Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ASPM	259266	broad.mit.edu	37	1	197057474	197057474	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:197057474C>T	ENST00000367409.4	-	26	10329	c.10073G>A	c.(10072-10074)gGt>gAt	p.G3358D	ASPM_ENST00000294732.7_Missense_Mutation_p.G1773D|ASPM_ENST00000367408.1_Missense_Mutation_p.G1023D	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3358					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						AACTTTATTACCAGGCTTTTC	0.338000													53	3					0	0	0.139131	0	0
OR9A4	130075	broad.mit.edu	37	7	141618909	141618909	+	Silent	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:141618909C>T	ENST00000548136.1	+	1	293	c.234C>T	c.(232-234)ccC>ccT	p.P78P	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TAATCGTCCCCGTGATGCTTT	0.512000													64	75					0	0	0.139131	0	0
ZNF16	7564	broad.mit.edu	37	8	146156779	146156779	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:146156779A>T	ENST00000276816.4	-	4	1580	c.1394T>A	c.(1393-1395)gTa>gAa	p.V465E	ZNF16_ENST00000394909.2_Missense_Mutation_p.V465E	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TTTTCCACATACATTACACAC	0.488000													12	334					0	0	0.119110	0	0
FAM47B	170062	broad.mit.edu	37	X	34961912	34961912	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:34961912G>A	ENST00000329357.5	+	1	1000	c.964G>A	c.(964-966)Gag>Aag	p.E322K		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	322	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCTCTGCCCGGAGCCTCCCGA	0.587000													9	125					0	0	0.069234	0	0
TF	7018	broad.mit.edu	37	3	133473427	133473427	+	Silent	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:133473427C>T	ENST00000402696.3	+	4	899	c.414C>T	c.(412-414)caC>caT	p.H138H	TF_ENST00000264998.3_Silent_p.H11H|TF_ENST00000475382.1_3'UTR	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	138	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	AGTCCTGCCACACGGGTCTAG	0.512000													7	309					0	0	0.058154	0	0
MUC17	140453	broad.mit.edu	37	7	100683474	100683474	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:100683474T>G	ENST00000306151.4	+	3	8841	c.8777T>G	c.(8776-8778)gTa>gGa	p.V2926G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2926	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTAGTGAAGTAAGTACTCCA	0.493000													5	68					0	0	0.029380	0	0
CCDC28A	25901	broad.mit.edu	37	6	139106442	139106442	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:139106442A>C	ENST00000332797.6	+	4	826	c.671A>C	c.(670-672)tAt>tCt	p.Y224S		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	224										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TTGGAGCTCTATGGGGAGTTA	0.413000													55	101					0	0	0.139131	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													9	31					0	0	0.058154	0	0
KHDRBS3	10656	broad.mit.edu	37	8	136594172	136594172	+	Silent	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:136594172G>T	ENST00000355849.5	+	6	1073	c.663G>T	c.(661-663)ggG>ggT	p.G221G	KHDRBS3_ENST00000520981.1_Intron	NM_006558.1	NP_006549.1	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal transduction associated 3	221	Interaction with SIAH1.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	26	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			TACCACGAGGGACGCCAACTC	0.552000													54	35					3.31993e-32	4.30081e-32	0.139131	1	0
OR2T3	343173	broad.mit.edu	37	1	248637451	248637451	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:248637451C>A	ENST00000359594.2	+	1	825	c.800C>A	c.(799-801)cCg>cAg	p.P267Q		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TACATGCTCCCGAGTTCCTAC	0.542000													6	549					6.40141e-05	7.10806e-05	0.080935	1	0
MYH15	22989	broad.mit.edu	37	3	108112888	108112888	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:108112888G>T	ENST00000273353.3	-	37	5365	c.5309C>A	c.(5308-5310)gCa>gAa	p.A1770E		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1770						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTCAATGGCTGCCTTCTTGGC	0.547000													112	48					6.83383e-50	9.12957e-50	0.139131	1	0
GDNF	2668	broad.mit.edu	37	5	37815776	37815776	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:37815776C>T	ENST00000326524.2	-	3	812	c.613G>A	c.(613-615)Gct>Act	p.A205T	GDNF_ENST00000381826.4_Missense_Mutation_p.A196T|GDNF_ENST00000515058.1_Missense_Mutation_p.A179T|GDNF_ENST00000427982.1_Missense_Mutation_p.A222T|GDNF_ENST00000344622.4_Missense_Mutation_p.A179T	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	205					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					CACCTTTTAGCGGAATGCTTT	0.458000													141	294					0	0	0.139131	0	0
TAGAP	117289	broad.mit.edu	37	6	159457645	159457645	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:159457645G>T	ENST00000367066.3	-	10	1741	c.1410C>A	c.(1408-1410)gaC>gaA	p.D470E	RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA|TAGAP_ENST00000326965.6_Missense_Mutation_p.D292E|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606466.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	470					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CGGGCGAGCTGTCAGAGGACG	0.567000													34	64					3.28013e-08	3.8418e-08	0.214465	1	0
KCNH5	27133	broad.mit.edu	37	14	63174557	63174557	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:63174557C>G	ENST00000322893.7	-	11	2904	c.2636G>C	c.(2635-2637)gGg>gCg	p.G879A	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	879					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TCGGGCCTCCCCAGCCTTATC	0.502000													36	63					0	0	0.203993	0	0
LINC01410	103352539	broad.mit.edu	37	9	66469021	66469021	+	RNA	SNP	C	C	A	rs28520933	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr9:66469021C>A	ENST00000424345.1	+	0	2588																											tcatatcacaCCATTATTCCA	0.413000													3	9					0.150653	0.157084	0.150653	1	0
MUC4	4585	broad.mit.edu	37	3	195477785	195477785	+	Silent	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:195477785C>A	ENST00000463781.3	-	23	16305	c.15846G>T	c.(15844-15846)ggG>ggT	p.G5282G	MUC4_ENST00000475231.1_Silent_p.G5230G|MUC4_ENST00000346145.4_Silent_p.G1046G|MUC4_ENST00000349607.4_Silent_p.G995G	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	2039					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCACGTCTTCCCCGGAGATGG	0.642000													39	76					3.61848e-18	4.41971e-18	0.098360	1	0
NF1	4763	broad.mit.edu	37	17	29664521	29664521	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:29664521C>T	ENST00000358273.4	+	43	6946	c.6563C>T	c.(6562-6564)tCt>tTt	p.S2188F	NF1_ENST00000356175.3_Missense_Mutation_p.S2167F	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2188					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGGTCATTCTCTCCTGGCTCC	0.438000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			49	1					0	0	0.139131	0	0
ABI2	10152	broad.mit.edu	37	2	204245064	204245064	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:204245064C>T	ENST00000295851.4	+	3	715	c.419C>T	c.(418-420)cCt>cTt	p.P140L	ABI2_ENST00000430574.1_3'UTR|ABI2_ENST00000422511.2_Missense_Mutation_p.P140L|ABI2_ENST00000261016.6_Missense_Mutation_p.P95L|ABI2_ENST00000424558.1_Missense_Mutation_p.P140L|ABI2_ENST00000261017.5_Missense_Mutation_p.P140L|ABI2_ENST00000430418.1_Missense_Mutation_p.P140L			Q9NYB9	ABI2_HUMAN	abl-interactor 2	140					actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding			breast(1)|kidney(3)|large_intestine(1)|liver(2)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	15						ATTAGAAAACCTATTGACTAT	0.323000													25	28					0	0	0.108266	0	0
SCN2A	6326	broad.mit.edu	37	2	166187914	166187914	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:166187914T>A	ENST00000357398.3	+	14	2514	c.2224T>A	c.(2224-2226)Tgt>Agt	p.C742S	SCN2A_ENST00000375427.2_Missense_Mutation_p.C742S|SCN2A_ENST00000283256.6_Missense_Mutation_p.C742S|SCN2A_ENST00000375437.2_Missense_Mutation_p.C742S			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	742					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTGGGACTGTTGTAAACCATG	0.393000													29	23					0	0	0.144211	0	0
SYT10	341359	broad.mit.edu	37	12	33579379	33579379	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:33579379A>T	ENST00000228567.3	-	2	499	c.203T>A	c.(202-204)tTg>tAg	p.L68*	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	68						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GACAACCAACAAGGCCAGTCC	0.388000													47	3					0	0	0.139131	0	0
PIEZO2	63895	broad.mit.edu	37	18	10696471	10696471	+	Silent	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:10696471G>T	ENST00000302079.6	-	42	6554	c.6555C>A	c.(6553-6555)gcC>gcA	p.A2185A	PIEZO2_ENST00000285141.4_Silent_p.A40A|PIEZO2_ENST00000538948.1_Silent_p.A142A|PIEZO2_ENST00000580640.1_Silent_p.A2210A|PIEZO2_ENST00000503781.3_Silent_p.A2185A			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2185						integral to membrane	ion channel activity	p.A40>?(1)|p.A2185>?(1)									CGTCAGTCACGGCGCTATACT	0.527000													6	94					2.0095e-06	2.3062e-06	0.029380	1	0
HGF	3082	broad.mit.edu	37	7	81334811	81334811	+	Silent	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:81334811A>G	ENST00000222390.5	-	17	2131	c.1905T>C	c.(1903-1905)taT>taC	p.Y635Y	HGF_ENST00000457544.2_Silent_p.Y630Y	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	635	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTCCCATTATATAGAGATGTG	0.398000													20	16					0	0	0.055883	0	0
SEC11C	90701	broad.mit.edu	37	18	56819783	56819783	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:56819783G>A	ENST00000587834.1	+	3	685	c.213G>A	c.(211-213)ccG>ccA	p.P71P	SEC11C_ENST00000588875.1_Silent_p.P71P	NM_033280.2	NP_150596.1	Q9BY50	SC11C_HUMAN	SEC11 homolog C (S. cerevisiae)	71					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity			endometrium(1)|large_intestine(4)|liver(2)|lung(2)	9		Colorectal(73;0.175)				GTATGGAGCCGGCCTTTCACA	0.453000													5	461					0	0	0.038147	0	0
RAX	30062	broad.mit.edu	37	18	56939654	56939654	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:56939654G>T	ENST00000334889.3	-	2	668	c.482C>A	c.(481-483)cCg>cAg	p.P161Q	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	161					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		GTACACGTCCGGGTAGTGGGA	0.622000													59	6					1.80625e-27	2.32233e-27	0.139131	1	0
OR4A15	81328	broad.mit.edu	37	11	55135668	55135668	+	Silent	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:55135668T>C	ENST00000314706.3	+	1	309	c.309T>C	c.(307-309)acT>acC	p.T103T		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						TCTATTCTACTGCATTTGCTC	0.413000													85	10					0	0	0.139131	0	0
HCFC2	29915	broad.mit.edu	37	12	104481775	104481775	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:104481775G>A	ENST00000229330.4	+	9	1347	c.1243G>A	c.(1243-1245)Gac>Aac	p.D415N		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	415	Fibronectin type-III 1.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						AGTCAGGATGGACCCTCACAG	0.308000													5	39					0	0	0.021553	0	0
AASS	10157	broad.mit.edu	37	7	121738573	121738573	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:121738573A>T	ENST00000393376.1	-	14	1681	c.1586T>A	c.(1585-1587)gTt>gAt	p.V529D	AASS_ENST00000417368.2_Missense_Mutation_p.V529D|AASS_ENST00000473553.1_5'UTR			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	529	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	GTCCATGCTAACAGGATTAAT	0.343000													14	12					0	0	0.105934	0	0
TSHR	7253	broad.mit.edu	37	14	81574763	81574763	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:81574763C>A	ENST00000541158.2	+	9	981	c.659C>A	c.(658-660)gCa>gAa	p.A220E	TSHR_ENST00000298171.2_Missense_Mutation_p.A220E|TSHR_ENST00000342443.6_Missense_Mutation_p.A220E|RP11-114N19.3_ENST00000557775.1_RNA|TSHR_ENST00000554263.1_Missense_Mutation_p.A220E|TSHR_ENST00000554435.1_Missense_Mutation_p.A220E			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	220					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GACAAAGATGCATTTGGAGGA	0.318000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						38	86					9.84934e-19	1.21168e-18	0.117977	1	0
STXBP5L	9515	broad.mit.edu	37	3	121126342	121126342	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:121126342T>C	ENST00000273666.6	+	24	3183	c.2912T>C	c.(2911-2913)gTt>gCt	p.V971A	STXBP5L_ENST00000471454.1_Missense_Mutation_p.V947A|STXBP5L_ENST00000472879.1_Missense_Mutation_p.V947A|STXBP5L_ENST00000492541.1_Missense_Mutation_p.V971A|STXBP5L_ENST00000497029.1_Missense_Mutation_p.V945A	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	971					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TGCCTTTATGTTCATAACATC	0.418000													73	35					0	0	0.139131	0	0
CASP2	835	broad.mit.edu	37	7	143001815	143001815	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:143001815C>A	ENST00000310447.5	+	10	1407	c.1166C>A	c.(1165-1167)gCt>gAt	p.A389D	CASP2_ENST00000493642.1_3'UTR	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	389					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					TACATCGAGGCTCTTGCTCAA	0.557000													4	113					1.23904e-05	1.38481e-05	0.184627	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904453	144904453	+	Silent	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:144904453G>T	ENST00000370490.1	+	1	4765	c.510G>T	c.(508-510)ctG>ctT	p.L170L	SLITRK2_ENST00000413937.2_Silent_p.L170L|SLITRK2_ENST00000447897.2_Silent_p.L170L|SLITRK2_ENST00000434188.2_Silent_p.L170L|SLITRK2_ENST00000428560.2_Silent_p.L170L			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	170						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					ACAACCTTCTGCTTTCACTGC	0.493000													52	67					2.31418e-15	2.7868e-15	0.139131	1	0
