Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SEMA4A	64218	broad.mit.edu	37	1	156144918	156144918	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:156144918G>T	ENST00000368285.3	+	13	1743	c.1476G>T	c.(1474-1476)gtG>gtT	p.V492V	SEMA4A_ENST00000368284.1_Silent_p.V360V|SEMA4A_ENST00000368282.1_Silent_p.V492V|SEMA4A_ENST00000368286.2_Silent_p.V360V|SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000355014.2_Silent_p.V492V	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	492	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					TCTGGAGGGTGCCCCGAGCCA	0.592000													93	452					1.10825e-40	2.06834e-40	0.014410	1	0
WEE2	494551	broad.mit.edu	37	7	141424003	141424003	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:141424003C>A	ENST00000397541.2	+	8	1555	c.1149C>A	c.(1147-1149)caC>caA	p.H383Q	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	383	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity	p.H383H(1)		breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					ACCTGGGCCACGCAACATCAA	0.348000													29	35					2.14196e-07	2.92009e-07	0.007291	1	0
SI	6476	broad.mit.edu	37	3	164735848	164735848	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:164735848G>T	ENST00000264382.3	-	29	3492	c.3430C>A	c.(3430-3432)Ctt>Att	p.L1144I		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1144	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGGAATTAAGTTTGTACTGA	0.308000										HNSCC(35;0.089)			9	16					0.00621372	0.00671389	0.006214	1	0
SPEG	10290	broad.mit.edu	37	2	220333907	220333907	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:220333907C>A	ENST00000312358.7	+	13	3653	c.3521C>A	c.(3520-3522)cCc>cAc	p.P1174H	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1174					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCATCCATTCCCGAGGAGCCA	0.662000													3	6					3.59834e-05	4.37568e-05	0.001168	1	0
CEP350	9857	broad.mit.edu	37	1	180013210	180013210	+	Silent	SNP	T	T	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:180013210T>G	ENST00000367607.3	+	21	4942	c.4524T>G	c.(4522-4524)tcT>tcG	p.S1508S		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1508	Ser-rich.					centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TTTCACTCTCTCAGAGTAAAG	0.318000													6	12					0	0	0.001984	0	0
WISP1	8840	broad.mit.edu	37	8	134237689	134237689	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:134237689T>A	ENST00000250160.6	+	4	773	c.667T>A	c.(667-669)Tgg>Agg	p.W223R	WISP1_ENST00000377863.2_Missense_Mutation_p.W51R|WISP1_ENST00000517423.1_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000220856.6_Missense_Mutation_p.W136R	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	223	TSP type-1.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CACAAGCCCCTGGAGCCCTTG	0.592000													10	85					0	0	0.020292	0	0
C19orf45	374877	broad.mit.edu	37	19	7570505	7570505	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:7570505A>G	ENST00000361664.2	+	6	1139	c.998A>G	c.(997-999)tAc>tGc	p.Y333C		NM_198534.2	NP_940936.2	Q8NA69	CS045_HUMAN	chromosome 19 open reading frame 45	333										endometrium(1)|kidney(1)|liver(1)|lung(2)|ovary(2)|stomach(1)	8						CAGTACTTCTACGGCCAggtg	0.557000													10	44					0	0	0.006214	0	0
NOD2	64127	broad.mit.edu	37	16	50744599	50744599	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:50744599C>A	ENST00000300589.2	+	4	882	c.777C>A	c.(775-777)gtC>gtA	p.V259V	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	259					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TCCTGGAGGTCTGGGCAGATG	0.607000													5	20					3.59834e-05	4.37568e-05	0.001168	1	0
ANKRD1	27063	broad.mit.edu	37	10	92677534	92677534	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:92677534C>A	ENST00000371697.3	-	5	755	c.507G>T	c.(505-507)gtG>gtT	p.V169V		NM_014391.2	NP_055206.2	Q15327	ANKR1_HUMAN	ankyrin repeat domain 1 (cardiac muscle)	169					cellular lipid metabolic process|defense response|signal transduction		DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|prostate(3)|skin(1)	27		Colorectal(252;0.0475)				TTAACTTCTCCACAATTGCCA	0.363000													18	52					5.49717e-05	6.6615e-05	0.018920	1	0
ADCY3	109	broad.mit.edu	37	2	25059851	25059851	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:25059851C>T	ENST00000260600.5	-	8	2448	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	ADCY3_ENST00000405392.1_Missense_Mutation_p.E166K	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	533					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CCGTTGGGCTCCTTGGTCTCA	0.627000													3	10					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9058462	9058462	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:9058462T>A	ENST00000397910.4	-	3	29187	c.28984A>T	c.(28984-28986)Atc>Ttc	p.I9662F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9664	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGTGGTGATGGTTATTTCT	0.498000													19	61					0	0	0.006122	0	0
TMEM145	284339	broad.mit.edu	37	19	42827826	42827826	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:42827826G>T	ENST00000301204.3	+	14	1327	c.1286G>T	c.(1285-1287)gGg>gTg	p.G429V		NM_173633.2	NP_775904.2	Q8NBT3	TM145_HUMAN	transmembrane protein 145	429						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GGACCCGGAGGGAGCCAATCC	0.617000													9	32					5.4927e-09	8.02073e-09	0.004482	1	0
UBR5	51366	broad.mit.edu	37	8	103338891	103338891	+	Splice_Site	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:103338891C>A	ENST00000520539.1	-	13	2088	c.1481_splice	c.e13-1	p.W494_splice	UBR5_ENST00000220959.4_Splice_Site_p.W494_splice|UBR5_ENST00000521922.1_Splice_Site_p.W488_splice	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	494					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GAACTACACCCCTGAAAACAA	0.328000													9	57					0.000274275	0.000315914	0.004482	1	0
ULK2	9706	broad.mit.edu	37	17	19705198	19705198	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:19705198C>A	ENST00000395544.4	-	16	1832	c.1333G>T	c.(1333-1335)Ggc>Tgc	p.G445C	ULK2_ENST00000361658.2_Missense_Mutation_p.G445C|ULK2_ENST00000580130.1_5'UTR	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	445					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					CGGAGGAAGCCCATGGGGCTG	0.493000													88	95					2.78983e-34	5.179e-34	0.014410	1	0
TRGV3	6976	broad.mit.edu	37	7	38398612	38398612	+	RNA	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:38398612G>T	ENST00000390346.2	-	0	151																											GAAGGAAACGGACCAGATGAA	0.552000													16	63					3.5997e-14	6.09852e-14	0.014323	1	0
C1orf87	127795	broad.mit.edu	37	1	60520941	60520941	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:60520941G>T	ENST00000371201.3	-	3	384	c.277C>A	c.(277-279)Cag>Aag	p.Q93K	C1orf87_ENST00000450089.2_Missense_Mutation_p.Q93K	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	93							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						TCTGATTTCTGGTTGTTCTCT	0.423000													32	117					5.8336e-16	1.02308e-15	0.015359	1	0
CALB2	794	broad.mit.edu	37	16	71417906	71417906	+	Silent	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:71417906T>C	ENST00000302628.4	+	7	588	c.511T>C	c.(511-513)Ttg>Ctg	p.L171L	CALB2_ENST00000349553.5_Silent_p.L171L	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	171	EF-hand 4.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GGATGGCAAATTGGGCCTCTC	0.522000													4	300					0	0	0.009096	0	0
OR10K2	391107	broad.mit.edu	37	1	158390436	158390436	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:158390436G>C	ENST00000314902.2	-	1	220	c.221C>G	c.(220-222)aCc>aGc	p.T74S		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					AATGATGAAGGTGTAGCAAAT	0.473000													46	221					0	0	0.014410	0	0
HCN1	348980	broad.mit.edu	37	5	45267328	45267328	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:45267328C>A	ENST00000303230.4	-	7	1703	c.1646G>T	c.(1645-1647)cGt>cTt	p.R549L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	549						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ACTGGCAGTACGACGTCCTTT	0.413000													16	61					0.000566183	0.000647862	0.004990	1	0
LARS	51520	broad.mit.edu	37	5	145547791	145547791	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:145547791T>C	ENST00000394434.2	-	5	498	c.332A>G	c.(331-333)tAt>tGt	p.Y111C	LARS_ENST00000510191.1_Missense_Mutation_p.Y57C|LARS_ENST00000274562.9_Missense_Mutation_p.Y84C|LARS_ENST00000545646.1_Intron|LARS_ENST00000511505.1_Intron	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	111					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	GGGGCAACCATACAGCTCTAT	0.338000													11	44					0	0	0.010729	0	0
PTPN3	5774	broad.mit.edu	37	9	112168853	112168853	+	Silent	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:112168853A>G	ENST00000412145.1	-	13	3841	c.1288T>C	c.(1288-1290)Tta>Cta	p.L430L	PTPN3_ENST00000446349.1_Silent_p.L385L|PTPN3_ENST00000374541.2_Silent_p.L561L|PTPN3_ENST00000394827.3_Silent_p.L29L|PTPN3_ENST00000262539.3_Silent_p.L407L	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	561					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CCATTGATTAACACGATTTGA	0.547000													4	62					0	0	0.014758	0	0
MYOF	26509	broad.mit.edu	37	10	95152686	95152686	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:95152686C>G	ENST00000371501.4	-	17	1566	c.1444G>C	c.(1444-1446)Gca>Cca	p.A482P	MYOF_ENST00000371502.4_Missense_Mutation_p.A482P|MYOF_ENST00000359263.4_Missense_Mutation_p.A482P|MYOF_ENST00000358334.5_Intron			Q9NZM1	MYOF_HUMAN	myoferlin	482					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GTATATGATGCAGCCCCAGTT	0.323000													41	139					0	0	0.013114	0	0
PALM2	114299	broad.mit.edu	37	9	112642844	112642844	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:112642844G>A	ENST00000448454.2	+	4	146	c.146G>A	c.(145-147)cGg>cAg	p.R49Q	PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.R47Q|PALM2-AKAP2_ENST00000374530.3_Missense_Mutation_p.R47Q|PALM2_ENST00000314527.4_Missense_Mutation_p.R47Q|AKAP2_ENST00000510514.5_Missense_Mutation_p.R47Q|AKAP2_ENST00000555236.1_Missense_Mutation_p.R47Q|PALM2_ENST00000483909.1_Missense_Mutation_p.R47Q|PALM2_ENST00000374531.2_Missense_Mutation_p.R49Q					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						AAAGTGCTTCGGGAGAAATGG	0.532000													5	63					0	0	0.001168	0	0
CFP	5199	broad.mit.edu	37	X	47489073	47489073	+	Splice_Site	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:47489073C>A	ENST00000247153.3	-	3	318	c.76_splice	c.e3-1	p.G26_splice	CFP_ENST00000480317.1_5'UTR|CFP_ENST00000396992.3_Splice_Site_p.G26_splice|CFP_ENST00000377005.2_Splice_Site_p.G26_splice	NM_002621.2	NP_002612.1	P27918	PROP_HUMAN	complement factor properdin	26					complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	18						GGGGTCTGAGCCTGTAACAGG	0.657000													5	2					0.00116845	0.00130284	0.001168	1	0
RANBP3	8498	broad.mit.edu	37	19	5928017	5928017	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:5928017C>A	ENST00000340578.6	-	9	832	c.775G>T	c.(775-777)Gcc>Tcc	p.A259S	RANBP3_ENST00000591092.1_Missense_Mutation_p.A186S|RANBP3_ENST00000541471.1_Missense_Mutation_p.A131S|RANBP3_ENST00000439268.2_Missense_Mutation_p.A254S|RANBP3_ENST00000034275.8_Missense_Mutation_p.A191S	NM_003624.2|NM_007320.2|NM_007322.2	NP_003615.2|NP_015559.2|NP_015561.1	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3	259					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	18						AATACAAAGGCTTGCTGTGTG	0.468000													4	21					0.00116845	0.00130284	0.001168	1	0
AIM1	202	broad.mit.edu	37	6	106967309	106967309	+	Silent	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:106967309G>C	ENST00000369066.3	+	2	1489	c.1002G>C	c.(1000-1002)gtG>gtC	p.V334V		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	334							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGAATGGTGTGCTGGTTAAGG	0.433000													22	31					0	0	0.012319	0	0
DNAH17	8632	broad.mit.edu	37	17	76492015	76492015	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:76492015T>C	ENST00000389840.5	-	38	5927	c.5803A>G	c.(5803-5805)Atg>Gtg	p.M1935V	DNAH17_ENST00000585328.1_Missense_Mutation_p.M1944V|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCAGGGTTCATGGTGATGAAG	0.532000													3	14					0	0	0.004672	0	0
KIFAP3	22920	broad.mit.edu	37	1	170003569	170003569	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:170003569T>C	ENST00000367765.1	-	7	2067	c.566A>G	c.(565-567)cAt>cGt	p.H189R	KIFAP3_ENST00000367767.1_Missense_Mutation_p.H185R|KIFAP3_ENST00000361580.2_Missense_Mutation_p.H229R|KIFAP3_ENST00000538366.1_Missense_Mutation_p.H151R	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	229					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTTTAACTCATGATCAATAAT	0.308000													6	25					0	0	0.001984	0	0
KIAA1549	57670	broad.mit.edu	37	7	138583815	138583815	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:138583815C>T	ENST00000440172.1	-	9	3781	c.3733G>A	c.(3733-3735)Gat>Aat	p.D1245N	KIAA1549_ENST00000422774.1_Missense_Mutation_p.D1245N|KIAA1549_ENST00000242365.4_Missense_Mutation_p.D1195N	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1245						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CCATCTTGATCCTCCACAAAG	0.468000			O	BRAF	pilocytic astrocytoma								99	226					0	0	0.014410	0	0
LPHN3	23284	broad.mit.edu	37	4	62599230	62599230	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:62599230G>T	ENST00000512091.1	+	7	1900	c.1153G>T	c.(1153-1155)Gtg>Ttg	p.V385L	LPHN3_ENST00000506746.1_Missense_Mutation_p.V453L|LPHN3_ENST00000511324.1_Missense_Mutation_p.V453L|LPHN3_ENST00000509896.1_Missense_Mutation_p.V453L|LPHN3_ENST00000514157.1_Missense_Mutation_p.V385L|LPHN3_ENST00000514996.1_Missense_Mutation_p.V385L|LPHN3_ENST00000507164.1_Missense_Mutation_p.V453L|LPHN3_ENST00000508946.1_Missense_Mutation_p.V385L|LPHN3_ENST00000514591.1_Missense_Mutation_p.V385L|LPHN3_ENST00000506720.1_Missense_Mutation_p.V453L|LPHN3_ENST00000508693.1_Missense_Mutation_p.V453L|LPHN3_ENST00000504896.1_Missense_Mutation_p.V385L|LPHN3_ENST00000545650.1_Missense_Mutation_p.V385L|LPHN3_ENST00000506700.1_Missense_Mutation_p.V385L|LPHN3_ENST00000507625.1_Missense_Mutation_p.V453L			Q9HAR2	LPHN3_HUMAN	latrophilin 3	385	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CTATCACGTCGTGAAATATTC	0.393000													9	20					6.40141e-05	7.651e-05	0.010729	1	0
DTNA	1837	broad.mit.edu	37	18	32391955	32391955	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:32391955G>T	ENST00000283365.9	+	7	832	c.481G>T	c.(481-483)Gtg>Ttg	p.V161L	DTNA_ENST00000269190.7_Missense_Mutation_p.V161L|DTNA_ENST00000595022.1_Missense_Mutation_p.V161L|DTNA_ENST00000598774.1_Missense_Mutation_p.V161L|DTNA_ENST00000598142.1_Missense_Mutation_p.V161L|DTNA_ENST00000348997.5_Missense_Mutation_p.V161L|DTNA_ENST00000596745.1_Missense_Mutation_p.V161L|DTNA_ENST00000554864.3_Missense_Mutation_p.V161L|DTNA_ENST00000444659.1_Missense_Mutation_p.V161L|DTNA_ENST00000269191.6_Missense_Mutation_p.V161L|DTNA_ENST00000399097.3_5'UTR|DTNA_ENST00000598334.1_Missense_Mutation_p.V161L|DTNA_ENST00000399121.5_Missense_Mutation_p.V161L|DTNA_ENST00000399113.3_Missense_Mutation_p.V161L|DTNA_ENST00000315456.6_Missense_Mutation_p.V161L|DTNA_ENST00000597599.1_Missense_Mutation_p.V161L	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	161	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						CTCCAGTGGGGTGATGGTTTA	0.383000													12	35					4.36969e-10	6.71816e-10	0.016723	1	0
F8	2157	broad.mit.edu	37	X	154156922	154156922	+	Nonsense_Mutation	SNP	G	G	A	rs137852439		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:154156922G>A	ENST00000360256.4	-	14	5343	c.5143C>T	c.(5143-5145)Cga>Tga	p.R1715*		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1715	F5/8 type A 3.|Plastocyanin-like 5.		R -> G (in HEMA; mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding	p.R1715*(2)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAATAGTGTCGTGTTTTCTTT	0.398000													5	55					0	0	0.014758	0	0
CASQ2	845	broad.mit.edu	37	1	116260499	116260499	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:116260499C>A	ENST00000261448.5	-	8	1039	c.800G>T	c.(799-801)gGg>gTg	p.G267V	CASQ2_ENST00000456138.2_Missense_Mutation_p.G196V	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	267					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		AATGTGGATCCCATTCAAATC	0.463000													16	88					6.94344e-10	1.05359e-09	0.006122	1	0
LOC728715	728715	broad.mit.edu	37	12	9716829	9716829	+	RNA	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:9716829A>G	ENST00000520314.1	+	0	4024																											GGCTATAATCATGCAATTCTA	0.428000													6	14					0	0	0.006214	0	0
ULK4	54986	broad.mit.edu	37	3	41504623	41504623	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:41504623G>A	ENST00000301831.4	-	33	3810	c.3348C>T	c.(3346-3348)caC>caT	p.H1116H		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	1116							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TCAGCATGCTGTGCAAAATAT	0.483000													8	88					0	0	0.003080	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018085	161018085	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:161018085C>A	ENST00000368013.3	-	12	3046	c.2726G>T	c.(2725-2727)tGt>tTt	p.C909F	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.C732F|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.C698F	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	909					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGGGCATAGACAGCCGTCTGG	0.617000													20	24					3.28513e-13	5.51206e-13	0.021523	1	0
RTL1	388015	broad.mit.edu	37	14	101349397	101349397	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:101349397C>T	ENST00000534062.1	-	1	1787	c.1729G>A	c.(1729-1731)Gac>Aac	p.D577N	MIR127_ENST00000384876.1_RNA	NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	577										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						CTTGGCTGGTCGGAAGTCTCA	0.557000													8	13					0	0	0.006214	0	0
MYH6	4624	broad.mit.edu	37	14	23853924	23853924	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:23853924G>T	ENST00000405093.3	-	36	5362	c.5292C>A	c.(5290-5292)gcC>gcA	p.A1764A	MYH6_ENST00000356287.3_Silent_p.A1764A	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1764					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCATCATGGCGGCCTGTGTGC	0.602000													13	36					3.51602e-12	5.65479e-12	0.008871	1	0
PCLO	27445	broad.mit.edu	37	7	82764767	82764767	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:82764767G>A	ENST00000423517.2	-	3	2436	c.2099C>T	c.(2098-2100)cCt>cTt	p.P700L	PCLO_ENST00000333891.8_Missense_Mutation_p.P700L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	646	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGCTTTTTAGGCTCAGGTGC	0.537000													20	58					0	0	0.008871	0	0
NEK5	341676	broad.mit.edu	37	13	52667205	52667205	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:52667205G>T	ENST00000355568.4	-	13	1332	c.1193C>A	c.(1192-1194)cCa>cAa	p.P398Q		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	398							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ACTTGGGGATGGACCATGCCT	0.373000													12	23					5.50884e-06	6.89098e-06	0.013537	1	0
NEUROD2	4761	broad.mit.edu	37	17	37762594	37762594	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:37762594C>G	ENST00000302584.4	-	2	479	c.259G>C	c.(259-261)Gag>Cag	p.E87Q		NM_006160.3	NP_006151.3	Q15784	NDF2_HUMAN	neuronal differentiation 2	87	Poly-Glu.				cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)	8	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			tcctcctcctcttcctcctcc	0.672000													3	28					0	0	0.009096	0	0
CRTAM	56253	broad.mit.edu	37	11	122722484	122722484	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:122722484G>T	ENST00000227348.4	+	3	324	c.277G>T	c.(277-279)Gaa>Taa	p.E93*		NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	93	Ig-like V-type.				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		CCTGCAAGATGAAGGCGTGTA	0.458000													12	60					2.27111e-07	3.04853e-07	0.013537	1	0
DLC1	10395	broad.mit.edu	37	8	12943415	12943415	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:12943415T>A	ENST00000276297.4	-	18	4901	c.4492A>T	c.(4492-4494)Aaa>Taa	p.K1498*	DLC1_ENST00000512044.2_Nonsense_Mutation_p.K1095*|DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000520226.1_Nonsense_Mutation_p.K987*|DLC1_ENST00000358919.2_Nonsense_Mutation_p.K1061*	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1498	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCAAAAGATTTTGTGTACCAT	0.378000													13	27					0	0	0.020292	0	0
FAM83D	81610	broad.mit.edu	37	20	37580763	37580763	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:37580763C>A	ENST00000217429.4	+	4	1489	c.1448C>A	c.(1447-1449)cCt>cAt	p.P483H		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	453	Ser-rich.				cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				ATTCTCTTTCCTCGAGGAACT	0.473000													8	51					0.00448238	0.00487337	0.004482	1	0
TRPS1	7227	broad.mit.edu	37	8	116427152	116427152	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:116427152C>A	ENST00000395715.3	-	7	3561	c.2984G>T	c.(2983-2985)aGg>aTg	p.R995M	TRPS1_ENST00000220888.5_Missense_Mutation_p.R982M|TRPS1_ENST00000520276.1_Missense_Mutation_p.R986M|TRPS1_ENST00000519076.1_Missense_Mutation_p.R736M	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	982	Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTCTGACCTCCTCTCTAACGG	0.488000									Langer-Giedion syndrome				23	77					1.10513e-12	1.83663e-12	0.014323	1	0
ZNF695	57116	broad.mit.edu	37	1	247150661	247150661	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:247150661C>A	ENST00000339986.7	-	4	1303	c.1156G>T	c.(1156-1158)Ggc>Tgc	p.G386C	ZNF695_ENST00000498046.2_Intron|ZNF695_ENST00000487338.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	386					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAAGCTTTGCCACATTCCTCA	0.413000													16	61					1.33834e-09	2.01327e-09	0.007413	1	0
AKAP13	11214	broad.mit.edu	37	15	86129055	86129055	+	Splice_Site	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:86129055G>C	ENST00000394518.2	+	8	4256		c.e8+1		AKAP13_ENST00000361243.2_Splice_Site	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GACCCAGGCGGTAAGTGGCAT	0.428000													13	78					0	0	0.003163	0	0
BRCA2	675	broad.mit.edu	37	13	32912687	32912687	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:32912687T>C	ENST00000544455.1	+	11	4422	c.4195T>C	c.(4195-4197)Tgt>Cgt	p.C1399R	BRCA2_ENST00000380152.3_Missense_Mutation_p.C1399R	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1399					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TCAAGAAGCATGTCATGGTAA	0.328000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			3	19					0	0	0.004672	0	0
SVOPL	136306	broad.mit.edu	37	7	138333867	138333867	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:138333867C>A	ENST00000421622.1	-	4	398	c.190G>T	c.(190-192)Ggc>Tgc	p.G64C	SVOPL_ENST00000288513.5_Missense_Mutation_p.G32C|SVOPL_ENST00000419765.3_Missense_Mutation_p.G184C|SVOPL_ENST00000436657.1_Missense_Mutation_p.G32C			Q8N434	SVOPL_HUMAN	SVOP-like	184						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						AGCAGGGAGCCCGCAAGCCAG	0.473000													9	18					3.41278e-10	5.29361e-10	0.004990	1	0
