0	461																											CTCAAATGAGAAAAAAAAAAT	0.269													2	4	---	---	---	---					
LINC00152	112597	broad.mit.edu	37	2	87754980	87754981	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:87754980_87754981insT	ENST00000409054.1	+	0	94_95					NR_015395.1																						AGGTGTGCGCCTTTTTTTTTTT	0.431													2	4	---	---	---	---					
IGKV2D-26	28884	broad.mit.edu	37	2	90025094	90025094	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:90025094delA	ENST00000390268.2	+	0	79																											TTTAGTGTATAAATACAAACA	0.328													2	4	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145679811	145679811	+	RNA	DEL	T	T	-	rs112622251		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:145679811delT	ENST00000445791.1	+	0	307					NR_033870.2																						aagtagtgcattttttttttt	0.353													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164709387	164709387	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:164709387delC	ENST00000429636.1	-	0	379																											gtgctcttttcccctttaagt	0.333													2	4	---	---	---	---					
AC013463.2	0	broad.mit.edu	37	2	165918094	165918095	+	RNA	INS	-	-	AA	rs59612423		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:165918094_165918095insAA	ENST00000431341.1	+	0	299																											cacacacacacacacacacaca	0.450													5	3	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182002224	182002224	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:182002224delG	ENST00000435411.1	+	0	144																											TTCATTTTGAGGGCAGAAGTA	0.413													2	4	---	---	---	---					
MSL3P1	151507	broad.mit.edu	37	2	234776109	234776110	+	RNA	INS	-	-	TTTC	rs143809926	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr2:234776109_234776110insTTTC	ENST00000438684.1	-	0	118					NR_024322.1																						TAATCTACGAAtttctttcttt	0.485													4	3	---	---	---	---					
AC026188.1	0	broad.mit.edu	37	3	3449679	3449679	+	RNA	DEL	A	A	-	rs112006750		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:3449679delA	ENST00000455703.1	-	0	59																											tcagcaaggcatttgtggcca	0.547													3	4	---	---	---	---					
BHLHE40-AS1	100507582	broad.mit.edu	37	3	4941403	4941403	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:4941403delT	ENST00000420832.1	-	0	464				BHLHE40-AS1_ENST00000438479.1_RNA|BHLHE40-AS1_ENST00000434530.1_RNA|BHLHE40-AS1_ENST00000441386.2_RNA																							atgacactcctatgaggtggc	0.478													2	4	---	---	---	---					
AC027119.1	0	broad.mit.edu	37	3	6009232	6009239	+	RNA	DEL	TTCCTTCC	TTCCTTCC	-	rs10576670		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:6009232_6009239delTTCCTTCC	ENST00000425894.1	+	0	322																											ccttctttctttccttccttccttcctt	0.486													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18554684	18554688	+	RNA	DEL	AAAAT	AAAAT	-	rs7614190	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:18554684_18554688delAAAAT	ENST00000593741.1	+	0	234				AC144521.1_ENST00000599762.1_RNA|AC144521.1_ENST00000596850.1_RNA|AC144521.1_ENST00000598498.1_RNA|AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000596277.1_RNA|AC144521.1_ENST00000595250.1_RNA|AC144521.1_ENST00000595865.1_RNA|AC144521.1_ENST00000598390.1_RNA|AC144521.1_ENST00000593444.1_RNA|AC144521.1_ENST00000598740.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000456253.2_RNA|AC144521.1_ENST00000598688.1_RNA|AC144521.1_ENST00000414198.1_RNA																							agaaaagagaaaaataaaagaaaag	0.366													5	6	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18914093	18914093	+	RNA	DEL	A	A	-	rs71634860		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:18914093delA	ENST00000425799.2	+	0	463																											gttttcagttaaaaaaaaaat	0.368													2	4	---	---	---	---					
LINC00693	645206	broad.mit.edu	37	3	28773157	28773158	+	RNA	INS	-	-	AAAC	rs56827991	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:28773157_28773158insAAAC	ENST00000432518.2	+	0	809				LINC00693_ENST00000443912.1_RNA|LINC00693_ENST00000445077.1_RNA	NR_038840.1																						aacaataattaaaacaaacaaa	0.297													3	5	---	---	---	---					
PSMD6-AS2	100507062	broad.mit.edu	37	3	63993252	63993252	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:63993252delG	ENST00000472046.1	+	0	2047					NR_038286.1																						TTGCCATTGTGGAGGCACAGG	0.443													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82206110	82206111	+	RNA	DEL	TC	TC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:82206110_82206111delTC	ENST00000470263.1	+	0	244																											cctccttttgtctctctctctc	0.391													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82294610	82294611	+	RNA	INS	-	-	T	rs151258434	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:82294610_82294611insT	ENST00000470263.1	+	0	472																											aaacacaggtatttttttcact	0.401													4	2	---	---	---	---					
LINC00636	285205	broad.mit.edu	37	3	107642942	107642942	+	RNA	DEL	T	T	-	rs60960742		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:107642942delT	ENST00000494231.1	+	0	229					NR_015394.1																						tctaactttctgtgattctCC	0.403													4	6	---	---	---	---					
RP11-457K10.1	0	broad.mit.edu	37	3	109437830	109437830	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:109437830delA	ENST00000485384.1	+	0	29																											acttacagtcatggcggaagt	0.458													2	4	---	---	---	---					
NPHP3-AS1	348808	broad.mit.edu	37	3	132544870	132544871	+	RNA	DEL	TG	TG	-	rs72165867		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:132544870_132544871delTG	ENST00000504440.1	+	0	1690					NR_002811.1																						tgtatatatatgtgtgtgtgtg	0.391													3	5	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153520128	153520129	+	RNA	INS	-	-	GTC	rs139852255		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:153520128_153520129insGTC	ENST00000488210.1	-	0	477																											ttacactgttgtgttggtggga	0.426													3	6	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153551152	153551153	+	RNA	DEL	AC	AC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:153551152_153551153delAC	ENST00000488210.1	-	0	477																											acacacgcaaacacacacacac	0.426													2	4	---	---	---	---					
LINC00886	730091	broad.mit.edu	37	3	156495869	156495870	+	RNA	DEL	CA	CA	-	rs56753046		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:156495869_156495870delCA	ENST00000472943.1	-	0	148					NR_038387.1																						cacacacacgcacacacacaca	0.401													2	4	---	---	---	---					