FIGF	2277	broad.mit.edu	37	X	15364372	15364372	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:15364372G>A	ENST00000297904.3	-	7	1377	c.948C>T	c.(946-948)gaC>gaT	p.D316D	FIGF_ENST00000488351.1_5'UTR	NM_004469.4	NP_004460.1	O43915	VEGFD_HUMAN	c-fos induced growth factor (vascular endothelial growth factor D)	316	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17	Hepatocellular(33;0.183)					AGGGGCATCTGTCCTCACAGC	0.443000													60	92					0	0	0.139131	0	0
DST	667	broad.mit.edu	37	6	56481355	56481355	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:56481355A>C	ENST00000370765.6	-	24	7017	c.6910T>G	c.(6910-6912)Tca>Gca	p.S2304A	DST_ENST00000370788.2_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370754.5_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1637					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGTAATTCTGAGTAATACAGA	0.398000													26	77					0	0	0.099896	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													11	26					0	0	0.093190	0	0
ELAVL3	1995	broad.mit.edu	37	19	11577474	11577474	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:11577474C>T	ENST00000359227.3	-	2	602	c.178G>A	c.(178-180)Ggc>Agc	p.G60S	CTC-398G3.6_ENST00000585656.1_3'UTR|ELAVL3_ENST00000438662.2_Missense_Mutation_p.G60S	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	60	RRM 1.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						CCAATGCTGCCGAAGAGACTC	0.542000													119	4					0	0	0.139131	0	0
FNDC3B	64778	broad.mit.edu	37	3	172065056	172065056	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:172065056G>A	ENST00000336824.4	+	21	2518	c.2419G>A	c.(2419-2421)Gat>Aat	p.D807N	FNDC3B_ENST00000415807.2_Missense_Mutation_p.D807N|FNDC3B_ENST00000416957.1_Missense_Mutation_p.D807N	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	807	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ATGGGGAGAAGATGAAGAATC	0.443000													38	63					0	0	0.104719	0	0
RGAG1	57529	broad.mit.edu	37	X	109696973	109696973	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:109696973C>A	ENST00000465301.2	+	3	3374	c.3128C>A	c.(3127-3129)cCa>cAa	p.P1043Q	RGAG1_ENST00000540313.1_Missense_Mutation_p.P1043Q	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1043										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						ATGCCCATGCCACTACCAAGA	0.537000													76	106					1.07363e-35	1.41224e-35	0.139131	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5239922	5239922	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:5239922G>C	ENST00000274181.7	+	16	2545	c.2407G>C	c.(2407-2409)Gtg>Ctg	p.V803L		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	803	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GCACTGGACCGTGGACTGGCC	0.522000													48	397					0	0	0.131918	0	0
USP16	10600	broad.mit.edu	37	21	30421097	30421097	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:30421097T>G	ENST00000334352.4	+	16	2258	c.2027T>G	c.(2026-2028)gTt>gGt	p.V676G	USP16_ENST00000399976.2_Missense_Mutation_p.V676G|USP16_ENST00000535828.1_Missense_Mutation_p.V305G|USP16_ENST00000399975.3_Missense_Mutation_p.V675G	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	676					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						AGGAAGCATGTTTACACCAAT	0.348000													12	13					0	0	0.093190	0	0
ZNF831	128611	broad.mit.edu	37	20	57829275	57829275	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:57829275T>C	ENST00000371030.2	+	5	4511	c.4511T>C	c.(4510-4512)aTa>aCa	p.I1504T		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1504						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACAGATCACATAGCCCAGGAA	0.517000													18	41					0	0	0.055883	0	0
DTL	51514	broad.mit.edu	37	1	212273760	212273760	+	Silent	SNP	C	C	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:212273760C>G	ENST00000366991.4	+	14	1742	c.1428C>G	c.(1426-1428)gcC>gcG	p.A476A	DTL_ENST00000475419.1_3'UTR|DTL_ENST00000542077.1_Silent_p.A434A	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	476					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		CTGCCAAGGCCCGGTCTCCCA	0.532000													63	7					0	0	0.139131	0	0
PTPRS	5802	broad.mit.edu	37	19	5218496	5218496	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:5218496G>A	ENST00000372412.4	-	25	4219	c.3986C>T	c.(3985-3987)gCc>gTc	p.A1329V	PTPRS_ENST00000587303.1_Missense_Mutation_p.A1328V|PTPRS_ENST00000357368.4_Missense_Mutation_p.A1328V|PTPRS_ENST00000353284.2_Missense_Mutation_p.A897V|PTPRS_ENST00000348075.2_Missense_Mutation_p.A1306V|PTPRS_ENST00000592099.1_Missense_Mutation_p.A897V|PTPRS_ENST00000262963.6_Missense_Mutation_p.A1324V|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000588012.1_Missense_Mutation_p.A1306V			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1328					cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGCGAGGTCGGCATTGTTCAG	0.527000													4	116					0	0	0.184627	0	0
NIM1K	167359	broad.mit.edu	37	5	43245944	43245944	+	Missense_Mutation	SNP	G	G	A	rs143879963	byFrequency	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:43245944G>A	ENST00000512796.1	+	2	1566	c.67G>A	c.(67-69)Gac>Aac	p.D23N	NIM1_ENST00000326035.2_Missense_Mutation_p.D23N			Q8IY84	NIM1_HUMAN		23							ATP binding|magnesium ion binding|protein serine/threonine kinase activity										GGATCGGCGCGACAGTGTAGA	0.597000													7	408					0	0	0.047766	0	0
FAM127C	441518	broad.mit.edu	37	X	134156334	134156334	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:134156334G>T	ENST00000391440.1	-	1	225	c.156C>A	c.(154-156)ttC>ttA	p.F52L		NM_001078173.1	NP_001071641.1	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	52										breast(1)|endometrium(2)|large_intestine(1)|lung(2)	6	Acute lymphoblastic leukemia(192;0.000127)					TCTCGTCCACGAACATGTAGG	0.617000													55	77					5.47352e-35	7.14483e-35	0.139131	1	0
STAT3	6774	broad.mit.edu	37	17	40498723	40498723	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:40498723G>A	ENST00000264657.5	-	3	449	c.137C>T	c.(136-138)gCg>gTg	p.A46V	STAT3_ENST00000389272.3_5'UTR|STAT3_ENST00000588969.1_Missense_Mutation_p.A46V|STAT3_ENST00000585517.1_Missense_Mutation_p.A46V|STAT3_ENST00000404395.3_Missense_Mutation_p.A46V	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	46					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding	p.A46V(2)		breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TTTGCTGGCCGCATATGCCCT	0.433000									Hyperimmunoglobulin E Recurrent Infection Syndrome				5	326					0	0	0.184627	0	0
FAT3	120114	broad.mit.edu	37	11	92533300	92533300	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:92533300T>G	ENST00000298047.6	+	9	7138	c.7121T>G	c.(7120-7122)cTg>cGg	p.L2374R	FAT3_ENST00000525166.1_Missense_Mutation_p.L2224R|FAT3_ENST00000409404.2_Missense_Mutation_p.L2374R			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2374	Cadherin 21.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTCCCATCACTGAGCAGTGAG	0.418000										TCGA Ovarian(4;0.039)			20	30					0	0	0.055883	0	0
GPRC6A	222545	broad.mit.edu	37	6	117113721	117113721	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:117113721G>T	ENST00000310357.3	-	6	2386	c.2365C>A	c.(2365-2367)Ctc>Atc	p.L789I	GPRC6A_ENST00000368549.3_Missense_Mutation_p.L718I|GPRC6A_ENST00000530250.1_Missense_Mutation_p.L614I	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	789					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AAGTAAATGAGCATGCCAAAT	0.368000													37	17					2.05212e-20	2.5614e-20	0.080422	1	0
RTP1	132112	broad.mit.edu	37	3	186917481	186917481	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:186917481C>T	ENST00000312295.4	+	2	445	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	139					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CGGCACGGCGCGGCTGGACGA	0.667000													15	44					0	0	0.175082	0	0
ZNF107	51427	broad.mit.edu	37	7	64166863	64166863	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:64166863C>T	ENST00000395391.1	+	4	1556	c.181C>T	c.(181-183)Cat>Tat	p.H61Y	ZNF107_ENST00000423627.1_Missense_Mutation_p.H61Y|ZNF107_ENST00000344930.3_Missense_Mutation_p.H61Y			Q9UII5	ZN107_HUMAN	zinc finger protein 107	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CAAAGGAGGTCATAATACAGT	0.338000													7	16					0	0	0.038147	0	0
CEP192	55125	broad.mit.edu	37	18	13116408	13116408	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:13116408C>T	ENST00000506447.1	+	43	7402	c.7322C>T	c.(7321-7323)gCc>gTc	p.A2441V	CEP192_ENST00000325971.8_Missense_Mutation_p.A1845V|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_Missense_Mutation_p.A1966V	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	2036										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GGAGTTTATGCCCCAGAGGAT	0.408000													4	112					0	0	0.021553	0	0
ARL4A	10124	broad.mit.edu	37	7	12728378	12728378	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:12728378A>G	ENST00000396663.1	+	2	981	c.499A>G	c.(499-501)Acc>Gcc	p.T167A	ARL4A_ENST00000356797.3_Missense_Mutation_p.T167A|ARL4A_ENST00000396662.1_Missense_Mutation_p.T167A|ARL4A_ENST00000396664.2_Missense_Mutation_p.T167A|ARL4A_ENST00000404894.1_Missense_Mutation_p.T167A	NM_001037164.2|NM_001195396.1|NM_005738.4|NM_212460.3	NP_001032241.1|NP_001182325.1|NP_005729.1|NP_997625.1	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	167					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding			NS(2)|lung(3)|ovary(1)	6				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		TTTGCAGCCTACCTGTGCAAT	0.378000													18	36					0	0	0.175082	0	0
NFKB2	4791	broad.mit.edu	37	10	104156244	104156244	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:104156244C>T	ENST00000369966.3	+	4	392	c.142C>T	c.(142-144)Cag>Tag	p.Q48*	NFKB2_ENST00000189444.6_Nonsense_Mutation_p.Q48*|NFKB2_ENST00000428099.1_Nonsense_Mutation_p.Q48*	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	48	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		ACAGCCTAAGCAGGTGAGTGA	0.602000			T	IGH@	B-NHL								9	1					0	0	0.058154	0	0
ERC1	23085	broad.mit.edu	37	12	1289831	1289831	+	Silent	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:1289831C>T	ENST00000397203.2	+	9	2269	c.1863C>T	c.(1861-1863)gcC>gcT	p.A621A	ERC1_ENST00000360905.4_Silent_p.A621A|ERC1_ENST00000546231.2_Silent_p.A621A|ERC1_ENST00000589028.1_Silent_p.A621A|ERC1_ENST00000536573.2_3'UTR|ERC1_ENST00000543086.3_Silent_p.A593A|ERC1_ENST00000355446.5_Silent_p.A621A			Q8IUD2	RB6I2_HUMAN	ELKS/RAB6-interacting/CAST family member 1	621					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			NS(1)|breast(2)|cervix(2)|endometrium(2)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			TGGAGGAGGCCCTTGCAGAGA	0.473000													54	4					0	0	0.139131	0	0
CXorf66	347487	broad.mit.edu	37	X	139040234	139040234	+	Silent	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:139040234G>T	ENST00000370540.1	-	2	254	c.231C>A	c.(229-231)tcC>tcA	p.S77S		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	77						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						TTCCTGCTTTGGACGCATCAT	0.343000													184	261					1.1776e-91	1.58559e-91	0.139131	1	0
ZNF600	162966	broad.mit.edu	37	19	53269487	53269487	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:53269487G>T	ENST00000338230.3	-	3	1789	c.1522C>A	c.(1522-1524)Cgt>Agt	p.R508S		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	508				R -> H (in Ref. 1; BAD18414).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R508C(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		GACCTCAGACGGAAGGTCTTG	0.443000													5	509					0.184627	0.191341	0.184627	1	0
NCOR1	9611	broad.mit.edu	37	17	16052788	16052788	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:16052788T>C	ENST00000268712.3	-	9	1143	c.886A>G	c.(886-888)Aga>Gga	p.R296G	NCOR1_ENST00000395851.1_Missense_Mutation_p.R296G|NCOR1_ENST00000395848.1_Missense_Mutation_p.R187G	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	296	Interaction with SIN3A/B.|Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCATGATTTCTTCTTTTAAAA	0.323000													44	2					0	0	0.131918	0	0
ARHGEF38	54848	broad.mit.edu	37	4	106587438	106587438	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:106587438G>T	ENST00000420470.2	+	11	1794	c.1650G>T	c.(1648-1650)agG>agT	p.R550S	ARHGEF38_ENST00000508036.2_3'UTR	NM_001242729.1	NP_001229658.1	Q9NXL2	ARH38_HUMAN	Rho guanine nucleotide exchange factor (GEF) 38	0					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(3)	11						TTATTGAGAGGAAACTCAGTT	0.373000													7	0					0.000442599	0.000473028	0.058154	1	0
CLDN9	9080	broad.mit.edu	37	16	3063820	3063820	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:3063820G>C	ENST00000445369.2	+	1	1364	c.457G>C	c.(457-459)Gct>Cct	p.A153P		NM_020982.3	NP_066192.1	O95484	CLD9_HUMAN	claudin 9	153					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						CCCCCTGGTGGCTGAGGCCCT	0.697000													9	4					0	0	0.069234	0	0
LCT	3938	broad.mit.edu	37	2	136562486	136562486	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:136562486G>T	ENST00000264162.2	-	10	4325	c.4315C>A	c.(4315-4317)Ctg>Atg	p.L1439M		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1439	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGGTTCTGCAGGGTGACCAGA	0.532000													9	18					0.000274275	0.000296842	0.047766	1	0
FLG2	388698	broad.mit.edu	37	1	152323527	152323527	+	Silent	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:152323527G>T	ENST00000388718.5	-	3	6807	c.6735C>A	c.(6733-6735)tcC>tcA	p.S2245S	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2245							calcium ion binding|structural molecule activity	p.S2245S(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGTTGTCCTGGACCCTCTCT	0.527000													8	293					0.000274275	0.000296842	0.047766	1	0