MYH4	4622	broad.mit.edu	37	17	10350502	10350502	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:10350502C>A	ENST00000255381.2	-	35	5107	c.4997G>T	c.(4996-4998)aGa>aTa	p.R1666I	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1666					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						ATCTTGGCCTCTGATGGCATC	0.468000													9	33					1.12685e-05	1.39458e-05	0.004482	1	0
BSND	7809	broad.mit.edu	37	1	55474144	55474144	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:55474144G>T	ENST00000371265.4	+	4	1060	c.806G>T	c.(805-807)cGg>cTg	p.R269L		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	269						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						AACTGGCAGCGGTACCCAAGG	0.577000													10	16					7.48243e-07	9.70769e-07	0.006214	1	0
ZNF713	349075	broad.mit.edu	37	7	56006849	56006849	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:56006849A>G	ENST00000429591.2	+	4	481	c.443A>G	c.(442-444)aAg>aGg	p.K148R	MRPS17_ENST00000426595.1_Intron	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAAAACCACAAGAGATATTTA	0.403000													12	56					0	0	0.010729	0	0
PYGB	5834	broad.mit.edu	37	20	25276279	25276279	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:25276279C>T	ENST00000216962.4	+	19	2462	c.2352C>T	c.(2350-2352)tgC>tgT	p.C784C	PYGB_ENST00000471359.1_3'UTR|ABHD12_ENST00000376542.3_Intron	NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	784					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	ACATGCAGTGCCAGGCACAGG	0.602000													3	18					0	0	0.004672	0	0
CSMD2	114784	broad.mit.edu	37	1	34088983	34088983	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:34088983C>T	ENST00000373381.4	-	36	5885	c.5709G>A	c.(5707-5709)ctG>ctA	p.L1903L	CSMD2_ENST00000373388.2_Silent_p.L2L|CSMD2_ENST00000373380.1_Silent_p.L776L|CSMD2_ENST00000373377.1_Silent_p.L2L	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1863	CUB 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGAAACTCCCCAGCATGGTTA	0.433000													14	34					0	0	0.004007	0	0
DCDC1	341019	broad.mit.edu	37	11	30926637	30926637	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:30926637C>A	ENST00000597505.1	-	29	4178	c.4179G>T	c.(4177-4179)aaG>aaT	p.K1393N	DCDC1_ENST00000339794.5_Missense_Mutation_p.K472N|DCDC1_ENST00000406071.2_Missense_Mutation_p.K128N			P59894	DCDC1_HUMAN	doublecortin domain containing 1	155					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GCGTGCAGGTCTTCATCCGTA	0.408000													7	9					1.06961e-07	1.48723e-07	0.003080	1	0
BMS1	9790	broad.mit.edu	37	10	43292056	43292056	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:43292056G>T	ENST00000374518.4	+	10	1427	c.1364G>T	c.(1363-1365)gGg>gTg	p.G455V		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	455					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity	p.G455V(1)		NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GAAGATGACGGGTTGGAAAAC	0.438000													13	94					0.000219431	0.000254424	0.020292	1	0
GCC1	79571	broad.mit.edu	37	7	127222355	127222355	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:127222355C>A	ENST00000321407.2	-	2	2465	c.2041G>T	c.(2041-2043)Gtg>Ttg	p.V681L		NM_024523.5	NP_078799.2	Q96CN9	GCC1_HUMAN	GRIP and coiled-coil domain containing 1	681						Golgi membrane|plasma membrane	protein binding			breast(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						AGCTGATGCACCTCGACCTCC	0.587000													8	33					4.7546e-09	7.00151e-09	0.004007	1	0
LPPR4	9890	broad.mit.edu	37	1	99771331	99771331	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:99771331G>T	ENST00000370185.3	+	7	1554	c.1057G>T	c.(1057-1059)Gat>Tat	p.D353Y	LPPR4_ENST00000370184.1_Missense_Mutation_p.D195Y|LPPR4_ENST00000457765.1_Missense_Mutation_p.D295Y	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		353							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCTCAATCAAGATCCCAACCG	0.478000													5	102					8.12818e-05	9.58357e-05	0.001984	1	0
COL5A3	50509	broad.mit.edu	37	19	10106290	10106290	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:10106290G>A	ENST00000264828.3	-	16	1622	c.1537C>T	c.(1537-1539)Ccc>Tcc	p.P513S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	513	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGGCCTCGGGGACCCTAGAAG	0.493000													8	41					0	0	0.008291	0	0
TNNI3	7137	broad.mit.edu	37	19	55665443	55665443	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:55665443G>T	ENST00000344887.5	-	7	646	c.504C>A	c.(502-504)gaC>gaA	p.D168E	TNNI3_ENST00000588882.1_Missense_Mutation_p.D143E	NM_000363.4	NP_000354.4	P19429	TNNI3_HUMAN	troponin I type 3 (cardiac)	168					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGGCCCGCAGGTCCAGGGACT	0.627000													7	37					8.12818e-05	9.58357e-05	0.001984	1	0
PCDHB8	56128	broad.mit.edu	37	5	140558412	140558412	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:140558412C>A	ENST00000239444.2	+	1	1042	c.797C>A	c.(796-798)tCt>tAt	p.S266Y		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		266	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGAAGGTCTCTGCCACGGAT	0.438000													19	89					2.32416e-17	4.11742e-17	0.014323	1	0
PLK1	5347	broad.mit.edu	37	16	23700048	23700048	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:23700048T>G	ENST00000300093.4	+	7	1363	c.1252T>G	c.(1252-1254)Tcg>Gcg	p.S418A		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	418	POLO box 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		GGTGGACTATTCGGACAAGTA	0.527000													4	52					0	0	0.014758	0	0
PCDH17	27253	broad.mit.edu	37	13	58207420	58207420	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:58207420C>T	ENST00000377918.3	+	1	766	c.740C>T	c.(739-741)tCc>tTc	p.S247F		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	247	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GAGGCGCCATCCTACTTGGTG	0.597000													13	26					0	0	0.016723	0	0
CCNYL1	151195	broad.mit.edu	37	2	208611892	208611892	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:208611892A>T	ENST00000295414.3	+	8	972	c.761A>T	c.(760-762)aAt>aTt	p.N254I	CCNYL1_ENST00000392209.3_Missense_Mutation_p.N184I|CCNYL1_ENST00000339882.5_Missense_Mutation_p.N203I			Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1	254	Cyclin N-terminal.				regulation of cyclin-dependent protein kinase activity		protein kinase binding			endometrium(1)|large_intestine(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)		GCTGTATGGAATGTGGACTAC	0.433000													17	42					0	0	0.006122	0	0
GPR128	84873	broad.mit.edu	37	3	100365438	100365438	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:100365438A>C	ENST00000273352.3	+	10	1404	c.1136A>C	c.(1135-1137)tAt>tCt	p.Y379S	GPR128_ENST00000475887.1_Missense_Mutation_p.Y84S	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	379					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						TTTCAACTCTATTCCTATGCC	0.373000													7	22					0	0	0.004482	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237858	140237858	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:140237858C>T	ENST00000307360.5	+	1	2225	c.2225C>T	c.(2224-2226)gCg>gTg	p.A742V	PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTCTAGCGCGGTGGGGAGC	0.682000													5	20					0	0	0.014758	0	0
ZNF98	148198	broad.mit.edu	37	19	22574940	22574940	+	Missense_Mutation	SNP	G	G	T	rs74170714		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:22574940G>T	ENST00000357774.5	-	4	1218	c.1097C>A	c.(1096-1098)aCt>aAt	p.T366N		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CTTATGTGTAGTAAGGTGGGA	0.383000													3	12					0.00116845	0.00130284	0.001168	1	0
DHX40	79665	broad.mit.edu	37	17	57647932	57647932	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:57647932A>G	ENST00000451169.2	+	3	396	c.37A>G	c.(37-39)Ata>Gta	p.I13V	DHX40_ENST00000425628.3_Intron|DHX40_ENST00000251241.4_Missense_Mutation_p.I112V			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	112							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AGTAGCTGCTATATCAGTTGC	0.373000													9	67					0	0	0.010729	0	0
DSP	1832	broad.mit.edu	37	6	7578716	7578716	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:7578716G>T	ENST00000379802.3	+	22	3346	c.3005G>T	c.(3004-3006)cGg>cTg	p.R1002L	DSP_ENST00000418664.2_Missense_Mutation_p.R1002L	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1002	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GTTCATGCTCGGTACATTGAA	0.343000													20	35					1.28384e-07	1.7571e-07	0.012319	1	0
NRSN1	140767	broad.mit.edu	37	6	24145856	24145856	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:24145856C>T	ENST00000378491.4	+	4	571	c.270C>T	c.(268-270)atC>atT	p.I90I		NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	90					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						CCCCCAAAATCGAAGCATTTG	0.488000													28	62					0	0	0.010818	0	0
CAMKV	79012	broad.mit.edu	37	3	49897637	49897637	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:49897637C>A	ENST00000477224.1	-	10	1387	c.909G>T	c.(907-909)caG>caT	p.Q303H	CAMKV_ENST00000463537.1_Missense_Mutation_p.Q303H|CAMKV_ENST00000296471.7_Missense_Mutation_p.Q275H|CAMKV_ENST00000467248.1_Missense_Mutation_p.Q228H|CAMKV_ENST00000466940.1_Missense_Mutation_p.Q260H|CAMKV_ENST00000488336.1_Missense_Mutation_p.Q303H			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	303						cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCTTTTCAATCTGGGCACAGA	0.478000													7	22					2.0095e-06	2.55024e-06	0.001984	1	0
LRRC6	23639	broad.mit.edu	37	8	133596010	133596010	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:133596010G>A	ENST00000519595.1	-	11	1255	c.1157C>T	c.(1156-1158)aCa>aTa	p.T386I	LRRC6_ENST00000250173.1_Missense_Mutation_p.T386I|LRRC6_ENST00000518642.1_Missense_Mutation_p.T383I			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	386	CS.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTGACCACCTGTGATTACTTC	0.378000													12	46					0	0	0.013537	0	0
CECR2	27443	broad.mit.edu	37	22	18022674	18022674	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr22:18022674G>C	ENST00000262608.8	+	15	2779	c.2779G>C	c.(2779-2781)Gag>Cag	p.E927Q	CECR2_ENST00000400585.2_Missense_Mutation_p.E785Q|CECR2_ENST00000400573.4_Missense_Mutation_p.E926Q	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	968					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		TGAAGCACAAGAGCCTGAGAA	0.493000													19	16					0	0	0.021523	0	0
SPTA1	6708	broad.mit.edu	37	1	158641242	158641242	+	Splice_Site	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:158641242G>T	ENST00000368148.3	-	12	1670	c.1488_splice	c.e12-1	p.A497_splice	SPTA1_ENST00000368147.3_Splice_Site_p.A497_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	497					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCCAGGAAGGCCTGTAGAAG	0.493000													22	21					9.95505e-16	1.72851e-15	0.014323	1	0
ZNF568	374900	broad.mit.edu	37	19	37441034	37441034	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:37441034A>T	ENST00000415168.1	+	5	1163	c.787A>T	c.(787-789)Att>Ttt	p.I263F	ZNF568_ENST00000333987.7_Missense_Mutation_p.I327F|ZNF568_ENST00000427117.1_Intron|ZNF568_ENST00000455427.2_Intron	NM_001204837.1	NP_001191766.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	327					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATGAGCGAATTCACACTGG	0.398000													6	27					0	0	0.001984	0	0
PARD3B	117583	broad.mit.edu	37	2	205989156	205989156	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:205989156A>G	ENST00000406610.2	+	9	1478	c.1271A>G	c.(1270-1272)gAt>gGt	p.D424G	PARD3B_ENST00000351153.1_Missense_Mutation_p.D424G|PARD3B_ENST00000358768.2_Missense_Mutation_p.D424G|PARD3B_ENST00000349953.3_Missense_Mutation_p.D424G|PARD3B_ENST00000462231.1_Missense_Mutation_p.D424G	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	424	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GCAATAAAAGATGGCCGCCTA	0.378000													13	38					0	0	0.020292	0	0
SYNE1	23345	broad.mit.edu	37	6	152712447	152712447	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:152712447T>G	ENST00000367255.5	-	52	8570	c.7969A>C	c.(7969-7971)Aaa>Caa	p.K2657Q	SYNE1_ENST00000423061.1_Missense_Mutation_p.K2664Q|SYNE1_ENST00000341594.5_Missense_Mutation_p.K2696Q|SYNE1_ENST00000448038.1_Missense_Mutation_p.K2664Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.K2657Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2657					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGGTGTCTTTGCTCCCAAGA	0.517000										HNSCC(10;0.0054)			7	14					0	0	0.003080	0	0
PHLDB1	23187	broad.mit.edu	37	11	118498238	118498238	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:118498238G>T	ENST00000361417.2	+	7	1110	c.699G>T	c.(697-699)ctG>ctT	p.L233L	PHLDB1_ENST00000356063.5_Silent_p.L233L	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	233										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GCTACCTGCTGTCTCCCCCAA	0.607000													27	82					2.70662e-09	4.0368e-09	0.009535	1	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100451511	100451511	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:100451511C>A	ENST00000279907.7	-	15	3474	c.3262G>T	c.(3262-3264)Gaa>Taa	p.E1088*	UHRF1BP1L_ENST00000545232.2_Nonsense_Mutation_p.E738*	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1088										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						GGGCAACGTTCCTTAGGCTTT	0.313000													4	6					0.00198382	0.00217721	0.001984	1	0
SLC45A2	51151	broad.mit.edu	37	5	33947341	33947341	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:33947341C>A	ENST00000382102.3	-	6	1352	c.1295G>T	c.(1294-1296)gGt>gTt	p.G432V	SLC45A2_ENST00000296589.4_Missense_Mutation_p.G432V|SLC45A2_ENST00000342059.3_Missense_Mutation_p.G373V	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	432					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						GGACATTACACCAAACAGGCT	0.517000													12	227					2.27111e-07	3.04853e-07	0.013537	1	0
NSUN2	54888	broad.mit.edu	37	5	6609940	6609940	+	Splice_Site	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:6609940T>A	ENST00000264670.6	-	12	1633	c.1323_splice	c.e12+1	p.K441_splice	NSUN2_ENST00000506139.1_Splice_Site_p.K406_splice|NSUN2_ENST00000539938.1_Splice_Site_p.K205_splice	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	441						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						AAAACTCACCTTTGGCTGACG	0.368000													8	47					0	0	0.004482	0	0
PLEC	5339	broad.mit.edu	37	8	144993934	144993934	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:144993934T>G	ENST00000322810.4	-	32	10635	c.10466A>C	c.(10465-10467)cAg>cCg	p.Q3489P	PLEC_ENST00000345136.3_Missense_Mutation_p.Q3352P|PLEC_ENST00000398774.2_Missense_Mutation_p.Q3320P|PLEC_ENST00000357649.2_Missense_Mutation_p.Q3356P|PLEC_ENST00000436759.2_Missense_Mutation_p.Q3379P|PLEC_ENST00000527096.1_Missense_Mutation_p.Q3375P|PLEC_ENST00000354958.2_Missense_Mutation_p.Q3330P|PLEC_ENST00000354589.3_Missense_Mutation_p.Q3352P|PLEC_ENST00000356346.3_Missense_Mutation_p.Q3338P	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3489	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCACTGCCCTGCAGCAGCGT	0.652000													6	12					0	0	0.013537	0	0
FMN2	56776	broad.mit.edu	37	1	240341343	240341343	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:240341343A>T	ENST00000319653.9	+	3	2135	c.1905A>T	c.(1903-1905)gaA>gaT	p.E635D	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	635					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCGATGAGGAACACAGGCTCG	0.468000													4	50					0	0	0.001168	0	0
C1orf162	128346	broad.mit.edu	37	1	112020713	112020713	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:112020713A>T	ENST00000343534.5	+	6	686	c.436A>T	c.(436-438)Att>Ttt	p.I146F	C1orf162_ENST00000369718.3_Missense_Mutation_p.I121F|C1orf162_ENST00000464591.1_3'UTR	NM_174896.2	NP_777556.1	Q8NEQ5	CA162_HUMAN	chromosome 1 open reading frame 162	146						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		CTTTGACCCCATTGTCTATGC	0.423000													16	63					0	0	0.006122	0	0
GABRA2	2555	broad.mit.edu	37	4	46307650	46307650	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:46307650G>T	ENST00000510861.1	-	7	811	c.638C>A	c.(637-639)tCt>tAt	p.S213Y	GABRA2_ENST00000515082.1_Missense_Mutation_p.S213Y|GABRA2_ENST00000381620.4_Missense_Mutation_p.S213Y|GABRA2_ENST00000514090.1_Missense_Mutation_p.S213Y|GABRA2_ENST00000507069.1_Missense_Mutation_p.S213Y|GABRA2_ENST00000356504.1_Missense_Mutation_p.S213Y|GABRA2_ENST00000540012.1_Missense_Mutation_p.S158Y			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	213					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATTTAACCTAGAGCCATCAGG	0.368000													10	51					7.48243e-07	9.70769e-07	0.006214	1	0
TCHH	7062	broad.mit.edu	37	1	152083862	152083862	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:152083862C>A	ENST00000368804.1	-	2	1830	c.1831G>T	c.(1831-1833)Gag>Tag	p.E611*		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	611	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCCTGCTCGAGTCTCTCC	0.682000													20	28					8.73648e-17	1.53991e-16	0.019004	1	0
ZNRF4	148066	broad.mit.edu	37	19	5456479	5456479	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:5456479C>A	ENST00000222033.4	+	1	1054	c.977C>A	c.(976-978)cCc>cAc	p.P326H		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	326						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		AAGATCCTGCCCTGCTCCCAC	0.622000													7	47					0.000157383	0.000183089	0.003080	1	0
NGEF	25791	broad.mit.edu	37	2	233785158	233785158	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:233785158C>A	ENST00000264051.3	-	5	942	c.664G>T	c.(664-666)Gag>Tag	p.E222*	NGEF_ENST00000409079.1_Nonsense_Mutation_p.E130*|NGEF_ENST00000373552.4_Nonsense_Mutation_p.E130*	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	222	Poly-Glu.|Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		tcctcctcctcctcttcttct	0.572000													13	23					0.00010058	0.000117793	0.013537	1	0
VIT	5212	broad.mit.edu	37	2	36982177	36982177	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:36982177G>T	ENST00000379242.3	+	5	691	c.389G>T	c.(388-390)aGa>aTa	p.R130I	VIT_ENST00000401530.1_Missense_Mutation_p.R130I|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000457137.2_Missense_Mutation_p.R130I|VIT_ENST00000379241.3_Missense_Mutation_p.R130I|VIT_ENST00000404084.1_Missense_Mutation_p.R108I|VIT_ENST00000389975.3_Missense_Mutation_p.R130I	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	130	LCCL.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				CCACGATGGAGAGAATCCTTT	0.438000													15	52					3.51602e-12	5.65479e-12	0.008871	1	0
FBN1	2200	broad.mit.edu	37	15	48726890	48726890	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:48726890C>A	ENST00000316623.5	-	54	6972	c.6517G>T	c.(6517-6519)Ggc>Tgc	p.G2173C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2173	EGF-like 37; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CAAGGATTGCCAACAGAACAT	0.408000													8	36					7.48243e-07	9.70769e-07	0.006214	1	0
ASTN2	23245	broad.mit.edu	37	9	119737556	119737556	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:119737556T>C	ENST00000313400.4	-	10	1920	c.1820A>G	c.(1819-1821)gAg>gGg	p.E607G	ASTN2_ENST00000361209.2_Missense_Mutation_p.E556G|ASTN2_ENST00000373996.3_Missense_Mutation_p.E603G|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	607						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GATGGACAGCTCCACAGGCGG	0.547000													11	56					0	0	0.013537	0	0
EPHA3	2042	broad.mit.edu	37	3	89499516	89499516	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:89499516G>T	ENST00000336596.2	+	15	2911	c.2686G>T	c.(2686-2688)Gca>Tca	p.A896S	EPHA3_ENST00000494014.1_Missense_Mutation_p.A896S	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	896						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CAGTGCAGCCGCAAGGTGACA	0.428000										TSP Lung(6;0.00050)			22	20					2.98393e-07	3.99001e-07	0.016522	1	0
SV2C	22987	broad.mit.edu	37	5	75427579	75427579	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:75427579G>C	ENST00000502798.2	+	2	446	c.4G>C	c.(4-6)Gaa>Caa	p.E2Q	SV2C_ENST00000322285.7_Missense_Mutation_p.E2Q	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	2	Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		AGATAAGATGGAAGACTCTTA	0.443000													21	63					0	0	0.016522	0	0
NXPE1	120400	broad.mit.edu	37	11	114392743	114392743	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:114392743G>T	ENST00000536271.1	-	4	1982	c.739C>A	c.(739-741)Cct>Act	p.P247T	NXPE1_ENST00000251921.2_Missense_Mutation_p.P389T|NXPE1_ENST00000424269.1_Missense_Mutation_p.P531T					neurexophilin and PC-esterase domain family, member 1																		ACATGATCAGGTGGGTGGATA	0.383000													19	103					1.55795e-14	2.65231e-14	0.012319	1	0
DENND5B	160518	broad.mit.edu	37	12	31632547	31632547	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:31632547T>C	ENST00000389082.5	-	3	1144	c.880A>G	c.(880-882)Atg>Gtg	p.M294V	DENND5B_ENST00000536562.1_Missense_Mutation_p.M329V|DENND5B_ENST00000545147.1_Intron|DENND5B_ENST00000354285.4_Missense_Mutation_p.M316V|DENND5B_ENST00000306833.6_Missense_Mutation_p.M329V	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	294	DENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGGATTTGCATCTCTAAAAGA	0.453000													4	14					0	0	0.014758	0	0
CTC1	80169	broad.mit.edu	37	17	8139421	8139421	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:8139421C>T	ENST00000315684.8	-	6	1039	c.1032G>A	c.(1030-1032)aaG>aaA	p.K344K		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	344					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						TTTCTGGATCCTTCTTGTCCT	0.532000													5	147					0	0	0.001168	0	0
APOB	338	broad.mit.edu	37	2	21236288	21236288	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:21236288G>T	ENST00000233242.1	-	25	4087	c.3960C>A	c.(3958-3960)gcC>gcA	p.A1320A		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1320					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGAAGTGGAGGGCTGGTGTCC	0.448000													30	89					1.55811e-20	2.81752e-20	0.008361	1	0
LRP1B	53353	broad.mit.edu	37	2	141027816	141027816	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:141027816C>T	ENST00000389484.3	-	86	14213	c.13242G>A	c.(13240-13242)gtG>gtA	p.V4414V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4414	EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTCACAGACACACAGGTACAT	0.413000										TSP Lung(27;0.18)			6	40					0	0	0.001168	0	0
DNM1P46	196968	broad.mit.edu	37	15	100331113	100331113	+	RNA	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:100331113G>T	ENST00000341853.1	-	0	3078					NR_003260.1																						TGCATGGACAGCTTTCCTTGT	0.552000													5	23					0.014758	0.0156551	0.014758	1	0
GGCX	2677	broad.mit.edu	37	2	85783362	85783362	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:85783362A>C	ENST00000233838.3	-	5	641	c.561T>G	c.(559-561)aaT>aaG	p.N187K	GGCX_ENST00000430215.3_Missense_Mutation_p.N130K	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	187					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TCCTATGGGCATTCAGCAGAC	0.527000													8	29					0	0	0.003080	0	0