RP11-644C3.1	0	broad.mit.edu	37	3	176513031	176513031	+	RNA	DEL	G	G	-	rs35168732		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr3:176513031delG	ENST00000428516.1	-	0	198																											TGCAAAAAAAGTCGTGAGCTT	0.373													5	2	---	---	---	---					
LINC01182	101929071	broad.mit.edu	37	4	13753519	13753530	+	RNA	DEL	CCATCCATCCAC	CCATCCATCCAC	-	rs78872955		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:13753519_13753530delCCATCCATCCAC	ENST00000510907.1	+	0	281																											atccatccatccatccatccacccatccatcc	0.509													3	4	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15154167	15154167	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:15154167delT	ENST00000502344.1	-	0	154				RP11-665G4.1_ENST00000513384.1_RNA																							GTCCCTATGATTCTGTTGTAC	0.468													7	1	---	---	---	---					
RP11-17E2.2	0	broad.mit.edu	37	4	22258093	22258094	+	RNA	DEL	AG	AG	-	rs60384222		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:22258093_22258094delAG	ENST00000510705.3	+	0	859																											atcagcaaacagagatagtttg	0.356													2	4	---	---	---	---					
GBA3	57733	broad.mit.edu	37	4	22820551	22820551	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:22820551delG	ENST00000508264.1	+	0	373				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000511446.1_RNA|GBA3_ENST00000508166.1_RNA			Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CTGTAGGCAAGATGGCTGAGA	0.443													15	33	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46125833	46125833	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:46125833delC	ENST00000295452.4	-	1	265	c.98delG	c.(97-99)gafs	p.G33fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	33					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCACCAGTTTCCCAAATGCAG	0.408													17	93	---	---	---	---					
PCAT4	118425	broad.mit.edu	37	4	80775419	80775420	+	RNA	INS	-	-	AG	rs112716466	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:80775419_80775420insAG	ENST00000504263.1	+	0	133					NR_026555.1																						cacacacacacacacacTAAAT	0.421													3	3	---	---	---	---					
RP11-767N15.1	0	broad.mit.edu	37	4	84592391	84592392	+	RNA	INS	-	-	T	rs34772432		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:84592391_84592392insT	ENST00000510169.1	-	0	494																											aattattagccttttttttttt	0.485													2	4	---	---	---	---					
LINC01365	101927007	broad.mit.edu	37	4	120721214	120721215	+	RNA	INS	-	-	A	rs72524700	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:120721214_120721215insA	ENST00000512219.1	-	0	496																											TAAAGTCAGGCACCCTGGTCAT	0.351													4	2	---	---	---	---					
RP11-138I17.1	0	broad.mit.edu	37	4	138097802	138097803	+	RNA	DEL	AC	AC	-	rs72374220		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:138097802_138097803delAC	ENST00000505736.1	-	0	63																											agctttcaaaacacacacacac	0.361													4	5	---	---	---	---					
RP11-371F15.3	0	broad.mit.edu	37	4	139829418	139829425	+	RNA	DEL	GAAGGAAG	GAAGGAAG	-	rs61653964		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:139829418_139829425delGAAGGAAG	ENST00000507038.1	-	0	158				RP11-371F15.3_ENST00000511951.1_RNA																							aagaaagaaagaaggaaggaaggaagga	0.356													3	5	---	---	---	---					
RP11-526A4.1	0	broad.mit.edu	37	4	150623452	150623453	+	RNA	INS	-	-	CA	rs72189763		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:150623452_150623453insCA	ENST00000511993.1	-	0	763				RP11-707F2.1_ENST00000505781.1_lincRNA																							CTCCCTCACTTcacacacacac	0.411													4	3	---	---	---	---					
LOC90768	90768	broad.mit.edu	37	4	182896070	182896070	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:182896070delT	ENST00000509012.1	-	0	378																											cgataggtaatttttcaaacc	0.413													2	4	---	---	---	---					
F11-AS1	285441	broad.mit.edu	37	4	187282061	187282061	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:187282061delA	ENST00000505103.1	-	0	153					NR_033900.1																						CTTTTGCATTAAAAAAAAAAT	0.338													3	5	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190825160	190825160	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr4:190825160delT	ENST00000511785.1	-	0	231																											GCTGATTTCATTTTTCCATCA	0.353													4	5	---	---	---	---					
LOC729506	729506	broad.mit.edu	37	5	8392375	8392376	+	RNA	INS	-	-	A	rs35990792		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:8392375_8392376insA	ENST00000501071.1	-	0	168				RP11-480D4.2_ENST00000512406.1_lincRNA	NR_039984.1																						GTTTTAAACTTAAAAAAAAAAA	0.351													5	5	---	---	---	---					
LOC646241	646241	broad.mit.edu	37	5	17903234	17903235	+	RNA	INS	-	-	TTACATCAGAGTACTTGATGTAAA	rs150233738	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:17903234_17903235insTTACATCAGAGTACTTGATGTAAA	ENST00000514771.1	+	0	283																											ctgctcagagtttACATCAGAG	0.347													4	3	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21534245	21534246	+	RNA	INS	-	-	TG	rs143137704		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:21534245_21534246insTG	ENST00000607545.1	+	0	314					NR_027026.1																						GCAGGTGTGTCTGTCACAAACA	0.520													5	4	---	---	---	---					
RP11-506H20.1	0	broad.mit.edu	37	5	54541151	54541152	+	RNA	INS	-	-	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:54541151_54541152insG	ENST00000506435.1	+	0	107																											gtttggatcatggggggaagat	0.470													2	4	---	---	---	---					
CTC-340D7.1	0	broad.mit.edu	37	5	68180205	68180205	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:68180205delG	ENST00000503268.1	-	0	377																		p.0?(1)									CAGAAATCCTGGGCTGAATTT	0.398													2	4	---	---	---	---					
RP11-168A11.1	0	broad.mit.edu	37	5	79263156	79263157	+	RNA	INS	-	-	A	rs141009666	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:79263156_79263157insA	ENST00000503167.1	+	0	521																											ccagggattggaaaggcaagca	0.490													3	5	---	---	---	---					
TMEM161B-AS1	100505894	broad.mit.edu	37	5	87621204	87621204	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:87621204delT	ENST00000501715.2	+	0	577				TMEM161B-AS1_ENST00000501869.2_RNA|TMEM161B-AS1_ENST00000510087.1_RNA|TMEM161B-AS1_ENST00000504922.1_RNA																							tttgtttgtgttttttttaag	0.468													2	4	---	---	---	---					