MYO16	23026	broad.mit.edu	37	13	109475595	109475595	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr13:109475595A>T	ENST00000356711.2	+	9	1126	c.1000A>T	c.(1000-1002)Att>Ttt	p.I334F	MYO16_ENST00000251041.5_Missense_Mutation_p.I334F|MYO16_ENST00000357550.2_Missense_Mutation_p.I334F	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	334					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TGAAGAGATCATTCACGATCT	0.428000													6	113					0	0	0.038147	0	0
KRT71	112802	broad.mit.edu	37	12	52943945	52943945	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:52943945T>G	ENST00000267119.5	-	2	593	c.524A>C	c.(523-525)aAc>aCc	p.N175T		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	175	Linker 1.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CTCCAGGTTGTTCTTGCAGTT	0.602000													128	8					0	0	0.139131	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55253586	55253586	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:55253586T>A	ENST00000342376.3	+	3	262	c.231T>A	c.(229-231)caT>caA	p.H77Q	KIR2DL3_ENST00000434419.2_Missense_Mutation_p.H77Q|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR2DL4_ENST00000396284.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		GAGAGCACCATGATGGGGTCT	0.507000													6	526					0	0	0.069234	0	0
WNK3	65267	broad.mit.edu	37	X	54337558	54337558	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:54337558A>G	ENST00000354646.2	-	3	1142	c.704T>C	c.(703-705)tTa>tCa	p.L235S	WNK3_ENST00000375159.2_Missense_Mutation_p.L235S|WNK3_ENST00000375169.3_Missense_Mutation_p.L235S	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	235	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						TTACGTCTTTAAGGTCCCAGA	0.308000													14	21					0	0	0.160694	0	0
SLC13A3	64849	broad.mit.edu	37	20	45217842	45217842	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:45217842G>C	ENST00000279027.4	-	7	991	c.973C>G	c.(973-975)Cga>Gga	p.R325G	SLC13A3_ENST00000472148.1_Missense_Mutation_p.R278G|SLC13A3_ENST00000396360.1_Missense_Mutation_p.R278G|SLC13A3_ENST00000290317.5_Missense_Mutation_p.R278G|SLC13A3_ENST00000372121.1_Missense_Mutation_p.R275G|SLC13A3_ENST00000495082.1_Missense_Mutation_p.R278G|SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000413164.2_Missense_Mutation_p.R275G	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	325						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	ATTACAGCTCGAGCCCTATCT	0.483000													27	57					0	0	0.125774	0	0
SMG1	23049	broad.mit.edu	37	16	18883895	18883895	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:18883895T>C	ENST00000446231.2	-	14	2354	c.1942A>G	c.(1942-1944)Att>Gtt	p.I648V	SMG1_ENST00000389467.3_Missense_Mutation_p.I648V			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	648	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CTGTGCACAATCATCAGATTC	0.398000													4	13					0	0	0.150653	0	0
LSS	4047	broad.mit.edu	37	21	47611873	47611873	+	Splice_Site	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:47611873C>T	ENST00000397728.3	-	21	2067	c.1988_splice	c.e21-1	p.R663_splice	LSS_ENST00000457828.2_Splice_Site_p.R583_splice|LSS_ENST00000522411.1_Splice_Site_p.R652_splice|LSS_ENST00000356396.4_Splice_Site_p.R663_splice	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	663					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					TGTCAGGATGCCTGGTGGAAG	0.597000													3	12					0	0	0.150653	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50723381	50723381	+	Nonstop_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:50723381A>G	ENST00000515869.1	-	6	3304	c.3184T>C	c.(3184-3186)Tag>Cag	p.*1062Q	ERCC6_ENST00000355832.5_Intron|ERCC6-PGBD3_ENST00000447839.2_Nonstop_Mutation_p.*1062Q|PGBD3_ENST00000374127.3_Nonstop_Mutation_p.*594Q|PGBD3_ENST00000508005.2_Nonstop_Mutation_p.*594Q|PGBD3_ENST00000603152.1_Nonstop_Mutation_p.*1062Q	NM_001277059.1	NP_001263988.1																					GACACCTGCTATTCAGTGTGA	0.398000													37	3					0	0	0.203993	0	0
FAM120B	84498	broad.mit.edu	37	6	170627473	170627473	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:170627473G>T	ENST00000476287.1	+	2	1103	c.995G>T	c.(994-996)aGt>aTt	p.S332I	FAM120B_ENST00000252510.9_Intron|FAM120B_ENST00000540480.1_Missense_Mutation_p.S344I|FAM120B_ENST00000537664.1_Missense_Mutation_p.S355I	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	332					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		ATATCCACGAGTTCAGACGCC	0.433000													57	41					3.76997e-23	4.77529e-23	0.139131	1	0
METTL15	196074	broad.mit.edu	37	11	28352293	28352293	+	Silent	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:28352293T>C	ENST00000407364.3	+	7	1481	c.1129T>C	c.(1129-1131)Ttg>Ctg	p.L377L	METTL15_ENST00000342303.5_3'UTR|METTL15_ENST00000303459.6_3'UTR|METTL15_ENST00000406787.3_3'UTR			A6NJ78	MET15_HUMAN	methyltransferase like 15	377							methyltransferase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	14						AATGTGGGAATTGATACACAA	0.408000													2	4					0	0	0.150653	0	0
MCM6	4175	broad.mit.edu	37	2	136598504	136598504	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:136598504C>A	ENST00000264156.2	-	17	2427	c.2367G>T	c.(2365-2367)gaG>gaT	p.E789D		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	789					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CCTGGGTGAGCTCAATTAGAA	0.428000													9	12					3.07112e-06	3.47789e-06	0.080935	1	0
PRRG3	79057	broad.mit.edu	37	X	150869182	150869182	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:150869182G>C	ENST00000370353.3	+	4	763	c.373G>C	c.(373-375)Gcc>Ccc	p.A125P	PRRG3_ENST00000538575.1_Missense_Mutation_p.A125P|PRRG3_ENST00000370354.1_3'UTR			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	125						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCAGTCGCGCCGGGCACAC	0.632000													59	87					0	0	0.139131	0	0
MAD2L1BP	9587	broad.mit.edu	37	6	43604260	43604260	+	Silent	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:43604260T>C	ENST00000451025.2	+	3	495	c.285T>C	c.(283-285)ccT>ccC	p.P95P	MAD2L1BP_ENST00000372171.4_Silent_p.P63P|MAD2L1BP_ENST00000508232.1_3'UTR	NM_001003690.1	NP_001003690.1	Q15013	MD2BP_HUMAN	MAD2L1 binding protein	63					mitotic cell cycle checkpoint|regulation of exit from mitosis	cytoplasm|nucleus|spindle	protein binding			breast(1)|large_intestine(1)|lung(3)	5	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000351)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TTCCTGGGCCTGTGAGCCAGG	0.502000													3	51					0	0	0.150653	0	0
U2SURP	23350	broad.mit.edu	37	3	142769851	142769851	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:142769851A>T	ENST00000397933.2	+	24	2670	c.1388A>T	c.(1387-1389)cAg>cTg	p.Q463L	U2SURP_ENST00000473835.2_Missense_Mutation_p.Q872L|U2SURP_ENST00000493598.2_Missense_Mutation_p.Q871L			O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	872					RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						CAGAGTTTTCAGGAGCAAGTA	0.318000													37	14					0	0	0.092188	0	0
GLA	2717	broad.mit.edu	37	X	100653424	100653424	+	Silent	SNP	A	A	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:100653424A>C	ENST00000218516.3	-	6	954	c.933T>G	c.(931-933)ctT>ctG	p.L311L	RPL36A-HNRNPH2_ENST00000409170.3_Intron|GLA_ENST00000493905.1_5'UTR	NM_000169.2	NP_000160.1	P06280	AGAL_HUMAN	galactosidase, alpha	311					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14					Agalsidase beta(DB00103)	CCTTATCCTGAAGGAGAGCTT	0.453000													138	127					0	0	0.139131	0	0
SLFN5	162394	broad.mit.edu	37	17	33592660	33592660	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:33592660C>A	ENST00000299977.4	+	5	2577	c.2429C>A	c.(2428-2430)gCa>gAa	p.A810E	SLFN5_ENST00000542451.1_3'UTR	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	810					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		CTTCTAACAGCAATGAGGAAG	0.438000													6	35					8.12818e-05	8.96722e-05	0.029380	1	0
FAM47B	170062	broad.mit.edu	37	X	34961910	34961910	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:34961910C>T	ENST00000329357.5	+	1	998	c.962C>T	c.(961-963)cCg>cTg	p.P321L		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	321	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AGTCTCTGCCCGGAGCCTCCC	0.597000													9	122					0	0	0.069234	0	0
DMD	1756	broad.mit.edu	37	X	31224708	31224708	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:31224708T>A	ENST00000357033.4	-	66	9846	c.9640A>T	c.(9640-9642)Aag>Tag	p.K3214*	DMD_ENST00000343523.2_Nonsense_Mutation_p.K754*|DMD_ENST00000361471.4_Nonsense_Mutation_p.K146*|DMD_ENST00000378723.3_Nonsense_Mutation_p.K146*|DMD_ENST00000474231.1_Nonsense_Mutation_p.K754*|DMD_ENST00000359836.1_Nonsense_Mutation_p.K754*|DMD_ENST00000378707.3_Nonsense_Mutation_p.K754*|DMD_ENST00000378680.2_Nonsense_Mutation_p.K146*|DMD_ENST00000378702.4_Nonsense_Mutation_p.K146*|DMD_ENST00000378677.2_Nonsense_Mutation_p.K3210*|DMD_ENST00000541735.1_Nonsense_Mutation_p.K754*	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3214	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CATCTGTACTTGTCTTCCAAA	0.373000													19	21					0	0	0.189662	0	0
UNC5D	137970	broad.mit.edu	37	8	35648015	35648015	+	Silent	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:35648015C>T	ENST00000287272.2	+	16	2609	c.2589C>T	c.(2587-2589)ctC>ctT	p.L863L	UNC5D_ENST00000404895.2_Silent_p.L932L|UNC5D_ENST00000420357.1_Silent_p.L865L|UNC5D_ENST00000416672.1_Silent_p.L937L|UNC5D_ENST00000453357.2_Silent_p.L927L|UNC5D_ENST00000449677.1_Silent_p.L508L			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	932	Death.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACACGAAACTCTCAAACATTT	0.498000													41	71					0	0	0.117977	0	0
NR1H2	7376	broad.mit.edu	37	19	50883110	50883110	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:50883110A>G	ENST00000542413.1	+	12	1621	c.194A>G	c.(193-195)tAc>tGc	p.Y65C	NR1H2_ENST00000411902.2_Missense_Mutation_p.Y237C|NR1H2_ENST00000253727.5_Missense_Mutation_p.Y334C|NR1H2_ENST00000593926.1_Missense_Mutation_p.Y334C|NR1H2_ENST00000598168.1_Missense_Mutation_p.Y304C|NR1H2_ENST00000599105.1_Missense_Mutation_p.Y290C			P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	334					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GACTTCACCTACAGCAAGGAC	0.622000													34	30					0	0	0.193644	0	0
SLC9A6	10479	broad.mit.edu	37	X	135104854	135104854	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:135104854C>T	ENST00000370695.4	+	11	1495	c.1460C>T	c.(1459-1461)gCt>gTt	p.A487V	SLC9A6_ENST00000370701.1_Missense_Mutation_p.A435V|SLC9A6_ENST00000370698.3_Missense_Mutation_p.A455V	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	455					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					ATGATGTTTGCTGGTAAGTTG	0.393000													15	26					0	0	0.160694	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067261	18067261	+	Missense_Mutation	SNP	G	G	T	rs112075478	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:18067261G>T	ENST00000506618.2	-	1	225	c.145C>A	c.(145-147)Cgt>Agt	p.R49S		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	49					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity	p.R49C(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TCCTCTCCACGCACACTCTCA	0.488000													84	104					2.5963e-48	3.44161e-48	0.139131	1	0
FBXO25	26260	broad.mit.edu	37	8	408529	408529	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:408529A>G	ENST00000352684.2	+	7	1037	c.620A>G	c.(619-621)cAg>cGg	p.Q207R	FBXO25_ENST00000276326.5_Missense_Mutation_p.Q274R|FBXO25_ENST00000350302.3_Missense_Mutation_p.Q274R|FBXO25_ENST00000382824.1_Missense_Mutation_p.Q207R|FBXO25_ENST00000519376.1_3'UTR	NM_012173.3	NP_036305.2	Q8TCJ0	FBX25_HUMAN	F-box protein 25	274						nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		AAGCTTTGTCAGTACCATTTT	0.517000													57	76					0	0	0.139131	0	0
HCFC2	29915	broad.mit.edu	37	12	104461846	104461846	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:104461846T>C	ENST00000229330.4	+	3	538	c.434T>C	c.(433-435)cTg>cCg	p.L145P		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	145					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						TTTGGTGGCCTGGCAAACGAA	0.398000													3	107					0	0	0.115264	0	0
MROH2B	133558	broad.mit.edu	37	5	41039551	41039551	+	Splice_Site	SNP	T	T	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:41039551T>G	ENST00000399564.4	-	20	2510	c.2061_splice	c.e20+1	p.K687_splice	MROH2B_ENST00000506092.2_Splice_Site_p.K242_splice	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCTTCTTACCTTACATCGATT	0.333000													37	10					0	0	0.193644	0	0
TP53	7157	broad.mit.edu	37	17	7577114	7577114	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:7577114C>A	ENST00000420246.2	-	8	956	c.824G>T	c.(823-825)tGt>tTt	p.C275F	TP53_ENST00000269305.4_Missense_Mutation_p.C275F|TP53_ENST00000455263.2_Missense_Mutation_p.C275F|TP53_ENST00000359597.4_Missense_Mutation_p.C275F|TP53_ENST00000445888.2_Missense_Mutation_p.C275F|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	275	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C275Y(53)|p.C275F(37)|p.0?(8)|p.C275fs*70(3)|p.?(2)|p.C275S(2)|p.C275fs*20(1)|p.L265_K305del41(1)|p.R273_C275delRVC(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.A276fs*29(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGACAGGCACAAACACGCAC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			57	4					1.48341e-19	1.83814e-19	0.139131	1	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473333	22473333	+	RNA	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr15:22473333A>G	ENST00000557788.2	-	0	20																											CCAGGAGGAGAAAGAACCACA	0.512000													4	19					0	0	0.184627	0	0