OR4S2	219431	broad.mit.edu	37	11	55419256	55419256	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:55419256A>G	ENST00000312422.2	+	1	877	c.877A>G	c.(877-879)Aag>Gag	p.K293E		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TGCAGAAGTAAAGAATGCAAT	0.358000													17	82					0	0	0.010504	0	0
NIN	51199	broad.mit.edu	37	14	51243814	51243814	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:51243814C>A	ENST00000245441.5	-	7	709	c.519G>T	c.(517-519)caG>caT	p.Q173H	NIN_ENST00000389868.3_Missense_Mutation_p.Q173H|NIN_ENST00000530997.2_Missense_Mutation_p.Q173H|NIN_ENST00000324330.9_Missense_Mutation_p.Q173H|NIN_ENST00000453196.1_Missense_Mutation_p.Q173H|NIN_ENST00000382041.3_Missense_Mutation_p.Q173H|NIN_ENST00000382043.4_Missense_Mutation_p.Q173H	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	173					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					AAGATCCACTCTGTGAAGCAT	0.478000			T	PDGFRB	MPD								12	46					1.5739e-10	2.45219e-10	0.004007	1	0
OR13G1	441933	broad.mit.edu	37	1	247836151	247836151	+	Missense_Mutation	SNP	C	C	G	rs141463427		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:247836151C>G	ENST00000359688.2	-	1	214	c.193G>C	c.(193-195)Gtt>Ctt	p.V65L	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGTCCACAACAGCCAGTGTC	0.448000													16	24					0	0	0.004990	0	0
IBTK	25998	broad.mit.edu	37	6	82911190	82911190	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:82911190A>T	ENST00000306270.7	-	19	3288	c.2739T>A	c.(2737-2739)gaT>gaA	p.D913E	IBTK_ENST00000503631.1_Missense_Mutation_p.D712E|IBTK_ENST00000510291.1_Missense_Mutation_p.D913E	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	913					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CGCTTAAAACATCAAGAGACC	0.318000													4	11					0	0	0.001168	0	0
IL12RB1	3594	broad.mit.edu	37	19	18179326	18179326	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:18179326G>T	ENST00000600835.1	-	12	1503	c.1200C>A	c.(1198-1200)agC>agA	p.S400R	IL12RB1_ENST00000593993.1_Missense_Mutation_p.S400R|IL12RB1_ENST00000430026.2_Missense_Mutation_p.S400R			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	400	Fibronectin type-III 4.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CTCGACTCCAGCTGTAGGTTG	0.552000													25	65					7.01153e-11	1.10226e-10	0.007291	1	0
TENM3	55714	broad.mit.edu	37	4	183522271	183522271	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:183522271C>T	ENST00000511685.1	+	4	829	c.706C>T	c.(706-708)Cag>Tag	p.Q236*	TENM3_ENST00000406950.2_Nonsense_Mutation_p.Q236*					teneurin transmembrane protein 3																		CGTCCAGCTGCAGGACAGCTG	0.532000													30	35					0	0	0.010771	0	0
OFCC1	266553	broad.mit.edu	37	6	9897138	9897138	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:9897138G>T	ENST00000316020.6	-	7	809	c.810C>A	c.(808-810)taC>taA	p.Y270*	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				GCTCTCTATAGTACCTCCTGC	0.418000													8	29					6.5536e-12	1.04918e-11	0.003080	1	0
IRGQ	126298	broad.mit.edu	37	19	44096260	44096260	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:44096260G>A	ENST00000422989.1	-	3	1945	c.1790C>T	c.(1789-1791)gCt>gTt	p.A597V	IRGQ_ENST00000602269.1_Missense_Mutation_p.A597V|L34079.2_ENST00000594374.1_Intron|IRGQ_ENST00000601520.1_Intron	NM_001007561.2	NP_001007562.1	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	597	Ala-rich.						protein binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(3)	18		Prostate(69;0.0199)				GACGCCGTGAGCCGCTCGGTA	0.711000													6	3					0	0	0.004482	0	0
SRCAP	10847	broad.mit.edu	37	16	30733964	30733964	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:30733964G>T	ENST00000262518.4	+	23	4172	c.3787G>T	c.(3787-3789)Gtg>Ttg	p.V1263L	SRCAP_ENST00000344771.4_Intron|SRCAP_ENST00000395059.2_Intron	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1263	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CATCCAGGCCGTGGCCCCGAC	0.647000													7	350					0.00307968	0.00335877	0.003080	1	0
LTBP1	4052	broad.mit.edu	37	2	33622279	33622279	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:33622279G>T	ENST00000404816.2	+	33	5267	c.4914G>T	c.(4912-4914)agG>agT	p.R1638S	LTBP1_ENST00000354476.3_Missense_Mutation_p.R1639S|LTBP1_ENST00000418533.2_Missense_Mutation_p.R1270S|LTBP1_ENST00000402934.1_Missense_Mutation_p.R1257S|LTBP1_ENST00000272273.5_Missense_Mutation_p.R536S|LTBP1_ENST00000407925.1_Missense_Mutation_p.R1312S|LTBP1_ENST00000404525.1_Missense_Mutation_p.R1259S|LTBP1_ENST00000390003.4_Missense_Mutation_p.R1313S			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1638	EGF-like 17.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GCTGTGTGAGGGTCCAGGAAG	0.473000													18	29					3.51602e-12	5.65479e-12	0.008871	1	0
PITPNM3	83394	broad.mit.edu	37	17	6367063	6367063	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:6367063C>A	ENST00000262483.8	-	17	2382	c.2295G>T	c.(2293-2295)gtG>gtT	p.V765V	ACKR6_ENST00000576664.1_5'UTR|ACKR6_ENST00000421306.3_Silent_p.V729V	NM_031220.3	NP_112497.2																					GGACAACATCCACTGCACCCG	0.592000													3	14					0.00909568	0.00970762	0.009096	1	0
TNS3	64759	broad.mit.edu	37	7	47384613	47384613	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:47384613C>G	ENST00000398879.1	-	19	2841	c.2475G>C	c.(2473-2475)caG>caC	p.Q825H	TNS3_ENST00000355730.3_Missense_Mutation_p.Q585H|TNS3_ENST00000311160.9_Missense_Mutation_p.Q825H			Q68CZ2	TENS3_HUMAN	tensin 3	825						focal adhesion	protein binding	p.Q825H(1)		NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TATCGAGGTCCTGGGGATAGC	0.488000													12	32					0	0	0.010729	0	0
KIAA1958	158405	broad.mit.edu	37	9	115337206	115337206	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:115337206G>A	ENST00000337530.6	+	2	1142	c.846G>A	c.(844-846)caG>caA	p.Q282Q	KIAA1958_ENST00000374244.3_Silent_p.Q282Q|KIAA1958_ENST00000536272.1_Silent_p.Q282Q	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	282										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						CAATTGTCCAGAAGACTGCTA	0.542000													38	288					0	0	0.006999	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018084	161018084	+	Silent	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:161018084A>G	ENST00000368013.3	-	12	3047	c.2727T>C	c.(2725-2727)tgT>tgC	p.C909C	ARHGAP30_ENST00000368015.1_Silent_p.C732C|ARHGAP30_ENST00000368016.3_Silent_p.C698C	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	909					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGGGGCATAGACAGCCGTCTG	0.617000													20	24					0	0	0.018920	0	0
PITPNM3	83394	broad.mit.edu	37	17	6367062	6367062	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:6367062C>A	ENST00000262483.8	-	17	2383	c.2296G>T	c.(2296-2298)Gat>Tat	p.D766Y	ACKR6_ENST00000576664.1_5'UTR|ACKR6_ENST00000421306.3_Missense_Mutation_p.D730Y	NM_031220.3	NP_112497.2																					CGGACAACATCCACTGCACCC	0.592000													3	16					0.00909568	0.00970762	0.009096	1	0
KLHL9	55958	broad.mit.edu	37	9	21334680	21334680	+	Missense_Mutation	SNP	T	T	C	rs140581276		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:21334680T>C	ENST00000359039.4	-	1	699	c.179A>G	c.(178-180)gAt>gGt	p.D60G	KLHL9_ENST00000537938.1_Intron			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	60	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GAAGATTTCATCTCCATCACC	0.423000													6	77					0	0	0.001168	0	0
SEMA3D	223117	broad.mit.edu	37	7	84751073	84751073	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:84751073G>T	ENST00000284136.6	-	1	178	c.135C>A	c.(133-135)ctC>ctA	p.L45L	SEMA3D_ENST00000444867.1_Silent_p.L45L	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	45	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AGGTTAGCTTGAGTCTTGGAA	0.303000													10	12					3.27435e-08	4.58935e-08	0.020292	1	0
VIT	5212	broad.mit.edu	37	2	36982178	36982178	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:36982178A>T	ENST00000379242.3	+	5	692	c.390A>T	c.(388-390)agA>agT	p.R130S	VIT_ENST00000401530.1_Missense_Mutation_p.R130S|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000457137.2_Missense_Mutation_p.R130S|VIT_ENST00000379241.3_Missense_Mutation_p.R130S|VIT_ENST00000404084.1_Missense_Mutation_p.R108S|VIT_ENST00000389975.3_Missense_Mutation_p.R130S	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	130	LCCL.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				CACGATGGAGAGAATCCTTTA	0.438000													14	51					0	0	0.007413	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11154	11154	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrM:11154T>C	ENST00000361381.2	+	1	395	c.395T>C	c.(394-396)aTc>aCc	p.132_132insT						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CACCTTGGCTATCATCACCCG	0.443000													638	213					0	0	0.014410	0	0
ANK1	286	broad.mit.edu	37	8	41547754	41547754	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:41547754G>T	ENST00000396942.1	-	33	4178	c.4095C>A	c.(4093-4095)ccC>ccA	p.P1365P	ANK1_ENST00000289734.7_Silent_p.P1365P|ANK1_ENST00000352337.4_Silent_p.P1365P|ANK1_ENST00000379758.2_Silent_p.P1365P|ANK1_ENST00000347528.4_Silent_p.P1365P|ANK1_ENST00000396945.1_Silent_p.P1365P|ANK1_ENST00000265709.8_Silent_p.P1406P			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1365					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCTTGGCGCAGGGGGGCATGG	0.637000													4	31					2.56e-06	3.2371e-06	0.009096	1	0
DAPK1	1612	broad.mit.edu	37	9	90321137	90321137	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:90321137G>A	ENST00000469640.2	+	27	3601	c.3226G>A	c.(3226-3228)Gtg>Atg	p.V1076M	DAPK1_ENST00000472284.1_Missense_Mutation_p.V1051M|DAPK1_ENST00000408954.3_Missense_Mutation_p.V1051M|DAPK1_ENST00000358077.5_Missense_Mutation_p.V1051M|DAPK1_ENST00000491893.1_Missense_Mutation_p.V985M			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1051					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						GTTGCTGTCCGTGGAGACCCC	0.642000									Chronic Lymphocytic Leukemia, Familial Clustering of				3	28					0	0	0.004672	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995525	140995525	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:140995525G>T	ENST00000285879.4	+	4	2621	c.2335G>T	c.(2335-2337)Gtc>Ttc	p.V779F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	779							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGAGACCTGTCAGCTCCTT	0.557000										HNSCC(15;0.026)			6	199					2.0095e-06	2.55024e-06	0.001984	1	0
SORCS1	114815	broad.mit.edu	37	10	108459151	108459151	+	Splice_Site	SNP	C	C	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:108459151C>G	ENST00000263054.6	-	9	1241	c.1233_splice	c.e9-1	p.D412_splice	SORCS1_ENST00000344440.6_Splice_Site_p.D412_splice	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	412						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACATGCATGTCCTGTGAAAAG	0.453000													10	26					0	0	0.008291	0	0
NAT6	24142	broad.mit.edu	37	3	50334635	50334635	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:50334635C>T	ENST00000443842.1	-	2	1067	c.260G>A	c.(259-261)cGc>cAc	p.R87H	HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron|NAT6_ENST00000417393.1_Missense_Mutation_p.R87H|HYAL3_ENST00000450982.1_Intron|NAT6_ENST00000354862.4_Missense_Mutation_p.R109H|NAT6_ENST00000443094.2_Missense_Mutation_p.R87H|HYAL3_ENST00000415204.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GCGGGAGGTGCGGCTGCGGGG	0.647000													6	6					0	0	0.004482	0	0
INTU	27152	broad.mit.edu	37	4	128565196	128565196	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:128565196G>T	ENST00000335251.5	+	2	770	c.667G>T	c.(667-669)Ggt>Tgt	p.G223C	INTU_ENST00000296461.5_Missense_Mutation_p.G223C	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	223	PDZ.									breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TATGAAGAGCGGTCAGGTACT	0.483000													25	39					8.24728e-16	1.43915e-15	0.004656	1	0
RRS1	23212	broad.mit.edu	37	8	67341476	67341476	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:67341476G>A	ENST00000320270.2	+	1	214	c.110G>A	c.(109-111)gGc>gAc	p.G37D		NM_015169.3	NP_055984.1	Q15050	RRS1_HUMAN	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	37					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus				kidney(2)|lung(2)	4		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TTTGACCTGGGCAACCTGCTG	0.677000											OREG0018806	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					0	0	0.004672	0	0
HTR3A	3359	broad.mit.edu	37	11	113857446	113857446	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:113857446C>A	ENST00000504030.2	+	7	1357	c.912C>A	c.(910-912)ctC>ctA	p.L304L	HTR3A_ENST00000355556.2_Silent_p.L310L|HTR3A_ENST00000506841.2_Silent_p.L304L|HTR3A_ENST00000535865.1_Silent_p.L48L|HTR3A_ENST00000375498.2_Silent_p.L310L|HTR3A_ENST00000299961.5_Silent_p.L289L			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	304					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GCACTCCTCTCATTGGTAAGG	0.602000													12	41					3.07112e-06	3.86939e-06	0.010729	1	0
DNASE2B	58511	broad.mit.edu	37	1	84864322	84864322	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:84864322G>T	ENST00000370665.3	+	1	108	c.75G>T	c.(73-75)ctG>ctT	p.L25L		NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	25					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TTGGGGTGCTGGGGGCAGCAA	0.463000													12	110					2.27111e-07	3.04853e-07	0.013537	1	0
ARHGAP17	55114	broad.mit.edu	37	16	24953364	24953364	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:24953364C>A	ENST00000289968.6	-	16	1503	c.1434G>T	c.(1432-1434)gaG>gaT	p.E478D	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Missense_Mutation_p.E478D	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	478					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GCCGCTTCCTCTCCAGGGTCC	0.483000													27	73					1.49673e-21	2.72062e-21	0.006230	1	0
SI	6476	broad.mit.edu	37	3	164735438	164735438	+	Silent	SNP	T	T	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:164735438T>G	ENST00000264382.3	-	31	3719	c.3657A>C	c.(3655-3657)ccA>ccC	p.P1219P		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1219	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCCAATAAGCTGGCATGACTG	0.333000										HNSCC(35;0.089)			4	9					0	0	0.014758	0	0
FLT1	2321	broad.mit.edu	37	13	28895700	28895700	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:28895700G>C	ENST00000282397.4	-	23	3325	c.3074C>G	c.(3073-3075)gCg>gGg	p.A1025G	FLT1_ENST00000540678.1_Missense_Mutation_p.A243G|FLT1_ENST00000543394.1_Missense_Mutation_p.A48G	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1025	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity	p.A1025E(1)		NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AATGTTTCTCGCTGCCAGGTC	0.388000													14	52					0	0	0.003163	0	0
CENPJ	55835	broad.mit.edu	37	13	25459510	25459510	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:25459510C>A	ENST00000381884.4	-	13	3566	c.3381G>T	c.(3379-3381)agG>agT	p.R1127S	CENPJ_ENST00000545981.1_3'UTR|CENPJ_ENST00000493190.1_5'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1127					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CAAGTGGCTCCCTGGGAGAGG	0.448000													7	35					0.00198382	0.00217721	0.001984	1	0
PCDHA7	56141	broad.mit.edu	37	5	140215571	140215571	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:140215571G>A	ENST00000525929.1	+	1	1603	c.1603G>A	c.(1603-1605)Gtg>Atg	p.V535M	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.V535M|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTTCCAGGTGAGCGCGCG	0.687000													7	36					0	0	0.016723	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773370	140773370	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:140773370G>T	ENST00000398604.2	+	1	990	c.990G>T	c.(988-990)agG>agT	p.R330S	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGGGGAGGACCAAATTGC	0.393000													15	74					1.33834e-09	2.01327e-09	0.007413	1	0
TENM4	26011	broad.mit.edu	37	11	78381153	78381153	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:78381153G>A	ENST00000278550.7	-	32	6699	c.6237C>T	c.(6235-6237)gcC>gcT	p.A2079A		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AGTCAAAACGGGCGTTGACCA	0.532000													7	19					0	0	0.003080	0	0
GLE1	2733	broad.mit.edu	37	9	131285001	131285001	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:131285001G>C	ENST00000309971.4	+	4	593	c.487G>C	c.(487-489)Gag>Cag	p.E163Q	GLE1_ENST00000372770.4_Missense_Mutation_p.E163Q|GLE1_ENST00000539582.1_Intron	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	163					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						AGCCCTCTCGGAGATGGCATC	0.448000													4	27					0	0	0.014758	0	0
ANGPT1	284	broad.mit.edu	37	8	108315503	108315503	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:108315503T>A	ENST00000520734.1	-	4	586	c.301A>T	c.(301-303)Act>Tct	p.T101S	ANGPT1_ENST00000518386.1_Intron|ANGPT1_ENST00000520052.1_Missense_Mutation_p.T100S			Q15389	ANGP1_HUMAN	angiopoietin 1	301					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			ATATAAATAGTGTAGATTCCA	0.343000													8	63					0	0	0.003080	0	0
CASQ2	845	broad.mit.edu	37	1	116260500	116260500	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:116260500C>T	ENST00000261448.5	-	8	1038	c.799G>A	c.(799-801)Ggg>Agg	p.G267R	CASQ2_ENST00000456138.2_Missense_Mutation_p.G196R	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	267					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		ATGTGGATCCCATTCAAATCA	0.463000													16	85					0	0	0.006122	0	0
FOXP4	116113	broad.mit.edu	37	6	41557832	41557832	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:41557832G>T	ENST00000373060.1	+	11	1739	c.1281G>T	c.(1279-1281)ctG>ctT	p.L427L	FOXP4_ENST00000409208.1_Silent_p.L415L|FOXP4_ENST00000307972.4_Silent_p.L427L|FOXP4_ENST00000373063.3_Silent_p.L414L|FOXP4_ENST00000373057.3_Silent_p.L425L	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	427					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCCTGGCCTGGGCTCTGCCT	0.682000													8	19					3.09899e-07	4.11234e-07	0.004482	1	0
VWA3B	200403	broad.mit.edu	37	2	98779317	98779317	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:98779317C>A	ENST00000477737.1	+	8	1196	c.992C>A	c.(991-993)gCt>gAt	p.A331D	VWA3B_ENST00000451075.2_Missense_Mutation_p.A181D|VWA3B_ENST00000435344.1_Missense_Mutation_p.A331D	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	331										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTTTTAGGAGCTGGAGTCAGA	0.622000													6	20					2.7689e-08	3.89655e-08	0.001984	1	0
TMEM74	157753	broad.mit.edu	37	8	109797367	109797367	+	Splice_Site	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:109797367C>A	ENST00000297459.3	-	2	140		c.e2-1		TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74						autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			TCCGGAAAGTCTGCCAATAGC	0.522000													24	8					1.64293e-13	2.76997e-13	0.018920	1	0
SAAL1	113174	broad.mit.edu	37	11	18105129	18105129	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:18105129C>A	ENST00000524803.1	-	10	1241	c.1192G>T	c.(1192-1194)Gat>Tat	p.D398Y	SAAL1_ENST00000529318.1_Missense_Mutation_p.D400Y|SAAL1_ENST00000300013.4_Missense_Mutation_p.D397Y			Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	398					acute-phase response	extracellular region	binding			breast(2)|large_intestine(5)|lung(8)	15						CATAAAATATCCTTTAAGATT	0.338000													8	22					1.33987e-11	2.13523e-11	0.008291	1	0
LINC01410	103352539	broad.mit.edu	37	9	66466693	66466693	+	RNA	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:66466693G>A	ENST00000424345.1	+	0	1326																											tctataactcgcttggttaca	0.483000													3	3					0	0	0.004672	0	0
CEP128	145508	broad.mit.edu	37	14	81259422	81259422	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:81259422T>A	ENST00000555265.1	-	14	1617	c.1242A>T	c.(1240-1242)aaA>aaT	p.K414N	CEP128_ENST00000281129.3_Missense_Mutation_p.K414N			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	414						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						GCAGTTGCTGTTTTTCCCCAT	0.418000													6	49					0	0	0.001168	0	0
ZNF98	148198	broad.mit.edu	37	19	22574939	22574939	+	Silent	SNP	A	A	T	rs74170714		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:22574939A>T	ENST00000357774.5	-	4	1219	c.1098T>A	c.(1096-1098)acT>acA	p.T366T		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TCTTATGTGTAGTAAGGTGGG	0.383000													3	12					0	0	0.001984	0	0
STAB2	55576	broad.mit.edu	37	12	104149122	104149122	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:104149122C>A	ENST00000388887.2	+	62	6961	c.6757C>A	c.(6757-6759)Cgg>Agg	p.R2253R	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2253	Link.			R -> G (in Ref. 5; BAD18723).	angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GGAGACCGGGCGGGTTGCCTA	0.582000													15	40					1.67942e-08	2.39231e-08	0.006122	1	0
DUSP27	92235	broad.mit.edu	37	1	167097620	167097620	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:167097620C>T	ENST00000361200.2	+	6	3418	c.3252C>T	c.(3250-3252)gcC>gcT	p.A1084A	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Silent_p.A1084A|DUSP27_ENST00000443333.1_Silent_p.A1084A			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1084					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AATTTGGAGCCAAGAGGAAGT	0.522000													6	62					0	0	0.001168	0	0
OR52J3	119679	broad.mit.edu	37	11	5068378	5068378	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:5068378T>C	ENST00000380370.1	+	1	623	c.623T>C	c.(622-624)tTt>tCt	p.F208S		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTTTCTTTCTTTGTTCTGAAC	0.443000													42	84					0	0	0.009718	0	0
CENPJ	55835	broad.mit.edu	37	13	25459511	25459511	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:25459511C>A	ENST00000381884.4	-	13	3565	c.3380G>T	c.(3379-3381)aGg>aTg	p.R1127M	CENPJ_ENST00000545981.1_3'UTR|CENPJ_ENST00000493190.1_5'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1127					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		AAGTGGCTCCCTGGGAGAGGC	0.448000													7	35					0.00198382	0.00217721	0.001984	1	0
IGHV3-16	28447	broad.mit.edu	37	14	106622022	106622022	+	RNA	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:106622022T>C	ENST00000390604.2	-	0	296																											TGCGTCCTACTGCCATTCCAA	0.537000													88	294					0	0	0.014410	0	0
ATRX	546	broad.mit.edu	37	X	76920135	76920135	+	Splice_Site	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:76920135C>A	ENST00000373344.5	-	11	4156	c.3943_splice	c.e11+1	p.E1314_splice	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Splice_Site_p.E1276_splice	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1314					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	GGAGCTCACCCTCATCTCCTG	0.383000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						16	40					9.16793e-09	1.32215e-08	0.004990	1	0
KCNH4	23415	broad.mit.edu	37	17	40321504	40321504	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:40321504G>A	ENST00000264661.3	-	9	1913	c.1581C>T	c.(1579-1581)gaC>gaT	p.D527D	KCNH4_ENST00000607371.1_Silent_p.D527D	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	527					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCTCGTTGGCGTCGATGCCGC	0.632000													4	23					0	0	0.001168	0	0