LINC01183	728586	broad.mit.edu	37	5	127108159	127108159	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:127108159delA	ENST00000514853.2	+	0	278																											actctgtcacaaaaaaaaaaa	0.463													2	4	---	---	---	---					
CTC-575N7.1	0	broad.mit.edu	37	5	129135167	129135168	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:129135167_129135168insT	ENST00000503616.1	-	0	121				CTC-575N7.1_ENST00000515569.1_RNA																							accaggtggggtttttttcccc	0.470													2	4	---	---	---	---					
CTC-575N7.1	0	broad.mit.edu	37	5	129157933	129157934	+	RNA	INS	-	-	T	rs71991443		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:129157933_129157934insT	ENST00000503616.1	-	0	121				CTC-575N7.1_ENST00000515569.1_RNA																							TGCTCTGGGGCTTTTTTTTTTT	0.356													5	4	---	---	---	---					
CTC-359M8.1	0	broad.mit.edu	37	5	145741114	145741115	+	RNA	DEL	CT	CT	-	rs5871964		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:145741114_145741115delCT	ENST00000515598.1	-	0	403				CTC-359M8.1_ENST00000511390.1_RNA																							gcctgtaatgctctagcacttt	0.485													4	5	---	---	---	---					
CTB-11I22.1	0	broad.mit.edu	37	5	158648147	158648148	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:158648147_158648148insT	ENST00000521204.1	+	0	191																											tatttgtttccttttttttttc	0.416													2	4	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	163814220	163814221	+	RNA	INS	-	-	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr5:163814220_163814221insA	ENST00000486913.3	+	0	85				CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000519329.1_RNA|CTC-340A15.2_ENST00000524297.1_RNA|CTC-340A15.2_ENST00000523648.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000517508.1_RNA|CTC-340A15.2_ENST00000523704.1_RNA|CTC-340A15.2_ENST00000522686.1_RNA																							ggatgggagggagggaggaagg	0.465													2	4	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32521545	32521546	+	RNA	INS	-	-	AAGG	rs144810212	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:32521545_32521546insAAGG	ENST00000411500.1	-	0	851					NR_001298.1																						TTGGGGAAAGACTTTATCCAGG	0.436													3	3	---	---	---	---					
LOC101929705	101929705	broad.mit.edu	37	6	43997159	43997160	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:43997159_43997160insT	ENST00000422059.1	-	0	156																											CCATCTTCCCCTTTTGCCACAT	0.520													2	4	---	---	---	---					
LOC101929705	101929705	broad.mit.edu	37	6	44012553	44012554	+	RNA	DEL	AC	AC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:44012553_44012554delAC	ENST00000422059.1	-	0	156																											acattcatatacacacattcat	0.396													3	5	---	---	---	---					
COL19A1	1310	broad.mit.edu	37	6	70637869	70637869	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:70637869delC	ENST00000322773.4	+	5	437	c.335delC	c.(334-336)gcfs	p.A112fs		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	112	TSP N-terminal.			FRVRRNAKKERWFL -> ETTVPFWRFFVLET (in Ref. 6; AAA36358).	cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CGAAGAAACGCCAAAAAGGAA	0.428													18	123	---	---	---	---					
RP11-554D15.3	0	broad.mit.edu	37	6	75430834	75430834	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:75430834delT	ENST00000432484.2	-	0	199																											ttgtggcctctagagtttctg	0.333													2	4	---	---	---	---					
RP11-436D23.1	0	broad.mit.edu	37	6	98463864	98463864	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:98463864delC	ENST00000607823.1	+	0	267																											CACTCTGTCTCCCAGTATTTC	0.338													2	4	---	---	---	---					
STXBP5-AS1	729178	broad.mit.edu	37	6	147247909	147247910	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:147247909_147247910insT	ENST00000367477.3	-	0	695				STXBP5-AS1_ENST00000427394.1_RNA|STXBP5-AS1_ENST00000458125.1_RNA|STXBP5-AS1_ENST00000447072.1_RNA|STXBP5-AS1_ENST00000431143.1_RNA																							ctgtatgtcactttttttggtc	0.421													2	4	---	---	---	---					
SAMD5	389432	broad.mit.edu	37	6	148036656	148036662	+	RNA	DEL	AGCTCCT	AGCTCCT	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:148036656_148036662delAGCTCCT	ENST00000427015.1	+	0	117																											ttgttcagggagctcctaggtctgggt	0.580													4	3	---	---	---	---					
LOC102724087	102724087	broad.mit.edu	37	6	161374474	161374475	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr6:161374474_161374475insT	ENST00000417479.1	+	0	293																											CTTGTTTTACATTTTTTTGATA	0.297													2	4	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11369183	11369186	+	RNA	DEL	TGCG	TGCG	-	rs58067291		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:11369183_11369186delTGCG	ENST00000421121.1	+	0	113				AC004538.3_ENST00000445839.1_RNA|AC004538.3_ENST00000599875.1_RNA|AC004538.3_ENST00000428967.1_RNA																							tgtgtgtgcctgcgtgcgtgtgtg	0.471													4	3	---	---	---	---					
LOC101927630	101927630	broad.mit.edu	37	7	17526778	17526779	+	RNA	INS	-	-	A	rs144199005	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:17526778_17526779insA	ENST00000451792.1	-	0	158																											AGGATTGAAGGAAAAAAAAATA	0.371													2	4	---	---	---	---					
AC004485.3	0	broad.mit.edu	37	7	24248753	24248754	+	RNA	INS	-	-	A	rs149706692	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:24248753_24248754insA	ENST00000439839.1	-	0	159																											TGCAATAGTACAGCCATGCCAT	0.361													6	2	---	---	---	---					
LOC100506289	100506289	broad.mit.edu	37	7	26592328	26592329	+	RNA	INS	-	-	GTGCACACACACGCCC	rs141907807	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:26592328_26592329insGTGCACACACACGCCC	ENST00000420912.1	+	0	389																											TACGTGTGCCTGTGcacacaca	0.520													3	5	---	---	---	---					
TRGC2	6967	broad.mit.edu	37	7	38284885	38284886	+	RNA	INS	-	-	GGGT	rs138091320	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:38284885_38284886insGGGT	ENST00000436911.2	-	0	330																											TATTTGTCAAGgtgtgtgtgtg	0.391													29	67	---	---	---	---					
POLR2J4	84820	broad.mit.edu	37	7	44056176	44056177	+	RNA	DEL	CT	CT	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:44056176_44056177delCT	ENST00000427076.1	-	0	89					NR_003655.2																						TCCTCCCACCCTGAGTCTAAAC	0.559													4	6	---	---	---	---					