ADAM15	8751	broad.mit.edu	37	1	155030756	155030756	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:155030756G>C	ENST00000356955.2	+	15	1857	c.1756G>C	c.(1756-1758)Ggt>Cgt	p.G586R	ADAM15_ENST00000447332.3_Missense_Mutation_p.G570R|ADAM15_ENST00000359280.4_Missense_Mutation_p.G586R|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000449910.2_Missense_Mutation_p.G586R|ADAM15_ENST00000368410.2_Missense_Mutation_p.G292R|ADAM15_ENST00000368412.3_Missense_Mutation_p.G586R|ADAM15_ENST00000368413.1_Missense_Mutation_p.G292R|ADAM15_ENST00000271836.6_Missense_Mutation_p.G586R|ADAM15_ENST00000531455.1_Missense_Mutation_p.G596R|ADAM15_ENST00000355956.2_Missense_Mutation_p.G586R|ADAM15_ENST00000360674.4_Missense_Mutation_p.G586R	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	586	Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GTGCCAGACAGGTAGGACCCA	0.582000													19	14					0	0	0.204396	0	0
SIRPA	140885	broad.mit.edu	37	20	1902301	1902301	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:1902301G>A	ENST00000358771.4	+	3	849	c.697G>A	c.(697-699)Gtc>Atc	p.V233I	SIRPA_ENST00000356025.3_Missense_Mutation_p.V233I|SIRPA_ENST00000400068.3_Missense_Mutation_p.V233I	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	233	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V233I(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGTGGCCCACGTCACCTTGCA	0.617000													3	40					0	0	0.115264	0	0
TCF23	150921	broad.mit.edu	37	2	27373194	27373194	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:27373194G>A	ENST00000296096.5	+	2	556	c.426G>A	c.(424-426)ccG>ccA	p.P142P		NM_175769.2	NP_786951.1	Q7RTU1	TCF23_HUMAN	transcription factor 23	142					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus				large_intestine(2)|lung(11)|prostate(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGCCTGGCCGCCCTTCCTGC	0.622000													4	113					0	0	0.150653	0	0
SIRPA	140885	broad.mit.edu	37	20	1902292	1902292	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:1902292G>A	ENST00000358771.4	+	3	840	c.688G>A	c.(688-690)Gtg>Atg	p.V230M	SIRPA_ENST00000356025.3_Missense_Mutation_p.V230M|SIRPA_ENST00000400068.3_Missense_Mutation_p.V230M	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	230	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V230M(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CATCTGCGAGGTGGCCCACGT	0.612000													3	35					0	0	0.115264	0	0
DLC1	10395	broad.mit.edu	37	8	13259057	13259057	+	Silent	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:13259057A>T	ENST00000276297.4	-	3	1504	c.1095T>A	c.(1093-1095)ctT>ctA	p.L365L	DLC1_ENST00000511869.1_Silent_p.L365L|DLC1_ENST00000316609.5_Silent_p.L365L	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	365					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TGTCCTGATCAAGCTGGTCCA	0.493000													50	44					0	0	0.139131	0	0
MUC17	140453	broad.mit.edu	37	7	100683451	100683451	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:100683451G>A	ENST00000306151.4	+	3	8818	c.8754G>A	c.(8752-8754)atG>atA	p.M2918I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2918	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTACCAGCATGCCAATCTCAA	0.483000													4	70					0	0	0.184627	0	0
SGOL2	151246	broad.mit.edu	37	2	201436706	201436706	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:201436706A>G	ENST00000357799.4	+	7	1735	c.1637A>G	c.(1636-1638)gAt>gGt	p.D546G		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	546					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TTAGAAAAAGATAACTTACTC	0.333000													20	26					0	0	0.204396	0	0
PHEX	5251	broad.mit.edu	37	X	22245656	22245656	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:22245656G>A	ENST00000379374.4	+	20	2563	c.1998G>A	c.(1996-1998)caG>caA	p.Q666Q	PHEX_ENST00000535894.1_Silent_p.Q569Q|PHEX_ENST00000418858.3_Silent_p.Q369Q|PHEX_ENST00000537599.1_Silent_p.Q666Q	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	666					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						ACAGAAGGCAGGGACTTGAGG	0.488000													38	57					0	0	0.104719	0	0
ZNF425	155054	broad.mit.edu	37	7	148801967	148801967	+	Silent	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:148801967A>G	ENST00000378061.2	-	4	1128	c.996T>C	c.(994-996)tgT>tgC	p.C332C		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	332					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CACACTGCGGACACTGGAAGG	0.667000													7	27					0	0	0.093190	0	0
SNAPC4	6621	broad.mit.edu	37	9	139270916	139270916	+	Silent	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr9:139270916A>T	ENST00000298532.2	-	22	4670	c.4302T>A	c.(4300-4302)ggT>ggA	p.G1434G		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	1434					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CAGAGCATTTACCAGAGTCTG	0.617000													13	8					0	0	0.093190	0	0
CHRNA2	1135	broad.mit.edu	37	8	27320983	27320983	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:27320983G>A	ENST00000407991.1	-	6	1585	c.977C>T	c.(976-978)cCg>cTg	p.P326L	CHRNA2_ENST00000240132.2_Missense_Mutation_p.P311L|CHRNA2_ENST00000520933.2_Missense_Mutation_p.P326L	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	326						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GCCGATGAGCGGGATGACCAG	0.587000													21	33					0	0	0.062417	0	0
CNOT3	4849	broad.mit.edu	37	19	54652228	54652228	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:54652228A>C	ENST00000406403.1	+	10	2843	c.1240A>C	c.(1240-1242)Agc>Cgc	p.S414R	CNOT3_ENST00000221232.5_Missense_Mutation_p.S414R|CNOT3_ENST00000358389.3_Missense_Mutation_p.S233R			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	414	Gly/Ser-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					cagtagtaacagcagtgccgg	0.736000													9	18					0	0	0.047766	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559503	140559503	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:140559503C>G	ENST00000239444.2	+	1	2133	c.1888C>G	c.(1888-1890)Ctg>Gtg	p.L630V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		630	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCGCCAGGCTGCTGAGCGA	0.692000													25	2					0	0	0.080422	0	0
ZNF112	7665	broad.mit.edu	37	19	44832502	44832502	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:44832502T>C	ENST00000354340.4	-	4	1859	c.1808A>G	c.(1807-1809)tAc>tGc	p.Y603C	ZNF112_ENST00000337401.4_Missense_Mutation_p.Y609C|ZNF112_ENST00000536500.1_Missense_Mutation_p.Y626C	NM_013380.3	NP_037512.3			zinc finger protein 112																		CTCACACTTGTATGGTTTTTC	0.453000													4	182					0	0	0.150653	0	0
GCLC	2729	broad.mit.edu	37	6	53379269	53379269	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:53379269C>T	ENST00000229416.6	-	5	1070	c.587G>A	c.(586-588)aGg>aAg	p.R196K	GCLC_ENST00000514004.1_Missense_Mutation_p.R196K	NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	196					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TTCTCCTCTCCTATGTCGGAT	0.383000													26	72					0	0	0.116897	0	0
OR4C15	81309	broad.mit.edu	37	11	55322231	55322231	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:55322231G>C	ENST00000314644.2	+	1	449	c.449G>C	c.(448-450)tGc>tCc	p.C150S		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TTTGAAGGCTGCATGATGCAG	0.493000										HNSCC(20;0.049)			110	8					0	0	0.139131	0	0
POF1B	79983	broad.mit.edu	37	X	84560880	84560880	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:84560880T>C	ENST00000262753.4	-	13	1499	c.1354A>G	c.(1354-1356)Aaa>Gaa	p.K452E	POF1B_ENST00000373145.3_Missense_Mutation_p.K452E	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	452							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TCATCCATTTTAGCCTGCAAC	0.388000													46	46					0	0	0.139131	0	0
KCNS2	3788	broad.mit.edu	37	8	99440424	99440424	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:99440424C>T	ENST00000287042.4	+	2	567	c.217C>T	c.(217-219)Cgc>Tgc	p.R73C	KCNS2_ENST00000521839.1_Missense_Mutation_p.R73C	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	73						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CTACTTCGACCGCAACCCTGA	0.597000													73	46					0	0	0.139131	0	0
DISC1	27185	broad.mit.edu	37	1	231954127	231954127	+	Silent	SNP	A	A	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:231954127A>T	ENST00000439617.2	+	9	1898	c.1845A>T	c.(1843-1845)acA>acT	p.T615T	DISC1_ENST00000537876.1_Intron|DISC1_ENST00000602281.1_Silent_p.T615T|DISC1_ENST00000366636.4_Silent_p.T615T|DISC1_ENST00000602873.1_3'UTR|DISC1_ENST00000366633.3_Silent_p.T615T|DISC1_ENST00000535983.1_Silent_p.T615T|DISC1_ENST00000539444.1_3'UTR|DISC1_ENST00000366637.3_5'UTR|TRAX_ENST00000602962.1_3'UTR	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	615	Interaction with ATF4 and ATF5.|Interaction with TRAF3IP1.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				GATCATTAACATCAGAGAGAG	0.458000													9	70					0	0	0.047766	0	0
DMD	1756	broad.mit.edu	37	X	31947760	31947760	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:31947760C>G	ENST00000357033.4	-	47	7071	c.6865G>C	c.(6865-6867)Gat>Cat	p.D2289H	DMD_ENST00000359836.1_5'UTR|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000474231.1_5'UTR|DMD_ENST00000378677.2_Missense_Mutation_p.D2285H|DMD_ENST00000343523.2_5'UTR|DMD_ENST00000541735.1_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2289					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCAAGTTTATCTTGCTCTTCT	0.428000													40	164					0	0	0.086207	0	0
LAMP2	3920	broad.mit.edu	37	X	119589315	119589315	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:119589315C>A	ENST00000371335.4	-	3	430	c.294G>T	c.(292-294)tgG>tgT	p.W98C	LAMP2_ENST00000434600.2_Missense_Mutation_p.W98C|LAMP2_ENST00000538785.1_Intron|LAMP2_ENST00000200639.4_Missense_Mutation_p.W98C|LAMP2_ENST00000540603.1_Missense_Mutation_p.W51C	NM_013995.2	NP_054701.1	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2	98	First lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				endometrium(4)|large_intestine(2)|lung(5)|ovary(2)|urinary_tract(2)	15						AATTCGCAATCCAGGAAAAGC	0.428000													51	71					5.13769e-22	6.45989e-22	0.139131	1	0
NBEAL1	65065	broad.mit.edu	37	2	204036657	204036657	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:204036657G>T	ENST00000449802.1	+	39	6355	c.6022G>T	c.(6022-6024)Gta>Tta	p.V2008L		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2008	BEACH.						binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CTAGAAATGGGTAAACAGAGA	0.348000													11	13					3.07112e-06	3.47789e-06	0.080935	1	0
ARSD	414	broad.mit.edu	37	X	2825531	2825531	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:2825531C>A	ENST00000381154.1	-	10	1638	c.1563G>T	c.(1561-1563)agG>agT	p.R521S		NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	521						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGAGGGGTCCCTGGAGAGGT	0.701000													9	12					0.000442599	0.000473028	0.058154	1	0
OR8H2	390151	broad.mit.edu	37	11	55872537	55872537	+	Missense_Mutation	SNP	A	A	G	rs61746549	byFrequency	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:55872537A>G	ENST00000313503.1	+	1	19	c.19A>G	c.(19-21)Aac>Gac	p.N7D		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.N7D(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TAGAAGGAATAACACAAATGT	0.438000										HNSCC(53;0.14)			3	134					0	0	0.184627	0	0
SCN7A	6332	broad.mit.edu	37	2	167289191	167289191	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:167289191A>C	ENST00000409855.1	-	15	2355	c.2229T>G	c.(2227-2229)aaT>aaG	p.N743K		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	743					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TTTTTGCTTCATTATTCTCTT	0.348000													12	10					0	0	0.080935	0	0
SCN2A	6326	broad.mit.edu	37	2	166187865	166187865	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:166187865C>G	ENST00000357398.3	+	14	2465	c.2175C>G	c.(2173-2175)tgC>tgG	p.C725W	SCN2A_ENST00000375427.2_Missense_Mutation_p.C725W|SCN2A_ENST00000283256.6_Missense_Mutation_p.C725W|SCN2A_ENST00000375437.2_Missense_Mutation_p.C725W			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	725					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GACAGAAATGCCCACCATGCT	0.358000													13	20					0	0	0.105934	0	0
PLK3	1263	broad.mit.edu	37	1	45270161	45270161	+	Nonsense_Mutation	SNP	C	C	A	rs17880829		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:45270161C>A	ENST00000372201.4	+	12	1732	c.1493C>A	c.(1492-1494)tCg>tAg	p.S498*	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	498	POLO box 1.		S -> L (in dbSNP:rs17880829).			membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					ATGGCCCTGTCGGCCAACAGA	0.562000													35	5					1.06647e-15	1.29338e-15	0.193644	1	0
DNASE1L1	1774	broad.mit.edu	37	X	153633815	153633815	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:153633815G>A	ENST00000369809.1	-	4	724	c.95C>T	c.(94-96)gCc>gTc	p.A32V	DNASE1L1_ENST00000393638.1_Missense_Mutation_p.A32V	NM_001009932.1	NP_001009932.1	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1	32					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			lung(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCCACCTTGGCCAGTGTCAG	0.597000													8	14					0	0	0.047766	0	0
WNK3	65267	broad.mit.edu	37	X	54321231	54321231	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:54321231G>T	ENST00000354646.2	-	8	1886	c.1448C>A	c.(1447-1449)tCc>tAc	p.S483Y	WNK3_ENST00000375159.2_Missense_Mutation_p.S483Y|WNK3_ENST00000375169.3_Missense_Mutation_p.S483Y	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	483					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						GTCTCTAATGGATTTAGCAAC	0.403000													22	20					4.81078e-24	6.13913e-24	0.076483	1	0
ASGR2	433	broad.mit.edu	37	17	7004973	7004973	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:7004973C>T	ENST00000380952.2	-	9	1121	c.857G>A	c.(856-858)cGc>cAc	p.R286H	ASGR2_ENST00000446679.2_Missense_Mutation_p.R267H|ASGR2_ENST00000355035.5_Missense_Mutation_p.R286H|ASGR2_ENST00000254850.7_Missense_Mutation_p.R262H	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	286	C-type lectin.				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	ATCGTTCCAGCGGCCATCCGG	0.592000													89	7					0	0	0.139131	0	0