XIST	7503	broad.mit.edu	37	X	73053169	73053169	+	RNA	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:73053169T>C	ENST00000429829.1	-	0	11476					NR_001564.2																						GAGCCTCTTATAGCTGTTTGC	0.448000													6	33					0	0	0.001984	0	0
ZFR	51663	broad.mit.edu	37	5	32403291	32403291	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:32403291C>T	ENST00000265069.8	-	8	1538	c.1436G>A	c.(1435-1437)aGc>aAc	p.S479N		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	479					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		GTTAGATGTGCTATTAAGAGA	0.398000													7	144					0	0	0.001984	0	0
CCER1	196477	broad.mit.edu	37	12	91347827	91347827	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:91347827G>A	ENST00000358859.2	-	1	1126	c.693C>T	c.(691-693)tcC>tcT	p.S231S	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		CGTCGTTTCCGGAGGATCTGG	0.637000													4	58					0	0	0.014758	0	0
IGHV2-5	28457	broad.mit.edu	37	14	106494256	106494256	+	RNA	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:106494256C>A	ENST00000390597.2	-	0	255																											TGGGCTGTAGCGCTTATCATC	0.542000													11	32					4.68919e-08	6.54611e-08	0.008291	1	0
C18orf63	644041	broad.mit.edu	37	18	72021504	72021504	+	Splice_Site	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:72021504G>T	ENST00000579455.1	+	12	2330		c.e12+1			NM_001174123.1	NP_001167594.1	Q68DL7	CR063_HUMAN	chromosome 18 open reading frame 63											breast(1)	1						TAAGAAGCAGGTAAAAAAAAA	0.348000													8	14					1.12685e-05	1.39458e-05	0.004482	1	0
GLE1	2733	broad.mit.edu	37	9	131285584	131285584	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:131285584G>A	ENST00000309971.4	+	5	713	c.607G>A	c.(607-609)Gag>Aag	p.E203K	GLE1_ENST00000372770.4_Missense_Mutation_p.E203K|GLE1_ENST00000539582.1_5'UTR	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	203					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						GGGACACCAAGAGAAGCTAAA	0.488000													7	86					0	0	0.003080	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36219737	36219737	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:36219737C>A	ENST00000258840.6	-	9	1352	c.962G>T	c.(961-963)gGa>gTa	p.G321V	RALGAPA1_ENST00000554704.1_5'UTR|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.G321V|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.G321V|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.G321V			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	321					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AATATGAGGTCCTGTATGTGG	0.418000													3	17					0.000602214	0.000684602	0.014758	1	0
ATRX	546	broad.mit.edu	37	X	76854957	76854957	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:76854957G>C	ENST00000373344.5	-	25	6093	c.5879C>G	c.(5878-5880)tCa>tGa	p.S1960*	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Nonsense_Mutation_p.S1922*	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1960					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CCGAGATCTTGAATTCCAGAC	0.383000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						12	301					0	0	0.016723	0	0
WDR19	57728	broad.mit.edu	37	4	39233832	39233832	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:39233832C>T	ENST00000399820.3	+	19	2347	c.2193C>T	c.(2191-2193)aaC>aaT	p.N731N	WDR19_ENST00000288634.7_Silent_p.N571N|WDR19_ENST00000515631.1_3'UTR	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	731					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TGTTTACCAACGATTATAACC	0.408000													11	177					0	0	0.016723	0	0
WAS	7454	broad.mit.edu	37	X	48549500	48549500	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:48549500G>A	ENST00000376701.4	+	12	1531	c.1456G>A	c.(1456-1458)Gaa>Aaa	p.E486K		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	486	Asp/Glu-rich (acidic).				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity	p.E486K(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				CCCTCCAGACGAAGGGGAGGA	0.582000			"""Mis, N, F, S"""			lymphoma							4	30					0	0	0.014758	0	0
AIM2	9447	broad.mit.edu	37	1	159035705	159035705	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:159035705G>A	ENST00000368130.4	-	4	1099	c.811C>T	c.(811-813)Cag>Tag	p.Q271*	AIM2_ENST00000481829.1_5'UTR	NM_004833.1	NP_004824.1	O14862	AIM2_HUMAN	absent in melanoma 2	271	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				breast(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(1)	16	all_hematologic(112;0.0429)					CTTACCTTCTGGACTACAAAC	0.363000													29	41					0	0	0.006320	0	0
CYP2C8	1558	broad.mit.edu	37	10	96802716	96802716	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:96802716G>A	ENST00000371270.3	-	7	1174	c.1080C>T	c.(1078-1080)gaC>gaT	p.D360D	CYP2C8_ENST00000539050.1_Silent_p.D274D|CYP2C8_ENST00000535898.1_Silent_p.D258D	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	360					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TGGGGACAAGGTCACTGTATC	0.488000													40	70					0	0	0.007835	0	0
ZNF99	7652	broad.mit.edu	37	19	22939802	22939802	+	Silent	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:22939802T>A	ENST00000397104.3	-	6	2528	c.2529A>T	c.(2527-2529)tcA>tcT	p.S843S						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCCTAAGGGCTGAGAAATTGC	0.343000													13	31					0	0	0.016723	0	0
TTLL7	79739	broad.mit.edu	37	1	84373139	84373139	+	Splice_Site	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:84373139C>A	ENST00000260505.8	-	16	2369	c.1992_splice	c.e16+1	p.V664_splice	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	664					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GATGACCTACCACTTGAGAGT	0.493000													5	43					0.000602214	0.000684602	0.014758	1	0
HMGCLL1	54511	broad.mit.edu	37	6	55360313	55360313	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:55360313C>A	ENST00000398661.2	-	8	920	c.789G>T	c.(787-789)ttG>ttT	p.L263F	HMGCLL1_ENST00000308161.4_Missense_Mutation_p.L201F|HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.L233F|HMGCLL1_ENST00000370850.2_Missense_Mutation_p.L130F	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	263							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TCACACTTTCCAACATTCTTT	0.443000													11	34					0.00829132	0.00893108	0.008291	1	0
STAT4	6775	broad.mit.edu	37	2	191926454	191926454	+	Splice_Site	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:191926454C>T	ENST00000392320.2	-	10	1349		c.e10+1		STAT4_ENST00000358470.4_Splice_Site	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4						JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TTTTTGCCTACCTTAGTTTTA	0.433000													6	312					0	0	0.001984	0	0
HTR1F	3355	broad.mit.edu	37	3	88040437	88040437	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:88040437G>T	ENST00000319595.4	+	1	592	c.538G>T	c.(538-540)Gtt>Ttt	p.V180F		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	180					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	CGACCACATTGTTTCCACCAT	0.383000													14	18					1.15088e-07	1.58132e-07	0.004007	1	0
UNC93A	54346	broad.mit.edu	37	6	167711434	167711434	+	Splice_Site	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:167711434G>A	ENST00000230256.3	+	4	676	c.499_splice	c.e4-1	p.E167_splice	UNC93A_ENST00000366829.2_Intron	NM_018974.3	NP_061847.2	Q86WB7	UN93A_HUMAN	unc-93 homolog A (C. elegans)	167						integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	40		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ACTTCATAGAGACCCTTCCAG	0.532000													4	6					0	0	0.014758	0	0
ITPR2	3709	broad.mit.edu	37	12	26636691	26636691	+	Silent	SNP	C	C	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:26636691C>G	ENST00000381340.3	-	42	6368	c.5952G>C	c.(5950-5952)ctG>ctC	p.L1984L		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1984					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TCTGGTTGACCAGCGCTACAT	0.473000													21	84					0	0	0.010504	0	0
PRDM9	56979	broad.mit.edu	37	5	23524602	23524602	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:23524602C>A	ENST00000296682.3	+	10	1292	c.1110C>A	c.(1108-1110)ggC>ggA	p.G370G		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	370					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TCAAGTGGGGCAGCAAGTGGA	0.478000										HNSCC(3;0.000094)			8	47					5.50884e-06	6.89098e-06	0.013537	1	0
SEMA3E	9723	broad.mit.edu	37	7	82997074	82997074	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:82997074T>C	ENST00000307792.3	-	17	2623	c.2156A>G	c.(2155-2157)tAt>tGt	p.Y719C	SEMA3E_ENST00000427262.1_Missense_Mutation_p.Y659C	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	719					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GAAGTTGCTATAACCGATCAG	0.473000													43	124					0	0	0.009718	0	0
C1orf173	127254	broad.mit.edu	37	1	75038498	75038498	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:75038498T>A	ENST00000326665.5	-	14	3114	c.2896A>T	c.(2896-2898)Aga>Tga	p.R966*	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	966	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCGTCCTCTCTCTTTGATGCT	0.527000													37	98					0	0	0.019004	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3682056	3682056	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:3682056C>T	ENST00000344754.4	-	6	1460	c.1461G>A	c.(1459-1461)ggG>ggA	p.G487G	SIGLEC1_ENST00000202578.4_Silent_p.G487G	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	487	Ig-like C2-type 4.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						ACTTGTACTCCCCACTGTCAG	0.592000													4	14					0	0	0.014758	0	0
DNAH2	146754	broad.mit.edu	37	17	7667525	7667525	+	Silent	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:7667525T>C	ENST00000572933.1	+	20	4730	c.3270T>C	c.(3268-3270)acT>acC	p.T1090T	DNAH2_ENST00000389173.2_Silent_p.T1090T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1090	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACGTGGAGACTCAGATCCCTC	0.562000													27	97					0	0	0.008361	0	0
TRHDE	29953	broad.mit.edu	37	12	72680615	72680615	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:72680615G>C	ENST00000261180.4	+	2	1030	c.934G>C	c.(934-936)Gag>Cag	p.E312Q		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	312					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTCCGTGTTTGAGGAAGATGG	0.398000													6	62					0	0	0.001984	0	0
ROBO4	54538	broad.mit.edu	37	11	124756441	124756441	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:124756441G>T	ENST00000306534.3	-	16	3198	c.2713C>A	c.(2713-2715)Cac>Aac	p.H905N	ROBO4_ENST00000533054.1_Missense_Mutation_p.H760N|RP11-664I21.5_ENST00000524453.1_RNA	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	905					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CGGGCAAAGTGAGCATCAGCG	0.602000													8	14					2.80697e-09	4.15099e-09	0.010729	1	0
MOV10L1	54456	broad.mit.edu	37	22	50563938	50563938	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr22:50563938G>C	ENST00000262794.5	+	11	1770	c.1687G>C	c.(1687-1689)Ggg>Cgg	p.G563R	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Missense_Mutation_p.G563R|MOV10L1_ENST00000540615.1_Missense_Mutation_p.G543R|MOV10L1_ENST00000545383.1_Missense_Mutation_p.G563R	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	563					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AAGAAGGAATGGGGATCTGCT	0.483000													9	21					0	0	0.006214	0	0
PDCD11	22984	broad.mit.edu	37	10	105173785	105173785	+	Silent	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:105173785T>C	ENST00000369797.3	+	10	1342	c.1248T>C	c.(1246-1248)acT>acC	p.T416T		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	416	S1 motif 4.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CAGGGAACACTCACAAGTGTA	0.463000													6	43					0	0	0.001168	0	0
TPTE	7179	broad.mit.edu	37	21	10970051	10970051	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:10970051C>A	ENST00000298232.7	-	6	444	c.77G>T	c.(76-78)aGt>aTt	p.S26I	TPTE_ENST00000361285.4_Missense_Mutation_p.S26I|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.S26I	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	26					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTAAATTCACTTGTCTGTGG	0.378000													15	165					3.57192e-18	6.36021e-18	0.006122	1	0
CETP	1071	broad.mit.edu	37	16	57012021	57012021	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:57012021A>C	ENST00000200676.3	+	11	1130	c.1000A>C	c.(1000-1002)Agc>Cgc	p.S334R	CETP_ENST00000379780.2_Missense_Mutation_p.S274R|CETP_ENST00000566128.1_Missense_Mutation_p.S269R	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	334					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						CGGCTTCCCCAGCCAGGCCCA	0.587000													6	20					0	0	0.001984	0	0
HAND1	9421	broad.mit.edu	37	5	153857468	153857468	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:153857468C>T	ENST00000231121.2	-	1	356	c.101G>A	c.(100-102)cGc>cAc	p.R34H		NM_004821.2	NP_004812.1	O96004	HAND1_HUMAN	heart and neural crest derivatives expressed 1	34					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CTGATGACAGCGCGAGGCCGG	0.692000													6	29					0	0	0.001984	0	0
ZNF260	339324	broad.mit.edu	37	19	37005994	37005994	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:37005994A>T	ENST00000523638.1	-	3	1268	c.147T>A	c.(145-147)caT>caA	p.H49Q	ZNF260_ENST00000593142.1_Missense_Mutation_p.H49Q|ZNF260_ENST00000592282.1_Missense_Mutation_p.H49Q|ZNF260_ENST00000588993.1_Missense_Mutation_p.H49Q	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	49					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TCTCTCCAGTATGCATTTTCT	0.378000													12	70					0	0	0.013537	0	0
ZNF165	7718	broad.mit.edu	37	6	28056534	28056534	+	Silent	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:28056534G>C	ENST00000377325.1	+	4	1300	c.744G>C	c.(742-744)tcG>tcC	p.S248S		NM_003447.3	NP_003438.1	P49910	ZN165_HUMAN	zinc finger protein 165	248					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGAGACTCTCGTCTGCCCAGG	0.438000													35	93					0	0	0.015359	0	0
FLI1	2313	broad.mit.edu	37	11	128680587	128680587	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:128680587A>T	ENST00000344954.6	+	9	1352	c.964A>T	c.(964-966)Aga>Tga	p.R322*	FLI1_ENST00000525560.1_Nonsense_Mutation_p.R162*|FLI1_ENST00000281428.8_Nonsense_Mutation_p.R289*|FLI1_ENST00000429175.2_Nonsense_Mutation_p.R355*|FLI1_ENST00000534087.1_Nonsense_Mutation_p.R322*			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	355					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GCACGGCAAAAGATATGCTTA	0.488000			T	EWSR1	Ewing sarcoma								17	47					0	0	0.006122	0	0
CECR6	27439	broad.mit.edu	37	22	17601064	17601064	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr22:17601064C>A	ENST00000331437.3	-	1	1079	c.954G>T	c.(952-954)tgG>tgT	p.W318C	CECR6_ENST00000399875.1_Intron	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	318										haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		AGTAGATAAGCCAGGCCAGGT	0.731000													10	16					2.80697e-09	4.15099e-09	0.010729	1	0
TRBV6-1	28606	broad.mit.edu	37	7	142028511	142028511	+	RNA	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:142028511G>T	ENST00000390353.2	+	0	302																											GTCCCCAATGGCTACAATGTC	0.517000													63	141					2.02627e-32	3.74163e-32	0.014410	1	0
KMT2C	58508	broad.mit.edu	37	7	151856048	151856048	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:151856048G>A	ENST00000355193.2	-	44	11788	c.11570C>T	c.(11569-11571)aCg>aTg	p.T3857M	KMT2C_ENST00000262189.6_Missense_Mutation_p.T3857M					lysine (K)-specific methyltransferase 2C																		TTTCTCACCCGTCCTCTGAGT	0.478000													21	118					0	0	0.010504	0	0
TEX14	56155	broad.mit.edu	37	17	56638913	56638913	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:56638913C>A	ENST00000389934.3	-	30	4362	c.4245G>T	c.(4243-4245)gtG>gtT	p.V1415V	TEX14_ENST00000584699.1_5'UTR|TEX14_ENST00000349033.5_Silent_p.V1375V|TEX14_ENST00000240361.8_Silent_p.V1421V	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1421						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTTGTAGCTCCACGCTCTCCT	0.478000													11	93					0.000422831	0.000485422	0.004007	1	0
WDTC1	23038	broad.mit.edu	37	1	27624556	27624556	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:27624556G>C	ENST00000319394.3	+	12	1721	c.1186G>C	c.(1186-1188)Gcc>Ccc	p.A396P	WDTC1_ENST00000361771.3_Missense_Mutation_p.A395P	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	396							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CCCTCACAATGCCATGCTTTA	0.567000													31	47					0	0	0.019004	0	0
MED24	9862	broad.mit.edu	37	17	38188962	38188962	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:38188962C>A	ENST00000394126.1	-	8	1369	c.951G>T	c.(949-951)ggG>ggT	p.G317G	MED24_ENST00000356271.3_Silent_p.G279G|MED24_ENST00000501516.3_Silent_p.G311G|MED24_ENST00000394128.2_Silent_p.G292G|MED24_ENST00000394127.2_Silent_p.G279G			O75448	MED24_HUMAN	mediator complex subunit 24	292					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					ACTCAATGAGCCCCACGAAGC	0.572000													19	43					1.55795e-14	2.65231e-14	0.012319	1	0
VGLL3	389136	broad.mit.edu	37	3	87018027	87018027	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:87018027G>C	ENST00000398399.2	-	3	1013	c.650C>G	c.(649-651)cCa>cGa	p.P217R	VGLL3_ENST00000383698.3_Missense_Mutation_p.P217R	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCTGTAGGATGGGCTCACCTG	0.607000													19	55					0	0	0.008871	0	0
OR1A2	26189	broad.mit.edu	37	17	3101421	3101421	+	Silent	SNP	C	C	T	rs150553361	byFrequency	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:3101421C>T	ENST00000381951.1	+	1	609	c.609C>T	c.(607-609)gtC>gtT	p.V203V		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						ACCTAGGGGTCGGCGTTTTCT	0.433000													34	135					0	0	0.019004	0	0
HSPG2	3339	broad.mit.edu	37	1	22157749	22157749	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:22157749C>A	ENST00000374695.3	-	84	11600	c.11521G>T	c.(11521-11523)Ggc>Tgc	p.G3841C		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3841	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGGAGATGCCGTGCGCCGTG	0.682000													12	37					2.27111e-07	3.04853e-07	0.013537	1	0
OR14K1	343170	broad.mit.edu	37	1	247902089	247902089	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:247902089A>G	ENST00000283225.2	+	1	173	c.173A>G	c.(172-174)tAc>tGc	p.Y58C	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						ATGGCAATGTACTTTTTCCTC	0.478000													38	86					0	0	0.007835	0	0
GPR112	139378	broad.mit.edu	37	X	135429739	135429739	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:135429739C>T	ENST00000394143.1	+	6	4165	c.3874C>T	c.(3874-3876)Cca>Tca	p.P1292S	GPR112_ENST00000412101.1_Missense_Mutation_p.P1087S|GPR112_ENST00000287534.4_Missense_Mutation_p.P1229S|GPR112_ENST00000394141.1_Missense_Mutation_p.P1087S|GPR112_ENST00000370652.1_Missense_Mutation_p.P1292S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1292					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCGGGGTACTCCATCTTTGGA	0.443000													37	59					0	0	0.017118	0	0
GJB4	127534	broad.mit.edu	37	1	35226896	35226896	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:35226896A>G	ENST00000339480.1	+	2	411	c.41A>G	c.(40-42)aAc>aGc	p.N14S		NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	14					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AGTGGCGTGAACAAGTACTCC	0.587000													5	69					0	0	0.014758	0	0
CAMKV	79012	broad.mit.edu	37	3	49897636	49897636	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:49897636T>A	ENST00000477224.1	-	10	1388	c.910A>T	c.(910-912)Att>Ttt	p.I304F	CAMKV_ENST00000463537.1_Missense_Mutation_p.I304F|CAMKV_ENST00000296471.7_Missense_Mutation_p.I276F|CAMKV_ENST00000467248.1_Missense_Mutation_p.I229F|CAMKV_ENST00000466940.1_Missense_Mutation_p.I261F|CAMKV_ENST00000488336.1_Missense_Mutation_p.I304F			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	304						cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TTCTTTTCAATCTGGGCACAG	0.473000													7	20					0	0	0.001984	0	0
OR5M1	390168	broad.mit.edu	37	11	56380754	56380754	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:56380754G>A	ENST00000526538.1	-	1	224	c.225C>T	c.(223-225)tcC>tcT	p.S75S		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GAGTAACATTGGAAGAATAGC	0.468000													37	114					0	0	0.005524	0	0
ITGAE	3682	broad.mit.edu	37	17	3649219	3649219	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:3649219G>T	ENST00000263087.4	-	18	2256	c.2158C>A	c.(2158-2160)Ctc>Atc	p.L720I		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	720					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GCCTCGCGGAGGCCTGGGAAT	0.612000													10	48					7.03913e-09	1.01936e-08	0.013537	1	0
OR5M11	219487	broad.mit.edu	37	11	56310370	56310370	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:56310370A>G	ENST00000528616.2	-	1	387	c.364T>C	c.(364-366)Tat>Cat	p.Y122H		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						ATGGCCACATAGCGGTCATAG	0.473000													5	48					0	0	0.001168	0	0
FAM83C	128876	broad.mit.edu	37	20	33874426	33874426	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:33874426C>T	ENST00000374408.3	-	4	2252	c.2156G>A	c.(2155-2157)cGg>cAg	p.R719Q		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	719										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CAGGGTCAGCCGTTTCTCATC	0.557000													5	76					0	0	0.001168	0	0
RP1L1	94137	broad.mit.edu	37	8	10469930	10469930	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:10469930T>A	ENST00000382483.3	-	4	1901	c.1678A>T	c.(1678-1680)Agg>Tgg	p.R560W		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	560					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GTCTCGGCCCTTGCCTTGCCT	0.647000													5	8					0	0	0.001168	0	0
PIK3C3	5289	broad.mit.edu	37	18	39623730	39623730	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:39623730G>T	ENST00000262039.4	+	20	2223	c.2137G>T	c.(2137-2139)Ggg>Tgg	p.G713W	PIK3C3_ENST00000398870.3_Missense_Mutation_p.G650W|PIK3C3_ENST00000587402.1_Missense_Mutation_p.G60W|PIK3C3_ENST00000589056.1_Missense_Mutation_p.G60W|PIK3C3_ENST00000593098.1_Missense_Mutation_p.G198W	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	713	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						AAGTGAGAATGGGCCAAATGG	0.338000										TSP Lung(28;0.18)			15	48					6.94344e-10	1.05359e-09	0.006122	1	0
GLYATL1	92292	broad.mit.edu	37	11	58722740	58722740	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:58722740G>A	ENST00000300079.5	+	6	548	c.498G>A	c.(496-498)acG>acA	p.T166T	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.T135T	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	135						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	TCTTGGTTACGGAAGATATTC	0.443000													26	72					0	0	0.018920	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459813	66459813	+	RNA	SNP	G	G	A	rs10752517	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:66459813G>A	ENST00000424345.1	+	0	73																											tccaggatttgtccccagtgc	0.343000													4	21					0	0	0.009096	0	0