AC004901.1	0	broad.mit.edu	37	7	46953635	46953636	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:46953635_46953636insT	ENST00000433337.1	-	0	301																											tgtctctgctgtttttttgggt	0.327													2	4	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72080333	72080334	+	RNA	INS	-	-	GA	rs144937533	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:72080333_72080334insGA	ENST00000438125.1	-	0	1399							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										tggactagagggagagaaggct	0.376													3	5	---	---	---	---					
AC003988.1	0	broad.mit.edu	37	7	79900791	79900791	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:79900791delT	ENST00000447198.2	-	0	202																											acccggctaattttttttttg	0.498													2	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89670143	89670143	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:89670143delA	ENST00000478318.2	-	0	424																											tttatcttataaggatacatg	0.383													2	4	---	---	---	---					
LOC101927497	101927497	broad.mit.edu	37	7	92484035	92484036	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:92484035_92484036insT	ENST00000435695.1	+	0	81				AC002454.1_ENST00000452050.1_RNA																							TGCTCTCGTGCTTTTTTTTCTG	0.446													3	4	---	---	---	---					
AC003088.1	0	broad.mit.edu	37	7	110111400	110111401	+	RNA	INS	-	-	AAGG	rs4993604	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:110111400_110111401insAAGG	ENST00000435466.1	-	0	327																											agaaagaaagaaaggaaggaag	0.421													2	4	---	---	---	---					
RP11-560I19.1	0	broad.mit.edu	37	7	121858099	121858100	+	RNA	INS	-	-	G	rs150662047	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:121858099_121858100insG	ENST00000446053.1	+	0	176																											aaatggggagtgggggggtggg	0.455													3	5	---	---	---	---					
POT1-AS1	401398	broad.mit.edu	37	7	124612519	124612520	+	RNA	INS	-	-	CACA	rs150291617	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:124612519_124612520insCACA	ENST00000453342.1	+	0	202																											tctctctctctcacacacacac	0.441													3	5	---	---	---	---					
LINC-PINT	378805	broad.mit.edu	37	7	130668826	130668826	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:130668826delA	ENST00000451786.1	-	0	1821																											TCAGTGGTTTATTCTGCTTCA	0.318													2	4	---	---	---	---					
LOC101928782	101928782	broad.mit.edu	37	7	131606782	131606782	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:131606782delC	ENST00000415393.1	+	0	352				AC009518.4_ENST00000452219.1_RNA																							GTGATGCTATCCCCCCCTTCA	0.428													2	4	---	---	---	---					
AC009784.3	0	broad.mit.edu	37	7	136121264	136121264	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:136121264delT	ENST00000445293.2	+	0	777																											ttcttttccattttttttggc	0.313													2	4	---	---	---	---					
LOC349160	349160	broad.mit.edu	37	7	136445085	136445086	+	RNA	INS	-	-	T	rs34228645	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr7:136445085_136445086insT	ENST00000586239.1	-	0	466				AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000598184.1_RNA																							GAGTTCTCAAGTTTTTTTTGCC	0.327													2	4	---	---	---	---					
CTD-2281E23.2	0	broad.mit.edu	37	8	1204689	1204690	+	RNA	DEL	CT	CT	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:1204689_1204690delCT	ENST00000522989.1	+	0	200																											TCCCAGGAACCTCCTGCCTTAG	0.465													3	4	---	---	---	---					
RP11-124B13.1	0	broad.mit.edu	37	8	6078275	6078275	+	RNA	DEL	C	C	-	rs140981182	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:6078275delC	ENST00000519555.1	-	0	126																											cagtggctcacgcctgtaatc	0.498													4	3	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24734995	24734996	+	RNA	INS	-	-	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:24734995_24734996insA	ENST00000519689.1	-	0	184																											aagtcaatctgaaaaaactaca	0.401													2	4	---	---	---	---					
LOC101929470	101929470	broad.mit.edu	37	8	29677809	29677815	+	RNA	DEL	ACCACAC	ACCACAC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:29677809_29677815delACCACAC	ENST00000507496.1	-	0	578																											cactaattgtaccacacaccacacaca	0.469													7	11	---	---	---	---					
RP11-489E7.1	0	broad.mit.edu	37	8	29766188	29766191	+	RNA	DEL	AAAA	AAAA	-	rs35298008		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:29766188_29766191delAAAA	ENST00000521908.1	+	0	266_269																											ggaaggaaggaaaagaaagaaaag	0.461													2	4	---	---	---	---					
RP11-473J6.1	0	broad.mit.edu	37	8	35762286	35762287	+	RNA	INS	-	-	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:35762286_35762287insC	ENST00000523748.1	+	0	366																											CTCCTACCTTACCCCCTGCTGC	0.351													2	4	---	---	---	---					
RP11-473J6.1	0	broad.mit.edu	37	8	35816935	35816935	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:35816935delA	ENST00000523748.1	+	0	525																											cgagtctgtgaaaaattcaac	0.428													2	4	---	---	---	---					
RP11-150O12.4	0	broad.mit.edu	37	8	37474627	37474627	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:37474627delT	ENST00000517714.1	-	0	135																											TCATTGGGCCTTTTGCCTTTG	0.333													2	4	---	---	---	---					
POTEA	340441	broad.mit.edu	37	8	43182571	43182572	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:43182571_43182572insT	ENST00000522175.2	+	0	1051							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						cagtgatagcattttttcatgt	0.361													2	4	---	---	---	---					
RP11-386D6.2	0	broad.mit.edu	37	8	87799792	87799793	+	RNA	INS	-	-	T	rs151236421	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:87799792_87799793insT	ENST00000520649.1	+	0	449																											AGTTTTCTTTGTTTTTTTTTTC	0.327													2	4	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89560972	89560973	+	RNA	INS	-	-	C	rs72042584	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:89560972_89560973insC	ENST00000521433.1	+	0	310				RP11-586K2.1_ENST00000520312.1_RNA|RP11-586K2.1_ENST00000518631.1_RNA																							AGCGCAATCAGCCTGTTACCTT	0.421													4	2	---	---	---	---					
LOC102724710	102724710	broad.mit.edu	37	8	93639004	93639004	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:93639004delA	ENST00000523284.1	-	0	395																											tgatcacatgaaaaaagaagt	0.408													2	4	---	---	---	---					
PCAT2	103164619	broad.mit.edu	37	8	128088696	128088697	+	RNA	DEL	TG	TG	-	rs57692450		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr8:128088696_128088697delTG	ENST00000523510.1	-	0	350																											tctctctctttgtgtgtgtgtg	0.480													4	3	---	---	---	---					