CDCA2	157313	broad.mit.edu	37	8	25346171	25346171	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:25346171A>G	ENST00000330560.3	+	13	2114	c.1637A>G	c.(1636-1638)aAg>aGg	p.K546R	CDCA2_ENST00000380665.3_Missense_Mutation_p.K531R|CDCA2_ENST00000521098.2_3'UTR	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	546	Lys-rich.				cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		CAAGAAACAAAGTGTACAAAG	0.338000													41	60					0	0	0.124865	0	0
SBSPON	157869	broad.mit.edu	37	8	74005206	74005206	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:74005206C>A	ENST00000297354.6	-	1	301	c.97G>T	c.(97-99)Gac>Tac	p.D33Y	SBSPON_ENST00000519697.1_Intron	NM_153225.3	NP_694957.3	Q8IVN8	RPESP_HUMAN	somatomedin B and thrombospondin, type 1 domain containing	33	SMB.				immune response	extracellular region	polysaccharide binding|scavenger receptor activity										CAGGCGGGGTCCCGGCCGGGA	0.731000													3	3					5.18039e-06	5.82794e-06	0.038147	1	0
NAALADL2	254827	broad.mit.edu	37	3	174814953	174814953	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:174814953G>A	ENST00000454872.1	+	2	545	c.417G>A	c.(415-417)ggG>ggA	p.G139G	NAALADL2-AS3_ENST00000453180.1_RNA|NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	139					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TTATTTTTGGGATTTTGATAG	0.373000													50	185					0	0	0.139131	0	0
MYO1F	4542	broad.mit.edu	37	19	8595413	8595413	+	Silent	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:8595413A>G	ENST00000338257.8	-	20	2355	c.2088T>C	c.(2086-2088)ttT>ttC	p.F696F		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	696	IQ.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TGGTTCGGGCAAAGCCATCGA	0.657000													92	111					0	0	0.139131	0	0
LRRC7	57554	broad.mit.edu	37	1	70300480	70300480	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:70300480C>G	ENST00000310961.5	+	7	837	c.419C>G	c.(418-420)aCa>aGa	p.T140R	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000370958.1_Missense_Mutation_p.T173R|LRRC7_ENST00000035383.5_Missense_Mutation_p.T135R			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	135						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GATGGCTTCACACAGCTCCTA	0.358000													39	7					0	0	0.098360	0	0
PKD2	5311	broad.mit.edu	37	4	88996775	88996775	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:88996775C>T	ENST00000237596.2	+	15	2902	c.2836C>T	c.(2836-2838)Cca>Tca	p.P946S	PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000508588.1_Missense_Mutation_p.P364S|PKD2_ENST00000502363.1_Missense_Mutation_p.P364S	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	946	C-terminal coiled coil domain.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		AAGCTCCCGCCCATCTTCCTC	0.502000													5	99					0	0	0.029380	0	0
TCF15	6939	broad.mit.edu	37	20	590588	590588	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:590588G>A	ENST00000246080.3	-	1	454	c.294C>T	c.(292-294)ctC>ctT	p.L98L		NM_004609.3	NP_004600.2	Q12870	TCF15_HUMAN	transcription factor 15 (basic helix-loop-helix)	98	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|lung(2)|prostate(1)	4		Breast(17;0.231)				CGGTGGGGATGAGCGTGCGCA	0.716000													4	2					0	0	0.150653	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3982	3982	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrM:3982G>A	ENST00000361390.2	+	1	676	c.676G>A	c.(676-678)Gcc>Acc	p.226_226insT						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						TATTCTTCATAGCCGAATACA	0.478000													63	376					0	0	0.139131	0	0
DLG2	1740	broad.mit.edu	37	11	83544765	83544765	+	Silent	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:83544765G>A	ENST00000398309.2	-	12	1769	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F	DLG2_ENST00000532653.1_Silent_p.F433F|DLG2_ENST00000418306.2_Silent_p.F330F|DLG2_ENST00000537455.1_Silent_p.F187F|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000543673.1_Silent_p.F538F|DLG2_ENST00000398301.2_Silent_p.F472F|DLG2_ENST00000280241.8_Silent_p.F472F|DLG2_ENST00000524982.1_Silent_p.F433F|DLG2_ENST00000531015.1_Silent_p.F400F|DLG2_ENST00000376104.2_Silent_p.F538F|DLG2_ENST00000330014.6_Silent_p.F372F	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	433	PDZ 3.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CGACAATGTTGAAGCCCAGGC	0.507000													41	54					0	0	0.117977	0	0
ZBTB40	9923	broad.mit.edu	37	1	22852714	22852714	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:22852714C>T	ENST00000404138.1	+	19	4056	c.3545C>T	c.(3544-3546)cCg>cTg	p.P1182L	ZBTB40_ENST00000374651.4_Missense_Mutation_p.P1070L|ZBTB40_ENST00000375647.4_Missense_Mutation_p.P1182L	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1182					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		ACCCCAGAGCCGGTGGCCCCG	0.562000													12	12					0	0	0.119110	0	0
NSDHL	50814	broad.mit.edu	37	X	152031185	152031185	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:152031185G>A	ENST00000370274.3	+	5	654	c.460G>A	c.(460-462)Gat>Aat	p.D154N	NSDHL_ENST00000440023.1_Missense_Mutation_p.D154N	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	154					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	TGAGGGCGTCGATATCAAGAA	0.408000													53	68					0	0	0.139131	0	0
C10orf71	118461	broad.mit.edu	37	10	50532448	50532448	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:50532448G>T	ENST00000374144.3	+	3	2146	c.1858G>T	c.(1858-1860)Gaa>Taa	p.E620*	C10orf71_ENST00000323868.4_Nonsense_Mutation_p.E620*			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	620										endometrium(1)	1						CAAGGAGGTGGAAGGAGAGTT	0.552000													17	19					2.94398e-08	3.47187e-08	0.189662	1	0
ERGIC3	51614	broad.mit.edu	37	20	34130126	34130126	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:34130126A>G	ENST00000348547.2	+	2	220	c.143A>G	c.(142-144)tAt>tGt	p.Y48C	ERGIC3_ENST00000357394.4_Missense_Mutation_p.Y48C|ERGIC3_ENST00000279052.6_Missense_Mutation_p.Y48C|ERGIC3_ENST00000447986.1_Missense_Mutation_p.Y48C	NM_015966.2	NP_057050.1	Q9Y282	ERGI3_HUMAN	ERGIC and golgi 3	48					vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)	16	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GAGCTGCAGTATTACCTCACC	0.597000													13	33					0	0	0.119110	0	0
RP4-683M8.2	0	broad.mit.edu	37	1	48521228	48521229	+	RNA	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:48521228_48521229insG	ENST00000439795.1	+	0	185																											GGCAAGGCAGTGGGGGGCACTG	0.584													2	4	---	---	---	---					
RP4-683M8.2	0	broad.mit.edu	37	1	48530542	48530545	+	RNA	DEL	ATCC	ATCC	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:48530542_48530545delATCC	ENST00000439795.1	+	0	185																											ccatccatctatccatccatccat	0.485													2	4	---	---	---	---					
LOC101927587	101927587	broad.mit.edu	37	1	84077028	84077029	+	RNA	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:84077028_84077029insC	ENST00000417975.1	-	0	280																											gggggaaaccacccccatgatc	0.446													2	4	---	---	---	---					
LOC101927587	101927587	broad.mit.edu	37	1	84247695	84247696	+	RNA	INS	-	-	G	rs78417642	byFrequency	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:84247695_84247696insG	ENST00000417975.1	-	0	178																											ggatttttactggggggctagt	0.406													2	4	---	---	---	---					
RP5-965F6.2	0	broad.mit.edu	37	1	112852590	112852590	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:112852590delC	ENST00000427290.1	-	0	167																											GATGCTCCTGCCCTCAGAGAG	0.493													2	4	---	---	---	---					
RP11-417J8.1	0	broad.mit.edu	37	1	142556066	142556067	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:142556066_142556067insT	ENST00000445662.1	+	0	204																											Tttttcttttctttttttcttt	0.351													4	5	---	---	---	---					
RP11-423O2.7	0	broad.mit.edu	37	1	142956513	142956514	+	RNA	DEL	CT	CT	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:142956513_142956514delCT	ENST00000424640.2	-	0	202_203																											ttagaacttactgtgttccagg	0.302													2	4	---	---	---	---					
PDE4DIP	9659	broad.mit.edu	37	1	145014187	145014188	+	Frame_Shift_Del	DEL	AA	AA	-	rs142142861		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:145014187_145014188delAA	ENST00000493130.2	-	4	515_516	c.354_355delTT	c.(352-357)ttcafs	p.FS118fs	PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000530740.1_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCAAAAGGTGAAAAAAAAAAAA	0.505			T	PDGFRB	MPD								3	3	---	---	---	---					
RP1-35C21.2	0	broad.mit.edu	37	1	177494798	177494799	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:177494798_177494799insT	ENST00000438575.1	-	0	296																											TTCATGGATAGTTTTTTTTCTG	0.342													2	4	---	---	---	---					
TROVE2	6738	broad.mit.edu	37	1	193038460	193038461	+	Frame_Shift_Ins	INS	-	-	CTCT			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:193038460_193038461insCTCT	ENST00000367446.3	+	2	486_487	c.276_277insCTCT	c.(274-279)attcttfs	p.L93fs	TROVE2_ENST00000367445.3_Frame_Shift_Ins_p.L93fs|TROVE2_ENST00000432079.1_Intron|TROVE2_ENST00000367443.1_Frame_Shift_Ins_p.L93fs|TROVE2_ENST00000400968.2_Frame_Shift_Ins_p.L93fs|TROVE2_ENST00000416058.2_5'UTR|TROVE2_ENST00000367444.3_Frame_Shift_Ins_p.L93fs|TROVE2_ENST00000460715.2_Intron|TROVE2_ENST00000367441.1_Frame_Shift_Ins_p.L93fs	NM_004600.5	NP_004591.2	P10155	RO60_HUMAN	TROVE domain family, member 2	93	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						AAGAGCCTATGCTCTTTGCACT	0.401													13	35	---	---	---	---					
LINC01221	104266961	broad.mit.edu	37	1	199043197	199043198	+	RNA	DEL	GT	GT	-	rs71150944		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:199043197_199043198delGT	ENST00000432488.1	+	0	450																											ttgagtgtgagtgtgtgtgtgt	0.342													2	4	---	---	---	---					
RP11-177F15.1	0	broad.mit.edu	37	1	238687752	238687752	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:238687752delT	ENST00000442726.1	+	0	216																											TAATGAGAGATTTCCAAAAAT	0.358													2	4	---	---	---	---					
LOC102724446	102724446	broad.mit.edu	37	1	247764450	247764455	+	RNA	DEL	ACACAC	ACACAC	-	rs71658891		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr1:247764450_247764455delACACAC	ENST00000435333.1	-	0	225				RP11-978I15.10_ENST00000446347.1_RNA																							taaaaGGTAAacacacacacacacac	0.408													4	6	---	---	---	---					
LOC400940	400940	broad.mit.edu	37	2	6094685	6094686	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:6094685_6094686insT	ENST00000431188.1	+	0	134																											aagagatgcagttttttggctt	0.366													2	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12494005	12494005	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:12494005delC	ENST00000412294.1	+	0	412																											TCCCGTTTTTCTTGTCTAGAT	0.308													2	4	---	---	---	---					
AC010967.2	0	broad.mit.edu	37	2	53027359	53027359	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:53027359delT	ENST00000421575.1	-	0	119																											actttgctcctatagtaactt	0.378													2	4	---	---	---	---					
TET3	200424	broad.mit.edu	37	2	74326442	74326442	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr2:74326442delA	ENST00000409262.3	+	8	2902	c.2902delA	c.(2902-2904)agfs	p.K968fs		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	968							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTGCGTGGGCAAGATTCCCGA	0.592													10	11	---	---	---	---					
AC018359.1	0	broad.mit.edu	37	3	34562679	34562679	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:34562679delT	ENST00000424786.1	+	0	570																											ggttgggggcttttggcccag	0.537													2	4	---	---	---	---					
RP11-359D24.1	0	broad.mit.edu	37	3	81917503	81917506	+	RNA	DEL	TATC	TATC	-	rs71950010		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:81917503_81917506delTATC	ENST00000471614.1	+	0	363																											CTGCATGTTAtatctatctatcta	0.304													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82314602	82314602	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:82314602delT	ENST00000470263.1	+	0	472																											TGCTGGTCGATTTTTTTTTTT	0.348													2	4	---	---	---	---					
RP11-325B23.2	0	broad.mit.edu	37	3	98132166	98132166	+	RNA	DEL	A	A	-	rs147014392		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:98132166delA	ENST00000508616.1	+	0	188																											ggatctaattaaaagaccttc	0.358													5	2	---	---	---	---					
LINC00882	100302640	broad.mit.edu	37	3	106884166	106884166	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:106884166delC	ENST00000484698.1	-	0	190																											aggatatcatccatgagaatt	0.388													2	4	---	---	---	---					
LINC00636	285205	broad.mit.edu	37	3	107640176	107640177	+	RNA	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:107640176_107640177insG	ENST00000494231.1	+	0	59					NR_015394.1																						CCTCTGCACCCGGGGAGTGGGT	0.500													4	7	---	---	---	---					
RP11-572M11.4	0	broad.mit.edu	37	3	112805893	112805894	+	RNA	INS	-	-	AC	rs146100738	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:112805893_112805894insAC	ENST00000460707.1	+	0	390				RP11-572M11.4_ENST00000470313.1_RNA|RP11-572M11.4_ENST00000496389.1_RNA|RP11-572M11.4_ENST00000467342.1_RNA																							CTACTCCCCCAacacacacaca	0.460													4	2	---	---	---	---					
ZBTB38	253461	broad.mit.edu	37	3	141065624	141065625	+	RNA	INS	-	-	TGTG	rs150173767	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:141065624_141065625insTGTG	ENST00000507698.1	-	0	166																											TTGTTTTGTTTtgtgtgtgtgt	0.480													5	4	---	---	---	---					