GYS2	2998	broad.mit.edu	37	12	21757474	21757474	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:21757474C>A	ENST00000261195.2	-	1	307	c.53G>T	c.(52-54)tGg>tTg	p.W18L		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	18					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TTCGACTTCCCACTGGGGAAG	0.483000													24	36					5.35356e-11	8.49269e-11	0.016522	1	0
RYR2	6262	broad.mit.edu	37	1	237872294	237872294	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:237872294G>T	ENST00000366574.2	+	69	10355	c.10038G>T	c.(10036-10038)ggG>ggT	p.G3346G	RYR2_ENST00000360064.6_Silent_p.G3344G|RYR2_ENST00000542537.1_Silent_p.G3330G	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3346					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGCCAGGGGGGACATGTCGG	0.483000													19	30					1.01871e-10	1.59431e-10	0.008871	1	0
CEP112	201134	broad.mit.edu	37	17	64171266	64171266	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:64171266C>A	ENST00000392769.2	-	4	584	c.366G>T	c.(364-366)tgG>tgT	p.W122C	CEP112_ENST00000537949.1_Missense_Mutation_p.W122C|CEP112_ENST00000535342.2_Missense_Mutation_p.W122C	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	122						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						CACCCAGTACCCAGGCTGGTA	0.388000													8	51					5.68852e-11	8.98324e-11	0.004482	1	0
LILRB2	10288	broad.mit.edu	37	19	54778643	54778643	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:54778643T>A	ENST00000391748.1	-	14	1815	c.1688A>T	c.(1687-1689)cAg>cTg	p.Q563L	LILRB2_ENST00000434421.1_Missense_Mutation_p.Q448L|LILRB2_ENST00000391746.1_3'UTR|LILRB2_ENST00000314446.5_Missense_Mutation_p.Q563L|LILRB2_ENST00000391749.4_Missense_Mutation_p.Q564L	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	564					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCTGTGCAGCTGGGCGTAGGT	0.652000													9	43					0	0	0.010729	0	0
TRHDE	29953	broad.mit.edu	37	12	73012754	73012754	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:73012754C>T	ENST00000261180.4	+	13	2366	c.2270C>T	c.(2269-2271)gCc>gTc	p.A757V		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	757					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TGGCATGCTGCCAGCCGAGCT	0.358000													8	22					0	0	0.010729	0	0
FGD3	89846	broad.mit.edu	37	9	95768376	95768376	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:95768376G>A	ENST00000375482.3	+	6	1247	c.751G>A	c.(751-753)Gtc>Atc	p.V251I	FGD3_ENST00000337352.6_Missense_Mutation_p.V251I|FGD3_ENST00000416701.2_Missense_Mutation_p.V251I	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	251	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						CGGCGAGTATGTCAAGAACTT	0.557000													4	36					0	0	0.009096	0	0
ALK	238	broad.mit.edu	37	2	29917779	29917779	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:29917779C>A	ENST00000389048.3	-	3	1795	c.889G>T	c.(889-891)Gag>Tag	p.E297*	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	297	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGGGAGGCCTCCTCGGAGGGG	0.617000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				27	66					5.90632e-09	8.58878e-09	0.012213	1	0
TMEM145	284339	broad.mit.edu	37	19	42827827	42827827	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:42827827G>T	ENST00000301204.3	+	14	1328	c.1287G>T	c.(1285-1287)ggG>ggT	p.G429G		NM_173633.2	NP_775904.2	Q8NBT3	TM145_HUMAN	transmembrane protein 145	429						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GACCCGGAGGGAGCCAATCCG	0.622000													9	29					5.4927e-09	8.02073e-09	0.004482	1	0
ITPR2	3709	broad.mit.edu	37	12	26572062	26572062	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:26572062T>C	ENST00000381340.3	-	50	7446	c.7030A>G	c.(7030-7032)Atg>Gtg	p.M2344V	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2344					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AGAAAGGCCATATCCAGGATG	0.458000													10	39					0	0	0.010729	0	0
RPL7L1	285855	broad.mit.edu	37	6	42847687	42847687	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:42847687A>T	ENST00000493763.1	+	1	315	c.12A>T	c.(10-12)caA>caT	p.Q4H	RPL7L1_ENST00000424341.2_Missense_Mutation_p.Q4H|RPL7L1_ENST00000602561.1_Missense_Mutation_p.Q4H|RPL7L1_ENST00000397415.3_3'UTR|RPL7L1_ENST00000304734.5_Missense_Mutation_p.Q4H	NM_198486.2	NP_940888.2	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	4					translation	large ribosomal subunit	protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(1)|lung(3)	6	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			TGGCGGAGCAAGAGTGAGTGT	0.532000													8	38					0	0	0.004482	0	0
TPR	7175	broad.mit.edu	37	1	186326650	186326650	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:186326650G>A	ENST00000367478.3	-	14	1899	c.1603C>T	c.(1603-1605)Cag>Tag	p.Q535*	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	535					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ACTAGATGCTGTGATATTACC	0.403000			T	NTRK1	papillary thyroid								28	41					0	0	0.008361	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397204	51397204	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:51397204A>T	ENST00000327536.5	-	1	269	c.170T>A	c.(169-171)cTt>cAt	p.L57H	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	57										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GTGCTGACCAAGTCCCTTTCC	0.547000													12	119					0	0	0.013537	0	0
SIRPB2	284759	broad.mit.edu	37	20	1471924	1471924	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:1471924A>T	ENST00000359801.3	-	1	118	c.82T>A	c.(82-84)Tca>Aca	p.S28T	SIRPB2_ENST00000537284.1_5'UTR|SIRPB2_ENST00000381630.1_Missense_Mutation_p.S28T|SIRPB2_ENST00000444444.1_Missense_Mutation_p.S28T	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	28						integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CACTTACCTGAGGGGACAAGG	0.622000													5	18					0	0	0.014758	0	0
OR1J2	26740	broad.mit.edu	37	9	125274018	125274018	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:125274018G>T	ENST00000335302.5	+	1	938	c.938G>T	c.(937-939)tGg>tTg	p.W313L		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						TTTTTCTCTTGGTGACATCTG	0.373000													15	30					1.52009e-12	2.50241e-12	0.003163	1	0
ANXA5	308	broad.mit.edu	37	4	122604575	122604575	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:122604575C>A	ENST00000296511.5	-	5	532	c.247G>T	c.(247-249)Gct>Tct	p.A83S	ANXA5_ENST00000515017.1_Intron|ANXA5_ENST00000501272.2_Missense_Mutation_p.A23S|ANXA5_ENST00000509016.1_5'UTR	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	83					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						TTCATCAGAGCCACAATTAAT	0.353000													8	91					0.00307968	0.00335877	0.003080	1	0
SORCS1	114815	broad.mit.edu	37	10	108412234	108412234	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:108412234C>A	ENST00000263054.6	-	18	2388	c.2381G>T	c.(2380-2382)gGg>gTg	p.G794V	SORCS1_ENST00000369698.1_Missense_Mutation_p.G329V|SORCS1_ENST00000344440.6_Missense_Mutation_p.G794V	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	794						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CGGGGCTTTCCCTGGGCACTT	0.517000													14	40					3.32936e-07	4.40131e-07	0.006122	1	0
RALGAPA1	253959	broad.mit.edu	37	14	36207850	36207850	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:36207850C>A	ENST00000258840.6	-	12	1846	c.1456G>T	c.(1456-1458)Ggg>Tgg	p.G486W	RALGAPA1_ENST00000554704.1_5'UTR|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.G486W|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.G486W|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.G486W			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	486					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GTATTGGTCCCATTTTCCTGA	0.378000													6	126					8.12818e-05	9.58357e-05	0.001984	1	0
OR2G6	391211	broad.mit.edu	37	1	248685578	248685578	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:248685578G>A	ENST00000343414.4	+	1	663	c.631G>A	c.(631-633)Gtg>Atg	p.V211M		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATTGTCCCGGTGTTACTCAT	0.483000													33	34					0	0	0.015359	0	0
SYPL2	284612	broad.mit.edu	37	1	110022016	110022016	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:110022016A>G	ENST00000369872.3	+	6	881	c.665A>G	c.(664-666)aAc>aGc	p.N222S	SYPL2_ENST00000401021.3_Missense_Mutation_p.N158S	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	222	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCTTTATCAACTTCTTCCTG	0.567000													5	120					0	0	0.001168	0	0
ERCC6	2074	broad.mit.edu	37	10	50668435	50668435	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:50668435G>T	ENST00000355832.5	-	20	4124	c.4046C>A	c.(4045-4047)cCa>cAa	p.P1349Q	RP11-123B3.2_ENST00000423283.1_RNA|ERCC6_ENST00000465653.1_5'UTR|ERCC6_ENST00000542458.1_Missense_Mutation_p.P719Q	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	1349					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CTTCTCTGTTGGAGATGTTGA	0.373000								Direct reversal of damage;Nucleotide excision repair (NER)					14	41					4.36969e-10	6.71816e-10	0.016723	1	0
CDH6	1004	broad.mit.edu	37	5	31299735	31299735	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:31299735C>A	ENST00000265071.2	+	5	1073	c.808C>A	c.(808-810)Cag>Aag	p.Q270K	CDH6_ENST00000514738.1_Missense_Mutation_p.Q215K	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	270	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.Q270K(1)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CCGATTCCCCCAGAGTAGGAA	0.413000													12	31					6.42651e-13	1.07314e-12	0.010729	1	0
PMEPA1	56937	broad.mit.edu	37	20	56227579	56227579	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:56227579G>A	ENST00000341744.3	-	4	713	c.394C>T	c.(394-396)Cgc>Tgc	p.R132C	PMEPA1_ENST00000347215.4_Missense_Mutation_p.R97C|PMEPA1_ENST00000395816.3_Missense_Mutation_p.R82C|PMEPA1_ENST00000265626.4_Missense_Mutation_p.R82C|PMEPA1_ENST00000395814.1_Missense_Mutation_p.R82C	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	132					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GGCTGGAAGCGGTGGAAGCGC	0.711000													7	18					0	0	0.004482	0	0
ARSF	416	broad.mit.edu	37	X	3028172	3028172	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:3028172C>A	ENST00000381127.1	+	10	1490	c.1269C>A	c.(1267-1269)gtC>gtA	p.V423V	ARSF_ENST00000359361.2_Silent_p.V423V|ARSF_ENST00000537104.1_Silent_p.V423V	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	423						extracellular region	arylsulfatase activity|metal ion binding	p.V423V(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTGCAGGGTCATTGACGGCC	0.557000													7	12					0.000157383	0.000183089	0.003080	1	0
NEK10	152110	broad.mit.edu	37	3	27161276	27161276	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:27161276G>T	ENST00000429845.2	-	36	3698	c.3336C>A	c.(3334-3336)aaC>aaA	p.N1112K	NEK10_ENST00000383771.4_Missense_Mutation_p.N414K|NEK10_ENST00000383770.3_Missense_Mutation_p.N367K|NEK10_ENST00000295720.6_Missense_Mutation_p.N424K			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	1112							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GGGACAGGCTGTTTCCACCGG	0.398000													14	15					1.52009e-12	2.50241e-12	0.003163	1	0
PDE11A	50940	broad.mit.edu	37	2	178565928	178565928	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:178565928G>T	ENST00000286063.5	-	14	2482	c.2165C>A	c.(2164-2166)gCc>gAc	p.A722D	PDE11A_ENST00000449286.2_Missense_Mutation_p.A364D|PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000389683.3_Missense_Mutation_p.A278D|PDE11A_ENST00000409504.1_Missense_Mutation_p.A364D|AC012499.1_ENST00000412133.1_RNA|PDE11A_ENST00000358450.4_Missense_Mutation_p.A472D|AC012499.1_ENST00000450227.1_RNA	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	722	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding	p.A472V(1)|p.A722V(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTGGGCCAGGGCAGAGCCACT	0.522000									Primary Pigmented Nodular Adrenocortical Disease, Familial				11	17					0.000673444	0.000763091	0.008291	1	0
MAGEL2	54551	broad.mit.edu	37	15	23890168	23890168	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:23890168A>T	ENST00000532292.1	-	1	1007	c.913T>A	c.(913-915)Tgg>Agg	p.W305R		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGGCCCTGCCAGTCATGAAAG	0.632000													4	8					0	0	0.003080	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98774917	98774917	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:98774917G>T	ENST00000407474.3	+	4	1541	c.1028G>T	c.(1027-1029)aGt>aTt	p.S343I				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	78					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TCACCTGTTAGTTCTACTCAA	0.373000													14	22					4.3838e-07	5.75168e-07	0.016723	1	0
ALG1L	200810	broad.mit.edu	37	3	125651539	125651539	+	Silent	SNP	A	A	C	rs147593769	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:125651539A>C	ENST00000340333.3	-	3	277	c.114T>G	c.(112-114)ctT>ctG	p.L38L		NM_001015050.2|NM_001195223.1	NP_001015050.2|NP_001182152.1	Q6GMV1	ALG1L_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	38							transferase activity, transferring glycosyl groups			large_intestine(2)|lung(2)	4						CATCAAGAGTAAGTTGTTCAA	0.423000													4	22					0	0	0.009096	0	0
CRHR2	1395	broad.mit.edu	37	7	30693187	30693187	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:30693187G>A	ENST00000471646.1	-	12	1542	c.1125C>T	c.(1123-1125)caC>caT	p.H375H	CRHR2_ENST00000341843.4_Silent_p.H361H|CRHR2_ENST00000348438.4_Silent_p.H402H|CRHR2_ENST00000506074.2_3'UTR	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	375					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCTGCCAGCGGTGCCACCTCT	0.642000													6	63					0	0	0.001984	0	0
ANKRD44	91526	broad.mit.edu	37	2	197858365	197858365	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:197858365C>A	ENST00000282272.8	-	26	2840	c.2841G>T	c.(2839-2841)aaG>aaT	p.K947N		NM_001195144.1	NP_001182073.1	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	955							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CAACTACCACCTTTAAGCCAT	0.463000													6	4					0.00116845	0.00130284	0.001168	1	0
ARRDC4	91947	broad.mit.edu	37	15	98509183	98509183	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:98509183G>C	ENST00000268042.6	+	3	597	c.433G>C	c.(433-435)Gtg>Ctg	p.V145L	ARRDC4_ENST00000538249.1_Missense_Mutation_p.V58L	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	145					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TGTGCGGGCAGTGTTGGAACG	0.433000													10	27					0	0	0.008291	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891408	2891408	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:2891408G>C	ENST00000254528.3	+	4	1442	c.1283G>C	c.(1282-1284)gGa>gCa	p.G428A		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	428					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		ATGCTGAATGGAAGACTGGAC	0.443000													12	39					0	0	0.010729	0	0
TYR	7299	broad.mit.edu	37	11	88911387	88911387	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:88911387G>T	ENST00000263321.5	+	1	768	c.266G>T	c.(265-267)tGc>tTc	p.C89F	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	89			C -> R (in OCA1A; dbSNP:rs28940877).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	AATAGGACCTGCCAGTGCTCT	0.502000													5	36					3.59834e-05	4.37568e-05	0.001168	1	0
SIGLEC6	946	broad.mit.edu	37	19	52033197	52033197	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:52033197G>C	ENST00000346477.3	-	4	813	c.745C>G	c.(745-747)Ctg>Gtg	p.L249V	SIGLEC6_ENST00000436458.1_Missense_Mutation_p.L213V|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.L276V|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.L265V|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.L265V|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.L254V	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	265	Ig-like C2-type 2.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGGCCCTCCAGGACAGGGAGG	0.607000													7	27					0	0	0.006214	0	0
FLG	2312	broad.mit.edu	37	1	152282882	152282882	+	Missense_Mutation	SNP	C	C	T	rs147239265	byFrequency	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:152282882C>T	ENST00000368799.1	-	3	4515	c.4480G>A	c.(4480-4482)Ggg>Agg	p.G1494R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1494	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTTGACCCCGGGTGTCCA	0.582000									Ichthyosis				26	187					0	0	0.005443	0	0
UBE2E2	7325	broad.mit.edu	37	3	23574055	23574055	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:23574055G>T	ENST00000396703.1	+	5	551	c.371G>T	c.(370-372)cGa>cTa	p.R124L	UBE2E2_ENST00000425792.1_Missense_Mutation_p.R124L	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	124					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						GTTACCTTCCGAACAAGAATC	0.318000													3	12					0.00024832	0.000286966	0.009096	1	0
EMP3	2014	broad.mit.edu	37	19	48830831	48830831	+	Silent	SNP	G	G	T	rs139549534		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:48830831G>T	ENST00000270221.6	+	3	433	c.132G>T	c.(130-132)acG>acT	p.T44T	EMP3_ENST00000597279.1_Silent_p.T44T|EMP3_ENST00000596315.1_5'UTR	NM_001425.2	NP_001416.1	P54852	EMP3_HUMAN	epithelial membrane protein 3	44					cell growth|negative regulation of cell proliferation	integral to membrane				lung(1)	1		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		ACGACTGCACGTGGAACAACG	0.552000													8	31					1.08611e-07	1.49823e-07	0.010729	1	0
ZNF676	163223	broad.mit.edu	37	19	22363036	22363036	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:22363036G>T	ENST00000397121.2	-	3	1800	c.1483C>A	c.(1483-1485)Cat>Aat	p.H495N		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ATTATCTTATGTTTAGTAAGG	0.378000													12	34					1.08611e-07	1.49823e-07	0.010729	1	0
OR4K13	390433	broad.mit.edu	37	14	20502530	20502530	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:20502530G>A	ENST00000315693.2	-	1	389	c.388C>T	c.(388-390)Ctc>Ttc	p.L130F		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATGTAATGGAGGGGTTTGCAT	0.468000													24	88					0	0	0.004656	0	0
ATRNL1	26033	broad.mit.edu	37	10	117001379	117001379	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:117001379G>T	ENST00000355044.3	+	10	1678	c.1552G>T	c.(1552-1554)Ggg>Tgg	p.G518W		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	518						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GAAAGAAAGTGGGTTTGCCAG	0.328000													7	14					2.0095e-06	2.55024e-06	0.001984	1	0
SPATA18	132671	broad.mit.edu	37	4	52938246	52938246	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:52938246G>T	ENST00000295213.4	+	6	1056	c.682G>T	c.(682-684)Gat>Tat	p.D228Y	SPATA18_ENST00000506829.1_3'UTR|SPATA18_ENST00000419395.2_Missense_Mutation_p.D196Y	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	228					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AGCCATGTCCGATTATAAGAA	0.502000													33	77					2.51541e-25	4.59622e-25	0.021022	1	0
SIRT3	23410	broad.mit.edu	37	11	216720	216720	+	Splice_Site	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:216720T>C	ENST00000382743.4	-	7	1282		c.e7-2		SIRT3_ENST00000529382.1_Splice_Site|SIRT3_ENST00000525319.1_Splice_Site|SIRT3_ENST00000524564.1_Splice_Site|SIRT3_ENST00000532956.1_Splice_Site	NM_001017524.2|NM_012239.5	NP_001017524.1|NP_036371.1	Q9NTG7	SIRT3_HUMAN	sirtuin 3						chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			endometrium(1)|lung(5)|urinary_tract(1)	7		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		TCCATCAAGCTGGAATACAGA	0.463000													3	82					0	0	0.004672	0	0
ZNF91	7644	broad.mit.edu	37	19	23542621	23542621	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:23542621C>A	ENST00000300619.7	-	4	3365	c.3160G>T	c.(3160-3162)Gaa>Taa	p.E1054*	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Nonsense_Mutation_p.E1022*	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1054						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTGCCACATTCTTCACACTTG	0.358000													12	48					0.00010058	0.000117793	0.013537	1	0
OR52N1	79473	broad.mit.edu	37	11	5809704	5809704	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:5809704C>T	ENST00000317078.1	-	1	342	c.343G>A	c.(343-345)Ggg>Agg	p.G115R	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATGAGCACCCCAGACTCCATC	0.493000													24	85					0	0	0.021523	0	0
ALLC	55821	broad.mit.edu	37	2	3743369	3743369	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:3743369C>A	ENST00000252505.3	+	8	736	c.574C>A	c.(574-576)Ccc>Acc	p.P192T	ALLC_ENST00000471711.1_3'UTR	NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	211							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		TGCAACTGACCCCAAAGAACC	0.423000										HNSCC(21;0.051)			5	26					3.59834e-05	4.37568e-05	0.001168	1	0
LAMC1	3915	broad.mit.edu	37	1	183106849	183106849	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:183106849G>T	ENST00000258341.4	+	26	4617	c.4360G>T	c.(4360-4362)Gtt>Ttt	p.V1454F		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	1454	Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTTGCAGAAGTTACAGATCT	0.383000													29	43					7.11191e-15	1.22269e-14	0.013726	1	0
SLC26A8	116369	broad.mit.edu	37	6	35911790	35911790	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:35911790G>T	ENST00000490799.1	-	20	3153	c.2800C>A	c.(2800-2802)Ccg>Acg	p.P934T	SLC26A8_ENST00000394602.2_Missense_Mutation_p.P829T|SLC26A8_ENST00000355574.2_Missense_Mutation_p.P934T	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	934	Interaction with RACGAP1.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GCCATAGACGGATGATACATA	0.547000													5	171					8.12818e-05	9.58357e-05	0.001984	1	0
RYR2	6262	broad.mit.edu	37	1	237765336	237765336	+	Silent	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:237765336T>C	ENST00000366574.2	+	35	4925	c.4608T>C	c.(4606-4608)agT>agC	p.S1536S	RYR2_ENST00000360064.6_Silent_p.S1534S|RYR2_ENST00000542537.1_Silent_p.S1520S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1536	4 X approximate repeats.|B30.2/SPRY 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGAACCGAGTACAAAATTAT	0.308000													7	42					0	0	0.001984	0	0
SIK3	23387	broad.mit.edu	37	11	116747710	116747710	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:116747710C>A	ENST00000375300.1	-	7	919	c.914G>T	c.(913-915)cGc>cTc	p.R305L	SIK3_ENST00000375288.1_5'UTR|SIK3_ENST00000446921.2_Missense_Mutation_p.R305L|SIK3_ENST00000542607.1_Missense_Mutation_p.R247L|SIK3_ENST00000434315.2_Missense_Mutation_p.R146L|SIK3_ENST00000292055.4_Missense_Mutation_p.R247L			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	247	UBA.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						CATGGAGAGGCGCTTATTGGG	0.552000													19	60					3.51602e-12	5.65479e-12	0.008871	1	0
INPP4B	8821	broad.mit.edu	37	4	143130048	143130048	+	Splice_Site	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:143130048C>A	ENST00000513000.1	-	14	1401		c.e14+1		INPP4B_ENST00000509777.1_Splice_Site|INPP4B_ENST00000308502.4_Splice_Site|INPP4B_ENST00000508116.1_Splice_Site|INPP4B_ENST00000262992.4_Splice_Site	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa						signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TGCTTCCACACCTGTTTCCTT	0.348000													10	36					6.40141e-05	7.651e-05	0.010729	1	0