MIR31HG	554202	broad.mit.edu	37	9	21505284	21505285	+	RNA	INS	-	-	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:21505284_21505285insG	ENST00000304425.3	-	0	181					NR_027054.1																						cacagccatttggggggattta	0.396													3	3	---	---	---	---					
FRMD3	257019	broad.mit.edu	37	9	86153111	86153111	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:86153111delC	ENST00000304195.3	-	1	242	c.36delG	c.(34-36)agfs	p.R13fs	FRMD3_ENST00000376438.1_Frame_Shift_Del_p.R13fs	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	13						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						TCATGGTCCTCCTGCCTCTCG	0.652													2	4	---	---	---	---					
RP11-305L7.3	0	broad.mit.edu	37	9	93901365	93901366	+	RNA	INS	-	-	GTGTGC	rs74750201	byFrequency	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr9:93901365_93901366insGTGTGC	ENST00000457976.1	-	0	83																											CATGCAtgtgtgtgtgcgtgtg	0.470													4	3	---	---	---	---					
LOC101929352	101929352	broad.mit.edu	37	10	31484723	31484724	+	RNA	DEL	AT	AT	-	rs144250187		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:31484723_31484724delAT	ENST00000605929.1	+	0	317																											GATTATACAAATATATATATAC	0.356													3	3	---	---	---	---					
RP11-508N22.8	0	broad.mit.edu	37	10	38465943	38465944	+	RNA	INS	-	-	A	rs143315836	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:38465943_38465944insA	ENST00000423162.1	+	0	293				RP11-508N22.9_ENST00000419779.1_lincRNA																							aacttaaagtgaaaaaaaaaaC	0.332													3	4	---	---	---	---					
LINC01468	101928687	broad.mit.edu	37	10	54211885	54211885	+	RNA	DEL	T	T	-	rs55748115		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:54211885delT	ENST00000435813.2	-	0	331																											AAATTATGCCTTTTTTTTTTT	0.323													2	4	---	---	---	---					
RP11-491H19.1	0	broad.mit.edu	37	10	63557422	63557425	+	RNA	DEL	CACC	CACC	-	rs1318170	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:63557422_63557425delCACC	ENST00000441001.2	-	0	122																											cacacacacacacCCCATGTCAGG	0.500													4	5	---	---	---	---					
ZMIZ1-AS1	283050	broad.mit.edu	37	10	80783202	80783202	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:80783202delC	ENST00000456353.1	-	0	1012					NR_024431.2																						gaaatggtctccaaggtcaca	0.502													2	4	---	---	---	---					
LOC283038	283038	broad.mit.edu	37	10	127386715	127386715	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr10:127386715delG	ENST00000415305.2	+	0	260					NR_033848.1																						GAGCCCACCAGGAAGACCCCG	0.542													3	3	---	---	---	---					
CTC-497E21.5	0	broad.mit.edu	37	11	13125535	13125536	+	RNA	INS	-	-	AAGA	rs55714910		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:13125535_13125536insAAGA	ENST00000531136.1	-	0	47																											gaaaaagaaagaagaaagaaag	0.342													6	3	---	---	---	---					
RP11-460B17.3	0	broad.mit.edu	37	11	29604287	29604288	+	RNA	INS	-	-	AA			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:29604287_29604288insAA	ENST00000525097.1	-	0	70																											aggatgggatgaaaaactacct	0.426													2	4	---	---	---	---					
CTD-3138F19.1	0	broad.mit.edu	37	11	29800367	29800370	+	RNA	DEL	ACAT	ACAT	-	rs2680287		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:29800367_29800370delACAT	ENST00000530249.1	+	0	232																											acacacacacacatgcaaacatgc	0.436													3	4	---	---	---	---					
RP11-124G5.3	0	broad.mit.edu	37	11	41554377	41554387	+	RNA	DEL	TGTGTGTGTGT	TGTGTGTGTGT	-	rs59572555		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:41554377_41554387delTGTGTGTGTGT	ENST00000526978.1	-	0	519																											atgttgtgggtgtgtgtgtgtgtgtgtgtgt	0.370													2	4	---	---	---	---					
RP11-958J22.1	0	broad.mit.edu	37	11	45546632	45546633	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:45546632_45546633insT	ENST00000533315.1	-	0	490																											ccttctctatcttttttggctt	0.411													2	4	---	---	---	---					
LOC101928443	101928443	broad.mit.edu	37	11	69908574	69908575	+	RNA	INS	-	-	C			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:69908574_69908575insC	ENST00000511013.2	-	0	1449																											AGGATCCTGCACCCCCCAGTAG	0.505													2	4	---	---	---	---					
ENPP7P8	100421860	broad.mit.edu	37	11	71432047	71432048	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:71432047_71432048insT	ENST00000529093.1	+	0	262																											GCAGCtttttattttttttttc	0.396													4	4	---	---	---	---					
LOC102723895	102723895	broad.mit.edu	37	11	104366318	104366319	+	RNA	INS	-	-	ACAC	rs71701571		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:104366318_104366319insACAC	ENST00000536529.1	-	0	507																											ATAAGTTTTCTacacacacaca	0.347													3	3	---	---	---	---					
LOC102723895	102723895	broad.mit.edu	37	11	104366351	104366352	+	RNA	DEL	AA	AA	-	rs28699549		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:104366351_104366352delAA	ENST00000536529.1	-	0	507																											acacacacacaaacaccacaTT	0.351													5	1	---	---	---	---					
RP11-94P11.4	0	broad.mit.edu	37	11	105391445	105391446	+	RNA	INS	-	-	CAC	rs145225089	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:105391445_105391446insCAC	ENST00000528811.1	-	0	96																											AGTATGCTCAAATTTGTACCTC	0.327													6	2	---	---	---	---					
LOC101928823	101928823	broad.mit.edu	37	11	112369243	112369243	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:112369243delG	ENST00000528496.1	+	0	231																											ttctaagtgagggggctggct	0.438													2	4	---	---	---	---					
TMPRSS4-AS1	100526771	broad.mit.edu	37	11	117907820	117907821	+	RNA	INS	-	-	C	rs150598905	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr11:117907820_117907821insC	ENST00000606951.1	-	0	195				TMPRSS4-AS1_ENST00000527329.1_RNA|TMPRSS4-AS1_ENST00000527695.1_RNA	NR_038318.1																						tgtctctcagtcccccctctca	0.530													2	4	---	---	---	---					
RP11-1038A11.3	0	broad.mit.edu	37	12	5415687	5415688	+	RNA	INS	-	-	T	rs138647843	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:5415687_5415688insT	ENST00000537192.1	+	0	219																											TGTAGGGTCTCTATCACCTGAG	0.450													3	3	---	---	---	---					