RP11-501O2.3	0	broad.mit.edu	37	3	147889915	147889915	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:147889915delA	ENST00000477153.1	+	0	166																											aataaaaaccaaaaaAAATAG	0.254													4	3	---	---	---	---					
RP11-501O2.5	0	broad.mit.edu	37	3	148051913	148051914	+	RNA	INS	-	-	C	rs73011660	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:148051913_148051914insC	ENST00000481334.1	+	0	106																											ccctcccctcgcccccccaaca	0.500													2	4	---	---	---	---					
RP11-167H9.4	0	broad.mit.edu	37	3	149775393	149775393	+	RNA	DEL	A	A	-	rs111923176		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:149775393delA	ENST00000487840.1	+	0	46																											AATCACCTGCAAAAAAAAAAA	0.468													3	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153328545	153328545	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:153328545delT	ENST00000493214.2	-	0	160																											ttgatcactgttttttttttt	0.388													3	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153506699	153506700	+	RNA	INS	-	-	T	rs35878056	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:153506699_153506700insT	ENST00000488210.1	-	0	477																											ttttatttttattttttttttg	0.416													4	3	---	---	---	---					
RP11-217E22.5	0	broad.mit.edu	37	3	153646356	153646357	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:153646356_153646357insT	ENST00000463297.1	+	0	144				RP11-23D24.2_ENST00000488210.1_RNA																							TAGCATTTATATTTTTCAGGCA	0.322													2	4	---	---	---	---					
LINC01324	104355289	broad.mit.edu	37	3	164436824	164436825	+	RNA	DEL	TG	TG	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:164436824_164436825delTG	ENST00000497379.2	-	0	236																											ATTGTGATATTGTGTGTGTGTG	0.337													2	4	---	---	---	---					
TMEM212-AS1	100874219	broad.mit.edu	37	3	171611485	171611486	+	RNA	INS	-	-	CA	rs71178244		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:171611485_171611486insCA	ENST00000449106.1	-	0	382																											TCTCTCTCTCTCTcacacacac	0.421													3	4	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172984726	172984726	+	RNA	DEL	T	T	-	rs35204060		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:172984726delT	ENST00000447709.1	+	0	216																											tagttcttagtttttctctta	0.393													6	2	---	---	---	---					
HTR3C	170572	broad.mit.edu	37	3	183777416	183777417	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:183777416_183777417insC	ENST00000318351.1	+	7	947_948	c.913_914insC	c.(913-915)cccfs	p.P305fs		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	305						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGCCAGTGGCACCCCCCTCATC	0.584													9	406	---	---	---	---					
EHHADH-AS1	339926	broad.mit.edu	37	3	184882904	184882905	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:184882904_184882905insA	ENST00000417720.1	+	0	84				EHHADH-AS1_ENST00000444571.1_RNA	NR_038990.1																						TTAGTGGTATGAAGGGAAATTG	0.436													2	4	---	---	---	---					
SDHAP1	255812	broad.mit.edu	37	3	195713385	195713386	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr3:195713385_195713386insT	ENST00000427841.1	-	0	176					NR_003264.2																						AAAGCATGAACTTACGGAATCT	0.401													3	6	---	---	---	---					
STX18-AS1	100507266	broad.mit.edu	37	4	4569478	4569479	+	RNA	INS	-	-	T	rs147903217		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:4569478_4569479insT	ENST00000502693.1	+	0	357				STX18-AS1_ENST00000512438.1_RNA																							GCAATAGGTACttttttttttt	0.436													6	2	---	---	---	---					
LINC01182	101929071	broad.mit.edu	37	4	13752854	13752855	+	RNA	DEL	AG	AG	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:13752854_13752855delAG	ENST00000510907.1	+	0	281																											agtagggggcagagagagagag	0.366													2	4	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14658780	14658781	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:14658780_14658781insT	ENST00000505089.1	-	0	224																											tataaaacttcttttttttttt	0.356													2	4	---	---	---	---					
RP11-380P13.1	0	broad.mit.edu	37	4	23565522	23565523	+	RNA	INS	-	-	GT	rs149128826	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:23565522_23565523insGT	ENST00000514290.1	+	0	117																											TATATATATAAgtgtgtgtgtg	0.396													4	3	---	---	---	---					
LOC102723828	102723828	broad.mit.edu	37	4	32122564	32122564	+	RNA	DEL	C	C	-	rs10600653		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:32122564delC	ENST00000513211.1	+	0	426																											cacacacacacaaacacaTGA	0.433													6	0	---	---	---	---					
RP11-213G21.2	0	broad.mit.edu	37	4	38567856	38567857	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:38567856_38567857insA	ENST00000512170.1	+	0	114																											ACAGCAAAAAGAAAAAAAAATC	0.302													2	4	---	---	---	---					
RP11-227F19.1	0	broad.mit.edu	37	4	41825720	41825720	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:41825720delA	ENST00000508038.1	+	0	671																											actctgtctcaaaaaaaaaaa	0.403													2	4	---	---	---	---					
LINC01088	100505875	broad.mit.edu	37	4	80113387	80113388	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:80113387_80113388insT	ENST00000509088.1	+	0	349				RP11-438E5.1_ENST00000510667.1_RNA|RP11-438E5.1_ENST00000513153.1_RNA	NR_038342.1																						gtcattgataattttttttttg	0.356													2	4	---	---	---	---					
RP11-742B18.1	0	broad.mit.edu	37	4	88492755	88492756	+	RNA	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:88492755_88492756insC	ENST00000506480.1	-	0	322																											tgtatccctcacccccctctca	0.431													3	6	---	---	---	---					
LOC101927282	101927282	broad.mit.edu	37	4	130676142	130676142	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:130676142delA	ENST00000500092.2	-	0	67																											aggggctctgaaaacagggag	0.428													2	4	---	---	---	---					
RP11-242J7.1	0	broad.mit.edu	37	4	185540804	185540804	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr4:185540804delA	ENST00000522554.1	-	0	292																											taaagatggcaaaaacaccac	0.448													2	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3446119	3446120	+	RNA	INS	-	-	TGA	rs139792392	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:3446119_3446120insTGA	ENST00000505443.1	-	0	459					NR_033898.1																						ggtggtgatggtgatgatgatg	0.515													9	11	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	7113031	7113032	+	RNA	INS	-	-	ACAC	rs10535896	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:7113031_7113032insACAC	ENST00000512838.1	+	0	154																											TCACACATGGGacacacacaca	0.332													8	11	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9780785	9780786	+	RNA	INS	-	-	TGTGTG	rs141409616	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:9780785_9780786insTGTGTG	ENST00000511616.1	-	0	521					NR_027112.2																						aactaacagaatgtgtgtgtgt	0.391													7	11	---	---	---	---					
TRIO	7204	broad.mit.edu	37	5	14387626	14387627	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:14387626_14387627insA	ENST00000344204.4	+	22	3674_3675	c.3650_3651insA	c.(3649-3651)aaafs	p.K1217fs	TRIO_ENST00000537187.1_Frame_Shift_Ins_p.K1217fs|TRIO_ENST00000509967.2_Frame_Shift_Ins_p.K1168fs	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1217					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GCGGCAGAGATAAAAAAATGTG	0.446													8	522	---	---	---	---					
CTD-2023M8.1	0	broad.mit.edu	37	5	18706693	18706694	+	RNA	DEL	GT	GT	-	rs35354602		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:18706693_18706694delGT	ENST00000512978.1	-	0	176																											gtttgtgtgagtgtgtgtgtgt	0.366													2	4	---	---	---	---					
RP11-774D14.1	0	broad.mit.edu	37	5	20689885	20689886	+	RNA	INS	-	-	A	rs72345463		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:20689885_20689886insA	ENST00000502427.1	+	0	248																											aaaaaaaaaagaaaaaaaaaaa	0.347													5	3	---	---	---	---					
RP11-774D14.1	0	broad.mit.edu	37	5	20737648	20737649	+	RNA	INS	-	-	A	rs78122911	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:20737648_20737649insA	ENST00000502427.1	+	0	395																											CATCTGTATGCAAAAAAAAATG	0.302													7	3	---	---	---	---					
RP11-804N13.1	0	broad.mit.edu	37	5	21623882	21623883	+	RNA	INS	-	-	T	rs34222912		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:21623882_21623883insT	ENST00000522350.1	+	0	336																											tcagccccaacttttttttttt	0.312													5	3	---	---	---	---					
NIPBL	25836	broad.mit.edu	37	5	36986119	36986120	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:36986119_36986120insG	ENST00000282516.8	+	10	3336_3337	c.2837_2838insG	c.(2836-2838)tggfs	p.W946fs	NIPBL_ENST00000504430.1_3'UTR|NIPBL_ENST00000448238.2_Frame_Shift_Ins_p.W946fs	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	946					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGTTATTTGTTGGGGGGCAGGT	0.391													11	543	---	---	---	---					
CTD-2337A12.1	0	broad.mit.edu	37	5	95557863	95557864	+	RNA	INS	-	-	A	rs79870152		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:95557863_95557864insA	ENST00000511775.1	+	0	35				CTD-2337A12.1_ENST00000502645.2_RNA																							aaaactactagaaaaaaccata	0.337													2	4	---	---	---	---					
RP11-492A10.1	0	broad.mit.edu	37	5	113879838	113879839	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:113879838_113879839insA	ENST00000514115.1	-	0	331																											gcctactaaccaaaaaaacttc	0.361													2	4	---	---	---	---					
DND1	373863	broad.mit.edu	37	5	140052285	140052285	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr5:140052285delT	ENST00000542735.1	-	3	392	c.349delA	c.(349-351)cgfs	p.T117fs		NM_194249.2	NP_919225.1	Q8IYX4	DND1_HUMAN	DND microRNA-mediated repression inhibitor 1	117	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding	p.T117fs*24(1)		central_nervous_system(1)|prostate(4)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGCAGCGTGGCGATGGCG	0.682													5	4	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6513434	6513435	+	RNA	DEL	CA	CA	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:6513434_6513435delCA	ENST00000435641.1	-	0	482				LY86-AS1_ENST00000429345.1_RNA|LY86-AS1_ENST00000447858.1_RNA																							ggtaattcttcacctttcttct	0.470													6	1	---	---	---	---					
RP1-45N11.1	0	broad.mit.edu	37	6	91069555	91069556	+	RNA	DEL	GT	GT	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:91069555_91069556delGT	ENST00000569865.1	+	0	687																											GGGGAGGGTGgtgtgtgtgtgt	0.530													3	5	---	---	---	---					
LOC101927640	101927640	broad.mit.edu	37	6	112629375	112629376	+	RNA	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:112629375_112629376insC	ENST00000587816.1	+	0	111				RP11-506B6.6_ENST00000590673.1_RNA|RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA																							ATTTCTCACTGCCCCCCCTTCC	0.535													2	4	---	---	---	---					
RP11-138M12.1	0	broad.mit.edu	37	6	125758751	125758752	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:125758751_125758752insA	ENST00000430672.1	-	0	162																											tgctagaaaggaaaaaaaaaaa	0.391													2	4	---	---	---	---					
RP13-143G15.4	0	broad.mit.edu	37	6	136534966	136534967	+	RNA	DEL	AC	AC	-	rs72041089		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:136534966_136534967delAC	ENST00000417643.1	-	0	58																											AACCCCGCAGacacacacacac	0.520													2	4	---	---	---	---					
LOC153910	153910	broad.mit.edu	37	6	142916754	142916755	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:142916754_142916755insA	ENST00000447311.1	-	0	177					NR_027312.1																						aaacagttcagaaaaaaaatta	0.302													2	4	---	---	---	---					
STXBP5-AS1	729178	broad.mit.edu	37	6	147299724	147299725	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr6:147299724_147299725insT	ENST00000367477.3	-	0	669				STXBP5-AS1_ENST00000447072.1_RNA|STXBP5-AS1_ENST00000427394.1_RNA|STXBP5-AS1_ENST00000431143.1_RNA|STXBP5-AS1_ENST00000458125.1_RNA																							ttgatttTGGAGGGGTAAGGCT	0.401													2	4	---	---	---	---					
AC004009.3	0	broad.mit.edu	37	7	27433062	27433062	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:27433062delT	ENST00000412413.1	+	0	278																											AAAGTCCACCTTTTCTCTAGC	0.448													2	4	---	---	---	---					
GARS	2617	broad.mit.edu	37	7	30634583	30634585	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:30634583_30634585delCTG	ENST00000389266.3	+	1	287_289	c.46_48delCTG	c.(46-48)del	p.L20del		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	20					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	TCGCGCCGCTCTGCTGCTGCTGC	0.749													3	6	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34430813	34430813	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:34430813delT	ENST00000419766.1	-	0	404					NR_033664.1|NR_033665.1																						tctttctttcttttctttctt	0.308													2	4	---	---	---	---					
RP11-3P22.2	0	broad.mit.edu	37	7	68798992	68798992	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:68798992delT	ENST00000435148.1	-	0	156																											CTAAAtttccttttttttttt	0.448													3	4	---	---	---	---					
AC003988.1	0	broad.mit.edu	37	7	79920087	79920088	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:79920087_79920088insA	ENST00000447198.2	-	0	202																											gattttaagacaaaaactataa	0.317													2	4	---	---	---	---					