KIAA1755	85449	broad.mit.edu	37	20	36870263	36870263	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:36870263G>T	ENST00000279024.4	-	3	541	c.270C>A	c.(268-270)gtC>gtA	p.V90V		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	90										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GTGCCAAGTGGACCACAACTT	0.562000													16	123					6.94344e-10	1.05359e-09	0.006122	1	0
CRB1	23418	broad.mit.edu	37	1	197411417	197411417	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:197411417G>C	ENST00000367400.3	+	11	4135	c.4000G>C	c.(4000-4002)Gtg>Ctg	p.V1334L	CRB1_ENST00000367397.1_3'UTR|CRB1_ENST00000535699.1_Missense_Mutation_p.V1310L|CRB1_ENST00000544212.1_Missense_Mutation_p.V815L|CRB1_ENST00000367399.2_Missense_Mutation_p.V1222L|CRB1_ENST00000538660.1_Missense_Mutation_p.V798L|RP11-75C23.1_ENST00000422250.1_RNA	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1334					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GCGCTGCGAGGTGGACGTAAG	0.488000													41	48					0	0	0.013114	0	0
ZNF536	9745	broad.mit.edu	37	19	31025865	31025865	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:31025865G>A	ENST00000355537.3	+	3	2429	c.2282G>A	c.(2281-2283)cGg>cAg	p.R761Q		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	761					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AAAACTTTCCGGACATCCCAT	0.607000													11	91					0	0	0.010729	0	0
OR5D18	219438	broad.mit.edu	37	11	55587564	55587564	+	Silent	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:55587564A>T	ENST00000333976.4	+	1	479	c.459A>T	c.(457-459)ggA>ggT	p.G153G		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				ATGCCTGGGGAGTCTCATGTT	0.473000													4	132					0	0	0.009096	0	0
LMTK2	22853	broad.mit.edu	37	7	97822452	97822452	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:97822452A>G	ENST00000297293.5	+	11	2968	c.2675A>G	c.(2674-2676)gAg>gGg	p.E892G		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	892					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GAGAGTGAGGAGACCCTGCGA	0.552000													9	22					0	0	0.006214	0	0
KIAA2026	158358	broad.mit.edu	37	9	5921211	5921211	+	Silent	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:5921211T>C	ENST00000399933.3	-	8	4784	c.4785A>G	c.(4783-4785)tcA>tcG	p.S1595S	KIAA2026_ENST00000381461.2_Silent_p.S1565S	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1595										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ATATGTTAATTGATGGTATAG	0.373000													27	41					0	0	0.008361	0	0
SLC14A2	8170	broad.mit.edu	37	18	43204647	43204647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:43204647C>A	ENST00000255226.6	+	2	834	c.18C>A	c.(16-18)agC>agA	p.S6R	SLC14A2_ENST00000586448.1_Missense_Mutation_p.S6R	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	6						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACCCCCACAGCAGTCCTCTCC	0.572000													49	135					3.37225e-12	5.52542e-12	0.014410	1	0
MYH3	4621	broad.mit.edu	37	17	10538233	10538233	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:10538233T>C	ENST00000583535.1	-	31	4367	c.4280A>G	c.(4279-4281)gAg>gGg	p.E1427G	MYH3_ENST00000226209.7_Missense_Mutation_p.E1427G	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1427					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CATCAGATCCTCCACCTCTCC	0.537000													10	42					0	0	0.010729	0	0
C3orf67	200844	broad.mit.edu	37	3	58817568	58817568	+	Silent	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:58817568C>T	ENST00000295966.7	-	13	1769	c.1266G>A	c.(1264-1266)gaG>gaA	p.E422E	RP11-147N17.1_ENST00000463703.1_RNA|C3orf67_ENST00000482387.1_Silent_p.E548E|RP11-147N17.1_ENST00000493123.1_RNA|RP11-147N17.1_ENST00000492031.1_RNA|RP11-147N17.1_ENST00000482372.1_RNA	NM_198463.2	NP_940865.1	Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	428										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		GCATCTGTAACTCGGATTCAC	0.493000													13	27					0	0	0.004007	0	0
NEK3	4752	broad.mit.edu	37	13	52710350	52710350	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:52710350T>C	ENST00000452082.2	-	11	2318	c.1088A>G	c.(1087-1089)cAt>cGt	p.H363R	NEK3_ENST00000339406.3_Missense_Mutation_p.H359R|NEK3_ENST00000400357.2_Missense_Mutation_p.H342R|NEK3_ENST00000378101.2_Missense_Mutation_p.H359R			P51956	NEK3_HUMAN	NIMA-related kinase 3	359					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|stomach(2)	18		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		CTGTCGTCTATGAAGATTTGG	0.403000													8	41					0	0	0.003080	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488814	20488814	+	RNA	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:20488814C>A	ENST00000555186.1	+	0	297					NR_038836.1																						TATGTGGAACCCCCACCTGCT	0.428000													12	44					6.40141e-05	7.651e-05	0.010729	1	0
RP11-125O5.2	0	broad.mit.edu	37	12	21207544	21207544	+	Nonsense_Mutation	SNP	T	T	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:21207544T>G	ENST00000590779.1	+	1	17	c.17T>G	c.(16-18)tTa>tGa	p.L6*	LST3_ENST00000381541.3_Silent_p.L552L|SLCO1B7_ENST00000421593.2_Silent_p.L505L|SLCO1B7_ENST00000554957.1_Silent_p.L552L|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron																							CAGTTGGACTTACCTCATATT	0.353000													10	13					0	0	0.008291	0	0
KIF2B	84643	broad.mit.edu	37	17	51902048	51902048	+	Missense_Mutation	SNP	C	C	A	rs114241810	byFrequency	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:51902048C>A	ENST00000268919.4	+	1	1810	c.1654C>A	c.(1654-1656)Cgt>Agt	p.R552S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	552					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GCCCTACCATCGTGGCCACTA	0.398000													40	55					4.10826e-27	7.54623e-27	0.014410	1	0
AADAT	51166	broad.mit.edu	37	4	170991790	170991790	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:170991790T>C	ENST00000337664.4	-	6	944	c.668A>G	c.(667-669)tAt>tGt	p.Y223C	AADAT_ENST00000353187.2_Missense_Mutation_p.Y223C|AADAT_ENST00000515480.1_Missense_Mutation_p.Y223C|AADAT_ENST00000509167.1_Missense_Mutation_p.Y227C	NM_016228.3	NP_057312.1	Q8N5Z0	AADAT_HUMAN	aminoadipate aminotransferase	223					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|pancreas(1)|stomach(1)	11		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GAGGAAATCATATTTTCTTGC	0.234000													6	26					0	0	0.001984	0	0
ANK3	288	broad.mit.edu	37	10	61836088	61836088	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:61836088G>A	ENST00000280772.1	-	37	4742	c.4551C>T	c.(4549-4551)gcC>gcT	p.A1517A	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1517					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGCCTGACTTGGCTGGCCCAG	0.458000													21	61					0	0	0.008871	0	0
AMELX	265	broad.mit.edu	37	X	11316225	11316225	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:11316225C>G	ENST00000380712.3	+	4	173	c.105C>G	c.(103-105)aaC>aaG	p.N35K	ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000380736.1_Intron|AMELX_ENST00000348912.4_Intron|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000380714.3_Intron|ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380732.3_Intron	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	34					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						TTTTGTAGAACTCACATTCTC	0.358000													8	142					0	0	0.006214	0	0
RHAG	6005	broad.mit.edu	37	6	49578832	49578832	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:49578832G>T	ENST00000371175.4	-	7	998	c.972C>A	c.(970-972)atC>atA	p.I324I	RHAG_ENST00000229810.7_Intron	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	324					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					ATGTATCATGGATCCTCAGTT	0.428000													11	35					1.58986e-06	2.03994e-06	0.008291	1	0
SMG1	23049	broad.mit.edu	37	16	18887484	18887484	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:18887484G>A	ENST00000446231.2	-	13	2264	c.1852C>T	c.(1852-1854)Ctg>Ttg	p.L618L	SMG1_ENST00000389467.3_Silent_p.L618L|SMG1_ENST00000565224.1_Silent_p.L592L			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	618	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ATTGTAGTCAGGGCACTGAGG	0.343000													25	70					0	0	0.018920	0	0
ZNF215	7762	broad.mit.edu	37	11	6977244	6977244	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:6977244G>T	ENST00000278319.5	+	7	1624	c.1036G>T	c.(1036-1038)Gac>Tac	p.D346Y	ZNF215_ENST00000529903.1_Intron|ZNF215_ENST00000414517.2_Missense_Mutation_p.D346Y|ZNF215_ENST00000527171.1_3'UTR	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	346					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		ATTTAATTTAGACTCAGTAGG	0.323000													17	38					1.67942e-08	2.39231e-08	0.006122	1	0
KIAA0226L	80183	broad.mit.edu	37	13	46919590	46919590	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:46919590C>A	ENST00000429979.1	-	13	2381	c.1777G>T	c.(1777-1779)Ggc>Tgc	p.G593C	KIAA0226L_ENST00000534925.1_Missense_Mutation_p.G458C|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.G526C|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.G593C|KIAA0226L_ENST00000378781.3_3'UTR|KIAA0226L_ENST00000378787.3_Intron|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.G436C|KIAA0226L_ENST00000378797.2_Intron|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.G436C	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	593										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						ACCTCACAGCCAGCCACATGT	0.552000													8	11					3.09899e-07	4.11234e-07	0.004482	1	0
WBP11P1	441818	broad.mit.edu	37	18	30091980	30091980	+	RNA	SNP	C	C	T	rs79835848		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:30091980C>T	ENST00000567636.1	+	0	355					NR_003558.1																						TGATCCGAGACATGGAGAAAT	0.408000													10	26					0	0	0.006214	0	0
GPR65	8477	broad.mit.edu	37	14	88477589	88477589	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:88477589T>A	ENST00000267549.3	+	2	956	c.398T>A	c.(397-399)aTg>aAg	p.M133K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	133					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TTTGCACTCATGGTCAGCCTG	0.428000													31	113					0	0	0.013726	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45971330	45971330	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:45971330G>A	ENST00000391621.1	-	1	58	c.12C>T	c.(10-12)tcC>tcT	p.S4S	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron|KRTAP10-2_ENST00000498210.1_5'UTR	NM_198693.2	NP_941966.1	P60368	KR102_HUMAN	keratin associated protein 10-2	4						keratin filament				large_intestine(1)|lung(4)|skin(1)	6						TGGACATGGTGGAGGCGGCCA	0.632000													4	84					0	0	0.001168	0	0
CD200R1	131450	broad.mit.edu	37	3	112643970	112643970	+	Silent	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:112643970G>T	ENST00000471858.1	-	5	1003	c.771C>A	c.(769-771)atC>atA	p.I257I	CD200R1_ENST00000308611.3_Silent_p.I280I|CD200R1_ENST00000295863.4_Intron	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	257					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TGAATCCCACGATGGTCAAAA	0.313000													7	40					1.12685e-05	1.39458e-05	0.004482	1	0
LOC643733	643733	broad.mit.edu	37	11	104778347	104778347	+	RNA	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:104778347T>A	ENST00000532510.1	-	0	1085																											CTTCATATTCTGGAAAAGAGC	0.473000													10	35					0	0	0.008291	0	0
SNRPD3	6634	broad.mit.edu	37	22	24964112	24964112	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr22:24964112G>T	ENST00000215829.3	+	3	874	c.287G>T	c.(286-288)gGc>gTc	p.G96V	SNRPD3_ENST00000402849.1_Missense_Mutation_p.G96V	NM_001278656.1|NM_004175.3	NP_001265585.1|NP_004166.1	P62318	SMD3_HUMAN	small nuclear ribonucleoprotein D3 polypeptide 18kDa	96	Arg/Lys-rich (basic).				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	enzyme binding|histone pre-mRNA DCP binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6						TCAGGGGCTGGCCGAGGAAAA	0.453000													24	30					1.99505e-19	3.58904e-19	0.012213	1	0
CDH5	1003	broad.mit.edu	37	16	66420949	66420949	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:66420949G>A	ENST00000341529.3	+	3	596	c.448G>A	c.(448-450)Gtg>Atg	p.V150M	CDH5_ENST00000563425.2_Missense_Mutation_p.V150M	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	150	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CAACTGGCCTGTGTTCACGCA	0.567000													3	12					0	0	0.004672	0	0
PGK2	5232	broad.mit.edu	37	6	49754451	49754451	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:49754451G>T	ENST00000304801.3	-	1	602	c.450C>A	c.(448-450)ttC>ttA	p.F150L		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	150					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					GTGATGCTCGGAAGGCTTCTA	0.502000													14	50					1.3612e-06	1.75299e-06	0.003163	1	0
CAND1	55832	broad.mit.edu	37	12	67699344	67699344	+	Silent	SNP	G	G	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:67699344G>A	ENST00000545606.1	+	10	2333	c.1896G>A	c.(1894-1896)ttG>ttA	p.L632L		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	632					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TAAAGGCATTGACACTGATTG	0.408000													7	87					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179590742	179590742	+	Silent	SNP	T	T	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:179590742T>A	ENST00000589042.1	-	70	20531	c.20307A>T	c.(20305-20307)atA>atT	p.I6769I	TTN_ENST00000359218.5_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000342992.6_Silent_p.I5525I|TTN_ENST00000591111.1_Silent_p.I6452I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6452	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTTTCTACTATAGGAGGGA	0.388000													13	37					0	0	0.020292	0	0
DMXL1	1657	broad.mit.edu	37	5	118506471	118506471	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:118506471A>T	ENST00000311085.8	+	24	6065	c.5985A>T	c.(5983-5985)aaA>aaT	p.K1995N	DMXL1_ENST00000539542.1_Missense_Mutation_p.K1995N	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1995										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AAACAGATAAAAAGTTGGATG	0.313000													7	22					0	0	0.003080	0	0
MIR519A2	574500	broad.mit.edu	37	19	54265669	54265669	+	RNA	SNP	G	G	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:54265669G>T	ENST00000384990.1	+	0	72					NR_030222.1																						TCCTTTTAGAGTGTTACTGTT	0.423000													13	88					1.5842e-08	2.27525e-08	0.016723	1	0
C9orf50	375759	broad.mit.edu	37	9	132375845	132375845	+	Silent	SNP	G	G	T	rs139948871		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:132375845G>T	ENST00000372478.4	-	5	1113	c.912C>A	c.(910-912)gcC>gcA	p.A304A	NTMT1_ENST00000372486.1_Intron	NM_199350.3	NP_955382.3	Q5SZB4	CI050_HUMAN	chromosome 9 open reading frame 50	304										central_nervous_system(1)|endometrium(4)|large_intestine(2)|ovary(1)|skin(1)|urinary_tract(1)	10		Ovarian(14;0.00556)				CTGGCAGGGCGGCCTTCTGGT	0.627000													16	10					2.39187e-15	4.13249e-15	0.008871	1	0
PCDH1	5097	broad.mit.edu	37	5	141248394	141248394	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:141248394C>A	ENST00000287008.3	-	2	790	c.643G>T	c.(643-645)Gag>Tag	p.E215*	PCDH1_ENST00000456271.1_Intron|PCDH1_ENST00000536585.1_Nonsense_Mutation_p.E193*|PCDH1_ENST00000503492.1_Nonsense_Mutation_p.E215*|PCDH1_ENST00000394536.3_Nonsense_Mutation_p.E215*	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	215	Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CCAAATAGCTCCTGGGCCTCA	0.607000													45	127					4.64027e-19	8.30488e-19	0.014410	1	0
THSD1	55901	broad.mit.edu	37	13	52971719	52971719	+	Silent	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:52971719C>A	ENST00000349258.4	-	3	1213	c.669G>T	c.(667-669)ggG>ggT	p.G223G	THSD1_ENST00000544466.1_Intron|THSD1_ENST00000258613.4_Silent_p.G223G	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	223						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CTGAGTCTCGCCCAAGCAGCT	0.542000													4	26					0.00909568	0.00970762	0.009096	1	0
KIAA1211	57482	broad.mit.edu	37	4	57190412	57190412	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:57190412C>T	ENST00000504228.1	+	8	3626	c.3521C>T	c.(3520-3522)aCt>aTt	p.T1174I	KIAA1211_ENST00000541073.1_Missense_Mutation_p.T1167I|KIAA1211_ENST00000264229.6_Missense_Mutation_p.T1174I			Q6ZU35	K1211_HUMAN	KIAA1211	1174										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AAGGCCAATACTCTTCCTACG	0.498000													13	18					0	0	0.004007	0	0
LAX1	54900	broad.mit.edu	37	1	203740567	203740567	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:203740567A>T	ENST00000442561.2	+	3	662	c.272A>T	c.(271-273)aAt>aTt	p.N91I	LAX1_ENST00000367215.1_3'UTR|LAX1_ENST00000367217.5_Missense_Mutation_p.N75I	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	91					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGAGCCAAAAATATTTATGAC	0.468000													57	298					0	0	0.014410	0	0
CACNA1A	773	broad.mit.edu	37	19	13395964	13395964	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:13395964C>A	ENST00000360228.5	-	21	3609	c.3610G>T	c.(3610-3612)Gag>Tag	p.E1204*	CACNA1A_ENST00000573710.2_Nonsense_Mutation_p.E1205*	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1205	Poly-Glu.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	tcttcctcctcctccttcttc	0.552000													6	24					3.59834e-05	4.37568e-05	0.001168	1	0
STX1B	112755	broad.mit.edu	37	16	31008351	31008351	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:31008351C>A	ENST00000215095.5	-	6	615	c.384G>T	c.(382-384)gaG>gaT	p.E128D	STX1B_ENST00000565419.1_Missense_Mutation_p.E128D	NM_052874.3	NP_443106.1	P61266	STX1B_HUMAN	syntaxin 1B	128					intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(5)	13						CGGTCATTACCTCCACGAACT	0.622000													7	19					1.76689e-08	2.50669e-08	0.006214	1	0
NDUFB5	4711	broad.mit.edu	37	3	179341712	179341712	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:179341712A>G	ENST00000493866.1	+	4	323	c.298A>G	c.(298-300)Aag>Gag	p.K100E	NDUFB5_ENST00000472629.1_Missense_Mutation_p.K140E|NDUFB5_ENST00000259037.3_Missense_Mutation_p.K152E|NDUFB5_ENST00000473500.1_3'UTR	NM_001199957.1	NP_001186886.1	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	152					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|lung(6)|skin(1)	8	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	TTACAGGGTAAAGGAGCTGGA	0.393000													11	112					0	0	0.020292	0	0
RERE	473	broad.mit.edu	37	1	8418524	8418525	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:8418524_8418525insG	ENST00000337907.3	-	21	4704_4705	c.4070_4071insC	c.(4069-4071)cacfs	p.H1357fs	RERE_ENST00000377464.1_Frame_Shift_Ins_p.H1089fs|RERE_ENST00000476556.1_Frame_Shift_Ins_p.H803fs|RERE_ENST00000400908.2_Frame_Shift_Ins_p.H1357fs|RERE_ENST00000400907.2_Intron	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1357					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GCCCGGCGGTCGGGGGGATGGT	0.703													2	4	---	---	---	---					
RP1-159A19.4	0	broad.mit.edu	37	1	27852856	27852857	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:27852856_27852857insG	ENST00000443579.1	+	0	81																											TTTTCTTTGGAGGGGGGGACGG	0.515													3	6	---	---	---	---					
LOC101928460	101928460	broad.mit.edu	37	1	29671660	29671660	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:29671660delG	ENST00000417651.1	-	0	432																											AGCTAGGGGAGGGGCCTCAGG	0.557													2	4	---	---	---	---					
RP11-84A19.4	0	broad.mit.edu	37	1	32332332	32332332	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:32332332delG	ENST00000602889.1	-	0	485																											aagtgaacatgggatgcatgt	0.418													2	4	---	---	---	---					
RP5-884C9.2	0	broad.mit.edu	37	1	38543750	38543750	+	RNA	DEL	T	T	-	rs141538728		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:38543750delT	ENST00000432922.1	+	0	301																											tttttcttccttttttttttt	0.468													2	4	---	---	---	---					
LINC01057	101928079	broad.mit.edu	37	1	95185177	95185178	+	RNA	DEL	AC	AC	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:95185177_95185178delAC	ENST00000452922.1	-	0	506																											CCAACTCTCTACAGGCTCTGAG	0.460													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142638276	142638276	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:142638276delA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							CTGTCATCTGACCCCCCACAC	0.567													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142648461	142648462	+	RNA	INS	-	-	T	rs149586890		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:142648461_142648462insT	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							taatttttgtattttttttttg	0.475													4	3	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142675957	142675957	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:142675957delG	ENST00000369381.2	-	0	2507																											cataccagaagaccaagcagc	0.423													4	3	---	---	---	---					
RP11-640M9.2	0	broad.mit.edu	37	1	144597567	144597568	+	RNA	INS	-	-	A	rs67984124		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:144597567_144597568insA	ENST00000419820.1	+	0	439																											TAAAATCTCTTACAGCTATTAT	0.272													4	3	---	---	---	---					
FAM63A	55793	broad.mit.edu	37	1	150970641	150970644	+	Frame_Shift_Del	DEL	AGTC	AGTC	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:150970641_150970644delAGTC	ENST00000361936.5	-	9	2041_2044	c.1087_1090delGACT	c.(1087-1092)ttfs	p.DF363fs	FAM63A_ENST00000493834.2_Frame_Shift_Del_p.DF268fs|FAM63A_ENST00000361738.6_Frame_Shift_Del_p.DF411fs|FAM63A_ENST00000312210.5_Frame_Shift_Del_p.DF221fs	NM_018379.4	NP_060849.2	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	363							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTCAGGTGAAAGTCAGAGTCACAA	0.554													71	202	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152302092	152302093	+	RNA	DEL	TC	TC	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:152302092_152302093delTC	ENST00000392688.2	+	0	914				FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NR_103778.1																						AGtctctctttctctctctctc	0.436													2	4	---	---	---	---					
LOC400794	400794	broad.mit.edu	37	1	165548530	165548530	+	RNA	DEL	A	A	-	rs145895783		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:165548530delA	ENST00000438275.1	-	0	774				RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000421273.1_RNA																							agagtgagacaaaaaaaaaaa	0.473													2	4	---	---	---	---					
LINC00626	79100	broad.mit.edu	37	1	168760767	168760768	+	RNA	DEL	CA	CA	-	rs72119337		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:168760767_168760768delCA	ENST00000420691.1	+	0	399					NR_024160.1																						CTATCTTTATcacacacacaca	0.470													4	9	---	---	---	---					
LINC00970	101978719	broad.mit.edu	37	1	168946606	168946606	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:168946606delC	ENST00000366408.3	-	0	209																											TCTCCAAGCTcctggctcttc	0.458													2	4	---	---	---	---					
RP5-1011O1.2	0	broad.mit.edu	37	1	192511554	192511554	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:192511554delC	ENST00000434300.1	-	0	71																											tgccaccatgcccagctaatt	0.502													2	4	---	---	---	---					