RP11-174G6.1	0	broad.mit.edu	37	12	14875687	14875690	+	RNA	DEL	AGAT	AGAT	-	rs11056137		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:14875687_14875690delAGAT	ENST00000501178.2	+	0	288																											acagacagacagatagatagatag	0.417													2	4	---	---	---	---					
LOC100288798	100288798	broad.mit.edu	37	12	46785348	46785348	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:46785348delC	ENST00000551503.1	+	0	261																											GGGTTAAGGTCCTGCTGAACC	0.358													2	4	---	---	---	---					
FLJ41278	400046	broad.mit.edu	37	12	65314893	65314893	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:65314893delT	ENST00000535058.1	+	0	594				RP11-766N7.4_ENST00000510459.2_lincRNA	NR_033988.1																						ttttctttccttttttttttc	0.433													2	4	---	---	---	---					
FLJ41278	400046	broad.mit.edu	37	12	65370487	65370487	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:65370487delT	ENST00000535058.1	+	0	2731				RP11-766N7.4_ENST00000510459.2_lincRNA	NR_033988.1																						CTGATGGCGCTTTTTTTTTTT	0.328													2	4	---	---	---	---					
LOC100507065	100507065	broad.mit.edu	37	12	66025065	66025065	+	RNA	DEL	A	A	-	rs67192189		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:66025065delA	ENST00000546198.1	-	0	104																											ACTTAAGGTTAAAAAAAAAAA	0.358													2	4	---	---	---	---					
LINC01481	101928062	broad.mit.edu	37	12	70537888	70537888	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:70537888delT	ENST00000549419.1	-	0	144																											aaggtttagattttttttttt	0.423													3	4	---	---	---	---					
LINC01481	101928062	broad.mit.edu	37	12	70564091	70564092	+	RNA	INS	-	-	T	rs142169004	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:70564091_70564092insT	ENST00000549419.1	-	0	144																											AATTCATCTCATTTttttttca	0.312													2	4	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	74025058	74025059	+	RNA	INS	-	-	A	rs75690051		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:74025058_74025059insA	ENST00000549058.1	-	0	97																											agaagaagaagaaaaaaaagaa	0.426													2	4	---	---	---	---					
RP1-34H18.1	0	broad.mit.edu	37	12	77811330	77811330	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:77811330delC	ENST00000550042.1	+	0	574																											gttcttaagaccagaaatagc	0.363													2	4	---	---	---	---					
RP11-511B23.2	0	broad.mit.edu	37	12	93578035	93578036	+	RNA	DEL	GT	GT	-	rs61096511		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:93578035_93578036delGT	ENST00000547432.1	-	0	316				RP11-511B23.2_ENST00000549930.1_RNA																							gacagacagagtgtgtgtgtgt	0.480													2	4	---	---	---	---					
RP11-510I5.4	0	broad.mit.edu	37	12	96844320	96844320	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr12:96844320delA	ENST00000548740.1	-	0	226																											atagactgctagctggattaa	0.383													2	4	---	---	---	---					
LINC00423	100874167	broad.mit.edu	37	13	33467285	33467285	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:33467285delA	ENST00000421002.1	-	0	836					NR_047020.1																						TTAAAGAACCAAAGGATCCAG	0.413													2	4	---	---	---	---					
RP11-141M1.3	0	broad.mit.edu	37	13	34195949	34195950	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:34195949_34195950insT	ENST00000454681.2	-	0	91																											atttttttttcttttttttttg	0.411													2	4	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	78513106	78513108	+	RNA	DEL	CAC	CAC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:78513106_78513108delCAC	ENST00000607862.1	+	0	230																											tgagtcacagcaccaaaTTtcat	0.507													7	3	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	79154605	79154606	+	RNA	INS	-	-	A			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:79154605_79154606insA	ENST00000607862.1	+	0	2309_2310				RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000606376.1_RNA																							ACCCCCTCCCCAAAAACTCCCT	0.480													2	4	---	---	---	---					
MIR4500HG	642345	broad.mit.edu	37	13	88270841	88270843	+	RNA	DEL	TGT	TGT	-	rs72394410		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr13:88270841_88270843delTGT	ENST00000436290.2	-	0	128					NR_033829.1																						ATGTCCTCCCtgttgttgttgtt	0.374													6	2	---	---	---	---					
CTD-2555K7.2	0	broad.mit.edu	37	14	23211218	23211225	+	RNA	DEL	AGAAAGAG	AGAAAGAG	-	rs147068963	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:23211218_23211225delAGAAAGAG	ENST00000554857.1	-	0	139				CTD-2555K7.2_ENST00000553792.1_RNA																							aaagaaagaaagaaagagagagagagag	0.351													4	3	---	---	---	---					
CTD-2555K7.2	0	broad.mit.edu	37	14	23211222	23211223	+	RNA	DEL	AG	AG	-	rs147068963		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:23211222_23211223delAG	ENST00000554857.1	-	0	139				CTD-2555K7.2_ENST00000553792.1_RNA																							aaagaaagaaagagagagagag	0.351													3	4	---	---	---	---					
LOC102724917	102724917	broad.mit.edu	37	14	29324407	29324409	+	RNA	DEL	TTG	TTG	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:29324407_29324409delTTG	ENST00000551588.1	+	0	388																											attcttgttcttgttgttgttgt	0.369													2	4	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38562379	38562379	+	RNA	DEL	A	A	-	rs78462990		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:38562379delA	ENST00000554687.1	-	0	200																											ggactgaaagaaaaaaacaca	0.473													4	4	---	---	---	---					
LINC00639	283547	broad.mit.edu	37	14	39245243	39245243	+	RNA	DEL	G	G	-	rs58658237	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:39245243delG	ENST00000553932.1	-	0	3985																											TACTATAAAAGAAAAAGTTTA	0.318													2	4	---	---	---	---					
RP11-187O7.3	0	broad.mit.edu	37	14	77080507	77080507	+	RNA	DEL	G	G	-	rs77130664		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:77080507delG	ENST00000554926.1	-	0	194																											gtccccctgtgctaagctctt	0.478													3	3	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82410205	82410205	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:82410205delC	ENST00000554814.1	+	0	315																											ggagactgggccctttccaga	0.468													3	4	---	---	---	---					
GALC	2581	broad.mit.edu	37	14	88333266	88333266	+	RNA	DEL	G	G	-	rs56833560		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:88333266delG	ENST00000554305.1	-	0	17																											CTGAGTCCCTGGGAATGGTAT	0.413													5	4	---	---	---	---					