COL26A1	136227	broad.mit.edu	37	7	101045642	101045642	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:101045642delA	ENST00000313669.7	+	0	350				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GGAGGAAATTAAAAGcaggaa	0.547													2	4	---	---	---	---					
RP5-921G16.1	0	broad.mit.edu	37	7	123900248	123900249	+	RNA	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr7:123900248_123900249insG	ENST00000484322.1	+	0	168																											aggtgattggaggggggcaata	0.416													2	4	---	---	---	---					
RP11-145O15.3	0	broad.mit.edu	37	8	13447814	13447814	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:13447814delT	ENST00000529018.1	-	0	74																											acatccccagtttttttttgc	0.408													2	4	---	---	---	---					
RP11-108E14.1	0	broad.mit.edu	37	8	20515578	20515579	+	RNA	INS	-	-	TTTG	rs3044006	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:20515578_20515579insTTTG	ENST00000517706.1	-	0	195																											gctaccaactttttgtttgttt	0.460													3	5	---	---	---	---					
RP11-459E5.1	0	broad.mit.edu	37	8	22556036	22556036	+	RNA	DEL	T	T	-	rs113414402		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:22556036delT	ENST00000523627.1	+	0	164																											aattaaaaacttttttttttt	0.473													3	3	---	---	---	---					
RP11-11N9.4	0	broad.mit.edu	37	8	32883715	32883715	+	RNA	DEL	T	T	-	rs112794036		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:32883715delT	ENST00000500843.2	+	0	139																											catatgatgattttttttttt	0.358													2	4	---	---	---	---					
LOC100505739	100505739	broad.mit.edu	37	8	70353889	70353890	+	RNA	DEL	GC	GC	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:70353889_70353890delGC	ENST00000517343.1	-	0	374																											CTCCTAACATGCGCGCGCGCGc	0.446													5	3	---	---	---	---					
RP11-326E22.1	0	broad.mit.edu	37	8	72093875	72093875	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:72093875delT	ENST00000521685.1	+	0	270																											ACACCACTGGTGGGCTATTCC	0.478													2	4	---	---	---	---					
ZFHX4-AS1	100192378	broad.mit.edu	37	8	77560646	77560646	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:77560646delG	ENST00000518143.1	-	0	434				ZFHX4-AS1_ENST00000522961.1_RNA	NR_024360.1																						agacttgcatggggcctgtag	0.423													3	4	---	---	---	---					
RP11-941H19.3	0	broad.mit.edu	37	8	81192735	81192736	+	RNA	INS	-	-	A	rs144312229	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:81192735_81192736insA	ENST00000522044.1	+	0	218																											tcgtgtgtgggaagcctttggg	0.396													4	3	---	---	---	---					
LOC101927141	101927141	broad.mit.edu	37	8	83873631	83873632	+	RNA	DEL	TT	TT	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:83873631_83873632delTT	ENST00000524359.1	+	0	474																											cctctccatctttttttttttt	0.431													2	4	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89435800	89435800	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:89435800delA	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							TAGAGTAAAGAAAAAAAAAAT	0.294													2	4	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89633702	89633702	+	RNA	DEL	A	A	-	rs11323617		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:89633702delA	ENST00000521433.1	+	0	310				RP11-586K2.1_ENST00000520312.1_RNA|RP11-586K2.1_ENST00000518631.1_RNA																							accctgtctcaaaaaaaaaaa	0.378													3	6	---	---	---	---					
LOC101929709	101929709	broad.mit.edu	37	8	90757022	90757023	+	RNA	DEL	CA	CA	-	rs79124550		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:90757022_90757023delCA	ENST00000504145.1	-	0	667																											ttaattgactcacagttccaca	0.441													3	4	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91310319	91310319	+	RNA	DEL	A	A	-	rs71510462		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:91310319delA	ENST00000523406.1	+	0	300					NR_051989.1																						gtgtttacacaagccacaccg	0.527													3	4	---	---	---	---					
FLJ46284	441369	broad.mit.edu	37	8	93872675	93872676	+	RNA	DEL	AC	AC	-	rs34010842		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:93872675_93872676delAC	ENST00000504861.2	-	0	55					NR_046114.1																						acacacacatacacacacacac	0.411													3	4	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94464483	94464484	+	RNA	DEL	AC	AC	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:94464483_94464484delAC	ENST00000501400.1	-	0	1133					NR_033858.1																						CTacacacatacacacacacac	0.366													2	4	---	---	---	---					
RP11-211F2.1	0	broad.mit.edu	37	8	111357946	111357946	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:111357946delG	ENST00000522896.1	-	0	63																											tttagtacctgggtgattaaa	0.413													2	4	---	---	---	---					
RP11-96B2.1	0	broad.mit.edu	37	8	123497754	123497754	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:123497754delT	ENST00000530350.2	-	0	630																											atagcaccacttttttttttc	0.418													4	6	---	---	---	---					
ZHX2	22882	broad.mit.edu	37	8	123965335	123965336	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:123965335_123965336insC	ENST00000314393.4	+	3	2420_2421	c.1585_1586insC	c.(1585-1587)cccfs	p.P529fs		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	529						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CCCAGACTTTGCCCCCCAGAAG	0.515													7	141	---	---	---	---					
CTD-2552K11.2	0	broad.mit.edu	37	8	124630233	124630233	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:124630233delA	ENST00000524355.1	+	0	169				CTD-2552K11.2_ENST00000518633.1_RNA																							AACTGCCAACAAGGGTTAGGA	0.478													2	4	---	---	---	---					
RP11-136O12.2	0	broad.mit.edu	37	8	126535884	126535885	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:126535884_126535885insA	ENST00000521991.1	+	0	239																											cttcttatatgaaaaaaacgta	0.411													2	4	---	---	---	---					
CASC8	727677	broad.mit.edu	37	8	128461896	128461896	+	RNA	DEL	A	A	-	rs10719294		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:128461896delA	ENST00000502082.1	-	0	1041				CASC8_ENST00000502056.1_RNA																							ACTGAGGCCCAAAAAAATGTG	0.453													5	6	---	---	---	---					
RP11-513H8.1	0	broad.mit.edu	37	8	135287229	135287230	+	RNA	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr8:135287229_135287230insG	ENST00000523317.1	-	0	84																											GGAAACATGGCGGGGGGGGTCA	0.421													2	4	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68402732	68402733	+	RNA	INS	-	-	TGAAT			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr9:68402732_68402733insTGAAT	ENST00000417843.2	-	0	224																											ATCTCACATGATGAAGACTAAA	0.287													2	4	---	---	---	---					
RP11-281A20.2	0	broad.mit.edu	37	9	120601067	120601067	+	RNA	DEL	A	A	-	rs151225086		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr9:120601067delA	ENST00000421509.2	+	0	121																											actccatctcaaaaaaaaaaa	0.468													2	4	---	---	---	---					
RP11-65J3.3	0	broad.mit.edu	37	9	132197734	132197735	+	RNA	INS	-	-	TC	rs72061559	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr9:132197734_132197735insTC	ENST00000436510.1	-	0	487																											CGCCGTCGGAGTCAGCCTCGGA	0.574													12	1	---	---	---	---					
ANTXRLP1	100996567	broad.mit.edu	37	10	47639410	47639411	+	RNA	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:47639410_47639411insC	ENST00000454837.1	-	0	192					NR_103827.1																						atgcatatatgccccctacaca	0.545													2	4	---	---	---	---					
LINC00595	414243	broad.mit.edu	37	10	80050956	80050957	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:80050956_80050957insT	ENST00000461034.1	+	0	108																											gggcaaagtgatttttccaaga	0.450													2	4	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125116018	125116018	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:125116018delC	ENST00000448347.1	+	0	53																											GAGTGAAATTCCCCAGACAAT	0.468													6	1	---	---	---	---					
LINC01166	101927590	broad.mit.edu	37	10	134772720	134772721	+	RNA	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr10:134772720_134772721insG	ENST00000443633.1	-	0	104																											CTGGACCCCCATCCTCTGACGG	0.604													2	4	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28933002	28933003	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:28933002_28933003insT	ENST00000513853.1	+	0	304																											aatttagtcacttttTTTTTCT	0.351													2	4	---	---	---	---					
RP11-563P16.1	0	broad.mit.edu	37	11	103717077	103717078	+	RNA	INS	-	-	TCCCTCCCTCTC			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:103717077_103717078insTCCCTCCCTCTC	ENST00000533459.1	-	0	127																											ccttccctccttccctccctct	0.436													3	2	---	---	---	---					
RP11-708B6.2	0	broad.mit.edu	37	11	109406506	109406507	+	RNA	DEL	CA	CA	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:109406506_109406507delCA	ENST00000532929.1	-	0	117				RP11-708B6.2_ENST00000532992.1_RNA																							cccttttctccacactctcacc	0.376													2	4	---	---	---	---					
LOC283140	283140	broad.mit.edu	37	11	112225585	112225585	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:112225585delT	ENST00000504610.2	+	0	238																											tgtgggttgcttttgtgggGt	0.458													2	4	---	---	---	---					
USP2-AS1	100499227	broad.mit.edu	37	11	119317592	119317592	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr11:119317592delG	ENST00000498979.2	+	0	273				USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000500970.1_RNA|USP2-AS1_ENST00000578923.1_RNA	NR_034160.1																						GGCCTGGAATGGGGTGGGGTC	0.468													2	4	---	---	---	---					
LINC00940	100271702	broad.mit.edu	37	12	2042156	2042157	+	RNA	INS	-	-	GT	rs58380439		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:2042156_2042157insGT	ENST00000418006.1	-	0	121					NR_036546.1																						cgtatgtgtacgtgtgaatgta	0.416													2	4	---	---	---	---					
LINC00940	100271702	broad.mit.edu	37	12	2042172	2042173	+	RNA	INS	-	-	GT	rs60155375		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:2042172_2042173insGT	ENST00000418006.1	-	0	121					NR_036546.1																						aatgtatgtgcatatgtttgtg	0.416													4	3	---	---	---	---					
LOC101928162	101928162	broad.mit.edu	37	12	10907250	10907250	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:10907250delA	ENST00000541949.1	+	0	67																											ggtggcaggcaaaaagagttt	0.458													2	4	---	---	---	---					
RP11-711K1.8	0	broad.mit.edu	37	12	11387578	11387579	+	RNA	INS	-	-	T	rs67393401		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:11387578_11387579insT	ENST00000539328.1	+	0	435																											GTGTTTTGTTGttttttttttt	0.411													4	2	---	---	---	---					
FLJ12825	440101	broad.mit.edu	37	12	54497545	54497546	+	RNA	INS	-	-	T	rs144888465	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:54497545_54497546insT	ENST00000515617.1	+	0	311					NR_026655.1																						ctgttctcttctgaatgccctt	0.525													8	0	---	---	---	---					
RP11-123O10.4	0	broad.mit.edu	37	12	67386164	67386164	+	RNA	DEL	T	T	-	rs58864073		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:67386164delT	ENST00000535721.1	-	0	113																											aaaaaaaaaatttttttttaa	0.343													6	0	---	---	---	---					
RP11-54A9.1	0	broad.mit.edu	37	12	76655658	76655658	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:76655658delC	ENST00000553247.1	+	0	77																											tttcctttttccagatctact	0.378													2	4	---	---	---	---					
RP11-148B3.2	0	broad.mit.edu	37	12	116814922	116814922	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr12:116814922delG	ENST00000548506.1	+	0	74																											GAGTAACAGTGGGTAAAAGTT	0.562													2	4	---	---	---	---					
TUBA3C	7278	broad.mit.edu	37	13	19751596	19751597	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr13:19751596_19751597insG	ENST00000400113.3	-	4	630_631	c.526_527insC	c.(526-528)ggtfs	p.G176fs		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	176					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CGTGGAGACCTGGGGGGCTGGG	0.574													7	215	---	---	---	---					
CHD8	57680	broad.mit.edu	37	14	21896303	21896304	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:21896303_21896304insC	ENST00000399982.2	-	3	1389_1390	c.1325_1326insG	c.(1324-1326)gaafs	p.E442fs	CHD8_ENST00000555962.1_Intron|CHD8_ENST00000557364.1_Frame_Shift_Ins_p.E442fs|CHD8_ENST00000430710.3_Frame_Shift_Ins_p.E163fs	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	442					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTCCTGTCTTTCCCCCCGAATG	0.540													7	375	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38531526	38531526	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:38531526delT	ENST00000554687.1	-	0	200				CTD-2058B24.2_ENST00000555342.1_RNA																							tcacattatcttttttttttc	0.403													2	4	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38635905	38635905	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:38635905delA	ENST00000554687.1	-	0	200																											ttaaatgcctaaaatggtgct	0.348													2	4	---	---	---	---					
RP11-398E10.1	0	broad.mit.edu	37	14	45249915	45249915	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:45249915delT	ENST00000556405.1	-	0	275																											atccctgtcatttttagggtg	0.378													2	4	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46951180	46951181	+	RNA	INS	-	-	A	rs76051980	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:46951180_46951181insA	ENST00000556886.1	+	0	349					NR_102701.1																						AAGGGTAGCATAGGAGGGATTT	0.332													3	3	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57416658	57416661	+	RNA	DEL	CACT	CACT	-	rs71104530		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:57416658_57416661delCACT	ENST00000554725.1	+	0	199																											tgcacacacacactcactcacttc	0.431													4	4	---	---	---	---					