LOC400800	400800	broad.mit.edu	37	1	199350020	199350021	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:199350020_199350021insC	ENST00000452199.1	+	0	309																											attttttatcacccccagatga	0.351													2	4	---	---	---	---					
HLX-AS1	100873924	broad.mit.edu	37	1	221023125	221023125	+	RNA	DEL	A	A	-	rs34072294		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:221023125delA	ENST00000552026.1	-	0	292																											tttttggaagaatttgaatag	0.318													4	3	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222405266	222405267	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:222405266_222405267insT	ENST00000416510.1	-	0	167																											AAACATGACTATTTTGACATTC	0.361													2	4	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222417657	222417658	+	RNA	INS	-	-	A	rs75967382	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:222417657_222417658insA	ENST00000416510.1	-	0	167																											gaccctgtctcaaaaaaaatta	0.426													3	3	---	---	---	---					
RP11-239E10.3	0	broad.mit.edu	37	1	223355458	223355458	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:223355458delT	ENST00000446145.1	+	0	149																											gagccagggctttcatctcca	0.473													2	4	---	---	---	---					
CTD-2090I13.1	0	broad.mit.edu	37	1	227586615	227586615	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:227586615delA	ENST00000445817.1	+	0	210																											actaaacatcaaaaaaattag	0.517													2	4	---	---	---	---					
LOC101927787	101927787	broad.mit.edu	37	1	234798921	234798921	+	RNA	DEL	C	C	-	rs113432863		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:234798921delC	ENST00000441360.1	+	0	98																											acctcactcacctcacctcac	0.537													6	5	---	---	---	---					
RP11-634B7.4	0	broad.mit.edu	37	1	247806104	247806105	+	RNA	INS	-	-	C	rs138858297	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr1:247806104_247806105insC	ENST00000449298.1	+	0	681				RP11-634B7.4_ENST00000582218.1_RNA																							TACCAACATTATTTGCTTGGAG	0.426													6	2	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	3012678	3012678	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:3012678delA	ENST00000457478.1	-	0	438																											AATTTTCACTAAACATATCAA	0.388													2	4	---	---	---	---					
AC019118.3	0	broad.mit.edu	37	2	3135490	3135491	+	RNA	INS	-	-	G	rs147270613	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:3135490_3135491insG	ENST00000425776.1	-	0	579_580																											CCCTCCGCCCTGGGGGCCGTGT	0.584													2	4	---	---	---	---					
AC016768.1	0	broad.mit.edu	37	2	23245887	23245887	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:23245887delA	ENST00000421581.1	-	0	410																											taataaaactaaaaaaaaaaa	0.448													3	5	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	33943400	33943400	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:33943400delA	ENST00000366209.2	+	0	68																											AGTTGGACTTAAAAAAAAAAA	0.468													2	4	---	---	---	---					
AC006369.2	0	broad.mit.edu	37	2	37854610	37854611	+	RNA	INS	-	-	A	rs143523490	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:37854610_37854611insA	ENST00000419425.1	+	0	313																											AAATACCAATTAAAAAAAAAAT	0.356													2	4	---	---	---	---					
AC009229.5	0	broad.mit.edu	37	2	38463674	38463675	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:38463674_38463675insG	ENST00000450854.1	-	0	533																											gttacctacatgggggggaaaa	0.421													3	3	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40189891	40189891	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:40189891delG	ENST00000418854.1	+	0	132				SLC8A1-AS1_ENST00000599740.1_RNA																							tattggtcaagggtatatctt	0.483													2	4	---	---	---	---					
LRPPRC	10128	broad.mit.edu	37	2	44190820	44190821	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:44190820_44190821insA	ENST00000260665.7	-	12	1451_1452	c.1394_1395insT	c.(1393-1395)acafs	p.T465fs	LRPPRC_ENST00000409659.1_Frame_Shift_Ins_p.T465fs|LRPPRC_ENST00000409946.1_Frame_Shift_Ins_p.T465fs	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	465					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CCAATTCTTGCATTCCTTTGAG	0.356													20	71	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	59203599	59203600	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:59203599_59203600insT	ENST00000452840.1	+	0	815																											ctctctctctctttttttcttt	0.401													2	4	---	---	---	---					
LOC100507073	100507073	broad.mit.edu	37	2	66887745	66887746	+	RNA	INS	-	-	G	rs144053403	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:66887745_66887746insG	ENST00000433396.1	+	0	136																											atgaaatcacttagtgtgtttt	0.381													4	4	---	---	---	---					
AC010987.5	0	broad.mit.edu	37	2	67819217	67819218	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:67819217_67819218insA	ENST00000419809.1	-	0	126																											aaaacacccttaaaaaaaccaa	0.356													2	4	---	---	---	---					
WBP1	23559	broad.mit.edu	37	2	74687542	74687543	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:74687542_74687543insC	ENST00000393972.3	+	5	849_850	c.646_647insC	c.(646-648)cccfs	p.P216fs	WBP1_ENST00000494741.1_3'UTR|WBP1_ENST00000409737.1_Frame_Shift_Ins_p.P179fs|WBP1_ENST00000233615.2_Frame_Shift_Ins_p.P182fs			Q96G27	WBP1_HUMAN	WW domain binding protein 1	182							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						CCACCAGAGTGCCCCCCCTCAT	0.604													7	86	---	---	---	---					
LOC101927948	101927948	broad.mit.edu	37	2	78330725	78330725	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:78330725delT	ENST00000439259.1	+	0	352																											tttggtgcacttttttttttt	0.413													2	4	---	---	---	---					
AC010105.1	0	broad.mit.edu	37	2	82709075	82709076	+	RNA	INS	-	-	AT	rs144399460	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:82709075_82709076insAT	ENST00000437290.2	-	0	204																											gacacaaggtgatatatgttca	0.248													4	2	---	---	---	---					
AC096669.1	0	broad.mit.edu	37	2	108002487	108002488	+	RNA	INS	-	-	CG	rs34398758	byFrequency	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:108002487_108002488insCG	ENST00000422203.2	+	0	374				AC096669.2_ENST00000414300.1_lincRNA																							acacacacacacacacaACAGA	0.426													3	4	---	---	---	---					
NIFK-AS1	254128	broad.mit.edu	37	2	122469230	122469230	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:122469230delA	ENST00000419902.1	+	0	637					NR_037857.1																						caacagagttaaaaaaaaaaa	0.473													2	4	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145608670	145608670	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:145608670delA	ENST00000445791.1	+	0	307					NR_033870.2																						AGAGTGTCATAAGCCAGTGGT	0.353													2	4	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182250495	182250495	+	RNA	DEL	A	A	-	rs112756274		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:182250495delA	ENST00000435411.1	+	0	590																											aatatttaccaaaaaaaaaat	0.318													3	3	---	---	---	---					
LOC101927865	101927865	broad.mit.edu	37	2	208086822	208086823	+	RNA	INS	-	-	A	rs71036908	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:208086822_208086823insA	ENST00000448786.1	-	0	665				AC007879.1_ENST00000435643.1_lincRNA																							ACACTTTCCACAAAAAAAGAAA	0.450													8	3	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208173235	208173235	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:208173235delG	ENST00000412387.1	-	0	315																											tctctgcacagggcaagaaat	0.502													2	4	---	---	---	---					
AC098820.2	0	broad.mit.edu	37	2	217267522	217267522	+	RNA	DEL	T	T	-	rs34142901		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr2:217267522delT	ENST00000457694.1	-	0	272																											ATGCTAATGCTCTTTCCCAAA	0.423													3	4	---	---	---	---					
KIF9-AS1	285352	broad.mit.edu	37	3	47262087	47262087	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:47262087delT	ENST00000429315.3	+	0	329					NR_033373.1																						cattcatctatttttccaccc	0.493													2	4	---	---	---	---					
PRICKLE2-AS1	100652759	broad.mit.edu	37	3	64066305	64066306	+	RNA	INS	-	-	C	rs61258686	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:64066305_64066306insC	ENST00000482609.1	+	0	198				RP11-129B22.2_ENST00000485805.1_lincRNA	NR_045697.1																						CAGCTTTTTTTCCCACATCTTC	0.465													3	5	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64755615	64755615	+	RNA	DEL	G	G	-	rs10709752		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:64755615delG	ENST00000460833.1	+	0	430				ADAMTS9-AS2_ENST00000481312.1_RNA|ADAMTS9-AS2_ENST00000474768.1_RNA																							TGAAAGAGATGGGGGAAACCA	0.438													2	4	---	---	---	---					
LOC101927346	101927346	broad.mit.edu	37	3	74052053	74052054	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:74052053_74052054insT	ENST00000494761.1	+	0	89																											ttctttttttcttttttttttt	0.426													2	4	---	---	---	---					
EPHA6	285220	broad.mit.edu	37	3	96706208	96706208	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:96706208delG	ENST00000389672.5	+	3	523	c.485delG	c.(484-486)agfs	p.R162fs	EPHA6_ENST00000470610.2_Frame_Shift_Del_p.R162fs|EPHA6_ENST00000542517.1_Frame_Shift_Del_p.R68fs	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	67	Ephrin-binding.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GAACATAATAGGCCCATTCAC	0.368													29	62	---	---	---	---					
RP11-200A1.1	0	broad.mit.edu	37	3	134034954	134034957	+	RNA	DEL	TCCG	TCCG	-	rs66630779		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:134034954_134034957delTCCG	ENST00000482019.1	+	0	42																											cattcattcatccgtccattcagt	0.387													3	5	---	---	---	---					
AADACL2-AS1	101928142	broad.mit.edu	37	3	151614330	151614331	+	RNA	INS	-	-	CT	rs147334829	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:151614330_151614331insCT	ENST00000483843.2	-	0	439				RP11-454C18.2_ENST00000475855.1_RNA																							acactctctcactctctctctc	0.356													2	4	---	---	---	---					
RP11-246A10.1	0	broad.mit.edu	37	3	151842543	151842544	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:151842543_151842544insC	ENST00000482382.1	-	0	59																											aaaaaaaaaaaaaagaaatgta	0.490													2	4	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177238022	177238023	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:177238022_177238023insC	ENST00000442937.1	+	0	190					NR_047568.1																						cggtctgtatgcccccctagaa	0.559													2	4	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177289390	177289390	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:177289390delT	ENST00000442937.1	+	0	289					NR_047568.1																						gggtaccaagtttccaactct	0.428													2	4	---	---	---	---					
LOC100507391	100507391	broad.mit.edu	37	3	194443192	194443192	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr3:194443192delG	ENST00000423318.1	+	0	727					NR_037891.1																						acacctttgtgggaatttgaa	0.512													2	4	---	---	---	---					
LOC100129917	100129917	broad.mit.edu	37	4	766287	766288	+	RNA	DEL	TG	TG	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:766287_766288delTG	ENST00000507446.1	-	0	59				RP11-440L14.1_ENST00000503571.1_RNA																							gttttttctttgtgtgtgtgtg	0.495													2	4	---	---	---	---					
STX18-AS1	100507266	broad.mit.edu	37	4	4576600	4576601	+	RNA	DEL	AC	AC	-	rs3839105		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:4576600_4576601delAC	ENST00000502693.1	+	0	357				STX18-AS1_ENST00000512438.1_RNA																							CTTCCTCCCAacacacacacac	0.535													3	6	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14878010	14878010	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:14878010delA	ENST00000505089.1	-	0	111																											tcaaggacctaaaaaaagaac	0.378													2	4	---	---	---	---					
LOC401134	401134	broad.mit.edu	37	4	65830776	65830776	+	RNA	DEL	G	G	-	rs147094992	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:65830776delG	ENST00000509932.1	-	0	239					NR_033976.1																						tttgatggctgcatagtattc	0.383													2	4	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82592303	82592304	+	RNA	DEL	AC	AC	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:82592303_82592304delAC	ENST00000510780.1	-	0	390																											GGTGCTAACAacacacacacac	0.396													3	3	---	---	---	---					
RP11-556I14.2	0	broad.mit.edu	37	4	105789671	105789671	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:105789671delA	ENST00000515127.1	-	0	366																											CAGCATGCTTAAAAAAAAAGA	0.338													2	4	---	---	---	---					
LINC00616	641365	broad.mit.edu	37	4	138978086	138978095	+	RNA	DEL	CTTGCAGGAA	CTTGCAGGAA	-	rs67079742		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:138978086_138978095delCTTGCAGGAA	ENST00000514600.1	-	0	870					NR_037866.1																						GCAGAAAACTCTTGCAGGAACTTGCAGGAA	0.543													2	4	---	---	---	---					
RP11-284M14.1	0	broad.mit.edu	37	4	144039955	144039956	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:144039955_144039956insG	ENST00000507826.1	-	0	354																											GATAGAAAAAAGGGAAGATGTG	0.396													2	4	---	---	---	---					
LOC100506272	100506272	broad.mit.edu	37	4	188464837	188464837	+	RNA	DEL	A	A	-	rs141398371		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:188464837delA	ENST00000515660.1	-	0	258																											atggagttggaagcagtatcc	0.418													4	2	---	---	---	---					
LINC01262	101928971	broad.mit.edu	37	4	190582425	190582426	+	RNA	INS	-	-	G	rs71213139		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr4:190582425_190582426insG	ENST00000513681.1	+	0	664_665																											TGTATCCTTAAGCTTTGAGGCC	0.500													2	4	---	---	---	---					
LINC01340	102546227	broad.mit.edu	37	5	96900005	96900006	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:96900005_96900006insA	ENST00000504012.1	+	0	159																											ttcagacattgaaaaacaaagt	0.406													2	4	---	---	---	---					
LINC01340	102546227	broad.mit.edu	37	5	97005389	97005390	+	RNA	INS	-	-	AG	rs143155647	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:97005389_97005390insAG	ENST00000504012.1	+	0	271																											aggagagtaacgggagaaagtg	0.391													2	4	---	---	---	---					
RP11-492A10.1	0	broad.mit.edu	37	5	113930205	113930206	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:113930205_113930206insA	ENST00000514115.1	-	0	331																											gtgaaagtcccaaaaaactatt	0.431													2	4	---	---	---	---					
CTB-1I21.1	0	broad.mit.edu	37	5	136084622	136084622	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:136084622delT	ENST00000502421.1	+	0	79																											agtttaattatttttttttTC	0.303													2	4	---	---	---	---					
NPY6R	4888	broad.mit.edu	37	5	137146173	137146174	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:137146173_137146174insT	ENST00000510937.1	+	0	2721_2722					NR_002713.3																						tggaggatcacttttgcccagg	0.455													2	4	---	---	---	---					
LOC101926941	101926941	broad.mit.edu	37	5	141870555	141870555	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:141870555delT	ENST00000443800.1	+	0	243				AC005592.2_ENST00000425963.1_RNA																							AAGAGTTCCATTTTTTTTTTA	0.398													2	4	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151510715	151510715	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:151510715delT	ENST00000524295.1	+	0	199																											ATCAAATGCATTTTTAAAATG	0.323													2	4	---	---	---	---					
LOC101927766	101927766	broad.mit.edu	37	5	159272242	159272243	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:159272242_159272243insC	ENST00000522627.1	-	0	3691																											acttttcactgccccctccctg	0.485													2	4	---	---	---	---					
RP11-91H12.4	0	broad.mit.edu	37	5	175336357	175336357	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr5:175336357delC	ENST00000502813.1	-	0	87																											cccaaagcttccagtgacttc	0.557													2	4	---	---	---	---					
RP11-686D16.1	0	broad.mit.edu	37	6	19321242	19321242	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:19321242delA	ENST00000443504.1	-	0	10																											TACTTATTGCAAAAGCAGTTC	0.353													2	4	---	---	---	---					
RP1-209A6.1	0	broad.mit.edu	37	6	22756461	22756462	+	RNA	INS	-	-	A	rs5874888	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:22756461_22756462insA	ENST00000420572.2	-	0	197																											TTTCTGCAATGATGCATTCCCT	0.431													4	3	---	---	---	---					
CMAHP	8418	broad.mit.edu	37	6	25118798	25118799	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:25118798_25118799insT	ENST00000377989.4	-	0	724																				NS(1)	1						catatttaaaatttttgttgcc	0.332													2	4	---	---	---	---					
GUSBP2	387036	broad.mit.edu	37	6	26857093	26857093	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:26857093delT	ENST00000463434.1	-	0	94																											TGCttttttcttttttttttt	0.493													3	6	---	---	---	---					
HCG9	10255	broad.mit.edu	37	6	29945375	29945376	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:29945375_29945376insT	ENST00000376800.3	+	0	406																											TTTACCAAAGCTTTTTTTTCTC	0.322													2	4	---	---	---	---					
LINC00243	401247	broad.mit.edu	37	6	30798144	30798145	+	RNA	DEL	TG	TG	-	rs34860577		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:30798144_30798145delTG	ENST00000399196.1	-	0	145																											TCCCCACTGTTGTGTGTGTGGG	0.535													4	3	---	---	---	---					
CLIC1	1192	broad.mit.edu	37	6	31701701	31701702	+	Frame_Shift_Ins	INS	-	-	C	rs1049227		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:31701701_31701702insC	ENST00000375780.2	-	4	758_759	c.186_187insG	c.(184-189)ggagctfs	p.A63fs	CLIC1_ENST00000375784.3_Frame_Shift_Ins_p.A63fs|CLIC1_ENST00000395892.1_Frame_Shift_Ins_p.A63fs|CLIC1_ENST00000375779.2_Frame_Shift_Ins_p.A63fs			O00299	CLIC1_HUMAN	chloride intracellular channel 1	63	Required for insertion into the membrane.			Q -> E (in Ref. 1; AAC25675 and 3; AAD26137).	signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)|skin(1)	7						AATGGGAGCTGCCCCCCTGGGC	0.564													7	207	---	---	---	---					
LOC101928516	101928516	broad.mit.edu	37	6	75147812	75147812	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:75147812delA	ENST00000435946.1	+	0	193																											GAGACTTCTCATTTACCTTTT	0.458													2	4	---	---	---	---					
TARID	100507308	broad.mit.edu	37	6	134032763	134032763	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:134032763delC	ENST00000607033.1	-	0	623				RP3-323P13.2_ENST00000606544.1_RNA|RP3-323P13.2_ENST00000606292.1_RNA|RP3-323P13.2_ENST00000607573.1_RNA																							ctccccatttcccccctcagc	0.373													2	4	---	---	---	---					
RP3-466P17.1	0	broad.mit.edu	37	6	146058257	146058258	+	RNA	DEL	TC	TC	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr6:146058257_146058258delTC	ENST00000603994.1	+	0	1552_1553				RP3-466P17.2_ENST00000603042.1_lincRNA																							GTTGTGTGCTTCCCAAATGGCA	0.470													2	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34613631	34613631	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:34613631delT	ENST00000419766.1	-	0	160					NR_033664.1|NR_033665.1																						TATGAAGCAATTTTTTCCCCT	0.383													2	4	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72048663	72048664	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:72048663_72048664insA	ENST00000438125.1	-	0	1399							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										CAACCTCAGCCAAAAAATGTAG	0.401													2	4	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72195695	72195696	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:72195695_72195696insA	ENST00000438125.1	-	0	696							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										ggaggcgtaggaaaaaaagcct	0.450													2	4	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100366360	100366360	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:100366360delG	ENST00000542585.1	+	0	5301				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGGGGGTCAGGGGAGCCAGG	0.647													2	4	---	---	---	---					
RELN	5649	broad.mit.edu	37	7	103629671	103629671	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:103629671delC	ENST00000424685.2	-	1	292	c.133delG	c.(133-135)agfs	p.E45fs	RELN_ENST00000428762.1_Frame_Shift_Del_p.E45fs|RELN_ENST00000343529.5_Frame_Shift_Del_p.E45fs			P78509	RELN_HUMAN	reelin	45	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCTTCCAGCTCCCCGTGGTGG	0.627													12	47	---	---	---	---					
RP5-921G16.1	0	broad.mit.edu	37	7	123719980	123719980	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:123719980delT	ENST00000484322.1	+	0	168																											ctgctgcttcttttttttttg	0.398													2	4	---	---	---	---					
C7orf13	129790	broad.mit.edu	37	7	156307047	156307048	+	RNA	INS	-	-	GG	rs112661643	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr7:156307047_156307048insGG	ENST00000447933.1	-	0	300																											aagctATGGGTGTGTGTGTGTG	0.475													2	4	---	---	---	---					
RP11-459E5.1	0	broad.mit.edu	37	8	22551580	22551581	+	RNA	INS	-	-	GG			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:22551580_22551581insGG	ENST00000523627.1	+	0	164																											CGCGCAGGGTTGGGGGGGTGTT	0.589													2	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	64862611	64862612	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:64862611_64862612insC	ENST00000524360.1	-	0	195				RP11-32K4.1_ENST00000521958.1_RNA|RP11-32K4.1_ENST00000523191.1_RNA																							ACTGATTCTGACCCCCCCATAA	0.332													2	4	---	---	---	---					
LINC01111	101926978	broad.mit.edu	37	8	77408080	77408080	+	RNA	DEL	T	T	-	rs34551593		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:77408080delT	ENST00000518732.1	+	0	332				ZFHX4-AS1_ENST00000522961.1_RNA																							ctactcctgcttttttttttt	0.289													2	4	---	---	---	---					
LOC101927040	101927040	broad.mit.edu	37	8	80717757	80717757	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:80717757delA	ENST00000502766.2	-	0	349																											ctatgaggttaaaaaaaaagg	0.398													2	4	---	---	---	---					
RP11-122C21.1	0	broad.mit.edu	37	8	92678274	92678274	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:92678274delA	ENST00000518416.1	-	0	415																											AGTAATTTTTAAGGATATGCA	0.299													4	3	---	---	---	---					
FLJ46284	441369	broad.mit.edu	37	8	93776922	93776923	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:93776922_93776923insA	ENST00000504861.2	-	0	140				RP11-100L22.2_ENST00000521148.1_RNA	NR_046114.1																						acagaattgagaaaaaaaaaaa	0.356													3	4	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	109989327	109989327	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:109989327delT	ENST00000522244.1	-	0	264																											GTCCAAGGAATTTGGGAAATA	0.403													2	4	---	---	---	---					