LINC01146	283587	broad.mit.edu	37	14	88497848	88497849	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr14:88497848_88497849insT	ENST00000556033.1	+	0	195				RP11-300J18.1_ENST00000553921.1_lincRNA	NR_046094.1																						tgacccatatgtttttttcagg	0.337													2	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22324100	22324101	+	RNA	INS	-	-	TCTT	rs150240589	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:22324100_22324101insTCTT	ENST00000558896.1	+	0	194																											ttctttctttctctttctttct	0.337													5	8	---	---	---	---					
AC009878.2	0	broad.mit.edu	37	15	26661270	26661271	+	RNA	INS	-	-	ACACACACACAC	rs60719081	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:26661270_26661271insACACACACACAC	ENST00000451579.1	+	0	173																											cacaaatggaaacacacacaca	0.381													3	4	---	---	---	---					
RP11-184D12.1	0	broad.mit.edu	37	15	36410484	36410485	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:36410484_36410485insT	ENST00000561394.1	-	0	136																											CACAAGAGATCTTTTTTggggc	0.401													2	4	---	---	---	---					
RP11-624L4.1	0	broad.mit.edu	37	15	39632734	39632735	+	RNA	INS	-	-	AC	rs10651881	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:39632734_39632735insAC	ENST00000559318.1	-	0	408				RP11-624L4.1_ENST00000558209.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA																							GAGAGacacatacacacacaca	0.401													3	4	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	84074480	84074481	+	RNA	INS	-	-	G	rs142284211	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:84074480_84074481insG	ENST00000565495.1	+	0	264																											tttcttcccttggggggggtct	0.386													2	4	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	88148150	88148150	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:88148150delA	ENST00000560439.1	-	0	80																											aaaagcagctaagggaagaga	0.443													2	4	---	---	---	---					
RP11-739G5.1	0	broad.mit.edu	37	15	94192187	94192187	+	RNA	DEL	A	A	-	rs72398766		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr15:94192187delA	ENST00000554318.2	+	0	324																											actctgtctcaaaaaaaaaaa	0.493													3	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5468081	5468082	+	RNA	INS	-	-	CAA	rs111446405	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:5468081_5468082insCAA	ENST00000569895.1	+	0	304																											aaactccatctcaacaacaaca	0.446													3	5	---	---	---	---					
LOC101927580	101927580	broad.mit.edu	37	16	59903556	59903556	+	RNA	DEL	A	A	-	rs34978391		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:59903556delA	ENST00000568279.1	+	0	173																											ccctgagtctaaaaaaaaagt	0.423													2	4	---	---	---	---					
LINC01572	101927957	broad.mit.edu	37	16	72627209	72627210	+	RNA	INS	-	-	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:72627209_72627210insG	ENST00000561611.2	-	0	113																											ACAGTGATAATGGGGGGGGGAA	0.361													2	4	---	---	---	---					
RP11-281J9.2	0	broad.mit.edu	37	16	78055210	78055210	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr16:78055210delG	ENST00000563114.1	-	0	41																											acaaaatcccggctcactgca	0.468													2	4	---	---	---	---					
AC005863.2	0	broad.mit.edu	37	17	14786065	14786065	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:14786065delT	ENST00000445035.2	+	0	659																											tgacctctgctttttttcgtt	0.343													2	4	---	---	---	---					
CTB-91J4.1	0	broad.mit.edu	37	17	34447119	34447120	+	RNA	INS	-	-	T	rs34850577	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:34447119_34447120insT	ENST00000592460.1	+	0	41																											ttatatcacccgtttgcctttg	0.401													3	5	---	---	---	---					
TBKBP1	9755	broad.mit.edu	37	17	45776772	45776773	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr17:45776772_45776773insG	ENST00000361722.3	+	5	1570_1571	c.721_722insG	c.(721-723)gggfs	p.G241fs		NM_014726.2	NP_055541.1	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	241					innate immune response					endometrium(5)|kidney(1)|lung(1)	7						GGGAGAGGCCCGGGGGGCTCAG	0.708											OREG0024498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
AQP4-AS1	147429	broad.mit.edu	37	18	24257667	24257668	+	RNA	INS	-	-	AGGAAG	rs146379818	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:24257667_24257668insAGGAAG	ENST00000582605.1	+	0	93				AQP4-AS1_ENST00000579964.1_RNA																							ggaggaggagaaggaagaggaa	0.396													4	4	---	---	---	---					
DSCAS	101927698	broad.mit.edu	37	18	28699063	28699064	+	RNA	INS	-	-	G			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:28699063_28699064insG	ENST00000581836.1	+	0	208																											CCTCATGAGGAGGGGGGCAGTG	0.436													2	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	39856071	39856072	+	RNA	DEL	AC	AC	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:39856071_39856072delAC	ENST00000593234.1	+	0	402					NR_046456.1																						TTTCTTGCCTacacacacacac	0.421													4	4	---	---	---	---					
ST8SIA5	29906	broad.mit.edu	37	18	44284556	44284571	+	Frame_Shift_Del	DEL	AATATTTCGTGCCTCA	AATATTTCGTGCCTCA	-	rs146980909		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:44284556_44284571delAATATTTCGTGCCTCA	ENST00000315087.7	-	2	848_863	c.188_203delTGAGGCACGAAATATT	c.(187-204)cgfs	p.LRHEIL63fs	ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000536490.1_Intron|ST8SIA5_ENST00000538168.1_Frame_Shift_Del_p.LRHEIL99fs	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	63					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						CTTCACTTCCAATATTTCGTGCCTCAGCTCCAGGCA	0.532													23	291	---	---	---	---					
RP11-325K19.1	0	broad.mit.edu	37	18	58529787	58529788	+	RNA	INS	-	-	TA			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:58529787_58529788insTA	ENST00000591869.1	-	0	38																											aatgtgatatgtatatatacac	0.297													2	4	---	---	---	---					
LINC01538	400654	broad.mit.edu	37	18	61914863	61914864	+	RNA	DEL	TC	TC	-	rs57415273		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:61914863_61914864delTC	ENST00000588074.1	-	0	443				RP11-146N18.1_ENST00000589376.1_lincRNA	NR_033983.1																						agggcataaatctctctgcttc	0.421													2	4	---	---	---	---					
RP11-775G23.1	0	broad.mit.edu	37	18	63303257	63303257	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr18:63303257delT	ENST00000579862.1	+	0	571																											cagacaaacctagtttgtcag	0.468													3	3	---	---	---	---					