RP11-72M17.1	0	broad.mit.edu	37	14	66798776	66798777	+	RNA	DEL	AG	AG	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:66798776_66798777delAG	ENST00000556874.1	-	0	643																											gtgtgtgtgtAGAGAGAGAGAG	0.421													2	4	---	---	---	---					
RP11-718G2.5	0	broad.mit.edu	37	14	70751846	70751849	+	RNA	DEL	ACTC	ACTC	-	rs72296486		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:70751846_70751849delACTC	ENST00000553791.1	+	0	65																											tctcctgagaactcactcactatc	0.515													4	8	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82316317	82316318	+	RNA	DEL	GA	GA	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:82316317_82316318delGA	ENST00000554814.1	+	0	315																											gagaggaagtgagagagagagg	0.455													2	4	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82405836	82405836	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:82405836delT	ENST00000554814.1	+	0	315																											caaagtgccattttttttttt	0.373													2	4	---	---	---	---					
RP11-1152H15.1	0	broad.mit.edu	37	14	88232403	88232403	+	RNA	DEL	T	T	-	rs78535779		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr14:88232403delT	ENST00000554305.1	-	0	230																											TCTCTGTCACTTTTTTTTTTT	0.393													4	2	---	---	---	---					
LINC00933	100506874	broad.mit.edu	37	15	85115423	85115423	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr15:85115423delT	ENST00000557887.1	+	0	1					NR_038273.1|NR_038274.1																						CATAATGCTCttttttttttt	0.393													3	3	---	---	---	---					
RP11-876N24.2	0	broad.mit.edu	37	16	10959649	10959650	+	RNA	INS	-	-	A	rs147438620		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:10959649_10959650insA	ENST00000572017.1	-	0	438																											aagaccctgtcaaaaaaaaaaa	0.470													2	4	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58947241	58947242	+	RNA	INS	-	-	C	rs71157940		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:58947241_58947242insC	ENST00000500117.1	+	0	679																											tgcaacctccaccccccaggct	0.495													4	2	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	59034430	59034431	+	RNA	INS	-	-	CACACACA	rs72021717	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:59034430_59034431insCACACACA	ENST00000500117.1	+	0	679																											tctctctctctcacacacacac	0.441													3	4	---	---	---	---					
RP11-368L12.1	0	broad.mit.edu	37	16	63573938	63573939	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:63573938_63573939insA	ENST00000564290.1	-	0	354																											AACAAGTAAGCAAAAACAACAA	0.302													2	4	---	---	---	---					
CTD-2336H13.2	0	broad.mit.edu	37	16	76838905	76838906	+	RNA	DEL	GG	GG	-	rs77900730		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr16:76838905_76838906delGG	ENST00000567777.1	+	0	138																											gggtgacagaggggggagaccc	0.579													6	0	---	---	---	---					
RP11-429O1.1	0	broad.mit.edu	37	17	50499934	50499934	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:50499934delA	ENST00000572848.1	+	0	76																											ggggagggggaagggatagaa	0.468													2	4	---	---	---	---					
RP11-515E23.1	0	broad.mit.edu	37	17	53547343	53547343	+	RNA	DEL	A	A	-	rs55821488		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:53547343delA	ENST00000577089.1	-	0	230																											aactccatctaaaaaaaaaac	0.498													3	3	---	---	---	---					
RP11-101O21.1	0	broad.mit.edu	37	17	72074150	72074151	+	RNA	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr17:72074150_72074151insC	ENST00000584003.1	-	0	515																											gggggcagtttcccccctaccg	0.460													2	4	---	---	---	---					
RP11-178F10.2	0	broad.mit.edu	37	18	22069400	22069401	+	RNA	INS	-	-	TG	rs72402664	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:22069400_22069401insTG	ENST00000583122.1	+	0	28																											atttgtgtgtatgtgtgtgtgt	0.545													3	4	---	---	---	---					
RP11-746B8.1	0	broad.mit.edu	37	18	30416667	30416667	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:30416667delT	ENST00000582239.1	+	0	393				RP11-746B8.1_ENST00000583612.1_RNA|RP11-746B8.1_ENST00000580366.1_RNA|RP11-746B8.1_ENST00000578782.1_RNA																							CTGTCATAAATTTCAACCCAG	0.428													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	36848205	36848206	+	RNA	DEL	CA	CA	-	rs34989487		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:36848205_36848206delCA	ENST00000591629.1	-	0	440					NR_024391.1																						TACACACACGCACACACACACA	0.292													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37132645	37132646	+	RNA	INS	-	-	A			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:37132645_37132646insA	ENST00000591629.1	-	0	282					NR_024391.1																						CTGGAAGAATGAAAAACTGCCA	0.396													2	4	---	---	---	---					
KC6	641516	broad.mit.edu	37	18	39094397	39094398	+	RNA	DEL	AC	AC	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:39094397_39094398delAC	ENST00000592302.1	-	0	350					NR_002838.1																						TATGTAGcatacacacacacac	0.371													3	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	39791692	39791692	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:39791692delT	ENST00000593234.1	+	0	95					NR_046456.1																						CATTGCACTCTTTGTAACCAG	0.358													2	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	40036195	40036195	+	RNA	DEL	T	T	-	rs72057633		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:40036195delT	ENST00000593234.1	+	0	963					NR_046456.1																						ctttgcacagttttttttttt	0.338													5	4	---	---	---	---					
RP11-325K19.1	0	broad.mit.edu	37	18	58389306	58389307	+	RNA	DEL	TG	TG	-	rs141035912		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:58389306_58389307delTG	ENST00000591869.1	-	0	228																											gagtatacattgtgtgtgtgtg	0.347													8	7	---	---	---	---					
RP11-879F14.1	0	broad.mit.edu	37	18	59313212	59313212	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:59313212delG	ENST00000590968.1	-	0	317																											caagctcccaggggatgccaa	0.418													2	4	---	---	---	---					
LOC284294	284294	broad.mit.edu	37	18	61986251	61986251	+	RNA	DEL	C	C	-	rs74171717	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:61986251delC	ENST00000589376.1	+	0	580					NR_033881.1																						ctccttccttcctttctttct	0.423													2	4	---	---	---	---					
LINC01541	100505776	broad.mit.edu	37	18	69226800	69226801	+	RNA	DEL	TT	TT	-	rs59702891		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr18:69226800_69226801delTT	ENST00000568095.1	-	0	150					NR_038325.1																						ttcctctccctttctctctctc	0.460													3	3	---	---	---	---					
CTD-2562J15.6	0	broad.mit.edu	37	19	16405930	16405931	+	RNA	INS	-	-	GGA	rs5827330	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:16405930_16405931insGGA	ENST00000588799.1	-	0	208																											gagggggagggggaggaggagg	0.530													5	2	---	---	---	---					
CTD-2050I18.1	0	broad.mit.edu	37	19	32041273	32041274	+	RNA	INS	-	-	G			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:32041273_32041274insG	ENST00000593063.1	+	0	345																											ctgcagggcttggggggcctca	0.455													2	4	---	---	---	---					
RYR1	6261	broad.mit.edu	37	19	39008211	39008212	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:39008211_39008212insC	ENST00000355481.4	+	66	10029_10030	c.9898_9899insC	c.(9898-9900)cccfs	p.P3300fs	RYR1_ENST00000360985.3_Frame_Shift_Ins_p.P3300fs|RYR1_ENST00000359596.3_Frame_Shift_Ins_p.P3300fs	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3300					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCCGCCGGCGCCCCCCCACCC	0.658													8	90	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243051	50243052	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:50243051_50243052insC	ENST00000246801.3	-	11	1842_1843	c.1760_1761insG	c.(1759-1761)gtcfs	p.V587fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.V387fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	587							protein binding	p.G587G(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CAGGGGCTGAGCCCCCCTGTTT	0.554													7	382	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57209250	57209251	+	RNA	INS	-	-	TTCT	rs143112446	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:57209250_57209251insTTCT	ENST00000597822.1	+	0	60																											tcctctctcccttggctgtcca	0.450													3	4	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57221367	57221368	+	RNA	DEL	GT	GT	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr19:57221367_57221368delGT	ENST00000594400.1	+	0	266				AC006115.3_ENST00000600093.1_RNA|AC006115.3_ENST00000597822.1_RNA																							TTGTGTGCGAGTGTGTGTGTGT	0.465													4	9	---	---	---	---					
SNAP25-AS1	100131208	broad.mit.edu	37	20	10161399	10161400	+	RNA	INS	-	-	T			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr20:10161399_10161400insT	ENST00000603542.1	-	0	638				RP11-416N4.1_ENST00000458004.1_lincRNA|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25-AS1_ENST00000605592.1_RNA|RP11-416N4.4_ENST00000424931.1_lincRNA|SNAP25-AS1_ENST00000426491.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000451151.1_RNA	NR_040710.1																						CATTTCTTTTCTTTTTTGACAT	0.391													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11039939	11039941	+	RNA	DEL	GTT	GTT	-	rs146620410		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:11039939_11039941delGTT	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGATATAATCGTTGTTCTTCATC	0.320													5	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11043637	11043638	+	RNA	INS	-	-	A	rs59194524		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:11043637_11043638insA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTGAAAAAAGAAAAAAACAAG	0.342													4	9	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11093134	11093135	+	RNA	INS	-	-	C	rs141935972		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:11093134_11093135insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTCTCCCCTACCCCCCACAAC	0.401													7	7	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11094127	11094128	+	RNA	INS	-	-	T	rs142937341		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:11094127_11094128insT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGCACAGTGTGTTTTTTTCCAC	0.292													6	9	---	---	---	---					
AP000235.3	0	broad.mit.edu	37	21	26433774	26433774	+	RNA	DEL	T	T	-	rs34334984		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:26433774delT	ENST00000424017.1	+	0	50																											ccTGAGGGGGttttttttttt	0.423													2	4	---	---	---	---					
AP000318.2	0	broad.mit.edu	37	21	35689835	35689835	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:35689835delG	ENST00000427022.1	+	0	506																											AAAATTTTATGGTAACTTCTA	0.269													2	4	---	---	---	---					
LINC00114	400866	broad.mit.edu	37	21	40111843	40111843	+	RNA	DEL	G	G	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr21:40111843delG	ENST00000411989.1	-	0	1481																											GGATGGTGATGGGGGGAGAAG	0.413													2	4	---	---	---	---					
RP1-302D9.2	0	broad.mit.edu	37	22	33509859	33509859	+	RNA	DEL	C	C	-	rs137305		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr22:33509859delC	ENST00000452505.1	+	0	463																											tagggattttctttttttttt	0.473													2	4	---	---	---	---					
LL22NC03-86D4.1	0	broad.mit.edu	37	22	34443336	34443337	+	RNA	INS	-	-	T	rs140722215	by1000genomes	TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chr22:34443336_34443337insT	ENST00000412218.1	+	0	55																											TTCATCTTCCATTGCAGTGGAC	0.421													8	1	---	---	---	---					
RP11-1M18.1	0	broad.mit.edu	37	X	6587829	6587832	+	RNA	DEL	GGAT	GGAT	-	rs71998623		TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:6587829_6587832delGGAT	ENST00000438499.1	-	0	252																											aaggatagaaggatggatggatgg	0.402													4	6	---	---	---	---					
RP4-646N3.1	0	broad.mit.edu	37	X	38635276	38635276	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:38635276delC	ENST00000432359.1	+	0	245																											gtttccttttctccacattct	0.343													2	4	---	---	---	---					
NKAPP1	158801	broad.mit.edu	37	X	119278466	119278466	+	RNA	DEL	A	A	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:119278466delA	ENST00000553843.1	+	0	885																											TTGGGAAAAGAAAAAAAAAGC	0.547													2	4	---	---	---	---					
SPANXA2-OT1	619455	broad.mit.edu	37	X	140596007	140596007	+	RNA	DEL	T	T	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:140596007delT	ENST00000421554.1	+	0	406					NR_037183.1																						gtgactctaaTTtgtgtgtgt	0.443													2	4	---	---	---	---					
TMLHE-AS1	100507404	broad.mit.edu	37	X	154696863	154696864	+	RNA	INS	-	-	TG			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrX:154696863_154696864insTG	ENST00000433624.1	+	0	310				TMLHE-AS1_ENST00000541151.1_RNA	NR_039991.1																						TAAGTAATTGAtgtgtgtgtgt	0.376													4	5	---	---	---	---					
RNA5-8SP6	100873336	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-17-Z027-01A-01W-0746-08	TCGA-17-Z027-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880452fe-00ed-4732-bbcf-14b55c235e61	3b74da0c-a646-4170-8034-2411a17966ca	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													4	9	---	---	---	---					