RP11-3G20.1	0	broad.mit.edu	37	8	122684145	122684146	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:122684145_122684146insA	ENST00000518922.1	-	0	280_281																											AGGCTTTCTTCAAAAACGGAAA	0.416													2	4	---	---	---	---					
RP11-89K10.1	0	broad.mit.edu	37	8	127628733	127628736	+	RNA	DEL	TCCT	TCCT	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:127628733_127628736delTCCT	ENST00000519880.1	+	0	156				RP11-89K10.1_ENST00000517915.1_RNA|RP11-89K10.1_ENST00000520512.1_RNA|RP11-89K10.1_ENST00000517773.1_RNA																							tttccttccctccttccttccttc	0.373													4	5	---	---	---	---					
CASC8	727677	broad.mit.edu	37	8	128465856	128465858	+	RNA	DEL	AAG	AAG	-	rs60735771		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:128465856_128465858delAAG	ENST00000502082.1	-	0	1041				CASC8_ENST00000502056.1_RNA																							AAAAAAAAAAAAGCGTACTCCCA	0.365													2	4	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	138955940	138955941	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:138955940_138955941insT	ENST00000518973.1	-	0	514																											TCCCAGAACTGTTTTTGAATGG	0.490													2	4	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	139043525	139043526	+	RNA	DEL	AT	AT	-	rs149929011		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:139043525_139043526delAT	ENST00000518973.1	-	0	514																											atacatatacatatatatatac	0.257													2	4	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142477454	142477463	+	RNA	DEL	CCTGGCCCTT	CCTGGCCCTT	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr8:142477454_142477463delCCTGGCCCTT	ENST00000430863.1	-	0	2403					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CCCTCCGCCCcctggcccttcctggccctt	0.671													5	8	---	---	---	---					
LOC101928438	101928438	broad.mit.edu	37	9	102483511	102483512	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:102483511_102483512insA	ENST00000427039.1	-	0	190																											acaccacatccaaaaaaaccca	0.347													2	4	---	---	---	---					
RP11-308N19.1	0	broad.mit.edu	37	9	109084026	109084027	+	RNA	INS	-	-	T	rs151143116	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:109084026_109084027insT	ENST00000435485.1	+	0	171																											CTGGAAGCACATTTTTTTTTAA	0.401													3	3	---	---	---	---					
RP11-343J18.2	0	broad.mit.edu	37	9	128887448	128887448	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr9:128887448delA	ENST00000441473.1	+	0	235																											ccattattggaacgctaagca	0.473													2	4	---	---	---	---					
ZNF32-AS3	414201	broad.mit.edu	37	10	44131796	44131797	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:44131796_44131797insT	ENST00000458063.1	+	0	162					NR_038867.1																						tgatcatgtggtttttgtcttt	0.332													2	4	---	---	---	---					
LINC00842	643650	broad.mit.edu	37	10	47147408	47147409	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:47147408_47147409insC	ENST00000422732.2	-	0	435					NR_033957.1																						aaacaaaacaacccccccaaac	0.406													2	4	---	---	---	---					
ZNF503	84858	broad.mit.edu	37	10	77040314	77040315	+	RNA	DEL	GT	GT	-	rs72205518		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:77040314_77040315delGT	ENST00000418818.2	-	0	253																											gtgtgtatgcgtgtgtgtgtgt	0.460													3	5	---	---	---	---					
LINC01520	101929684	broad.mit.edu	37	10	87226375	87226376	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:87226375_87226376insA	ENST00000441457.1	+	0	1208																											ataaaaagatgaaaaaaagatg	0.332													2	4	---	---	---	---					
RP11-452K12.7	0	broad.mit.edu	37	10	99174805	99174805	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr10:99174805delA	ENST00000422848.1	+	0	259																											accttatctcaaaaaaaaaaa	0.488													4	7	---	---	---	---					
RP11-98J9.1	0	broad.mit.edu	37	11	13828708	13828709	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:13828708_13828709insG	ENST00000531749.1	+	0	188																											ggggtgaggaagggggagggag	0.416													2	4	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14253352	14253352	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:14253352delA	ENST00000310358.7	+	0	1360							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGCAATGTCTAAAAAAAAAAG	0.294													3	3	---	---	---	---					
RP11-396O20.1	0	broad.mit.edu	37	11	15683166	15683166	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:15683166delC	ENST00000532242.1	+	0	151																											CTCTAACTTTCCCCCAGGACT	0.507													2	4	---	---	---	---					
PLEKHA7	144100	broad.mit.edu	37	11	16876505	16876505	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:16876505delC	ENST00000355661.3	-	6	463	c.453delG	c.(451-453)ggfs	p.G151fs	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Frame_Shift_Del_p.G151fs|PLEKHA7_ENST00000448080.2_Frame_Shift_Del_p.G151fs			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	151					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GGTCTCTCTTCCCAAAGCTGT	0.493													24	97	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28856739	28856740	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:28856739_28856740insG	ENST00000513853.1	+	0	304																											ACgttgggggagggggggaata	0.450													2	4	---	---	---	---					
PAMR1	25891	broad.mit.edu	37	11	35492305	35492305	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:35492305delC	ENST00000378880.2	-	5	1001	c.556delG	c.(556-558)atfs	p.D186fs	PAMR1_ENST00000534803.1_5'UTR|PAMR1_ENST00000378878.3_Intron|PAMR1_ENST00000278360.3_Frame_Shift_Del_p.D186fs|PAMR1_ENST00000532848.1_Frame_Shift_Del_p.D146fs	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	186	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						TTGTCTCCATCACGAACCTCA	0.547													12	35	---	---	---	---					
C11orf97	643037	broad.mit.edu	37	11	94246111	94246112	+	RNA	DEL	AC	AC	-	rs72198400		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:94246111_94246112delAC	ENST00000542198.1	+	0	93																											AAAGGAATTAacacacacacac	0.386													4	3	---	---	---	---					
RP11-108O10.2	0	broad.mit.edu	37	11	111643970	111643970	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:111643970delT	ENST00000529841.1	-	0	131																											CAATGGTAGAttttttttttg	0.468													3	6	---	---	---	---					
USP2-AS1	100499227	broad.mit.edu	37	11	119266396	119266397	+	RNA	INS	-	-	T	rs111269978	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:119266396_119266397insT	ENST00000498979.2	+	0	273				USP2-AS1_ENST00000500970.1_RNA|USP2-AS1_ENST00000578923.1_RNA|USP2-AS1_ENST00000577297.1_RNA|USP2-AS1_ENST00000530002.1_RNA	NR_034160.1																						acacccagctattttttttttc	0.505													2	4	---	---	---	---					
LOC283177	283177	broad.mit.edu	37	11	134343532	134343533	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr11:134343532_134343533insC	ENST00000528482.2	+	0	1554																											tctttgggatgccccccgccct	0.554													2	4	---	---	---	---					
RP11-1038A11.3	0	broad.mit.edu	37	12	5475204	5475204	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:5475204delT	ENST00000537192.1	+	0	219																											gcacaaagagtttttTTTTTA	0.353													2	4	---	---	---	---					
LOC102724050	102724050	broad.mit.edu	37	12	54819418	54819418	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:54819418delT	ENST00000550474.1	+	0	47				RP11-753H16.5_ENST00000552785.1_RNA																							gggtaccctcttccagtctct	0.493													2	4	---	---	---	---					
RP11-981P6.1	0	broad.mit.edu	37	12	89970358	89970358	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:89970358delA	ENST00000552778.1	+	0	147																											AATTGTTCATATGGGGGATTC	0.418													2	4	---	---	---	---					
RP11-497G19.3	0	broad.mit.edu	37	12	117037684	117037685	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:117037684_117037685insC	ENST00000550742.1	+	0	398																											TCTTGGGTCCTCCCCCCACCTC	0.599											OREG0022159	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
ZNF664-FAM101A	100533183	broad.mit.edu	37	12	124577355	124577356	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:124577355_124577356insG	ENST00000540762.1	+	0	247																											atgatgatggtgtgatgatgat	0.436													2	4	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124846815	124846816	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr12:124846815_124846816insG	ENST00000356219.3	-	23	3108_3109	c.2953_2954insC	c.(2953-2955)ggafs	p.G985fs	NCOR2_ENST00000397355.1_Frame_Shift_Ins_p.G969fs|NCOR2_ENST00000429285.2_Frame_Shift_Ins_p.G968fs|NCOR2_ENST00000405201.1_Frame_Shift_Ins_p.G986fs|NCOR2_ENST00000404621.1_Frame_Shift_Ins_p.G968fs|NCOR2_ENST00000404121.2_Frame_Shift_Ins_p.G539fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	986					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGCGTCCTCCCGGGGGGGCTCA	0.653													2	4	---	---	---	---					
GJB6	10804	broad.mit.edu	37	13	20797249	20797249	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:20797249delT	ENST00000356192.6	-	5	991	c.371delA	c.(370-372)cgfs	p.Q124fs	GJB6_ENST00000400066.3_Frame_Shift_Del_p.Q124fs|GJB6_ENST00000400065.3_Frame_Shift_Del_p.Q124fs|GJB6_ENST00000241124.6_Frame_Shift_Del_p.Q124fs	NM_001110219.2	NP_001103689.1	O95452	CXB6_HUMAN	gap junction protein, beta 6, 30kDa	124				Q -> H (in Ref. 1; CAA06611).	cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	9		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		CCGAACCTTCTGCTTTTTAAT	0.468													20	63	---	---	---	---					
LINC00457	100874179	broad.mit.edu	37	13	35033467	35033467	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:35033467delA	ENST00000605909.1	+	0	170																											ATATTTTTGGAAAGCCCTTAT	0.318													2	4	---	---	---	---					
RP11-321C24.1	0	broad.mit.edu	37	13	45620804	45620805	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:45620804_45620805insT	ENST00000437748.2	-	0	159_160																											TGCTTCTCAGGTTTTTCCGCCA	0.470													2	4	---	---	---	---					
RNASEH2B-AS1	100874255	broad.mit.edu	37	13	51462614	51462614	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:51462614delT	ENST00000596992.1	-	0	382				RNASEH2B-AS1_ENST00000594244.1_RNA|RNASEH2B-AS1_ENST00000593750.1_RNA|RNASEH2B-AS1_ENST00000454605.1_RNA|RNASEH2B-AS1_ENST00000601286.1_RNA|RNASEH2B-AS1_ENST00000593369.1_RNA																							GAATACACTATTTGGTTTCCC	0.348													2	4	---	---	---	---					
GUCY1B2	2974	broad.mit.edu	37	13	51589121	51589122	+	RNA	DEL	CA	CA	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:51589121_51589122delCA	ENST00000493639.2	-	0	1729					NR_003923.2																						tacacacatgcacacacacaca	0.386													3	3	---	---	---	---					
LINC00558	100861552	broad.mit.edu	37	13	54432786	54432786	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:54432786delC	ENST00000569422.1	+	0	432					NR_047488.1																						CTCAAACTTGCCCTACTACCT	0.393													2	4	---	---	---	---					
RP11-223F20.2	0	broad.mit.edu	37	13	66444037	66444037	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:66444037delG	ENST00000437777.1	+	0	70																											cacccaggctggagagcagtg	0.423													2	4	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101551039	101551040	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr13:101551039_101551040insT	ENST00000457843.1	+	0	141					NR_047687.1																						AATTATAGGAATTTTTTTTTCC	0.356													2	4	---	---	---	---					
RP11-355I22.2	0	broad.mit.edu	37	14	62573320	62573320	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:62573320delT	ENST00000554252.1	-	0	228																											GCCTGTCTTCTTCCACTTTGG	0.363													2	4	---	---	---	---					
LINC01269	103695436	broad.mit.edu	37	14	71174167	71174168	+	RNA	INS	-	-	G	rs146667061	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:71174167_71174168insG	ENST00000553682.1	+	0	458																											AGGCCACAGCTGGGGGGGCAGG	0.545													3	4	---	---	---	---					
RP6-114E22.1	0	broad.mit.edu	37	14	72322071	72322071	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:72322071delG	ENST00000555581.1	+	0	131																											tctggggaatggacatattgg	0.294													2	4	---	---	---	---					
RP3-514A23.2	0	broad.mit.edu	37	14	73045925	73045926	+	RNA	INS	-	-	GGA	rs145725826	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:73045925_73045926insGGA	ENST00000555303.1	-	0	451																											CACAAGGAATCGGAGAACAAGG	0.495													3	4	---	---	---	---					
RP1-240K6.3	0	broad.mit.edu	37	14	73943355	73943355	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:73943355delT	ENST00000515412.2	+	0	486																											AAGGGTTCAGTTAGGCTCTCT	0.483													2	4	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82490719	82490719	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr14:82490719delA	ENST00000554814.1	+	0	315																											tatacccagtaatggaattgc	0.363													2	4	---	---	---	---					
LOC100128714	100128714	broad.mit.edu	37	15	26166325	26166326	+	RNA	DEL	AC	AC	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:26166325_26166326delAC	ENST00000383019.2	+	0	207					NR_040082.1																						ggtattaaagacacacacacag	0.460													2	4	---	---	---	---					
LINC00927	283688	broad.mit.edu	37	15	80620779	80620780	+	RNA	INS	-	-	G	rs138883962	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:80620779_80620780insG	ENST00000558913.1	-	0	213					NR_033833.1																						AGGGGTGCCATGGGGGGGAAGA	0.554													2	4	---	---	---	---					
RP11-276M12.1	0	broad.mit.edu	37	15	82282388	82282388	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr15:82282388delT	ENST00000559299.1	-	0	240																											aacttattcattttattatga	0.358													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5925245	5925245	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:5925245delA	ENST00000569895.1	+	0	436																											tgttacagacaaaaaaactga	0.423													2	4	---	---	---	---					
RP11-67H24.2	0	broad.mit.edu	37	16	32828380	32828381	+	RNA	INS	-	-	T	rs148268914	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:32828380_32828381insT	ENST00000569859.1	+	0	373																											agcatctgtggtttgttaggtc	0.337													3	5	---	---	---	---					
RP11-467L24.1	0	broad.mit.edu	37	16	64511545	64511546	+	RNA	DEL	CA	CA	-	rs74264159		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:64511545_64511546delCA	ENST00000564046.1	+	0	243																											CTCTCTCTCTcacacacacaca	0.480													3	4	---	---	---	---					
LINC00922	283867	broad.mit.edu	37	16	65508716	65508717	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:65508716_65508717insG	ENST00000569736.1	-	0	217					NR_027755.1																						AGAGTTATTATGGGGGGGTGCT	0.455													2	4	---	---	---	---					
AC009120.6	0	broad.mit.edu	37	16	74349703	74349703	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr16:74349703delC	ENST00000565313.1	-	0	47				AC009120.6_ENST00000561921.1_RNA																							ttctttcctacctttttttaa	0.373													2	4	---	---	---	---					
CCDC144NL-AS1	440416	broad.mit.edu	37	17	20846129	20846129	+	RNA	DEL	G	G	-	rs71160106		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:20846129delG	ENST00000582583.1	+	0	123				RP11-344E13.3_ENST00000423473.2_RNA|RP11-344E13.3_ENST00000437829.1_RNA|RP11-344E13.3_ENST00000580056.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA|RP11-344E13.3_ENST00000433763.2_RNA|RP11-344E13.3_ENST00000583481.1_RNA																							gtcctgcactgggggaaaaag	0.363													3	3	---	---	---	---					
LOC100505782	100505782	broad.mit.edu	37	17	39571232	39571232	+	RNA	DEL	A	A	-	rs34649891		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:39571232delA	ENST00000432258.1	+	0	2194																											cctgggtgacaaaAAAAAAAA	0.507													2	4	---	---	---	---					
RP11-429O1.1	0	broad.mit.edu	37	17	50593940	50593940	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:50593940delA	ENST00000572848.1	+	0	76																											TATGACTCCTAGAGAAATTAC	0.458													2	4	---	---	---	---					
CASC17	101928165	broad.mit.edu	37	17	69153033	69153033	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:69153033delG	ENST00000569074.1	-	0	134																											aagccaatatgattatttaaa	0.294													2	4	---	---	---	---					
CASC17	101928165	broad.mit.edu	37	17	69169970	69169971	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:69169970_69169971insC	ENST00000569074.1	-	0	134																											TTAAATGATATCCCCGTGCTGA	0.386													2	4	---	---	---	---					
MRPS7	51081	broad.mit.edu	37	17	73258564	73258565	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr17:73258564_73258565insC	ENST00000579002.1	+	1	572_573	c.157_158insC	c.(157-159)cccfs	p.P53fs	MRPS7_ENST00000579761.1_Intron|MRPS7_ENST00000245539.6_Intron			Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7	0					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)	6	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CCTCCTCCTTTCCCCCCCTCCC	0.554													7	184	---	---	---	---					
KC6	641516	broad.mit.edu	37	18	39067810	39067810	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:39067810delA	ENST00000592302.1	-	0	507					NR_002838.1																						tgtaatgtttacctccctgtg	0.473													4	5	---	---	---	---					
LOC643542	643542	broad.mit.edu	37	18	65456231	65456231	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:65456231delC	ENST00000583687.1	+	0	204					NR_033921.1																						TTCTGTCCTGCCCTGGGCCAC	0.607													2	4	---	---	---	---					
RP11-421N8.2	0	broad.mit.edu	37	18	65930817	65930818	+	RNA	INS	-	-	C			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr18:65930817_65930818insC	ENST00000581844.1	-	0	46_47																											tgtgctttcctcccccacacct	0.505													2	4	---	---	---	---					
CTC-459F4.5	0	broad.mit.edu	37	19	28363509	28363509	+	RNA	DEL	G	G	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:28363509delG	ENST00000589471.1	-	0	118																											tgatgatggtgatgatgatga	0.403													2	4	---	---	---	---					
CTC-439O9.3	0	broad.mit.edu	37	19	31682501	31682502	+	RNA	INS	-	-	T			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:31682501_31682502insT	ENST00000589511.1	+	0	223																											tataaaagacatttttaatttc	0.436													2	4	---	---	---	---					
LOC400684	400684	broad.mit.edu	37	19	32882998	32882998	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr19:32882998delA	ENST00000592680.1	-	0	667					NR_046201.1																						agagaaagagaaaaaaaaaaa	0.498													2	4	---	---	---	---					
TGM3	7053	broad.mit.edu	37	20	2298023	2298023	+	Frame_Shift_Del	DEL	G	G	-	rs146568830	by1000genomes	TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:2298023delG	ENST00000381458.5	+	7	938	c.875delG	c.(874-876)cgfs	p.R292fs	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	292					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	ATTCCTTCCCGGGTGATCACC	0.567													27	96	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29585451	29585452	+	RNA	INS	-	-	C	rs73605368		TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:29585451_29585452insC	ENST00000432067.1	-	0	152																											ATCAACCATTTCCCATGTCCCT	0.421													4	3	---	---	---	---					
C20orf112	140688	broad.mit.edu	37	20	31041555	31041556	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr20:31041555_31041556insG	ENST00000359676.5	-	4	538_539	c.396_397insC	c.(394-399)ccacagfs	p.Q133fs	C20orf112_ENST00000475781.1_5'UTR	NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	133										endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						CCAGAGCTGTAGGGGGGGGACT	0.634													3	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11096512	11096516	+	RNA	DEL	GTTTT	GTTTT	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:11096512_11096516delGTTTT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccATTTTTAAgttttgttttgtttt	0.493													4	2	---	---	---	---					
AP001347.6	0	broad.mit.edu	37	21	15405594	15405595	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:15405594_15405595insA	ENST00000428809.1	+	0	177																											TATTTCATATGTCATTAGAAAA	0.391													2	4	---	---	---	---					
AP000476.1	0	broad.mit.edu	37	21	25806085	25806088	+	RNA	DEL	AAAT	AAAT	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:25806085_25806088delAAAT	ENST00000453784.2	+	0	165																											tccctaccaaaaataaataaataa	0.412													2	4	---	---	---	---					
LOC339622	339622	broad.mit.edu	37	21	26410160	26410161	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:26410160_26410161insA	ENST00000441009.1	+	0	406					NR_046198.3																						TAAATTACACCAAAAACATTTG	0.431													2	4	---	---	---	---					
BACH1	571	broad.mit.edu	37	21	30730426	30730426	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:30730426delA	ENST00000504298.1	+	0	265					NR_027655.1																						GGGGAGAAGGAGGGCCCCTGG	0.532													2	4	---	---	---	---					
AP000318.2	0	broad.mit.edu	37	21	35604133	35604134	+	RNA	INS	-	-	G			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr21:35604133_35604134insG	ENST00000427022.1	+	0	311																											AGTAAAATGTTGGGGGGCAGgg	0.530													2	4	---	---	---	---					
RFPL1S	10740	broad.mit.edu	37	22	29846987	29846988	+	RNA	INS	-	-	A			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chr22:29846987_29846988insA	ENST00000461286.2	-	0	258					NR_002727.2																						gatcctgtctcaaaaaaaaaTT	0.475													3	3	---	---	---	---					
CA5BP1	340591	broad.mit.edu	37	X	15710376	15710376	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:15710376delT	ENST00000380334.2	+	0	225																											Cttttttttcttttttttttt	0.403													3	3	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22639040	22639040	+	RNA	DEL	C	C	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:22639040delC	ENST00000455399.1	-	0	312																											CTCATACCTACCACAGTATCT	0.443													2	4	---	---	---	---					
RP1-154K9.2	0	broad.mit.edu	37	X	42536319	42536319	+	RNA	DEL	A	A	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:42536319delA	ENST00000411879.1	+	0	676																											agctttggacaaaaaaacctg	0.443													2	4	---	---	---	---					
GS1-256O22.5	0	broad.mit.edu	37	X	142469806	142469806	+	RNA	DEL	T	T	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:142469806delT	ENST00000431432.1	+	0	176																											gctgaaggactttttggccaa	0.358													2	4	---	---	---	---					
GS1-256O22.5	0	broad.mit.edu	37	X	142552752	142552753	+	RNA	DEL	GT	GT	-			TCGA-17-Z025-01A-01W-0746-08	TCGA-17-Z025-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99eab29e-32d3-49d5-aa30-56de8be556e7	e77e7ede-a75b-457f-a132-7120368a422b	g.chrX:142552752_142552753delGT	ENST00000431432.1	+	0	268																											AAGATTAAGAGTGTGTGTGTGT	0.347													3	3	---	---	---	---					