CTD-2050I18.1	0	broad.mit.edu	37	19	32038085	32038086	+	RNA	INS	-	-	AA	rs76342674		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:32038085_32038086insAA	ENST00000593063.1	+	0	282																											gaccctgtctcaaaaaaaaaaa	0.480													2	4	---	---	---	---					
CTD-2050I18.1	0	broad.mit.edu	37	19	32038927	32038928	+	RNA	INS	-	-	ATCCATCA	rs148321945	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:32038927_32038928insATCCATCA	ENST00000593063.1	+	0	282																											tccatccatccatccatccatc	0.515													5	3	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57217946	57217947	+	RNA	INS	-	-	A	rs143551034	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr19:57217946_57217947insA	ENST00000597822.1	+	0	60																											GGATGAATCAGAAAAAAAAAGA	0.391													2	4	---	---	---	---					
SNAP25-AS1	100131208	broad.mit.edu	37	20	10194561	10194561	+	RNA	DEL	C	C	-	rs33925489		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:10194561delC	ENST00000603542.1	-	0	518				SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25-AS1_ENST00000451151.1_RNA|SNAP25-AS1_ENST00000426491.1_RNA|SNAP25-AS1_ENST00000605592.1_RNA	NR_040710.1																						GTCCTTTGGACCATGACCAAG	0.473													4	3	---	---	---	---					
FAM182A	284800	broad.mit.edu	37	20	26054795	26054796	+	RNA	INS	-	-	CAT	rs112274107		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:26054795_26054796insCAT	ENST00000376398.2	+	0	819					NR_026713.1															breast(1)|endometrium(2)|kidney(1)	4						accattctcaccatcatcctca	0.406													2	4	---	---	---	---					
NCOR1P1	149934	broad.mit.edu	37	20	26088971	26088971	+	RNA	DEL	A	A	-	rs76867961	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:26088971delA	ENST00000478176.1	-	0	150					NR_003678.1																						CAGTATGCTTAAAAAAAAAGA	0.338													4	6	---	---	---	---					
RP4-550H1.4	0	broad.mit.edu	37	20	34662505	34662505	+	RNA	DEL	T	T	-	rs112453762		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr20:34662505delT	ENST00000430679.2	+	0	404																											GGCATCCTGCttttttttttt	0.542													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11039939	11039941	+	RNA	DEL	GTT	GTT	-	rs146620410		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:11039939_11039941delGTT	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGATATAATCGTTGTTCTTCATC	0.320													3	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11079710	11079711	+	RNA	INS	-	-	TA	rs74711197		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:11079710_11079711insTA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aatttttttttaaaGCAAATTC	0.406													6	4	---	---	---	---					
MIR99AHG	388815	broad.mit.edu	37	21	17531876	17531876	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:17531876delA	ENST00000458468.1	+	0	312					NR_027790.1																						ACTAAGAGTCAAGCGCTTGCC	0.398													2	4	---	---	---	---					
MIR99AHG	388815	broad.mit.edu	37	21	17923941	17923941	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:17923941delT	ENST00000458468.1	+	0	579					NR_027790.1																						aaagctgaccttttcatcagt	0.378													2	4	---	---	---	---					
LOC101927797	101927797	broad.mit.edu	37	21	20017691	20017691	+	RNA	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:20017691delA	ENST00000416002.1	+	0	286				AL109763.2_ENST00000437492.1_RNA																							agaggggtagaggaatactca	0.368													2	4	---	---	---	---					
AP000705.7	0	broad.mit.edu	37	21	23782112	23782113	+	RNA	INS	-	-	CCTC	rs28427129	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:23782112_23782113insCCTC	ENST00000444130.1	+	0	385																											cttccttccttccttccttcct	0.376													4	7	---	---	---	---					
AP000318.2	0	broad.mit.edu	37	21	35601499	35601502	+	RNA	DEL	AGGA	AGGA	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:35601499_35601502delAGGA	ENST00000427022.1	+	0	311																											ggagggagggaggaaggaaggaag	0.529													3	3	---	---	---	---					
AP000318.2	0	broad.mit.edu	37	21	35625280	35625281	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr21:35625280_35625281insT	ENST00000427022.1	+	0	311																											CGAAATTTCCATTTTTTTTTTC	0.396													3	4	---	---	---	---					
LOC102724900	102724900	broad.mit.edu	37	22	27767911	27767913	+	RNA	DEL	AGA	AGA	-	rs141064058		TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chr22:27767911_27767913delAGA	ENST00000413244.1	+	0	491																											agaggagaatagaaggagagaga	0.458													3	5	---	---	---	---					
MID1	4281	broad.mit.edu	37	X	11040212	11040212	+	RNA	DEL	G	G	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:11040212delG	ENST00000433747.2	-	0	423																											aatttggcatgttttgcagtg	0.418													3	5	---	---	---	---					
LINC01281	286442	broad.mit.edu	37	X	39171333	39171333	+	RNA	DEL	T	T	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:39171333delT	ENST00000448597.1	-	0	302					NR_038968.1																						CAATAGGCACTtttttttttc	0.473													2	4	---	---	---	---					
TAF1	6872	broad.mit.edu	37	X	70595026	70595026	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:70595026delA	ENST00000449580.1	+	4	473	c.422delA	c.(421-423)gafs	p.E141fs	TAF1_ENST00000373790.4_Frame_Shift_Del_p.E141fs|TAF1_ENST00000276072.3_Frame_Shift_Del_p.E141fs|TAF1_ENST00000423759.1_Frame_Shift_Del_p.E141fs			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	141	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GATTATGATGAAGATGACTAT	0.388													10	78	---	---	---	---					
GS1-256O22.5	0	broad.mit.edu	37	X	142532906	142532906	+	RNA	DEL	C	C	-			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:142532906delC	ENST00000431432.1	+	0	268																											gtgtgttgttccccccatgtg	0.468													2	4	---	---	---	---					
GS1-256O22.5	0	broad.mit.edu	37	X	142594436	142594437	+	RNA	DEL	GC	GC	-	rs71966790	by1000genomes	TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:142594436_142594437delGC	ENST00000431432.1	+	0	268																											ttaaaatttggcgtgtgtgtgt	0.347													6	5	---	---	---	---					
LINC00894	100272228	broad.mit.edu	37	X	149262274	149262275	+	RNA	INS	-	-	T			TCGA-17-Z018-01A-01W-0746-08	TCGA-17-Z018-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd1a61eb-8362-41a9-952d-b7e6887457ad	2bf636b9-7a27-4bda-bed6-cf9da71c2c2d	g.chrX:149262274_149262275insT	ENST00000449111.1	+	0	2830																											TATGTCCCAGCTTTTTTTCTTT	0.356													2	4	---	---	---	---					
